@article{HuettlHettrichRiedeletal.2015, author = {H{\"u}ttl, Christine and Hettrich, Cornelia and Riedel, Melanie and Henklein, Petra and Rawel, Harshadrai Manilal and Bier, Frank Fabian}, title = {Development of Peptidyl Lysine Dendrons: 1,3-Dipolar Cycloaddition for Peptide Coupling and Antibody Recognition}, series = {Chemical biology \& drug design}, volume = {85}, journal = {Chemical biology \& drug design}, number = {5}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {1747-0277}, doi = {10.1111/cbdd.12444}, pages = {565 -- 573}, year = {2015}, abstract = {A straightforward synthesis strategy to multimerize a peptide mimotopes for antibody B13-DE1 recognition is described based on lysine dendrons as multivalent scaffolds. Lysine dendrons that possess N-terminal alkyne residues at the periphery were quantitative functionalized with azido peptides using click chemistry. The solid-phase peptide synthesis (SPPS) allows preparing the peptide dendron in high purity and establishing the possibility of automation. The presented peptide dendron is a promising candidate as multivalent ligand and was used for antibody B13-DE1 recognition. The binding affinity increases with higher dendron generation without loss of specificity. The analysis of biospecific interaction between the synthesized peptide dendron and the antibody was done via surface plasmon resonance (SPR) technique. The presented results show a promising tool for investigations of antigen-antibody reactions.}, language = {en} } @article{AnklamBehlerDingermannetal.2013, author = {Anklam, Elke and Behler, J{\"o}rg and Dingermann, Theodor and Elsinghorst, Paul and Fischer, Jochen and Esselen, Melanie and Foerster, Christian and Fr{\"o}hlich, Daniel and Goedel, Werner Andreas and Gregory, Peter and Grimme, Stefan and Hackenberger, Christian and Hansmann, Max and Heppekausen, Johannes and Hasenstab-Riedel, Sebastian and Kirchhoff, Erhard and Kratz, Karl-Ludwig and Krausz, Ferenc and Linker, Torsten and List, Benjamin and Ray, Kallol and Salzer, Reiner and Schubert, Ulrich and Schueth, Ferdi and Schwarz, Helmut and Schwietzke, Uta and Strey, Reinhard and Stumpf, Thorsten and Vaagt, Franziska and Volodkin, Dmitry and Wilke, Guenther and Zass, Engelbert and Zemb, Thomas}, title = {Awards}, series = {Nachrichten aus der Chemie : Zeitschrift der Gesellschaft Deutscher Chemiker}, volume = {61}, journal = {Nachrichten aus der Chemie : Zeitschrift der Gesellschaft Deutscher Chemiker}, number = {11}, publisher = {Ges. Dt. Chemiker}, address = {Frankfurt, Main}, issn = {1439-9598}, doi = {10.1002/nadc.201390372}, pages = {1145 -- 1148}, year = {2013}, language = {de} }