@article{EhmannZollerMinichmayretal.2017,
  author    = {Ehmann, Lisa and Zoller, Michael and Minichmayr, Iris K. and Scharf, Christina and Maier, Barbara and Schmitt, Maximilian V. and Hartung, Niklas and Huisinga, Wilhelm and Vogeser, Michael and Frey, Lorenz and Zander, Johannes and Kloft, Charlotte},
  title     = {Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients},
  series = {Critical care},
  volume    = {21},
  journal   = {Critical care},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1466-609X},
  doi       = {10.1186/s13054-017-1829-4},
  pages     = {14},
  year      = {2017},
  abstract  = {Background: Severe bacterial infections remain a major challenge in intensive care units because of their high prevalence and mortality. Adequate antibiotic exposure has been associated with clinical success in critically ill patients. The objective of this study was to investigate the target attainment of standard meropenem dosing in a heterogeneous critically ill population, to quantify the impact of the full renal function spectrum on meropenem exposure and target attainment, and ultimately to translate the findings into a tool for practical application. Methods: A prospective observational single-centre study was performed with critically ill patients with severe infections receiving standard dosing of meropenem. Serial blood samples were drawn over 4 study days to determine meropenem serum concentrations. Renal function was assessed by creatinine clearance according to the Cockcroft and Gault equation (CLCRCG). Variability in meropenem serum concentrations was quantified at the middle and end of each monitored dosing interval. The attainment of two pharmacokinetic/pharmacodynamic targets (100\% T->MIC, 50\% T->4xMIC) was evaluated for minimum inhibitory concentration (MIC) values of 2 mg/L and 8 mg/L and standard meropenem dosing (1000 mg, 30-minute infusion, every 8 h). Furthermore, we assessed the impact of CLCRCG on meropenem concentrations and target attainment and developed a tool for risk assessment of target non-attainment. Results: Large inter-and intra-patient variability in meropenem concentrations was observed in the critically ill population (n = 48). Attainment of the target 100\% T->MIC was merely 48.4\% and 20.6\%, given MIC values of 2 mg/L and 8 mg/L, respectively, and similar for the target 50\% T->4xMIC. A hyperbolic relationship between CLCRCG (25-255 ml/minute) and meropenem serum concentrations at the end of the dosing interval (C-8h) was derived. For infections with pathogens of MIC 2 mg/L, mild renal impairment up to augmented renal function was identified as a risk factor for target non-attainment (for MIC 8 mg/L, additionally, moderate renal impairment). Conclusions: The investigated standard meropenem dosing regimen appeared to result in insufficient meropenem exposure in a considerable fraction of critically ill patients. An easy-and free-to-use tool (the MeroRisk Calculator) for assessing the risk of target non-attainment for a given renal function and MIC value was developed.},
  language  = {en}
}
@article{StinnesbeckBeckerHeringetal.2017,
  author    = {Stinnesbeck, Wolfgang and Becker, Julia and Hering, Fabio and Frey, Eberhard and Gonzalez Gonzalez, Arturo and Fohlmeister, Jens Bernd and Stinnesbeck, Sarah and Frank, Norbert and Terrazas Mata, Alejandro and Elena Benavente, Martha and Aviles Olguin, Jeronimo and Aceves Nunez, Eugenio and Zell, Patrick and Deininger, Michael},
  title     = {The earliest settlers of Mesoamerica date back to the late Pleistocene},
  series = {PLoS one},
  volume    = {12},
  journal   = {PLoS one},
  publisher = {PLoS},
  address   = {San Fransisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0183345},
  pages     = {20},
  year      = {2017},
  abstract  = {Preceramic human skeletal remains preserved in submerged caves near Tulum in the Mexican state of Quintana Roo, Mexico, reveal conflicting results regarding C-14 dating. Here we use U-series techniques for dating a stalagmite overgrowing the pelvis of a human skeleton discovered in the submerged Chan Hol cave. The oldest closed system U/Th age comes from around 21 mm above the pelvis defining the terminus ante quem for the pelvis to 11311 +/- 370 y BP. However, the skeleton might be considerable older, probably as old as 13 ky BP as indicated by the speleothem stable isotope data. The Chan Hol individual confirms a late Pleistocene settling of Mesoamerica and represents one of the oldest human osteological remains in America.},
  language  = {en}
}
@book{Frey2023,
  author    = {Frey, Michael},
  title     = {Grenz{\"u}berschreitende Daseinsvorsorge im deutsch-polnischen Grenzraum},
  series = {KWI-Diskurs},
  journal   = {KWI-Diskurs},
  number    = {2},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {2941-4830},
  doi       = {10.25932/publishup-59190},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-591904},
  publisher      = {Universit{\"a}t Potsdam},
  year      = {2023},
  abstract  = {Der Bereich der grenz{\"u}berschreitenden Daseinsvorsorge ist eines der zentralen Potentialfelder in der Grenz{\"u}berschreitenden Zusammenarbeit. Grenz{\"u}berschreitende Daseinsvorsorge kann ein wesentliches Element zur Verbesserung der Lebensverh{\"a}ltnisse in Grenzregionen sein. Bei der Umsetzung von Projekten im diesem Bereich sind - sofern der politische Wille hierf{\"u}r vorhanden ist - erhebliche rechtliche H{\"u}rden zu {\"u}berwinden: Zwar existieren passend ausgerichtete europ{\"a}ische F{\"o}rdermittelprogramme als Anreiz, andererseits scheinen die europarechtlichen und nationalrechtlichen Rahmenbedingungen vielfach hochgradig komplex und k{\"o}nnen auch mit europarechtlichen Instrumenten, etwa dem Europ{\"a}ischen Verbund f{\"u}r territoriale Zusammenarbeit (EVTZ), kaum {\"u}berwunden werden. Der vorliegende Text analysiert am Beispiel der deutsch-polnischen die rechtlichen Schwierigkeiten, aber auch die M{\"o}glichkeiten zur Umsetzung grenz{\"u}berschreitender Projekte in diesem Bereich.},
  language  = {de}
}