@inproceedings{Rapp2015,
author = {Rapp, Michael A.},
title = {When Local Poverty is More Important Than Your Income: Migrant Mental Health in Inner Cities},
series = {European psychiatry : the journal of the Association of European Psychiatrists},
volume = {30},
booktitle = {European psychiatry : the journal of the Association of European Psychiatrists},
publisher = {Elsevier},
address = {Paris},
issn = {0924-9338},
pages = {1},
year = {2015},
language = {en}
}
@article{StroehleSchmidtSchultzetal.2015,
author = {Stroehle, Andreas and Schmidt, Dietlinde K. and Schultz, Florian and Fricke, Nina and Staden, Theresa and Hellweg, Rainer and Priller, Josef and Rapp, Michael A. and Rieckmann, Nina},
title = {Drug and Exercise Treatment of Alzheimer Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Effects on Cognition in Randomized Controlled Trials},
series = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
volume = {23},
journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
number = {12},
publisher = {Elsevier},
address = {New York},
issn = {1064-7481},
doi = {10.1016/j.jagp.2015.07.007},
pages = {1234 -- 1249},
year = {2015},
abstract = {Objective: Demographic changes are increasing the pressure to improve therapeutic strategies against cognitive decline in Alzheimer disease (AD) and mild cognitive impairment (MCI). Besides drug treatment, physical activity seems to be a promising intervention target as epidemiological and clinical studies suggest beneficial effects of exercise training on cognition. Using comparable inclusion and exclusion criteria, we analyzed the efficacy of drug therapy (cholinesterase inhibitors, memantine, and Ginkgo biloba) and exercise interventions for improving cognition in AD and MCI populations. Methods: We searched The Cochrane Library, EBSCO, OVID, Web of Science, and U.S Food and Drug Administration data from inception through October 30, 2013. Randomized controlled trials in which at least one treatment arm consisted of an exercise or a pharmacological intervention for AD or MCI patients, and which had either a non-exposed control condition or a control condition that received another intervention. Treatment discontinuation rates and Standardized Mean Change score using Raw score standardization (SMCR) of cognitive performance were calculated. Results: Discontinuation rates varied substantially and ranged between 0\% and 49\% with a median of 18\%. Significantly increased discontinuation rates were found for galantamine and rivastigmine as compared to placebo in AD studies. Drug treatments resulted in a small pooled effect on cognition (SMCR: 0.23, 95\% CI: 0.20 to 0.25) in AD studies (N = 45, 18,434 patients) and no effect in any of the MCI studies (N = 5, 3,693 patients; SMCR: 0.03, 95\% CI: 0.00 to 0.005). Exercise interventions had a moderate to strong pooled effect size (SMCR: 0.83, 95\% CI: 0.59 to 1.07) in AD studies (N = 4, 119 patients), and a small effect size (SMCR: 0.20, 95\% CI: 0.11 to 0.28) in MCI (N = 6, 443 patients). Conclusions: Drug treatments have a small but significant impact on cognitive functioning in AD and exercise has the potential to improve cognition in AD and MCI. Head-to-head trials with sufficient statistical power are necessary to directly compare efficacy, safety, and acceptability. Combining these two approaches might further increase the efficacy of each individual intervention. Identifier: PROSPERO (2013:CRD42013003910).},
language = {en}
}
@article{BohlkenWeberRappetal.2015,
author = {Bohlken, Jens and Weber, Simon and Rapp, Michael A. and Kostev, Karel},
title = {Continuous treatment with antidementia drugs in Germany 2003-2013: a retrospective database analysis},
series = {International psychogeriatrics},
volume = {27},
journal = {International psychogeriatrics},
number = {8},
publisher = {Cambridge Univ. Press},
address = {New York},
issn = {1041-6102},
doi = {10.1017/S1041610215000654},
pages = {1335 -- 1342},
year = {2015},
abstract = {Background: Continuous treatment is an important indicator of medication adherence in dementia. However, long-term studies in larger clinical settings are lacking, and little is known about moderating effects of patient and service characteristics. Methods: Data from 12,910 outpatients with dementia (mean age 79.2 years; SD = 7.6 years) treated between January 2003 and December 2013 in Germany were included. Continuous treatment was analysed using Kaplan-Meier curves and log-rank tests. In addition, multivariate Cox regression models were fitted with continuous treatment as dependent variable and the predictors antidementia agent, age, gender, medical comorbidities, physician specialty, and health insurance status. Results: After one year of follow-up, nearly 60\% of patients continued drug treatment. Donezepil (HR: 0.88; 95\% CI: 0.82-0.95) and memantine (HR: 0.85; 0.79-0.91) patients were less likely to be discontinued treatment as compared to rivastigmine users. Patients were less likely to be discontinued if they were treated by specialist physicians as compared to general practitioners (HR: 0.44; 0.41-0.48). Younger male patients and patients who had private health insurance had a lower discontinuation risk. Regarding comorbidity, patients were more likely to be continuously treated with the index substance if a diagnosis of heart failure or hypertension had been diagnosed at baseline. Conclusions: Our results imply that besides type of antidementia agent, involvement of a specialist in the complex process of prescribing antidementia drugs can provide meaningful benefits to patients, in terms of more disease-specific and continuous treatment.},
language = {en}
}
@article{HeinzelRiemerSchulteetal.2014,
author = {Heinzel, Stephan and Riemer, Thomas G. and Schulte, Stefanie and Onken, Johanna and Heinz, Andreas and Rapp, Michael A.},
title = {Catechol-O-methyltransferase (COMT) genotype affects age-related changes in plasticity in working memory: a pilot study},
series = {BioMed research international},
journal = {BioMed research international},
publisher = {Hindawi Publishing Corp.},
address = {New York},
issn = {2314-6133},
doi = {10.1155/2014/414351},
pages = {7},
year = {2014},
abstract = {Objectives. Recent work suggests that a genetic variation associated with increased dopamine metabolism in the prefrontal cortex (catechol-O-methyltransferase Val158Met; COMT) amplifies age-related changes in working memory performance. Research on younger adults indicates that the influence of dopamine-related genetic polymorphisms on working memory performance increases when testing the cognitive limits through training. To date, this has not been studied in older adults. Method. Here we investigate the effect of COMT genotype on plasticity in working memory in a sample of 14 younger (aged 24-30 years) and 25 older (aged 60-75 years) healthy adults. Participants underwent adaptive training in the n-back working memory task over 12 sessions under increasing difficulty conditions. Results. Both younger and older adults exhibited sizeable behavioral plasticity through training (P < .001), which was larger in younger as compared to older adults (P < .001). Age-related differences were qualified by an interaction with COMT genotype (P < .001), and this interaction was due to decreased behavioral plasticity in older adults carrying the Val/Val genotype, while there was no effect of genotype in younger adults. Discussion. Our findings indicate that age-related changes in plasticity in working memory are critically affected by genetic variation in prefrontal dopamine metabolism.},
language = {en}
}
@article{LiuSchadKuschpeletal.2016,
author = {Liu, Shuyan and Schad, Daniel and Kuschpel, Maxim S. and Rapp, Michael A. and Heinz, Andreas},
title = {Music and Video Gaming during Breaks},
series = {PLoS one},
volume = {11},
journal = {PLoS one},
number = {3},
publisher = {Public Library of Science},
address = {Lawrence, Kan.},
issn = {1932-6203},
doi = {10.1371/JOURNAL.PONE.0150165},
pages = {1 -- 12},
year = {2016},
abstract = {Different systems for habitual versus goal-directed control are thought to underlie human decision-making. Working memory is known to shape these decision-making systems and their interplay, and is known to support goal-directed decision making even under stress. Here, we investigated if and how decision systems are differentially influenced by breaks filled with diverse everyday life activities known to modulate working memory performance. We used a within-subject design where young adults listened to music and played a video game during breaks interleaved with trials of a sequential two-step Markov decision task, designed to assess habitual as well as goal-directed decision making. Based on a neurocomputational model of task performance, we observed that for individuals with a rather limited working memory capacity video gaming as compared to music reduced reliance on the goal-directed decision-making system, while a rather large working memory capacity prevented such a decline. Our findings suggest differential effects of everyday activities on key decision-making processes.},
language = {en}
}
@article{ZaytsevaKorsakovaGurovichetal.2014,
author = {Zaytseva, Yuliya and Korsakova, Natalya and Gurovich, Isaac Ya and Heinz, Andreas and Rapp, Michael A.},
title = {Luria revisited: Complex motor phenomena in first episode schizophrenia and schizophrenia spectrum disorders},
series = {Psychiatry research : the official publication of the International Society for Neuroimaging in Psychiatry},
volume = {220},
journal = {Psychiatry research : the official publication of the International Society for Neuroimaging in Psychiatry},
number = {1-2},
publisher = {Elsevier},
address = {Clare},
issn = {0165-1781},
doi = {10.1016/j.psychres.2014.08.009},
pages = {145 -- 151},
year = {2014},
language = {en}
}
@inproceedings{NordheimRappKrauseKoehleretal.2014,
author = {Nordheim, J. and Rapp, Michael A. and Krause-Koehler, Kathleen and Niemann-Mirmehdi, M. and Haeusler, Andreas},
title = {Support for dementia affected Couples. Results of the DYADEM- study},
series = {Zeitschrift f{\"u}r Gerontologie und Geriatrie},
volume = {47},
booktitle = {Zeitschrift f{\"u}r Gerontologie und Geriatrie},
publisher = {Springer},
address = {Heidelberg},
issn = {0948-6704},
pages = {136 -- 136},
year = {2014},
language = {de}
}
@misc{HeisselZechRappetal.2019,
author = {Heissel, Andreas and Zech, Philipp and Rapp, Michael A. and Schuch, Felipe B. and Lawrence, Jimmy B. and Kangas, Maria and Heinzel, Stephan},
title = {Effects of exercise on depression and anxiety in persons living with HIV: A meta-analysis},
series = {Journal of psychosomatic research},
volume = {126},
journal = {Journal of psychosomatic research},
publisher = {Elsevier},
address = {Oxford},
issn = {0022-3999},
doi = {10.1016/j.jpsychores.2019.109823},
pages = {12},
year = {2019},
abstract = {Objective: The purpose of this systematic review and meta-analysis was to examine the effects of exercise on depression and anxiety in people living with HIV (PLWH), and to evaluate, through subgroup analysis, the effects of exercise type, frequency, supervision by exercise professionals, study quality, and control group conditions on these outcomes. Method: A literature search was conducted through four electronic databases from inception to February 2019. Considered for inclusion were randomized controlled trials (RCTs) investigating exercise interventions and depression or anxiety as outcomes in people living with HIV (>= 18 years of age). Ten studies were included (n = 479 participants, 49.67\% females at baseline), and the standardized mean difference (SMD) and heterogeneity were calculated using random-effect models. An additional pre-post meta-analysis was also conducted. Results: A large effect in favor of exercise when compared to controls was found for depression (SMD = -0.84, 95\%CI = [-1.57, -0.11], p = 0.02) and anxiety (SMD = -1.23, 95\%CI = [-2.42, 0.04], p = -0.04). Subgroup analyses for depression revealed large effects on depression for aerobic exercise only (SMD = -0.96, 95\%CI = [-1.63, -0.30], p = 0.004), a frequency of >= 3 exercise sessions per week (SMD = -1.39, 95\%CI = [-2.24, -0.54], p < 0.001), professionally supervised exercise (SMD = -1.40, 95\%CI = [-2.46, -0.17], p = 0.03]), and high-quality studies (SMD = -1.31, 95\%CI = [-2.46, -0.17], p = 0.02). Conclusion: Exercise seems to decrease depressive symptoms and anxiety in PLWH, but other larger and high-quality studies are needed to verify these effects.},
language = {en}
}
@article{MellJacobFuhretal.2017,
author = {Mell, Thomas and Jacob, Louis and Fuhr, Ida and Dick, Sandra and Rapp, Michael A. and Kostev, Karel},
title = {Patterns of benzodiazepine prescribing by neuropsychiatrists and general practitioners for elderly patients in Germany in 2014},
series = {International journal of clinical pharmacology and therapeutics},
volume = {55},
journal = {International journal of clinical pharmacology and therapeutics},
publisher = {Dustri-Verlag Dr. Karl Feistle},
address = {Deisenhofen-M{\"u}nchen},
issn = {0946-1965},
doi = {10.5414/CP202904},
pages = {466 -- 471},
year = {2017},
abstract = {Background: The patterns of benzodiazepine prescriptions in older adults are of general and scientific interest as they are not yet well understood. The aim of this study was to compare the prescription patterns of benzodiazepines in elderly people in Germany to determine the share or proportion treated by general practitioners (GP) and neuropsychiatrists (NP). Methods: This study included 31,268 and 6,603 patients between the ages of 65 and 100 with at least one benzodiazepine prescription in 2014 from GP and NP, respectively. Demographic data included age, gender, and type of health insurance coverage. The share of elderly people with benzodiazepine prescriptions was estimated in different age and disease groups for both GP and NP patients. The share of the six most commonly prescribed drugs was also calculated for each type of practice. Results: The share of people taking benzodiazepines prescribed by GP increased from 3.2\% in patients aged between 65 and 69 years to 8.6\% in patients aged between 90 and 100 years, whereas this share increased from 5.4\% to 7.1\% in those seen by NP. Benzodiazepines were frequently used by patients suffering from sleep disorders (GP: 33.9\%; NP: 5.5\%), depression (GP: 17.9\%; NP: 29.8\%), and anxiety disorders (GP: 14.5\%; NP: 22.8\%). Lorazepam (30.3\%), oxazepam (24.7\%), and bromazepam (24.3\%) were the three most commonly prescribed drugs for GP patients. In contrast, lorazepam (60.4\%), diazepam (14.8\%), and oxazepam (11.2\%) were those more frequently prescribed to NP patients. Conclusion: Prescription patterns of benzodiazepine in the elderly varied widely between GP and NP.},
language = {en}
}
@article{ZechSchuchPerezChaparroetal.2020,
author = {Zech, Philipp and Schuch, Felipe and P{\´e}rez Chaparro, Camilo Germ{\´a}n Alberto and Kangas, Maria and Rapp, Michael A. and Heissel, Andreas},
title = {Exercise, Comorbidities, and Health-Related Quality of Life in People Living with HIV},
series = {International Journal of Environmental Research and Public Health},
volume = {17},
journal = {International Journal of Environmental Research and Public Health},
number = {14},
publisher = {MDPI AG},
address = {Basel},
issn = {1660-4601},
doi = {10.3390/ijerph17145138},
pages = {15},
year = {2020},
abstract = {(1) Background: People with HIV (PWH) may perform more than one type of exercise cumulatively. The objective of this study is to investigate recreational exercise and its association with health-related quality of life (HRQOL) and comorbidities in relation to potential covariates. (2) Methods: The HIBES study (HIV-Begleiterkrankungen-Sport) is a cross-sectional study for people with HIV. The differences between non-exercisers versus exercisers (cumulated vs. single type of exercises) were investigated using regression models based on 454 participants. (3) Results: Exercisers showed a higher HRQOL score compared to non-exercisers (Wilcox r = 0.2 to 0.239). Psychological disorders were identified as the main covariate. Participants performing exercise cumulatively showed higher scores in duration, frequency, and intensity when compared to participants performing only one type of exercise. The mental health summary score was higher for the cumulated and single type of exercise if a psychological disorder existed. Duration and intensity were associated with an increase of HRQOL, whilst a stronger association between psychological disorders and exercise variables were evident. Exercise duration (minutes) showed a significant effect on QOL (standardized beta = 0.1) and for participants with psychological disorders (standardized beta = 0.3), respectively. (4) Conclusions: Psychological disorders and other covariates have a prominent effect on HRQOL and its association with exercise. For PWH with a psychological disorder, a stronger relationship between HRQOL with exercise duration and intensity emerged. However, differentiation of high-HRQOL individuals warrants further investigation by considering additional factors.},
language = {en}
}
@article{KlugeRappMehranetal.2019,
author = {Kluge, Ulrike and Rapp, Michael A. and Mehran, Nassim and Abi Jumaa, Jinan and Aichberger, Marion Christina},
title = {Poverty, migration and mental health},
series = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie},
volume = {90},
journal = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie},
number = {11},
publisher = {Springer},
address = {New York},
issn = {0028-2804},
doi = {10.1007/s00115-019-00790-2},
pages = {1103 -- 1108},
year = {2019},
abstract = {Poverty and social exclusion are closely related to an increased risk for the deterioration of mental health. In 2018 approximately 19\% of the German population were threatened by poverty and the associated social ostracization. Migrant groups in particular often show an increased risk for poverty and are often exposed to multiple socioeconomic stress factors depending on the context of migration, pre-migration and post-migration social factors. Numerous studies have shown that societal exclusion, precarious living conditions and the residential environment negatively affect mental health beyond the effects of pre-migration risk factors. This article provides a review and discussion on the relationship between mental health, poverty and related constructs, such as social cohesion, social capital and social exclusion in general as well as in specific risk groups, such as migrant and refugee populations.},
language = {en}
}
@article{Rapp2019,
author = {Rapp, Michael A.},
title = {Die Versorgung f{\"u}r die n{\"a}chste Dekade sichern: Gerontopsychiatrie in der Krise?},
series = {Psychatrische Praxis},
volume = {46},
journal = {Psychatrische Praxis},
number = {6},
publisher = {Thieme},
address = {Stuttgart},
issn = {0303-4259},
doi = {10.1055/a-0971-5551},
pages = {305 -- 306},
year = {2019},
abstract = {Der demografische Wandel wird nicht nur mit einer rasanten Zunahme der Hochaltrigen einhergehen [1], was f{\"u}r die gerontopsychiatrische Versorgung aufgrund der altersassoziierten Inzidenzraten in erster Linie eine Zunahme an Demenzerkrankungen und Patienten mit Multimorbidit{\"a}t und Gebrechlichkeit bedeutet [2], sondern auch mit einer Zunahme j{\"u}ngerer alter Menschen vom 65. bis 75. Lebensjahr, was f{\"u}r die Gerontopsychiatrie eine Zunahme der Patienten mit Abh{\"a}ngigkeitserkrankungen, Erkrankungen aus dem schizophrenen Formenkreis und affektiven Erkrankungen bedeutet. Soziale Faktoren werden hier mehr und mehr eine zentrale Rolle spielen, da neben der Qualit{\"a}t der medizinischen Versorgung insbesondere die individuelle soziale Situation der Patienten mit einer erh{\"o}hten Morbidit{\"a}t und Mortalit{\"a}t einhergehen wird [3].},
language = {de}
}
@article{Rapp2019,
author = {Rapp, Michael A.},
title = {Alterspsychiatrie ist Teil ganzheitlicher Altersmedizin, kein Teilbereich der Psychiatrie - Kontra},
series = {Psychatrische Praxis},
volume = {46},
journal = {Psychatrische Praxis},
number = {6},
publisher = {Thieme},
address = {Stuttgart},
issn = {0303-4259},
doi = {10.1055/a-0958-8403},
pages = {308 -- 309},
year = {2019},
abstract = {Wenn in der Medizin vom demografischen Wandel gesprochen wird [1], wird zumeist von einer rasanten Zunahme der Hochaltrigen gesprochen, bei denen aufgrund der differenziellen altersassoziierten Inzidenzraten in erster Linie eine Zunahme an Demenzerkrankungen, kardiovaskul{\"a}ren Erkrankungen, Krebserkrankungen und allgemeiner Multimorbidit{\"a}t und Gebrechlichkeit zu erwarten ist [2]. Dies ist unstrittig richtig, aber nur ein Teil der Folgen des demografischen Wandels f{\"u}r die psychiatrische Versorgung. Diese muss weiterhin die gesamte adulte Lebensspanne im Blick haben, da sonst Versorgungsengp{\"a}sse bei ohnehin vulnerablen Patienten verst{\"a}rkt werden, mit Folgen f{\"u}r die Morbidit{\"a}t und Mortalit{\"a}t auf Bev{\"o}lkerungsebene [3].},
language = {de}
}
@article{BaltaBeylergilBeckDesernoetal.2017,
author = {Balta Beylergil, Sinem and Beck, Anne and Deserno, Lorenz and Lorenz, Robert C. and Rapp, Michael A. and Schlagenhauf, Florian and Heinz, Andreas and Obermayer, Klaus},
title = {Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence},
series = {NeuroImage: Clinical : a journal of diseases affecting the nervous system},
volume = {15},
journal = {NeuroImage: Clinical : a journal of diseases affecting the nervous system},
publisher = {Elsevier},
address = {Oxford},
issn = {2213-1582},
doi = {10.1016/j.nicl.2017.04.010},
pages = {80 -- 94},
year = {2017},
abstract = {Substance-dependent individuals often lack the ability to adjust decisions flexibly in response to the changes in reward contingencies. Prediction errors (PEs) are thought to mediate flexible decision-making by updating the reward values associated with available actions. In this study, we explored whether the neurobiological correlates of PEs are altered in alcohol dependence. Behavioral, and functional magnetic resonance imaging (fMRI) data were simultaneously acquired from 34 abstinent alcohol-dependent patients (ADP) and 26 healthy controls (HC) during a probabilistic reward-guided decision-making task with dynamically changing reinforcement contingencies. A hierarchical Bayesian inference method was used to fit and compare learning models with different assumptions about the amount of task-related information subjects may have inferred during the experiment. Here, we observed that the best-fitting model was a modified Rescorla-Wagner type model, the "double-update" model, which assumes that subjects infer the knowledge that reward contingencies are anti-correlated, and integrate both actual and hypothetical outcomes into their decisions. Moreover, comparison of the best-fitting model's parameters showed that ADP were less sensitive to punishments compared to HC. Hence, decisions of ADP after punishments were loosely coupled with the expected reward values assigned to them. A correlation analysis between the model-generated PEs and the fMRI data revealed a reduced association between these PEs and the BOLD activity in the dorsolateral prefrontal cortex (DLPFC) of ADP. A hemispheric asymmetry was observed in the DLPFC when positive and negative PE signals were analyzed separately. The right DLPFC activity in ADP showed a reduced correlation with positive PEs. On the other hand, ADP, particularly the patients with high dependence severity, recruited the left DLPFC to a lesser extent than HC for processing negative PE signals. These results suggest that the DLPFC, which has been linked to adaptive control of action selection, may play an important role in cognitive inflexibility observed in alcohol dependence when reinforcement contingencies change. Particularly, the left DLPFC may contribute to this impaired behavioral adaptation, possibly by impeding the extinction of the actions that no longer lead to a reward.},
language = {en}
}
@article{BangeowRapp2020,
author = {Bangeow, Petjo and Rapp, Michael A.},
title = {Beurteilung und Nutzung der 2016 reformierten Psychotherapierichtlinie},
series = {Psychiatrische Praxis : Sozialpsychiatrie, klinische Psychiatrie, public mental health, Versorgungsforschung},
volume = {47},
journal = {Psychiatrische Praxis : Sozialpsychiatrie, klinische Psychiatrie, public mental health, Versorgungsforschung},
number = {07},
publisher = {Thieme},
address = {Stuttgart},
issn = {0303-4259},
doi = {10.1055/a-1045-9820},
pages = {383 -- 387},
year = {2020},
abstract = {Ziel der Studie Dieser Artikel untersucht, inwiefern sich die 2016 reformierte Richtlinie im Stadt-Land- sowie im Ost-West-Vergleich auf die ambulante psychotherapeutische Arbeit und Versorgung auswirkt. Methodik Eine Onlineumfrage unter vertrags{\"a}rztlich t{\"a}tigen TherapeutInnen wurde durchgef{\"u}hrt. Die Fragen bezogen sich auf verschiedene Neuerungen in der Richtlinie. Ergebnisse Unabh{\"a}ngig von der Region sch{\"a}tzten die Befragten ein, dass die Reform zu keiner verbesserten Versorgung f{\"u}hrte. Im Westen und in der Stadt t{\"a}tige TherapeutInnen verwiesen PatientInnen nach der Sprechstunde {\"o}fter an andere Psychotherapiepraxen, im Osten und auf dem Land t{\"a}tige hingegen {\"o}fter auf andere Hilfeangebote. Schlussfolgerung St{\"a}rkere Anreize f{\"u}r die psychotherapeutische T{\"a}tigkeit auf dem Land sind zu schaffen. Abbaumaßnahmen der Ost-West-Ungleichheiten in der Versorgungsdichte scheinen n{\"o}tig.},
language = {de}
}
@article{BlockSchulzeDeekenetal.2021,
author = {Block, Andrea and Schulze, Susanne and Deeken, Friederike and H{\"a}usler, Andreas and Rezo, Anna and Rapp, Michael A. and Wippert, Pia-Maria},
title = {Effects of inflammatory markers and biographical stress on treatment response in depression},
series = {Psychoneuroendocrinology : an international journal ; the official journal of the International Society of Psychoneuroendocrinology},
volume = {131},
journal = {Psychoneuroendocrinology : an international journal ; the official journal of the International Society of Psychoneuroendocrinology},
number = {Supplement},
publisher = {Elsevier},
address = {Oxford},
issn = {0306-4530},
doi = {10.1016/j.psyneuen.2021.105535},
pages = {S24 -- S24},
year = {2021},
abstract = {Background Recent research emphasized the role of inflammatory processes in the pathophysiology of depression. Theories hypothesizes that life events (LE) can affect the immune system and trigger depressive symptoms. LE are also considered as one of the best predictors for the onset and course of depressive disorders. Methods Observational study across three treatment settings: n=208 depressive patients (75.5\%f, M 46.6 y) were examined on depression (BDI-II), life events (ILE) and inflammatory markers (IL-6, CRP, fibrinogen, ICAM-1, TNF-alpha, E-selectin) at baseline (t0), 5-week(t1) and 5-month(t2) follow-up. Effects and interactions were analyzed with regression models. Results LE were associated with depressive symptoms at t0 (beta=.209; p=.002) and both follow-ups. Except for CRP, which was linked to depression symptoms at t2 (betai=-.190; p=.032), there were no effects of inflammatory markers on depressive symptoms. At t1, an interaction between CRP and LE in total (beta=-.249; p=.041) was found as well as for LE in the past five years (beta=-.122; p=.027). Similar interactions were found between cumulative LE and ICAM-1 (beta=-.197; p=.003) and IL-6 (beta=-.425; p=.001). Conclusion The cumulative burden of LE effects symptoms and treatment outcome in depressive patients. There is some evidence that inflammatory marker may have long-term effects on treatment outcome as they seem to weaken the determining relation between LE and depression.},
language = {en}
}
@article{BangeowRapp2020,
author = {Bangeow, Petjo and Rapp, Michael A.},
title = {Beurteilung und Nutzung der 2016 reformierten Psychotherapierichtlinie},
series = {Psychiatrische Praxis},
volume = {47},
journal = {Psychiatrische Praxis},
number = {3},
publisher = {Thieme},
address = {Stuttgart},
issn = {0303-4259},
doi = {10.1055/a-1045-9801},
pages = {135 -- 141},
year = {2020},
abstract = {Objective This article investigates how aspects of 2016 reform of the German psychotherapeutic guideline were evaluated and used differently by therapists from three different psychotherapeutic treatment methods.
Methods An online survey was conducted with 987 statutory health insurance approved therapists. The questionnaire focused on various innovations in the guideline.
Results There were significant differences in the use of the broadened authority and of specific treatment services. There were also differences in the application for short-term and long-term psychotherapies as well as in the application to extend short to long-term psychotherapy.
Conclusions Elements of the guideline should be evaluated in relation to the preferred treatment method. Aspects related to the psychotherapeutic work with patients seem to be especially significant.},
language = {de}
}
@article{BrahmsHeinzelRappetal.2022,
author = {Brahms, Markus and Heinzel, Stephan and Rapp, Michael A. and M{\"u}ckstein, Marie and Hortob{\´a}gyi, Tibor and Stelzel, Christine and Granacher, Urs},
title = {The acute effects of mental fatigue on balance performance in healthy young and older adults - A systematic review and meta-analysis},
series = {Acta Psychologica},
volume = {225},
journal = {Acta Psychologica},
publisher = {Elsevier},
address = {Amsterdam},
issn = {1873-6297},
doi = {10.1016/j.actpsy.2022.103540},
pages = {1 -- 13},
year = {2022},
abstract = {Cognitive resources contribute to balance control. There is evidence that mental fatigue reduces cognitive resources and impairs balance performance, particularly in older adults and when balance tasks are complex, for example when trying to walk or stand while concurrently performing a secondary cognitive task. We conducted a systematic literature search in PubMed (MEDLINE), Web of Science and Google Scholar to identify eligible studies and performed a random effects meta-analysis to quantify the effects of experimentally induced mental fatigue on balance performance in healthy adults. Subgroup analyses were computed for age (healthy young vs. healthy older adults) and balance task complexity (balance tasks with high complexity vs. balance tasks with low complexity) to examine the moderating effects of these factors on fatigue-mediated balance performance. We identified 7 eligible studies with 9 study groups and 206 participants. Analysis revealed that performing a prolonged cognitive task had a small but significant effect (SMDwm = -0.38) on subsequent balance performance in healthy young and older adults. However, age- and task-related differences in balance responses to fatigue could not be confirmed statistically. Overall, aggregation of the available literature indicates that mental fatigue generally reduces balance in healthy adults. However, interactions between cognitive resource reduction, aging and balance task complexity remain elusive.},
language = {en}
}
@misc{GruebnerRappAdlietal.2017,
author = {Gruebner, Oliver and Rapp, Michael A. and Adli, Mazda and Kluge, Ulrike and Galea, Sandro and Heinz, Andreas},
title = {Cities and Mental Health},
series = {Deutsches {\"A}rzteblatt international : a weekly online journal of clinical medicine and public health},
volume = {114},
journal = {Deutsches {\"A}rzteblatt international : a weekly online journal of clinical medicine and public health},
number = {8},
publisher = {Dt. {\"A}rzte-Verl.},
address = {Cologne},
issn = {1866-0452},
doi = {10.3238/arztebl.2017.0121},
pages = {121 -- 127},
year = {2017},
abstract = {Background: More than half of the global population currently lives in cities, with an increasing trend for further urbanization. Living in cities is associated with increased population density, traffic noise and pollution, but also with better access to health care and other commodities. Methods: This review is based on a selective literature search, providing an overview of the risk factors for mental illness in urban centers. Results: Studies have shown that the risk for serious mental illness is generally higher in cities compared to rural areas. Epidemiological studies have associated growing up and living in cities with a considerably higher risk for schizophrenia. However, correlation is not causation and living in poverty can both contribute to and result from impairments associated with poor mental health. Social isolation and discrimination as well as poverty in the neighborhood contribute to the mental health burden while little is known about specific inter actions between such factors and the built environment. Conclusion: Further insights on the interaction between spatial heterogeneity of neighborhood resources and socio-ecological factors is warranted and requires interdisciplinary research.},
language = {en}
}
@misc{WippertBlockMansuyetal.2019,
author = {Wippert, Pia-Maria and Block, Andrea and Mansuy, Isabelle M. and Peters, Eva M. J. and Rose, Matthias and Rapp, Michael A. and Huppertz, Alexander and W{\"u}rtz-Kozak, Karin},
title = {Alterations in Bone Homeostasis and Microstructure Related to Depression and Allostatic Load},
series = {Psychotherapy and Psychosomatics},
volume = {88},
journal = {Psychotherapy and Psychosomatics},
number = {6},
publisher = {Karger},
address = {Basel},
issn = {0033-3190},
doi = {10.1159/000503640},
pages = {383 -- 385},
year = {2019},
language = {en}
}