@article{LetzelSynstadEijsinketal.1999,
  author    = {Letzel, Matthias C. and Synstad, Bjoenar and Eijsink, Vincent G. H. and Peter-Katalinic, Jasna and Peter, Martin G.},
  title     = {Libraries of chito-oligosaccharides of mixed acetylation patterns and their interactions with chitinases},
  isbn      = {3-9806494-5-8},
  year      = {1999},
  language  = {en}
}
@article{YenesewTwinomuhweziKiremireetal.2009,
  author    = {Yenesew, Abiy and Twinomuhwezi, Hannington and Kiremire, Bernard T. and Mbugua, Martin N. and Gitu, Peter M. and Heydenreich, Matthias and Peter, Martin G.},
  title     = {8-Methoxyneorautenol and radical scavenging flavonoids from Erythrina abyssinica},
  issn      = {1011-3924},
  year      = {2009},
  abstract  = {A new pterocarpan (named 8-methoxyneorautenol) was isolated from the acetone ext. of the root bark of Erythrina abyssinica. In addn., the known isoflavonoid derivs. eryvarin L, erycristagallin and shinpterocarpin were identified for the first time from the roots of this plant. The structures were detd. on the basis of spectroscopic evidence. The new compd. showed selective antimicrobial activity against Trichophyton mentagrophytes. The acetone ext. of the root bark of E. abyssinica showed radical scavenging activity towards 2,2-diphenyl-1-picrylhydrazyl radical (DPPH). The pterocarpenes, 3-hydroxy-9-methoxy-10-(3,3-dimethylallyl)pterocarpene and erycristagallin, were the most active constituents of the roots of this plant and showing dose-dependent activities similar to that of the std. quercetin. [on SciFinder (R)]},
  language  = {en}
}
@misc{PeterBoldtNiedersteinetal.1990,
  author    = {Peter, Martin G. and Boldt, Peter C. and Niederstein, Yvonne and Peter-Katalinić, Jasna},
  title     = {Synthesen von Galactose-Cluster-haltigen Steroid-Derivaten},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-16783},
  year      = {1990},
  abstract  = {The synthesis of galactose clusters that are linked to a steroid moiety by a peptide-like spacer unit is described. The galactose cluster is obtained by Koenigs-Knorr glycosylation of TRIS-Gly-Fmoc (2b) under Helferich conditions. Peptide and ester bonds are formed after activation of carboxylic acids as diphenylthiophene dioxide (TDO) esters. 6a is synthesized in a convergent way by coupling of (Ac4Gal)3-TRIS-Gly (3e) with cholesteryl TDO succinate (5b). Coupling of (Ac4Gal)3-TRIS-Gly hydrogen succinate (3f) with Gly-O-Chol (5d) by means of EEDQ yields 6d. Reaction of (Ac4Gal)3-TRIS-Gly-SUCC-O-TDO (3g) with 25-hydroxycholesterol leads in a linear sequence to the oxysterol derivative 6f. Selective cleavage of the acetyl groups from galactose units yields the known compound 6b and the new derivatives 6e and 6g.},
  language  = {de}
}
@article{VaajeKolstadVasellaPeteretal.2004,
  author    = {Vaaje-Kolstad, G. and Vasella, A. and Peter, Martin G. and Netter, C. and Houston, Douglas R. and Westereng, B. and Synstad, Bjoenar and Eijsink, Vincent G. H. and van Aalten, Daan M. F.},
  title     = {Interactions of a family 18 chitinase with the designed inhibitor HM508 and its degradation product, chitobiono- delta-lactone},
  issn      = {0021-9258},
  year      = {2004},
  abstract  = {We describe enzymological and structural analyses of the interaction between the family 18 chitinase ChiB from Serratia marcescens and the designed inhibitor N,N'-diacetylchitobionoxime-N-phenylcarbamate (HM508). HM508 acts as a competitive inhibitor of this enzyme with a K-i in the 50 muM range. Active site mutants of ChiB show K-i values ranging from 1 to 200 muM, providing insight into some of the interactions that determine inhibitor affinity. Interestingly, the wild type enzyme slowly degrades HM508, but the inhibitor is essentially stable in the presence of the moderately active D142N mutant of ChiB. The crystal structure of the D142N-HM508 complex revealed that the two sugar moieties bind to the -2 and -1 subsites, whereas the phenyl group interacts with aromatic side chains that line the +1 and +2 subsites. Enzymatic degradation of HM508, as well as a Trp-->Ala mutation in the +2 subsite of ChiB, led to reduced affinity for the inhibitor, showing that interactions between the phenyl group and the enzyme contribute to binding. Interestingly, a complex of enzymatically degraded HM508 with the wild type enzyme showed a chitobiono-delta- lactone bound in the -2 and -1 subsites, despite the fact that the equilibrium between the lactone and the hydroxy acid forms in solution lies far toward the latter. This shows that the active site preferentially binds the E-4 conformation of the -1 sugar, which resembles the proposed transition state of the reaction},
  language  = {en}
}
@article{RottmannSynstadThieleetal.1999,
  author    = {Rottmann, Antje and Synstad, Bjoenar and Thiele, G. and Schanzenbach, Dirk and Eijsink, Vincent G. H. and Peter, Martin G.},
  title     = {Approaches towards the design of new chitinase inhibitors},
  isbn      = {3-9806494-5-8},
  year      = {1999},
  language  = {en}
}
@phdthesis{BahrkeEinarssonGislasonetal.2003,
  author    = {Bahrke, Sven and Einarsson, Jon M. and Gislason, Johannes and Haebel, Sophie and Peter-Katalinic, Jasna and Peter, Martin G.},
  title     = {Characterization of chitooligosaccharides by mass spectrometry},
  isbn      = {82-47-15901-5},
  year      = {2003},
  language  = {en}
}
@article{RusuNgWilkeetal.2005,
  author    = {Rusu, Viorel Marin and Ng, C. H. and Wilke, Max and Tiersch, Brigitte and Fratzl, Peter and Peter, Martin G.},
  title     = {Size-controlled hydroxyapatite nanoparticles as self-organized organic-in organic composite materials},
  issn      = {0142-9612},
  year      = {2005},
  abstract  = {This paper presents some results concerning the size-controlled hydroxyapatite nanoparticles obtained in aqueous media in a biopolymer matrix from soluble precursors salts. Taking the inspiration from nature, where composite materials made of a polymer matrix and inorganic fillers are often found, e.g. bone, shell of crustaceans, shell of eggs, etc., the feasibility on making composite materials containing chitosan and nanosized hydroxyapatite was investigated. A stepwise co-precipitation approach was used to obtain different types of composites by means of different ratio between components. The synthesis of hydroxyapatite was carried out in the chitosan matrix from calcium chloride and sodium dihydrogenphosphate in alkaline solutions at moderate pH of 10-11 for 24 h. Our research is focused on studying and understanding the structure of this class of composites, aiming at the development of novel materials, controlled at the nanolevel scale. The X-ray diffraction technique was employed in order to study the kinetic of hydroxyapatite formation in the chitosan matrix as well as to determine the HAp crystallite sizes in the composite samples. The hydroxyapatite synthesized using this route was found to be nano-sized (15-50nm). Moreover, applying an original approach to analyze the (002) XRD diffraction peak profile of hydroxyapatite by using a sum of two Gauss functions, the bimodal distribution of nanosized hydroxyapatite within the chitosan matrix was revealed. Two types of size distribution domains such as cluster-like (between 200 and 400 nm), which are the habitat of "small" hydroxyapatite nanocrystallites and scattered-like, which are the habitat of "large" hydroxyapatite nanocrystallites was probed by TEM and CSLM. The structural features of composites suggest that self-assembly processes might be involved. The composites contain nanosized hydroxyapatite with structural features close to those of biological apatites that make them attractive for bone tissue engineering applications. (c) 2005 Elsevier Ltd. All rights reserved},
  language  = {en}
}
@misc{PeterAndersenHartmannetal.1992,
  author    = {Peter, Martin G. and Andersen, Svend Olav and Hartmann, Rudolf and Miessner, Merle and Roepstorff, Peter},
  title     = {Catecholamine-protein conjugates : isolation of 4-phenylphenoxazin-2-ones from oxidative coupling of N-acetyldopamine with alipathic amino acids},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-17571},
  year      = {1992},
  abstract  = {4-Phenylphenoxazinones were isolated after biomimetic oxidation, using diphenoloxidases of insect cuticle, mushroom tyrosinase, or after autoxidation of N-acetyldopamine (Image ) in the presence of β-alanine, β-alanine methyl ester or N-acetyl-L-lysine. They are formed presumably by addition of 2-aminoalkyl-5-alkylphenols to the o-quinone of biphenyltetrol which, in turn, arises from oxidative coupling of. The structures of present the first examples for the assembly of reasonably stable intermediates in the rather complex process of chemical modifications of aliphatic amino acid residues by o-quinones.},
  language  = {en}
}
@misc{PeterStuppLentes1983,
  author    = {Peter, Martin G. and Stupp, Hans-Peter and Lentes, Klaus-Ulrich},
  title     = {Umkehr der Enantioselektivit{\"a}t bei der enzymatischen Hydrolyse von Juvenilhormon als Ergebnis einer Proteinfraktionierung},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-17001},
  year      = {1983},
  abstract  = {Aus dem Inhalt: Die Juvenilhormone 1a-c werden im Blut von Insekten enzymatisch zu den biologisch inaktiven Sluren hydrolysiert. Bei der Hydrolyse von racemischem 1c im Blut der Wanderheuschrecke Locusta migratoria wird ein Umsatz von 40-60\% erreicht. Das unumgesetzte Edukt enth{\"a}llt einen {\"U}berschuß an nat{\"u}rlich konfiguriertem (10R)-1c (e.e. 47.2\%). Wir konnten zeigen, daß das in der H{\"a}molymphe vorhandene Hormon-Bindungsprotein bevorzugt mit (10R)- 1c assoziiert.},
  language  = {de}
}
@article{AndersenPeterRoepstorff1996,
  author    = {Andersen, S. O. and Peter, Martin G. and Roepstorff, Peter},
  title     = {Cuticular sclerotization in insects},
  year      = {1996},
  language  = {en}
}
@article{HaebelPeterKatalinicPeter1997,
  author    = {Haebel, Sophie and Peter-Katalinic, Jasna and Peter, Martin G.},
  title     = {Mass spectrometry of chitooligosaccharides},
  isbn      = {88-86889- 01-1},
  year      = {1997},
  language  = {en}
}
@article{BahrkeEinarssonGislasonetal.2002,
  author    = {Bahrke, Sven and Einarsson, Jon M. and Gislason, Johannes and Haebel, Sophie and Letzel, Matthias C. and Peter-Katalinic, Jasna and Peter, Martin G.},
  title     = {Sequence analysis of chitooligosaccharides by matrix-assisted laser desorption ionization postsource decay mass spectrometry},
  year      = {2002},
  abstract  = {Oligosaccharides composed of 2-acetamido-2-deoxy-D-glucopyranose (GlcNAc) and/or 2-amino-2-deoxy-D- glucopyranose (GlcN) were prepd. by chem. degrdn. of chitin or chitosan and sepd. by gel permeation chromatog. Oligosaccharides obtained after enzymic hydrolysis of chitosan [FA 0.19] with a fungal chitinase were derivatized by reductive amination with 2-aminoacridone and sequenced by matrix-assisted laser desorption ionization time-of-flight postsource decay (PSD) mass spectrometry (MS). The sequence of a trimer, D1A2, was established as D-A-A. The compn. of a hexamer D3A3 was .apprx.65\% D-A-D-D-A-A and 35\% D-D-A-D-A-A. The PSD MS of a nonamer D5A4-amac revealed four isobaric species D-X-Y-D-X-Y-D-A-A, where A is GlcNAc, D is GlcN, and X and Y (X ¹ Y) are mutually either D or A. This structure motif was also obsd. in a dodecamer D7A5 which was composed of eight isobaric sequences of the general formula (D-X-Y)3- D-A-A.},
  language  = {en}
}
@article{LetzelPeterKatalinicPeter2001,
  author    = {Letzel, Matthias C. and Peter-Katalinic, Jasna and Peter, Martin G.},
  title     = {Mass spectrometry of chitin and chitosan oligosaccharides},
  year      = {2001},
  language  = {en}
}
@article{JumaAkalaEyaseetal.2011,
  author    = {Juma, Wanyama P. and Akala, Hoseah M. and Eyase, Fredrick L. and Muiva, Lois M. and Heydenreich, Matthias and Okalebo, Faith A. and Gitu, Peter M. and Peter, Martin G. and Walsh, Douglas S. and Imbuga, Mabel and Yenesew, Abiy},
  title     = {Terpurinflavone an antiplasmodial flavone from the stem of Tephrosia Purpurea},
  series = {Phytochemistry letters},
  volume    = {4},
  journal   = {Phytochemistry letters},
  number    = {2},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1874-3900},
  doi       = {10.1016/j.phytol.2011.02.010},
  pages     = {176 -- 178},
  year      = {2011},
  abstract  = {The stem extract of Tephrosia purpurea showed antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum with IC(50) values of 10.47 +/- 2.22 mu g/ml and 12.06 +/- 2.54 mu g/ml, respectively. A new prenylated flavone, named terpurinflavone, along with the known compounds lanceolatin A, (-)-semiglabrin and lanceolatin B have been isolated from this extract. The new compound, terpurinflavone, showed the highest antiplasmodial activity with IC(50) values of 3.12 +/- 0.28 mu M (D6) and 6.26 +/- 2.66 mu M (W2). The structures were determined on the basis of spectroscopic evidence.},
  language  = {en}
}
@article{AndayiYenesewDereseetal.2006,
  author    = {Andayi, Andrew W. and Yenesew, Abiy and Derese, Solomon and Midiwo, Jacob O. and Gitu, Peter M. and Jondiko, Ogoche J. I. and Akala, Hoseah M. and Liyala, Pamela and Wangui, Julia and Waters, Norman C. and Heydenreich, Matthias and Peter, Martin G.},
  title     = {Antiplasmodial flavonoids from Erythrina sacleuxii},
  issn      = {0032-0943},
  doi       = {10.1055/s-2005-873200},
  year      = {2006},
  abstract  = {The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4 -methoxy-3'- prenylisoflavone (trivial name 5-deoxy-3' - prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from the stem bark of E. sucleuxii were also tested and showed antiplasmodial activities. The structures were determined on the basis of spectroscopic evidence},
  language  = {en}
}
@article{SchulzeMakuchWagnerKounavesetal.2018,
  author    = {Schulze-Makuch, Dirk and Wagner, Dirk and Kounaves, Samuel P. and Mangelsdorf, Kai and Devine, Kevin G. and de Vera, Jean-Pierre and Schmitt-Kopplin, Philippe and Grossart, Hans-Peter and Parro, Victor and Kaupenjohann, Martin and Galy, Albert and Schneider, Beate and Airo, Alessandro and Froesler, Jan and Davila, Alfonso F. and Arens, Felix L. and Caceres, Luis and Cornejo, Francisco Solis and Carrizo, Daniel and Dartnell, Lewis and DiRuggiero, Jocelyne and Flury, Markus and Ganzert, Lars and Gessner, Mark O. and Grathwohl, Peter and Guan, Lisa and Heinz, Jacob and Hess, Matthias and Keppler, Frank and Maus, Deborah and McKay, Christopher P. and Meckenstock, Rainer U. and Montgomery, Wren and Oberlin, Elizabeth A. and Probst, Alexander J. and Saenz, Johan S. and Sattler, Tobias and Schirmack, Janosch and Sephton, Mark A. and Schloter, Michael and Uhl, Jenny and Valenzuela, Bernardita and Vestergaard, Gisle and Woermer, Lars and Zamorano, Pedro},
  title     = {Transitory microbial habitat in the hyperarid Atacama Desert},
  series = {Proceedings of the National Academy of Sciences of the United States of America},
  volume    = {115},
  journal   = {Proceedings of the National Academy of Sciences of the United States of America},
  number    = {11},
  publisher = {National Acad. of Sciences},
  address   = {Washington},
  issn      = {0027-8424},
  doi       = {10.1073/pnas.1714341115},
  pages     = {2670 -- 2675},
  year      = {2018},
  language  = {en}
}
@article{EijsinkSynstadGaseidnesetal.2003,
  author    = {Eijsink, Vincent G. H. and Synstad, Bjoenar and Gaseidnes, Sigrid and Komander, David and Houston, Douglas R. and Peter, Martin G. and van Aalten, Daan M. F.},
  title     = {Structure and function of chitinolytic enzymes},
  isbn      = {82-471-5901-5},
  year      = {2003},
  abstract  = {The recent work on a variety of family 18 chitonolytic enzymes has yielded important data concerning the structure, substrate-binding, catalysis, inhibitor-binding and even dynamics. These data have been useful in helping to better understand the roles of various types of chitinases in chitin hydrolysis, to rationally engineer the properties of these enzymes, thus making them more suitable as biocatalysts, and to study and understand the effectiveness of natural and designed chitinase inhibitors, which may be of medical interest. On the other hand, the recent work on ChiB shows that catalysis in family 18 chitinases is a highly complicated process, involving larger parts of the enzyme and dynamics. Thus, despite recent discoveries, there is still a lot more to discover about how these enzyme work.},
  language  = {en}
}
@article{BringmannMutanyattaComarMaksimenkaetal.2008,
  author    = {Bringmann, Gerhard and Mutanyatta-Comar, Joan and Maksimenka, Katja and Wanjohi, John M. and Heydenreich, Matthias and Brun, Reto and M{\"u}ller, Werner E. G. and Peter, Martin G. and Midiwo, Jacob O. and Yenesew, Abiy},
  title     = {Joziknipholones A and B : the first dimeric phenylanthraquinones, from the roots of Bulbine frutescens},
  issn      = {0947-6539},
  year      = {2008},
  abstract  = {From the roots of the African plant Bulbine frutescens (Asphodelaceae), two unprecedented novel dimeric phenylanthraquinones, named joziknipholones A and B, possessing axial and centrochirality, were isolated, together with six known compounds. Structural elucidation of the new metabolites was achieved by spectroscopic and chiroptical methods, by reductive cleavage of the central bond between the monomeric phenylanthraquinone and -anthrone portions with sodium dithionite, and by quantum chemical CD calculations. Based on the recently revised absolute axial configuration of the parent phenylanthraquinones, knipholone and knipholone anthrone, the new dimers were attributed to possess the P- configuration (i.e., with the acetyl portions below the anthraquinone plane) at both axes in the case of joziknipholone A, whereas in joziknipholone B, the knipholone part was found to be M-configured. Joziknipholones A and B are active against the chloroquine resistant strain K1 of the malaria pathogen, Plasmodium falciparum, and show moderate activity against murine leukemic lymphoma L5178y cells.},
  language  = {en}
}
@article{SchumacherWanderslebPetersenPeter1994,
  author    = {Schumacher-Wandersleb, Michael H. M. G. and Petersen, Stefan and Peter, Martin G.},
  title     = {Preparation of the N-Acetylglucosaminidase inhibitor 1-Acetamido-1,2,5-tride oxy-2,5-imino-D-glucitol from methyl a-D-Mannopyranoside},
  year      = {1994},
  language  = {en}
}
@article{PeterLeyPetersenetal.1994,
  author    = {Peter, Martin G. and Ley, J. P. and Petersen, Stefan and Londershausen, M. and Schumacher-Wandersleb, Michael H. M. G. and Spindler, Klaus-Dieter and Spindler-Barth, Margarethe and Turberg, Andreas},
  title     = {Synthesis of chitinase inhibitors},
  year      = {1994},
  language  = {en}
}
@article{RukungaMuregiOmaretal.2008,
  author    = {Rukunga, G. M. and Muregi, F. W. and Omar, S. A. and Gathirwa, J. W. and Muthaura, C. N. and Peter, Martin G.},
  title     = {Anti-plasmodial activity of the extracts and two sesquiterpenes from Cyperus articulatus},
  issn      = {0367-326X},
  year      = {2008},
  abstract  = {Two sesquiterpenes, corymbolone and mustakone, isolated from the chloroform extract of the rhizomes of Cyperus articulatus, exhibited significant anti-plasmodial properties. Mustakone was approximately ten times more active than corymbolone against the sensitive strains of the Plasmodium falciparum.},
  language  = {en}
}
@article{StrefferKaatzBaueretal.1998,
  author    = {Streffer, Katrin and Kaatz, Helvi and Bauer, Christian G. and Makower, Alexander and Schulmeister, Thomas and Scheller, Frieder W. and Peter, Martin G. and Wollenberger, Ursula},
  title     = {Application of a sensitive catechol detector for determination of tyrosinase inhibitors},
  year      = {1998},
  language  = {en}
}
@article{SchumacherWanderslebPeter1995,
  author    = {Schumacher-Wandersleb, Michael H. M. G. and Peter, Martin G.},
  title     = {Synthesis of chitobiosyl pyrrolidines},
  year      = {1995},
  language  = {en}
}
@article{FasciottiSanvidoSantosetal.2012,
  author    = {Fasciotti, Maira and Sanvido, Gustavo B. and Santos, Vanessa G. and Lalli, Priscila M. and McCullagh, Michael and de Sa, Gilberto F. and Daroda, Romeu J. and Peter, Martin G. and Eberlin, Marcos N.},
  title     = {Separation of isomeric disaccharides by traveling wave ion mobility mass spectrometry using CO2 as drift gas},
  series = {Journal of mass spectrometr},
  volume    = {47},
  journal   = {Journal of mass spectrometr},
  number    = {12},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {1076-5174},
  doi       = {10.1002/jms.3089},
  pages     = {1643 -- 1647},
  year      = {2012},
  abstract  = {The use of CO2 as a massive and polarizable drift gas is shown to greatly improve peak-to-peak resolution (Rp-p), as compared with N2, for the separation of disaccharides in a Synapt G2 traveling wave ion mobility cell. Near or baseline Rp-p was achieved for three pairs of sodiated molecules of disaccharide isomers, that is, cellobiose and sucrose (Rp-p?=?0.76), maltose and sucrose (Rp-p?=?1.04), and maltose and lactose (Rp-p?=?0.74). Ion mobility mass spectrometry using CO2 as the drift gas offers therefore an attractive alternative for fast and efficient separation of isomeric disaccharides.},
  language  = {en}
}
@article{HoustonShiomiAraietal.2002,
  author    = {Houston, Douglas R. and Shiomi, Kazuro and Arai, Noriko and Omura, Satoshi and Peter, Martin G. and Turberg, Andreas and Synstad, Bjoenar and Eijsink, Vincent G. H. and Van Aalten, Daan M. F.},
  title     = {High-resolution structures of a chitinase complexed with natural product cyclopentapeptide inhibitors : mimicry of carbohydrate substrate},
  year      = {2002},
  abstract  = {Over the past years, family 18 chitinases have been validated as potential targets for the design of drugs against human pathogens that contain or interact with chitin during their normal life cycles. Thus far, only one potent chitinase inhibitor has been described in detail, the pseudotrisaccharide allosamidin. Recently, however, two potent natural-product cyclopentapeptide chitinase inhibitors, argifin and argadin, were reported. Here, we describe high- resoln. crystal structures that reveal the details of the interactions of these cyclopeptides with a family 18 chitinase. The structures are examples of complexes of a carbohydrate-processing enzyme with high-affinity peptide-based inhibitors and show in detail how the peptide backbone and side chains mimic the interactions of the enzyme with chitooligosaccharides. Together with enzymol. characterization, the structures explain why argadin shows an order of magnitude stronger inhibition than allosamidin, whereas argifin shows weaker inhibition. The peptides bind to the chitinase in remarkably different ways, which may explain the differences in inhibition consts. The two complexes provide a basis for structure-based design of potent chitinase inhibitors, accessible by std. peptide chem.},
  language  = {en}
}
@article{vanAaltenKomanderSynstadetal.2002,
  author    = {van Aalten, Daan M. F. and Komander, David and Synstad, Bjoenar and Gaseidnes, Sigrid and Peter, Martin G. and Eijsink, Vincent G. H.},
  title     = {Structural Insights into the catalytic mechanism of a family 18 exochitinase},
  year      = {2002},
  abstract  = {Chitinase B (ChiB) from Serratia marcescens is a family 18 exochitinase whose catalytic domain has a TIM-barrel fold with a tunnel-shaped active site. We have solved structures of three ChiB complexes that reveal details of substrate binding, substrateassisted catalysis, and product displacement. The structure of an inactive ChiB mutant (E144Q) complexed with a pentameric substrate (binding in subsites 22 to 13) shows closure of the ''roof'' of the active site tunnel. It also shows that the sugar in the 21 position is distorted to a boat conformation, thus providing structural evidence in support of a previously proposed catalytic mechanism. The structures of the active enzyme complexed to Allosamidin (an analogue of a proposed reaction intermediate) and of the active enzyme soaked with pentameric substrate show events after cleavage of the glycosidic bond. The latter structure shows reopening of the roof of the active site tunnel and enzyme-assisted product displacement in the 11 and 12 sites, allowing a water molecule to approach the reaction center. Catalysis is accompanied by correlated structural changes in the core of the TIM barrel that involve conserved polar residues whose functions were hitherto unknown. These changes simultaneously contribute to stabilization of the reaction intermediate and alternation of the pKa of the catalytic acid during the catalytic cycle.},
  language  = {en}
}
@article{RottmannSynstadEijsinketal.1999,
  author    = {Rottmann, Antje and Synstad, Bjoenar and Eijsink, Vincent G. H. and Peter, Martin G.},
  title     = {Synthesis of N-acetylglucosaminyl and diacetylchitobiosyl amides of heterocyclic carboxylic acids as potential chitinase inhibitors},
  year      = {1999},
  language  = {en}
}
@article{ThieleRottmannGermeretal.2002,
  author    = {Thiele, Gabriela and Rottmann, Antje and Germer, Antje and Kleinpeter, Erich and Spindler, Klaus-Dieter and Synstad, Bjoenar and Eijsink, Vincent G. H. and Peter, Martin G.},
  title     = {Synthesis and conformational analysis of pseudosugar analogues of chitotriose},
  year      = {2002},
  abstract  = {In this article, the synthesis of analogs of N,N',N''-triacetylchitotriose in which the central sugar residue was replaced by a succinic acid is presented. Mol. modeling calcns. revealed that the pseudotrisaccharides exist in low energy extended conformations which show similar space filling as N,N',N''-triacetylchitotriose. Of the N,N',N''-triacetylchitotriose pseudosugar analogs tested as chitinase inhibitors, none showed any appreciable competition (numerical data not presented). The conformational anal. along with further synthetic efforts will hopefully lead to more efficient pseudosaccharides as chitinase inhibitors.},
  language  = {en}
}
@article{KroescheCrescenziHoffbaueretal.1994,
  author    = {Kr{\"o}sche, Christian and Crescenzi, Orlando and Hoffbauer, Wilfried and Jansen, Martin and Napolitano, Alessandra and Prota, Guiseppe and Peter, Martin G.},
  title     = {Synthesis of dopamines labelled with 13C in the alpha- or beta-side chain positions, and their application for structure studies on melanins by solid state NMR spectroscopy},
  year      = {1994},
  language  = {en}
}
@article{PeikowMaternPeteretal.2005,
  author    = {Peikow, Dirk and Matern, Christa-Maria and Peter, Martin G. and Schilde, Uwe},
  title     = {Crystal structure of (1,4,7,10,13-pentaoxacyclopentadecane-O,O ',O '',O ''')(trifluoromethanesulfonato-O,O ')sodium, Na(C10H20O5)(CF3SO3)},
  year      = {2005},
  abstract  = {C11H20F3NaO8S, monoclinic, P121/nil (no. 11), a = 7.947(1) angstrom, b = 12.056(1) angstrom, c = 9.083(1) angstrom, P = 106.01 (1)degrees, V = 836.4 angstrom(3), Z = 2, R-gt(F) = 0.043, wR(ref)(F-2) = 0.120, T = 210 K.},
  language  = {en}
}
@article{AlarconAldereteAguilaetal.2005,
  author    = {Alarcon, Julio and Alderete, Joel B. and Aguila, Sergio and Peter, Martin G.},
  title     = {Regio and stereoselective hydroxylation of alpha-agarofuran by biotransformation of rhizopus nigricans},
  year      = {2005},
  abstract  = {A new synthesis of 9 alpha-hydroxy-alpha-agarofuran (6 alpha) is described, using a microbiological hydroxylation alpha-agarofuran (5) as the key reaction. The stereochemistry of the biohydroxylation was determined on the basis of a NOESY-experiment and GIAO calculations at the B3LYP/cc-pVDZ level. A strong gamma-effect was observed at C15 of the agarofuran ring which was correctly predicted by the GIAO-B3LYP calculations},
  language  = {en}
}
@article{FotieNkengfackPeteretal.2004,
  author    = {Fotie, J. and Nkengfack, A. E. and Peter, Martin G. and Heydenreich, Matthias and Fomum, Z. T.},
  title     = {Chemical constituents of the ethyl acetate extracts of the stem bark and fruits of Dichrostachys cinerea and the roots of Parkia bicolor},
  issn      = {1011-3924},
  year      = {2004},
  abstract  = {The antibacterial activities of ethyl acetate, methanol and aqueous extracts of the stem bark of Dichrostachys cinerea and the roots of Parkia bicolor have been evaluated. Ethyl acetate extracts have been investigated, studies that led to a series of known compounds, amongst which many are reported here for the very first time from both the species},
  language  = {en}
}
@article{BerthDautzenbergPeter1998,
  author    = {Berth, Gisela and Dautzenberg, Herbert and Peter, Martin G.},
  title     = {Physica-chemical characterization of chitosans in dilute solution},
  isbn      = {2-907922-57-2},
  year      = {1998},
  language  = {en}
}
@article{KamlageSefkowZimmermannetal.2002,
  author    = {Kamlage, Stefan and Sefkow, Michael and Zimmermann, Nicole and Peter, Martin G.},
  title     = {Concise synthesis of (+)-beta-benzyl gamma-butyrolactones from butynediol},
  year      = {2002},
  language  = {en}
}
@article{Peter2002,
  author    = {Peter, Martin G.},
  title     = {Chitin and Chitosan from Animal Sources},
  isbn      = {3-527-30227-1},
  year      = {2002},
  abstract  = {A review on the chem. and biochem. of chitin and the chem. and application of chitosan. The following topics were discussed: structure of chitin and chitosan; occurrence and physiol. functions of chitin; detection of chitin in animals and anal. of chitin and chitosan; biosynthesis and biodegrdn. of chitin in animals; prodn. of chitin and chitosan; properties of chitin and chitosan; and applications of chitin and chitosan.},
  language  = {en}
}
@article{Peter2002,
  author    = {Peter, Martin G.},
  title     = {Chitin and Chitosan from Fungi},
  isbn      = {3-527-30227-1},
  year      = {2002},
  language  = {en}
}
@misc{FerenzPeterBerg1983,
  author    = {Ferenz, Hans-J{\"u}rgen and Peter, Martin G. and Berg, Dieter},
  title     = {Inhibition of farnesoic acid methyltransferase by sinefungin},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-17016},
  year      = {1983},
  abstract  = {Sinefungin inhibited the S-adenosylmethionine-dependent farnesoic acid methyltransferase in a cell-free system containing a homogenate of corpora allata from female locusts, Locusta migratoria. The enzyme catalyzed the penultimate step of juvenile hormone biosynthesis in the insects. Culturing corpora allata in the presence of sinefungin greatly suppressed juvenile hormone production. The following in vivo effects were visible after injection of the inhibitor: increase in mortality and reduction of total haemolymph protein liter and ovary fresh weight, as well as length of terminal oocytes. Attempts to reverse these effects by topical application of the juvenile hormone analog ZR-515 (methoprene) were only partly successful. Therefore, the in vivo effects may be due to a general inhibition of methyltransferase enzymes in the insect. Sinefungin appeared to be of potential interest as the first representative of a new class of insect growth regulators.},
  language  = {en}
}
@misc{KortPeterKoopmanschap1983,
  author    = {Kort, C. A. D. de and Peter, Martin G. and Koopmanschap, A. B.},
  title     = {Binding and degradation of juvenile hormone III by haemolymph proteins of the Colorado potato beetle: a re-examination},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-16777},
  year      = {1983},
  abstract  = {The haemolymph of the adult Colorado potato beetle, Lepinotarsa decemlineata Say, contains a high molecular weight (MW > 200,000) JH-III specific binding protein. The Kd value of the protein for racemic JH-III is 1.3 ± 0.2 × 10-7 M. It has a lower affinity for racemic JH-I and it does not bind JH-III-diol or JH-III-acid. The binding protein does discriminate between the enantiomers of synthetic, racemic JH-III as was determined by stereochemical anaysis of the bound and the free JH-III. Incubation of racemic JH-III with crude haemolymph results in preferential formation of (10S)-JH-III-acid, the unnatural configuration. The JH-esterase present in L. decemlineata haemolymph is not enantioselective. It is concluded that the most important function of the binding protein is that of a specific carrier, protecting the natural hormone against degradation by esterases. The carrier does not protect JH-I as efficiently as the lower homologue.},
  language  = {en}
}
@misc{PeterFoerster1989,
  author    = {Peter, Martin G. and F{\"o}rster, Hans},
  title     = {On the structure of Eumelanins : identification of constitutional patterns by solid-state NMR spectroscopy},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-17027},
  year      = {1989},
  abstract  = {Aus dem Inhalt: Melanins are complex polyphenolic polymers. They are usually formed in nature by enzyme-catalyzed oxidative polymerization of o-diphenols. The deep black eumelanins, derived from Dopa 1 or dopamine 3, are distinguished from the yellow to brown phaeomelanins obtained from Dopa in the presence of cysteine. Characteristic of eumelanins are the indole units, which are formed from catecholamines by intramolecular addition of the amino groups to the oxidatively generated o-quinones. [...]},
  language  = {en}
}
@article{WanjohiYenesewMidiwoetal.2005,
  author    = {Wanjohi, John M. and Yenesew, Abiy and Midiwo, Jacob O. and Heydenreich, Matthias and Peter, Martin G. and Dreyer, M. and Reichert, M. and Bringmann, Gerhard},
  title     = {Three dimeric anthracene derivatives from the fruits of Bulbine abyssinica},
  issn      = {0040-4020},
  year      = {2005},
  abstract  = {From the fruits of Bulbine abyssinica three new dimeric anthracene derivatives, (P)-8,9,1',8'- tetrahydroxy-3,3'-dimethyl[10,7'-bianthracene]-1,4,9',10'- tetraone (trivial name abyquinone A), (10R)-1,4,8,1',8-pentahydroxy-3,3'-dimethyl-[10,7'-bianthracene]9,9',10' (10H)-trione (trivial name abyquinone B), and (10R)-3,4'-dihydro-1,4,8,3',8',9'-hexahydroxy-3,3'- dimethyl-[10,7'-biant hracene]9,1'(10H,2'H)-dione (trivial name abyquinone Q were isolated. Despite their structural differences, these three compounds are connected to each other by the apparently biomimetic conversion of abyquinone C (a preanthraquinonylanthrone with two stereogenic centers) into B (an anthraquinonylanthrone with one stereogenic center) and finally into A (an axially chiral bianthraquinone) under mild conditions, involving a highly efficient center-to-axis chirality transfer. In addition, the known anthraquinones islandicin and chrysophanol were identified. The structures were determined on the basis of spectroscopical evidences, chemical transformations, and quantum chemical CD calculations. (C) 2005 Elsevier Ltd. All rights reserved},
  language  = {en}
}
@article{YenesewKiplagatDereseetal.2006,
  author    = {Yenesew, Abiy and Kiplagat, John T. and Derese, Solomon and Midiwo, Jacob O. and Kabaru, Jacques M. and Heydenreich, Matthias and Peter, Martin G.},
  title     = {Two unusual rotenoid derivatives, 7a-O-methyl-12a-hydroxydeguelol and spiro-13-homo-13-oxaelliptone, from the seeds of Derris trifoliata},
  doi       = {10.1016/j.phytochem.2006.01.002},
  year      = {2006},
  abstract  = {The crude methanol extract of the seeds of Derris trifoliata showed potent and dose dependent larvicidal activity against the 2nd instar larvae of Aedes aegypti. From this extract two unusual rotenoid derivatives, a rotenoloid (named 7a-O-methyl-12a-hydroxydeguelol) and a spirohomooxarotenoid (named spiro-13-homo-13-oxaelliptone), were isolated and characterised. In addition a rare natural chromanone (6,7-dimethoxy-4-chromanone) and the known rotenoids rotenone, tephrosin and dehydrodeguelin were identified. The structures were assigned on the basis of spectroscopic evidence. The larvicidal activity of the crude extract is mainly due to rotenone. (c) 2006 Elsevier Ltd. All rights reserved},
  language  = {en}
}
@article{YenesewMidiwoGuchuetal.2002,
  author    = {Yenesew, Abiy and Midiwo, Jacob O. and Guchu, S. M. and Heydenreich, Matthias and Peter, Martin G.},
  title     = {Three iosoflav-3-enes and a 2-arylbenzofuran from the root bark of Erythrina burttii},
  year      = {2002},
  abstract  = {From the root bark of Erythrina burttii three new isoflav-3-enes, 7,4'-dihydroxy-2'-methoxy-6- (1'',1''-dimethylallyl)isoflav-3-ene (trivial name, burttinol-A), 4'-hydroxy-2'- methoxy-(2'',2''-dimethylpyrano[5'',6'':8,7]isoflav-3-ene (trivial name, burttinol-B), 7,4'-dihydroxy-2'-methoxy-8-(3'',3''-dimethylallyl)isoflav-3-ene (trivial name, burttinol-C), and a new 2-arylbenzofuran, 6,4'-dihydroxy-2'-methoxy-5- (1'',1''-dimethylallyl)-2-arylbenzofuran (trivial name, burttinol-D) were isolated. In addition, the known compounds, abyssinone V-4'-methyl ether, bidwillol A, calopocarpin, erybraedin A, erythrabyssin II, isobavachalcone, phaseollidin and phaseollin were identified. The structures were determined on the basis of spectroscopic evidence.},
  language  = {en}
}
@article{YenesewMushibeIndulietal.2005,
  author    = {Yenesew, Abiy and Mushibe, E. K. and Induli, M. and Derese, Solomon and Midiwo, Jacob O. and Kabaru, Jacques M. and Heydenreich, Matthias and Koch, Andreas and Peter, Martin G.},
  title     = {7a-O-methyldeguelol, a modified rotenoid with an open ring-C, from the roots of Derris trifoloata},
  issn      = {0031-9422},
  year      = {2005},
  abstract  = {From the acetone extract of the roots of Derris trifoliata an isollavonoid derivative, named 7a-O- methyldeguelol, a modified rotenoid with an open ring-C, representing a new sub-class of isollavonoids (the sub-class is here named as rotenoloid), was isolated and characterised. In addition, the known rotenoids, rotenone, deguelin and alpha-toxicarol, were identified. The structures were determined on the basis of spectroscopic evidence. Rotenone and deguelin were identified as the larvicidal principles of the acetone extract of the roots of Derris trifoliata. (c) 2005 Elsevier Ltd. All rights reserved},
  language  = {en}
}
@article{YenesewIrunguDereseetal.2003,
  author    = {Yenesew, Abiy and Irungu, Beatrice and Derese, Solomon and Midiwo, Jacob O. and Heydenreich, Matthias and Peter, Martin G.},
  title     = {Two prenylated flavonoids from the stem bark of Erythrina burttii},
  year      = {2003},
  abstract  = {From the stem bark of Erythrina burttii, a new isoflavone, 5,2',4'-trihydroxy-7-methoxy-6-(3- methylbut-2-enyl)isoflavone (trivial name, 7-O-methylluteone) and a new flavanone, 5,7-dihydroxy-4'-methoxy- 3'-(3-methylbutadienyl)-5'-(3-methylbut-2-enyl)flavanone (trivial name, burttinonedehydrate) along with three known isoflavonoids (8-prenylluteone, 3-O-methylcalopocarpin and genistein) were isolated. The structures were detd. on the basis of spectroscopic evidence.},
  language  = {en}
}
@article{YenesewDereseMidiwoetal.2005,
  author    = {Yenesew, Abiy and Derese, Solomon and Midiwo, Jacob O. and Bii, Christine C. and Heydenreich, Matthias and Peter, Martin G.},
  title     = {Antimicrobial flavonoids from the stem bark of Erythrina burttii},
  issn      = {0367-326X},
  year      = {2005},
  abstract  = {The chloroform extract of the stem bark of Erythrina burttii showed antifungal and antibacterial activities using the disk diffusion method. Flavonoids were identified as the active principles. Activities were observed against fungi and Gram(+) bacteria, but the Gram(-) bacteria Escherichia coli was resistant. (c) 2005 Elsevier B.V. All rights reserved},
  language  = {en}
}
@phdthesis{DereseYenesewMidiwoetal.2003,
  author    = {Derese, Solomon and Yenesew, Abiy and Midiwo, Jacob O. and Heydenreich, Matthias and Peter, Martin G.},
  title     = {A new isoflavone from stem bark of Millettia dura},
  issn      = {1011-3924},
  year      = {2003},
  language  = {en}
}
@article{YenesewMidiwoMeisneretal.1998,
  author    = {Yenesew, Abiy and Midiwo, Jacob O. and Meisner, M. and Heydenreich, Matthias and Peter, Martin G.},
  title     = {Two prenylated flavanones from stem bark of erythrina burttii},
  year      = {1998},
  language  = {en}
}
@article{YenesewMidiwoHeydenreichetal.1998,
  author    = {Yenesew, Abiy and Midiwo, Jacob O. and Heydenreich, Matthias and Peter, Martin G.},
  title     = {Four isoflavanones from stem bark of erythrina sacleuxii},
  year      = {1998},
  language  = {en}
}
@misc{BringmannMutanyattaComarMaksimenkaetal.2008,
  author    = {Bringmann, Gerhard and Mutanyatta-Comar, Joan and Maksimenka, Katja and Wanjohi, John M. and Heydenreich, Matthias and Brun, Reto and M{\"u}ller, Werner E. G. and Peter, Martin and Midiwo, Jacob O. and Yenesew, Abiy},
  title     = {Joziknipholones A and B : the First Dimeric Phenylanthraquinones, from the Roots of Bulbine frutescens},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-42638},
  year      = {2008},
  abstract  = {From the roots of the African plant Bulbine frutescens (Asphodelaceae), two unprecedented novel dimeric phenylanthraquinones, named joziknipholones A and B, possessing axial and centrochirality, were isolated, together with six known compounds. Structural elucidation of the new metabolites was achieved by spectroscopic and chiroptical methods, by reductive cleavage of the central bond between the monomeric phenylanthraquinone and -anthrone portions with sodium dithionite, and by quantum chemical CD calculations. Based on the recently revised absolute axial configuration of the parent phenylanthraquinones, knipholone and knipholone anthrone, the new dimers were attributed to possess the P-configuration (i.e., with the acetyl portions below the anthraquinone plane) at both axes in the case of joziknipholone A, whereas in joziknipholone B, the knipholone part was found to be M-configured. Joziknipholones A and B are active against the chloroquine resistant strain K1 of the malaria pathogen, Plasmodium falciparum, and show moderate activity against murine leukemic lymphoma L5178y cells.},
  language  = {en}
}
@misc{Peter1989,
  author    = {Peter, Martin G.},
  title     = {Chemische Modifikation von Biopolymeren durch Chinone und Chinonmethide},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-16802},
  year      = {1989},
  abstract  = {Chinone und Vorstufen, die oxidativ in Chinone und/oder Chinonmethide umgewandelt werden k{\"o}nnen, sind in der Natur weit verbreitet. Als sekund{\"a}re Naturstoffe wirken sie h{\"a}ufig antibiotisch, cytotoxisch, aber auch pathogen, und eine Reihe von Pflanzen und Tieren benutzt chinoide Substanzen als Abwehrstoffe, oft mit spektakul{\"a}rem Erfolg. Auf makromolekularer Ebene spielen Chinonmethide im Pflanzenreich eine Schl{\"u}sselrolle bei der Biosynthese von Lignin, w{\"a}hrend die Bildung von Melanoproteinen ein Beispiel f{\"u}r Reaktionen von o-Chinonen im Tierreich ist. Bei den Insekten dienen Chinone und Chinonmethide zur Bildung des lebensnotwendigen Exoskeletts. Die Reaktivit{\"a}t von Chinonen in biologischen Systemen hat auch f{\"u}r den Menschen unmittelbare Bedeutung in pharmazeutischer, toxikologischer und technologischer Hinsicht. Den Beispielen in diesem Aufsatz liegt ein gemeinsames Prinzip zugrunde, n{\"a}mlich die chemische Modifikation von Biopolymeren durch Chinone und Chinonmethide. Wie sich besonders bei einer detaillierteren Betrachtung der Reaktionen zeigt, die zur Sklerotisierung der Insektencuticula f{\"u}hren, sind in den letzten Jahren wichtige neue Erkenntnisse hinzugekommen, die vor allem durch die modernen Methoden der Stofftrennung und der Festk{\"o}rper-NMR-Spektroskopie erm{\"o}glicht worden sind.},
  language  = {de}
}