@article{MelcherHartmannZopfetal.2011,
  author    = {Melcher, Ralph and Hartmann, Elena and Zopf, Waltraud and Herterich, Sabine and Wilke, Philipp and Mueller, Ludwig and Rosler, Eduard and Kudlich, Theodor and Al-Taie, Oliver and Rosenwald, Andreas and Katzenberger, Tiemo and Scholtka, Bettina and Seibold, Stefan and Rogoll, Dorothee and Scheppach, Wolfgang and Scheurlen, Michael and Luehrs, Hardi},
  title     = {LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability},
  series = {Carcinogenesis : a comprehensive survey},
  volume    = {32},
  journal   = {Carcinogenesis : a comprehensive survey},
  number    = {4},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {0143-3334},
  doi       = {10.1093/carcin/bgr011},
  pages     = {636 -- 642},
  year      = {2011},
  abstract  = {Background and aims. Tumor suppressor genes are often located in frequently deleted chromosomal regions of colorectal cancers (CRCs). In contrast to microsatellite stable (MSS) tumors, only few loss of heterozygosity (LOH) studies were performed in microsatellite instable (MSI) tumors, because MSI carcinomas are generally considered to be chromosomally stable and classical LOH studies are not feasible due to MSI. The single nucleotide polymorphism (SNP) array technique enables LOH studies also in MSI CRC. The aim of our study was to analyse tissue from MSI and MSS CRC for the existence of (frequently) deleted chromosomal regions and tumor suppressor genes located therein. Methods and results. We analyzed tissues from 32 sporadic CRCs and their corresponding normal mucosa (16 MSS and 16 MSI tumors) by means of 50K SNP array analysis. MSS tumors displayed chromosomal instability that resulted in multiple deleted (LOH) and amplified regions and led to the identification of MTUS1 (8p22) as a candidate tumor suppressor gene in this region. Although the MSI tumors were chromosomally stable, we found several copy neutral LOHs (cnLOH) in the MSI tumors; these appear to be instrumental in the inactivation of the tumor suppressor gene hMLH1 and a gene located in chromosomal region 6pter-p22. Discussion. Our results suggest that in addition to classical LOH, cnLOH is an important mutational event in relation to the carcinogenesis of MSS and MSI tumors, causing the inactivation of a tumor suppressor gene without copy number alteration of the respective region; this is crucial for the development of MSI tumors and for some chromosomal regions in MSS tumors.},
  language  = {en}
}
@article{BartelHartmannLehmannetal.2012,
  author    = {Bartel, Manuela and Hartmann, Stefanie and Lehmann, Karola and Postel, Kai and Quesada, Humberto and Philipp, Eva E. R. and Heilmann, Katja and Micheel, Burkhard and Stuckas, Heiko},
  title     = {Identification of sperm proteins as candidate biomarkers for the analysis of reproductive isolation in Mytilus: a case study for the enkurin locus},
  series = {Marine biology : international journal on life in oceans and coastal waters},
  volume    = {159},
  journal   = {Marine biology : international journal on life in oceans and coastal waters},
  number    = {10},
  publisher = {Springer},
  address   = {New York},
  issn      = {0025-3162},
  doi       = {10.1007/s00227-012-2005-7},
  pages     = {2195 -- 2207},
  year      = {2012},
  abstract  = {Sperm proteins of the marine sessile mussels of the Mytilus edulis species complex are models to investigate reproductive isolation and speciation. This study aimed at identifying sperm proteins and their corresponding genes. This was aided by the use of monoclonal antibodies that preferentially bind to yet unknown sperm molecules. By identifying their target molecules, this approach identified proteins with relevance to Mytilus sperm function. This procedure identified 16 proteins, for example, enkurin, laminin, porin and heat shock proteins. The potential use of these proteins as genetic markers to study reproductive isolation is exemplified by analysing the enkurin locus. Enkurin evolution is driven by purifying selection, the locus displays high levels of intraspecific variation and species-specific alleles group in distinct phylogenetic clusters. These findings characterize enkurin as informative candidate biomarker for analyses of clinal variation and differential introgression in hybrid zones, for example, to understand determinants of reproductive isolation in Baltic Mytilus populations.},
  language  = {en}
}
@book{Hartmann1997,
  author    = {Hartmann, Philipp},
  title     = {Foreign exchange vehicles before and after EMU : from Dollar/Mark to Dollar/Euro?},
  series = {Diskussionsbeitrag / Europ{\"a}isches Institut f{\"u}r Internationale Wirtschaftsbeziehungen},
  volume    = {24},
  journal   = {Diskussionsbeitrag / Europ{\"a}isches Institut f{\"u}r Internationale Wirtschaftsbeziehungen},
  publisher = {Univ. Potsdam},
  address   = {Potsdam},
  issn      = {1430-5445},
  pages     = {21 S. : graph. Darst.},
  year      = {1997},
  language  = {en}
}
@article{RamischLockotHaberzettletal.2016,
  author    = {Ramisch, Arne and Lockot, Gregori and Haberzettl, Torsten and Hartmann, Kai and Kuhn, Gerhard and Lehmkuhl, Frank and Schimpf, Stefan and Schulte, Philipp and Stauch, Georg and Wang, Rong and Wunnemann, Bernd and Yan, Dada and Zhang, Yongzhan and Diekmann, Bernhard},
  title     = {A persistent northern boundary of Indian Summer Monsoon precipitation over Central Asia during the Holocene},
  series = {Scientific reports},
  volume    = {6},
  journal   = {Scientific reports},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/srep25791},
  pages     = {596 -- 633},
  year      = {2016},
  abstract  = {Extra-tropical circulation systems impede poleward moisture advection by the Indian Summer Monsoon. In this context, the Himalayan range is believed to insulate the south Asian circulation from extra-tropical influences and to delineate the northern extent of the Indian Summer Monsoon in central Asia. Paleoclimatic evidence, however, suggests increased moisture availability in the Early Holocene north of the Himalayan range which is attributed to an intensification of the Indian Summer Monsoon. Nevertheless, mechanisms leading to a surpassing of the Himalayan range and the northern maximum extent of summer monsoonal influence remain unknown. Here we show that the Kunlun barrier on the northern Tibetan Plateau [similar to 36 degrees N] delimits Indian Summer Monsoon precipitation during the Holocene. The presence of the barrier relocates the insulation effect 1,000 km further north, allowing a continental low intensity branch of the Indian Summer Monsoon which is persistent throughout the Holocene. Precipitation intensities at its northern extent seem to be driven by differentiated solar heating of the Northern Hemisphere indicating dependency on energy-gradients rather than absolute radiation intensities. The identified spatial constraints of monsoonal precipitation will facilitate the prediction of future monsoonal precipitation patterns in Central Asia under varying climatic conditions.},
  language  = {en}
}