@article{ActisAgnettaAharonianetal.2011, author = {Actis, M. and Agnetta, G. and Aharonian, Felix A. and Akhperjanian, A. G. and Aleksic, J. and Aliu, E. and Allan, D. and Allekotte, I. and Antico, F. and Antonelli, L. A. and Antoranz, P. and Aravantinos, A. and Arlen, T. and Arnaldi, H. and Artmann, S. and Asano, K. and Asorey, H. G. and Baehr, J. and Bais, A. and Baixeras, C. and Bajtlik, S. and Balis, D. and Bamba, A. and Barbier, C. and Barcelo, M. and Barnacka, Anna and Barnstedt, J{\"u}rgen and de Almeida, U. Barres and Barrio, J. A. and Basso, S. and Bastieri, D. and Bauer, C. and Becerra Gonzalez, J. and Becherini, Yvonne and Bechtol, K. C. and Becker, J. and Beckmann, Volker and Bednarek, W. and Behera, B. and Beilicke, M. and Belluso, M. and Benallou, M. and Benbow, W. and Berdugo, J. and Berger, K. and Bernardino, T. and Bernl{\"o}hr, K. and Biland, A. and Billotta, S. and Bird, T. and Birsin, E. and Bissaldi, E. and Blake, S. and Blanch Bigas, O. and Bobkov, A. A. and Bogacz, L. and Bogdan, M. and Boisson, Catherine and Boix Gargallo, J. and Bolmont, J. and Bonanno, G. and Bonardi, A. and Bonev, T. and Borkowski, Janett and Botner, O. and Bottani, A. and Bourgeat, M. and Boutonnet, C. and Bouvier, A. and Brau-Nogue, S. and Braun, I. and Bretz, T. and Briggs, M. S. and Brun, Pierre and Brunetti, L. and Buckley, H. and Bugaev, V. and Buehler, R. and Bulik, Tomasz and Busetto, G. and Buson, S. and Byrum, K. and Cailles, M. and Cameron, R. A. and Canestrari, R. and Cantu, S. and Carmona, E. and Carosi, A. and Carr, John and Carton, P. H. and Casiraghi, M. and Castarede, H. and Catalano, O. and Cavazzani, S. and Cazaux, S. and Cerruti, B. and Cerruti, M. and Chadwick, M. and Chiang, J. and Chikawa, M. and Cieslar, M. and Ciesielska, M. and Cillis, A. N. and Clerc, C. and Colin, P. and Colome, J. and Compin, M. and Conconi, P. and Connaughton, V. and Conrad, Jan and Contreras, J. L. and Coppi, P. and Corlier, M. and Corona, P. and Corpace, O. and Corti, D. and Cortina, J. and Costantini, H. and Cotter, G. and Courty, B. and Couturier, S. and Covino, S. and Croston, J. and Cusumano, G. and Daniel, M. K. and Dazzi, F. and Deangelis, A. and de Cea del Pozo, E. and Dal Pino, E. M. de Gouveia and de Jager, O. and de la Calle Perez, I. and De La Vega, G. and De Lotto, B. and de Naurois, M. and Wilhelmi, E. de Ona and de Souza, V. and Decerprit, B. and Deil, C. and Delagnes, E. and Deleglise, G. and Delgado, C. and Dettlaff, T. and Di Paolo, A. and Di Pierro, F. and Diaz, C. and Dick, J. and Dickinson, H. and Digel, S. W. and Dimitrov, D. and Disset, G. and Djannati-Ata{\"i}, A. and Doert, M. and Domainko, W. and Dorner, D. and Doro, M. and Dournaux, J. -L. and Dravins, D. and Drury, L. and Dubois, F. and Dubois, R. and Dubus, G. and Dufour, C. and Durand, D. and Dyks, J. and Dyrda, M. and Edy, E. and Egberts, Kathrin and Eleftheriadis, C. and Elles, S. and Emmanoulopoulos, D. and Enomoto, R. and Ernenwein, J. -P. and Errando, M. and Etchegoyen, A. and Falcone, A. D. and Farakos, K. and Farnier, C. and Federici, S. and Feinstein, F. and Ferenc, D. and Fillin-Martino, E. and Fink, D. and Finley, C. and Finley, J. P. and Firpo, R. and Florin, D. and Foehr, C. and Fokitis, E. and Font, Ll. and Fontaine, G. and Fontana, A. and Foerster, A. and Fortson, L. and Fouque, N. and Fransson, C. and Fraser, G. W. and Fresnillo, L. and Fruck, C. and Fujita, Y. and Fukazawa, Y. and Funk, S. and Gaebele, W. and Gabici, S. and Gadola, A. and Galante, N. and Gallant, Y. and Garcia, B. and Garcia Lopez, R. J. and Garrido, D. and Garrido, L. and Gascon, D. and Gasq, C. and Gaug, M. and Gaweda, J. and Geffroy, N. and Ghag, C. and Ghedina, A. and Ghigo, M. and Gianakaki, E. and Giarrusso, S. and Giavitto, G. and Giebels, B. and Giro, E. and Giubilato, P. and Glanzman, T. and Glicenstein, J. -F. and Gochna, M. and Golev, V. and Gomez Berisso, M. and Gonzalez, A. and Gonzalez, F. and Granena, F. and Graciani, R. and Granot, J. and Gredig, R. and Green, A. and Greenshaw, T. and Grimm, O. and Grube, J. and Grudzinska, M. and Grygorczuk, J. and Guarino, V. and Guglielmi, L. and Guilloux, F. and Gunji, S. and Gyuk, G. and Hadasch, D. and Haefner, D. and Hagiwara, R. and Hahn, J. and Hallgren, A. and Hara, S. and Hardcastle, M. J. and Hassan, T. and Haubold, T. and Hauser, M. and Hayashida, M. and Heller, R. and Henri, G. and Hermann, G. and Herrero, A. and Hinton, James Anthony and Hoffmann, D. and Hofmann, W. and Hofverberg, P. and Horns, D. and Hrupec, D. and Huan, H. and Huber, B. and Huet, J. -M. and Hughes, G. and Hultquist, K. and Humensky, T. B. and Huppert, J. -F. and Ibarra, A. and Illa, J. M. and Ingjald, J. and Inoue, S. and Inoue, Y. and Ioka, K. and Jablonski, C. and Jacholkowska, A. and Janiak, M. and Jean, P. and Jensen, H. and Jogler, T. and Jung, I. and Kaaret, P. and Kabuki, S. and Kakuwa, J. and Kalkuhl, C. and Kankanyan, R. and Kapala, M. and Karastergiou, A. and Karczewski, M. and Karkar, S. and Karlsson, N. and Kasperek, J. and Katagiri, H. and Katarzynski, K. and Kawanaka, N. and Kedziora, B. and Kendziorra, E. and Khelifi, B. and Kieda, D. and Kifune, T. and Kihm, T. and Klepser, S. and Kluzniak, W. and Knapp, J. and Knappy, A. 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C. and Maccarone, T. and Maier, G. and Majumdar, P. and Maltezos, S. and Malkiewicz, P. and Mana, C. and Manalaysay, A. and Maneva, G. and Mangano, A. and Manigot, P. and Marin, J. and Mariotti, M. and Markoff, S. and Martinez, G. and Martinez, M. and Mastichiadis, A. and Matsumoto, H. and Mattiazzo, S. and Mazin, D. and McComb, T. J. L. and McCubbin, N. and McHardy, I. and Medina, C. and Melkumyan, D. and Mendes, A. and Mertsch, P. and Meucci, M. and Michalowski, J. and Micolon, P. and Mineo, T. and Mirabal, N. and Mirabel, F. and Miranda, J. M. and Mirzoyan, R. and Mizuno, T. and Moal, B. and Moderski, R. and Molinari, E. and Monteiro, I. and Moralejo, A. and Morello, C. and Mori, K. and Motta, G. and Mottez, F. and Moulin, E. and Mukherjee, R. and Munar, P. and Muraishi, H. and Murase, K. and Murphy, A. Stj. and Nagataki, S. and Naito, T. and Nakamori, T. and Nakayama, K. and Naumann, C. L. and Naumann, D. and Nayman, P. and Nedbal, D. and Niedzwiecki, A. and Niemiec, J. and Nikolaidis, A. and Nishijima, K. and Nolan, S. J. and Nowak, N. and O'Brien, P. T. and Ochoa, I. and Ohira, Y. and Ohishi, M. and Ohka, H. and Okumura, A. and Olivetto, C. and Ong, R. A. and Orito, R. and Orr, M. and Osborne, J. P. and Ostrowski, M. and Otero, L. and Otte, A. N. and Ovcharov, E. and Oya, I. and Ozieblo, A. and Paiano, S. and Pallota, J. and Panazol, J. L. and Paneque, D. and Panter, M. and Paoletti, R. and Papyan, G. and Paredes, J. M. and Pareschi, G. and Parsons, R. D. and Arribas, M. Paz and Pedaletti, G. and Pepato, A. and Persic, M. and Petrucci, P. O. and Peyaud, B. and Piechocki, W. and Pita, S. and Pivato, G. and Platos, L. and Platzer, R. and Pogosyan, L. and Pohl, Martin and Pojmanski, G. and Ponz, J. 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M. and Sanuy, A. and Sapozhnikov, L. and Sarkar, S. and Scalzotto, V. and Scapin, V. and Scarcioffolo, M. and Schanz, T. and Schlenstedt, S. and Schlickeiser, R. and Schmidt, T. and Schmoll, J. and Schroedter, M. and Schultz, C. and Schultze, J. and Schulz, A. and Schwanke, U. and Schwarzburg, S. and Schweizer, T. and Seiradakis, J. and Selmane, S. and Seweryn, K. and Shayduk, M. and Shellard, R. C. and Shibata, T. and Sikora, M. and Silk, J. and Sillanpaa, A. and Sitarek, J. and Skole, C. and Smith, N. and Sobczynska, D. and Sofo Haro, M. and Sol, H. and Spanier, F. and Spiga, D. and Spyrou, S. and Stamatescu, V. and Stamerra, A. and Starling, R. L. C. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steiner, S. and Stergioulas, N. and Sternberger, R. and Stinzing, F. and Stodulski, M. and Straumann, U. and Suarez, A. and Suchenek, M. and Sugawara, R. and Sulanke, K. H. and Sun, S. and Supanitsky, A. D. and Sutcliffe, P. and Szanecki, M. and Szepieniec, T. and Szostek, A. and Szymkowiak, A. and Tagliaferri, G. and Tajima, H. and Takahashi, H. and Takahashi, K. and Takalo, L. and Takami, H. and Talbot, R. G. and Tam, P. H. and Tanaka, M. and Tanimori, T. and Tavani, M. and Tavernet, J. -P. and Tchernin, C. and Tejedor, L. A. and Telezhinsky, Igor O. and Temnikov, P. and Tenzer, C. and Terada, Y. and Terrier, R. and Teshima, M. and Testa, V. and Tibaldo, L. and Tibolla, O. and Tluczykont, M. and Peixoto, C. J. Todero and Tokanai, F. and Tokarz, M. and Toma, K. and Torres, D. F. and Tosti, G. and Totani, T. and Toussenel, F. and Vallania, P. and Vallejo, G. and van der Walt, J. and van Eldik, C. and Vandenbroucke, J. and Vankov, H. and Vasileiadis, G. and Vassiliev, V. V. and Vegas, I. and Venter, L. and Vercellone, S. and Veyssiere, C. and Vialle, J. P. and Videla, M. and Vincent, P. and Vink, J. and Vlahakis, N. and Vlahos, L. and Vogler, P. and Vollhardt, A. and Volpe, F. and Von Gunten, H. P. and Vorobiov, S. and Wagner, S. and Wagner, R. M. and Wagner, B. and Wakely, S. P. and Walter, P. and Walter, R. and Warwick, R. and Wawer, P. and Wawrzaszek, R. and Webb, N. and Wegner, P. and Weinstein, A. and Weitzel, Q. and Welsing, R. and Wetteskind, H. and White, R. and Wierzcholska, A. and Wilkinson, M. I. and Williams, D. A. and Winde, M. and Wischnewski, R. and Wisniewski, L. and Wolczko, A. and Wood, M. and Xiong, Q. and Yamamoto, T. and Yamaoka, K. and Yamazaki, R. and Yanagita, S. and Yoffo, B. and Yonetani, M. and Yoshida, A. and Yoshida, T. and Yoshikoshi, T. and Zabalza, V. and Zagdanski, A. and Zajczyk, A. and Zdziarski, A. and Zech, Alraune and Zietara, K. and Ziolkowski, P. and Zitelli, V. and Zychowski, P.}, title = {Design concepts for the Cherenkov Telescope Array CTA an advanced facility for ground-based high-energy gamma-ray astronomy}, series = {Experimental astronomy : an international journal on astronomical instrumentation and data analysis}, volume = {32}, journal = {Experimental astronomy : an international journal on astronomical instrumentation and data analysis}, number = {3}, publisher = {Springer}, address = {Dordrecht}, organization = {CTA Consortium}, issn = {0922-6435}, doi = {10.1007/s10686-011-9247-0}, pages = {193 -- 316}, year = {2011}, abstract = {Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA.}, language = {en} } @article{WittBuchmannBlomeyeretal.2011, author = {Witt, Stephanie H. and Buchmann, Arlette F. and Blomeyer, Dorothea and Nieratschker, Vanessa and Treutlein, Jens and Esser, G{\"u}nter and Schmidt, Martin H. and Bidlingmaier, Martin and Wiedemann, Klaus and Rietschel, Marcella and Laucht, Manfred and Wuest, Stefan and Zimmermann, Ulrich S.}, title = {An interaction between a neuropeptide Y gene polymorphism and early adversity modulates endocrine stress responses}, series = {Psychoneuroendocrinology}, volume = {36}, journal = {Psychoneuroendocrinology}, number = {7}, publisher = {Elsevier}, address = {Oxford}, issn = {0306-4530}, doi = {10.1016/j.psyneuen.2010.12.015}, pages = {1010 -- 1020}, year = {2011}, abstract = {Interindividual variability in the regulation of the human stress system accounts for a part of the individual's liability to stress-related diseases. These differences are influenced by environmental and genetic factors. Early childhood adversity is a well-studied environmental factor affecting an individual's stress response which has been shown to be modulated by gene environment interaction (GxE). Neuropeptide Y (NPY) plays a role in stress regulation and genetic variation in NPY may influence stress responses. In this study, we analyzed the association of a common variant in the NPY gene promoter, rs16147, with cortisol and ACTH responses to acute psychosocial stress in young adults from the Mannheim Study of Children at Risk (MARS), an ongoing epidemiological cohort study following the outcome of early adversity from birth into adulthood. We found evidence of a GxE interaction between rs16147 and early adversity significantly affecting HPA axis responses to acute psychosocial stress. These findings suggest that the neurobiological mechanisms linking early adverse experience and later neuroendocrine stress regulation are modulated by a gene variant whose functional relevance is documented by increasing convergent evidence from in vitro, animal and human studies.}, language = {en} } @article{HoltmannBuchmannEsseretal.2011, author = {Holtmann, Martin and Buchmann, Arlette F. and Esser, G{\"u}nter and Schmidt, Martin H. and Banaschewski, Tobias and Laucht, Manfred}, title = {The child behavior checklist-dysregulation profile predicts substance use, suicidality, and functional impairment : a longitudinal analysis}, year = {2011}, abstract = {Recent studies have identified a Child Behavior Checklist profile that characterizes children with severe affective and behavioral dysregulation (CBCL-dysregulation profile, CBCL-DP). In two recent longitudinal studies the CBCL-DP in childhood was associated with heightened rates of comorbid psychiatric disorders, among them bipolar disorder, an increased risk for suicidality, and marked psychosocial impairment at young-adult follow-up. This is the first study outside the US that examines the longitudinal course of the CBCL-DP. Methods: We studied the diagnostic and functional trajectories and the predictive utility of the CBCL-DP in the Mannheim Study of Children at Risk, an epidemiological cohort study on the outcome of early risk factors from birth into adulthood. A total of 325 young adults (151 males, 174 females) participated in the 19-year assessment. Results: Young adults with a higher CBCL-DP score in childhood were at increased risk for substance use disorders, suicidality and poorer overall functioning at age 19, even after adjustment for parental education, family income, impairment and psychiatric disorders at baseline. Childhood dysregulation was not related to bipolar disorder in young adulthood. The CBCL-DP was neither a precursor of a specific pattern of comorbidity nor of comorbidity in general. Conclusions: Children with high CBCL-DP values are at risk for later severe, psychiatric symptomatology. The different developmental trajectories suggest that the CBCL-DP is not simply an early manifestation of a single disease process but might rather be an early developmental risk marker of a persisting deficit of self-regulation of affect and behavior.}, language = {en} } @article{HoltmannBuchmannEsseretal.2011, author = {Holtmann, Martin and Buchmann, Arlette F. and Esser, G{\"u}nter and Schmidt, Martin H. and Banaschewski, Tobias and Laucht, Manfred}, title = {The child behavior checklist-dysregulation profile predicts substance use, suicidality, and functional impairment a longitudinal analysis}, series = {The journal of child psychology and psychiatry}, volume = {52}, journal = {The journal of child psychology and psychiatry}, number = {2}, publisher = {Wiley-Blackwell}, address = {Malden}, issn = {0021-9630}, doi = {10.1111/j.1469-7610.2010.02309.x}, pages = {139 -- 147}, year = {2011}, abstract = {Background: Recent studies have identified a Child Behavior Checklist profile that characterizes children with severe affective and behavioral dysregulation (CBCL-dysregulation profile, CBCL-DP). In two recent longitudinal studies the CBCL-DP in childhood was associated with heightened rates of comorbid psychiatric disorders, among them bipolar disorder, an increased risk for suicidality, and marked psychosocial impairment at young-adult follow-up. This is the first study outside the US that examines the longitudinal course of the CBCL-DP. Methods: We studied the diagnostic and functional trajectories and the predictive utility of the CBCL-DP in the Mannheim Study of Children at Risk, an epidemiological cohort study on the outcome of early risk factors from birth into adulthood. A total of 325 young adults (151 males, 174 females) participated in the 19-year assessment. Results: Young adults with a higher CBCL-DP score in childhood were at increased risk for substance use disorders, suicidality and poorer overall functioning at age 19, even after adjustment for parental education, family income, impairment and psychiatric disorders at baseline. Childhood dysregulation was not related to bipolar disorder in young adulthood. The CBCL-DP was neither a precursor of a specific pattern of comorbidity nor of comorbidity in general. Conclusions: Children with high CBCL-DP values are at risk for later severe, psychiatric symptomatology. The different developmental trajectories suggest that the CBCL-DP is not simply an early manifestation of a single disease process but might rather be an early developmental risk marker of a persisting deficit of self-regulation of affect and behavior.}, language = {en} } @article{BlomeyerBuchmannSchmidetal.2011, author = {Blomeyer, Dorothea and Buchmann, Arlette F. and Schmid, Brigitte and Jennen-Steinmetz, Christine and Schmidt, Martin H. and Banaschewski, Tobias and Laucht, Manfred}, title = {Age at first drink moderates the impact of current stressful life events on drinking behavior in young adults}, series = {Alcoholism : clinical and experimental research ; the official journal of the American Medical Society on Alcoholism and the Research Society on Alcoholism}, volume = {35}, journal = {Alcoholism : clinical and experimental research ; the official journal of the American Medical Society on Alcoholism and the Research Society on Alcoholism}, number = {6}, publisher = {Wiley-Blackwell}, address = {Malden}, issn = {0145-6008}, doi = {10.1111/j.1530-0277.2011.01447.x}, pages = {1142 -- 1148}, year = {2011}, abstract = {Background: Recent evidence from animal experiments and studies in humans suggests that early age at first drink (AFD) may lead to higher stress-induced drinking. The present study aimed to extend these findings by examining whether AFD interacted with stressful life events (SLE) and/or with daily hassles regarding the impact on drinking patterns among young adults. Method: In 306 participants of an epidemiological cohort study, AFD was assessed together with SLE during the past 3 years, daily hassles in the last month, and drinking behavior at age 22. As outcome variables, 2 variables were derived, reflecting different aspects of alcohol use: the amount of alcohol consumed in the last month and the drinking frequency, indicated by the number of drinking days in the last month. Results: Linear regression models revealed an interaction effect between the continuous measures of AFD and SLE on the amount of alcohol consumed. The earlier young adults had their first alcoholic drink and the higher the levels of SLE they were exposed to, the disproportionately more alcohol they consumed. Drinking frequency was not affected by an interaction of these variables, while daily hassles and their interaction with AFD were unrelated to drinking behavior. Conclusions: These findings highlight the importance of early age at drinking onset as a risk factor for later heavy drinking under high load of SLE. Prevention programs should aim to raise age at first contact with alcohol. Additionally, support in stressful life situations and the acquisition of effective coping strategies might prevent heavy drinking in those with earlier drinking onset.}, language = {en} } @article{PitzerJennenSteinmetzEsseretal.2011, author = {Pitzer, Martina and Jennen-Steinmetz, Christine and Esser, G{\"u}nter and Schmidt, Martin H. and Laucht, Manfred}, title = {Prediction of preadolescent depressive symptoms from child temperament, maternal distress, and gender results of a prospective, longitudinal study}, series = {Journal of developmental and behavioral pediatrics}, volume = {32}, journal = {Journal of developmental and behavioral pediatrics}, number = {1}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, issn = {0196-206X}, doi = {10.1097/DBP.0b013e3181f4a474}, pages = {18 -- 26}, year = {2011}, abstract = {Objective: The delineation of developmental pathways to juvenile depressive symptoms is of major clinical interest because these are known to be predictive for adult mood disorders and for a range of other mental health problems. This study investigates the impact of child temperament and early maternal distress, both of which are known to influence children's emotional development, on preadolescent depression. Methods: In a prospective, longitudinal at-risk sample (163 boys, 178 girls), we assessed temperament at the age of 3 months and at 2 years, 4.5 years, and 8 years, respectively, and chronic maternal distress during infancy. Hierarchical linear regression analysis was used to investigate the prediction of depressive symptoms at the age of 11 years measured by the Child Depression Inventory. In addition, we controlled for psychosocial and obstetric perinatal risks and gender. Results: Psychosocial risks and self-control temperament made significant independent contributions to preadolescent depression, whereas fearful, difficult temperament and obstetric risks were unrelated to depressive outcome. Interestingly, a clear gender difference emerged with a significant prediction from maternal distress only in girls. Conclusions: Our data extend previous findings of a concurrent association between regulative temperament and juvenile depression to a predictive view. Furthermore, the results point toward gender-specific pathways to preadolescent depression and support earlier findings indicating that subclinical maternal distress may exert as detrimental effects on child development as clinical depression.}, language = {en} } @article{PitzerJennenSteinmetzEsseretal.2011, author = {Pitzer, Martina and Jennen-Steinmetz, Christine and Esser, G{\"u}nter and Schmidt, Martin H. and Laucht, Manfred}, title = {Differential susceptibility to environmental influences the role of early temperament and parenting in the development of externalizing problems}, series = {Comprehensive psychiatry : official journal of the American Psychopathological Association}, volume = {52}, journal = {Comprehensive psychiatry : official journal of the American Psychopathological Association}, number = {6}, publisher = {Elsevier}, address = {Philadelphia}, issn = {0010-440X}, doi = {10.1016/j.comppsych.2010.10.017}, pages = {650 -- 658}, year = {2011}, abstract = {Objective: A difficult or undercontrolled temperament, as well as harsh parental discipline or a lack of warmth, has long been regarded as risk factors for the development of externalizing problems. In addition, it has been suggested that children with difficult temperament are especially susceptible to rearing influences. We investigated the impact of early temperament and parenting and their interactions on externalizing behavior at school age. Methods: Participants were 148 boys and 160 girls from a prospective longitudinal study on a high-risk sample. At ages 3 months and 2 years, temperament was assessed by a highly structured parent interview and standardized behavioral observations. Maternal parenting was assessed by videotaped behavioral observation and a parent questionnaire. Externalizing problems at age 8 years were measured by the Child Behavior Checklist. Results: Using hierarchical linear regression analyses, we found that externalizing problems were predicted by psychosocial adversity and poor self-control, whereas no main effect for restrictive parenting or maternal empathy was found. Fearful-inhibited boys were positively affected by empathic and sensitive parenting, whereas girls who were low in self-control and/or fearful developed less externalizing problems with restrictive parenting. Conclusion: Our results partly support the differential susceptibility hypothesis. In addition, they point toward gender-specific pathways in the development of externalizing problems.}, language = {en} } @article{SchmidBlomeyerBuchmannetal.2011, author = {Schmid, Brigitte and Blomeyer, Dorothea and Buchmann, Arlette F. and Trautmann-Villalba, Patricia and Zimmermann, Ulrich S. and Schmidt, Martin H. and Esser, G{\"u}nter and Banaschewski, Tobias and Laucht, Manfred}, title = {Quality of early mother-child interaction associated with depressive psychopathology in the offspring - a prospective study from infancy to adulthood}, series = {Journal of psychiatric research}, volume = {45}, journal = {Journal of psychiatric research}, number = {10}, publisher = {Elsevier}, address = {Oxford}, issn = {0022-3956}, doi = {10.1016/j.jpsychires.2011.05.010}, pages = {1387 -- 1394}, year = {2011}, abstract = {Evidence from animal research has revealed that less maternal care results in disturbed emotionality in the offspring. In the present study, the long-term impact of maternal responsiveness and stimulation during early mother child interaction on depressive psychopathology was examined until adulthood. Data are from an epidemiological cohort study of the long-term outcome of early risk factors assessed at birth. At age 3 months, mothers and infants were videotaped during a nursing and playing situation. Maternal responsiveness and stimulation as well as infant responsiveness were evaluated by trained raters. At age 19 years, 314 participants (145 males, 169 females) were characterized on measures of depression through interview and questionnaire. In addition, measures of depression and anxiety were available from assessments in childhood. Results indicated that less maternal stimulation during early interaction was associated with a higher risk of depression in the offspring until the age of 19 years. In addition, children of less stimulating mothers showed more depressive symptoms at age 19 years and displayed more anxiety and depressive symptoms between the ages of 4.5 and 15 years. In contrast, maternal responsiveness was unrelated to children's outcome. In accordance with findings from animal research, the present study provides first longitudinal evidence in humans of a continuous and long-term influence of early maternal interaction behavior on the offspring's psychological adjustment until adulthood. The results suggest that the amount of maternally initiated contact behavior in a very early developmental stage may be crucial for children's mental health, regardless of child and maternal responsiveness.}, language = {en} }