@article{FriedelSchlagenhaufBecketal.2015,
author = {Friedel, Eva and Schlagenhauf, Florian and Beck, Anne and Dolan, Raymond J. and Huys, Quentin J. M. and Rapp, Michael A. and Heinz, Andreas},
title = {The effects of life stress and neural learning signals on fluid intelligence},
series = {European archives of psychiatry and clinical neuroscience : official organ of the German Society for Biological Psychiatry},
volume = {265},
journal = {European archives of psychiatry and clinical neuroscience : official organ of the German Society for Biological Psychiatry},
number = {1},
publisher = {Springer},
address = {Heidelberg},
issn = {0940-1334},
doi = {10.1007/s00406-014-0519-3},
pages = {35 -- 43},
year = {2015},
abstract = {Fluid intelligence (fluid IQ), defined as the capacity for rapid problem solving and behavioral adaptation, is known to be modulated by learning and experience. Both stressful life events (SLES) and neural correlates of learning [specifically, a key mediator of adaptive learning in the brain, namely the ventral striatal representation of prediction errors (PE)] have been shown to be associated with individual differences in fluid IQ. Here, we examine the interaction between adaptive learning signals (using a well-characterized probabilistic reversal learning task in combination with fMRI) and SLES on fluid IQ measures. We find that the correlation between ventral striatal BOLD PE and fluid IQ, which we have previously reported, is quantitatively modulated by the amount of reported SLES. Thus, after experiencing adversity, basic neuronal learning signatures appear to align more closely with a general measure of flexible learning (fluid IQ), a finding complementing studies on the effects of acute stress on learning. The results suggest that an understanding of the neurobiological correlates of trait variables like fluid IQ needs to take socioemotional influences such as chronic stress into account.},
language = {en}
}
@article{FoerstnerBoettgerMoldavskietal.2023,
author = {F{\"o}rstner, Bernd Rainer and B{\"o}ttger, Sarah Jane and Moldavski, Alexander and Bajbouj, Malek and Pfennig, Andrea and Manook, Andre and Ising, Marcus and Pittig, Andre and Heinig, Ingmar and Heinz, Andreas and Mathiak, Klaus and Schulze, Thomas G. and Schneider, Frank and Kamp-Becker, Inge and Meyer-Lindenberg, Andreas and Padberg, Frank and Banaschewski, Tobias and Bauer, Michael and Rupprecht, Rainer and Wittchen, Hans-Ulrich and Rapp, Michael A. and Tschorn, Mira},
title = {The associations of positive and negative valence systems, cognitive systems and social processes on disease severity in anxiety and depressive disorders},
series = {Frontiers in psychiatry},
volume = {14},
journal = {Frontiers in psychiatry},
publisher = {Frontiers Research Foundation},
address = {Lausanne},
issn = {1664-0640},
doi = {10.3389/fpsyt.2023.1161097},
pages = {10},
year = {2023},
abstract = {Background Anxiety and depressive disorders share common features of mood dysfunctions. This has stimulated interest in transdiagnostic dimensional research as proposed by the Research Domain Criteria (RDoC) approach by the National Institute of Mental Health (NIMH) aiming to improve the understanding of underlying disease mechanisms. The purpose of this study was to investigate the processing of RDoC domains in relation to disease severity in order to identify latent disorder-specific as well as transdiagnostic indicators of disease severity in patients with anxiety and depressive disorders. Methods Within the German research network for mental disorders, 895 participants (n = 476 female, n = 602 anxiety disorder, n = 257 depressive disorder) were recruited for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) and included in this cross-sectional study. We performed incremental regression models to investigate the association of four RDoC domains on disease severity in patients with affective disorders: Positive (PVS) and Negative Valance System (NVS), Cognitive Systems (CS) and Social Processes (SP). Results The results confirmed a transdiagnostic relationship for all four domains, as we found significant main effects on disease severity within domain-specific models (PVS: \& beta; = -0.35; NVS: \& beta; = 0.39; CS: \& beta; = -0.12; SP: \& beta; = -0.32). We also found three significant interaction effects with main diagnosis showing a disease-specific association. Limitations The cross-sectional study design prevents causal conclusions. Further limitations include possible outliers and heteroskedasticity in all regression models which we appropriately controlled for. Conclusion Our key results show that symptom burden in anxiety and depressive disorders is associated with latent RDoC indicators in transdiagnostic and disease-specific ways.},
language = {en}
}
@misc{BrahmsHeinzelRappetal.2022,
author = {Brahms, Markus and Heinzel, Stephan and Rapp, Michael A. and M{\"u}ckstein, Marie and Hortob{\´a}gyi, Tibor and Stelzel, Christine and Granacher, Urs},
title = {The acute effects of mental fatigue on balance performance in healthy young and older adults - A systematic review and meta-analysis},
series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
publisher = {Universit{\"a}tsverlag Potsdam},
address = {Potsdam},
issn = {1866-8364},
doi = {10.25932/publishup-56156},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-561560},
pages = {1 -- 13},
year = {2022},
abstract = {Cognitive resources contribute to balance control. There is evidence that mental fatigue reduces cognitive resources and impairs balance performance, particularly in older adults and when balance tasks are complex, for example when trying to walk or stand while concurrently performing a secondary cognitive task. We conducted a systematic literature search in PubMed (MEDLINE), Web of Science and Google Scholar to identify eligible studies and performed a random effects meta-analysis to quantify the effects of experimentally induced mental fatigue on balance performance in healthy adults. Subgroup analyses were computed for age (healthy young vs. healthy older adults) and balance task complexity (balance tasks with high complexity vs. balance tasks with low complexity) to examine the moderating effects of these factors on fatigue-mediated balance performance. We identified 7 eligible studies with 9 study groups and 206 participants. Analysis revealed that performing a prolonged cognitive task had a small but significant effect (SMDwm = -0.38) on subsequent balance performance in healthy young and older adults. However, age- and task-related differences in balance responses to fatigue could not be confirmed statistically. Overall, aggregation of the available literature indicates that mental fatigue generally reduces balance in healthy adults. However, interactions between cognitive resource reduction, aging and balance task complexity remain elusive.},
language = {en}
}
@article{BrahmsHeinzelRappetal.2022,
author = {Brahms, Markus and Heinzel, Stephan and Rapp, Michael A. and M{\"u}ckstein, Marie and Hortob{\´a}gyi, Tibor and Stelzel, Christine and Granacher, Urs},
title = {The acute effects of mental fatigue on balance performance in healthy young and older adults - A systematic review and meta-analysis},
series = {Acta Psychologica},
volume = {225},
journal = {Acta Psychologica},
publisher = {Elsevier},
address = {Amsterdam},
issn = {1873-6297},
doi = {10.1016/j.actpsy.2022.103540},
pages = {1 -- 13},
year = {2022},
abstract = {Cognitive resources contribute to balance control. There is evidence that mental fatigue reduces cognitive resources and impairs balance performance, particularly in older adults and when balance tasks are complex, for example when trying to walk or stand while concurrently performing a secondary cognitive task. We conducted a systematic literature search in PubMed (MEDLINE), Web of Science and Google Scholar to identify eligible studies and performed a random effects meta-analysis to quantify the effects of experimentally induced mental fatigue on balance performance in healthy adults. Subgroup analyses were computed for age (healthy young vs. healthy older adults) and balance task complexity (balance tasks with high complexity vs. balance tasks with low complexity) to examine the moderating effects of these factors on fatigue-mediated balance performance. We identified 7 eligible studies with 9 study groups and 206 participants. Analysis revealed that performing a prolonged cognitive task had a small but significant effect (SMDwm = -0.38) on subsequent balance performance in healthy young and older adults. However, age- and task-related differences in balance responses to fatigue could not be confirmed statistically. Overall, aggregation of the available literature indicates that mental fatigue generally reduces balance in healthy adults. However, interactions between cognitive resource reduction, aging and balance task complexity remain elusive.},
language = {en}
}
@misc{GellertHaeuslerSuhretal.2018,
author = {Gellert, Paul and H{\"a}usler, Andreas and Suhr, Ralf and Gholami, Maryam and Rapp, Michael A. and Kuhlmey, Adelheid and Nordheim, Johanna},
title = {Testing the stress-buffering hypothesis of social support in couples coping with early-stage dementia},
series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
number = {657},
issn = {1866-8364},
doi = {10.25932/publishup-44627},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-446270},
pages = {16},
year = {2018},
abstract = {Purpose To test whether the negative relationship between perceived stress and quality of life (Hypothesis 1) can be buffered by perceived social support in patients with dementia as well as in caregivers individually (Hypothesis 2: actor effects) and across partners (Hypothesis 3: partner effects and actor-partner effects). Method A total of 108 couples (N = 216 individuals) comprised of one individual with early-stage dementia and one caregiving partner were assessed at baseline and one month apart. Moderation effects were investigated by applying linear mixed models and actor-partner interdependence models. Results Although the stress-quality of life association was more pronounced in caregivers (beta = -.63, p<.001) compared to patients (beta= -.31, p<.001), this association was equally moderated by social support in patients (beta = .14, p<.05) and in the caregivers (beta =.13, p<.05). From one partner to his or her counterpart, the partner buffering and actor-partner-buffering effect were not present. Conclusion The stress-buffering effect has been replicated in individuals with dementia and caregivers but not across partners. Interventions to improve quality of life through perceived social support should not only focus on caregivers, but should incorporate both partners.},
language = {en}
}
@article{GellertHaeuslerSuhretal.2018,
author = {Gellert, Paul and H{\"a}usler, Andreas and Suhr, Ralf and Gholami, Maryam and Rapp, Michael A. and Kuhlmey, Adelheid and Nordheim, Johanna},
title = {Testing the stress-buffering hypothesis of social support in couples coping with early-stage dementia},
series = {PLoS one},
volume = {13},
journal = {PLoS one},
number = {1},
publisher = {PLoS},
address = {San Fransisco},
issn = {1932-6203},
doi = {10.1371/journal.pone.0189849},
pages = {14},
year = {2018},
abstract = {Purpose: To test whether the negative relationship between perceived stress and quality of life (Hypothesis 1) can be buffered by perceived social support in patients with dementia as well as in caregivers individually (Hypothesis 2: actor effects) and across partners (Hypothesis 3: partner effects and actor-partner effects). Method: A total of 108 couples (N = 216 individuals) comprised of one individual with early-stage dementia and one caregiving partner were assessed at baseline and one month apart. Moderation effects were investigated by applying linear mixed models and actor-partner interdependence models. Results: Although the stress-quality of life association was more pronounced in caregivers (beta = -.63, p<.001) compared to patients (beta= -.31, p<.001), this association was equally moderated by social support in patients (beta = .14, p<.05) and in the caregivers (beta =.13, p<.05). From one partner to his or her counterpart, the partner buffering and actor-partner-buffering effect were not present. Conclusion: The stress-buffering effect has been replicated in individuals with dementia and caregivers but not across partners. Interventions to improve quality of life through perceived social support should not only focus on caregivers, but should incorporate both partners.},
language = {en}
}
@article{DeekenRapp2022,
author = {Deeken, Friederike and Rapp, Michael A.},
title = {Technology-based interventions as an approach to treating apathy in people with dementia},
series = {International psychogeriatrics : the official journal of the International Psychogeriatric Association},
volume = {34},
journal = {International psychogeriatrics : the official journal of the International Psychogeriatric Association},
number = {2},
publisher = {Cambridge Univ. Press},
address = {Cambridge},
issn = {1741-203X},
doi = {10.1017/S1041610222000035},
pages = {95 -- 96},
year = {2022},
language = {en}
}
@article{ChenBelangerGarbusowetal.2023,
author = {Chen, Hao and Belanger, Matthew J. and Garbusow, Maria and Kuitunen-Paul, Soeren and Huys, Quentin J. M. and Heinz, Andreas and Rapp, Michael A. and Smolka, Michael N.},
title = {Susceptibility to interference between Pavlovian and instrumental control predisposes risky alcohol use developmental trajectory from ages 18 to 24},
series = {Addiction biology},
volume = {28},
journal = {Addiction biology},
number = {2},
publisher = {Wiley},
address = {Hoboken},
issn = {1355-6215},
doi = {10.1111/adb.13263},
pages = {18},
year = {2023},
abstract = {Pavlovian cues can influence ongoing instrumental behaviour via Pavlovian-to-instrumental transfer (PIT) processes. While appetitive Pavlovian cues tend to promote instrumental approach, they are detrimental when avoidance behaviour is required, and vice versa for aversive cues. We recently reported that susceptibility to interference between Pavlovian and instrumental control assessed via a PIT task was associated with risky alcohol use at age 18. We now investigated whether such susceptibility also predicts drinking trajectories until age 24, based on AUDIT (Alcohol Use Disorders Identification Test) consumption and binge drinking (gramme alcohol/drinking occasion) scores. The interference PIT effect, assessed at ages 18 and 21 during fMRI, was characterized by increased error rates (ER) and enhanced neural responses in the ventral striatum (VS), the lateral and dorsomedial prefrontal cortices (dmPFC) during conflict, that is, when an instrumental approach was required in the presence of an aversive Pavlovian cue or vice versa. We found that a stronger VS response during conflict at age 18 was associated with a higher starting point of both drinking trajectories but predicted a decrease in binge drinking. At age 21, high ER and enhanced neural responses in the dmPFC were associated with increasing AUDIT-C scores over the next 3 years until age 24. Overall, susceptibility to interference between Pavlovian and instrumental control might be viewed as a predisposing mechanism towards hazardous alcohol use during young adulthood, and the identified high-risk group may profit from targeted interventions.},
language = {en}
}
@misc{ChenNebeMojtahedzadehetal.2020,
author = {Chen, Hao and Nebe, Stephan and Mojtahedzadeh, Negin and Kuitunen-Paul, Soren and Garbusow, Maria and Schad, Daniel and Rapp, Michael A. and Huys, Quentin J. M. and Heinz, Andreas and Smolka, Michael N.},
title = {Susceptibility to interference between Pavlovian and instrumental control is associated with early hazardous alcohol use},
series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
number = {4},
issn = {1866-8364},
doi = {10.25932/publishup-56960},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-569609},
pages = {16},
year = {2020},
abstract = {Pavlovian-to-instrumental transfer (PIT) tasks examine the influence of Pavlovian stimuli on ongoing instrumental behaviour. Previous studies reported associations between a strong PIT effect, high-risk drinking and alcohol use disorder. This study investigated whether susceptibility to interference between Pavlovian and instrumental control is linked to risky alcohol use in a community sample of 18-year-old male adults. Participants (N = 191) were instructed to 'collect good shells' and 'leave bad shells' during the presentation of appetitive (monetary reward), aversive (monetary loss) or neutral Pavlovian stimuli. We compared instrumental error rates (ER) and functional magnetic resonance imaging (fMRI) brain responses between the congruent and incongruent conditions, as well as among high-risk and low-risk drinking groups. On average, individuals showed a substantial PIT effect, that is, increased ER when Pavlovian cues and instrumental stimuli were in conflict compared with congruent trials. Neural PIT correlates were found in the ventral striatum and the dorsomedial and lateral prefrontal cortices (lPFC). Importantly, high-risk drinking was associated with a stronger behavioural PIT effect, a decreased lPFC response and an increased neural response in the ventral striatum on the trend level. Moreover, high-risk drinkers showed weaker connectivity from the ventral striatum to the lPFC during incongruent trials. Our study links interference during PIT to drinking behaviour in healthy, young adults. High-risk drinkers showed higher susceptibility to Pavlovian cues, especially when they conflicted with instrumental behaviour, indicating lower interference control abilities. Increased activity in the ventral striatum (bottom-up), decreased lPFC response (top-down), and their altered interplay may contribute to poor interference control in the high-risk drinkers.},
language = {en}
}
@article{ChenNebeMojtahedzadehetal.2020,
author = {Chen, Hao and Nebe, Stephan and Mojtahedzadeh, Negin and Kuitunen-Paul, Soren and Garbusow, Maria and Schad, Daniel and Rapp, Michael A. and Huys, Quentin J. M. and Heinz, Andreas and Smolka, Michael N.},
title = {Susceptibility to interference between Pavlovian and instrumental control is associated with early hazardous alcohol use},
series = {Addiction biology},
volume = {26},
journal = {Addiction biology},
number = {4},
publisher = {Wiley},
address = {Hoboken},
issn = {1355-6215},
doi = {10.1111/adb.12983},
pages = {1 -- 14},
year = {2020},
abstract = {Pavlovian-to-instrumental transfer (PIT) tasks examine the influence of Pavlovian stimuli on ongoing instrumental behaviour. Previous studies reported associations between a strong PIT effect, high-risk drinking and alcohol use disorder. This study investigated whether susceptibility to interference between Pavlovian and instrumental control is linked to risky alcohol use in a community sample of 18-year-old male adults. Participants (N = 191) were instructed to 'collect good shells' and 'leave bad shells' during the presentation of appetitive (monetary reward), aversive (monetary loss) or neutral Pavlovian stimuli. We compared instrumental error rates (ER) and functional magnetic resonance imaging (fMRI) brain responses between the congruent and incongruent conditions, as well as among high-risk and low-risk drinking groups. On average, individuals showed a substantial PIT effect, that is, increased ER when Pavlovian cues and instrumental stimuli were in conflict compared with congruent trials. Neural PIT correlates were found in the ventral striatum and the dorsomedial and lateral prefrontal cortices (lPFC). Importantly, high-risk drinking was associated with a stronger behavioural PIT effect, a decreased lPFC response and an increased neural response in the ventral striatum on the trend level. Moreover, high-risk drinkers showed weaker connectivity from the ventral striatum to the lPFC during incongruent trials. Our study links interference during PIT to drinking behaviour in healthy, young adults. High-risk drinkers showed higher susceptibility to Pavlovian cues, especially when they conflicted with instrumental behaviour, indicating lower interference control abilities. Increased activity in the ventral striatum (bottom-up), decreased lPFC response (top-down), and their altered interplay may contribute to poor interference control in the high-risk drinkers.},
language = {en}
}
@inproceedings{NordheimRappKrauseKoehleretal.2014,
author = {Nordheim, J. and Rapp, Michael A. and Krause-Koehler, Kathleen and Niemann-Mirmehdi, M. and Haeusler, Andreas},
title = {Support for dementia affected Couples. Results of the DYADEM- study},
series = {Zeitschrift f{\"u}r Gerontologie und Geriatrie},
volume = {47},
booktitle = {Zeitschrift f{\"u}r Gerontologie und Geriatrie},
publisher = {Springer},
address = {Heidelberg},
issn = {0948-6704},
pages = {136 -- 136},
year = {2014},
language = {de}
}
@article{AichbergerMontesinosBromandetal.2015,
author = {Aichberger, Marion Christina and Montesinos, Amanda Heredia and Bromand, Zohra and Yesil, Rahsan and Temur-Erman, Selver and Rapp, Michael A. and Heinz, Andreas and Schouler-Ocak, Meryam},
title = {Suicide attempt rates and intervention effects in women of Turkish origin in Berlin},
series = {European psychiatry : the journal of the Association of European Psychiatrists},
volume = {30},
journal = {European psychiatry : the journal of the Association of European Psychiatrists},
number = {4},
publisher = {Elsevier},
address = {Paris},
issn = {0924-9338},
doi = {10.1016/j.eurpsy.2014.12.003},
pages = {480 -- 485},
year = {2015},
abstract = {Purpose: Ethnic minority groups show elevated suicide attempt rates across Europe. Evidence suggests a similar trend for women of Turkish origin in Germany, yet data on suicidal behaviour in minorities in Germany is scarce. The objective was to examine rates of suicidal behaviour, underlying motives, and to explore the effectiveness of an intervention program. Methods: From 05/2009-09/2011, data on all suicide attempts among women of Turkish origin who presented at a hospital-based emergency unit in Berlin, Germany, were collected. A multi-modal intervention was conducted in 2010 and the effects of age, generation and the intervention on suicide attempt rates were examined. Results: At the start, the highest rate was found in women aged 18-24 years with 225.4 (95\% CI = 208.8-242.0)/100,000. Adjustment disorder was the most prevalent diagnosis with 49.7\% (n = 79), being more common in second-generation women (P = .004). Further analyses suggested an effect of the intervention in the youngest age group (trend change of beta = -1.25; P = .017). Conclusion: Our findings suggest a particularly high rate of suicide attempts by 18-24-year-old, second-generation women of Turkish origin in Berlin. Furthermore, our results suggest a trend change in suicide attempts in women aged 18-24 years related to a population-based intervention program. (C) 2015 Elsevier Masson SAS. All rights reserved.},
language = {en}
}
@article{SeboldChenOenaletal.2022,
author = {Sebold, Miriam and Chen, Hao and {\"O}nal, Aleyna and Kuitunen-Paul, S{\"o}ren and Mojtahedzadeh, Negin and Garbusow, Maria and Nebe, Stephan and Wittchen, Hans-Ulrich and Huys, Quentin J. M. and Schlagenhauf, Florian and Rapp, Michael A. and Smolka, Michael N. and Heinz, Andreas},
title = {Stronger prejudices are associated with decreased model-based control},
series = {Frontiers in psychology},
volume = {12},
journal = {Frontiers in psychology},
publisher = {Frontiers Research Foundation},
address = {Lausanne},
issn = {1664-1078},
doi = {10.3389/fpsyg.2021.767022},
pages = {10},
year = {2022},
abstract = {Background: Prejudices against minorities can be understood as habitually negative evaluations that are kept in spite of evidence to the contrary. Therefore, individuals with strong prejudices might be dominated by habitual or "automatic" reactions at the expense of more controlled reactions. Computational theories suggest individual differences in the balance between habitual/model-free and deliberative/model-based decision-making. Methods: 127 subjects performed the two Step task and completed the blatant and subtle prejudice scale. Results: By using analyses of choices and reaction times in combination with computational modeling, subjects with stronger blatant prejudices showed a shift away from model-based control. There was no association between these decision-making processes and subtle prejudices. Conclusion: These results support the idea that blatant prejudices toward minorities are related to a relative dominance of habitual decision-making. This finding has important implications for developing interventions that target to change prejudices across societies.},
language = {en}
}
@article{SeboldSpittaGleichetal.2019,
author = {Sebold, Miriam and Spitta, G. and Gleich, T. and Dembler-Stamm, T. and Butler, Oisin and Zacharias, Kristin and Aydin, S. and Garbusow, Maria and Rapp, Michael A. and Schubert, Florian and Buchert, Ralph and Gallinat, J{\"u}rgen and Heinz, A.},
title = {Stressful life events are associated with striatal dopamine receptor availability in alcohol dependence},
series = {Journal of neural transmission},
volume = {126},
journal = {Journal of neural transmission},
number = {9},
publisher = {Springer},
address = {Wien},
issn = {0300-9564},
doi = {10.1007/s00702-019-01985-2},
pages = {1127 -- 1134},
year = {2019},
abstract = {Stress plays a key role in modulating addictive behavior and can cause relapse following periods of abstinence. Common effects of stress and alcohol on the dopaminergic system have been suggested, although the precise mechanisms are unclear. Here, we investigated 20 detoxified alcohol-dependent patients and 19 matched healthy controls and assessed striatal D2/D3 availability using [F-18]-fallypride positron emission tomography and stressful life events. We found a strong association between striatal D2/D3 availability and stress in patients, but not in healthy controls. Interestingly, we found increased D2/D3 receptor availability in patients with higher stress levels. This mirrors complex interactions between stress and alcohol intake in animal studies and emphasizes the importance to investigate stress exposure in neurobiological studies of addiction.},
language = {en}
}
@article{HeisselPietrekSchwefeletal.2020,
author = {Heissel, Andreas and Pietrek, Anou F. and Schwefel, Melanie and Abula, Kahar and Wilbertz, Gregor and Heinzel, Stephan and Rapp, Michael A.},
title = {STEP.De study},
series = {BMJ open},
volume = {10},
journal = {BMJ open},
number = {4},
publisher = {BMJ Publishing Group},
address = {London},
issn = {2044-6055},
doi = {10.1136/bmjopen-2019-036287},
pages = {10},
year = {2020},
abstract = {Introduction Although exercise therapy has widely been shown to be an efficacious treatment modality for depression, evidence for its effectiveness and cost efficiency is lacking. The Sport/Exercise Therapy for Depression study is a multicentre cluster-randomised effectiveness trial that aims to compare the effectiveness and cost efficiency of exercise therapy and psychotherapy as antidepressant treatment.
Methods and analysis 480 patients (aged 18-65) with an International Classification of Diseases diagnosis associated with depressive symptoms are recruited. Up to 30 clusters (psychotherapists) are randomly assigned to allocate patients to either an exercise or a psychotherapy treatment as usual in a 2: 1 ratio. The primary outcome (depressive symptoms) and the secondary outcomes (work and social adjustment, quality of life) will be assessed at six measurement time points (t0: baseline, t1: 8 weeks after treatment initiation, t2: 16 weeks after treatment initiation, t3/ 4/5: 2, 6, 12 months after treatment). Linear regression analyses will be used for the primary endpoint data analysis. For the secondary endpoints, mixed linear and logistic regression models with fixed and random factors will be added. For the cost efficiency analysis, expenditures in the 12 months before and after the intervention and the outcome difference will be compared between groups in a multilevel model. Recruitment start date was 1 July 2018 and the planned recruitment end date is 31 December 2020.
Ethics and dissemination The study protocol was approved by the ethics committee of the University of Potsdam (No. 17/2018) and the Freie Universitat Berlin (No. 206/2018) and registered in the ISRCTN registry. Informed written consent will be obtained from all participants. The study will be reported in accordance with the Consolidated Standards of Reporting Trials and the Recommendations for Interventional Trials statements. The results will be published in peer-reviewed academic journals and disseminated to the public.},
language = {en}
}
@inproceedings{SchadJuengerSeboldetal.2014,
author = {Schad, Daniel and Juenger, Elisabeth and Sebold, Miriam and Garbusow, Maria and Bernhart, Nadine and Javadi, Amir Homayoun and Zimmermann, Ulrich S. and Smolka, Michael N. and Heinz, Andreas and Rapp, Michael A. and Huys, Quentin J. M.},
title = {Smart goals, slow habits? Individual differences in processing speed and working memory capacity moderate the balance between habitual and goal-directed choice behavior},
series = {Cognitive processing : international quarterly of cognitive science},
volume = {15},
booktitle = {Cognitive processing : international quarterly of cognitive science},
number = {1},
publisher = {Springer},
address = {Heidelberg},
issn = {1612-4782},
pages = {S62 -- S62},
year = {2014},
language = {en}
}
@misc{HeinzVossLawrieetal.2016,
author = {Heinz, A. and Voss, M. and Lawrie, S. M. and Mishara, A. and Bauer, M. and Gallinat, J{\"u}rgen and Juckel, G. and Lang, U. and Rapp, Michael A. and Falkai, P. and Strik, W. and Krystal, J. and Abi-Dargham, A. and Galderisi, S.},
title = {Shall we really say goodbye to first rank symptoms?},
series = {European psychiatry : the journal of the Association of European Psychiatrists},
volume = {37},
journal = {European psychiatry : the journal of the Association of European Psychiatrists},
publisher = {Elsevier},
address = {Paris},
issn = {0924-9338},
doi = {10.1016/j.eurpsy.2016.04.010},
pages = {8 -- 13},
year = {2016},
abstract = {Background: First rank symptoms (FRS) of schizophrenia have been used for decades for diagnostic purposes. In the new version of the DSM-5, the American Psychiatric Association (APA) has abolished any further reference to FRS of schizophrenia and treats them like any other "criterion A' symptom (e.g. any kind of hallucination or delusion) with regard to their diagnostic implication. The ICD-10 is currently under revision and may follow suit. In this review, we discuss central points of criticism that are directed against the continuous use of first rank symptoms (FRS) to diagnose schizophrenia.},
language = {en}
}
@article{KalliesRappFydrichetal.2018,
author = {Kallies, Gunnar and Rapp, Michael A. and Fydrich, Thomas and Fehm, Lydia and Tschorn, Mira and Teran, Christina and Schwefel, Melanie and Pietrek, Anou F. and Henze, Romy and Hellweg, Rainer and Str{\"o}hle, Andreas and Heinzel, Stephan and Heissel, Andreas},
title = {Serum brain-derived neurotrophic factor (BDNF) at rest and after acute aerobic exercise in major depressive disorder},
series = {Psychoneuroendocrinology},
volume = {102},
journal = {Psychoneuroendocrinology},
publisher = {Elsevier},
address = {Oxford},
issn = {0306-4530},
doi = {10.1016/j.psyneuen.2018.12.015},
pages = {212 -- 215},
year = {2018},
abstract = {Physiological mechanisms of an anti-depressive effect of physical exercise in major depressive disorder (MDD) seem to involve alterations in brain-derived neurotrophic factor (BDNF) level. However, previous studies which investigated this effect in a single bout of exercise, did not control for confounding peripheral factors that contribute to BDNF-alterations. Therefore, the underlying cause of exercise-induced BDNF-changes remains unclear. The current study aims to investigate serum BDNF (sBDNF)-changes due to a single-bout of graded aerobic exercise in a group of 30 outpatients with MDD, suggesting a more precise analysis method by taking plasma volume shift and number of platelets into account. Results show that exercise-induced increases in sBDNF remain significant (p<.001) when adjusting for plasma volume shift and controlling for number of platelets. The interaction of sBDNF change and number of platelets was also significant (p=.001) indicating larger sBDNF-increase in participants with smaller number of platelets. Thus, findings of this study suggest an involvement of peripheral as well as additional possibly brain-derived mechanisms explaining exercise-related BDNF release in MDD. For future studies in the field of exercise-related BDNF research, the importance of controlling for peripheral parameters is emphasized.},
language = {en}
}
@misc{BookerJacobRappetal.2016,
author = {Booker, Anke and Jacob, Louis E. C. and Rapp, Michael A. and Bohlken, Jens and Kostev, Karel},
title = {Risk factors for dementia diagnosis in German primary care practices},
series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
number = {449},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-413441},
pages = {7},
year = {2016},
abstract = {Background: Dementia is a psychiatric condition the development of which is associated with numerous aspects of life. Our aim was to estimate dementia risk factors in German primary care patients. Methods: The case-control study included primary care patients (70-90 years) with first diagnosis of dementia (all-cause) during the index period (01/2010-12/2014) (Disease Analyzer, Germany), and controls without dementia matched (1:1) to cases on the basis of age, sex, type of health insurance, and physician. Practice visit records were used to verify that there had been 10 years of continuous follow-up prior to the index date. Multivariate logistic regression models were fitted with dementia as a dependent variable and the potential predictors. Results: The mean age for the 11,956 cases and the 11,956 controls was 80.4 (SD: 5.3) years. 39.0\% of them were male and 1.9\% had private health insurance. In the multivariate regression model, the following variables were linked to a significant extent with an increased risk of dementia: diabetes (OR: 1.17; 95\% CI: 1.10-1.24), lipid metabolism (1.07; 1.00-1.14), stroke incl. TIA (1.68; 1.57-1.80), Parkinson's disease (PD) (1.89; 1.64-2.19), intracranial injury (1.30; 1.00-1.70), coronary heart disease (1.06; 1.00-1.13), mild cognitive impairment (MCI) (2.12; 1.82-2.48), mental and behavioral disorders due to alcohol use (1.96; 1.50-2.57). The use of statins (OR: 0.94; 0.90-0.99), proton-pump inhibitors (PPI) (0.93; 0.90-0.97), and antihypertensive drugs (0.96, 0.94-0.99) were associated with a decreased risk of developing dementia. Conclusions: Risk factors for dementia found in this study are consistent with the literature. Nevertheless, the associations between statin, PPI and antihypertensive drug use, and decreased risk of dementia need further investigations.},
language = {en}
}
@article{BookerJacobRappetal.2016,
author = {Booker, Anke and Jacob, Louis E. C. and Rapp, Michael A. and Bohlken, Jens and Kostev, Karel},
title = {Risk factors for dementia diagnosis in German primary care practices},
series = {International psychogeriatrics},
volume = {28},
journal = {International psychogeriatrics},
publisher = {Cambridge Univ. Press},
address = {New York},
issn = {1041-6102},
doi = {10.1017/S1041610215002082},
pages = {1059 -- 1065},
year = {2016},
abstract = {Background: Dementia is a psychiatric condition the development of which is associated with numerous aspects of life. Our aim was to estimate dementia risk factors in German primary care patients. Methods: The case-control study included primary care patients (70-90 years) with first diagnosis of dementia (all-cause) during the index period (01/2010-12/2014) (Disease Analyzer, Germany), and controls without dementia matched (1:1) to cases on the basis of age, sex, type of health insurance, and physician. Practice visit records were used to verify that there had been 10 years of continuous follow-up prior to the index date. Multivariate logistic regression models were fitted with dementia as a dependent variable and the potential predictors. Conclusions: Risk factors for dementia found in this study are consistent with the literature. Nevertheless, the associations between statin, PPI and antihypertensive drug use, and decreased risk of dementia need further investigations.},
language = {en}
}
@inproceedings{HaegeleFriedelSchlagenhaufetal.2014,
author = {Haegele, Claudia and Friedel, Eva and Schlagenhauf, Florian and Sterzer, Philipp and Beck, Anne and Bermpohl, Felix and Rapp, Michael A. and Stoy, Meline and Stroehle, Andreas and Dolan, Raymond J. and Heinz, Andreas},
title = {Reward expectation and affective responses across psychiatric disorders - A dimensional approach},
series = {Biological psychiatry : a journal of psychiatric neuroscience and therapeutics ; a publication of the Society of Biological Psychiatry},
volume = {75},
booktitle = {Biological psychiatry : a journal of psychiatric neuroscience and therapeutics ; a publication of the Society of Biological Psychiatry},
number = {9},
publisher = {Elsevier},
address = {New York},
issn = {0006-3223},
pages = {91S -- 92S},
year = {2014},
language = {en}
}
@article{LorenzGleichBecketal.2014,
author = {Lorenz, Robert C. and Gleich, Tobias and Beck, Anne and Poehland, Lydia and Raufelder, Diana and Sommer, Werner and Rapp, Michael A. and Kuehn, Simone and Gallinat, J{\"u}rgen},
title = {Reward anticipation in the adolescent and aging brain},
series = {Human brain mapping : a journal devoted to functional neuroanatomy and neuroimaging},
volume = {35},
journal = {Human brain mapping : a journal devoted to functional neuroanatomy and neuroimaging},
number = {10},
publisher = {Wiley-Blackwell},
address = {Hoboken},
issn = {1065-9471},
doi = {10.1002/hbm.22540},
pages = {5153 -- 5165},
year = {2014},
abstract = {Processing of reward is the basis of adaptive behavior of the human being. Neural correlates of reward processing seem to be influenced by developmental changes from adolescence to late adulthood. The aim of this study is to uncover these neural correlates during a slot machine gambling task across the lifespan. Therefore, we used functional magnetic resonance imaging to investigate 102 volunteers in three different age groups: 34 adolescents, 34 younger adults, and 34 older adults. We focused on the core reward areas ventral striatum (VS) and ventromedial prefrontal cortex (VMPFC), the valence processing associated areas, anterior cingulate cortex (ACC) and insula, as well as information integration associated areas, dorsolateral prefrontal cortex (DLPFC), and inferior parietal lobule (IPL). Results showed that VS and VMPFC were characterized by a hyperactivation in adolescents compared with younger adults. Furthermore, the ACC and insula were characterized by a U-shape pattern (hypoactivation in younger adults compared with adolescents and older adults), whereas the DLPFC and IPL were characterized by a J-shaped form (hyperactivation in older adults compared with younger groups). Furthermore, a functional connectivity analysis revealed an elevated negative functional coupling between the inhibition-related area rIFG and VS in younger adults compared with adolescents. Results indicate that lifespan-related changes during reward anticipation are characterized by different trajectories in different reward network modules and support the hypothesis of an imbalance in maturation of striatal and prefrontal cortex in adolescents. Furthermore, these results suggest compensatory age-specific effects in fronto-parietal regions. Hum Brain Mapp 35:5153-5165, 2014. (c) 2014 Wiley Periodicals, Inc.},
language = {en}
}
@article{SeboldGarbusowJetzschmannetal.2019,
author = {Sebold, Miriam and Garbusow, Maria and Jetzschmann, P. and Schad, Daniel and Nebe, S. and Schlagenhauf, Florian and Heinz, A. and Rapp, Michael A. and Romanczuk-Seiferth, Nina},
title = {Reward and avoidance learning in the context of aversive environments and possible implications for depressive symptoms},
series = {Psychopharmacology},
volume = {236},
journal = {Psychopharmacology},
number = {8},
publisher = {Springer},
address = {New York},
issn = {0033-3158},
doi = {10.1007/s00213-019-05299-9},
pages = {2437 -- 2449},
year = {2019},
abstract = {Background Aversive stimuli in the environment influence human actions. This includes valence-dependent influences on action selection, e.g., increased avoidance but decreased approach behavior. However, it is yet unclear how aversive stimuli interact with complex learning and decision-making in the reward and avoidance domain. Moreover, the underlying computational mechanisms of these decision-making biases are unknown. Methods To elucidate these mechanisms, 54 healthy young male subjects performed a two-step sequential decision-making task, which allows to computationally model different aspects of learning, e.g., model-free, habitual, and model-based, goal-directed learning. We used a within-subject design, crossing task valence (reward vs. punishment learning) with emotional context (aversive vs. neutral background stimuli). We analyzed choice data, applied a computational model, and performed simulations. Results Whereas model-based learning was not affected, aversive stimuli interacted with model-free learning in a way that depended on task valence. Thus, aversive stimuli increased model-free avoidance learning but decreased model-free reward learning. The computational model confirmed this effect: the parameter lambda that indicates the influence of reward prediction errors on decision values was increased in the punishment condition but decreased in the reward condition when aversive stimuli were present. Further, by using the inferred computational parameters to simulate choice data, our effects were captured. Exploratory analyses revealed that the observed biases were associated with subclinical depressive symptoms. Conclusion Our data show that aversive environmental stimuli affect complex learning and decision-making, which depends on task valence. Further, we provide a model of the underlying computations of this affective modulation. Finally, our finding of increased decision-making biases in subjects reporting subclinical depressive symptoms matches recent reports of amplified Pavlovian influences on action selection in depression and suggests a potential vulnerability factor for mood disorders. We discuss our findings in the light of the involvement of the neuromodulators serotonin and dopamine.},
language = {en}
}
@article{BohlkenWeberSiebertetal.2017,
author = {Bohlken, Jens and Weber, Simon A. and Siebert, Anke and Forstmeier, Simon and Kohlmann, Thomas and Rapp, Michael A.},
title = {Reminiscence therapy for depression in dementia},
series = {GeroPsych - The Journal of gerontopsychology and geriatric psychiatry},
volume = {30},
journal = {GeroPsych - The Journal of gerontopsychology and geriatric psychiatry},
publisher = {Hogrefe},
address = {G{\"o}ttingen},
issn = {1662-9647},
doi = {10.1024/1662-9647/a000175},
pages = {145 -- 151},
year = {2017},
abstract = {We investigated the efficacy of reminiscence therapy (RT) on symptoms of depression in patients with mild to moderate dementia. Out of 227 patients with mild to moderate dementia from a specialized physician's office, 27 pairs (N = 54; mean age 79.04 ± 6.16 years) who had either received treatment as usual (TAU) or TAU combined with RT, were matched retrospectively according to age as well as cognitive and depressive symptom scores. After controlling for age and sex, symptoms of depression significantly decreased over time in the RT group compared to TAU (F1,52 = 4.36; p < .05). RT is a promising option for the treatment of depression in mild to moderate dementia. Larger randomized-controlled trials are needed.},
language = {en}
}
@misc{PerezChaparroSchuchZechetal.2021,
author = {P{\´e}rez Chaparro, Camilo Germ{\´a}n Alberto and Schuch, Felipe Barreto and Zech, Philipp and Kangas, Maria and Rapp, Michael A. and Heißel, Andreas},
title = {Recreational Exercising and Self-Reported Cardiometabolic Diseases in German People Living with HIV: A Cross-Sectional Study},
series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
volume = {18},
journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
edition = {21},
publisher = {Universit{\"a}tsverlag Potsdam},
address = {Potsdam},
issn = {1866-8364},
doi = {10.25932/publishup-55204},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-552049},
pages = {1 -- 10},
year = {2021},
abstract = {Exercise is known for its beneficial effects on preventing cardiometabolic diseases (CMDs) in the general population. People living with the human immunodeficiency virus (PLWH) are prone to sedentarism, thus raising their already elevated risk of developing CMDs in comparison to individuals without HIV. The aim of this cross-sectional study was to determine if exercise is associated with reduced risk of self-reported CMDs in a German HIV-positive sample (n = 446). Participants completed a self-report survey to assess exercise levels, date of HIV diagnosis, CD4 cell count, antiretroviral therapy, and CMDs. Participants were classified into exercising or sedentary conditions. Generalized linear models with Poisson regression were conducted to assess the prevalence ratio (PR) of PLWH reporting a CMD. Exercising PLWH were less likely to report a heart arrhythmia for every increase in exercise duration (PR: 0.20: 95\% CI: 0.10-0.62, p < 0.01) and diabetes mellitus for every increase in exercise session per week (PR: 0.40: 95\% CI: 0.10-1, p < 0.01). Exercise frequency and duration are associated with a decreased risk of reporting arrhythmia and diabetes mellitus in PLWH. Further studies are needed to elucidate the mechanisms underlying exercise as a protective factor for CMDs in PLWH.},
language = {en}
}
@article{PerezChaparroSchuchZechetal.2021,
author = {P{\´e}rez Chaparro, Camilo Germ{\´a}n Alberto and Schuch, Felipe Barreto and Zech, Philipp and Kangas, Maria and Rapp, Michael A. and Heißel, Andreas},
title = {Recreational exercising and self-reported cardiometabolic diseases in German people living with HIV},
series = {International journal of environmental research and public health : IJERPH / Molecular Diversity Preservation International},
volume = {18},
journal = {International journal of environmental research and public health : IJERPH / Molecular Diversity Preservation International},
number = {21},
publisher = {MDPI},
address = {Basel, Schweiz},
issn = {1660-4601},
doi = {10.3390/ijerph182111579},
pages = {1 -- 10},
year = {2021},
abstract = {Exercise is known for its beneficial effects on preventing cardiometabolic diseases (CMDs) in the general population. People living with the human immunodeficiency virus (PLWH) are prone to sedentarism, thus raising their already elevated risk of developing CMDs in comparison to individuals without HIV. The aim of this cross-sectional study was to determine if exercise is associated with reduced risk of self-reported CMDs in a German HIV-positive sample (n = 446). Participants completed a self-report survey to assess exercise levels, date of HIV diagnosis, CD4 cell count, antiretroviral therapy, and CMDs. Participants were classified into exercising or sedentary conditions. Generalized linear models with Poisson regression were conducted to assess the prevalence ratio (PR) of PLWH reporting a CMD. Exercising PLWH were less likely to report a heart arrhythmia for every increase in exercise duration (PR: 0.20: 95\% CI: 0.10-0.62, p < 0.01) and diabetes mellitus for every increase in exercise session per week (PR: 0.40: 95\% CI: 0.10-1, p < 0.01). Exercise frequency and duration are associated with a decreased risk of reporting arrhythmia and diabetes mellitus in PLWH. Further studies are needed to elucidate the mechanisms underlying exercise as a protective factor for CMDs in PLWH.},
language = {en}
}
@article{PerezChaparroKangasZechetal.2022,
author = {P{\´e}rez Chaparro, Camilo Germ{\´a}n Alberto and Kangas, Maria and Zech, Philipp and Schuch, Felipe B. and Rapp, Michael A. and Heißel, Andreas},
title = {Recreational exercise is associated with lower prevalence of depression and anxiety and better quality of life in German people living with HIV},
series = {AIDS care : psychological and socio-medical aspects of AIDS/HIV},
volume = {34},
journal = {AIDS care : psychological and socio-medical aspects of AIDS/HIV},
number = {2},
publisher = {Taylor \& Francis Group},
address = {London [u.a.]},
issn = {1360-0451},
doi = {10.1080/09540121.2021.1889951},
pages = {182 -- 187},
year = {2022},
abstract = {Sedentarism is a risk factor for depression and anxiety. People living with the human immunodeficiency virus (PLWH) have a higher prevalence of anxiety and depression compared to HIV-negative individuals. This cross-sectional study (n = 450, median age 44 (19-75), 7.3\% females) evaluates the prevalence rates and prevalence ratio (PR) of anxiety and/or depression in PLWH associated with recreational exercise. A decreased likelihood of having anxiety (PR=0.57; 0.36-0.91; p = 0.01), depression (PR=0.41; 0.36-0.94; p=0.01), and comorbid anxiety and depression (PR = 0,43; 0.24-0.75; p=0.002) was found in exercising compared to non-exercising PLWH. Recreational exercise is associated with a lower risk for anxiety and/or depression. Further prospective studies are needed to provide insights on the direction of this association.},
language = {en}
}
@unpublished{HeinzCharletRapp2015,
author = {Heinz, Andreas and Charlet, Katrin and Rapp, Michael A.},
title = {Public mental health: a call to action},
series = {World psychiatry},
volume = {14},
journal = {World psychiatry},
number = {1},
publisher = {Wiley-Blackwell},
address = {Hoboken},
issn = {1723-8617},
doi = {10.1002/wps.20182},
pages = {49 -- 50},
year = {2015},
language = {en}
}
@article{SchulzeMerzThieretal.2022,
author = {Schulze, Susanne and Merz, Sibille and Thier, Anne and Tallarek, Marie and K{\"o}nig, Franziska and Uhlenbrock, Greta and N{\"u}bling, Matthias and Lincke, Hans-Joachim and Rapp, Michael A. and Spallek, Jacob and Holmberg, Christine},
title = {Psychosocial burden in nurses working in nursing homes during the Covid-19 pandemic},
series = {BMC health services research},
volume = {22},
journal = {BMC health services research},
number = {1},
publisher = {BMC},
address = {London},
issn = {1472-6963},
doi = {10.1186/s12913-022-08333-3},
pages = {13},
year = {2022},
abstract = {Background The Covid-19 pandemic led to increased work-related strain and psychosocial burden in nurses worldwide, resulting in high prevalences of mental health problems. Nurses in long-term care facilities seem to be especially affected by the pandemic. Nevertheless, there are few findings indicating possible positive changes for health care workers. Therefore, we investigated which psychosocial burdens and potential positive aspects nurses working in long-term care facilities experience during the Covid-19 pandemic. Methods We conducted a mixed-methods study among nurses and nursing assistants working in nursing homes in Germany. The survey contained the third German version of the Copenhagen Psychosocial Questionnaire (COPSOQ III). Using Welch's t-tests, we compared the COPSOQ results of our sample against a pre-pandemic reference group of geriatric nurses from Germany. Additionally, we conducted semi-structured interviews with geriatric nurses with a special focus on psychosocial stress, to reach a deeper understanding of their experiences on work-related changes and burdens during the pandemic. Data were analysed using thematic coding (Braun and Clarke). Results Our survey sample (n = 177) differed significantly from the pre-pandemic reference group in 14 out of 31 COPSOQ scales. Almost all of these differences indicated negative changes. Our sample scored significantly worse regarding the scales 'quantitative demands', 'hiding emotions', 'work-privacy conflicts', 'role conflicts', 'quality of leadership', 'support at work', 'recognition', 'physical demands', 'intention to leave profession', 'burnout', 'presenteeism' and 'inability to relax'. The interviews (n = 15) revealed six main themes related to nurses' psychosocial stress: 'overall working conditions', 'concern for residents', 'management of relatives', 'inability to provide terminal care', 'tensions between being infected and infecting others' and 'technicisation of care'. 'Enhanced community cohesion' (interviews), 'meaning of work' and 'quantity of social relations' (COPSOQ III) were identified as positive effects of the pandemic. Conclusions Results clearly illustrate an aggravation of geriatric nurses' situation and psychosocial burden and only few positive changes due to the Covid-19 pandemic. Pre-existing hardships seem to have further deteriorated and new stressors added to nurses' strain. The perceived erosion of care, due to an overemphasis of the technical in relation to the social and emotional dimensions of care, seems to be especially burdensome to geriatric nurses.},
language = {en}
}
@article{DeekenHaeuslerNordheimetal.2017,
author = {Deeken, Friederike and H{\"a}usler, Andreas and Nordheim, Johanna and Rapp, Michael A. and Knoll, Nina and Rieckmann, Nina},
title = {Psychometric properties of the Perceived Stress Scale in a sample of German dementia patients and their caregivers},
series = {International psychogeriatrics},
volume = {30},
journal = {International psychogeriatrics},
number = {1},
publisher = {Cambridge Univ. Press},
address = {New York},
issn = {1041-6102},
doi = {10.1017/S1041610217001387},
pages = {39 -- 47},
year = {2017},
abstract = {Background: The aim of the present study was to investigate the psychometric characteristics of the Perceived Stress Scale (PSS) in a sample of dementia patients and their spousal caregivers. Methods: We investigated the reliability and validity of the 14-item PSS in a sample of 80 couples, each including one spouse who had been diagnosed with mild to moderate dementia (mean age 75.55, SD = 5.85, 38.7\% female) and one spousal caregiver (mean age 73.06, SD = 6.75, 61.3\% female). We also examined the factor structure and sensitivity of the scale with regard to gender differences. Results: Exploratory factor analysis of the PSS revealed a two-factor solution for the scale; the first factor reflected general stress while the second factor consisted of items reflecting the perceived ability to cope with stressors. A confirmatory factor analysis verified that the data were a better fit for the two-factor model than a one-factor model. The two factors of the PSS showed good reliability for patients as well as for caregivers ranging between alpha = 0.73 and alpha = 0.82. Perceived stress was significantly positively correlated with depressive symptomatology in both caregivers and patients. Mean PSS scores did not significantly differ between male and female patients nor did they differ between male and female caregivers. Conclusion: The present data indicate that the PSS provides a reliable and valid measure of perceived stress in dementia patients and their caregivers.},
language = {en}
}
@article{SchadJuengerSeboldetal.2014,
author = {Schad, Daniel and Juenger, Elisabeth and Sebold, Miriam and Garbusow, Maria and Bernhardt, Nadine and Javadi, Amir-Homayoun and Zimmermann, Ulrich S. and Smolka, Michael N. and Heinz, Andreas and Rapp, Michael A. and Huys, Quentin J. M.},
title = {Processing speed enhances model-based over model-free reinforcement learning in the presence of high working memory functioning},
series = {Frontiers in psychology},
volume = {5},
journal = {Frontiers in psychology},
publisher = {Frontiers Research Foundation},
address = {Lausanne},
issn = {1664-1078},
doi = {10.3389/fpsyg.2014.01450},
pages = {10},
year = {2014},
abstract = {Theories of decision-making and its neural substrates have long assumed the existence of two distinct and competing valuation systems, variously described as goal-directed vs. habitual, or, more recently and based on statistical arguments, as model-free vs. model-based reinforcement-learning. Though both have been shown to control choices, the cognitive abilities associated with these systems are under ongoing investigation. Here we examine the link to cognitive abilities, and find that individual differences in processing speed covary with a shift from model-free to model-based choice control in the presence of above-average working memory function. This suggests shared cognitive and neural processes; provides a bridge between literatures on intelligence and valuation; and may guide the development of process models of different valuation components. Furthermore, it provides a rationale for individual differences in the tendency to deploy valuation systems, which may be important for understanding the manifold neuropsychiatric diseases associated with malfunctions of valuation.},
language = {en}
}
@misc{StroehleRapp2016,
author = {Stroehle, Andreas and Rapp, Michael A.},
title = {Prevention of Cognitive Decline: A Physical Exercise Perspective on Brain Health in the Long Run},
series = {Journal of the American Medical Directors Association},
volume = {17},
journal = {Journal of the American Medical Directors Association},
publisher = {Elsevier},
address = {New York},
issn = {1525-8610},
doi = {10.1016/j.jamda.2016.02.030},
pages = {461 -- 462},
year = {2016},
language = {en}
}
@article{DrosselmeyerRappKostev2016,
author = {Drosselmeyer, Julia and Rapp, Michael A. and Kostev, Karel},
title = {Prevalence and type of antidepressant therapy used by German general practitioners to treat female patients with osteoporosis},
series = {International journal of clinical pharmacology and therapeutics},
volume = {54},
journal = {International journal of clinical pharmacology and therapeutics},
publisher = {Dustri-Verlag Dr. Karl Feistle},
address = {Deisenhofen-M{\~A}¼nchen},
issn = {0946-1965},
doi = {10.5414/CP202610},
pages = {743 -- 749},
year = {2016},
abstract = {Objective: To estimate the prevalence and type of antidepressant medication prescribed by German primary care physicians for patients with depression and osteoporosis. Methods: This study was a retrospective database analysis conducted in Germany utilizing the Disease Analyzer (R) Database (IMS Health, Germany). The study population included 3,488 female osteoporosis patients aged between 40 and 90 years recruited from 1,179 general practitioner practices and who were initially diagnosed with depression during the index period (January 2004 to December 2013). Follow-up lasted up to 12 months and was completed in August 2015. Also included in this study were 3,488 nonosteoporosis controls who were matched (1 : 1) to osteoporosis cases on the basis of age, health insurance coverage, severity of depression, and physician carrying out the diagnosis. Results: After 12 months of followup, 30.1\% of osteoporosis and 29.9\% of nonosteoporosis patients with mild depression (p = 0.783), 52.4\% of osteoporosis and 48.0\% of non-osteoporosis patients with moderate depression (p = 0.003), and 39.4\% of osteoporosis and 35.1\% of nonosteoporosis patients with severe depression (p = 0.147) were being treated with antidepressants. Osteoporosis patients with moderate depression had a higher chance of being prescribed antidepressant therapy at the initial diagnosis (hazard ratio (HR): 1.12, p = 0.014). No differences were found between osteoporosis and nonosteoporosis patients regarding the proportion of patients receiving selective serotonin reuptake inhibitors (SSRI)/serotonin-noradrenaline reuptake inhibitors (SNRI), tricyclic antidepressant (TCA), or other antidepressants. Osteoporosis patients were more often referred to hospitals or psychiatrists for consultation. Conclusion: Osteoporosis patients are more often treated initially with antidepressants than non-osteoporosis patients, especially within the groups of patients with moderate or severe depression. TCA was the most frequently used antidepressant therapy class on initial diagnosis in both patient groups. Osteo-porosis patients receive referrals to hospitals or psychiatrists more often than patients without osteoporosis.},
language = {en}
}
@article{HeinzelLorenzQuynhLamDuongetal.2017,
author = {Heinzel, Stephan and Lorenz, Robert C. and Quynh-Lam Duong, and Rapp, Michael A. and Deserno, Lorenz},
title = {Prefrontal-parietal effective connectivity during working memory in older adults},
series = {Neurobiology of Aging},
volume = {57},
journal = {Neurobiology of Aging},
publisher = {Elsevier},
address = {New York},
issn = {0197-4580},
doi = {10.1016/j.neurobiolaging.2017.05.005},
pages = {18 -- 27},
year = {2017},
abstract = {Theoretical models and preceding studies have described age-related alterations in neuronal activation of frontoparietal regions in a working memory (WM)load-dependent manner. However, to date, underlying neuronal mechanisms of these WM load-dependent activation changes in aging remain poorly understood. The aim of this study was to investigate these mechanisms in terms of effective connectivity by application of dynamic causal modeling with Bayesian Model Selection. Eighteen healthy younger (age: 20-32 years) and 32 older (60-75 years) participants performed an n-back task with 3 WM load levels during functional magnetic resonance imaging (fMRI). Behavioral and conventional fMRI results replicated age group by WM load interactions. Importantly, the analysis of effective connectivity derived from dynamic causal modeling, indicated an age-and performance-related reduction in WM load-dependent modulation of connectivity from dorsolateral prefrontal cortex to inferior parietal lobule. This finding provides evidence for the proposal that age-related WM decline manifests as deficient WM load-dependent modulation of neuronal top-down control and can integrate implications from theoretical models and previous studies of functional changes in the aging brain.},
language = {en}
}
@article{TschornSchulzeFoerstneretal.2022,
author = {Tschorn, Mira and Schulze, Susanne and F{\"o}rstner, Bernd Rainer and Holmberg, Christine and Spallek, Jacob and Heinz, Andreas and Rapp, Michael A.},
title = {Predictors and prevalence of hazardous alcohol use in middle-late to late adulthood in Europe},
series = {Aging \& mental health},
volume = {27},
journal = {Aging \& mental health},
number = {5},
publisher = {Routledge, Taylor \& Francis Group},
address = {Abingdon},
issn = {1360-7863},
doi = {10.1080/13607863.2022.2076208},
pages = {1001 -- 1010},
year = {2022},
abstract = {Objectives: Even low to moderate levels of alcohol consumption can have detrimental health consequences, especially in older adults (OA). Although many studies report an increase in the proportion of drinkers among OA, there are regional variations. Therefore, we examined alcohol consumption and the prevalence of hazardous alcohol use (HAU) among men and women aged 50+ years in four European regions and investigated predictors of HAU. Methods: We analyzed data of N = 35,042 participants of the European SHARE study. We investigated differences in alcohol consumption (units last week) according to gender, age and EU-region using ANOVAs. Furthermore, logistic regression models were used to examine the effect of income, education, marital status, history of a low-quality parent-child relationship and smoking on HAU, also stratified for gender and EU-region. HAU was operationalized as binge drinking or risky drinking (<12.5 units of 10 ml alcohol/week). Results: Overall, past week alcohol consumption was 5.0 units (+/- 7.8), prevalence of HAU was 25.4\% within our sample of European adults aged 50+ years. Male gender, younger age and living in Western Europe were linked to both higher alcohol consumption and higher risks of HAU. Income, education, smoking, a low-quality parent-child relationship, living in Northern and especially Eastern Europe were positively associated with HAU. Stratified analyses revealed differences by region and gender. Conclusions: HAU was highly prevalent within this European sample of OA. Alcohol consumption and determinants of HAU differed between EU-regions, hinting to a necessity of risk-stratified population-level strategies to prevent HAU and subsequent alcohol use disorders.},
language = {en}
}
@article{KlugeRappMehranetal.2019,
author = {Kluge, Ulrike and Rapp, Michael A. and Mehran, Nassim and Abi Jumaa, Jinan and Aichberger, Marion Christina},
title = {Poverty, migration and mental health},
series = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie},
volume = {90},
journal = {Der Nervenarzt : Organ der Deutschen Gesellschaft f{\"u}r Psychiatrie, Psychotherapie und Nervenheilkunde ; Mitteilungsblatt der Deutschen Gesellschaft f{\"u}r Neurologie},
number = {11},
publisher = {Springer},
address = {New York},
issn = {0028-2804},
doi = {10.1007/s00115-019-00790-2},
pages = {1103 -- 1108},
year = {2019},
abstract = {Poverty and social exclusion are closely related to an increased risk for the deterioration of mental health. In 2018 approximately 19\% of the German population were threatened by poverty and the associated social ostracization. Migrant groups in particular often show an increased risk for poverty and are often exposed to multiple socioeconomic stress factors depending on the context of migration, pre-migration and post-migration social factors. Numerous studies have shown that societal exclusion, precarious living conditions and the residential environment negatively affect mental health beyond the effects of pre-migration risk factors. This article provides a review and discussion on the relationship between mental health, poverty and related constructs, such as social cohesion, social capital and social exclusion in general as well as in specific risk groups, such as migrant and refugee populations.},
language = {en}
}
@article{BohlkenSchulzRappetal.2015,
author = {Bohlken, Jens and Schulz, Mandy and Rapp, Michael A. and Baetzing-Feigenbaum, Joerg},
title = {Pharmacotherapy of dementia in Germany: Results from a nationwide claims database},
series = {European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
volume = {25},
journal = {European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
number = {12},
publisher = {Elsevier},
address = {Amsterdam},
issn = {0924-977X},
doi = {10.1016/j.euroneuro.2015.09.014},
pages = {2333 -- 2338},
year = {2015},
abstract = {In 2011, about 1.1-1.4 million patients with dementia were living in Germany, a number expected to rise to three million by 2050. Dementia poses a major challenge to the healthcare system and neuropharmacological service provision. The aim of this study was to determine prescription rates for anti-dementia drugs as well as for neuroleptics, sedative-hypnotics and antidepressants in dementia using the complete nationwide outpatient claims data pertaining to the services of statutory health insurance. We controlled for gender, age, dementia diagnosis, physician specialty (general practitioner GP versus neuropsychiatry specialist physician NPSP), and rural and urban living area. In about one million prevalent dementia patients (N=1,014,710) in 2011, the prescription prevalence rate of anti-dementia drugs was 24.6\%; it varied with gender, age, and diagnosis (highest in Alzheimer's disease; 42\%), and was higher in patients treated by NPSPs (48\% vs. 25\% in GPs). At the same time, we found an alarmingly high rate of treatment with neuroleptics in dementia patients (35\%), with an only slightly decreased risk in patients treated exclusively by NPSPs (OR=0.86). We found marginal differences between rural and urban areas. Our results show that the majority of anti-dementia drug prescriptions appear guideline-oriented, yet prescription rates are overall comparatively low. On the other hand, neuroleptic drugs, which are associated with excess morbidity and mortality in dementia, were prescribed very frequently, suggesting excess use given current guidelines. We therefore suggest that guideline implementation measures and increasing quality control procedures are needed with respect to the pharmacotherapy of this vulnerable population. (C) 2015 Elsevier B.V. and ECNR All rights reserved.},
language = {en}
}
@article{BookersJacobBohlkenetal.2016,
author = {Bookers, Anke and Jacob, Louis and Bohlken, Jens and Rapp, Michael A. and Kostev, Karel},
title = {Persistence with antipsychotics in dementia patients in Germany},
series = {International journal of clinical pharmacology and therapeutics},
volume = {54},
journal = {International journal of clinical pharmacology and therapeutics},
publisher = {Dustri-Verlag Dr. Karl Feistle},
address = {Deisenhofen-M{\~A}¼nchen},
issn = {0946-1965},
doi = {10.5414/CP202631},
pages = {835 -- 840},
year = {2016},
abstract = {Background/Aims: To analyze the duration of treatment with antipsychotics in German dementia patients. Methods: This study included patients aged 60 years and over with dementia who received a first-time antipsychotic prescription by psychiatrists between 2009 and 2013. The main outcome measure was the treatment rate for more than 6 months following the index date. Results: A total of 12,979 patients with dementia (mean age 82 years, 52.1\% living in nursing homes) were included. After 2 years of follow-up, 54.8\%, 57.2\%, 61.1\%, and 65.4\% of patients aged 60 - 69, 70 - 79, 80 - 89, and 90 - 99 years, respectively, received antipsychotic prescriptions. 63.9\% of subjects living in nursing homes and 55.0\% of subjects living at home also continued their treatment (p-value < 0.001). Conclusion: The percentage of dementia patients treated with anti psychotics is very high.},
language = {en}
}
@article{BookerBohlkenRappetal.2016,
author = {Booker, Anke and Bohlken, Jens and Rapp, Michael A. and Kostev, Karel},
title = {Persistence with antidepressant drugs in patients with dementia: a retrospective database analysis},
series = {International journal of clinical pharmacology and therapeutics},
volume = {54},
journal = {International journal of clinical pharmacology and therapeutics},
publisher = {Dustri-Verlag Dr. Karl Feistle},
address = {Deisenhofen-M{\~A}¼nchen},
issn = {0946-1965},
doi = {10.5414/CP202572},
pages = {323 -- 329},
year = {2016},
abstract = {Background: The aims of the present study are to determine what proportion of patients with dementia receives antidepressants, how long the treatment is administered, and what factors increase the risk of discontinuation. Methods: The study was based on Disease Analyzer database and included 1,203 general practitioners (GP) and 209 neurologists/psychiatrists (NP). 12,281 patients with a diagnosis of dementia and an initial prescription of an antidepressant drug between January 2004 and December 2013 were included. The main outcome measure was antidepressant discontinuation rates within 6 months of the index date. Results: After 6 months of follow-up, 52.7\% of dementia patients treated with antidepressants had stopped medication intake. There was a significantly decreased risk for treatment discontinuation for patients using selective serotonin reuptake inhibitors (SSRRIs) or serotonin and norepinephrine reuptake inhibitors (SSNRIs) compared to tricyclic antidepressants. There was a significantly increased risk of treatment discontinuation for older patients and patients treated in NP practice. Comorbidity of diabetes or history of stroke was associated with a decreased risk of treatment discontinuation. Conclusion: The study results show insufficient persistence in antidepressant treatment in dementia patients in a real world setting. The improvement must be achieved to ensure the treatment recommended in the guidelines.},
language = {en}
}
@article{HaeuslerSanchezGellertetal.2016,
author = {H{\"a}usler, Andreas and S{\´a}nchez, Alba and Gellert, Paul and Deeken, Friederike and Rapp, Michael A. and Nordheim, Johanna},
title = {Perceived stress and quality of life in dementia patients and their caregiving spouses: does dyadic coping matter?},
series = {International psychogeriatrics},
volume = {28},
journal = {International psychogeriatrics},
publisher = {Cambridge Univ. Press},
address = {New York},
issn = {1041-6102},
doi = {10.1017/S1041610216001046},
pages = {1857 -- 1866},
year = {2016},
abstract = {Background: Given the well-established association between perceived stress and quality of life (QoL) in dementia patients and their partners, our goal was to identify whether relationship quality and dyadic coping would operate as mediators between perceived stress and QoL. Results: We found negative correlations between stress and QoL in both partners (QoL-AD: r = -0.62; p < 0.001; WHO-QOL Overall: r = -0.27; p = 0.02). Spousal caregivers had a significantly lower DCI total score than dementia patients (p < 0.001). Dyadic coping was a significant mediator of the relationship between stress and QoL in spousal caregivers (z = 0.28; p = 0.02), but not in dementia patients. Likewise, relationship quality significantly mediated the relationship between stress and QoL in caregivers only (z = -2.41; p = 0.02). Conclusions: This study identified dyadic coping as a mediator on the relationship between stress and QoL in (caregiving) partners of dementia patients. In patients, however, we found a direct negative effect of stress on QoL. The findings suggest the importance of stress reducing and dyadic interventions for dementia patients and their partners, respectively.},
language = {en}
}
@misc{HaeuslerSanchezGellertetal.2016,
author = {H{\"a}usler, Andreas and S{\´a}nchez, Alba and Gellert, Paul and Deeken, Friederike and Nordheim, Johanna and Rapp, Michael A.},
title = {Perceived stress and quality of life in dementia patients and their caregiving spouses},
series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
number = {448},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-413464},
pages = {10},
year = {2016},
abstract = {Background: Given the well-established association between perceived stress and quality of life (QoL) in dementia patients and their partners, our goal was to identify whether relationship quality and dyadic coping would operate as mediators between perceived stress and QoL. Methods: 82 dyads of dementia patients and their spousal caregivers were included in a cross-sectional assessment from a prospective study. QoL was assessed with the Quality of Life in Alzheimer's Disease scale (QoL-AD) for dementia patients and the WHO Quality of Life-BREF for spousal caregivers. Perceived stress was measured with the Perceived Stress Scale (PSS-14). Both partners were assessed with the Dyadic Coping Inventory (DCI). Analyses of correlation as well as regression models including mediator analyses were performed. Results: We found negative correlations between stress and QoL in both partners (QoL-AD: r = -0.62; p < 0.001; WHO-QOL Overall: r = -0.27; p = 0.02). Spousal caregivers had a significantly lower DCI total score than dementia patients (p < 0.001). Dyadic coping was a significant mediator of the relationship between stress and QoL in spousal caregivers (z = 0.28; p = 0.02), but not in dementia patients. Likewise, relationship quality significantly mediated the relationship between stress and QoL in caregivers only (z = -2.41; p = 0.02). Conclusions: This study identified dyadic coping as a mediator on the relationship between stress and QoL in (caregiving) partners of dementia patients. In patients, however, we found a direct negative effect of stress on QoL. The findings suggest the importance of stress reducing and dyadic interventions for dementia patients and their partners, respectively.},
language = {en}
}
@article{HeisselPietrekRappetal.2019,
author = {Heissel, Andreas and Pietrek, Anou F. and Rapp, Michael A. and Heinzel, Stephan and Williams, Geoffrey},
title = {Perceived health care climate of older people attending an exercise program},
series = {Journal of aging and physical activity : JAPA ; the official journal of the International Society for Aging and Physical Activity},
volume = {28},
journal = {Journal of aging and physical activity : JAPA ; the official journal of the International Society for Aging and Physical Activity},
number = {2},
publisher = {Human Kinetics Publ.},
address = {Champaign},
issn = {1063-8652},
doi = {10.1123/japa.2018-0350},
pages = {276 -- 286},
year = {2019},
abstract = {The role of perceived need support from exercise professionals in improving mental health was examined in a sample of older adults, thereby validating the short Health Care Climate Questionnaire. A total of 491 older people (M = 72.68 years; SD = 5.47) attending a health exercise program participated in this study. Cronbach's alpha was found to be high (alpha = .90). Satisfaction with the exercise professional correlated moderately with the short Health Care Climate Questionnaire mean value (r = .38; p < .01). The mediator analyses yielded support for the self-determination theory process model in older adults by showing both basic need satisfaction and frustration as mediating variables between perceived autonomy support and depressive symptoms. The short Health Care Climate Questionnaire is an economical instrument for assessing basic need satisfaction provided by the exercise therapist from the participant's perspective. Furthermore, this cross-sectional study supported the link from coaching style to the satisfaction/frustration of basic psychological needs, which in turn, predicted mental health. Analyses of criterion validity suggest a revision of the construct by integrating need frustration.},
language = {en}
}
@article{GarbusowSchadSommeretal.2014,
author = {Garbusow, Maria and Schad, Daniel and Sommer, Christian and Juenger, Elisabeth and Sebold, Miriam and Friedel, Eva and Wendt, Jean and Kathmann, Norbert and Schlagenhauf, Florian and Zimmermann, Ulrich S. and Heinz, Andreas and Huys, Quentin J. M. and Rapp, Michael A.},
title = {Pavlovian-to-instrumental transfer in alcohol dependence: a pilot study},
series = {Neuropsychobiology : international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography},
volume = {70},
journal = {Neuropsychobiology : international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography},
number = {2},
publisher = {Karger},
address = {Basel},
issn = {0302-282X},
doi = {10.1159/000363507},
pages = {111 -- 121},
year = {2014},
abstract = {Background: Pavlovian processes are thought to play an important role in the development, maintenance and relapse of alcohol dependence, possibly by influencing and usurping ongoing thought and behavior. The influence of pavlovian stimuli on ongoing behavior is paradigmatically measured by pavlovian-to-instrumental transfer (PIT) tasks. These involve multiple stages and are complex. Whether increased PIT is involved in human alcohol dependence is uncertain. We therefore aimed to establish and validate a modified PIT paradigm that would be robust, consistent and tolerated by healthy controls as well as by patients suffering from alcohol dependence, and to explore whether alcohol dependence is associated with enhanced PIT. Methods: Thirty-two recently detoxified alcohol-dependent patients and 32 age- and gender-matched healthy controls performed a PIT task with instrumental go/no-go approach behaviors. The task involved both pavlovian stimuli associated with monetary rewards and losses, and images of drinks. Results: Both patients and healthy controls showed a robust and temporally stable PIT effect. Strengths of PIT effects to drug-related and monetary conditioned stimuli were highly correlated. Patients more frequently showed a PIT effect, and the effect was stronger in response to aversively conditioned CSs (conditioned suppression), but there was no group difference in response to appetitive CSs. Conclusion: The implementation of PIT has favorably robust properties in chronic alcohol-dependent patients and in healthy controls. It shows internal consistency between monetary and drug-related cues. The findings support an association of alcohol dependence with an increased propensity towards PIT.},
language = {en}
}
@article{SeboldSchadNebeetal.2016,
author = {Sebold, Miriam and Schad, Daniel and Nebe, Stephan and Garbusow, Maria and Juenger, Elisabeth and Kroemer, Nils B. and Kathmann, Norbert and Zimmermann, Ulrich S. and Smolka, Michael N. and Rapp, Michael A. and Heinz, Andreas and Huys, Quentin J. M.},
title = {Pavlovian-to-Instrumental Transfer Effects Rely Less on Model-based Reinforcement Learning},
series = {Journal of cognitive neuroscience},
volume = {28},
journal = {Journal of cognitive neuroscience},
publisher = {MIT Press},
address = {Cambridge},
issn = {0898-929X},
doi = {10.1162/jocn_a_00945},
pages = {985 -- 995},
year = {2016},
abstract = {Behavioral choice can be characterized along two axes. One axis distinguishes reflexive, model-free systems that slowly accumulate values through experience and a model-based system that uses knowledge to reason prospectively. The second axis distinguishes Pavlovian valuation of stimuli from instrumental valuation of actions or stimulus-action pairs. This results in four values and many possible interactions between them, with important consequences for accounts of individual variation. We here explored whether individual variation along one axis was related to individual variation along the other. Specifically, we asked whether individuals' balance between model-based and model-free learning was related to their tendency to show Pavlovian interferences with instrumental decisions. In two independent samples with a total of 243 participants, Pavlovian-instrumental transfer effects were negatively correlated with the strength of model-based reasoning in a two-step task. This suggests a potential common underlying substrate predisposing individuals to both have strong Pavlovian interference and be less model-based and provides a framework within which to interpret the observation of both effects in addiction.},
language = {en}
}
@article{GarbusowSchadSeboldetal.2016,
author = {Garbusow, Maria and Schad, Daniel and Sebold, Miriam and Friedel, Eva and Bernhardt, Nadine and Koch, Stefan P. and Steinacher, Bruno and Kathmann, Norbert and Geurts, Dirk E. M. and Sommer, Christian and Mueller, Dirk K. and Nebe, Stephan and Paul, Soeren and Wittchen, Hans-Ulrich and Zimmermann, Ulrich S. and Walter, Henrik and Smolka, Michael N. and Sterzer, Philipp and Rapp, Michael A. and Huys, Quentin J. M. and Schlagenhauf, Florian and Heinz, Andreas},
title = {Pavlovian-to-instrumental transfer effects in the nucleus accumbens relate to relapse in alcohol dependence},
series = {Addiction biology},
volume = {21},
journal = {Addiction biology},
publisher = {Wiley-Blackwell},
address = {Hoboken},
issn = {1355-6215},
doi = {10.1111/adb.12243},
pages = {719 -- 731},
year = {2016},
abstract = {In detoxified alcohol-dependent patients, alcohol-related stimuli can promote relapse. However, to date, the mechanisms by which contextual stimuli promote relapse have not been elucidated in detail. One hypothesis is that such contextual stimuli directly stimulate the motivation to drink via associated brain regions like the ventral striatum and thus promote alcohol seeking, intake and relapse. Pavlovian-to-Instrumental-Transfer (PIT) may be one of those behavioral phenomena contributing to relapse, capturing how Pavlovian conditioned (contextual) cues determine instrumental behavior (e.g. alcohol seeking and intake). We used a PIT paradigm during functional magnetic resonance imaging to examine the effects of classically conditioned Pavlovian stimuli on instrumental choices in n=31 detoxified patients diagnosed with alcohol dependence and n=24 healthy controls matched for age and gender. Patients were followed up over a period of 3 months. We observed that (1) there was a significant behavioral PIT effect for all participants, which was significantly more pronounced in alcohol-dependent patients; (2) PIT was significantly associated with blood oxygen level-dependent (BOLD) signals in the nucleus accumbens (NAcc) in subsequent relapsers only; and (3) PIT-related NAcc activation was associated with, and predictive of, critical outcomes (amount of alcohol intake and relapse during a 3 months follow-up period) in alcohol-dependent patients. These observations show for the first time that PIT-related BOLD signals, as a measure of the influence of Pavlovian cues on instrumental behavior, predict alcohol intake and relapse in alcohol dependence.},
language = {en}
}
@misc{GarbusowNebeSommeretal.2019,
author = {Garbusow, Maria and Nebe, Stephan and Sommer, Christian and Kuitunen-Paul, S{\"o}ren and Sebold, Miriam and Schad, Daniel and Friedel, Eva and Veer, Ilya M. and Wittchen, Hans-Ulrich and Rapp, Michael A. and Ripke, Stephan and Walter, Henrik and Huys, Quentin J. M. and Schlagenhauf, Florian and Smolka, Michael N. and Heinz, Andreas},
title = {Pavlovian-To-Instrumental Transfer and Alcohol Consumption in Young Male Social Drinkers},
series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
number = {841},
issn = {1866-8364},
doi = {10.25932/publishup-47328},
url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-473280},
pages = {14},
year = {2019},
abstract = {In animals and humans, behavior can be influenced by irrelevant stimuli, a phenomenon called Pavlovian-to-instrumental transfer (PIT). In subjects with substance use disorder, PIT is even enhanced with functional activation in the nucleus accumbens (NAcc) and amygdala. While we observed enhanced behavioral and neural PIT effects in alcohol-dependent subjects, we here aimed to determine whether behavioral PIT is enhanced in young men with high-risk compared to low-risk drinking and subsequently related functional activation in an a-priori region of interest encompassing the NAcc and amygdala and related to polygenic risk for alcohol consumption. A representative sample of 18-year old men (n = 1937) was contacted: 445 were screened, 209 assessed: resulting in 191 valid behavioral, 139 imaging and 157 genetic datasets. None of the subjects fulfilled criteria for alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-IV-TextRevision (DSM-IV-TR). We measured how instrumental responding for rewards was influenced by background Pavlovian conditioned stimuli predicting action-independent rewards and losses. Behavioral PIT was enhanced in high-compared to low-risk drinkers (b = 0.09, SE = 0.03, z = 2.7, p < 0.009). Across all subjects, we observed PIT-related neural blood oxygen level-dependent (BOLD) signal in the right amygdala (t = 3.25, p(SVC) = 0.04, x = 26, y = -6, z = -12), but not in NAcc. The strength of the behavioral PIT effect was positively correlated with polygenic risk for alcohol consumption (r(s) = 0.17, p = 0.032). We conclude that behavioral PIT and polygenic risk for alcohol consumption might be a biomarker for a subclinical phenotype of risky alcohol consumption, even if no drug-related stimulus is present. The association between behavioral PIT effects and the amygdala might point to habitual processes related to out PIT task. In non-dependent young social drinkers, the amygdala rather than the NAcc is activated during PIT; possible different involvement in association with disease trajectory should be investigated in future studies.},
language = {en}
}
@article{GarbusowNebeSommeretal.2019,
author = {Garbusow, Maria and Nebe, Stephan and Sommer, Christian and Kuitunen-Paul, S{\"o}ren and Sebold, Miriam and Schad, Daniel and Friedel, Eva and Veer, Ilya M. and Wittchen, Hans-Ulrich and Rapp, Michael A. and Ripke, Stephan and Walter, Henrik and Huys, Quentin J. M. and Schlagenhauf, Florian and Smolka, Michael N. and Heinz, Andreas},
title = {Pavlovian-To-Instrumental Transfer and Alcohol Consumption in Young Male Social Drinkers},
series = {Journal of Clinical Medicine},
volume = {8},
journal = {Journal of Clinical Medicine},
number = {8},
publisher = {MDPI},
address = {Basel},
issn = {2077-0383},
doi = {10.3390/jcm8081188},
pages = {14},
year = {2019},
abstract = {In animals and humans, behavior can be influenced by irrelevant stimuli, a phenomenon called Pavlovian-to-instrumental transfer (PIT). In subjects with substance use disorder, PIT is even enhanced with functional activation in the nucleus accumbens (NAcc) and amygdala. While we observed enhanced behavioral and neural PIT effects in alcohol-dependent subjects, we here aimed to determine whether behavioral PIT is enhanced in young men with high-risk compared to low-risk drinking and subsequently related functional activation in an a-priori region of interest encompassing the NAcc and amygdala and related to polygenic risk for alcohol consumption. A representative sample of 18-year old men (n = 1937) was contacted: 445 were screened, 209 assessed: resulting in 191 valid behavioral, 139 imaging and 157 genetic datasets. None of the subjects fulfilled criteria for alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-IV-TextRevision (DSM-IV-TR). We measured how instrumental responding for rewards was influenced by background Pavlovian conditioned stimuli predicting action-independent rewards and losses. Behavioral PIT was enhanced in high-compared to low-risk drinkers (b = 0.09, SE = 0.03, z = 2.7, p < 0.009). Across all subjects, we observed PIT-related neural blood oxygen level-dependent (BOLD) signal in the right amygdala (t = 3.25, p(SVC) = 0.04, x = 26, y = -6, z = -12), but not in NAcc. The strength of the behavioral PIT effect was positively correlated with polygenic risk for alcohol consumption (r(s) = 0.17, p = 0.032). We conclude that behavioral PIT and polygenic risk for alcohol consumption might be a biomarker for a subclinical phenotype of risky alcohol consumption, even if no drug-related stimulus is present. The association between behavioral PIT effects and the amygdala might point to habitual processes related to out PIT task. In non-dependent young social drinkers, the amygdala rather than the NAcc is activated during PIT; possible different involvement in association with disease trajectory should be investigated in future studies.},
language = {en}
}
@article{GarbusowEbrahimiRiemerschmidetal.2022,
author = {Garbusow, Maria and Ebrahimi, Claudia and Riemerschmid, Carlotta and Daldrup, Luisa and Rothkirch, Marcus and Chen, Ke and Chen, Hao and Belanger, Matthew J. and Hentschel, Angela and Smolka, Michael and Heinz, Andreas and Pilhatsch, Maximilan and Rapp, Michael A.},
title = {Pavlovian-to-instrumental transfer across mental disorders},
series = {Neuropsychobiology : international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography},
volume = {81},
journal = {Neuropsychobiology : international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography},
number = {5},
publisher = {Karger},
address = {Basel},
issn = {0302-282X},
doi = {10.1159/000525579},
pages = {418 -- 437},
year = {2022},
abstract = {A mechanism known as Pavlovian-to-instrumental transfer (PIT) describes a phenomenon by which the values of environmental cues acquired through Pavlovian conditioning can motivate instrumental behavior. PIT may be one basic mechanism of action control that can characterize mental disorders on a dimensional level beyond current classification systems. Therefore, we review human PIT studies investigating subclinical and clinical mental syndromes. The literature prevails an inhomogeneous picture concerning PIT. While enhanced PIT effects seem to be present in non-substance-related disorders, overweight people, and most studies with AUD patients, no altered PIT effects were reported in tobacco use disorder and obesity. Regarding AUD and relapsing alcohol-dependent patients, there is mixed evidence of enhanced or no PIT effects. Additionally, there is evidence for aberrant corticostriatal activation and genetic risk, e.g., in association with high-risk alcohol consumption and relapse after alcohol detoxification. In patients with anorexia nervosa, stronger PIT effects elicited by low caloric stimuli were associated with increased disease severity. In patients with depression, enhanced aversive PIT effects and a loss of action-specificity associated with poorer treatment outcomes were reported. Schizophrenic patients showed disrupted specific but intact general PIT effects. Patients with chronic back pain showed reduced PIT effects. We provide possible reasons to understand heterogeneity in PIT effects within and across mental disorders. Further, we strengthen the importance of reliable experimental tasks and provide test-retest data of a PIT task showing moderate to good reliability. Finally, we point toward stress as a possible underlying factor that may explain stronger PIT effects in mental disorders, as there is some evidence that stress per se interacts with the impact of environmental cues on behavior by selectively increasing cue-triggered wanting. To conclude, we discuss the results of the literature review in the light of Research Domain Criteria, suggesting future studies that comprehensively assess PIT across psychopathological dimensions.},
language = {en}
}
@misc{GarbusowSommerNebeetal.2018,
author = {Garbusow, Maria and Sommer, C. and Nebe, S. and Sebold, Miriam and Kuitunen-Paul, S{\"o}ren and Wittchen, H. U. and Smolka, M. and Zimmermann, U. and Rapp, Michael A. and Huys, Q. and Schlagenhauf, Florian and Heinz, A.},
title = {Pavlovian-instrumental transfer in the course of alcohol use disorder},
series = {European psychiatry : the journal of the Association of European Psychiatrists},
volume = {48},
journal = {European psychiatry : the journal of the Association of European Psychiatrists},
publisher = {Elsevier},
address = {ISSY-LES-MOULINEAUX},
issn = {0924-9338},
pages = {S546 -- S546},
year = {2018},
abstract = {Background: Pavlovian processes are thought to play an important role in the development, maintenance and relapse of alcohol dependence, possibly by influencing and usurping on- going thought and behavior. The influence of Pavlovian stimuli on on-going behavior is paradigmatically measured by Pavlovian-to-instrumental-transfer (PIT) tasks. These involve multiple stages and are complex. Whether increased PIT is involved in human alcohol dependence is uncertain. We therefore aimed to establish and validate a modified PIT paradigm that would be robust, consistent, and tolerated by healthy controls as well as by patients suffering from alcohol dependence, and to explore whether alcohol dependence is associated with enhanced Pavlovian-Instrumental transfer. Methods: 32 recently detoxified alcohol-dependent patients and 32 age and gender matched healthy controls performed a PIT task with instrumental go/no-go approach behaviours. The task involved both Pavlovian stimuli associated with monetary rewards and losses, and images of drinks. Results: Both patients and healthy controls showed a robust and temporally stable PIT effect. Strengths of PIT effects to drug-related and monetary conditioned stimuli were highly correlated. Patients more frequently showed a PIT effect and the effect was stronger in response to aversively conditioned CSs (conditioned suppression), but there was no group difference in response to appetitive CSs. Conclusion: The implementation of PIT has favorably robust properties in chronic alcohol- dependent patients and in healthy controls. It shows internal consistency between monetary and drug-related cues. The findings support an association of alcohol dependence with an increased propensity towards PIT.},
language = {en}
}
@article{MellJacobFuhretal.2017,
author = {Mell, Thomas and Jacob, Louis and Fuhr, Ida and Dick, Sandra and Rapp, Michael A. and Kostev, Karel},
title = {Patterns of benzodiazepine prescribing by neuropsychiatrists and general practitioners for elderly patients in Germany in 2014},
series = {International journal of clinical pharmacology and therapeutics},
volume = {55},
journal = {International journal of clinical pharmacology and therapeutics},
publisher = {Dustri-Verlag Dr. Karl Feistle},
address = {Deisenhofen-M{\"u}nchen},
issn = {0946-1965},
doi = {10.5414/CP202904},
pages = {466 -- 471},
year = {2017},
abstract = {Background: The patterns of benzodiazepine prescriptions in older adults are of general and scientific interest as they are not yet well understood. The aim of this study was to compare the prescription patterns of benzodiazepines in elderly people in Germany to determine the share or proportion treated by general practitioners (GP) and neuropsychiatrists (NP). Methods: This study included 31,268 and 6,603 patients between the ages of 65 and 100 with at least one benzodiazepine prescription in 2014 from GP and NP, respectively. Demographic data included age, gender, and type of health insurance coverage. The share of elderly people with benzodiazepine prescriptions was estimated in different age and disease groups for both GP and NP patients. The share of the six most commonly prescribed drugs was also calculated for each type of practice. Results: The share of people taking benzodiazepines prescribed by GP increased from 3.2\% in patients aged between 65 and 69 years to 8.6\% in patients aged between 90 and 100 years, whereas this share increased from 5.4\% to 7.1\% in those seen by NP. Benzodiazepines were frequently used by patients suffering from sleep disorders (GP: 33.9\%; NP: 5.5\%), depression (GP: 17.9\%; NP: 29.8\%), and anxiety disorders (GP: 14.5\%; NP: 22.8\%). Lorazepam (30.3\%), oxazepam (24.7\%), and bromazepam (24.3\%) were the three most commonly prescribed drugs for GP patients. In contrast, lorazepam (60.4\%), diazepam (14.8\%), and oxazepam (11.2\%) were those more frequently prescribed to NP patients. Conclusion: Prescription patterns of benzodiazepine in the elderly varied widely between GP and NP.},
language = {en}
}