@article{PanMaLiuetal.2021,
  author    = {Pan, Yuanwei and Ma, Xuehua and Liu, Chuang and Xing, Jie and Zhou, Suqiong and Parshad, Badri and Schwerdtle, Tanja and Li, Wenzhong and Wu, Aiguo and Haag, Rainer},
  title     = {Retinoic acid-loaded dendritic polyglycerol-conjugated gold nanostars for targeted photothermal therapy in breast cancer stem cells},
  series = {ACS nano},
  volume    = {15},
  journal   = {ACS nano},
  number    = {9},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {1936-0851},
  doi       = {10.1021/acsnano.1c05452},
  pages     = {15069 -- 15084},
  year      = {2021},
  abstract  = {The existence of cancer stem cells (CSCs) poses a major obstacle for the success of current cancer therapies, especially the fact that non-CSCs can spontaneously turn into CSCs, which lead to the failure of the treatment and tumor relapse. Therefore, it is very important to develop effective strategies for the eradication of the CSCs. In this work, we have developed a CSCs-specific targeted, retinoic acid (RA)-loaded gold nanostars-dendritic polyglycerol (GNSs-dPG) nanoplatform for the efficient eradication of CSCs. The nanocomposites possess good biocompatibility and exhibit effective CSCs-specific multivalent targeted capability due to hyaluronic acid (HA) decorated on the multiple attachment sites of the bioinert dendritic polyglycerol (dPG). With the help of CSCs differentiation induced by RA, the self-renewal of breast CSCs and tumor growth were suppressed by the high therapeutic efficacy of photothermal therapy (PTT) in a synergistic inhibitory manner. Moreover, the stemness gene expression and CSC-driven tumorsphere formation were significantly diminished. In addition, the in vivo tumor growth and CSCs were also effectively eliminated, which indicated superior anticancer activity, effective CSCs suppression, and prevention of relapse. Taken together, we developed a CSCs-specific targeted, RA-loaded GNSs-dPG nanoplatform for the targeted eradication of CSCs and for preventing the relapse.},
  language  = {en}
}
@article{LiSchlaichZhangetal.2021,
  author    = {Li, Mingjun and Schlaich, Christoph and Zhang, Jianguang and Donskyi, Ievgen and Schwibbert, Karin and Schreiber, Frank and Xia, Yi and Radnik, J{\"o}rg and Schwerdtle, Tanja and Haag, Rainer},
  title     = {Mussel-inspired multifunctional coating for bacterial infection prevention and osteogenic induction},
  series = {Journal of materials science \& technology : JMST ; an international journal / spons. by the Chinese Society for Metals (CSM), the Chinese Materials Research Society (CMRS), Institute of Metal Research, Chinese Academy of Sciences},
  volume    = {68},
  journal   = {Journal of materials science \& technology : JMST ; an international journal / spons. by the Chinese Society for Metals (CSM), the Chinese Materials Research Society (CMRS), Institute of Metal Research, Chinese Academy of Sciences},
  publisher = {Elsevier},
  address   = {Amsterdam [u.a.]},
  issn      = {1005-0302},
  doi       = {10.1016/j.jmst.2020.08.011},
  pages     = {160 -- 171},
  year      = {2021},
  abstract  = {Bacterial infection and osteogenic integration are the two main problems that cause severe complications after surgeries. In this study, the antibacterial and osteogenic properties were simultaneously introduced in biomaterials, where copper nanoparticles (CuNPs) were generated by in situ reductions of Cu ions into a mussel-inspired hyperbranched polyglycerol (MI-hPG) coating via a simple dip-coating method. This hyperbranched polyglycerol with 10 \% catechol groups' modification presents excellent antifouling property, which could effectively reduce bacteria adhesion on the surface. In this work, polycaprolactone (PCL) electrospun fiber membrane was selected as the substrate, which is commonly used in biomedical implants in bone regeneration and cardiovascular stents because of its good biocompatibility and easy post-modification. The as-fabricated CuNPs-incorporated PCL membrane [PCL-(MI-hPG)-CuNPs] was confirmed with effective antibacterial performance via in vitro antibacterial tests against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and multi-resistant E. coli. In addition, the in vitro results demonstrated that osteogenic property of PCL-(MI-hPG)-CuNPs was realized by upregulating the osteoblast-related gene expressions and protein activity. This study shows that antibacterial and osteogenic properties can be balanced in a surface coating by introducing CuNPs.},
  language  = {en}
}