@article{IkramFornageSmithetal.2012, author = {Ikram, M. Arfan and Fornage, Myriam and Smith, Albert V. and Seshadri, Sudha and Schmidt, Reinhold and Debette, Stephanie and Vrooman, Henri A. and Sigurdsson, Sigurdur and Ropele, Stefan and Taal, H. Rob and Mook-Kanamori, Dennis O. and Coker, Laura H. and Longstreth, W. T. and Niessen, Wiro J. and DeStefano, Anita L. and Beiser, Alexa and Zijdenbos, Alex P. and Struchalin, Maksim and Jack, Clifford R. and Rivadeneira, Fernando and Uitterlinden, Andre G. and Knopman, David S. and Hartikainen, Anna-Liisa and Pennell, Craig E. and Thiering, Elisabeth and Steegers, Eric A. P. and Hakonarson, Hakon and Heinrich, Joachim and Palmer, Lyle J. and Jarvelin, Marjo-Riitta and McCarthy, Mark I. and Grant, Struan F. A. and St Pourcain, Beate and Timpson, Nicholas J. and Smith, George Davey and Sovio, Ulla and Nalls, Mike A. and Au, Rhoda and Hofman, Albert and Gudnason, Haukur and van der Lugt, Aad and Harris, Tamara B. and Meeks, William M. and Vernooij, Meike W. and van Buchem, Mark A. and Catellier, Diane and Jaddoe, Vincent W. V. and Gudnason, Vilmundur and Windham, B. Gwen and Wolf, Philip A. and van Duijn, Cornelia M. and Mosley, Thomas H. and Schmidt, Helena and Launer, Lenore J. and Breteler, Monique M. B. and DeCarli, Charles and Adair, Linda S. and Ang, Wei and Atalay, Mustafa and vanBeijsterveldt, Toos and Bergen, Nienke and Benke, Kelly and Berry, Diane J. and Coin, Lachlan and Davis, Oliver S. P. and Elliott, Paul and Flexeder, Claudia and Frayling, Tim and Gaillard, Romy and Groen-Blokhuis, Maria and Goh, Liang-Kee and Haworth, Claire M. A. and Hadley, Dexter and Hebebrand, Johannes and Hinney, Anke and Hirschhorn, Joel N. and Holloway, John W. and Holst, Claus and Hottenga, Jouke Jan and Horikoshi, Momoko and Huikari, Ville and Hypponen, Elina and Kilpelainen, Tuomas O. and Kirin, Mirna and Kowgier, Matthew and Lakka, Hanna-Maaria and Lange, Leslie A. and Lawlor, Debbie A. and Lehtimaki, Terho and Lewin, Alex and Lindgren, Cecilia and Lindi, Virpi and Maggi, Reedik and Marsh, Julie and Middeldorp, Christel and Millwood, Iona and Murray, Jeffrey C. and Nivard, Michel and Nohr, Ellen Aagaard and Ntalla, Ioanna and Oken, Emily and Panoutsopoulou, Kalliope and Pararajasingham, Jennifer and Rodriguez, Alina and Salem, Rany M. and Sebert, Sylvain and Siitonen, Niina and Strachan, David P. and Teo, Yik-Ying and Valcarcel, Beatriz and Willemsen, Gonneke and Zeggini, Eleftheria and Boomsma, Dorret I. and Cooper, Cyrus and Gillman, Matthew and Hocher, Berthold and Lakka, Timo A. and Mohlke, Karen L. and Dedoussis, George V. and Ong, Ken K. and Pearson, Ewan R. and Price, Thomas S. and Power, Chris and Raitakari, Olli T. and Saw, Seang-Mei and Scherag, Andre and Simell, Olli and Sorensen, Thorkild I. A. and Wilson, James F.}, title = {Common variants at 6q22 and 17q21 are associated with intracranial volume}, series = {Nature genetics}, volume = {44}, journal = {Nature genetics}, number = {5}, publisher = {Nature Publ. Group}, address = {New York}, organization = {Early Growth Genetics EGG Consorti, Cohorts Heart Aging Res Genomic Ep}, issn = {1061-4036}, doi = {10.1038/ng.2245}, pages = {539 -- +}, year = {2012}, abstract = {During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.}, language = {en} } @article{WuttkeLiLietal.2019, author = {Wuttke, Matthias and Li, Yong and Li, Man and Sieber, Karsten B. and Feitosa, Mary F. and Gorski, Mathias and Tin, Adrienne and Wang, Lihua and Chu, Audrey Y. and Hoppmann, Anselm and Kirsten, Holger and Giri, Ayush and Chai, Jin-Fang and Sveinbjornsson, Gardar and Tayo, Bamidele O. and Nutile, Teresa and Fuchsberger, Christian and Marten, Jonathan and Cocca, Massimiliano and Ghasemi, Sahar and Xu, Yizhe and Horn, Katrin and Noce, Damia and Van der Most, Peter J. and Sedaghat, Sanaz and Yu, Zhi and Akiyama, Masato and Afaq, Saima and Ahluwalia, Tarunveer Singh and Almgren, Peter and Amin, Najaf and Arnlov, Johan and Bakker, Stephan J. L. and Bansal, Nisha and Baptista, Daniela and Bergmann, Sven and Biggs, Mary L. and Biino, Ginevra and Boehnke, Michael and Boerwinkle, Eric and Boissel, Mathilde and B{\"o}ttinger, Erwin and Boutin, Thibaud S. and Brenner, Hermann and Brumat, Marco and Burkhardt, Ralph and Butterworth, Adam S. and Campana, Eric and Campbell, Archie and Campbell, Harry and Canouil, Mickael and Carroll, Robert J. and Catamo, Eulalia and Chambers, John C. and Chee, Miao-Ling and Chee, Miao-Li and Chen, Xu and Cheng, Ching-Yu and Cheng, Yurong and Christensen, Kaare and Cifkova, Renata and Ciullo, Marina and Concas, Maria Pina and Cook, James P. and Coresh, Josef and Corre, Tanguy and Sala, Cinzia Felicita and Cusi, Daniele and Danesh, John and Daw, E. Warwick and De Borst, Martin H. and De Grandi, Alessandro and De Mutsert, Renee and De Vries, Aiko P. J. and Degenhardt, Frauke and Delgado, Graciela and Demirkan, Ayse and Di Angelantonio, Emanuele and Dittrich, Katalin and Divers, Jasmin and Dorajoo, Rajkumar and Eckardt, Kai-Uwe and Ehret, Georg and Elliott, Paul and Endlich, Karlhans and Evans, Michele K. and Felix, Janine F. and Foo, Valencia Hui Xian and Franco, Oscar H. and Franke, Andre and Freedman, Barry I. and Freitag-Wolf, Sandra and Friedlander, Yechiel and Froguel, Philippe and Gansevoort, Ron T. and Gao, He and Gasparini, Paolo and Gaziano, J. Michael and Giedraitis, Vilmantas and Gieger, Christian and Girotto, Giorgia and Giulianini, Franco and Gogele, Martin and Gordon, Scott D. and Gudbjartsson, Daniel F. and Gudnason, Vilmundur and Haller, Toomas and Hamet, Pavel and Harris, Tamara B. and Hartman, Catharina A. and Hayward, Caroline and Hellwege, Jacklyn N. and Heng, Chew-Kiat and Hicks, Andrew A. and Hofer, Edith and Huang, Wei and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Indridason, Olafur S. and Ingelsson, Erik and Ising, Marcus and Jaddoe, Vincent W. V. and Jakobsdottir, Johanna and Jonas, Jost B. and Joshi, Peter K. and Josyula, Navya Shilpa and Jung, Bettina and Kahonen, Mika and Kamatani, Yoichiro and Kammerer, Candace M. and Kanai, Masahiro and Kastarinen, Mika and Kerr, Shona M. and Khor, Chiea-Chuen and Kiess, Wieland and Kleber, Marcus E. and Koenig, Wolfgang and Kooner, Jaspal S. and Korner, Antje and Kovacs, Peter and Kraja, Aldi T. and Krajcoviechova, Alena and Kramer, Holly and Kramer, Bernhard K. and Kronenberg, Florian and Kubo, Michiaki and Kuhnel, Brigitte and Kuokkanen, Mikko and Kuusisto, Johanna and La Bianca, Martina and Laakso, Markku and Lange, Leslie A. and Langefeld, Carl D. and Lee, Jeannette Jen-Mai and Lehne, Benjamin and Lehtimaki, Terho and Lieb, Wolfgang and Lim, Su-Chi and Lind, Lars and Lindgren, Cecilia M. and Liu, Jun and Liu, Jianjun and Loeffler, Markus and Loos, Ruth J. F. and Lucae, Susanne and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Magi, Reedik and Magnusson, Patrik K. E. and Mahajan, Anubha and Martin, Nicholas G. and Martins, Jade and Marz, Winfried and Mascalzoni, Deborah and Matsuda, Koichi and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Metspalu, Andres and Mikaelsdottir, Evgenia K. and Milaneschi, Yuri and Miliku, Kozeta and Mishra, Pashupati P. and Program, V. A. Million Veteran and Mohlke, Karen L. and Mononen, Nina and Montgomery, Grant W. and Mook-Kanamori, Dennis O. and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nalls, Mike A. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and Noordam, Raymond and Olafsson, Isleifur and Oldehinkel, Albertine J. and Orho-Melander, Marju and Ouwehand, Willem H. and Padmanabhan, Sandosh and Palmer, Nicholette D. and Palsson, Runolfur and Penninx, Brenda W. J. H. and Perls, Thomas and Perola, Markus and Pirastu, Mario and Pirastu, Nicola and Pistis, Giorgio and Podgornaia, Anna I. and Polasek, Ozren and Ponte, Belen and Porteous, David J. and Poulain, Tanja and Pramstaller, Peter P. and Preuss, Michael H. and Prins, Bram P. and Province, Michael A. and Rabelink, Ton J. and Raffield, Laura M. and Raitakari, Olli T. and Reilly, Dermot F. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Ridker, Paul M. and Rivadeneira, Fernando and Rizzi, Federica and Roberts, David J. and Robino, Antonietta and Rossing, Peter and Rudan, Igor and Rueedi, Rico and Ruggiero, Daniela and Ryan, Kathleen A. and Saba, Yasaman and Sabanayagam, Charumathi and Salomaa, Veikko and Salvi, Erika and Saum, Kai-Uwe and Schmidt, Helena and Schmidt, Reinhold and Ben Schottker, and Schulz, Christina-Alexandra and Schupf, Nicole and Shaffer, Christian M. and Shi, Yuan and Smith, Albert V. and Smith, Blair H. and Soranzo, Nicole and Spracklen, Cassandra N. and Strauch, Konstantin and Stringham, Heather M. and Stumvoll, Michael and Svensson, Per O. and Szymczak, Silke and Tai, E-Shyong and Tajuddin, Salman M. and Tan, Nicholas Y. Q. and Taylor, Kent D. and Teren, Andrej and Tham, Yih-Chung and Thiery, Joachim and Thio, Chris H. L. and Thomsen, Hauke and Thorleifsson, Gudmar and Toniolo, Daniela and Tonjes, Anke and Tremblay, Johanne and Tzoulaki, Ioanna and Uitterlinden, Andre G. and Vaccargiu, Simona and Van Dam, Rob M. and Van der Harst, Pim and Van Duijn, Cornelia M. and Edward, Digna R. Velez and Verweij, Niek and Vogelezang, Suzanne and Volker, Uwe and Vollenweider, Peter and Waeber, Gerard and Waldenberger, Melanie and Wallentin, Lars and Wang, Ya Xing and Wang, Chaolong and Waterworth, Dawn M. and Bin Wei, Wen and White, Harvey and Whitfield, John B. and Wild, Sarah H. and Wilson, James F. and Wojczynski, Mary K. and Wong, Charlene and Wong, Tien-Yin and Xu, Liang and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Weihua and Zonderman, Alan B. and Rotter, Jerome I. and Bochud, Murielle and Psaty, Bruce M. and Vitart, Veronique and Wilson, James G. and Dehghan, Abbas and Parsa, Afshin and Chasman, Daniel I. and Ho, Kevin and Morris, Andrew P. and Devuyst, Olivier and Akilesh, Shreeram and Pendergrass, Sarah A. and Sim, Xueling and Boger, Carsten A. and Okada, Yukinori and Edwards, Todd L. and Snieder, Harold and Stefansson, Kari and Hung, Adriana M. and Heid, Iris M. and Scholz, Markus and Teumer, Alexander and Kottgen, Anna and Pattaro, Cristian}, title = {A catalog of genetic loci associated with kidney function from analyses of a million individuals}, series = {Nature genetics}, volume = {51}, journal = {Nature genetics}, number = {6}, publisher = {Nature Publ. Group}, address = {New York}, organization = {Lifelines COHort Study}, issn = {1061-4036}, doi = {10.1038/s41588-019-0407-x}, pages = {957 -- +}, year = {2019}, abstract = {Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.}, language = {en} } @article{TaalStPourcainThieringetal.2012, author = {Taal, H. Rob and St Pourcain, Beate and Thiering, Elisabeth and Das, Shikta and Mook-Kanamori, Dennis O. and Warrington, Nicole M. and Kaakinen, Marika and Kreiner-Moller, Eskil and Bradfield, Jonathan P. and Freathy, Rachel M. and Geller, Frank and Guxens, Monica and Cousminer, Diana L. and Kerkhof, Marjan and Timpson, Nicholas J. and Ikram, M. Arfan and Beilin, Lawrence J. and Bonnelykke, Klaus and Buxton, Jessica L. and Charoen, Pimphen and Chawes, Bo Lund Krogsgaard and Eriksson, Johan and Evans, David M. and Hofman, Albert and Kemp, John P. and Kim, Cecilia E. and Klopp, Norman and Lahti, Jari and Lye, Stephen J. and McMahon, George and Mentch, Frank D. and Mueller-Nurasyid, Martina and O'Reilly, Paul F. and Prokopenko, Inga and Rivadeneira, Fernando and Steegers, Eric A. P. and Sunyer, Jordi and Tiesler, Carla and Yaghootkar, Hanieh and Breteler, Monique M. B. and Debette, Stephanie and Fornage, Myriam and Gudnason, Vilmundur and Launer, Lenore J. and van der Lugt, Aad and Mosley, Thomas H. and Seshadri, Sudha and Smith, Albert V. and Vernooij, Meike W. and Blakemore, Alexandra I. F. and Chiavacci, Rosetta M. and Feenstra, Bjarke and Fernandez-Banet, Julio and Grant, Struan F. A. and Hartikainen, Anna-Liisa and van der Heijden, Albert J. and Iniguez, Carmen and Lathrop, Mark and McArdle, Wendy L. and Molgaard, Anne and Newnham, John P. and Palmer, Lyle J. and Palotie, Aarno and Pouta, Annneli and Ring, Susan M. and Sovio, Ulla and Standl, Marie and Uitterlinden, Andre G. and Wichmann, H-Erich and Vissing, Nadja Hawwa and DeCarli, Charles and van Duijn, Cornelia M. and McCarthy, Mark I. and Koppelman, Gerard H. and Estivill, Xavier and Hattersley, Andrew T. and Melbye, Mads and Bisgaard, Hans and Pennell, Craig E. and Widen, Elisabeth and Hakonarson, Hakon and Smith, George Davey and Heinrich, Joachim and Jarvelin, Marjo-Riitta and Jaddoe, Vincent W. V. and Adair, Linda S. and Ang, Wei and Atalay, Mustafa and van Beijsterveldt, Toos and Bergen, Nienke and Benke, Kelly and Berry, Diane J. and Bradfield, Jonathan P. and Charoen, Pimphen and Coin, Lachlan and Cousminer, Diana L. and Das, Shikta and Davis, Oliver S. P. and Elliott, Paul and Evans, David M. and Feenstra, Bjarke and Flexeder, Claudia and Frayling, Tim and Freathy, Rachel M. and Gaillard, Romy and Geller, Frank and Groen-Blokhuis, Maria and Goh, Liang-Kee and Guxens, Monica and Haworth, Claire M. A. and Hadley, Dexter and Hebebrand, Johannes and Hinney, Anke and Hirschhorn, Joel N. and Holloway, John W. and Holst, Claus and Hottenga, Jouke Jan and Horikoshi, Momoko and Huikari, Ville and Hypponen, Elina and Iniguez, Carmen and Kaakinen, Marika and Kilpelainen, Tuomas O. and Kirin, Mirna and Kowgier, Matthew and Lakka, Hanna-Maaria and Lange, Leslie A. and Lawlor, Debbie A. and Lehtimaki, Terho and Lewin, Alex and Lindgren, Cecilia and Lindi, Virpi and Maggi, Reedik and Marsh, Julie and Middeldorp, Christel and Millwood, Iona and Mook-Kanamori, Dennis O. and Murray, Jeffrey C. and Nivard, Michel and Nohr, Ellen Aagaard and Ntalla, Ioanna and Oken, Emily and O'Reilly, Paul F. and Palmer, Lyle J. and Panoutsopoulou, Kalliope and Pararajasingham, Jennifer and Prokopenko, Inga and Rodriguez, Alina and Salem, Rany M. and Sebert, Sylvain and Siitonen, Niina and Sovio, Ulla and St Pourcain, Beate and Strachan, David P. and Sunyer, Jordi and Taal, H. Rob and Teo, Yik-Ying and Thiering, Elisabeth and Tiesler, Carla and Uitterlinden, Andre G. and Valcarcel, Beatriz and Warrington, Nicole M. and White, Scott and Willemsen, Gonneke and Yaghootkar, Hanieh and Zeggini, Eleftheria and Boomsma, Dorret I. and Cooper, Cyrus and Estivill, Xavier and Gillman, Matthew and Grant, Struan F. A. and Hakonarson, Hakon and Hattersley, Andrew T. and Heinrich, Joachim and Hocher, Berthold and Jaddoe, Vincent W. V. and Jarvelin, Marjo-Riitta and Lakka, Timo A. and McCarthy, Mark I. and Melbye, Mads and Mohlke, Karen L. and Dedoussis, George V. and Ong, Ken K. and Pearson, Ewan R. and Pennell, Craig E. and Price, Thomas S. and Power, Chris and Raitakari, Olli T. and Saw, Seang-Mei and Scherag, Andre and Simell, Olli and Sorensen, Thorkild I. A. and Timpson, Nicholas J. and Widen, Elisabeth and Wilson, James F. and Ang, Wei and van Beijsterveldt, Toos and Bergen, Nienke and Benke, Kelly and Berry, Diane J. and Bradfield, Jonathan P. and Charoen, Pimphen and Coin, Lachlan and Cousminer, Diana L. and Das, Shikta and Elliott, Paul and Evans, David M. and Frayling, Tim and Freathy, Rachel M. and Gaillard, Romy and Groen-Blokhuis, Maria and Guxens, Monica and Hadley, Dexter and Hottenga, Jouke Jan and Huikari, Ville and Hypponen, Elina and Kaakinen, Marika and Kowgier, Matthew and Lawlor, Debbie A. and Lewin, Alex and Lindgren, Cecilia and Marsh, Julie and Middeldorp, Christel and Millwood, Iona and Mook-Kanamori, Dennis O. and Nivard, Michel and O'Reilly, Paul F. and Palmer, Lyle J. and Prokopenko, Inga and Rodriguez, Alina and Sebert, Sylvain and Sovio, Ulla and St Pourcain, Beate and Standl, Marie and Strachan, David P. and Sunyer, Jordi and Taal, H. Rob and Thiering, Elisabeth and Tiesler, Carla and Uitterlinden, Andre G. and Valcarcel, Beatriz and Warrington, Nicole M. and White, Scott and Willemsen, Gonneke and Yaghootkar, Hanieh and Boomsma, Dorret I. and Estivill, Xavier and Grant, Struan F. A. and Hakonarson, Hakon and Hattersley, Andrew T. and Heinrich, Joachim and Jaddoe, Vincent W. V. and Jarvelin, Marjo-Riitta and McCarthy, Mark I. and Pennell, Craig E. and Power, Chris and Timpson, Nicholas J. and Widen, Elisabeth and Ikram, M. Arfan and Fornage, Myriam and Smith, Albert V. and Seshadri, Sudha and Schmidt, Reinhold and Debette, Stephanie and Vrooman, Henri A. and Sigurdsson, Sigurdur and Ropele, Stefan and Coker, Laura H. and Longstreth, W. T. and Niessen, Wiro J. and DeStefano, Anita L. and Beiser, Alexa and Zijdenbos, Alex P. and Struchalin, Maksim and Jack, Clifford R. and Nalls, Mike A. and Au, Rhoda and Hofman, Albert and Gudnason, Haukur and van der Lugt, Aad and Harris, Tamara B. and Meeks, William M. and Vernooij, Meike W. and van Buchem, Mark A. and Catellier, Diane and Gudnason, Vilmundur and Windham, B. Gwen and Wolf, Philip A. and van Duijn, Cornelia M. and Mosley, Thomas H. and Schmidt, Helena and Launer, Lenore J. and Breteler, Monique M. B. and DeCarli, Charles}, title = {Common variants at 12q15 and 12q24 are associated with infant head circumference}, series = {Nature genetics}, volume = {44}, journal = {Nature genetics}, number = {5}, publisher = {Nature Publ. Group}, address = {New York}, organization = {Cohorts Heart Aging Res Genetic Ep, Early Genetics Lifecourse Epidemio, Early Growth Genetics EGG Consorti}, issn = {1061-4036}, doi = {10.1038/ng.2238}, pages = {532 -- +}, year = {2012}, abstract = {To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height(1), their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume(2), Parkinson's disease and other neurodegenerative diseases(3-5), indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.}, language = {en} } @unpublished{AcharyaActisAghajanietal.2013, author = {Acharya, B. S. and Actis, M. and Aghajani, T. and Agnetta, G. and Aguilar, J. and Aharonian, Felix A. and Ajello, M. and Akhperjanian, A. G. and Alcubierre, M. and Aleksic, J. and Alfaro, R. and Aliu, E. and Allafort, A. J. and Allan, D. and Allekotte, I. and Amato, E. and Anderson, J. and Ang{\"u}ner, Ekrem Oǧuzhan and Antonelli, L. A. and Antoranz, P. and Aravantinos, A. and Arlen, T. and Armstrong, T. and Arnaldi, H. and Arrabito, L. and Asano, K. and Ashton, T. and Asorey, H. G. and Awane, Y. and Baba, H. and Babic, A. and Baby, N. and Baehr, J. and Bais, A. and Baixeras, C. and Bajtlik, S. and Balbo, M. and Balis, D. and Balkowski, C. and Bamba, A. and Bandiera, R. and Barber, A. and Barbier, C. and Barcelo, M. and Barnacka, Anna and Barnstedt, J{\"u}rgen and Barres de Almeida, U. and Barrio, J. A. and Basili, A. and Basso, S. and Bastieri, D. and Bauer, C. and Baushev, Anton N. and Becerra Gonzalez, J. and Becherini, Yvonne and Bechtol, K. C. and Tjus, J. Becker and Beckmann, Volker and Bednarek, W. and Behera, B. and Belluso, M. and Benbow, W. and Berdugo, J. and Berger, K. and Bernard, F. and Bernardino, T. and Bernl{\"o}hr, K. and Bhat, N. and Bhattacharyya, S. and Bigongiari, C. and Biland, A. and Billotta, S. and Bird, T. and Birsin, E. and Bissaldi, E. and Biteau, Jonathan and Bitossi, M. and Blake, S. and Blanch Bigas, O. and Blasi, P. and Bobkov, A. A. and Boccone, V. and Boettcher, Markus and Bogacz, L. and Bogart, J. and Bogdan, M. and Boisson, Catherine and Boix Gargallo, J. and Bolmont, J. and Bonanno, G. and Bonardi, A. and Bonev, T. and Bonifacio, P. and Bonnoli, G. and Bordas, Pol and Borgland, A. W. and Borkowski, Janett and Bose, R. and Botner, O. and Bottani, A. and Bouchet, L. and Bourgeat, M. and Boutonnet, C. and Bouvier, A. and Brau-Nogue, S. and Braun, I. and Bretz, T. and Briggs, M. S. and Bringmann, T. and Brook, P. and Brun, Pierre and Brunetti, L. and Buanes, T. and Buckley, J. H. and Buehler, R. and Bugaev, V. and Bulgarelli, A. and Bulik, Tomasz and Busetto, G. and Buson, S. and Byrum, K. and Cailles, M. and Cameron, R. A. and Camprecios, J. and Canestrari, R. and Cantu, S. and Capalbi, M. and Caraveo, P. A. and Carmona, E. and Carosi, A. and Carr, John and Carton, P. 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A. and Lopez, R. de los Reyes and De Lotto, B. and De Luca, A. and de Mello Neto, J. R. 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K. and Yamamoto, H. and Yamamoto, T. and Yamazaki, R. and Yanagita, S. and Yebras, J. M. and Yelos, D. and Yoshida, A. and Yoshida, T. and Yoshikoshi, T. and Zabalza, V. and Zacharias, M. and Zajczyk, A. and Zanin, R. and Zdziarski, A. and Zech, Alraune and Zhao, A. and Zhou, X. and Zietara, K. and Ziolkowski, J. and Ziolkowski, P. and Zitelli, V. and Zurbach, C. and Zychowski, P.}, title = {Introducing the CTA concept}, series = {Astroparticle physics}, volume = {43}, journal = {Astroparticle physics}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, organization = {CTA Consortium}, issn = {0927-6505}, doi = {10.1016/j.astropartphys.2013.01.007}, pages = {3 -- 18}, year = {2013}, abstract = {The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project.}, language = {en} } @article{ActisAgnettaAharonianetal.2011, author = {Actis, M. and Agnetta, G. and Aharonian, Felix A. and Akhperjanian, A. G. and Aleksic, J. and Aliu, E. and Allan, D. and Allekotte, I. and Antico, F. and Antonelli, L. 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J. and Hassan, T. and Haubold, T. and Hauser, M. and Hayashida, M. and Heller, R. and Henri, G. and Hermann, G. and Herrero, A. and Hinton, James Anthony and Hoffmann, D. and Hofmann, W. and Hofverberg, P. and Horns, D. and Hrupec, D. and Huan, H. and Huber, B. and Huet, J. -M. and Hughes, G. and Hultquist, K. and Humensky, T. B. and Huppert, J. -F. and Ibarra, A. and Illa, J. M. and Ingjald, J. and Inoue, S. and Inoue, Y. and Ioka, K. and Jablonski, C. and Jacholkowska, A. and Janiak, M. and Jean, P. and Jensen, H. and Jogler, T. and Jung, I. and Kaaret, P. and Kabuki, S. and Kakuwa, J. and Kalkuhl, C. and Kankanyan, R. and Kapala, M. and Karastergiou, A. and Karczewski, M. and Karkar, S. and Karlsson, N. and Kasperek, J. and Katagiri, H. and Katarzynski, K. and Kawanaka, N. and Kedziora, B. and Kendziorra, E. and Khelifi, B. and Kieda, D. and Kifune, T. and Kihm, T. and Klepser, S. and Kluzniak, W. and Knapp, J. and Knappy, A. R. and Kneiske, T. and Knoedlseder, J. and Koeck, F. and Kodani, K. and Kohri, K. and Kokkotas, K. and Komin, N. and Konopelko, A. and Kosack, K. and Kossakowski, R. and Kostka, P. and Kotula, J. and Kowal, G. and Koziol, J. and Kraehenbuehl, T. and Krause, J. and Krawczynski, H. and Krennrich, F. and Kretzschmann, A. and Kubo, H. and Kudryavtsev, V. A. and Kushida, J. and La Barbera, N. and La Parola, V. and La Rosa, G. and Lopez, A. and Lamanna, G. and Laporte, P. and Lavalley, C. and Le Flour, T. and Le Padellec, A. and Lenain, J. -P. and Lessio, L. and Lieunard, B. and Lindfors, E. and Liolios, A. and Lohse, T. and Lombardi, S. and Lopatin, A. and Lorenz, E. and Lubinski, P. and Luz, O. and Lyard, E. and Maccarone, M. C. and Maccarone, T. and Maier, G. and Majumdar, P. and Maltezos, S. and Malkiewicz, P. and Mana, C. and Manalaysay, A. and Maneva, G. and Mangano, A. and Manigot, P. and Marin, J. and Mariotti, M. and Markoff, S. and Martinez, G. and Martinez, M. and Mastichiadis, A. and Matsumoto, H. and Mattiazzo, S. and Mazin, D. and McComb, T. J. L. and McCubbin, N. and McHardy, I. and Medina, C. and Melkumyan, D. and Mendes, A. and Mertsch, P. and Meucci, M. and Michalowski, J. and Micolon, P. and Mineo, T. and Mirabal, N. and Mirabel, F. and Miranda, J. M. and Mirzoyan, R. and Mizuno, T. and Moal, B. and Moderski, R. and Molinari, E. and Monteiro, I. and Moralejo, A. and Morello, C. and Mori, K. and Motta, G. and Mottez, F. and Moulin, Emmanuel and Mukherjee, R. and Munar, P. and Muraishi, H. and Murase, K. and Murphy, A. Stj. and Nagataki, S. and Naito, T. and Nakamori, T. and Nakayama, K. and Naumann, C. L. and Naumann, D. and Nayman, P. and Nedbal, D. and Niedzwiecki, A. and Niemiec, J. and Nikolaidis, A. and Nishijima, K. and Nolan, S. J. and Nowak, N. and O'Brien, P. T. and Ochoa, I. and Ohira, Y. and Ohishi, M. and Ohka, H. and Okumura, A. and Olivetto, C. and Ong, R. A. and Orito, R. and Orr, M. and Osborne, J. P. and Ostrowski, M. and Otero, L. and Otte, A. N. and Ovcharov, E. and Oya, I. and Ozieblo, A. and Paiano, S. and Pallota, J. and Panazol, J. L. and Paneque, D. and Panter, M. and Paoletti, R. and Papyan, G. and Paredes, J. M. and Pareschi, G. and Parsons, R. D. and Arribas, M. Paz and Pedaletti, G. and Pepato, A. and Persic, M. and Petrucci, P. O. and Peyaud, B. and Piechocki, W. and Pita, S. and Pivato, G. and Platos, L. and Platzer, R. and Pogosyan, L. and Pohl, Martin and Pojmanski, G. and Ponz, J. D. and Potter, W. and Prandini, E. and Preece, R. and Prokoph, H. and Puehlhofer, G. and Punch, M. and Quel, E. and Quirrenbach, A. and Rajda, P. and Rando, R. and Rataj, M. and Raue, M. and Reimann, C. and Reimann, O. and Reimer, A. and Reimer, O. and Renaud, M. and Renner, S. and Reymond, J. -M. and Rhode, W. and Ribo, M. and Ribordy, M. and Rico, J. and Rieger, F. and Ringegni, P. and Ripken, J. and Ristori, P. and Rivoire, S. and Rob, L. and Rodriguez, S. and Roeser, U. and Romano, Patrizia and Romero, G. E. and Rosier-Lees, S. and Rovero, A. C. and Roy, F. and Royer, S. and Rudak, B. and Rulten, C. B. and Ruppel, J. and Russo, F. and Ryde, F. and Sacco, B. and Saggion, A. and Sahakian, V. and Saito, K. and Saito, T. and Sakaki, N. and Salazar, E. and Salini, A. and Sanchez, F. and Sanchez Conde, M. A. and Santangelo, Andrea and Santos, E. M. and Sanuy, A. and Sapozhnikov, L. and Sarkar, S. and Scalzotto, V. and Scapin, V. and Scarcioffolo, M. and Schanz, T. and Schlenstedt, S. and Schlickeiser, R. and Schmidt, T. and Schmoll, J. and Schroedter, M. and Schultz, C. and Schultze, J. and Schulz, A. and Schwanke, U. and Schwarzburg, S. and Schweizer, T. and Seiradakis, J. and Selmane, S. and Seweryn, K. and Shayduk, M. and Shellard, R. C. and Shibata, T. and Sikora, M. and Silk, J. and Sillanpaa, A. and Sitarek, J. and Skole, C. and Smith, N. and Sobczynska, D. and Sofo Haro, M. and Sol, H. and Spanier, F. and Spiga, D. and Spyrou, S. and Stamatescu, V. and Stamerra, A. and Starling, R. L. C. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steiner, S. and Stergioulas, N. and Sternberger, R. and Stinzing, F. and Stodulski, M. and Straumann, U. and Suarez, A. and Suchenek, M. and Sugawara, R. and Sulanke, K. H. and Sun, S. and Supanitsky, A. D. and Sutcliffe, P. and Szanecki, M. and Szepieniec, T. and Szostek, A. and Szymkowiak, A. and Tagliaferri, G. and Tajima, H. and Takahashi, H. and Takahashi, K. and Takalo, L. and Takami, H. and Talbot, R. G. and Tam, P. H. and Tanaka, M. and Tanimori, T. and Tavani, M. and Tavernet, J. -P. and Tchernin, C. and Tejedor, L. A. and Telezhinsky, Igor O. and Temnikov, P. and Tenzer, C. and Terada, Y. and Terrier, R. and Teshima, M. and Testa, V. and Tibaldo, L. and Tibolla, O. and Tluczykont, M. and Peixoto, C. J. Todero and Tokanai, F. and Tokarz, M. and Toma, K. and Torres, D. F. and Tosti, G. and Totani, T. and Toussenel, F. and Vallania, P. and Vallejo, G. and van der Walt, J. and van Eldik, C. and Vandenbroucke, J. and Vankov, H. and Vasileiadis, G. and Vassiliev, V. V. and Vegas, I. and Venter, L. and Vercellone, S. and Veyssiere, C. and Vialle, J. P. and Videla, M. and Vincent, P. and Vink, J. and Vlahakis, N. and Vlahos, L. and Vogler, P. and Vollhardt, A. and Volpe, F. and Von Gunten, H. P. and Vorobiov, S. and Wagner, S. and Wagner, R. M. and Wagner, B. and Wakely, S. P. and Walter, P. and Walter, R. and Warwick, R. and Wawer, P. and Wawrzaszek, R. and Webb, N. and Wegner, P. and Weinstein, A. and Weitzel, Q. and Welsing, R. and Wetteskind, H. and White, R. and Wierzcholska, A. and Wilkinson, M. I. and Williams, D. A. and Winde, M. and Wischnewski, R. and Wisniewski, L. and Wolczko, A. and Wood, M. and Xiong, Q. and Yamamoto, T. and Yamaoka, K. and Yamazaki, R. and Yanagita, S. and Yoffo, B. and Yonetani, M. and Yoshida, A. and Yoshida, T. and Yoshikoshi, T. and Zabalza, V. and Zagdanski, A. and Zajczyk, A. and Zdziarski, A. and Zech, Alraune and Zietara, K. and Ziolkowski, P. and Zitelli, V. and Zychowski, P.}, title = {Design concepts for the Cherenkov Telescope Array CTA an advanced facility for ground-based high-energy gamma-ray astronomy}, series = {Experimental astronomy : an international journal on astronomical instrumentation and data analysis}, volume = {32}, journal = {Experimental astronomy : an international journal on astronomical instrumentation and data analysis}, number = {3}, publisher = {Springer}, address = {Dordrecht}, organization = {CTA Consortium}, issn = {0922-6435}, doi = {10.1007/s10686-011-9247-0}, pages = {193 -- 316}, year = {2011}, abstract = {Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA.}, language = {en} } @article{VermaDenkerBalthasaretal.2016, author = {Verma, Meetu and Denker, Carsten and Balthasar, H. and Kuckein, Christoph and Gonz{\´a}lez Manrique, Sergio Javier and Sobotka, M. and Gonzalez, N. Bello and Hoch, S. and Diercke, Andrea and Kummerow, Philipp and Berkefeld, T. and Collados Vera, M. and Feller, A. and Hofmann, A. and Kneer, F. and Lagg, A. and L{\"o}hner-B{\"o}ttcher, J. and Nicklas, H. and Pastor Yabar, A. and Schlichenmaier, R. and Schmidt, D. and Schmidt, W. and Schubert, M. and Sigwarth, M. and Solanki, S. K. and Soltau, D. and Staude, J. and Strassmeier, Klaus G. and Volkmer, R. and von der L{\"u}he, O. and Waldmann, T.}, title = {Horizontal flow fields in and around a small active region The transition period between flux emergence and decay}, series = {Polymers}, volume = {596}, journal = {Polymers}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {1432-0746}, doi = {10.1051/0004-6361/201628380}, pages = {12}, year = {2016}, abstract = {Context. The solar magnetic field is responsible for all aspects of solar activity. Thus, emergence of magnetic flux at the surface is the first manifestation of the ensuing solar activity. Aims. Combining high-resolution and synoptic observations aims to provide a comprehensive description of flux emergence at photospheric level and of the growth process that eventually leads to a mature active region. Methods. The small active region NOAA 12118 emerged on 2014 July 17 and was observed one day later with the 1.5-m GREGOR solar telescope on 2014 July 18. High-resolution time-series of blue continuum and G-band images acquired in the blue imaging channel (BIC) of the GREGOR Fabry-Perot Interferometer (GFPI) were complemented by synoptic line-of-sight magnetograms and continuum images obtained with the Helioseismic and Magnetic Imager (HMI) onboard the Solar Dynamics Observatory (SDO). Horizontal proper motions and horizontal plasma velocities were computed with local correlation tracking (LCT) and the differential affine velocity estimator (DAVE), respectively. Morphological image processing was employed to measure the photometric and magnetic area, magnetic flux, and the separation profile of the emerging flux region during its evolution. Results. The computed growth rates for photometric area, magnetic area, and magnetic flux are about twice as high as the respective decay rates. The space-time diagram using HMI magnetograms of five days provides a comprehensive view of growth and decay. It traces a leaf-like structure, which is determined by the initial separation of the two polarities, a rapid expansion phase, a time when the spread stalls, and a period when the region slowly shrinks again. The separation rate of 0.26 km s(-1) is highest in the initial stage, and it decreases when the separation comes to a halt. Horizontal plasma velocities computed at four evolutionary stages indicate a changing pattern of inflows. In LCT maps we find persistent flow patterns such as outward motions in the outer part of the two major pores, a diverging feature near the trailing pore marking the site of upwelling plasma and flux emergence, and low velocities in the interior of dark pores. We detected many elongated rapidly expanding granules between the two major polarities, with dimensions twice as large as the normal granules.}, language = {en} } @article{GonzalezManriqueKuckeinPastorYabaretal.2016, author = {Gonzalez Manrique, Sergio Javier and Kuckein, Christoph and Pastor Yabar, A. and Collados Vera, M. and Denker, Carsten and Fischer, C. E. and G{\"o}m{\"o}ry, P. and Diercke, Andrea and Gonzalez, N. Bello and Schlichenmaier, R. and Balthasar, H. and Berkefeld, T. and Feller, A. and Hoch, S. and Hofmann, A. and Kneer, F. and Lagg, A. and Nicklas, H. and Orozco Suarez, D. and Schmidt, D. and Schmidt, W. and Sigwarth, M. and Sobotka, M. and Solanki, S. K. and Soltau, D. and Staude, J. and Strassmeier, Klaus G. and Verma, Meetu and Volkmer, R. and von der L{\"u}he, O. and Waldmann, T.}, title = {Fitting peculiar spectral profiles in He I 10830 angstrom absorption features}, series = {Astronomische Nachrichten = Astronomical notes}, volume = {337}, journal = {Astronomische Nachrichten = Astronomical notes}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0004-6337}, doi = {10.1002/asna.201512433}, pages = {1057 -- 1063}, year = {2016}, abstract = {The new generation of solar instruments provides better spectral, spatial, and temporal resolution for a better understanding of the physical processes that take place on the Sun. Multiple-component profiles are more commonly observed with these instruments. Particularly, the He i 10830 triplet presents such peculiar spectral profiles, which give information on the velocity and magnetic fine structure of the upper chromosphere. The purpose of this investigation is to describe a technique to efficiently fit the two blended components of the He i 10830 triplet, which are commonly observed when two atmospheric components are located within the same resolution element. The observations used in this study were taken on 2015 April 17 with the very fast spectroscopic mode of the GREGOR Infrared Spectrograph (GRIS) attached to the 1.5-m GREGOR solar telescope, located at the Observatorio del Teide, Tenerife, Spain. We apply a double-Lorentzian fitting technique using Levenberg-Marquardt least-squares minimization. This technique is very simple and much faster than inversion codes. Line-of-sight Doppler velocities can be inferred for a whole map of pixels within just a few minutes. Our results show sub-and supersonic downflow velocities of up to 32 km s(-1) for the fast component in the vicinity of footpoints of filamentary structures. The slow component presents velocities close to rest. (C) 2016 WILEY-VCH Verlag GmbH\& Co. KGaA, Weinheim}, language = {en} } @article{SramaKruegerYamaguchietal.2012, author = {Srama, Ralf and Krueger, H. and Yamaguchi, T. and Stephan, T. and Burchell, M. and Kearsley, A. T. and Sterken, V. and Postberg, F. and Kempf, S. and Gr{\"u}n, Eberhard and Altobelli, Nicolas and Ehrenfreund, P. and Dikarev, V. and Horanyi, M. and Sternovsky, Zoltan and Carpenter, J. D. and Westphal, A. and Gainsforth, Z. and Krabbe, A. and Agarwal, Jessica and Yano, H. and Blum, J. and Henkel, H. and Hillier, J. and Hoppe, P. and Trieloff, M. and Hsu, S. and Mocker, A. and Fiege, K. and Green, S. F. and Bischoff, A. and Esposito, F. and Laufer, R. and Hyde, T. W. and Herdrich, G. and Fasoulas, S. and Jaeckel, A. and Jones, G. and Jenniskens, P. and Khalisi, E. and Moragas-Klostermeyer, Georg and Spahn, Frank and Keller, H. U. and Frisch, P. and Levasseur-Regourd, A. C. and Pailer, N. and Altwegg, K. and Engrand, C. and Auer, S. and Silen, J. and Sasaki, S. and Kobayashi, M. and Schmidt, J. and Kissel, J. and Marty, B. and Michel, P. and Palumbo, P. and Vaisberg, O. and Baggaley, J. and Rotundi, A. and Roeser, H. P.}, title = {SARIM PLUS-sample return of comet 67P/CG and of interstellar matter}, series = {EXPERIMENTAL ASTRONOMY}, volume = {33}, journal = {EXPERIMENTAL ASTRONOMY}, number = {2-3}, publisher = {SPRINGER}, address = {DORDRECHT}, issn = {0922-6435}, doi = {10.1007/s10686-011-9285-7}, pages = {723 -- 751}, year = {2012}, abstract = {The Stardust mission returned cometary, interplanetary and (probably) interstellar dust in 2006 to Earth that have been analysed in Earth laboratories worldwide. Results of this mission have changed our view and knowledge on the early solar nebula. The Rosetta mission is on its way to land on comet 67P/Churyumov-Gerasimenko and will investigate for the first time in great detail the comet nucleus and its environment starting in 2014. Additional astronomy and planetary space missions will further contribute to our understanding of dust generation, evolution and destruction in interstellar and interplanetary space and provide constraints on solar system formation and processes that led to the origin of life on Earth. One of these missions, SARIM-PLUS, will provide a unique perspective by measuring interplanetary and interstellar dust with high accuracy and sensitivity in our inner solar system between 1 and 2 AU. SARIM-PLUS employs latest in-situ techniques for a full characterisation of individual micrometeoroids (flux, mass, charge, trajectory, composition()) and collects and returns these samples to Earth for a detailed analysis. The opportunity to visit again the target comet of the Rosetta mission 67P/Churyumov-Gerasimeenternko, and to investigate its dusty environment six years after Rosetta with complementary methods is unique and strongly enhances and supports the scientific exploration of this target and the entire Rosetta mission. Launch opportunities are in 2020 with a backup window starting early 2026. The comet encounter occurs in September 2021 and the reentry takes place in early 2024. An encounter speed of 6 km/s ensures comparable results to the Stardust mission.}, language = {en} } @article{EllisBlandHawthornLawrenceetal.2012, author = {Ellis, S. C. and Bland-Hawthorn, Joss and Lawrence, J. and Horton, A. J. and Trinh, C. and Leon-Saval, S. G. and Shortridge, K. and Bryant, J. and Case, S. and Colless, M. and Couch, W. and Freeman, K. and Gers, L. and Glazebrook, K. and Haynes, R. and Lee, S. and L{\"o}hmannsr{\"o}ben, Hans-Gerd and O'Byrne, J. and Miziarski, S. and Roth, M. and Schmidt, B. and Tinney, C. G. and Zheng, J.}, title = {Suppression of the near-infrared OH night-sky lines with fibre Bragg gratings - first results}, series = {Monthly notices of the Royal Astronomical Society}, volume = {425}, journal = {Monthly notices of the Royal Astronomical Society}, number = {3}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {0035-8711}, doi = {10.1111/j.1365-2966.2012.21602.x}, pages = {1682 -- 1695}, year = {2012}, abstract = {The background noise between 1 and 1.8 ?mu m in ground-based instruments is dominated by atmospheric emission from hydroxyl molecules. We have built and commissioned a new instrument, the Gemini Near-infrared OH Suppression Integral Field Unit (IFU) System (GNOSIS), which suppresses 103 OH doublets between 1.47 and 1.7?mu m by a factor of 1000 with a resolving power of 10?000. We present the first results from the commissioning of GNOSIS using the IRIS2 spectrograph at the Anglo-Australian Telescope. We present measurements of sensitivity, background and throughput. The combined throughput of the GNOSIS fore-optics, grating unit and relay optics is 36?per cent, but this could be improved to 46?per cent with a more optimal design. We measure strong suppression of the OH lines, confirming that OH suppression with fibre Bragg gratings will be a powerful technology for low-resolution spectroscopy. The integrated OH suppressed background between 1.5 and 1.7 mu m is reduced by a factor of 9 compared to a control spectrum using the same system without suppression. The potential of low-resolution OH-suppressed spectroscopy is illustrated with example observations of Seyfert galaxies and a low-mass star. The GNOSIS background is dominated by detector dark current below 1.67 mu m and by thermal emission above 1.67 mu m. After subtracting these, we detect an unidentified residual interline component of 860 +/- 210 photons s-1 m-2?arcsec-2?mu m-1, comparable to previous measurements. This component is equally bright in the suppressed and control spectra. We have investigated the possible source of the interline component, but were unable to discriminate between a possible instrumental artefact and intrinsic atmospheric emission. Resolving the source of this emission is crucial for the design of fully optimized OH suppression spectrographs. The next-generation OH suppression spectrograph will be focused on resolving the source of the interline component, taking advantage of better optimization for a fibre Bragg grating feed incorporating refinements of design based on our findings from GNOSIS. We quantify the necessary improvements for an optimal OH suppressing fibre spectrograph design.}, language = {en} } @article{AartsAndersonAndersonetal.2015, author = {Aarts, Alexander A. and Anderson, Joanna E. and Anderson, Christopher J. and Attridge, Peter R. and Attwood, Angela and Axt, Jordan and Babel, Molly and Bahnik, Stepan and Baranski, Erica and Barnett-Cowan, Michael and Bartmess, Elizabeth and Beer, Jennifer and Bell, Raoul and Bentley, Heather and Beyan, Leah and Binion, Grace and Borsboom, Denny and Bosch, Annick and Bosco, Frank A. and Bowman, Sara D. and Brandt, Mark J. and Braswell, Erin and Brohmer, Hilmar and Brown, Benjamin T. and Brown, Kristina and Bruening, Jovita and Calhoun-Sauls, Ann and Callahan, Shannon P. and Chagnon, Elizabeth and Chandler, Jesse and Chartier, Christopher R. and Cheung, Felix and Christopherson, Cody D. and Cillessen, Linda and Clay, Russ and Cleary, Hayley and Cloud, Mark D. and Cohn, Michael and Cohoon, Johanna and Columbus, Simon and Cordes, Andreas and Costantini, Giulio and Alvarez, Leslie D. Cramblet and Cremata, Ed and Crusius, Jan and DeCoster, Jamie and DeGaetano, Michelle A. and Della Penna, Nicolas and den Bezemer, Bobby and Deserno, Marie K. and Devitt, Olivia and Dewitte, Laura and Dobolyi, David G. and Dodson, Geneva T. and Donnellan, M. Brent and Donohue, Ryan and Dore, Rebecca A. and Dorrough, Angela and Dreber, Anna and Dugas, Michelle and Dunn, Elizabeth W. and Easey, Kayleigh and Eboigbe, Sylvia and Eggleston, Casey and Embley, Jo and Epskamp, Sacha and Errington, Timothy M. and Estel, Vivien and Farach, Frank J. and Feather, Jenelle and Fedor, Anna and Fernandez-Castilla, Belen and Fiedler, Susann and Field, James G. and Fitneva, Stanka A. and Flagan, Taru and Forest, Amanda L. and Forsell, Eskil and Foster, Joshua D. and Frank, Michael C. and Frazier, Rebecca S. and Fuchs, Heather and Gable, Philip and Galak, Jeff and Galliani, Elisa Maria and Gampa, Anup and Garcia, Sara and Gazarian, Douglas and Gilbert, Elizabeth and Giner-Sorolla, Roger and Gl{\"o}ckner, Andreas and G{\"o}llner, Lars and Goh, Jin X. and Goldberg, Rebecca and Goodbourn, Patrick T. and Gordon-McKeon, Shauna and Gorges, Bryan and Gorges, Jessie and Goss, Justin and Graham, Jesse and Grange, James A. and Gray, Jeremy and Hartgerink, Chris and Hartshorne, Joshua and Hasselman, Fred and Hayes, Timothy and Heikensten, Emma and Henninger, Felix and Hodsoll, John and Holubar, Taylor and Hoogendoorn, Gea and Humphries, Denise J. and Hung, Cathy O. -Y. and Immelman, Nathali and Irsik, Vanessa C. and Jahn, Georg and Jaekel, Frank and Jekel, Marc and Johannesson, Magnus and Johnson, Larissa G. and Johnson, David J. and Johnson, Kate M. and Johnston, William J. and Jonas, Kai and Joy-Gaba, Jennifer A. and Kappes, Heather Barry and Kelso, Kim and Kidwell, Mallory C. and Kim, Seung Kyung and Kirkhart, Matthew and Kleinberg, Bennett and Knezevic, Goran and Kolorz, Franziska Maria and Kossakowski, Jolanda J. and Krause, Robert Wilhelm and Krijnen, Job and Kuhlmann, Tim and Kunkels, Yoram K. and Kyc, Megan M. and Lai, Calvin K. and Laique, Aamir and Lakens, Daniel and Lane, Kristin A. and Lassetter, Bethany and Lazarevic, Ljiljana B. and LeBel, Etienne P. and Lee, Key Jung and Lee, Minha and Lemm, Kristi and Levitan, Carmel A. and Lewis, Melissa and Lin, Lin and Lin, Stephanie and Lippold, Matthias and Loureiro, Darren and Luteijn, Ilse and Mackinnon, Sean and Mainard, Heather N. and Marigold, Denise C. and Martin, Daniel P. and Martinez, Tylar and Masicampo, E. J. and Matacotta, Josh and Mathur, Maya and May, Michael and Mechin, Nicole and Mehta, Pranjal and Meixner, Johannes and Melinger, Alissa and Miller, Jeremy K. and Miller, Mallorie and Moore, Katherine and M{\"o}schl, Marcus and Motyl, Matt and M{\"u}ller, Stephanie M. and Munafo, Marcus and Neijenhuijs, Koen I. and Nervi, Taylor and Nicolas, Gandalf and Nilsonne, Gustav and Nosek, Brian A. and Nuijten, Michele B. and Olsson, Catherine and Osborne, Colleen and Ostkamp, Lutz and Pavel, Misha and Penton-Voak, Ian S. and Perna, Olivia and Pernet, Cyril and Perugini, Marco and Pipitone, R. Nathan and Pitts, Michael and Plessow, Franziska and Prenoveau, Jason M. and Rahal, Rima-Maria and Ratliff, Kate A. and Reinhard, David and Renkewitz, Frank and Ricker, Ashley A. and Rigney, Anastasia and Rivers, Andrew M. and Roebke, Mark and Rutchick, Abraham M. and Ryan, Robert S. and Sahin, Onur and Saide, Anondah and Sandstrom, Gillian M. and Santos, David and Saxe, Rebecca and Schlegelmilch, Rene and Schmidt, Kathleen and Scholz, Sabine and Seibel, Larissa and Selterman, Dylan Faulkner and Shaki, Samuel and Simpson, William B. and Sinclair, H. Colleen and Skorinko, Jeanine L. M. and Slowik, Agnieszka and Snyder, Joel S. and Soderberg, Courtney and Sonnleitner, Carina and Spencer, Nick and Spies, Jeffrey R. and Steegen, Sara and Stieger, Stefan and Strohminger, Nina and Sullivan, Gavin B. and Talhelm, Thomas and Tapia, Megan and te Dorsthorst, Anniek and Thomae, Manuela and Thomas, Sarah L. and Tio, Pia and Traets, Frits and Tsang, Steve and Tuerlinckx, Francis and Turchan, Paul and Valasek, Milan and Van Aert, Robbie and van Assen, Marcel and van Bork, Riet and van de Ven, Mathijs and van den Bergh, Don and van der Hulst, Marije and van Dooren, Roel and van Doorn, Johnny and van Renswoude, Daan R. and van Rijn, Hedderik and Vanpaemel, Wolf and Echeverria, Alejandro Vasquez and Vazquez, Melissa and Velez, Natalia and Vermue, Marieke and Verschoor, Mark and Vianello, Michelangelo and Voracek, Martin and Vuu, Gina and Wagenmakers, Eric-Jan and Weerdmeester, Joanneke and Welsh, Ashlee and Westgate, Erin C. and Wissink, Joeri and Wood, Michael and Woods, Andy and Wright, Emily and Wu, Sining and Zeelenberg, Marcel and Zuni, Kellylynn}, title = {Estimating the reproducibility of psychological science}, series = {Science}, volume = {349}, journal = {Science}, number = {6251}, publisher = {American Assoc. for the Advancement of Science}, address = {Washington}, organization = {Open Sci Collaboration}, issn = {1095-9203}, doi = {10.1126/science.aac4716}, pages = {8}, year = {2015}, abstract = {Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47\% of original effect sizes were in the 95\% confidence interval of the replication effect size; 39\% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68\% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.}, language = {en} } @misc{ArnisonBibbBierbaumetal.2013, author = {Arnison, Paul G. and Bibb, Mervyn J. and Bierbaum, Gabriele and Bowers, Albert A. and Bugni, Tim S. and Bulaj, Grzegorz and Camarero, Julio A. and Campopiano, Dominic J. and Challis, Gregory L. and Clardy, Jon and Cotter, Paul D. and Craik, David J. and Dawson, Michael and Dittmann-Th{\"u}nemann, Elke and Donadio, Stefano and Dorrestein, Pieter C. and Entian, Karl-Dieter and Fischbach, Michael A. and Garavelli, John S. and Goeransson, Ulf and Gruber, Christian W. and Haft, Daniel H. and Hemscheidt, Thomas K. and Hertweck, Christian and Hill, Colin and Horswill, Alexander R. and Jaspars, Marcel and Kelly, Wendy L. and Klinman, Judith P. and Kuipers, Oscar P. and Link, A. James and Liu, Wen and Marahiel, Mohamed A. and Mitchell, Douglas A. and Moll, Gert N. and Moore, Bradley S. and Mueller, Rolf and Nair, Satish K. and Nes, Ingolf F. and Norris, Gillian E. and Olivera, Baldomero M. and Onaka, Hiroyasu and Patchett, Mark L. and Piel, J{\"o}rn and Reaney, Martin J. T. and Rebuffat, Sylvie and Ross, R. Paul and Sahl, Hans-Georg and Schmidt, Eric W. and Selsted, Michael E. and Severinov, Konstantin and Shen, Ben and Sivonen, Kaarina and Smith, Leif and Stein, Torsten and Suessmuth, Roderich D. and Tagg, John R. and Tang, Gong-Li and Truman, Andrew W. and Vederas, John C. and Walsh, Christopher T. and Walton, Jonathan D. and Wenzel, Silke C. and Willey, Joanne M. and van der Donk, Wilfred A.}, title = {Ribosomally synthesized and post-translationally modified peptide natural products overview and recommendations for a universal nomenclature}, series = {Natural product reports : a journal of current developments in bio-organic chemistry}, volume = {30}, journal = {Natural product reports : a journal of current developments in bio-organic chemistry}, number = {1}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {0265-0568}, doi = {10.1039/c2np20085f}, pages = {108 -- 160}, year = {2013}, abstract = {This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.}, language = {en} } @article{MartinezGonzalezPastorYabarLaggetal.2016, author = {Martinez Gonzalez, M. J. and Pastor Yabar, A. and Lagg, A. and Asensio Ramos, A. and Collados Vera, M. and Solanki, S. K. and Balthasar, H. and Berkefeld, T. and Denker, Carsten and Doerr, H. P. and Feller, A. and Franz, M. and Gonz{\´a}lez Manrique, Sergio Javier and Hofmann, A. and Kneer, F. and Kuckein, Christoph and Louis, R. and von der L{\"u}he, O. and Nicklas, H. and Orozco, D. and Rezaei, R. and Schlichenmaier, R. and Schmidt, D. and Schmidt, W. and Sigwarth, M. and Sobotka, M. and Soltau, D. and Staude, J. and Strassmeier, Klaus G. and Verma, Meetu and Waldman, T. and Volkmer, R.}, title = {Inference of magnetic fields in the very quiet Sun}, series = {Journal of geophysical research : Earth surface}, volume = {596}, journal = {Journal of geophysical research : Earth surface}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {1432-0746}, doi = {10.1051/0004-6361/201628449}, pages = {11}, year = {2016}, abstract = {Context. Over the past 20 yr, the quietest areas of the solar surface have revealed a weak but extremely dynamic magnetism occurring at small scales (<500 km), which may provide an important contribution to the dynamics and energetics of the outer layers of the atmosphere. Understanding this magnetism requires the inference of physical quantities from high-sensitivity spectro-polarimetric data with high spatio-temporal resolution. Aims. We present high-precision spectro-polarimetric data with high spatial resolution (0.4") of the very quiet Sun at 1.56 mu m obtained with the GREGOR telescope to shed some light on this complex magnetism. Methods. We used inversion techniques in two main approaches. First, we assumed that the observed profiles can be reproduced with a constant magnetic field atmosphere embedded in a field-free medium. Second, we assumed that the resolution element has a substructure with either two constant magnetic atmospheres or a single magnetic atmosphere with gradients of the physical quantities along the optical depth, both coexisting with a global stray-light component. Results. Half of our observed quiet-Sun region is better explained by magnetic substructure within the resolution element. However, we cannot distinguish whether this substructure comes from gradients of the physical parameters along the line of sight or from horizontal gradients (across the surface). In these pixels, a model with two magnetic components is preferred, and we find two distinct magnetic field populations. The population with the larger filling factor has very weak (similar to 150 G) horizontal fields similar to those obtained in previous works. We demonstrate that the field vector of this population is not constrained by the observations, given the spatial resolution and polarimetric accuracy of our data. The topology of the other component with the smaller filling factor is constrained by the observations for field strengths above 250 G: we infer hG fields with inclinations and azimuth values compatible with an isotropic distribution. The filling factors are typically below 30\%. We also find that the flux of the two polarities is not balanced. From the other half of the observed quiet-Sun area similar to 50\% are two-lobed Stokes V profiles, meaning that 23\% of the field of view can be adequately explained with a single constant magnetic field embedded in a non-magnetic atmosphere. The magnetic field vector and filling factor are reliable inferred in only 50\% based on the regular profiles. Therefore, 12\% of the field of view harbour hG fields with filling factors typically below 30\%. At our present spatial resolution, 70\% of the pixels apparently are non-magnetised.}, language = {en} } @article{BalthasarGoemoeryGonzalezManriqueetal.2016, author = {Balthasar, H. and G{\"o}m{\"o}ry, P. and Gonz{\´a}lez Manrique, Sergio Javier and Kuckein, Christoph and Kavka, J. and Kucera, A. and Schwartz, P. and Vaskova, R. and Berkefeld, T. and Collados Vera, M. and Denker, Carsten and Feller, A. and Hofmann, A. and Lagg, A. and Nicklas, H. and Suarez, D. and Pastor Yabar, A. and Rezaei, R. and Schlichenmaier, R. and Schmidt, D. and Schmidt, W. and Sigwarth, M. and Sobotka, M. and Solanki, S. K. and Soltau, D. and Staude, J. and Strassmeier, Klaus G. and Volkmer, R. and von der L{\"u}he, O. and Waldmann, T.}, title = {Spectropolarimetric observations of an arch filament system with the GREGOR solar telescope}, series = {Astronomische Nachrichten = Astronomical notes}, volume = {337}, journal = {Astronomische Nachrichten = Astronomical notes}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0004-6337}, doi = {10.1002/asna.201612432}, pages = {1050 -- 1056}, year = {2016}, abstract = {Arch filament systems occur in active sunspot groups, where a fibril structure connects areas of opposite magnetic polarity, in contrast to active region filaments that follow the polarity inversion line. We used the GREGOR Infrared Spectrograph (GRIS) to obtain the full Stokes vector in the spectral lines SiI lambda 1082.7 nm, He I lambda 1083.0 nm, and Ca I lambda 1083.9 nm. We focus on the near-infrared calcium line to investigate the photospheric magnetic field and velocities, and use the line core intensities and velocities of the helium line to study the chromospheric plasma. The individual fibrils of the arch filament system connect the sunspot with patches of magnetic polarity opposite to that of the spot. These patches do not necessarily coincide with pores, where the magnetic field is strongest. Instead, areas are preferred not far from the polarity inversion line. These areas exhibit photospheric downflows of moderate velocity, but significantly higher downflows of up to 30 km s(-1) in the chromospheric helium line. Our findings can be explained with new emerging flux where the matter flows downward along the field lines of rising flux tubes, in agreement with earlier results. (C) 2016 WILEY-VCH Verlag GmbH\& Co. KGaA, Weinheim}, language = {en} } @article{VermaDenkerBoehmetal.2016, author = {Verma, Meetu and Denker, Carsten and B{\"o}hm, F. and Balthasar, H. and Fischer, C. E. and Kuckein, Christoph and Gonzalez, N. Bello and Berkefeld, T. and Collados Vera, M. and Diercke, Andrea and Feller, A. and Gonzalez Manrique, Sergio Javier and Hofmann, A. and Lagg, A. and Nicklas, H. and Orozco Suarez, D. and Pator Yabar, A. and Rezaei, R. and Schlichenmaier, R. and Schmidt, D. and Schmidt, W. and Sigwarth, M. and Sobotka, M. and Solanki, S. K. and Soltau, D. and Staude, J. and Strassmeier, Klaus G. and Volkmer, R. and von der L{\"u}he, O. and Waldmann, T.}, title = {Flow and magnetic field properties in the trailing sunspots of active region NOAA 12396}, series = {Astronomische Nachrichten = Astronomical notes}, volume = {337}, journal = {Astronomische Nachrichten = Astronomical notes}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0004-6337}, doi = {10.1002/asna.201612447}, pages = {1090 -- 1098}, year = {2016}, abstract = {Improved measurements of the photospheric and chromospheric three-dimensional magnetic and flow fields are crucial for a precise determination of the origin and evolution of active regions. We present an illustrative sample of multi-instrument data acquired during a two-week coordinated observing campaign in August 2015 involving, among others, the GREGOR solar telescope (imaging and near-infrared spectroscopy) and the space missions Solar Dynamics Observatory (SDO) and Interface Region Imaging Spectrograph (IRIS). The observations focused on the trailing part of active region NOAA 12396 with complex polarity inversion lines and strong intrusions of opposite polarity flux. The GREGOR Infrared Spectrograph (GRIS) provided Stokes IQUV spectral profiles in the photospheric Si i.1082.7 nm line, the chromospheric He I lambda 1083.0 nm triplet, and the photospheric Ca I lambda 1083.9 nm line. Carefully calibrated GRIS scans of the active region provided maps of Doppler velocity and magnetic field at different atmospheric heights. We compare quick-look maps with those obtained with the " Stokes Inversions based on Response functions" (SIR) code, which furnishes deeper insight into the magnetic properties of the region. We find supporting evidence that newly emerging flux and intruding opposite polarity flux are hampering the formation of penumbrae, i.e., a penumbra fully surrounding a sunspot is only expected after cessation of flux emergence in proximity to the sunspots. (C) 2016 WILEY-VCH Verlag GmbH\& Co.KGaA, Weinheim}, language = {en} } @misc{GorskiJungLietal.2020, author = {Gorski, Mathias and Jung, Bettina and Li, Yong and Matias-Garcia, Pamela R. and Wuttke, Matthias and Coassin, Stefan and Thio, Chris H. L. and Kleber, Marcus E. and Winkler, Thomas W. and Wanner, Veronika and Chai, Jin-Fang and Chu, Audrey Y. and Cocca, Massimiliano and Feitosa, Mary F. and Ghasemi, Sahar and Hoppmann, Anselm and Horn, Katrin and Li, Man and Nutile, Teresa and Scholz, Markus and Sieber, Karsten B. and Teumer, Alexander and Tin, Adrienne and Wang, Judy and Tayo, Bamidele O. and Ahluwalia, Tarunveer S. and Almgren, Peter and Bakker, Stephan J. L. and Banas, Bernhard and Bansal, Nisha and Biggs, Mary L. and Boerwinkle, Eric and B{\"o}ttinger, Erwin and Brenner, Hermann and Carroll, Robert J. and Chalmers, John and Chee, Miao-Li and Chee, Miao-Ling and Cheng, Ching-Yu and Coresh, Josef and de Borst, Martin H. and Degenhardt, Frauke and Eckardt, Kai-Uwe and Endlich, Karlhans and Franke, Andre and Freitag-Wolf, Sandra and Gampawar, Piyush and Gansevoort, Ron T. and Ghanbari, Mohsen and Gieger, Christian and Hamet, Pavel and Ho, Kevin and Hofer, Edith and Holleczek, Bernd and Foo, Valencia Hui Xian and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Josyula, Navya Shilpa and Kahonen, Mika and Khor, Chiea-Chuen and Koenig, Wolfgang and Kramer, Holly and Kraemer, Bernhard K. and Kuehnel, Brigitte and Lange, Leslie A. and Lehtimaki, Terho and Lieb, Wolfgang and Loos, Ruth J. F. and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Milaneschi, Yuri and Mishra, Pashupati P. and Mononen, Nina and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and O'Donoghue, Michelle L. and Orho-Melander, Marju and Pendergrass, Sarah A. and Penninx, Brenda W. J. H. and Preuss, Michael H. and Psaty, Bruce M. and Raffield, Laura M. and Raitakari, Olli T. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Rosenkranz, Alexander R. and Rossing, Peter and Rotter, Jerome and Sabanayagam, Charumathi and Schmidt, Helena and Schmidt, Reinhold and Schoettker, Ben and Schulz, Christina-Alexandra and Sedaghat, Sanaz and Shaffer, Christian M. and Strauch, Konstantin and Szymczak, Silke and Taylor, Kent D. and Tremblay, Johanne and Chaker, Layal and van der Harst, Pim and van der Most, Peter J. and Verweij, Niek and Voelker, Uwe and Waldenberger, Melanie and Wallentin, Lars and Waterworth, Dawn M. and White, Harvey D. and Wilson, James G. and Wong, Tien-Yin and Woodward, Mark and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Yan and Snieder, Harold and Wanner, Christoph and Boger, Carsten A. and Kottgen, Anna and Kronenberg, Florian and Pattaro, Cristian and Heid, Iris M.}, title = {Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Reihe der Digital Engineering Fakult{\"a}t}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Reihe der Digital Engineering Fakult{\"a}t}, number = {19}, doi = {10.25932/publishup-56537}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-565379}, pages = {14}, year = {2020}, abstract = {Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25\% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95\% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.}, language = {en} } @article{GorskiJungLietal.2020, author = {Gorski, Mathias and Jung, Bettina and Li, Yong and Matias-Garcia, Pamela R. and Wuttke, Matthias and Coassin, Stefan and Thio, Chris H. L. and Kleber, Marcus E. and Winkler, Thomas W. and Wanner, Veronika and Chai, Jin-Fang and Chu, Audrey Y. and Cocca, Massimiliano and Feitosa, Mary F. and Ghasemi, Sahar and Hoppmann, Anselm and Horn, Katrin and Li, Man and Nutile, Teresa and Scholz, Markus and Sieber, Karsten B. and Teumer, Alexander and Tin, Adrienne and Wang, Judy and Tayo, Bamidele O. and Ahluwalia, Tarunveer S. and Almgren, Peter and Bakker, Stephan J. L. and Banas, Bernhard and Bansal, Nisha and Biggs, Mary L. and Boerwinkle, Eric and B{\"o}ttinger, Erwin and Brenner, Hermann and Carroll, Robert J. and Chalmers, John and Chee, Miao-Li and Chee, Miao-Ling and Cheng, Ching-Yu and Coresh, Josef and de Borst, Martin H. and Degenhardt, Frauke and Eckardt, Kai-Uwe and Endlich, Karlhans and Franke, Andre and Freitag-Wolf, Sandra and Gampawar, Piyush and Gansevoort, Ron T. and Ghanbari, Mohsen and Gieger, Christian and Hamet, Pavel and Ho, Kevin and Hofer, Edith and Holleczek, Bernd and Foo, Valencia Hui Xian and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Josyula, Navya Shilpa and Kahonen, Mika and Khor, Chiea-Chuen and Koenig, Wolfgang and Kramer, Holly and Kraemer, Bernhard K. and Kuehnel, Brigitte and Lange, Leslie A. and Lehtimaki, Terho and Lieb, Wolfgang and Loos, Ruth J. F. and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Milaneschi, Yuri and Mishra, Pashupati P. and Mononen, Nina and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and O'Donoghue, Michelle L. and Orho-Melander, Marju and Pendergrass, Sarah A. and Penninx, Brenda W. J. H. and Preuss, Michael H. and Psaty, Bruce M. and Raffield, Laura M. and Raitakari, Olli T. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Rosenkranz, Alexander R. and Rossing, Peter and Rotter, Jerome and Sabanayagam, Charumathi and Schmidt, Helena and Schmidt, Reinhold and Schoettker, Ben and Schulz, Christina-Alexandra and Sedaghat, Sanaz and Shaffer, Christian M. and Strauch, Konstantin and Szymczak, Silke and Taylor, Kent D. and Tremblay, Johanne and Chaker, Layal and van der Harst, Pim and van der Most, Peter J. and Verweij, Niek and Voelker, Uwe and Waldenberger, Melanie and Wallentin, Lars and Waterworth, Dawn M. and White, Harvey D. and Wilson, James G. and Wong, Tien-Yin and Woodward, Mark and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Yan and Snieder, Harold and Wanner, Christoph and Boger, Carsten A. and Kottgen, Anna and Kronenberg, Florian and Pattaro, Cristian and Heid, Iris M.}, title = {Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline}, series = {Kidney international : official journal of the International Society of Nephrology}, volume = {99}, journal = {Kidney international : official journal of the International Society of Nephrology}, number = {4}, publisher = {Elsevier}, address = {New York}, organization = {Lifelines Cohort Study
Regeneron Genetics Ctr}, issn = {0085-2538}, doi = {10.1016/j.kint.2020.09.030}, pages = {926 -- 939}, year = {2020}, abstract = {Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25\% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95\% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.}, language = {en} } @article{KoenneckeFollathPontiusetal.2013, author = {K{\"o}nnecke, Rene and Follath, R. and Pontius, N. and Schlappa, J. and Eggenstein, F. and Zeschke, T. and Bischoff, P. and Schmidt, J. -S. and Noll, T. and Trabant, C. and Schreck, S. and Wernet, Ph. and Eisebitt, S. and Senf, F. and Schuessler-Langeheine, Christian and Erko, A. and F{\"o}hlisch, Alexander}, title = {The confocal plane grating spectrometer at BESSY II}, series = {Journal of electron spectroscopy and related phenomena : the international journal on theoretical and experimental aspects of electron spectroscopy}, volume = {188}, journal = {Journal of electron spectroscopy and related phenomena : the international journal on theoretical and experimental aspects of electron spectroscopy}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0368-2048}, doi = {10.1016/j.elspec.2012.11.003}, pages = {133 -- 139}, year = {2013}, abstract = {At BESSY II a confocal plane grating spectrometer for resonant inelastic X-ray scattering (RIXS) is currently under commissioning. The new endstation operates with a source size of 4 x 1 mu m(2) provided by its dedicated beamline. The RIXS-spectrometer covers an energy range from 50 eV to 1000 eV, providing a resolving power E/Delta E of 5000-15,000. The beamline allows full polarization control and gives a photon flux of up to 7 x 10(14) photons/s/0.1 A/0.1\%bandwidth by offering a resolving power E/Delta E of 4000-12,000.}, language = {en} } @article{HohmannBuchmannWittetal.2012, author = {Hohmann, S. and Buchmann, Arlette F. and Witt, S. H. and Rietschel, M. and Jennen-Steinmetz, Christine and Schmidt, M. H. and Esser, G{\"u}nter and Banaschewski, Tobias and Laucht, Manfred}, title = {Increasing association between a neuropeptide Y promoter polymorphism and body mass index during the course of development}, series = {Pediatric obesity}, volume = {7}, journal = {Pediatric obesity}, number = {6}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {2047-6310}, doi = {10.1111/j.2047-6310.2012.00069.x}, pages = {453 -- 460}, year = {2012}, abstract = {Objective: To investigate the association of the neuropeptide Y (NPY) promoter polymorphism rs16147 with body mass index (BMI) during the course of development from infancy to adulthood. Design: Longitudinal, prospective study of a German community sample. Subjects: n = 306 young adults (139 males, 167 females). Measurements: Participants' body weight and height were assessed at the ages of 3 months and 2, 4.5, 8, 11, 15 and 19 years. NPY rs16147 was genotyped. Results: Controlling for a number of possible confounders, homozygote carriers of the rs16147 C allele exhibited significantly lower BMI scores when compared with individuals carrying the T allele. In addition, a significant genotype by age interaction emerged, indicating that the genotype effect increased during the course of development. Conclusions: This is the first longitudinal study to report an association between rs16147 and BMI during childhood and adolescence. The finding that this effect increased during the course of development may either be due to age-dependent alterations in gene expression or to maturation processes within the weight regulation circuits of the central nervous system.}, language = {en} } @misc{MuellerSchoellKloppSchulzeHuisingaetal.2019, author = {M{\"u}ller-Sch{\"o}ll, A. and Klopp-Schulze, Lena and Huisinga, Wilhelm and J{\"o}rger, M. and Neven, P. and Koolen, S. L. and Mathijssen, R. H. J. and Schmidt, S. and Kloft, Charlotte}, title = {Patient-tailored tamoxifen dosing based on an increased quantitative understanding of its complex pharmacokinetics: A novel integrative modelling approach}, series = {Annals of Oncology}, volume = {30}, journal = {Annals of Oncology}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0923-7534}, pages = {1}, year = {2019}, language = {en} } @article{TrinhEllisBlandHawthornetal.2013, author = {Trinh, Christopher Q. and Ellis, Simon C. and Bland-Hawthorn, Joss and Lawrence, Jon S. and Horton, Anthony J. and Leon-Saval, Sergio G. and Shortridge, Keith and Bryant, Julia and Case, Scott and Colless, Matthew and Couch, Warrick and Freeman, Kenneth and L{\"o}hmannsr{\"o}ben, Hans-Gerd and Gers, Luke and Glazebrook, Karl and Haynes, Roger and Lee, Steve and O'Byrne, John and Miziarski, Stan and Roth, Martin M. and Schmidt, Brian and Tinney, Christopher G. and Zheng, Jessica}, title = {Gnosis - the first instrument to use fiber bragg gratings for OH suppression}, series = {The astronomical journal}, volume = {145}, journal = {The astronomical journal}, number = {2}, publisher = {IOP Publ. Ltd.}, address = {Bristol}, issn = {0004-6256}, doi = {10.1088/0004-6256/145/2/51}, pages = {13}, year = {2013}, abstract = {The near-infrared is an important part of the spectrum in astronomy, especially in cosmology because the light from objects in the early universe is redshifted to these wavelengths. However, deep near-infrared observations are extremely difficult to make from ground-based telescopes due to the bright background from the atmosphere. Nearly all of this background comes from the bright and narrow emission lines of atmospheric hydroxyl (OH) molecules. The atmospheric background cannot be easily removed from data because the brightness fluctuates unpredictably on short timescales. The sensitivity of ground-based optical astronomy far exceeds that of near-infrared astronomy because of this long-standing problem. GNOSIS is a prototype astrophotonic instrument that utilizes "OH suppression fibers" consisting of fiber Bragg gratings and photonic lanterns to suppress the 103 brightest atmospheric emission doublets between 1.47 and 1.7 mu m. GNOSIS was commissioned at the 3.9 m Anglo-Australian Telescope with the IRIS2 spectrograph to demonstrate the potential of OH suppression fibers, but may be potentially used with any telescope and spectrograph combination. Unlike previous atmospheric suppression techniques GNOSIS suppresses the lines before dispersion and in a manner that depends purely on wavelength. We present the instrument design and report the results of laboratory and on-sky tests from commissioning. While these tests demonstrated high throughput (approximate to 60\%) and excellent suppression of the skylines by the OH suppression fibers, surprisingly GNOSIS produced no significant reduction in the interline background and the sensitivity of GNOSIS+IRIS2 is about the same as IRIS2. It is unclear whether the lack of reduction in the interline background is due to physical sources or systematic errors as the observations are detector noise dominated. OH suppression fibers could potentially impact ground-based astronomy at the level of adaptive optics or greater. However, until a clear reduction in the interline background and the corresponding increasing in sensitivity is demonstrated optimized OH suppression fibers paired with a fiber-fed spectrograph will at least provide a real benefit at low resolving powers.}, language = {en} } @article{HsuSchmidtKempfetal.2018, author = {Hsu, Hsiang-Wen and Schmidt, J{\"u}rgen and Kempf, Sascha and Postberg, Frank and Moragas-Klostermeyer, Georg and Seiss, Martin and Hoffmann, Holger and Burton, Marcia and Ye, ShengYi and Kurth, William S. and Horanyi, Mihaly and Khawaja, Nozair and Spahn, Frank and Schirdewahn, Daniel and Moore, Luke and Cuzzi, Jeff and Jones, Geraint H. and Srama, Ralf}, title = {In situ collection of dust grains falling from Saturn's rings into its atmosphere}, series = {Science}, volume = {362}, journal = {Science}, number = {6410}, publisher = {American Assoc. for the Advancement of Science}, address = {Washington}, issn = {0036-8075}, doi = {10.1126/science.aat3185}, pages = {49 -- +}, year = {2018}, abstract = {Saturn's main rings are composed of >95\% water ice, and the nature of the remaining few percent has remained unclear. The Cassini spacecraft's traversals between Saturn and its innermost D ring allowed its cosmic dust analyzer (CDA) to collect material released from the main rings and to characterize the ring material infall into Saturn. We report the direct in situ detection of material from Saturn's dense rings by the CDA impact mass spectrometer. Most detected grains are a few tens of nanometers in size and dynamically associated with the previously inferred "ring rain." Silicate and water-ice grains were identified, in proportions that vary with latitude. Silicate grains constitute up to 30\% of infalling grains, a higher percentage than the bulk silicate content of the rings.}, language = {en} } @article{HoermanndosSantosMorkischetal.2017, author = {H{\"o}rmann, Simon and dos Santos, Luara Ferreira and Morkisch, Nadine and Jettkowski, Katrin and Sillis, Moran and Devan, Hemakumar and Kanagasabai, Parimala S. and Schmidt, Henning and Kr{\"u}ger, J{\"o}rg and Dohle, Christian and Regenbrecht, Holger and Hale, Leigh and Cutfield, Nicholas J.}, title = {Computerised mirror therapy with Augmented Reflection Technology for early stroke rehabilitation}, series = {Disability and rehabilitation : an international, multidisciplinary journal}, volume = {39}, journal = {Disability and rehabilitation : an international, multidisciplinary journal}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {0963-8288}, doi = {10.1080/09638288.2017.1291765}, pages = {1503 -- 1514}, year = {2017}, abstract = {Purpose: New rehabilitation strategies for post-stroke upper limb rehabilitation employing visual stimulation show promising results, however, cost-efficient and clinically feasible ways to provide these interventions are still lacking. An integral step is to translate recent technological advances, such as in virtual and augmented reality, into therapeutic practice to improve outcomes for patients. This requires research on the adaptation of the technology for clinical use as well as on the appropriate guidelines and protocols for sustainable integration into therapeutic routines. Here, we present and evaluate a novel and affordable augmented reality system (Augmented Reflection Technology, ART) in combination with a validated mirror therapy protocol for upper limb rehabilitation after stroke. Results: The results showed that the combination and application of the Berlin Protocol for Mirror Therapy together with ART was feasible for clinical use. This combination was integrated into the therapeutic plan of subacute stroke patients at the two clinical locations where the second part of this research was conducted. Conclusions: Our findings pave the way for using technology to provide mirror therapy in clinical settings and show potential for the more effective use of inpatient time and enhanced recoveries for patients. IMPLICATIONS FOR REHABILITATION Computerised Mirror Therapy is feasible for clinical use Augmented Reflection Technology can be integrated as an adjunctive therapeutic intervention for subacute stroke patients in an inpatient setting Virtual Rehabilitation devices such as Augmented Reflection Technology have considerable potential to enhance stroke rehabilitation}, language = {en} } @misc{MegowRoehrSchmidtamBuschetal.2015, author = {Megow, J{\"o}rg and R{\"o}hr, Merle I. S. and Schmidt am Busch, Marcel and Renger, Thomas and Mitrić, Roland and Kirstein, Stefan and Rabe, J{\"u}rgen P. and May, Volkhard}, title = {Site-dependence of van der Waals interaction explains exciton spectra of double-walled tubular J-aggregates}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-79978}, pages = {6741 -- 6747}, year = {2015}, abstract = {The simulation of the optical properties of supramolecular aggregates requires the development of methods, which are able to treat a large number of coupled chromophores interacting with the environment. Since it is currently not possible to treat large systems by quantum chemistry, the Frenkel exciton model is a valuable alternative. In this work we show how the Frenkel exciton model can be extended in order to explain the excitonic spectra of a specific double-walled tubular dye aggregate explicitly taking into account dispersive energy shifts of ground and excited states due to van der Waals interaction with all surrounding molecules. The experimentally observed splitting is well explained by the site-dependent energy shift of molecules placed at the inner or outer side of the double-walled tube, respectively. Therefore we can conclude that inclusion of the site-dependent dispersive effect in the theoretical description of optical properties of nanoscaled dye aggregates is mandatory.}, language = {en} } @article{MegowRoehrSchmidtamBuschetal.2015, author = {Megow, J{\"o}rg and R{\"o}hr, Merle I. S. and Schmidt am Busch, Marcel and Renger, Thomas and Mitrić, Roland and Kirstein, Stefan and Rabe, J{\"u}rgen P. and May, Volkhard}, title = {Site-dependence of van der Waals interaction explains exciton spectra of double-walled tubular J-aggregates}, series = {Physical chemistry, chemical physics : PCCP ; a journal of European chemical societies}, volume = {17}, journal = {Physical chemistry, chemical physics : PCCP ; a journal of European chemical societies}, number = {10}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1463-9084}, doi = {10.1039/c4cp05945j}, pages = {6741 -- 6747}, year = {2015}, abstract = {The simulation of the optical properties of supramolecular aggregates requires the development of methods, which are able to treat a large number of coupled chromophores interacting with the environment. Since it is currently not possible to treat large systems by quantum chemistry, the Frenkel exciton model is a valuable alternative. In this work we show how the Frenkel exciton model can be extended in order to explain the excitonic spectra of a specific double-walled tubular dye aggregate explicitly taking into account dispersive energy shifts of ground and excited states due to van der Waals interaction with all surrounding molecules. The experimentally observed splitting is well explained by the site-dependent energy shift of molecules placed at the inner or outer side of the double-walled tube, respectively. Therefore we can conclude that inclusion of the site-dependent dispersive effect in the theoretical description of optical properties of nanoscaled dye aggregates is mandatory.}, language = {en} } @article{AllenSchmidtEbelingetal.2004, author = {Allen, S. W. and Schmidt, Robert W. and Ebeling, H. and Fabian, A. C. and van Speybroeck, L.}, title = {Constraints on dark energy from Chandra observations of the largest relaxed galaxy clusters}, issn = {0035-8711}, year = {2004}, abstract = {We present constraints on the mean dark energy density, Omega(X) and dark energy equation of state parameter, w(X), based on Chandra measurements of the X-ray gas mass fraction in 26 X-ray luminous, dynamically relaxed galaxy clusters spanning the redshift range 0.07 < z < 0.9. Under the assumption that the X-ray gas mass fraction measured within r(2500) is constant with redshift and using only weak priors on the Hubble constant and mean baryon density of the Universe, we obtain a clear detection of the effects of dark energy on the distances to the clusters, confirming (at comparable significance) previous results from Type la supernovae studies. For a standard Lambda cold dark matter (CDM) cosmology with the curvature Omega(K) included as a free parameter, we find Omega(Lambda) = 0.94(-0.23)(+0.21) (68 per cent confidence limits). We also examine extended XCDM dark energy models. Combining the Chandra data with independent constraints from cosmic microwave background experiments, we find Omega(X) = 0.75 +/- 0.04, Omega(m) = 0.26(- 0.04)(+0.06) and w(X) =-1.26 +/- 0.24. Imposing the prior constraint w(X) > -1, the same data require w(X) < -0.7 at 95 per cent confidence. Similar results on the mean matter density and dark energy equation of state parameter, \&UOmega;(m) = 0.24 ± 0.04 and w(X) 1.20(-0.28)(+0.24), are obtained by replacing the cosmic microwave background data with standard priors on the Hubble constant and mean baryon density and assuming a flat geometry}, language = {en} } @article{SchmidtAllenFabian2004, author = {Schmidt, Robert W. and Allen, S. W. and Fabian, A. C.}, title = {An improved approach to measuring H-0 using X-ray and SZ observations of galaxy clusters}, issn = {0035-8711}, year = {2004}, abstract = {We present an improved method for predicting the Sunyaev-Zeldovich (SZ) effect in galaxy clusters from spatially resolved, spectroscopic X-ray data. Using the deprojected electron density and temperature profiles measured within a fraction of the virial radius, and assuming a Navarro-Frenk-White mass model, we show how the pressure profile of the X-ray gas can be extrapolated to large radii, allowing the Comptonization parameter profile for the cluster to be predicted precisely. We apply our method to Chandra observations of three X-ray-luminous, dynamically relaxed clusters with published SZ data: RX J1347.5-1145, Abell 1835 and Abell 478. Combining the predicted and observed SZ signals, we determine improved estimates for the Hubble constant from each cluster and obtain a weighted mean of H (0) = 69 +/- 8 km s(-1) Mpc(-1) for a cosmology with Omega(m) = 0.3 and Omega(Lambda) = 0.7. This result is in good agreement with independent findings from the Hubble Key Project and the combination of cosmic microwave background and galaxy cluster data}, language = {en} } @article{RickertLendleinSchmidtetal.2003, author = {Rickert, D. and Lendlein, Andreas and Schmidt, A. M. and Kelch, S. and Roehlke, W. and Fuhrmann, R. and Franke, R. P.}, title = {In vitro cytotoxicity testing of AB-polymer networks based on oligo(epsilon-caprolactone) segments after different sterilization techniques}, year = {2003}, language = {en} } @misc{AndersonBahnikBarnettCowanetal.2016, author = {Anderson, Christopher J. and Bahnik, Stepan and Barnett-Cowan, Michael and Bosco, Frank A. and Chandler, Jesse and Chartier, Christopher R. and Cheung, Felix and Christopherson, Cody D. and Cordes, Andreas and Cremata, Edward J. and Della Penna, Nicolas and Estel, Vivien and Fedor, Anna and Fitneva, Stanka A. and Frank, Michael C. and Grange, James A. and Hartshorne, Joshua K. and Hasselman, Fred and Henninger, Felix and van der Hulst, Marije and Jonas, Kai J. and Lai, Calvin K. and Levitan, Carmel A. and Miller, Jeremy K. and Moore, Katherine S. and Meixner, Johannes M. and Munafo, Marcus R. and Neijenhuijs, Koen I. and Nilsonne, Gustav and Nosek, Brian A. and Plessow, Franziska and Prenoveau, Jason M. and Ricker, Ashley A. and Schmidt, Kathleen and Spies, Jeffrey R. and Stieger, Stefan and Strohminger, Nina and Sullivan, Gavin B. and van Aert, Robbie C. M. and van Assen, Marcel A. L. M. and Vanpaemel, Wolf and Vianello, Michelangelo and Voracek, Martin and Zuni, Kellylynn}, title = {Response to Comment on "Estimating the reproducibility of psychological science"}, series = {Science}, volume = {351}, journal = {Science}, publisher = {American Assoc. for the Advancement of Science}, address = {Washington}, issn = {0036-8075}, doi = {10.1126/science.aad9163}, pages = {1162 -- 1165}, year = {2016}, abstract = {Gilbert et al. conclude that evidence from the Open Science Collaboration's Reproducibility Project: Psychology indicates high reproducibility, given the study methodology. Their very optimistic assessment is limited by statistical misconceptions and by causal inferences from selectively interpreted, correlational data. Using the Reproducibility Project: Psychology data, both optimistic and pessimistic conclusions about reproducibility are possible, and neither are yet warranted.}, language = {en} } @article{PerringBernhardtRoemermannBaetenetal.2018, author = {Perring, Michael P. and Bernhardt-Roemermann, Markus and Baeten, Lander and Midolo, Gabriele and Blondeel, Haben and Depauw, Leen and Landuyt, Dries and Maes, Sybryn L. and De Lombaerde, Emiel and Caron, Maria Mercedes and Vellend, Mark and Brunet, Joerg and Chudomelova, Marketa and Decocq, Guillaume and Diekmann, Martin and Dirnboeck, Thomas and Doerfler, Inken and Durak, Tomasz and De Frenne, Pieter and Gilliam, Frank S. and Hedl, Radim and Heinken, Thilo and Hommel, Patrick and Jaroszewicz, Bogdan and Kirby, Keith J. and Kopecky, Martin and Lenoir, Jonathan and Li, Daijiang and Malis, Frantisek and Mitchell, Fraser J. G. and Naaf, Tobias and Newman, Miles and Petrik, Petr and Reczynska, Kamila and Schmidt, Wolfgang and Standovar, Tibor and Swierkosz, Krzysztof and Van Calster, Hans and Vild, Ondrej and Wagner, Eva Rosa and Wulf, Monika and Verheyen, Kris}, title = {Global environmental change effects on plant community composition trajectories depend upon management legacies}, series = {Global change biology}, volume = {24}, journal = {Global change biology}, number = {4}, publisher = {Wiley}, address = {Hoboken}, issn = {1354-1013}, doi = {10.1111/gcb.14030}, pages = {1722 -- 1740}, year = {2018}, abstract = {The contemporary state of functional traits and species richness in plant communities depends on legacy effects of past disturbances. Whether temporal responses of community properties to current environmental changes are altered by such legacies is, however, unknown. We expect global environmental changes to interact with land-use legacies given different community trajectories initiated by prior management, and subsequent responses to altered resources and conditions. We tested this expectation for species richness and functional traits using 1814 survey-resurvey plot pairs of understorey communities from 40 European temperate forest datasets, syntheses of management transitions since the year 1800, and a trait database. We also examined how plant community indicators of resources and conditions changed in response to management legacies and environmental change. Community trajectories were clearly influenced by interactions between management legacies from over 200 years ago and environmental change. Importantly, higher rates of nitrogen deposition led to increased species richness and plant height in forests managed less intensively in 1800 (i.e., high forests), and to decreases in forests with a more intensive historical management in 1800 (i.e., coppiced forests). There was evidence that these declines in community variables in formerly coppiced forests were ameliorated by increased rates of temperature change between surveys. Responses were generally apparent regardless of sites' contemporary management classifications, although sometimes the management transition itself, rather than historic or contemporary management types, better explained understorey responses. Main effects of environmental change were rare, although higher rates of precipitation change increased plant height, accompanied by increases in fertility indicator values. Analysis of indicator values suggested the importance of directly characterising resources and conditions to better understand legacy and environmental change effects. Accounting for legacies of past disturbance can reconcile contradictory literature results and appears crucial to anticipating future responses to global environmental change.}, language = {en} } @article{WalzSchmidtRuizFrauetal.2019, author = {Walz, Ariane and Schmidt, Katja and Ruiz-Frau, Ana and Nicholas, Kimberly A. and Bierry, Adeline and Lentsch, Aster de Vries and Dyankov, Apostol and Joyce, Deirdre and Liski, Anja H. and Marba, Nuria and Rosario, Ines T. and Scholte, Samantha S. K.}, title = {Sociocultural valuation of ecosystem services for operational ecosystem management: mapping applications by decision contexts in Europe}, series = {Regional environmental change}, volume = {19}, journal = {Regional environmental change}, number = {8}, publisher = {Springer}, address = {Heidelberg}, issn = {1436-3798}, doi = {10.1007/s10113-019-01506-7}, pages = {2245 -- 2259}, year = {2019}, abstract = {Sociocultural valuation (SCV) of ecosystem services (ES) discloses the principles, importance or preferences expressed by people towards nature. Although ES research has increasingly addressed sociocultural values in past years, little effort has been made to systematically review the components of sociocultural valuation applications for different decision contexts (i.e. awareness raising, accounting, priority setting, litigation and instrument design). In this analysis, we investigate the characteristics of 48 different sociocultural valuation applications—characterised by unique combinations of decision context, methods, data collection formats and participants—across ten European case studies. Our findings show that raising awareness for the sociocultural value of ES by capturing people's perspective and establishing the status quo, was found the most frequent decision context in case studies, followed by priority setting and instrument development. Accounting and litigation issues were not addressed in any of the applications. We reveal that applications for particular decision contexts are methodologically similar, and that decision contexts determine the choice of methods, data collection formats and participants involved. Therefore, we conclude that understanding the decision context is a critical first step to designing and carrying out fit-for-purpose sociocultural valuation of ES in operational ecosystem management.}, language = {en} } @article{RusakTanentzapKlugetal.2018, author = {Rusak, James A. and Tanentzap, Andrew J. and Klug, Jennifer L. and Rose, Kevin C. and Hendricks, Susan P. and Jennings, Eleanor and Laas, Alo and Pierson, Donald C. and Ryder, Elizabeth and Smyth, Robyn L. and White, D. S. and Winslow, Luke A. and Adrian, Rita and Arvola, Lauri and de Eyto, Elvira and Feuchtmayr, Heidrun and Honti, Mark and Istvanovics, Vera and Jones, Ian D. and McBride, Chris G. and Schmidt, Silke Regina and Seekell, David and Staehr, Peter A. and Guangwei, Zhu}, title = {Wind and trophic status explain within and among-lake variability of algal biomass}, series = {Limnology and oceanography letters / ASLO, Association for the Sciences of Limnology and Oceanography}, volume = {3}, journal = {Limnology and oceanography letters / ASLO, Association for the Sciences of Limnology and Oceanography}, number = {6}, publisher = {Wiley}, address = {Hoboken}, issn = {2378-2242}, doi = {10.1002/lol2.10093}, pages = {409 -- 418}, year = {2018}, abstract = {Phytoplankton biomass and production regulates key aspects of freshwater ecosystems yet its variability and subsequent predictability is poorly understood. We estimated within-lake variation in biomass using high-frequency chlorophyll fluorescence data from 18 globally distributed lakes. We tested how variation in fluorescence at monthly, daily, and hourly scales was related to high-frequency variability of wind, water temperature, and radiation within lakes as well as productivity and physical attributes among lakes. Within lakes, monthly variation dominated, but combined daily and hourly variation were equivalent to that expressed monthly. Among lakes, biomass variability increased with trophic status while, within-lake biomass variation increased with increasing variability in wind speed. Our results highlight the benefits of high-frequency chlorophyll monitoring and suggest that predicted changes associated with climate, as well as ongoing cultural eutrophication, are likely to substantially increase the temporal variability of algal biomass and thus the predictability of the services it provides.}, language = {en} } @article{AldorettaStLouisRichardsonetal.2016, author = {Aldoretta, E. J. and St-Louis, N. and Richardson, N. D. and Moffat, Anthony F. J. and Eversberg, T. and Hill, G. M. and Shenar, Tomer and Artigau, E. and Gauza, B. and Knapen, J. H. and Kubat, Jiř{\´i} and Kubatova, Brankica and Maltais-Tariant, R. and Munoz, M. and Pablo, H. and Ramiaramanantsoa, T. and Richard-Laferriere, A. and Sablowski, D. P. and Simon-Diaz, S. and St-Jean, L. and Bolduan, F. and Dias, F. M. and Dubreuil, P. and Fuchs, D. and Garrel, T. and Grutzeck, G. and Hunger, T. and Kuesters, D. and Langenbrink, M. and Leadbeater, R. and Li, D. and Lopez, A. and Mauclaire, B. and Moldenhawer, T. and Potter, M. and dos Santos, E. M. and Schanne, L. and Schmidt, J. and Sieske, H. and Strachan, J. and Stinner, E. and Stinner, P. and Stober, B. and Strandbaek, K. and Syder, T. and Verilhac, D. and Waldschlaeger, U. and Weiss, D. and Wendt, A.}, title = {An extensive spectroscopic time series of three Wolf-Rayet stars - I. The lifetime of large-scale structures in the wind of WR 134}, series = {Monthly notices of the Royal Astronomical Society}, volume = {460}, journal = {Monthly notices of the Royal Astronomical Society}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0035-8711}, doi = {10.1093/mnras/stw1188}, pages = {3407 -- 3417}, year = {2016}, abstract = {During the summer of 2013, a 4-month spectroscopic campaign took place to observe the variabilities in three Wolf-Rayet stars. The spectroscopic data have been analysed for WR 134 (WN6b), to better understand its behaviour and long-term periodicity, which we interpret as arising from corotating interaction regions (CIRs) in the wind. By analysing the variability of the He ii lambda 5411 emission line, the previously identified period was refined to P = 2.255 +/- 0.008 (s.d.) d. The coherency time of the variability, which we associate with the lifetime of the CIRs in the wind, was deduced to be 40 +/- 6 d, or similar to 18 cycles, by cross-correlating the variability patterns as a function of time. When comparing the phased observational grey-scale difference images with theoretical grey-scales previously calculated from models including CIRs in an optically thin stellar wind, we find that two CIRs were likely present. A separation in longitude of Delta I center dot a parts per thousand integral 90A degrees was determined between the two CIRs and we suggest that the different maximum velocities that they reach indicate that they emerge from different latitudes. We have also been able to detect observational signatures of the CIRs in other spectral lines (C iv lambda lambda 5802,5812 and He i lambda 5876). Furthermore, a DAC was found to be present simultaneously with the CIR signatures detected in the He i lambda 5876 emission line which is consistent with the proposed geometry of the large-scale structures in the wind. Small-scale structures also show a presence in the wind, simultaneously with the larger scale structures, showing that they do in fact co-exist.}, language = {en} } @article{MarzoliTombesiCiaramicolietal.2009, author = {Marzoli, Irene and Tombesi, Paolo and Ciaramicoli, Giacomo and Werth, Guenther and Bushev, Pavel and Stahl, S. and Schmidt-Kaler, Ferdinand and Hellwig, Michael and Henkel, Carsten and Marx, Gerrit and Jex, Igor and Stachowska, Ewa and Szawiola, Gustaw and Walaszyk, Adrian}, title = {Experimental and theoretical challenges for the trapped electron quantum computer}, issn = {0953-4075}, doi = {10.1088/0953-4075/42/15/154010}, year = {2009}, abstract = {We discuss quantum information processing with trapped electrons. After recalling the operation principle of planar Penning traps, we sketch the experimental conditions to load, cool and detect single electrons. Here we present a detailed investigation of a scalable scheme including feasibility studies and the analysis of all important elements, relevant for the experimental stage. On the theoretical side, we discuss different methods to couple electron qubits. We estimate the relevant qubit coherence times and draw implications for the experimental setting. A critical assessment of quantum information processing with trapped electrons concludes the paper.}, language = {en} } @article{GoldmannMahlstedtJanietzetal.1998, author = {Goldmann, Daniela and Mahlstedt, S. and Janietz, Dietmar and Busch, P. and Schmidt, C. and Stracke, A. and Wendorff, Joachim Heinz}, title = {Mesomorphic donor-acceptor twin molecules with covalently linked sheet-like pentaalkyne and nitrofluorenone subunits}, year = {1998}, language = {en} } @article{LauchtTreutleinBlomeyeretal.2009, author = {Laucht, Manfred and Treutlein, Jens and Blomeyer, Dorothea and Buchmann, Arlette F. and Schmid, Brigitte and Becker, Katja and Zimmermann, Ulrich S. and Schmidt, Martin H. and Esser, G{\"u}nter and Rietschel, Marcella and Banaschewski, Tobias}, title = {Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology : evidence from a high-risk community sample of young adults}, issn = {1461-1457}, doi = {10.1017/S1461145708009875}, year = {2009}, abstract = {Previous research examining gene-environment interaction (G x E) with regard to vulnerability to depression and anxiety has yielded conflicting results. The present study was designed to further investigate G x F between 5-HTTLPR and exposure to environmental adversity, using different phenotypic and genotypic characterizations as well as different types of adversity within a prospective study design. Data were available from an ongoing epidemiological cohort Study following the outcome of early risk factors from birth to adulthood. At age 19 yr, 309 participants (142 males, 167 females) were characterized on measures of depression and anxiety through interview and questionnaire (DSM-IV diagnosis, Beck Depression Inventory, Harm Avoidance). Environmental adversity was assessed at birth (family adversity), and at age 19 yr (stressful life events). Bi- and tri-allelic 5-HTTLPR genotypes were obtained from genomic DNA. Results indicated that depression and anxiety in 19-yr-olds were strongly associated with both family adversity and stressful life events. Individuals with the LL genotype of 5-HTTLPR who were exposed to high family adversity displayed significantly higher rates of depressive or anxiety disorders and had more depressive symptoms than those without either condition. This G x E replicates recent findings from an epidemiological cohort study of adolescents but is in contrast to many previous reports suggesting an interaction with the S allele. No evidence for G x E was obtained with regard to current stressful life events and trait anxiety. One possible source for the conflicting findings might be attributed to heterogeneity in depression phenotypes and environmental adversity.}, language = {en} } @article{LauchtTreutleinSchmidetal.2009, author = {Laucht, Manfred and Treutlein, Jens and Schmid, Brigitte and Blomeyer, Dorothea and Becker, Katja and Buchmann, Arlette F. and Schmidt, Martin H. and Esser, G{\"u}nter and Jennen-Steinmetz, Christine and Rietschel, Marcella and Zimmermann, Ulrich S. and Banaschewski, Tobias}, title = {Impact of psychosocial adversity on alcohol intake in young adults : moderation by the LL genotype of the serotonin transporter polymorphism}, issn = {0006-3223}, doi = {10.1016/j.biopsych.2009.02.010}, year = {2009}, abstract = {Background: Evidence from animal studies supports a role for serotonin transporter gene promoter polymorphism (5-HTTLPR) gene-environment interaction (G X E) in the development of excessive alcohol intake. Few studies in humans have been conducted on this topic, yielding inconsistent results. The present study aims to further explore G x E between 5-HTTLPR and exposure to psychosocial adversity on alcohol consumption in a high-risk community sample of young adults. Methods: Data were collected as part of the Mannheim Study of Children at Risk, an ongoing epidemiological cohort study following the outcome of early risk factors from birth into young adulthood. At age 19 years, 309 participants (142 male participants, 167 female participants) were genotyped for the biallelic and triallelic 5-HTTLPR and were administered a 45-day alcohol timeline follow-back interview, providing measures of the total number of drinks and the number of binge drinking days. Psychosocial adversity was assessed at birth (family adversity) and at age 19 (negative life events). Results: In contrast to various previous reports, a significant G x E emerged, indicating that, when exposed to high psychosocial adversity, individuals with the LL genotype of 5-HTTLPR exhibited more hazardous drinking than those carrying the S allele or those without exposure to adversity. This effect, which was confined to male participants, held both for different classifications of 5-HTTLPR and different types of adversity. Conclusions: One explanation for the discrepant results might be heterogeneity in alcohol phenotypes. While the L allele relates more strongly to early-onset alcoholism, the S allele may be linked more closely to alcohol use associated with anxiety and depression.}, language = {en} } @article{TiscarenoMitchellMurrayetal.2013, author = {Tiscareno, Matthew S. and Mitchell, Colin J. and Murray, Carl D. and Di Nino, Daiana and Hedman, Matthew M. and Schmidt, J{\"u}rgen and Burns, Joseph A. and Cuzzi, Jeffrey N. and Porco, Carolyn C. and Beurle, Kevin and Evans, Michael W.}, title = {Observations of Ejecta clouds produced by impacts onto Saturn's rings}, series = {Science}, volume = {340}, journal = {Science}, number = {6131}, publisher = {American Assoc. for the Advancement of Science}, address = {Washington}, issn = {0036-8075}, doi = {10.1126/science.1233524}, pages = {460 -- 464}, year = {2013}, abstract = {We report observations of dusty clouds in Saturn's rings, which we interpret as resulting from impacts onto the rings that occurred between 1 and 50 hours before the clouds were observed. The largest of these clouds was observed twice; its brightness and cant angle evolved in a manner consistent with this hypothesis. Several arguments suggest that these clouds cannot be due to the primary impact of one solid meteoroid onto the rings, but rather are due to the impact of a compact stream of Saturn-orbiting material derived from previous breakup of a meteoroid. The responsible interplanetary meteoroids were initially between 1 centimeter and several meters in size, and their influx rate is consistent with the sparse prior knowledge of smaller meteoroids in the outer solar system.}, language = {en} } @article{JonesArridgeCoatesetal.2009, author = {Jones, Geraint H. and Arridge, Christopher S. and Coates, Andrew J. and Lewis, Gethyn R. and Kanani, Sheila and Wellbrock, Anne and Young, David T. and Crary, Frank J. and Tokar, Robert L. and Wilson, R. J. and Hill, Thomas W. and Johnson, Robert E. and Mitchell, Donald G. and Schmidt, J{\"u}rgen and Kempf, Sascha and Beckmann, Uwe and Russell, Christopher T. and Jia, Y. D. and Dougherty, Michele K. and Waite, J. Hunter and Magee, Brian A.}, title = {Fine jet structure of electrically charged grains in Enceladus' plume}, issn = {0094-8276}, doi = {10.1029/2009gl038284}, year = {2009}, abstract = {By traversing the plume erupting from high southern latitudes on Saturn's moon Enceladus, Cassini orbiter instruments can directly sample the material therein. Cassini Plasma Spectrometer, CAPS, data show that a major plume component comprises previously-undetected particles of nanometer scales and larger that bridge the mass gap between previously observed gaseous species and solid icy grains. This population is electrically charged both negative and positive, indicating that subsurface triboelectric charging, i.e., contact electrification of condensed plume material may occur through mutual collisions within vents. The electric field of Saturn's magnetosphere controls the jets' morphologies, separating particles according to mass and charge. Fine-scale structuring of these particles' spatial distribution correlates with discrete plume jets' sources, and reveals locations of other possible active regions. The observed plume population likely forms a major component of high velocity nanometer particle streams detected outside Saturn's magnetosphere.}, language = {en} } @article{SchmidHohmBlomeyeretal.2007, author = {Schmid, Brigitte and Hohm, Erika and Blomeyer, Dorothea and Zimmermann, Ulrich S. and Schmidt, Martin H. and Esser, G{\"u}nter and Laucht, Manfred}, title = {Concurrent alcohol and tobacco use during early adolescence characterizes a group at risk}, issn = {0735-0414}, doi = {10.1093/alcalc/agm024}, year = {2007}, abstract = {Aims: To investigate whether concurrent alcohol and tobacco use during early adolescence characterizes a subgroup that differs from users of one substance only regarding several risk factors for later substance use problems. Methods: Participants were from a prospective longitudinal cohort study of 384 children at risk for later psychopathology, with the majority being born with obstetric complications and psychosocial adversities. Assessments of adolescent drug consumption and related intrapersonal characteristics were obtained at age 15. Results: Compared to consumers of alcohol only, 15-year-olds drinking and smoking during the same time period (past 4 weeks) had significantly higher levels of consumption and more excessive use of alcohol, started drinking at an earlier age, had higher scores on the Fagerstrom Test for Nicotine Dependence, and more cannabis use. This group could be distinguished from users of alcohol only by higher novelty seeking and more positive alcohol effect expectancies. Compared to consumers of tobacco only, concurrent users reported higher nicotine dependence and more cannabis use. No significant differences were observed regarding frequency and age at initiation of tobacco use, tobacco-related sensitivity, self- efficacy and instrumentality as well as novelty seeking. Conclusions: Concurrent alcohol and tobacco use during early adolescence is associated with characteristics that are well known as risk factors for later alcohol use problems and dependence and that should be targeted by prevention programs.}, language = {en} } @article{SchmidBlomeyerBeckeretal.2009, author = {Schmid, Brigitte and Blomeyer, Dorothea and Becker, Katja and Treutlein, Jens and Zimmermann, Ulrich S. and Buchmann, Arlette F. and Schmidt, Martin H. and Esser, G{\"u}nter and Banaschewski, Tobias and Rietschel, Marcella and Laucht, Manfred}, title = {The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19-year-olds}, issn = {1355-6215}, doi = {10.1111/j.1369-1600.2009.00171.x}, year = {2009}, abstract = {Recent evidence suggests that heterogeneity in the age at onset could explain the inconsistent findings of association studies relating the dopamine transporter (DAT1) gene with alcohol and nicotine consumption. The aim of this study was to examine interactions between two DAT1 polymorphisms and different initiation ages with regard to alcohol and tobacco consumption levels and dependence. Two hundred and ninety-one young adults (135 males, 156 females) participating in the Mannheim Study of Children at Risk were genotyped for the 40-bp variable number of tandem repeats (VNTR) and rs27072 polymorphisms of DAT1. Age at initiation was assessed at age 15 and 19 years. Information about current alcohol and tobacco consumption was obtained at age 19 years using self-report measures and structured interviews. Results suggest that age at onset of intensive consumption moderated the association of the DAT1 gene with early adult substance use and dependence, revealing a DAT1 effect only among individuals homozygous for the 10r allele of the 40-bp VNTR who had started daily smoking or being intoxicated early in life. Equally, carriers of the T allele of the rs27072 polymorphism reporting an early age at first intoxication showed higher current alcohol consumption at age 19 years. In contrast, no interaction between rs27072 and the age at first cigarette with regard to later smoking was observed. These findings provide evidence that the DAT1 gene interacts with an early heavy or regular drug exposure of the maturing adolescent brain to predict substance (ab)use in young adulthood. Further studies are required to confirm these findings.}, language = {en} } @article{BuchmannKopfWestphaletal.2010, author = {Buchmann, Arlette F. and Kopf, Daniel and Westphal, Sabine and Lederbogen, Florian and Banaschewski, Tobias and Esser, G{\"u}nter and Schmidt, Martin H. and Zimmermann, Ulrich S. and Laucht, Manfred and Deuschle, Michael}, title = {Impact of early parental child-rearing behavior on young adults' cardiometabolic risk profile : a prospective study}, issn = {0033-3174}, doi = {10.1097/Psy.0b013e3181c88343}, year = {2010}, abstract = {Objective: To examine prospectively whether early parental child-rearing behavior is a predictor of cardiometabolic outcome in young adulthood when other potential risk factors are controlled. Metabolic factors associated with increased risk for cardiovascular disease have been found to vary, depending on lifestyle as well as genetic predisposition. Moreover, there is evidence suggesting that environmental conditions, such as stress in pre- and postnatal life, may have a sustained impact on an individual's metabolic risk profile. Methods: Participants were drawn from a prospective, epidemiological, cohort study followed up from birth into young adulthood. Parent interviews and behavioral observations at the age of 3 months were conducted to assess child-rearing practices and mother-infant interaction in the home setting and in the laboratory. In 279 participants, anthropometric characteristics, low-density lipoprotein and high-density lipoprotein cholesterol, apolipoproteins, and triglycerides were recorded at age 19 years. In addition, structured interviews were administered to the young adults to assess indicators of current lifestyle and education. Results: Adverse early-life interaction experiences were significantly associated with lower levels of high- density lipoprotein cholesterol and apolipoprotein A1 in young adulthood. Current lifestyle variables and level of education did not account for this effect, although habitual smoking and alcohol consumption also contributed significantly to cardiometabolic outcomes. Conclusions: These findings suggest that early parental child-rearing behavior may predict health outcome in later life through its impact on metabolic parameters in adulthood.}, language = {en} } @article{BuchmannSchmidBlomeyeretal.2010, author = {Buchmann, Arlette F. and Schmid, Brigitte and Blomeyer, Dorothea and Zimmermann, Ulrich S. and Jennen-Steinmetz, Christine and Schmidt, Martin H. and Esser, G{\"u}nter and Banaschewski, Tobias and Mann, Karl F. and Laucht, Manfred}, title = {Drinking against unpleasant emotions : possible outcome of early onset of alcohol use?}, issn = {0145-6008}, doi = {10.1111/j.1530-0277.2010.01180.x}, year = {2010}, abstract = {Background: Recent animal and human studies indicate that the exposure to alcohol during early adolescence increases the risk for heavy alcohol use in response to stress. The purpose of this study was to examine whether this effect may be the consequence of a higher susceptibility to develop "drinking to cope" motives among early initiators. Methods: Data from 320 participants were collected as part of the Mannheim Study of Children at Risk, an ongoing epidemiological cohort study. Structured interviews at age 15 and 19 were used to assess age at first alcohol experience and drunkenness. The young adults completed questionnaires to obtain information about the occurrence of stressful life events during the past 4 years and current drinking habits. In addition, alcohol use under conditions of negative states was assessed with the Inventory of Drinking Situations. Results: The probability of young adults' alcohol use in situations characterized by unpleasant emotions was significantly increased the earlier they had initiated the use of alcohol, even when controlling for current drinking habits and stressful life events. Similar results were obtained for the age at first drunkenness. Conclusions: The findings strengthen the hypothesis that alcohol experiences during early adolescence facilitate drinking to regulate negative affect as an adverse coping strategy which may represent the starting point of a vicious circle comprising drinking to relieve stress and increased stress as a consequence of drinking.}, language = {en} } @article{SchmidBuchmannTrautmannVillalbaetal.2013, author = {Schmid, Brigitte and Buchmann, Arlette F. and Trautmann-Villalba, Patricia and Blomeyer, Dorothea and Zimmermann, Ulrich S. and Schmidt, Martin H. and Esser, G{\"u}nter and Banaschewski, Tobias and Laucht, Manfred}, title = {Maternal stimulation in infancy predicts hypothalamic-pituitary-adrenal axis reactivity in young men}, series = {Journal of neural transmission}, volume = {120}, journal = {Journal of neural transmission}, number = {8}, publisher = {Springer}, address = {Wien}, issn = {0300-9564}, doi = {10.1007/s00702-013-0970-8}, pages = {1247 -- 1257}, year = {2013}, abstract = {Evidence from animal research has demonstrated the effect of early maternal care on the offspring's endocrine and behavioral stress response in adulthood. The present prospective study investigates, in humans, the long-term impact of maternal responsiveness and stimulation during early mother-child interaction on adrenocorticotropic hormone (ACTH) and cortisol response to a psychosocial laboratory stressor in adulthood. The data are from an epidemiological cohort study of the long-term outcome of early risk factors assessed at birth. At age 3 months, mothers and infants were videotaped during a 10-min standardized nursing and playing situation and evaluated by trained raters for maternal stimulation and infant and maternal responsiveness. At age 19 years, 270 participants (146 females, 124 males) completed the Trier Social Stress Test. The results indicated that less maternal stimulation during early interaction at age 3 months predicted diminished plasma ACTH and cortisol increase in response to acute psychosocial stress in male, but not female offspring. In contrast, maternal responsiveness was found to be unrelated to hypothalamic-pituitary-adrenal (HPA) reactivity. In accordance with the findings from animal research, the present study provides prospective evidence in humans of a long-term association between early maternal interaction behavior and the offspring's hormonal stress response in young adulthood, suggesting that poor maternal stimulation in early infancy may result in reduced HPA axis reactivity to an acute psychosocial stressor in males.}, language = {en} } @article{BuchmannHellwegRietscheletal.2013, author = {Buchmann, Arlette F. and Hellweg, Rainer and Rietschel, Marcella and Treutlein, Jens and Witt, Stephanie H. and Zimmermann, Ulrich S. and Schmidt, Martin H. and Esser, G{\"u}nter and Banaschewski, Tobias and Laucht, Manfred and Deuschle, Michael}, title = {BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brain-derived neurotrophic factor and depressive symptoms - a prospective study}, series = {European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology}, volume = {23}, journal = {European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology}, number = {8}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0924-977X}, doi = {10.1016/j.euroneuro.2012.09.003}, pages = {902 -- 909}, year = {2013}, abstract = {Recent studies have emphasized an important role for neurotrophins, such as brain-derived neurotrophic factor (BDNF), in regulating the plasticity of neural circuits involved in the pathophysiology of stress-related diseases. The aim of the present study was to examine the interplay of the BDNF Val(66)Met and the serotonin transporter promoter (5-HTTLPR) polymorphisms in moderating the impact of early-life adversity on BDNF plasma concentration and depressive symptoms. Participants were taken from an epidemiological cohort study following the long-term outcome of early risk factors from birth into young adulthood. In 259 individuals (119 males, 140 females), genotyped for the BDNF Val(66)Met and the 5-HTTLPR polymorphisms, plasma BDNF was assessed at the age of 19 years. In addition, participants completed the Beck Depression Inventory (BDI). Early adversity was determined according to a family adversity index assessed at 3 months of age. Results indicated that individuals homozygous for both the BDNF Val and the 5-HTTLPR L allele showed significantly reduced BDNF levels following exposure to high adversity. In contrast, BDNF levels appeared to be unaffected by early psychosocial adversity in carriers of the BDNF Met or the 5-HTTLPR S allele. While the former group appeared to be most susceptible to depressive symptoms, the impact of early adversity was less pronounced in the latter group. This is the first preliminary evidence indicating that early-life adverse experiences may have lasting sequelae for plasma BDNF levels in humans, highlighting that the susceptibility to this effect is moderated by BDNF Val(66)Met and 5-HTTLPR genotype.}, language = {en} } @article{LauchtBlomeyerBuchmannetal.2012, author = {Laucht, Manfred and Blomeyer, Dorothea and Buchmann, Arlette F. and Treutlein, Jens and Schmidt, Martin H. and Esser, G{\"u}nter and Jennen-Steinmetz, Christine and Rietschel, Marcella and Zimmermann, Ulrich S. and Banaschewski, Tobias}, title = {Catechol-O-methyltransferase Val158Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis}, series = {The journal of child psychology and psychiatry}, volume = {53}, journal = {The journal of child psychology and psychiatry}, number = {4}, publisher = {Wiley-Blackwell}, address = {Malden}, issn = {0021-9630}, doi = {10.1111/j.1469-7610.2011.02408.x}, pages = {351 -- 359}, year = {2012}, abstract = {Background: Recently, first evidence has been reported for a geneparenting interaction (G x E) with regard to adolescent alcohol use. The present investigation set out to extend this research using the catechol-O-methyltransferase (COMT) Val158Met polymorphism as a genetic susceptibility factor. Moreover, the current study examined whether a potential G x E would be consistent with one of two models of geneenvironment interplay (genetic vulnerability vs. differential susceptibility). Methods: Data were collected as part of an ongoing epidemiological cohort study following the outcome of early risk factors from birth into adulthood. Two hundred and eighty-five participants (130 males, 155 females) were genotyped for the COMT Val(158) Met polymorphism and were administered an alcohol interview, providing measures of current frequency and amount of drinking at ages 15 and 19 years. Information on three dimensions of perceived parenting behavior was obtained from the 15-year-olds. Results: Adolescents homozygous for the Met allele showed higher drinking activity at age 19 years when their parents had engaged in less supervision or were less involved, while their drinking activity was reduced under conditions of favorable parenting. No such relationship was found in individuals carrying the Val allele. Conclusions: The present findings correspond with the pattern of results predicted by the differential susceptibility hypothesis, suggesting that environmental variation would have a greater impact in individuals carrying a genetic susceptibility such that, in this group, exposure to negative environmental conditions would result in more adverse outcomes and the experience of favorable conditions would lead to more positive outcomes.}, language = {en} } @article{WittBuchmannBlomeyeretal.2011, author = {Witt, Stephanie H. and Buchmann, Arlette F. and Blomeyer, Dorothea and Nieratschker, Vanessa and Treutlein, Jens and Esser, G{\"u}nter and Schmidt, Martin H. and Bidlingmaier, Martin and Wiedemann, Klaus and Rietschel, Marcella and Laucht, Manfred and Wuest, Stefan and Zimmermann, Ulrich S.}, title = {An interaction between a neuropeptide Y gene polymorphism and early adversity modulates endocrine stress responses}, series = {Psychoneuroendocrinology}, volume = {36}, journal = {Psychoneuroendocrinology}, number = {7}, publisher = {Elsevier}, address = {Oxford}, issn = {0306-4530}, doi = {10.1016/j.psyneuen.2010.12.015}, pages = {1010 -- 1020}, year = {2011}, abstract = {Interindividual variability in the regulation of the human stress system accounts for a part of the individual's liability to stress-related diseases. These differences are influenced by environmental and genetic factors. Early childhood adversity is a well-studied environmental factor affecting an individual's stress response which has been shown to be modulated by gene environment interaction (GxE). Neuropeptide Y (NPY) plays a role in stress regulation and genetic variation in NPY may influence stress responses. In this study, we analyzed the association of a common variant in the NPY gene promoter, rs16147, with cortisol and ACTH responses to acute psychosocial stress in young adults from the Mannheim Study of Children at Risk (MARS), an ongoing epidemiological cohort study following the outcome of early adversity from birth into adulthood. We found evidence of a GxE interaction between rs16147 and early adversity significantly affecting HPA axis responses to acute psychosocial stress. These findings suggest that the neurobiological mechanisms linking early adverse experience and later neuroendocrine stress regulation are modulated by a gene variant whose functional relevance is documented by increasing convergent evidence from in vitro, animal and human studies.}, language = {en} } @article{GruberChakravartyBaehtzetal.2011, author = {Gruber, W. and Chakravarty, S. and Baehtz, C. and Leitenberger, Wolfram and Bruns, M. and Kobler, A. and K{\"u}bel, Christian and Schmidt, H.}, title = {Strain relaxation and vacancy creation in thin platinum films}, series = {Physical review letters}, volume = {107}, journal = {Physical review letters}, number = {26}, publisher = {American Physical Society}, address = {College Park}, issn = {0031-9007}, doi = {10.1103/PhysRevLett.107.265501}, pages = {5}, year = {2011}, abstract = {Synchrotron based combined in situ x-ray diffractometry and reflectometry is used to investigate the role of vacancies for the relaxation of residual stress in thin metallic Pt films. From the experimentally determined relative changes of the lattice parameter a and of the film thickness L the modification of vacancy concentration and residual strain was derived as a function of annealing time at 130 degrees C. The results indicate that relaxation of strain resulting from compressive stress is accompanied by the creation of vacancies at the free film surface. This proves experimentally the postulated dominant role of vacancies for stress relaxation in thin metal films close to room temperature.}, language = {en} } @article{UhligMadaboosiSchmidtetal.2012, author = {Uhlig, Katja and Madaboosi, Narayanan and Schmidt, Stephan and J{\"a}ger, Magnus S. and Rose, J{\"u}rgen and Duschl, Claus and Volodkin, Dmitry V.}, title = {3d localization and diffusion of proteins in polyelectrolyte multilayers}, series = {Soft matter}, volume = {8}, journal = {Soft matter}, number = {47}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1744-683X}, doi = {10.1039/c2sm26500a}, pages = {11786 -- 11789}, year = {2012}, abstract = {The interaction of diverse biomaterials with surfaces is more crucial than ever for biomedical applications to ensure efficiency and reproducibility. Very interesting surface materials are micrometer-thick polyelectrolyte multilayers. Not only their surface but also the bulk can be loaded with biomaterials like proteins or DNA for various purposes. Therefore, we established a method to analyze the lateral and vertical distribution of fluorescently labelled proteins of various size and charge in polyelectrolyte films composed of poly(L-lysine) and hyaluronic acid by confocal laser scanning microscopy. This approach enables us to measure the diffusion coefficients of the proteins via fluorescence recovery after photobleaching as a function of their vertical position in the film and facilitates the understanding of molecular interactions in the film with a high resolution in both space and time. As a result, we confirm that protein loading in the film is driven by electrostatic interactions - uncharged dextran molecules of 10 and 500 kDa do not diffuse into the film. Proteins of different sizes (3-11 nm) can diffuse relatively fast (D = 2-4 mm(2) s(-1)) independent of their net charge, indicating complex interpolymer interactions. This approach is a new powerful experimental tool to design the polyelectrolyte multilayers for bio-applications by finding a relationship between intermolecular interactions and mobility and availability of biomolecules to biological samples (e.g. cells) or detection units (e.g. biosensors).}, language = {en} } @article{BuchmannHolzBoeckerSchlieretal.2014, author = {Buchmann, Arlette F. and Holz, Nathalie and Boecker-Schlier, Regina and Blomeyer, Dorothea and Rietschel, Marcella and Witt, Stephanie H. and Schmidt, Martin H. and Esser, G{\"u}nter and Banaschewski, Tobias and Brandeis, Daniel and Zimmermann, Ulrich S. and Laucht, Manfred}, title = {Moderating role of FKBP5 genotype in the impact of childhood adversity on cortisol stress response during adulthood}, series = {European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology}, volume = {24}, journal = {European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology}, number = {6}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0924-977X}, doi = {10.1016/j.euroneuro.2013.12.001}, pages = {837 -- 845}, year = {2014}, abstract = {Recent research suggests an important role of FKBP5, a glucocorticoid receptor regulating co-chaperone, in the development of stress-related diseases such as depression and anxiety disorders. The present study aimed to replicate and extend previous evidence indicating that FKBP5 polymorphisms moderate hypothalamus-pituitary-adrenal (HPA) function by examining whether FKBP5 rs1360780 genotype and different measures of childhood adversity interact to predict stress-induced cortisol secretion. At age 19 years, 195 young adults (90 males, 105 females) participating in an epidemiological cohort study completed the Trier Social Stress Test (TSST) to assess cortisol stress responsiveness and were genotyped for the FKBP5 rs1360780. Childhood adversity was assessed using the Childhood Trauma Questionnaire (CTQ) and by a standardized parent interview yielding an index of family adversity. A significant interaction between genotype and childhood adversity on cortisol response to stress was demonstrated for exposure to childhood maltreatment as assessed by retrospective self-report (CTQ), but not for prospectively ascertained objective family adversity. Severity of childhood maltreatment was significantly associated with attenuated cortisol levels among carriers of the rs1360780 CC genotype, while no such effect emerged in carriers of the T allele. These findings point towards the functional involvement of FKBP5 in long-term alterations of neuroendocrine stress regulation related to childhood maltreatment, which have been suggested to represent a premorbid risk or resilience factor in the context of stress-related disorders. (C) 2013 Elsevier B.V. and ECNR This is an open access article under the CC BY-NC-ND license.}, language = {en} } @article{SchmidBlomeyerBuchmannetal.2011, author = {Schmid, Brigitte and Blomeyer, Dorothea and Buchmann, Arlette F. and Trautmann-Villalba, Patricia and Zimmermann, Ulrich S. and Schmidt, Martin H. and Esser, G{\"u}nter and Banaschewski, Tobias and Laucht, Manfred}, title = {Quality of early mother-child interaction associated with depressive psychopathology in the offspring - a prospective study from infancy to adulthood}, series = {Journal of psychiatric research}, volume = {45}, journal = {Journal of psychiatric research}, number = {10}, publisher = {Elsevier}, address = {Oxford}, issn = {0022-3956}, doi = {10.1016/j.jpsychires.2011.05.010}, pages = {1387 -- 1394}, year = {2011}, abstract = {Evidence from animal research has revealed that less maternal care results in disturbed emotionality in the offspring. In the present study, the long-term impact of maternal responsiveness and stimulation during early mother child interaction on depressive psychopathology was examined until adulthood. Data are from an epidemiological cohort study of the long-term outcome of early risk factors assessed at birth. At age 3 months, mothers and infants were videotaped during a nursing and playing situation. Maternal responsiveness and stimulation as well as infant responsiveness were evaluated by trained raters. At age 19 years, 314 participants (145 males, 169 females) were characterized on measures of depression through interview and questionnaire. In addition, measures of depression and anxiety were available from assessments in childhood. Results indicated that less maternal stimulation during early interaction was associated with a higher risk of depression in the offspring until the age of 19 years. In addition, children of less stimulating mothers showed more depressive symptoms at age 19 years and displayed more anxiety and depressive symptoms between the ages of 4.5 and 15 years. In contrast, maternal responsiveness was unrelated to children's outcome. In accordance with findings from animal research, the present study provides first longitudinal evidence in humans of a continuous and long-term influence of early maternal interaction behavior on the offspring's psychological adjustment until adulthood. The results suggest that the amount of maternally initiated contact behavior in a very early developmental stage may be crucial for children's mental health, regardless of child and maternal responsiveness.}, language = {en} }