@article{SchmidtMieuletHubbertenetal.2013,
  author    = {Schmidt, Romy and Mieulet, Delphine and Hubberten, Hans-Michael and Obata, Toshihiro and H{\"o}fgen, Rainer and Fernie, Alisdair R. and Fisahn, Joachim and Segundo, Blanca San and Guiderdoni, Emmanuel and Schippers, Jos H. M. and M{\"u}ller-R{\"o}ber, Bernd},
  title     = {Salt-responsive ERF1 regulates reactive oxygen species-dependent signaling during the initial response to salt stress in rice},
  series = {The plant cell},
  volume    = {25},
  journal   = {The plant cell},
  number    = {6},
  publisher = {American Society of Plant Physiologists},
  address   = {Rockville},
  issn      = {1040-4651},
  doi       = {10.1105/tpc.113.113068},
  pages     = {2115 -- 2131},
  year      = {2013},
  abstract  = {Early detection of salt stress is vital for plant survival and growth. Still, the molecular processes controlling early salt stress perception and signaling are not fully understood. Here, we identified SALT-RESPONSIVE ERF1 (SERF1), a rice (Oryza sativa) transcription factor (TF) gene that shows a root-specific induction upon salt and hydrogen peroxide (H2O2) treatment. Loss of SERF1 impairs the salt-inducible expression of genes encoding members of a mitogen-activated protein kinase (MAPK) cascade and salt tolerance-mediating TFs. Furthermore, we show that SERF1-dependent genes are H2O2 responsive and demonstrate that SERF1 binds to the promoters of MAPK KINASE KINASE6 (MAP3K6), MAPK5, DEHYDRATION-RESPONSIVE ELEMENT BINDING2A (DREB2A), and ZINC FINGER PROTEIN179 (ZFP179) in vitro and in vivo. SERF1 also directly induces its own gene expression. In addition, SERF1 is a phosphorylation target of MAPK5, resulting in enhanced transcriptional activity of SERF1 toward its direct target genes. In agreement, plants deficient for SERF1 are more sensitive to salt stress compared with the wild type, while constitutive overexpression of SERF1 improves salinity tolerance. We propose that SERF1 amplifies the reactive oxygen species-activated MAPK cascade signal during the initial phase of salt stress and translates the salt-induced signal into an appropriate expressional response resulting in salt tolerance.},
  language  = {en}
}
@article{SchmidtSchippersMieuletetal.2013,
  author    = {Schmidt, Romy and Schippers, Jos H. M. and Mieulet, Delphine and Obata, Toshihiro and Fernie, Alisdair R. and Guiderdoni, Emmanuel and M{\"u}ller-R{\"o}ber, Bernd},
  title     = {Multipass, a rice R2R3-type MYB transcription factor, regulates adaptive growth by integrating multiple hormonal pathways},
  series = {The plant journal},
  volume    = {76},
  journal   = {The plant journal},
  number    = {2},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {0960-7412},
  doi       = {10.1111/tpj.12286},
  pages     = {258 -- 273},
  year      = {2013},
  abstract  = {Growth regulation is an important aspect of plant adaptation during environmental perturbations. Here, the role of MULTIPASS (OsMPS), an R2R3-type MYB transcription factor of rice, was explored. OsMPS is induced by salt stress and expressed in vegetative and reproductive tissues. Over-expression of OsMPS reduces growth under non-stress conditions, while knockdown plants display increased biomass. OsMPS expression is induced by abscisic acid and cytokinin, but is repressed by auxin, gibberellin and brassinolide. Growth retardation caused by OsMPS over-expression is partially restored by auxin application. Expression profiling revealed that OsMPS negatively regulates the expression of EXPANSIN (EXP) and cell-wall biosynthesis as well as phytohormone signaling genes. Furthermore, the expression of OsMPS-dependent genes is regulated by auxin, cytokinin and abscisic acid. Moreover, we show that OsMPS is a direct upstream regulator of OsEXPA4, OsEXPA8, OsEXPB2, OsEXPB3, OsEXPB6 and the endoglucanase genes OsGLU5 and OsGLU14. The multiple responses of OsMPS and its target genes to various hormones suggest an integrative function of OsMPS in the cross-talk between phytohormones and the environment to regulate adaptive growth.},
  language  = {en}
}
@article{RothwellMurphyAleksandrovaetal.2020,
  author    = {Rothwell, Joseph A. and Murphy, Neil and Aleksandrova, Krasimira and Schulze, Matthias Bernd and Bešević, Jelena and Kliemann, Nathalie and Jenab, Mazda and Ferrari, Pietro and Achaintre, David and Gicquiau, Audrey and Vozar, B{\´e}atrice and Scalbert, Augustin and Huybrechts, Inge and Freisling, Heinz and Prehn, Cornelia and Adamski, Jerzy and Cross, Amanda J. and Pala, Valeria Maria and Boutron-Ruault, Marie-Christine and Dahm, Christina C. and Overvad, Kim and Gram, Inger Torhild and Sandanger, Torkjel M. and Skeie, Guri and Jakszyn, Paula and Tsilidis, Kostas K. and Hughes, David J. and van Guelpen, Bethany and Bod{\´e}n, Stina and S{\´a}nchez, Maria-Jos{\´e} and Schmidt, Julie A. and Katzke, Verena and K{\"u}hn, Tilman and Colorado-Yohar, Sandra and Tumino, Rosario and Bueno-de-Mesquita, Bas and Vineis, Paolo and Masala, Giovanna and Panico, Salvatore and Eriksen, Anne Kirstine and Tj{\o}nneland, Anne and Aune, Dagfinn and Weiderpass, Elisabete and Severi, Gianluca and Chaj{\`e}s, V{\´e}ronique and Gunter, Marc J.},
  title     = {Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort},
  series = {Clinical gastroenterology and hepatology},
  volume    = {20},
  journal   = {Clinical gastroenterology and hepatology},
  publisher = {Elsevier},
  address   = {New York, NY},
  issn      = {1542-3565},
  doi       = {10.1016/j.cgh.2020.11.045},
  pages     = {E1061 -- E1082},
  year      = {2020},
  abstract  = {BACKGROUND \& AIMS: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. METHODS: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95\% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. RESULTS: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95\% CI, 0.29-0.90; endogenous metabolites: OR, 0.62 per unit change; 95\% CI, 0.50-0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95\% CI, 0.86-1.00) overall. Signature associations were stronger in male compared with female participants. CONCLUSIONS: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.},
  language  = {en}
}
@misc{SchroederGrimmSchulzetal.2017,
  author    = {Schr{\"o}der, Astrid and Grimm, Angela and Schulz, Petra and Heide, Judith and Frank, Ulrike and Wahl, Michael and Lampe, Leonie and Fieder, Nora and Krajenbrink, Trudy and Nickels, Lyndsey and Bykova, Ksenia and Wilzek, Alexa and van den Engl-Hoek, Lenie and Huckabee, Maggie-Lee and Balzer, Julia and Ebert, Susanne and Kaps, Hella and Matteschk, Maria and Tzsch{\"o}ckel, Katharina Andrea and Dressel, Katharina and Kr{\"o}ger, Bernd J. and Diwoky, Laura Cassandra and Breitenstein, Sarah and Bruno, Giulia and Lassotta, Romy and Adani, Flavia and Ferchland, Lisa and Baatz, Charlotte and Netzebandt, Jonka and Heyde, Cornelia J. and Cleland, Joanne and Scobbie, James M. and Roxburgh, Zoe and Schmidt, Jessica},
  title     = {Spektrum Patholinguistik Band 10. Schwerpunktthema: Panorama Patholinguistik: Sprachwissenschaft trifft Sprachtherapie},
  number    = {10},
  editor    = {Adelt, Anne and Yetim, {\"O}zlem and Otto, Constanze and Fritzsche, Tom},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  organization    = {Verband f{\"u}r Patholinguistik e. V. (vpl)},
  isbn      = {978-3-86956-404-3},
  issn      = {1866-9085},
  doi       = {10.25932/publishup-39701},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-397019},
  pages     = {vii, 225 S.},
  year      = {2017},
  abstract  = {Das 10. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Panorama Patholinguistik: Sprachwissenschaft trifft Sprachtherapie« fand am 19.11.2016 in Potsdam statt. Das Herbsttreffen wird seit 2007 j{\"a}hrlich vom Verband f{\"u}r Patholinguistik e.V. (vpl) durchgef{\"u}hrt. Der vorliegende Tagungsband beinhaltet die vier Hauptvortr{\"a}ge zum Schwerpunktthema sowie Beitr{\"a}ge zu den Kurzvortr{\"a}gen »Patholinguistik im Fokus« und der Posterpr{\"a}sentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis.},
  language  = {de}
}