@article{WuttkeLiLietal.2019, author = {Wuttke, Matthias and Li, Yong and Li, Man and Sieber, Karsten B. and Feitosa, Mary F. and Gorski, Mathias and Tin, Adrienne and Wang, Lihua and Chu, Audrey Y. and Hoppmann, Anselm and Kirsten, Holger and Giri, Ayush and Chai, Jin-Fang and Sveinbjornsson, Gardar and Tayo, Bamidele O. and Nutile, Teresa and Fuchsberger, Christian and Marten, Jonathan and Cocca, Massimiliano and Ghasemi, Sahar and Xu, Yizhe and Horn, Katrin and Noce, Damia and Van der Most, Peter J. and Sedaghat, Sanaz and Yu, Zhi and Akiyama, Masato and Afaq, Saima and Ahluwalia, Tarunveer Singh and Almgren, Peter and Amin, Najaf and Arnlov, Johan and Bakker, Stephan J. L. and Bansal, Nisha and Baptista, Daniela and Bergmann, Sven and Biggs, Mary L. and Biino, Ginevra and Boehnke, Michael and Boerwinkle, Eric and Boissel, Mathilde and B{\"o}ttinger, Erwin and Boutin, Thibaud S. and Brenner, Hermann and Brumat, Marco and Burkhardt, Ralph and Butterworth, Adam S. and Campana, Eric and Campbell, Archie and Campbell, Harry and Canouil, Mickael and Carroll, Robert J. and Catamo, Eulalia and Chambers, John C. and Chee, Miao-Ling and Chee, Miao-Li and Chen, Xu and Cheng, Ching-Yu and Cheng, Yurong and Christensen, Kaare and Cifkova, Renata and Ciullo, Marina and Concas, Maria Pina and Cook, James P. and Coresh, Josef and Corre, Tanguy and Sala, Cinzia Felicita and Cusi, Daniele and Danesh, John and Daw, E. Warwick and De Borst, Martin H. and De Grandi, Alessandro and De Mutsert, Renee and De Vries, Aiko P. J. and Degenhardt, Frauke and Delgado, Graciela and Demirkan, Ayse and Di Angelantonio, Emanuele and Dittrich, Katalin and Divers, Jasmin and Dorajoo, Rajkumar and Eckardt, Kai-Uwe and Ehret, Georg and Elliott, Paul and Endlich, Karlhans and Evans, Michele K. and Felix, Janine F. and Foo, Valencia Hui Xian and Franco, Oscar H. and Franke, Andre and Freedman, Barry I. and Freitag-Wolf, Sandra and Friedlander, Yechiel and Froguel, Philippe and Gansevoort, Ron T. and Gao, He and Gasparini, Paolo and Gaziano, J. Michael and Giedraitis, Vilmantas and Gieger, Christian and Girotto, Giorgia and Giulianini, Franco and Gogele, Martin and Gordon, Scott D. and Gudbjartsson, Daniel F. and Gudnason, Vilmundur and Haller, Toomas and Hamet, Pavel and Harris, Tamara B. and Hartman, Catharina A. and Hayward, Caroline and Hellwege, Jacklyn N. and Heng, Chew-Kiat and Hicks, Andrew A. and Hofer, Edith and Huang, Wei and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Indridason, Olafur S. and Ingelsson, Erik and Ising, Marcus and Jaddoe, Vincent W. V. and Jakobsdottir, Johanna and Jonas, Jost B. and Joshi, Peter K. and Josyula, Navya Shilpa and Jung, Bettina and Kahonen, Mika and Kamatani, Yoichiro and Kammerer, Candace M. and Kanai, Masahiro and Kastarinen, Mika and Kerr, Shona M. and Khor, Chiea-Chuen and Kiess, Wieland and Kleber, Marcus E. and Koenig, Wolfgang and Kooner, Jaspal S. and Korner, Antje and Kovacs, Peter and Kraja, Aldi T. and Krajcoviechova, Alena and Kramer, Holly and Kramer, Bernhard K. and Kronenberg, Florian and Kubo, Michiaki and Kuhnel, Brigitte and Kuokkanen, Mikko and Kuusisto, Johanna and La Bianca, Martina and Laakso, Markku and Lange, Leslie A. and Langefeld, Carl D. and Lee, Jeannette Jen-Mai and Lehne, Benjamin and Lehtimaki, Terho and Lieb, Wolfgang and Lim, Su-Chi and Lind, Lars and Lindgren, Cecilia M. and Liu, Jun and Liu, Jianjun and Loeffler, Markus and Loos, Ruth J. F. and Lucae, Susanne and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Magi, Reedik and Magnusson, Patrik K. E. and Mahajan, Anubha and Martin, Nicholas G. and Martins, Jade and Marz, Winfried and Mascalzoni, Deborah and Matsuda, Koichi and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Metspalu, Andres and Mikaelsdottir, Evgenia K. and Milaneschi, Yuri and Miliku, Kozeta and Mishra, Pashupati P. and Program, V. A. Million Veteran and Mohlke, Karen L. and Mononen, Nina and Montgomery, Grant W. and Mook-Kanamori, Dennis O. and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nalls, Mike A. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and Noordam, Raymond and Olafsson, Isleifur and Oldehinkel, Albertine J. and Orho-Melander, Marju and Ouwehand, Willem H. and Padmanabhan, Sandosh and Palmer, Nicholette D. and Palsson, Runolfur and Penninx, Brenda W. J. H. and Perls, Thomas and Perola, Markus and Pirastu, Mario and Pirastu, Nicola and Pistis, Giorgio and Podgornaia, Anna I. and Polasek, Ozren and Ponte, Belen and Porteous, David J. and Poulain, Tanja and Pramstaller, Peter P. and Preuss, Michael H. and Prins, Bram P. and Province, Michael A. and Rabelink, Ton J. and Raffield, Laura M. and Raitakari, Olli T. and Reilly, Dermot F. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Ridker, Paul M. and Rivadeneira, Fernando and Rizzi, Federica and Roberts, David J. and Robino, Antonietta and Rossing, Peter and Rudan, Igor and Rueedi, Rico and Ruggiero, Daniela and Ryan, Kathleen A. and Saba, Yasaman and Sabanayagam, Charumathi and Salomaa, Veikko and Salvi, Erika and Saum, Kai-Uwe and Schmidt, Helena and Schmidt, Reinhold and Ben Schottker, and Schulz, Christina-Alexandra and Schupf, Nicole and Shaffer, Christian M. and Shi, Yuan and Smith, Albert V. and Smith, Blair H. and Soranzo, Nicole and Spracklen, Cassandra N. and Strauch, Konstantin and Stringham, Heather M. and Stumvoll, Michael and Svensson, Per O. and Szymczak, Silke and Tai, E-Shyong and Tajuddin, Salman M. and Tan, Nicholas Y. Q. and Taylor, Kent D. and Teren, Andrej and Tham, Yih-Chung and Thiery, Joachim and Thio, Chris H. L. and Thomsen, Hauke and Thorleifsson, Gudmar and Toniolo, Daniela and Tonjes, Anke and Tremblay, Johanne and Tzoulaki, Ioanna and Uitterlinden, Andre G. and Vaccargiu, Simona and Van Dam, Rob M. and Van der Harst, Pim and Van Duijn, Cornelia M. and Edward, Digna R. Velez and Verweij, Niek and Vogelezang, Suzanne and Volker, Uwe and Vollenweider, Peter and Waeber, Gerard and Waldenberger, Melanie and Wallentin, Lars and Wang, Ya Xing and Wang, Chaolong and Waterworth, Dawn M. and Bin Wei, Wen and White, Harvey and Whitfield, John B. and Wild, Sarah H. and Wilson, James F. and Wojczynski, Mary K. and Wong, Charlene and Wong, Tien-Yin and Xu, Liang and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Weihua and Zonderman, Alan B. and Rotter, Jerome I. and Bochud, Murielle and Psaty, Bruce M. and Vitart, Veronique and Wilson, James G. and Dehghan, Abbas and Parsa, Afshin and Chasman, Daniel I. and Ho, Kevin and Morris, Andrew P. and Devuyst, Olivier and Akilesh, Shreeram and Pendergrass, Sarah A. and Sim, Xueling and Boger, Carsten A. and Okada, Yukinori and Edwards, Todd L. and Snieder, Harold and Stefansson, Kari and Hung, Adriana M. and Heid, Iris M. and Scholz, Markus and Teumer, Alexander and Kottgen, Anna and Pattaro, Cristian}, title = {A catalog of genetic loci associated with kidney function from analyses of a million individuals}, series = {Nature genetics}, volume = {51}, journal = {Nature genetics}, number = {6}, publisher = {Nature Publ. Group}, address = {New York}, organization = {Lifelines COHort Study}, issn = {1061-4036}, doi = {10.1038/s41588-019-0407-x}, pages = {957 -- +}, year = {2019}, abstract = {Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.}, language = {en} } @article{BeaulieuBennettFouqueetal.2006, author = {Beaulieu, Jean-Philippe and Bennett, David P. and Fouqu{\´e}, Pascal and Williams, Andrew and Dominik, Martin and Jorgensen, Uffe Grae and Kubas, Daniel and Cassan, Arnaud and Coutures, Christian and Greenhill, John and Hill, Kym and Menzies, John and Sackett, Penny D. and Albrow, Michael D. and Brillant, Stephane and Caldwell, John A. R. and Calitz, Johannes Jacobus and Cook, Kem H. and Corrales Cosmeli, Esperanza de Santa Cecilia and Desort, Morgan and Dieters, Stefan and Dominis, Dijana and Donatowicz, Jadzia and Hoffman, Martie and Kane, Stephen R. and Marquette, Jean-Baptiste and Martin, Ralph and Meintjes, Pieter and Pollard, Karen R. and Sahu, Kailash C. and Vinter, Christian and Wambsganss, Joachim and Woller, Kristian and Horne, Keith and Steele, Iain and Bramich, Daniel M. and Burgdorf, Martin and Snodgrass, Colin and Bode, Mike and Udalski, Andr}, title = {Discovery of a cool planet of 5.5 Earth masses through gravitational microlensing}, issn = {0028-0836}, doi = {10.1038/Nature04441}, year = {2006}, abstract = {In the favoured core-accretion model of formation of planetary systems, solid planetesimals accumulate to build up planetary cores, which then accrete nebular gas if they are sufficiently massive. Around M-dwarf stars ( the most common stars in our Galaxy), this model favours the formation of Earth-mass (M+) to Neptune-mass planets with orbital radii of 1 to 10 astronomical units (AU), which is consistent with the small number of gas giant planets known to orbit M-dwarf host stars(1-4). More than 170 extrasolar planets have been discovered with a wide range of masses and orbital periods, but planets of Neptune's mass or less have not hitherto been detected at separations of more than 0.15 AU from normal stars. Here we report the discovery of a 5.5(-2.7)(+5.5)M(+) planetary companion at a separation of 2.6(- 0.6)(+1.5) AU from a 0.22(-0.11)(+0.21)M(.) M-dwarf star, where M-. refers to a solar mass. (We propose to name it OGLE- 2005-BLG-390Lb, indicating a planetary mass companion to the lens star of the microlensing event.) The mass is lower than that of GJ876d (ref. 5), although the error bars overlap. Our detection suggests that such cool, sub-Neptune-mass planets may be more common than gas giant planets, as predicted by the core accretion theory.}, language = {en} } @inproceedings{FroitzheimBergnerSchroederetal.2015, author = {Froitzheim, Manuel and Bergner, Nadine and Schroeder, Ulrik and Hurtienne, Dominik and Spannagel, Christian and Roderus, Simon and Wienkop, Uwe and Leonhardt, Thiemo and Kwiecien, Alexandra and Schmetz, Arno and Bellgardt, Martin and Naumann, Uwe and Weßels, Doris and Metzger, Christiane and L{\"a}ngrich, Matthias and Schulze, J{\"o}rg and Jakoblew, Marcel and Keil, Reinhard and Winkelnkemper, Felix and Engbring, Dieter and Klar, Tilman-Mathies and Kujath, Bertold and Sch{\"u}tze, Christopher and Fietkau, Julian and Kindsm{\"u}ller, Martin Christof and G{\"o}ttel, Timo and Bergner, Nadine and Taraschewski, Christian and Vosseberg, Karin and Czernik, Sofie and Erb, Ulrike and Vielhaber, Michael and Schlierkamp, Kathrin and Thurner, Veronika and Br{\"o}ker, Kathrin}, title = {HDI 2014 - Gestalten von {\"U}berg{\"a}ngen}, editor = {Forbrig, Peter and Magenheim, Johannes}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-313-8}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-74920}, pages = {186}, year = {2015}, abstract = {Die Tagung HDI 2014 in Freiburg zur Hochschuldidaktik der Informatik HDI wurde erneut vom Fachbereich Informatik und Ausbildung / Didaktik der Informatik (IAD) in der Gesellschaft f{\"u}r Informatik e. V. (GI) organisiert. Sie dient den Lehrenden der Informatik in Studieng{\"a}ngen an Hochschulen als Forum der Information und des Austauschs {\"u}ber neue didaktische Ans{\"a}tze und bildungspolitische Themen im Bereich der Hochschulausbildung aus der fachlichen Perspektive der Informatik. Die HDI 2014 ist nun bereits die sechste Ausgabe der HDI. F{\"u}r sie wurde das spezielle Motto „Gestalten und Meistern von {\"U}berg{\"a}ngen" gew{\"a}hlt. Damit soll ein besonderes Augenmerk auf die {\"U}berg{\"a}nge von Schule zum Studium, vom Bachelor zum Master, vom Studium zur Promotion oder vom Studium zur Arbeitswelt gelegt werden.}, language = {de} } @article{DenglerWagnerDembiczetal.2018, author = {Dengler, J{\"u}rgen and Wagner, Viktoria and Dembicz, Iwona and Garcia-Mijangos, Itziar and Naqinezhad, Alireza and Boch, Steffen and Chiarucci, Alessandro and Conradi, Timo and Filibeck, Goffredo and Guarino, Riccardo and Janisova, Monika and Steinbauer, Manuel J. and Acic, Svetlana and Acosta, Alicia T. R. and Akasaka, Munemitsu and Allers, Marc-Andre and Apostolova, Iva and Axmanova, Irena and Bakan, Branko and Baranova, Alina and Bardy-Durchhalter, Manfred and Bartha, Sandor and Baumann, Esther and Becker, Thomas and Becker, Ute and Belonovskaya, Elena and Bengtsson, Karin and Benito Alonso, Jose Luis and Berastegi, Asun and Bergamini, Ariel and Bonini, Ilaria and Bruun, Hans Henrik and Budzhak, Vasyl and Bueno, Alvaro and Antonio Campos, Juan and Cancellieri, Laura and Carboni, Marta and Chocarro, Cristina and Conti, Luisa and Czarniecka-Wiera, Marta and De Frenne, Pieter and Deak, Balazs and Didukh, Yakiv P. and Diekmann, Martin and Dolnik, Christian and Dupre, Cecilia and Ecker, Klaus and Ermakov, Nikolai and Erschbamer, Brigitta and Escudero, Adrian and Etayo, Javier and Fajmonova, Zuzana and Felde, Vivian A. and Fernandez Calzado, Maria Rosa and Finckh, Manfred and Fotiadis, Georgios and Fracchiolla, Mariano and Ganeva, Anna and Garcia-Magro, Daniel and Gavilan, Rosario G. and Germany, Markus and Giladi, Itamar and Gillet, Francois and Giusso del Galdo, Gian Pietro and Gonzalez, Jose M. and Grytnes, John-Arvid and Hajek, Michal and Hajkova, Petra and Helm, Aveliina and Herrera, Mercedes and Hettenbergerova, Eva and Hobohm, Carsten and Huellbusch, Elisabeth M. and Ingerpuu, Nele and Jandt, Ute and Jeltsch, Florian and Jensen, Kai and Jentsch, Anke and Jeschke, Michael and Jimenez-Alfaro, Borja and Kacki, Zygmunt and Kakinuma, Kaoru and Kapfer, Jutta and Kavgaci, Ali and Kelemen, Andras and Kiehl, Kathrin and Koyama, Asuka and Koyanagi, Tomoyo F. and Kozub, Lukasz and Kuzemko, Anna and Kyrkjeeide, Magni Olsen and Landi, Sara and Langer, Nancy and Lastrucci, Lorenzo and Lazzaro, Lorenzo and Lelli, Chiara and Leps, Jan and Loebel, Swantje and Luzuriaga, Arantzazu L. and Maccherini, Simona and Magnes, Martin and Malicki, Marek and Marceno, Corrado and Mardari, Constantin and Mauchamp, Leslie and May, Felix and Michelsen, Ottar and Mesa, Joaquin Molero and Molnar, Zsolt and Moysiyenko, Ivan Y. and Nakaga, Yuko K. and Natcheva, Rayna and Noroozi, Jalil and Pakeman, Robin J. and Palpurina, Salza and Partel, Meelis and Paetsch, Ricarda and Pauli, Harald and Pedashenko, Hristo and Peet, Robert K. and Pielech, Remigiusz and Pipenbaher, Natasa and Pirini, Chrisoula and Pleskova, Zuzana and Polyakova, Mariya A. and Prentice, Honor C. and Reinecke, Jennifer and Reitalu, Triin and Pilar Rodriguez-Rojo, Maria and Rolecek, Jan and Ronkin, Vladimir and Rosati, Leonardo and Rosen, Ejvind and Ruprecht, Eszter and Rusina, Solvita and Sabovljevic, Marko and Maria Sanchez, Ana and Savchenko, Galina and Schuhmacher, Oliver and Skornik, Sonja and Sperandii, Marta Gaia and Staniaszek-Kik, Monika and Stevanovic-Dajic, Zora and Stock, Marin and Suchrow, Sigrid and Sutcliffe, Laura M. E. and Swacha, Grzegorz and Sykes, Martin and Szabo, Anna and Talebi, Amir and Tanase, Catalin and Terzi, Massimo and Tolgyesi, Csaba and Torca, Marta and Torok, Peter and Tothmeresz, Bela and Tsarevskaya, Nadezda and Tsiripidis, Ioannis and Tzonev, Rossen and Ushimaru, Atushi and Valko, Orsolya and van der Maarel, Eddy and Vanneste, Thomas and Vashenyak, Iuliia and Vassilev, Kiril and Viciani, Daniele and Villar, Luis and Virtanen, Risto and Kosic, Ivana Vitasovic and Wang, Yun and Weiser, Frank and Went, Julia and Wesche, Karsten and White, Hannah and Winkler, Manuela and Zaniewski, Piotr T. and Zhang, Hui and Ziv, Yaron and Znamenskiy, Sergey and Biurrun, Idoia}, title = {GrassPlot - a database of multi-scale plant diversity in Palaearctic grasslands}, series = {Phytocoenologia}, volume = {48}, journal = {Phytocoenologia}, number = {3}, publisher = {Cramer}, address = {Stuttgart}, issn = {0340-269X}, doi = {10.1127/phyto/2018/0267}, pages = {331 -- 347}, year = {2018}, abstract = {GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). GrassPlot collects plot records (releves) from grasslands and other open habitats of the Palaearctic biogeographic realm. It focuses on precisely delimited plots of eight standard grain sizes (0.0001; 0.001;... 1,000 m(2)) and on nested-plot series with at least four different grain sizes. The usage of GrassPlot is regulated through Bylaws that intend to balance the interests of data contributors and data users. The current version (v. 1.00) contains data for approximately 170,000 plots of different sizes and 2,800 nested-plot series. The key components are richness data and metadata. However, most included datasets also encompass compositional data. About 14,000 plots have near-complete records of terricolous bryophytes and lichens in addition to vascular plants. At present, GrassPlot contains data from 36 countries throughout the Palaearctic, spread across elevational gradients and major grassland types. GrassPlot with its multi-scale and multi-taxon focus complements the larger international vegetationplot databases, such as the European Vegetation Archive (EVA) and the global database " sPlot". Its main aim is to facilitate studies on the scale-and taxon-dependency of biodiversity patterns and drivers along macroecological gradients. GrassPlot is a dynamic database and will expand through new data collection coordinated by the elected Governing Board. We invite researchers with suitable data to join GrassPlot. Researchers with project ideas addressable with GrassPlot data are welcome to submit proposals to the Governing Board.}, language = {en} } @article{TuckerBoehningGaeseFaganetal.2018, author = {Tucker, Marlee A. and Boehning-Gaese, Katrin and Fagan, William F. and Fryxell, John M. and Van Moorter, Bram and Alberts, Susan C. and Ali, Abdullahi H. and Allen, Andrew M. and Attias, Nina and Avgar, Tal and Bartlam-Brooks, Hattie and Bayarbaatar, Buuveibaatar and Belant, Jerrold L. and Bertassoni, Alessandra and Beyer, Dean and Bidner, Laura and van Beest, Floris M. and Blake, Stephen and Blaum, Niels and Bracis, Chloe and Brown, Danielle and de Bruyn, P. J. Nico and Cagnacci, Francesca and Calabrese, Justin M. and Camilo-Alves, Constanca and Chamaille-Jammes, Simon and Chiaradia, Andre and Davidson, Sarah C. and Dennis, Todd and DeStefano, Stephen and Diefenbach, Duane and Douglas-Hamilton, Iain and Fennessy, Julian and Fichtel, Claudia and Fiedler, Wolfgang and Fischer, Christina and Fischhoff, Ilya and Fleming, Christen H. and Ford, Adam T. and Fritz, Susanne A. and Gehr, Benedikt and Goheen, Jacob R. and Gurarie, Eliezer and Hebblewhite, Mark and Heurich, Marco and Hewison, A. J. Mark and Hof, Christian and Hurme, Edward and Isbell, Lynne A. and Janssen, Rene and Jeltsch, Florian and Kaczensky, Petra and Kane, Adam and Kappeler, Peter M. and Kauffman, Matthew and Kays, Roland and Kimuyu, Duncan and Koch, Flavia and Kranstauber, Bart and LaPoint, Scott and Leimgruber, Peter and Linnell, John D. C. and Lopez-Lopez, Pascual and Markham, A. Catherine and Mattisson, Jenny and Medici, Emilia Patricia and Mellone, Ugo and Merrill, Evelyn and Mourao, Guilherme de Miranda and Morato, Ronaldo G. and Morellet, Nicolas and Morrison, Thomas A. and Diaz-Munoz, Samuel L. and Mysterud, Atle and Nandintsetseg, Dejid and Nathan, Ran and Niamir, Aidin and Odden, John and Oliveira-Santos, Luiz Gustavo R. and Olson, Kirk A. and Patterson, Bruce D. and de Paula, Rogerio Cunha and Pedrotti, Luca and Reineking, Bjorn and Rimmler, Martin and Rogers, Tracey L. and Rolandsen, Christer Moe and Rosenberry, Christopher S. and Rubenstein, Daniel I. and Safi, Kamran and Said, Sonia and Sapir, Nir and Sawyer, Hall and Schmidt, Niels Martin and Selva, Nuria and Sergiel, Agnieszka and Shiilegdamba, Enkhtuvshin and Silva, Joao Paulo and Singh, Navinder and Solberg, Erling J. and Spiegel, Orr and Strand, Olav and Sundaresan, Siva and Ullmann, Wiebke and Voigt, Ulrich and Wall, Jake and Wattles, David and Wikelski, Martin and Wilmers, Christopher C. and Wilson, John W. and Wittemyer, George and Zieba, Filip and Zwijacz-Kozica, Tomasz and Mueller, Thomas}, title = {Moving in the Anthropocene}, series = {Science}, volume = {359}, journal = {Science}, number = {6374}, publisher = {American Assoc. for the Advancement of Science}, address = {Washington}, issn = {0036-8075}, doi = {10.1126/science.aam9712}, pages = {466 -- 469}, year = {2018}, abstract = {Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects not only population persistence but also ecosystem processes such as predator-prey interactions, nutrient cycling, and disease transmission.}, language = {en} } @book{HeimannNeitmannSchichetal.2007, author = {Heimann, Heinz-Dieter and Neitmann, Klaus and Schich, Winfried and Bauch, Martin and Franke, Ellen and Gahlbeck, Christian and Popp, Christian and Riedel, Peter}, title = {Brandenburgisches Klosterbuch : Handbuch der Kl{\"o}ster, Stifte und Kommenden bis zur Mitte des 16. Jahrhunderts}, series = {Brandenburgische Historische Studien}, volume = {14}, journal = {Brandenburgische Historische Studien}, publisher = {be.bra Wiss. Verl.}, address = {Berlin}, isbn = {978-3-937233-26-0}, pages = {1484 S.}, year = {2007}, language = {de} } @book{SchubarthZyllaNiproschkeetal.2014, author = {Schubarth, Wilfried and Zylla, Birgitta and Niproschke, Saskia and Guder, Petra and Sonnen, Bernd-R{\"u}deger and Kahl, Wolfgang and Groeger-Roth, Frederick and Kaeding, Peer and B{\"o}hm, Christian and Voigt, Jana and Sturzbecher, Dietmar and Kohlstruck, Michael and M{\"o}ller, Kurt and Rolfes, Manfred and Winter, Frank and Breitschwerdt, Michael and Kopp, Andrea and Hinze, Klaus and L{\"o}sel, Friedrich and Klindworth-Mohr, Antje and Madl, Martina and Dunand, Annelie and Schanzenb{\"a}cher, Stefan and Rump-R{\"a}uber, Michael and Roos, Alfred and Seidel, Andreas and Gr{\"o}ger, Ulli and Ulbricht, Juliane and Martin, Christian and Behrendt, Daniel}, title = {Nachhaltige Pr{\"a}vention von Kriminalit{\"a}t, Gewalt und Rechtsextremismus}, editor = {Schubarth, Wilfried}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-014-4}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-70537}, publisher = {Universit{\"a}t Potsdam}, pages = {449}, year = {2014}, abstract = {Was wird unter „nachhaltiger Pr{\"a}vention" in der Pr{\"a}ventionsforschung verstanden? Welche guten Beispiele f{\"u}r nachhaltige Pr{\"a}vention gibt es in der Praxis? Und v. a.: Wie l{\"a}sst sich Pr{\"a}vention in den verschiedenen Bereichen wie Kriminalit{\"a}t, Gewalt und Rechtsextremismus nachhaltig gestalten? Diesen Fragen will der vorliegende Sammelband nachgehen und damit der Pr{\"a}ventionsdebatte neue Impulse verleihen. Der Band will insbesondere die nationale sowie internationale Fachdebatte konstruktiv aufgreifen, Theorie und Praxis verbinden, „good practice" Beispiele darstellen sowie Perspektiven nachhaltiger Pr{\"a}vention aufzeigen. Mit diesem Themenspektrum richtet er sich sowohl an die Wissenschaft als auch an die Praxis sowie insgesamt an eine interessierte {\"O}ffentlichkeit.}, language = {de} } @article{GulbinsPalmadaReicheletal.2013, author = {Gulbins, Erich and Palmada, Monica and Reichel, Martin and Lueth, Anja and Boehmer, Christoph and Amato, Davide and Mueller, Christian P. and Tischbirek, Carsten H. and Groemer, Teja W. and Tabatabai, Ghazaleh and Becker, Katrin Anne and Tripal, Philipp and Staedtler, Sven and Ackermann, Teresa F. and van Brederode, Johannes and Alzheimer, Christian and Weller, Michael and Lang, Undine E. and Kleuser, Burkhard and Grassme, Heike and Kornhuber, Johannes}, title = {Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs}, series = {Nature medicine}, volume = {19}, journal = {Nature medicine}, number = {7}, publisher = {Nature Publ. Group}, address = {New York}, issn = {1078-8956}, doi = {10.1038/nm.3214}, pages = {934 -- +}, year = {2013}, abstract = {Major depression is a highly prevalent severe mood disorder that is treated with antidepressants. The molecular targets of antidepressants require definition. We investigated the role of the acid sphingomyelinase (Asm)-ceramide system as a target for antidepressants. Therapeutic concentrations of the antidepressants amitriptyline and fluoxetine reduced Asm activity and ceramide concentrations in the hippocampus, increased neuronal proliferation, maturation and survival and improved behavior in mouse models of stress-induced depression. Genetic Asm deficiency abrogated these effects. Mice overexpressing Asm, heterozygous for acid ceramidase, treated with blockers of ceramide metabolism or directly injected with C16 ceramide in the hippocampus had higher ceramide concentrations and lower rates of neuronal proliferation, maturation and survival compared with controls and showed depression-like behavior even in the absence of stress. The decrease of ceramide abundance achieved by antidepressant-mediated inhibition of Asm normalized these effects. Lowering ceramide abundance may thus be a central goal for the future development of antidepressants.}, language = {en} } @misc{ArnisonBibbBierbaumetal.2013, author = {Arnison, Paul G. and Bibb, Mervyn J. and Bierbaum, Gabriele and Bowers, Albert A. and Bugni, Tim S. and Bulaj, Grzegorz and Camarero, Julio A. and Campopiano, Dominic J. and Challis, Gregory L. and Clardy, Jon and Cotter, Paul D. and Craik, David J. and Dawson, Michael and Dittmann-Th{\"u}nemann, Elke and Donadio, Stefano and Dorrestein, Pieter C. and Entian, Karl-Dieter and Fischbach, Michael A. and Garavelli, John S. and Goeransson, Ulf and Gruber, Christian W. and Haft, Daniel H. and Hemscheidt, Thomas K. and Hertweck, Christian and Hill, Colin and Horswill, Alexander R. and Jaspars, Marcel and Kelly, Wendy L. and Klinman, Judith P. and Kuipers, Oscar P. and Link, A. James and Liu, Wen and Marahiel, Mohamed A. and Mitchell, Douglas A. and Moll, Gert N. and Moore, Bradley S. and Mueller, Rolf and Nair, Satish K. and Nes, Ingolf F. and Norris, Gillian E. and Olivera, Baldomero M. and Onaka, Hiroyasu and Patchett, Mark L. and Piel, J{\"o}rn and Reaney, Martin J. T. and Rebuffat, Sylvie and Ross, R. Paul and Sahl, Hans-Georg and Schmidt, Eric W. and Selsted, Michael E. and Severinov, Konstantin and Shen, Ben and Sivonen, Kaarina and Smith, Leif and Stein, Torsten and Suessmuth, Roderich D. and Tagg, John R. and Tang, Gong-Li and Truman, Andrew W. and Vederas, John C. and Walsh, Christopher T. and Walton, Jonathan D. and Wenzel, Silke C. and Willey, Joanne M. and van der Donk, Wilfred A.}, title = {Ribosomally synthesized and post-translationally modified peptide natural products overview and recommendations for a universal nomenclature}, series = {Natural product reports : a journal of current developments in bio-organic chemistry}, volume = {30}, journal = {Natural product reports : a journal of current developments in bio-organic chemistry}, number = {1}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {0265-0568}, doi = {10.1039/c2np20085f}, pages = {108 -- 160}, year = {2013}, abstract = {This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.}, language = {en} } @article{KunnusRajkovicSchrecketal.2012, author = {Kunnus, Kristjan and Rajkovic, Ivan and Schreck, Simon and Quevedo, Wilson and Eckert, Sebastian and Beye, Martin and Suljoti, Edlira and Weniger, Christian and Kalus, Christian and Gruebel, Sebastian and Scholz, Mirko and Nordlund, Dennis and Zhang, Wenkai and Hartsock, Robert W. and Gaffney, Kelly J. and Schlotter, William F. and Turner, Joshua J. and Kennedy, Brian and Hennies, Franz and Techert, Simone and Wernet, Philippe and F{\"o}hlisch, Alexander}, title = {A setup for resonant inelastic soft x-ray scattering on liquids at free electron laser light sources}, series = {Review of scientific instruments : a monthly journal devoted to scientific instruments, apparatus, and techniques}, volume = {83}, journal = {Review of scientific instruments : a monthly journal devoted to scientific instruments, apparatus, and techniques}, number = {12}, publisher = {American Institute of Physics}, address = {Melville}, issn = {0034-6748}, doi = {10.1063/1.4772685}, pages = {8}, year = {2012}, abstract = {We present a flexible and compact experimental setup that combines an in vacuum liquid jet with an x-ray emission spectrometer to enable static and femtosecond time-resolved resonant inelastic soft x-ray scattering (RIXS) measurements from liquids at free electron laser (FEL) light sources. We demonstrate the feasibility of this type of experiments with the measurements performed at the Linac Coherent Light Source FEL facility. At the FEL we observed changes in the RIXS spectra at high peak fluences which currently sets a limit to maximum attainable count rate at FELs. The setup presented here opens up new possibilities to study the structure and dynamics in liquids.}, language = {en} } @article{WangSmithSkroblinetal.2020, author = {Wang, Qiong and Smith, Joel A. and Skroblin, Dieter and Steele, Julian A. and Wolff, Christian Michael and Caprioglio, Pietro and Stolterfoht, Martin and K{\"o}bler, Hans and Turren-Cruz, Silver-Hamill and Li, Meng and Gollwitzer, Christian and Neher, Dieter and Abate, Antonio}, title = {Managing phase purities and crystal orientation for high-performance and photostable cesium lead halide perovskite solar cells}, series = {Solar RRL}, volume = {4}, journal = {Solar RRL}, number = {9}, publisher = {WILEY-VCH}, address = {Weinheim}, pages = {9}, year = {2020}, abstract = {Inorganic perovskites with cesium (Cs+) as the cation have great potential as photovoltaic materials if their phase purity and stability can be addressed. Herein, a series of inorganic perovskites is studied, and it is found that the power conversion efficiency of solar cells with compositions CsPbI1.8Br1.2, CsPbI2.0Br1.0, and CsPbI2.2Br0.8 exhibits a high dependence on the initial annealing step that is found to significantly affect the crystallization and texture behavior of the final perovskite film. At its optimized annealing temperature, CsPbI1.8Br1.2 exhibits a pure orthorhombic phase and only one crystal orientation of the (110) plane. Consequently, this allows for the best efficiency of up to 14.6\% and the longest operational lifetime, T-S80, of approximate to 300 h, averaged of over six solar cells, during the maximum power point tracking measurement under continuous light illumination and nitrogen atmosphere. This work provides essential progress on the enhancement of photovoltaic performance and stability of CsPbI3 - xBrx perovskite solar cells.}, language = {en} } @misc{WangSmithSkroblinetal.2020, author = {Wang, Qiong and Smith, Joel A. and Skroblin, Dieter and Steele, Julian A. and Wolff, Christian Michael and Caprioglio, Pietro and Stolterfoht, Martin and K{\"o}bler, Hans and Turren-Cruz, Silver-Hamill and Li, Meng and Gollwitzer, Christian and Neher, Dieter and Abate, Antonio}, title = {Managing phase purities and crystal orientation for high-performance and photostable cesium lead halide perovskite solar cells}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {9}, issn = {1866-8372}, doi = {10.25932/publishup-52537}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-525374}, pages = {11}, year = {2020}, abstract = {Inorganic perovskites with cesium (Cs+) as the cation have great potential as photovoltaic materials if their phase purity and stability can be addressed. Herein, a series of inorganic perovskites is studied, and it is found that the power conversion efficiency of solar cells with compositions CsPbI1.8Br1.2, CsPbI2.0Br1.0, and CsPbI2.2Br0.8 exhibits a high dependence on the initial annealing step that is found to significantly affect the crystallization and texture behavior of the final perovskite film. At its optimized annealing temperature, CsPbI1.8Br1.2 exhibits a pure orthorhombic phase and only one crystal orientation of the (110) plane. Consequently, this allows for the best efficiency of up to 14.6\% and the longest operational lifetime, T-S80, of approximate to 300 h, averaged of over six solar cells, during the maximum power point tracking measurement under continuous light illumination and nitrogen atmosphere. This work provides essential progress on the enhancement of photovoltaic performance and stability of CsPbI3 - xBrx perovskite solar cells.}, language = {en} } @misc{GorskiJungLietal.2020, author = {Gorski, Mathias and Jung, Bettina and Li, Yong and Matias-Garcia, Pamela R. and Wuttke, Matthias and Coassin, Stefan and Thio, Chris H. L. and Kleber, Marcus E. and Winkler, Thomas W. and Wanner, Veronika and Chai, Jin-Fang and Chu, Audrey Y. and Cocca, Massimiliano and Feitosa, Mary F. and Ghasemi, Sahar and Hoppmann, Anselm and Horn, Katrin and Li, Man and Nutile, Teresa and Scholz, Markus and Sieber, Karsten B. and Teumer, Alexander and Tin, Adrienne and Wang, Judy and Tayo, Bamidele O. and Ahluwalia, Tarunveer S. and Almgren, Peter and Bakker, Stephan J. L. and Banas, Bernhard and Bansal, Nisha and Biggs, Mary L. and Boerwinkle, Eric and B{\"o}ttinger, Erwin and Brenner, Hermann and Carroll, Robert J. and Chalmers, John and Chee, Miao-Li and Chee, Miao-Ling and Cheng, Ching-Yu and Coresh, Josef and de Borst, Martin H. and Degenhardt, Frauke and Eckardt, Kai-Uwe and Endlich, Karlhans and Franke, Andre and Freitag-Wolf, Sandra and Gampawar, Piyush and Gansevoort, Ron T. and Ghanbari, Mohsen and Gieger, Christian and Hamet, Pavel and Ho, Kevin and Hofer, Edith and Holleczek, Bernd and Foo, Valencia Hui Xian and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Josyula, Navya Shilpa and Kahonen, Mika and Khor, Chiea-Chuen and Koenig, Wolfgang and Kramer, Holly and Kraemer, Bernhard K. and Kuehnel, Brigitte and Lange, Leslie A. and Lehtimaki, Terho and Lieb, Wolfgang and Loos, Ruth J. F. and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Milaneschi, Yuri and Mishra, Pashupati P. and Mononen, Nina and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and O'Donoghue, Michelle L. and Orho-Melander, Marju and Pendergrass, Sarah A. and Penninx, Brenda W. J. H. and Preuss, Michael H. and Psaty, Bruce M. and Raffield, Laura M. and Raitakari, Olli T. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Rosenkranz, Alexander R. and Rossing, Peter and Rotter, Jerome and Sabanayagam, Charumathi and Schmidt, Helena and Schmidt, Reinhold and Schoettker, Ben and Schulz, Christina-Alexandra and Sedaghat, Sanaz and Shaffer, Christian M. and Strauch, Konstantin and Szymczak, Silke and Taylor, Kent D. and Tremblay, Johanne and Chaker, Layal and van der Harst, Pim and van der Most, Peter J. and Verweij, Niek and Voelker, Uwe and Waldenberger, Melanie and Wallentin, Lars and Waterworth, Dawn M. and White, Harvey D. and Wilson, James G. and Wong, Tien-Yin and Woodward, Mark and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Yan and Snieder, Harold and Wanner, Christoph and Boger, Carsten A. and Kottgen, Anna and Kronenberg, Florian and Pattaro, Cristian and Heid, Iris M.}, title = {Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Reihe der Digital Engineering Fakult{\"a}t}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Reihe der Digital Engineering Fakult{\"a}t}, number = {19}, doi = {10.25932/publishup-56537}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-565379}, pages = {14}, year = {2020}, abstract = {Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25\% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95\% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.}, language = {en} } @article{GorskiJungLietal.2020, author = {Gorski, Mathias and Jung, Bettina and Li, Yong and Matias-Garcia, Pamela R. and Wuttke, Matthias and Coassin, Stefan and Thio, Chris H. L. and Kleber, Marcus E. and Winkler, Thomas W. and Wanner, Veronika and Chai, Jin-Fang and Chu, Audrey Y. and Cocca, Massimiliano and Feitosa, Mary F. and Ghasemi, Sahar and Hoppmann, Anselm and Horn, Katrin and Li, Man and Nutile, Teresa and Scholz, Markus and Sieber, Karsten B. and Teumer, Alexander and Tin, Adrienne and Wang, Judy and Tayo, Bamidele O. and Ahluwalia, Tarunveer S. and Almgren, Peter and Bakker, Stephan J. L. and Banas, Bernhard and Bansal, Nisha and Biggs, Mary L. and Boerwinkle, Eric and B{\"o}ttinger, Erwin and Brenner, Hermann and Carroll, Robert J. and Chalmers, John and Chee, Miao-Li and Chee, Miao-Ling and Cheng, Ching-Yu and Coresh, Josef and de Borst, Martin H. and Degenhardt, Frauke and Eckardt, Kai-Uwe and Endlich, Karlhans and Franke, Andre and Freitag-Wolf, Sandra and Gampawar, Piyush and Gansevoort, Ron T. and Ghanbari, Mohsen and Gieger, Christian and Hamet, Pavel and Ho, Kevin and Hofer, Edith and Holleczek, Bernd and Foo, Valencia Hui Xian and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Josyula, Navya Shilpa and Kahonen, Mika and Khor, Chiea-Chuen and Koenig, Wolfgang and Kramer, Holly and Kraemer, Bernhard K. and Kuehnel, Brigitte and Lange, Leslie A. and Lehtimaki, Terho and Lieb, Wolfgang and Loos, Ruth J. F. and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Milaneschi, Yuri and Mishra, Pashupati P. and Mononen, Nina and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and O'Donoghue, Michelle L. and Orho-Melander, Marju and Pendergrass, Sarah A. and Penninx, Brenda W. J. H. and Preuss, Michael H. and Psaty, Bruce M. and Raffield, Laura M. and Raitakari, Olli T. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Rosenkranz, Alexander R. and Rossing, Peter and Rotter, Jerome and Sabanayagam, Charumathi and Schmidt, Helena and Schmidt, Reinhold and Schoettker, Ben and Schulz, Christina-Alexandra and Sedaghat, Sanaz and Shaffer, Christian M. and Strauch, Konstantin and Szymczak, Silke and Taylor, Kent D. and Tremblay, Johanne and Chaker, Layal and van der Harst, Pim and van der Most, Peter J. and Verweij, Niek and Voelker, Uwe and Waldenberger, Melanie and Wallentin, Lars and Waterworth, Dawn M. and White, Harvey D. and Wilson, James G. and Wong, Tien-Yin and Woodward, Mark and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Yan and Snieder, Harold and Wanner, Christoph and Boger, Carsten A. and Kottgen, Anna and Kronenberg, Florian and Pattaro, Cristian and Heid, Iris M.}, title = {Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline}, series = {Kidney international : official journal of the International Society of Nephrology}, volume = {99}, journal = {Kidney international : official journal of the International Society of Nephrology}, number = {4}, publisher = {Elsevier}, address = {New York}, organization = {Lifelines Cohort Study
Regeneron Genetics Ctr}, issn = {0085-2538}, doi = {10.1016/j.kint.2020.09.030}, pages = {926 -- 939}, year = {2020}, abstract = {Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25\% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95\% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.}, language = {en} } @book{BarceloEdelmayerGuichardetal.2004, author = {Barcel{\´o}, Pedro and Edelmayer, Friedrich and Guichard, Pierre and Herold-Schmidt, Hedwig and Kleinmann, Hans-Otto and Martin, Jose L.Martin and Schmidt, Peer and Windler, Christian}, title = {Kleine Geschichte Spaniens}, series = {Universal-Bibliothek}, volume = {17039}, journal = {Universal-Bibliothek}, editor = {Schmidt, Peer}, publisher = {Reclam}, address = {Stuttgart}, isbn = {3-15-017039-7}, pages = {555 S.}, year = {2004}, language = {de} } @misc{HetenyiMolinariClintonetal.2018, author = {Hetenyi, Gyorgy and Molinari, Irene and Clinton, John and Bokelmann, Gotz and Bondar, Istvan and Crawford, Wayne C. and Dessa, Jean-Xavier and Doubre, Cecile and Friederich, Wolfgang and Fuchs, Florian and Giardini, Domenico and Graczer, Zoltan and Handy, Mark R. and Herak, Marijan and Jia, Yan and Kissling, Edi and Kopp, Heidrun and Korn, Michael and Margheriti, Lucia and Meier, Thomas and Mucciarelli, Marco and Paul, Anne and Pesaresi, Damiano and Piromallo, Claudia and Plenefisch, Thomas and Plomerova, Jaroslava and Ritter, Joachim and Rumpker, Georg and Sipka, Vesna and Spallarossa, Daniele and Thomas, Christine and Tilmann, Frederik and Wassermann, Joachim and Weber, Michael and Weber, Zoltan and Wesztergom, Viktor and Zivcic, Mladen and Abreu, Rafael and Allegretti, Ivo and Apoloner, Maria-Theresia and Aubert, Coralie and Besancon, Simon and de Berc, Maxime Bes and Brunel, Didier and Capello, Marco and Carman, Martina and Cavaliere, Adriano and Cheze, Jerome and Chiarabba, Claudio and Cougoulat, Glenn and Cristiano, Luigia and Czifra, Tibor and Danesi, Stefania and Daniel, Romuald and Dannowski, Anke and Dasovic, Iva and Deschamps, Anne and Egdorf, Sven and Fiket, Tomislav and Fischer, Kasper and Funke, Sigward and Govoni, Aladino and Groschl, Gidera and Heimers, Stefan and Heit, Ben and Herak, Davorka and Huber, Johann and Jaric, Dejan and Jedlicka, Petr and Jund, Helene and Klingen, Stefan and Klotz, Bernhard and Kolinsky, Petr and Kotek, Josef and Kuhne, Lothar and Kuk, Kreso and Lange, Dietrich and Loos, Jurgen and Lovati, Sara and Malengros, Deny and Maron, Christophe and Martin, Xavier and Massa, Marco and Mazzarini, Francesco and Metral, Laurent and Moretti, Milena and Munzarova, Helena and Nardi, Anna and Pahor, Jurij and Pequegnat, Catherine and Petersen, Florian and Piccinini, Davide and Pondrelli, Silvia and Prevolnik, Snjezan and Racine, Roman and Regnier, Marc and Reiss, Miriam and Salimbeni, Simone and Santulin, Marco and Scherer, Werner and Schippkus, Sven and Schulte-Kortnack, Detlef and Solarino, Stefano and Spieker, Kathrin and Stipcevic, Josip and Strollo, Angelo and Sule, Balint and Szanyi, Gyongyver and Szucs, Eszter and Thorwart, Martin and Ueding, Stefan and Vallocchia, Massimiliano and Vecsey, Ludek and Voigt, Rene and Weidle, Christian and Weyland, Gauthier and Wiemer, Stefan and Wolf, Felix and Wolyniec, David and Zieke, Thomas}, title = {The AlpArray seismic network}, series = {Surveys in Geophysics}, volume = {39}, journal = {Surveys in Geophysics}, number = {5}, publisher = {Springer}, address = {Dordrecht}, organization = {ETHZ SED Elect Lab AlpArray Seismic Network Team AlpArray OBS Cruise Crew AlpArray Working Grp}, issn = {0169-3298}, doi = {10.1007/s10712-018-9472-4}, pages = {1009 -- 1033}, year = {2018}, abstract = {The AlpArray programme is a multinational, European consortium to advance our understanding of orogenesis and its relationship to mantle dynamics, plate reorganizations, surface processes and seismic hazard in the Alps-Apennines-Carpathians-Dinarides orogenic system. The AlpArray Seismic Network has been deployed with contributions from 36 institutions from 11 countries to map physical properties of the lithosphere and asthenosphere in 3D and thus to obtain new, high-resolution geophysical images of structures from the surface down to the base of the mantle transition zone. With over 600 broadband stations operated for 2 years, this seismic experiment is one of the largest simultaneously operated seismological networks in the academic domain, employing hexagonal coverage with station spacing at less than 52 km. This dense and regularly spaced experiment is made possible by the coordinated coeval deployment of temporary stations from numerous national pools, including ocean-bottom seismometers, which were funded by different national agencies. They combine with permanent networks, which also required the cooperation of many different operators. Together these stations ultimately fill coverage gaps. Following a short overview of previous large-scale seismological experiments in the Alpine region, we here present the goals, construction, deployment, characteristics and data management of the AlpArray Seismic Network, which will provide data that is expected to be unprecedented in quality to image the complex Alpine mountains at depth.}, language = {en} } @article{PenoneAllanSoliveresetal.2019, author = {Penone, Caterina and Allan, Eric and Soliveres, Santiago and Felipe-Lucia, Maria R. and Gossner, Martin M. and Seibold, Sebastian and Simons, Nadja K. and Schall, Peter and van der Plas, Fons and Manning, Peter and Manzanedo, Ruben D. and Boch, Steffen and Prati, Daniel and Ammer, Christian and Bauhus, Juergen and Buscot, Francois and Ehbrecht, Martin and Goldmann, Kezia and Jung, Kirsten and Mueller, Joerg and Mueller, Joerg C. and Pena, Rodica and Polle, Andrea and Renner, Swen C. and Ruess, Liliane and Schoenig, Ingo and Schrumpf, Marion and Solly, Emily F. and Tschapka, Marco and Weisser, Wolfgang W. and Wubet, Tesfaye and Fischer, Markus}, title = {Specialisation and diversity of multiple trophic groups are promoted by different forest features}, series = {Ecology letters}, volume = {22}, journal = {Ecology letters}, number = {1}, publisher = {Wiley}, address = {Hoboken}, issn = {1461-023X}, doi = {10.1111/ele.13182}, pages = {170 -- 180}, year = {2019}, abstract = {While forest management strongly influences biodiversity, it remains unclear how the structural and compositional changes caused by management affect different community dimensions (e.g. richness, specialisation, abundance or completeness) and how this differs between taxa. We assessed the effects of nine forest features (representing stand structure, heterogeneity and tree composition) on thirteen above- and belowground trophic groups of plants, animals, fungi and bacteria in 150 temperate forest plots differing in their management type. Canopy cover decreased light resources, which increased community specialisation but reduced overall diversity and abundance. Features increasing resource types and diversifying microhabitats (admixing of oaks and conifers) were important and mostly affected richness. Belowground groups responded differently to those aboveground and had weaker responses to most forest features. Our results show that we need to consider forest features rather than broad management types and highlight the importance of considering several groups and community dimensions to better inform conservation.}, language = {en} } @article{RuzanskiSmirnovaRejzeketal.2013, author = {Ruzanski, Christian and Smirnova, Julia and Rejzek, Martin and Cockburn, Darrell and Pedersen, Henriette L. and Pike, Marilyn and Willats, William G. T. and Svensson, Birte and Steup, Martin and Ebenh{\"o}h, Oliver and Smith, Alison M. and Field, Robert A.}, title = {A bacterial glucanotransferase can replace the complex maltose metabolism required for starch to sucrose conversion in leaves at night}, series = {The journal of biological chemistry}, volume = {288}, journal = {The journal of biological chemistry}, number = {40}, publisher = {American Society for Biochemistry and Molecular Biology}, address = {Bethesda}, issn = {0021-9258}, doi = {10.1074/jbc.M113.497867}, pages = {28581 -- 28598}, year = {2013}, abstract = {Controlled conversion of leaf starch to sucrose at night is essential for the normal growth of Arabidopsis. The conversion involves the cytosolic metabolism of maltose to hexose phosphates via an unusual, multidomain protein with 4-glucanotransferase activity, DPE2, believed to transfer glucosyl moieties to a complex heteroglycan prior to their conversion to hexose phosphate via a cytosolic phosphorylase. The significance of this complex pathway is unclear; conversion of maltose to hexose phosphate in bacteria proceeds via a more typical 4-glucanotransferase that does not require a heteroglycan acceptor. It has recently been suggested that DPE2 generates a heterogeneous series of terminal glucan chains on the heteroglycan that acts as a glucosyl buffer to ensure a constant rate of sucrose synthesis in the leaf at night. Alternatively, DPE2 and/or the heteroglycan may have specific properties important for their function in the plant. To distinguish between these ideas, we compared the properties of DPE2 with those of the Escherichia coli glucanotransferase MalQ. We found that MalQ cannot use the plant heteroglycan as an acceptor for glucosyl transfer. However, experimental and modeling approaches suggested that it can potentially generate a glucosyl buffer between maltose and hexose phosphate because, unlike DPE2, it can generate polydisperse malto-oligosaccharides from maltose. Consistent with this suggestion, MalQ is capable of restoring an essentially wild-type phenotype when expressed in mutant Arabidopsis plants lacking DPE2. In light of these findings, we discuss the possible evolutionary origins of the complex DPE2-heteroglycan pathway.}, language = {en} } @article{KroescheCrescenziHoffbaueretal.1994, author = {Kr{\"o}sche, Christian and Crescenzi, Orlando and Hoffbauer, Wilfried and Jansen, Martin and Napolitano, Alessandra and Prota, Guiseppe and Peter, Martin G.}, title = {Synthesis of dopamines labelled with 13C in the alpha- or beta-side chain positions, and their application for structure studies on melanins by solid state NMR spectroscopy}, year = {1994}, language = {en} } @misc{AbramowskiAharonianBenkhalietal.2015, author = {Abramowski, Attila and Aharonian, Felix A. and Benkhali, Faical Ait and Akhperjanian, A. G. and Ang{\"u}ner, Ekrem Oǧuzhan and Backes, Michael and Balenderan, Shangkari and Balzer, Arnim and Barnacka, Anna and Becherini, Yvonne and Tjus, Julia Becker and Berge, David and Bernhard, Sabrina and Bernl{\"o}hr, Konrad and Birsin, E. and Biteau, Jonathan and B{\"o}ttcher, Markus and Boisson, Catherine and Bolmont, J. and Bordas, Pol and Bregeon, Johan and Brun, Francois and Brun, Pierre and Bryan, Mark and Bulik, Tomasz and Carrigan, Svenja and Casanova, Sabrina and Chadwick, Paula M. and Chakraborty, Nachiketa and Chalme-Calvet, R. and Chaves, Ryan C. G. and Chretien, M. and Colafrancesco, Sergio and Cologna, Gabriele and Conrad, Jan and Couturier, Claire and Cui, Yudong and Davids, Isak Delberth and Degrange, Bernhard and Deil, Christoph and deWilt, P. and Djannati-Ata{\"i}, A. and Domainko, Wilfried and Donath, Axel and Dubus, G. and Dutson, K. and Dyks, J. and Dyrda, M. and Edwards, Tanya and Egberts, Kathrin and Eger, Peter and Espigat, P. and Farnier, C. and Fegan, Stephen and Feinstein, Fabrice and Fernandes, Milton Virgilio and Fernandez, Diane and Fiasson, A. and Fontaine, Gerard and F{\"o}rster, Andreas and Fuessling, M. and Gabici, S. and Gajdus, M. and Gallant, Yves A. and Garrigoux, Tania and Giavitto, G. and Giebels, Berrie and Glicenstein, Jean-Francois and Gottschall, Daniel and Grondin, M. -H. and Grudzinska, M. and Hadasch, Daniela and Haeffner, S. and Hahn, Joachim and Harris, Jonathan and Heinzelmann, G{\"o}tz and Henri, G. and Hermann, German and Hervet, O. and Hillert, Andreas and Hinton, James Anthony and Hofmann, Werner and Hofverberg, Petter and Holler, Markus and Horns, Dieter and Ivascenko, Alex and Jacholkowska, A. and Jahn, C. and Jamrozy, Marek and Janiak, M. and Jankowsky, F. and Jung-Richardt, I. and Kastendieck, Max Anton and Katarzynski, K. and Katz, U. and Kaufmann, S. and Khelifi, B. and Kieffer, Michel and Klepser, S. and Klochkov, Dmitry and Kluzniak, W. and Kolitzus, David and Komin, Nu and Kosack, Karl and Krakau, Steffen and Krayzel, F. and Krueger, Pat P. and Laffon, H. and Lamanna, G. and Lefaucheur, J. and Lefranc, Valentin and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Lohse, Thomas and Lopatin, A. and Lu, Chia-Chun and Marandon, Vincent and Marcowith, Alexandre and Marx, Ramin and Maurin, G. and Maxted, Nigel and Mayer, Michael and McComb, T. J. Lowry and Mehault, J. and Meintjes, P. J. and Menzler, Ulf and Meyer, M. and Mitchell, Alison M. W. and Moderski, R. and Mohamed, M. and Mora, K. and Moulin, Emmanuel and Murach, Thomas and de Naurois, Mathieu and Niemiec, J. and Nolan, Sam J. and Oakes, Louise and Odaka, Hirokazu and Ohm, S. and Optiz, Bj{\"o}rn and Ostrowski, Michal and Oya, I. and Panter, Michael and Parsons, R. Daniel and Arribas, M. Paz and Pekeur, Nikki W. and Pelletier, G. and Petrucci, P. -O. and Peyaud, B. and Pita, S. and Poon, Helen and P{\"u}hlhofer, Gerd and Punch, M. and Quirrenbach, A. and Raab, S. and Reichardt, I. and Reimer, Anita and Reimer, Olaf and Renaud, Metz and de los Reyes, Raquel and Rieger, Frank and Romoli, C. and Rosier-Lees, S. and Rowell, G. and Rudak, B. and Rulten, C. B. and Sahakian, Vardan and Salek, D. and Sanchez, David M. and Santangelo, Andrea and Schlickeiser, Reinhard and Schuessler, F. and Schulz, A. and Schwanke, Ullrich and Schwarzburg, S. and Schwemmer, S. and Sol, H. and Spanier, Felix and Spengler, G. and Spies, Franziska and Stawarz, Lukasz and Steenkamp, Riaan and Stegmann, Christian and Stinzing, F. and Stycz, K. and Sushch, Iurii and Tavernet, J. -P. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tluczykont, Martin and Trichard, C. and Valerius, K. and van Eldik, C. and van Soelen, B. and Vasileiadis, Georges and Veh, J. and Venter, Christo and Viana, Aion and Vincent, P. and Vink, Jacco and V{\"o}lk, Heinrich J. and Volpe, Francesca and Vorster, Martine and Vuillaume, T. and Wagner, S. J. and Wagner, P. and Wagner, R. M. and Ward, Martin and Weidinger, Matthias and Weitzel, Quirin and White, R. and Wierzcholska, A. and Willmann, P. and Woernlein, A. and Wouters, D. and Yang, Ruizhi and Zabalza, Victor and Zaborov, Dmitry and Zacharias, M. and Zdziarski, A. A. and Zech, Alraune and Zechlin, Hannes -S.}, title = {H.E.S.S. detection of TeV emission from the interaction region between the supernova remnant G349.7+0.2 and a molecular cloud (vol 574, A100, 2015)}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {580}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, organization = {HESS Collaboration}, issn = {1432-0746}, doi = {10.1051/0004-6361/201425070e}, pages = {2}, year = {2015}, language = {en} } @article{PohankovaHlavinkaKersebaumetal.2022, author = {Pohankov{\´a}, Eva and Hlavinka, Petr and Kersebaum, Kurt-Christian and Rodr{\´i}guez, Alfredo and Balek, Jan and Bednař{\´i}k, Martin and Dubrovsk{\´y}, Martin and Gobin, Anne and Hoogenboom, Gerrit and Moriondo, Marco and Nendel, Claas and Olesen, J{\o}rgen E. E. and R{\"o}tter, Reimund Paul and Ruiz-Ramos, Margarita and Shelia, Vakhtang and Stella, Tommaso and Hoffmann, Munir Paul and Tak{\´a}č, Jozef and Eitzinger, Josef and Dibari, Camilla and Ferrise, Roberto and Bl{\´a}hov{\´a}, Monika and Trnka, Miroslav}, title = {Expected effects of climate change on the production and water use of crop rotation management reproduced by crop model ensemble for Czech Republic sites}, series = {European journal of agronomy}, volume = {134}, journal = {European journal of agronomy}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1161-0301}, doi = {10.1016/j.eja.2021.126446}, pages = {27}, year = {2022}, abstract = {Crop rotation, fertilization and residue management affect the water balance and crop production and can lead to different sensitivities to climate change. To assess the impacts of climate change on crop rotations (CRs), the crop model ensemble (APSIM,AQUACROP, CROPSYST, DAISY, DSSAT, HERMES, MONICA) was used. The yields and water balance of two CRs with the same set of crops (winter wheat, silage maize, spring barley and winter rape) in a continuous transient run from 1961 to 2080 were simulated. CR1 was without cover crops and without manure application. Straw after the harvest was exported from the fields. CR2 included cover crops, manure application and crop residue retention left on field. Simulations were performed using two soil types (Chernozem, Cambisol) within three sites in the Czech Republic, which represent temperature and precipitation gradients for crops in Central Europe. For the description of future climatic conditions, seven climate scenarios were used. Six of them had increasing CO \& nbsp;concentrations according RCP 8.5, one had no CO2 increase in the future. The output of an ensemble expected higher productivity by 0.82 t/ha/year and 2.04 t/ha/year for yields and aboveground biomass in the future (2051-2080). However, if the direct effect of a CO2 increase is not considered, the average yields for lowlands will be lower. Compared to CR1, CR2 showed higher average yields of 1.26 t/ha/year for current climatic conditions and 1.41 t/ha/year for future climatic conditions. For the majority of climate change scenarios, the crop model ensemble agrees on the projected yield increase in C3 crops in the future for CR2 but not for CR1. Higher agreement for future yield increases was found for Chernozem, while for Cambisol, lower yields under dry climate scenarios are expected. For silage maize, changes in simulated yields depend on locality. If the same hybrid will be used in the future, then yield reductions should be expected within lower altitudes. The results indicate the potential for higher biomass production from cover crops, but CR2 is associated with almost 120 mm higher evapotranspiration compared to that of CR1 over a 5-year cycle for lowland stations in the future, which in the case of the rainfed agriculture could affect the long-term soil water balance. This could affect groundwater replenishment, especially for locations with fine textured soils, although the findings of this study highlight the potential for the soil water-holding capacity to buffer against the adverse weather conditions.}, language = {en} } @unpublished{AcharyaActisAghajanietal.2013, author = {Acharya, B. S. and Actis, M. and Aghajani, T. and Agnetta, G. and Aguilar, J. and Aharonian, Felix A. and Ajello, M. and Akhperjanian, A. G. and Alcubierre, M. and Aleksic, J. and Alfaro, R. and Aliu, E. and Allafort, A. J. and Allan, D. and Allekotte, I. and Amato, E. and Anderson, J. and Ang{\"u}ner, Ekrem Oǧuzhan and Antonelli, L. A. and Antoranz, P. and Aravantinos, A. and Arlen, T. and Armstrong, T. and Arnaldi, H. and Arrabito, L. and Asano, K. and Ashton, T. and Asorey, H. G. and Awane, Y. and Baba, H. and Babic, A. and Baby, N. and Baehr, J. and Bais, A. and Baixeras, C. and Bajtlik, S. and Balbo, M. and Balis, D. and Balkowski, C. and Bamba, A. and Bandiera, R. and Barber, A. and Barbier, C. and Barcelo, M. and Barnacka, Anna and Barnstedt, J{\"u}rgen and Barres de Almeida, U. and Barrio, J. A. and Basili, A. and Basso, S. and Bastieri, D. and Bauer, C. and Baushev, Anton N. and Becerra Gonzalez, J. and Becherini, Yvonne and Bechtol, K. C. and Tjus, J. Becker and Beckmann, Volker and Bednarek, W. and Behera, B. and Belluso, M. and Benbow, W. and Berdugo, J. and Berger, K. and Bernard, F. and Bernardino, T. and Bernl{\"o}hr, K. and Bhat, N. and Bhattacharyya, S. and Bigongiari, C. and Biland, A. and Billotta, S. and Bird, T. and Birsin, E. and Bissaldi, E. and Biteau, Jonathan and Bitossi, M. and Blake, S. and Blanch Bigas, O. and Blasi, P. and Bobkov, A. A. and Boccone, V. and Boettcher, Markus and Bogacz, L. and Bogart, J. and Bogdan, M. and Boisson, Catherine and Boix Gargallo, J. and Bolmont, J. and Bonanno, G. and Bonardi, A. and Bonev, T. and Bonifacio, P. and Bonnoli, G. and Bordas, Pol and Borgland, A. W. and Borkowski, Janett and Bose, R. and Botner, O. and Bottani, A. and Bouchet, L. and Bourgeat, M. and Boutonnet, C. and Bouvier, A. and Brau-Nogue, S. and Braun, I. and Bretz, T. and Briggs, M. S. and Bringmann, T. and Brook, P. and Brun, Pierre and Brunetti, L. and Buanes, T. and Buckley, J. H. and Buehler, R. and Bugaev, V. and Bulgarelli, A. and Bulik, Tomasz and Busetto, G. and Buson, S. and Byrum, K. and Cailles, M. and Cameron, R. A. and Camprecios, J. and Canestrari, R. and Cantu, S. and Capalbi, M. and Caraveo, P. A. and Carmona, E. and Carosi, A. and Carr, John and Carton, P. H. and Casanova, Sabrina and Casiraghi, M. and Catalano, O. and Cavazzani, S. and Cazaux, S. and Cerruti, M. and Chabanne, E. and Chadwick, Paula M. and Champion, C. and Chen, Andrew and Chiang, J. and Chiappetti, L. and Chikawa, M. and Chitnis, V. R. and Chollet, F. and Chudoba, J. and Cieslar, M. and Cillis, A. N. and Cohen-Tanugi, J. and Colafrancesco, Sergio and Colin, P. and Calome, J. and Colonges, S. and Compin, M. and Conconi, P. and Conforti, V. and Connaughton, V. and Conrad, Jan and Contreras, J. L. and Coppi, P. and Corona, P. and Corti, D. and Cortina, J. and Cossio, L. and Costantini, H. and Cotter, G. and Courty, B. and Couturier, S. and Covino, S. and Crimi, G. and Criswell, S. J. and Croston, J. and Cusumano, G. and Dafonseca, M. and Dale, O. and Daniel, M. and Darling, J. and Davids, I. and Dazzi, F. and De Angelis, A. and De Caprio, V. and De Frondat, F. and de Gouveia Dal Pino, E. M. and de la Calle, I. and De La Vega, G. A. and Lopez, R. de los Reyes and De Lotto, B. and De Luca, A. and de Mello Neto, J. R. T. and de Naurois, M. and de Oliveira, Y. and de Ona Wilhelmi, E. and de Souza, V. and Decerprit, G. and Decock, G. and Deil, C. and Delagnes, E. and Deleglise, G. and Delgado, C. and Della Volpe, D. and Demange, P. and Depaola, G. and Dettlaff, A. and Di Paola, A. and Di Pierro, F. and Diaz, C. and Dick, J. and Dickherber, R. and Dickinson, H. and Diez-Blanco, V. and Digel, S. and Dimitrov, D. and Disset, G. and Djannati-Ata{\"i}, A. and Doert, M. and Dohmke, M. and Domainko, W. and Prester, Dijana Dominis and Donat, A. and Dorner, D. and Doro, M. and Dournaux, J-L. and Drake, G. and Dravins, D. and Drury, L. and Dubois, F. and Dubois, R. and Dubus, G. and Dufour, C. and Dumas, D. and Dumm, J. and Durand, D. and Dyks, J. and Dyrda, M. and Ebr, J. and Edy, E. and Egberts, Kathrin and Eger, P. and Einecke, S. and Eleftheriadis, C. and Elles, S. and Emmanoulopoulos, D. and Engelhaupt, D. and Enomoto, R. and Ernenwein, J-P and Errando, M. and Etchegoyen, A. and Evans, P. and Falcone, A. and Fantinel, D. and Farakos, K. and Farnier, C. and Fasola, G. and Favill, B. and Fede, E. and Federici, S. and Fegan, S. and Feinstein, F. and Ferenc, D. and Ferrando, P. and Fesquet, M. and Fiasson, A. and Fillin-Martino, E. and Fink, D. and Finley, C. and Finley, J. P. and Fiorini, M. and Firpo Curcoll, R. and Flores, H. and Florin, D. and Focke, W. and Foehr, C. and Fokitis, E. and Font, L. and Fontaine, G. and Fornasa, M. and Foerster, A. and Fortson, L. and Fouque, N. and Franckowiak, A. and Fransson, C. and Fraser, G. and Frei, R. and Albuquerque, I. F. M. and Fresnillo, L. and Fruck, C. and Fujita, Y. and Fukazawa, Y. and Fukui, Y. and Funk, S. and Gaebele, W. and Gabici, S. and Gabriele, R. and Gadola, A. and Galante, N. and Gall, D. and Gallant, Y. and Gamez-Garcia, J. and Garcia, B. and Garcia Lopez, R. and Gardiol, D. and Garrido, D. and Garrido, L. and Gascon, D. and Gaug, M. and Gaweda, J. and Gebremedhin, L. and Geffroy, N. and Gerard, L. and Ghedina, A. and Ghigo, M. and Giannakaki, E. and Gianotti, F. and Giarrusso, S. and Giavitto, G. and Giebels, B. and Gika, V. and Giommi, P. and Girard, N. and Giro, E. and Giuliani, A. and Glanzman, T. and Glicenstein, J. -F. and Godinovic, N. and Golev, V. and Gomez Berisso, M. and Gomez-Ortega, J. and Gonzalez, M. M. and Gonzalez, A. and Gonzalez, F. and Gonzalez Munoz, A. and Gothe, K. S. and Gougerot, M. and Graciani, R. and Grandi, P. and Granena, F. and Granot, J. and Grasseau, G. and Gredig, R. and Green, A. and Greenshaw, T. and Gregoire, T. and Grimm, O. and Grube, J. and Grudzinska, M. and Gruev, V. and Gruenewald, S. and Grygorczuk, J. and Guarino, V. and Gunji, S. and Gyuk, G. and Hadasch, D. and Hagiwara, R. and Hahn, J. and Hakansson, N. and Hallgren, A. and Hamer Heras, N. and Hara, S. and Hardcastle, M. J. and Harris, J. and Hassan, T. and Hatanaka, K. and Haubold, T. and Haupt, A. and Hayakawa, T. and Hayashida, M. and Heller, R. and Henault, F. and Henri, G. and Hermann, G. and Hermel, R. and Herrero, A. and Hidaka, N. and Hinton, J. and Hoffmann, D. and Hofmann, W. and Hofverberg, P. and Holder, J. and Horns, D. and Horville, D. and Houles, J. and Hrabovsky, M. and Hrupec, D. and Huan, H. and Huber, B. and Huet, J. -M. and Hughes, G. and Humensky, T. B. and Huovelin, J. and Ibarra, A. and Illa, J. M. and Impiombato, D. and Incorvaia, S. and Inoue, S. and Inoue, Y. and Ioka, K. and Ismailova, E. and Jablonski, C. and Jacholkowska, A. and Jamrozy, M. and Janiak, M. and Jean, P. and Jeanney, C. and Jimenez, J. J. and Jogler, T. and Johnson, T. and Journet, L. and Juffroy, C. and Jung, I. and Kaaret, P. and Kabuki, S. and Kagaya, M. and Kakuwa, J. and Kalkuhl, C. and Kankanyan, R. and Karastergiou, A. and Kaercher, K. and Karczewski, M. and Karkar, S. and Kasperek, Aci. and Kastana, D. and Katagiri, H. and Kataoka, J. and Katarzynski, K. and Katz, U. and Kawanaka, N. and Kellner-Leidel, B. and Kelly, H. and Kendziorra, E. and Khelifi, B. and Kieda, D. B. and Kifune, T. and Kihm, T. and Kishimoto, T. and Kitamoto, K. and Kluzniak, W. and Knapic, C. and Knapp, J. w and Knoedlseder, J. and Koeck, F. and Kocot, J. and Kodani, K. and Koehne, J. -H. and Kohri, K. and Kokkotas, K. and Kolitzus, D. and Komin, N. and Kominis, I. and Konno, Y. and Koeppel, H. and Korohoda, P. and Kosack, K. and Koss, G. and Kossakowski, R. and Kostka, P. and Koul, R. and Kowal, G. and Koyama, S. and Koziol, J. and Kraehenbuehl, T. and Krause, J. and Krawzcynski, H. and Krennrich, F. and Krepps, A. and Kretzschmann, A. and Krobot, R. and Krueger, P. and Kubo, H. and Kudryavtsev, V. A. and Kushida, J. and Kuznetsov, A. and La Barbera, A. and La Palombara, N. and La Parola, V. and La Rosa, G. and Lacombe, K. and Lamanna, G. and Lande, J. and Languignon, D. and Lapington, J. and Laporte, P. and Lavalley, C. and Le Flour, T. and Le Padellec, A. and Lee, S. -H. and Lee, W. H. and Leigui de Oliveira, M. A. and Lelas, D. and Lenain, J. -P. and Leopold, D. J. and Lerch, T. and Lessio, L. and Lieunard, B. and Lindfors, E. and Liolios, A. and Lipniacka, A. and Lockart, H. and Lohse, T. and Lombardi, S. and Lopatin, A. and Lopez, M. and Lopez-Coto, R. and Lopez-Oramas, A. and Lorca, A. and Lorenz, E. and Lubinski, P. and Lucarelli, F. and Luedecke, H. and Ludwin, J. and Luque-Escamilla, P. L. and Lustermann, W. and Luz, O. and Lyard, E. and Maccarone, M. C. and Maccarone, T. J. and Madejski, G. M. and Madhavan, A. and Mahabir, M. and Maier, G. and Majumdar, P. and Malaguti, G. and Maltezos, S. and Manalaysay, A. and Mancilla, A. and Mandat, D. and Maneva, G. and Mangano, A. and Manigot, P. and Mannheim, K. and Manthos, I. and Maragos, N. and Marcowith, Alexandre and Mariotti, M. and Marisaldi, M. and Markoff, S. and Marszalek, A. and Martens, C. and Marti, J. and Martin, J-M. and Martin, P. and Martinez, G. and Martinez, F. and Martinez, M. and Masserot, A. and Mastichiadis, A. and Mathieu, A. and Matsumoto, H. and Mattana, F. and Mattiazzo, S. and Maurin, G. and Maxfield, S. and Maya, J. and Mazin, D. and Mc Comb, L. and McCubbin, N. and McHardy, I. and McKay, R. and Medina, C. and Melioli, C. and Melkumyan, D. and Mereghetti, S. and Mertsch, P. and Meucci, M. and Michalowski, J. and Micolon, P. and Mihailidis, A. and Mineo, T. and Minuti, M. and Mirabal, N. and Mirabel, F. and Miranda, J. M. and Mirzoyan, R. and Mizuno, T. and Moal, B. and Moderski, R. and Mognet, I. and Molinari, E. and Molinaro, M. and Montaruli, T. and Monteiro, I. and Moore, P. and Moralejo Olaizola, A. and Mordalska, M. and Morello, C. and Mori, K. and Mottez, F. and Moudden, Y. and Moulin, Emmanuel and Mrusek, I. and Mukherjee, R. and Munar-Adrover, P. and Muraishi, H. and Murase, K. and Murphy, A. and Nagataki, S. and Naito, T. and Nakajima, D. and Nakamori, T. and Nakayama, K. and Naumann, C. L. and Naumann, D. and Naumann-Godo, M. and Nayman, P. and Nedbal, D. and Neise, D. and Nellen, L. and Neustroev, V. and Neyroud, N. and Nicastro, L. and Nicolau-Kuklinski, J. and Niedzwiecki, A. and Niemiec, J. and Nieto, D. and Nikolaidis, A. and Nishijima, K. and Nolan, S. and Northrop, R. and Nosek, D. and Nowak, N. and Nozato, A. and O'Brien, P. and Ohira, Y. and Ohishi, M. and Ohm, S. and Ohoka, H. and Okuda, T. and Okumura, A. and Olive, J. -F. and Ong, R. A. and Orito, R. and Orr, M. and Osborne, J. and Ostrowski, M. and Otero, L. A. and Otte, N. and Ovcharov, E. and Oya, I. and Ozieblo, A. and Padilla, L. and Paiano, S. and Paillot, D. and Paizis, A. and Palanque, S. and Palatka, M. and Pallota, J. and Panagiotidis, K. and Panazol, J. -L. and Paneque, D. and Panter, M. and Paoletti, R. and Papayannis, Alexandros and Papyan, G. and Paredes, J. M. and Pareschi, G. and Parks, G. and Parraud, J. -M. and Parsons, D. and Arribas, M. Paz and Pech, M. and Pedaletti, G. and Pelassa, V. and Pelat, D. and Perez, M. D. C. and Persic, M. and Petrucci, P-O and Peyaud, B. and Pichel, A. and Pita, S. and Pizzolato, F. and Platos, L. and Platzer, R. and Pogosyan, L. and Pohl, M. and Pojmanski, G. and Ponz, J. D. and Potter, W. and Poutanen, J. and Prandini, E. and Prast, J. and Preece, R. and Profeti, F. and Prokoph, H. and Prouza, M. and Proyetti, M. and Puerto-Gimenez, I. and Puehlhofer, G. and Puljak, I. and Punch, M. and Pyziol, R. and Quel, E. J. and Quinn, J. and Quirrenbach, A. and Racero, E. and Rajda, P. J. and Ramon, P. and Rando, R. and Rannot, R. C. and Rataj, M. and Raue, M. and Reardon, P. and Reimann, O. and Reimer, A. and Reimer, O. and Reitberger, K. and Renaud, M. and Renner, S. and Reville, B. and Rhode, W. and Ribo, M. and Ribordy, M. and Richer, M. G. and Rico, J. and Ridky, J. and Rieger, F. and Ringegni, P. and Ripken, J. and Ristori, P. R. and Riviere, A. and Rivoire, S. and Rob, L. and Roeser, U. and Rohlfs, R. and Rojas, G. and Romano, Patrizia and Romaszkan, W. and Romero, G. E. and Rosen, S. and Lees, S. Rosier and Ross, D. and Rouaix, G. and Rousselle, J. and Rousselle, S. and Rovero, A. C. and Roy, F. and Royer, S. and Rudak, B. and Rulten, C. and Rupinski, M. and Russo, F. and Ryde, F. and Sacco, B. and Saemann, E. O. and Saggion, A. and Safiakian, V. and Saito, K. and Saito, T. and Saito, Y. and Sakaki, N. and Sakonaka, R. and Salini, A. and Sanchez, F. and Sanchez-Conde, M. and Sandoval, A. and Sandaker, H. and Sant'Ambrogio, E. and Santangelo, Andrea and Santos, E. M. and Sanuy, A. and Sapozhnikov, L. and Sarkar, S. and Sartore, N. and Sasaki, H. and Satalecka, K. and Sawada, M. and Scalzotto, V. and Scapin, V. and Scarcioffolo, M. and Schafer, J. and Schanz, T. and Schlenstedt, S. and Schlickeiser, R. and Schmidt, T. and Schmoll, J. and Schovanek, P. and Schroedter, M. and Schultz, C. and Schultze, J. and Schulz, A. and Schure, K. and Schwab, T. and Schwanke, U. and Schwarz, J. and Schwarzburg, S. and Schweizer, T. and Schwemmer, S. and Segreto, A. and Seiradakis, J. -H. and Sembroski, G. H. and Seweryn, K. and Sharma, M. and Shayduk, M. and Shellard, R. C. and Shi, J. and Shibata, T. and Shibuya, A. and Shum, E. and Sidoli, L. and Sidz, M. and Sieiro, J. and Sikora, M. and Silk, J. and Sillanpaa, A. and Singh, B. B. and Sitarek, J. and Skole, C. and Smareglia, R. and Smith, A. and Smith, D. and Smith, J. and Smith, N. and Sobczynska, D. and Sol, H. and Sottile, G. and Sowinski, M. and Spanier, F. and Spiga, D. and Spyrou, S. and Stamatescu, V. and Stamerra, A. and Starling, R. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steiner, S. and Stergioulas, N. and Sternberger, R. and Sterzel, M. and Stinzing, F. and Stodulski, M. and Straumann, U. and Strazzeri, E. and Stringhetti, L. and Suarez, A. and Suchenek, M. and Sugawara, R. and Sulanke, K. -H. and Sun, S. and Supanitsky, A. D. and Suric, T. and Sutcliffe, P. and Sykes, J. and Szanecki, M. and Szepieniec, T. and Szostek, A. and Tagliaferri, G. and Tajima, H. and Takahashi, H. and Takahashi, K. and Takalo, L. and Takami, H. and Talbot, C. and Tammi, J. and Tanaka, M. and Tanaka, S. and Tasan, J. and Tavani, M. and Tavernet, J. -P. and Tejedor, L. A. and Telezhinsky, Igor O. and Temnikov, P. and Tenzer, C. and Terada, Y. and Terrier, R. and Teshima, M. and Testa, V. and Tezier, D. and Thuermann, D. and Tibaldo, L. and Tibolla, O. and Tiengo, A. and Tluczykont, M. and Todero Peixoto, C. J. and Tokanai, F. and Tokarz, M. and Toma, K. and Torii, K. and Tornikoski, M. and Torres, D. F. and Torres, M. and Tosti, G. and Totani, T. and Toussenel, C. and Tovmassian, G. and Travnicek, P. and Trifoglio, M. and Troyano, I. and Tsinganos, K. and Ueno, H. and Umehara, K. and Upadhya, S. S. and Usher, T. and Uslenghi, M. and Valdes-Galicia, J. F. and Vallania, P. and Vallejo, G. and van Driel, W. and van Eldik, C. and Vandenbrouke, J. and Vanderwalt, J. and Vankov, H. and Vasileiadis, G. and Vassiliev, V. and Veberic, D. and Vegas, I. and Vercellone, S. and Vergani, S. and Veyssiere, C. and Vialle, J. P. and Viana, A. and Videla, M. and Vincent, P. and Vincent, S. and Vink, J. and Vlahakis, N. and Vlahos, L. and Vogler, P. and Vollhardt, A. and von Gunten, H. P. and Vorobiov, S. and Vuerli, C. and Waegebaert, V. and Wagner, R. and Wagner, R. G. and Wagner, S. and Wakely, S. P. and Walter, R. and Walther, T. and Warda, K. and Warwick, R. and Wawer, P. and Wawrzaszek, R. and Webb, N. and Wegner, P. and Weinstein, A. and Weitzel, Q. and Welsing, R. and Werner, M. and Wetteskind, H. and White, R. and Wierzcholska, A. and Wiesand, S. and Wilkinson, M. and Williams, D. A. and Willingale, R. and Winiarski, K. and Wischnewski, R. and Wisniewski, L. and Wood, M. and Woernlein, A. and Xiong, Q. and Yadav, K. K. and Yamamoto, H. and Yamamoto, T. and Yamazaki, R. and Yanagita, S. and Yebras, J. M. and Yelos, D. and Yoshida, A. and Yoshida, T. and Yoshikoshi, T. and Zabalza, V. and Zacharias, M. and Zajczyk, A. and Zanin, R. and Zdziarski, A. and Zech, Alraune and Zhao, A. and Zhou, X. and Zietara, K. and Ziolkowski, J. and Ziolkowski, P. and Zitelli, V. and Zurbach, C. and Zychowski, P.}, title = {Introducing the CTA concept}, series = {Astroparticle physics}, volume = {43}, journal = {Astroparticle physics}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, organization = {CTA Consortium}, issn = {0927-6505}, doi = {10.1016/j.astropartphys.2013.01.007}, pages = {3 -- 18}, year = {2013}, abstract = {The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project.}, language = {en} } @article{WernoWilhelmiKuropkaetal.2018, author = {Werno, Martin Witold and Wilhelmi, Ilka and Kuropka, Benno and Ebert, Franziska and Freund, Christian and Sch{\"u}rmann, Annette}, title = {The GTPase ARFRP1 affects lipid droplet protein composition and triglyceride release from intracellular storage of intestinal Caco-2 cells}, series = {Biochemical and biophysical research communications}, volume = {506}, journal = {Biochemical and biophysical research communications}, number = {1}, publisher = {Elsevier}, address = {San Diego}, issn = {0006-291X}, doi = {10.1016/j.bbrc.2018.10.092}, pages = {259 -- 265}, year = {2018}, abstract = {Intestinal release of dietary triglycerides via chylomicrons is the major contributor to elevated postprandial triglyceride levels. Dietary lipids can be transiently stored in cytosolic lipid droplets (LDs) located in intestinal enterocytes for later release. ADP ribosylation factor-related protein 1 (ARFRP1) participates in processes of LD growth in adipocytes and in lipidation of lipoproteins in liver and intestine. This study aims to explore the impact of ARFRP1 on LD organization and its interplay with chylomicron-mediated triglyceride release in intestinal-like Caco-2 cells. Suppression of Arfrp1 reduced release of intracellularly derived triglycerides (0.69-fold) and increased the abundance of transitional endoplasmic reticulum ATPase TERA/VCP, fatty acid synthase-associated factor 2 (FAF2) and perilipin 2 (Plin2) at the LD surface. Furthermore, TERA/VCP and FAF2 co-occurred more frequently with ATGL at LDs, suggesting a reduced adipocyte triglyceride lipase (ATGL)-mediated lipolysis. Accordingly, inhibition of lipolysis reduced lipid release from intracellular storage pools by the same magnitude as Arfrp1 depletion. Thus, the lack of Arfrp1 increases the abundance of lipolysis-modulating enzymes TERA/VCP, FAF2 and Plin2 at LDs, which might decrease lipolysis and reduce availability of fatty acids for triglyceride synthesis and their release via chylomicrons. (C) 2018 The Authors. Published by Elsevier Inc.}, language = {en} } @article{DiekmannAndresBeckeretal.2019, author = {Diekmann, Martin and Andres, Christian and Becker, Thomas and Bennie, Jonathan and Blueml, Volker and Bullock, James M. and Culmsee, Heike and Fanigliulo, Miriam and Hahn, Annett and Heinken, Thilo and Leuschner, Christoph and Luka, Stefanie and Meissner, Justus and M{\"u}ller, Josef and Newton, Adrian and Peppler-Lisbach, Cord and Rosenthal, Gert and van den Berg, Leon J. L. and Vergeer, Philippine and Wesche, Karsten}, title = {Patterns of long-term vegetation change vary between different types of semi-natural grasslands in Western and Central Europe}, series = {Journal of vegetation science}, volume = {30}, journal = {Journal of vegetation science}, number = {2}, publisher = {Wiley}, address = {Hoboken}, issn = {1100-9233}, doi = {10.1111/jvs.12727}, pages = {187 -- 202}, year = {2019}, abstract = {Questions Has plant species richness in semi-natural grasslands changed over recent decades? Do the temporal trends of habitat specialists differ from those of habitat generalists? Has there been a homogenization of the grassland vegetation? Location Different regions in Germany and the UK. Methods We conducted a formal meta-analysis of re-survey vegetation studies of semi-natural grasslands. In total, 23 data sets were compiled, spanning up to 75 years between the surveys, including 13 data sets from wet grasslands, six from dry grasslands and four from other grassland types. Edaphic conditions were assessed using mean Ellenberg indicator values for soil moisture, nitrogen and pH. Changes in species richness and environmental variables were evaluated using response ratios. Results In most wet grasslands, total species richness declined over time, while habitat specialists almost completely vanished. The number of species losses increased with increasing time between the surveys and were associated with a strong decrease in soil moisture and higher soil nutrient contents. Wet grasslands in nature reserves showed no such changes or even opposite trends. In dry grasslands and other grassland types, total species richness did not consistently change, but the number or proportions of habitat specialists declined. There were also considerable changes in species composition, especially in wet grasslands that often have been converted into intensively managed, highly productive meadows or pastures. We did not find a general homogenization of the vegetation in any of the grassland types. Conclusions The results document the widespread deterioration of semi-natural grasslands, especially of those types that can easily be transformed to high production grasslands. The main causes for the loss of grassland specialists are changed management in combination with increased fertilization and nitrogen deposition. Dry grasslands are most resistant to change, but also show a long-term trend towards an increase in more mesotrophic species.}, language = {en} } @misc{ManzoniCapekPoradaetal.2018, author = {Manzoni, Stefano and Capek, Petr and Porada, Philipp and Thurner, Martin and Winterdahl, Mattias and Beer, Christian and Bruchert, Volker and Frouz, Jan and Herrmann, Anke M. and Lindahl, Bjorn D. and Lyon, Steve W. and Šantrůčkov{\´a}, Hana and Vico, Giulia and Way, Danielle}, title = {Reviews and syntheses}, series = {Biogeosciences}, volume = {15}, journal = {Biogeosciences}, number = {19}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1726-4170}, doi = {10.5194/bg-15-5929-2018}, pages = {5929 -- 5949}, year = {2018}, abstract = {The cycling of carbon (C) between the Earth surface and the atmosphere is controlled by biological and abiotic processes that regulate C storage in biogeochemical compartments and release to the atmosphere. This partitioning is quantified using various forms of C-use efficiency (CUE) - the ratio of C remaining in a system to C entering that system. Biological CUE is the fraction of C taken up allocated to biosynthesis. In soils and sediments, C storage depends also on abiotic processes, so the term C-storage efficiency (CSE) can be used. Here we first review and reconcile CUE and CSE definitions proposed for autotrophic and heterotrophic organisms and communities, food webs, whole ecosystems and watersheds, and soils and sediments using a common mathematical framework. Second, we identify general CUE patterns; for example, the actual CUE increases with improving growth conditions, and apparent CUE decreases with increasing turnover. We then synthesize > 5000CUE estimates showing that CUE decreases with increasing biological and ecological organization - from uni-cellular to multicellular organisms and from individuals to ecosystems. We conclude that CUE is an emergent property of coupled biological-abiotic systems, and it should be regarded as a flexible and scale-dependent index of the capacity of a given system to effectively retain C.}, language = {en} } @article{GerberEhrbarBrandetal.2018, author = {Gerber, Markus and Ehrbar, Janine and Brand, Ralf and Antoniewicz, Franziska and Brand, Serge and Colledge, Flora and Donath, Lars and Egger, Stephan T. and Hatzinger, Martin and Holsboer-Trachsler, Edith and Imboden, Christian and Schweinfurth, Nina and Vetter, Stefan and Ludyga, Sebastian}, title = {Implicit attitudes towards exercise and physical activity behaviour among in-patients with psychiatric disorders}, series = {Mental Health and Physical Activity}, volume = {15}, journal = {Mental Health and Physical Activity}, publisher = {Elsevier}, address = {Oxford}, issn = {1755-2966}, doi = {10.1016/j.mhpa.2018.08.001}, pages = {71 -- 77}, year = {2018}, abstract = {The current body of evidence suggests that in healthy participants, implicit attitudes towards physical activity explain variance in exercise behaviour beyond explicit cognitive processes. However, such relationships have not been examined in psychiatric patients, although this may contribute to a better understanding of the motivational and volitional resources needed to self-regulate their exercise behaviour. Therefore, the present cross-sectional study aimed to assess implicit attitudes towards exercise among psychiatric in-patients, and to correlate these implicit attitudes with their physical activity levels. Patients (N = 101) showing a psychiatric disorder, but no severe cognitive impairment, were directly recruited from psychiatric clinics. Their physical activity levels were assessed using both accelerometers and self-reports. Additionally, patients reported psychiatric symptoms and performed a single-target implicit association test (ST-IAT) with exercise employed as the target category. Of all patients, 39\% showed a preference for exercise, whereas 13\% showed an aversion towards exercise. The implicit attitudes of the remaining participants were equally strong for both concepts. Based on correlational analysis (correcting for age, sex, psychiatric symptoms severity, and ST-IAT sequence), no association was found between ST-IAT score, or self-reported and objectively assessed physical activity. Consequently, the link between exercise behaviour and implicit attitudes towards physical activity found in healthy participants could not be observed in psychiatric patients.}, language = {en} } @article{WunderKutzschbachHosseetal.2018, author = {Wunder, Bernd and Kutzschbach, Martin and Hosse, Luisa and Wilke, Franziska Daniela Helena and Schertl, Hans-Peter and Chopin, Christian}, title = {Synthetic B-[4]-bearing dumortierite and natural B-[4]-free magnesiodumortierite from the Dora-Maira Massif}, series = {European journal of mineralogy}, volume = {30}, journal = {European journal of mineralogy}, number = {3}, publisher = {Schweizerbart}, address = {Stuttgart}, issn = {0935-1221}, doi = {10.1127/ejm/2018/0030-2742}, pages = {471 -- 483}, year = {2018}, abstract = {Dumortierite was synthesized in piston-cylinder experiments at 2.5-4.0 GPa, 650-700 degrees C in the Al2O3 -B2O3-SiO2-H2O (ABSH) system. Electron-microprobe (EMP) analyses reveal significant boron-excess (up to 0.26 B-[4] per formula unit, pfu) and silicon-deficiency relative to the ideal anhydrous dumortierite stoichiometry Al7BSi3O18 . The EMP data in conjunction with results from single-crystal Raman spectroscopy and powder X-ray diffraction provide evidence that silicon at the tetrahedral site is replaced by excess boron via the substitution Si-[4] <--> B-[4] + H. The Raman spectrum of synthetic dumortierite in the frequency region 2000 4000 cm(-1) comprises eight bands, of which six are located at frequencies below 3400 cm(-1). This points to strong hydrogen bonding, most likely O2-H center dot center dot center dot O7 and O7-H center dot center dot center dot O2, arising from a high number of octahedral vacancies at the All site and substitution of trivalent Al3+ and B3+ for Si4+ at Si1 and Si2 sites, causing decreasing acceptor-donor distances and lower incident valence at the acceptor oxygen. Contrary to the synthetic high-pressure ABSH-dumortierite, magnesiodumortierite from the Dora-Maira Massif, which is assumed to have formed at similar conditions (2.5-3.0 GPa, 700 degrees C), does not show any B-excess. Tourmaline shows an analogous behaviour in that magnesium-rich (e.g., dravitic) tourmaline formed at high pressure shows no or only minor amounts of tetrahedral boron, whereas natural aluminum-rich tourmaline and synthetic olenitic tourmaline formed at high pressures can incorporate significant amounts of tetrahedral boron. Two mechanisms might account for this discrepancy: (i) Structural avoidance of Mg-[6]-(OR3+)-R-[4] configurations in magnesiodumortierite due to charge deficieny at the oxygens O2 and O7 and strong local distortion of M1 due to decreased O2-O7 bond length, and/or (ii) decreasing fluid mobility of boron in Al-rich systems at high pressures.}, language = {en} } @misc{BierbachSchulteHerrmannetal.2011, author = {Bierbach, David and Schulte, Matthias and Herrmann, Nina and Tobler, Michael and Stadler, Stefan and Jung, Christian T. and Kunkel, Benjamin and Riesch, R{\"u}diger and Klaus, Sebastian and Ziege, Madlen and Indy, Jeane Rimber and Arias-Rodriguez, Lenin and Plath, Martin}, title = {Predator-induced changes of female mating preferences}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {984}, issn = {1866-8372}, doi = {10.25932/publishup-43109}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431099}, pages = {12}, year = {2011}, abstract = {Background In many species males face a higher predation risk than females because males display elaborate traits that evolved under sexual selection, which may attract not only females but also predators. Females are, therefore, predicted to avoid such conspicuous males under predation risk. The present study was designed to investigate predator-induced changes of female mating preferences in Atlantic mollies (Poecilia mexicana). Males of this species show a pronounced polymorphism in body size and coloration, and females prefer large, colorful males in the absence of predators. Results In dichotomous choice tests predator-na{\"i}ve (lab-reared) females altered their initial preference for larger males in the presence of the cichlid Cichlasoma salvini, a natural predator of P. mexicana, and preferred small males instead. This effect was considerably weaker when females were confronted visually with the non-piscivorous cichlid Vieja bifasciata or the introduced non-piscivorous Nile tilapia (Oreochromis niloticus). In contrast, predator experienced (wild-caught) females did not respond to the same extent to the presence of a predator, most likely due to a learned ability to evaluate their predators' motivation to prey. Conclusions Our study highlights that (a) predatory fish can have a profound influence on the expression of mating preferences of their prey (thus potentially affecting the strength of sexual selection), and females may alter their mate choice behavior strategically to reduce their own exposure to predators. (b) Prey species can evolve visual predator recognition mechanisms and alter their mate choice only when a natural predator is present. (c) Finally, experiential effects can play an important role, and prey species may learn to evaluate the motivational state of their predators.}, language = {en} } @article{MartinHaberlandRietbrock2005, author = {Martin, Sebastian and Haberland, Christian and Rietbrock, Andreas}, title = {Forearc decoupling of guided waves in the Chile-Peru subduction zone}, year = {2005}, abstract = {The structure and alterations of subducted oceanic lithosphere ( e. g., thickness and seismic velocity of oceanic crust) can be obtained by analyzing guided seismic waves generated by earthquakes within the slab (Wadati- Benioff zone). In northern Chile prominent secondary phases from intermediate-depth seismicity, observed in the forearc region can be interpreted as guided waves. For the observation of guided waves it is usually required to have stations close to the wave guide, a fact which is not directly given for forearc stations in subduction zone environments. With the help of finite difference simulations we model the decoupling mechanism of guided waves at the contact between the descending oceanic plate and the upper plate crust where the wave guide is opened due to the equalization of seismic velocities. Provided that suited stations are available, this mechanism allows for the use of intermediate depth seismicity to study the shallow subduction zone structure ( <= 100 km depth)}, language = {en} } @article{KubasCassanBeaulieuetal.2005, author = {Kubas, Daniel and Cassan, A. and Beaulieu, Jean-Philippe and Coutures, C. and Dominik, M. and Albrow, Michael D. and Brillant, Stephane and Caldwell, John A. R. and Dominis, Dijana and Donatowicz, J. and Fendt, Christian and Fouque, P. and Jorgensen, Uffe Grae and Greenhill, John and Hill, K. and Heinm{\"u}ller, Janine and Horne, Keith and Kane, Stephen R. and Marquette, Jean-Baptiste and Martin, Ralph and Menzies, J. W. and Pollard, K. R. and Sahu, K. C. and Vinter, C. and Wambsganss, Joachim and Watson, R. and Williams, A. and Thurl, C.}, title = {Full characterization of binary-lens event OGLE-2002-BLG-069 from PLANET observations}, issn = {0004-6361}, year = {2005}, abstract = {We analyze the photometric data obtained by PLANET and OGLE on the caustic-crossing binary-lens microlensing event OGLE-2002-BLG-069. Thanks to the excellent photometric and spectroscopic coverage of the event, we are able to constrain the lens model up to the known ambiguity between close and wide binary lenses. The detection of annual parallax in combination with measurements of extended-source effects allows us to determine the mass, distance and velocity of the lens components for the competing models. While the model involving a close binary lens leads to a Bulge- Disc lens scenario with a lens mass of M = (0.51 ± 0.15) M-\&ODOT; and distance of D-L = (2.9 ± 0.4) kpc, the wide binary lens solution requires a rather implausible binary black-hole lens ( M \&GSIM; 126 M-\&ODOT;). Furthermore we compare current state-of-the-art numerical and empirical models for the surface brightness profile of the source, a G5III Bulge giant. We find that a linear limb-darkening model for the atmosphere of the source star is consistent with the data whereas a PHOENIX atmosphere model assuming LTE and with no free parameter does not match our observations}, language = {en} } @article{CassanBeaulieuBrillantetal.2004, author = {Cassan, A. and Beaulieu, Jean-Philippe and Brillant, Stephane and Coutures, C. and Dominik, M. and Donatowicz, J. and Jorgensen, Uffe Grae and Kubas, Daniel and Albrow, Michael D. and Caldwell, John A. R. and Fouque, P. and Greenhill, John and Hill, K. and Horne, Keith and Kane, Stephen R. and Martin, Ralph and Menzies, J. W. and Pollard, K. R. and Sahu, K. C. and Vinter, C. and Wambsganss, Joachim and Watson, R. and Williams, A. and Fendt, Christian and Hauschildt, P. and Heinmueller, Janine and Marquette, Jean-Baptiste and Thurl, C.}, title = {Probing the atmosphere of the bulge G5III star OGLE-2002-BUL-069 by analysis of microlensed H alpha line}, year = {2004}, abstract = {We discuss high-resolution, time-resolved spectra of the caustic exit of the binary microlensing event OGLE 2002-BLG-069 obtained with UVES on the VLT. The source star is a G5III giant in the Galactic Bulge. During such events, the source star is highly magnified, and a strong differential magnification around the caustic resolves its surface. Using an appropriate model stellar atmosphere generated by the PHOENIX v2.6 code we obtain a model light curve for the caustic exit and compare it with a dense set of photometric observations obtained by the PLANET microlensing follow up network. We further compare predicted variations in the Halpha equivalent width with those measured from our spectra. While the model and observations agree in the gross features, there are discrepancies suggesting shortcomings in the model, particularly for the Halpha line core, where we have detected amplified emission from the stellar chromosphere after the source star's trailing limb exited the caustic. This achievement became possible by the provision of the very efficient OGLE-III Early Warning System, a network of small telescopes capable of nearly-continuous round-the-clock photometric monitoring, on-line data reduction, daily near-real-time modelling in order to predict caustic crossing parameters, and a fast and efficient response of a 8 m class telescope to a "Target-of-Opportunity" observation request}, language = {en} } @article{ZiemannSchmidtMirwald2004, author = {Ziemann, Martin Andreas and Schmidt, Christian and Mirwald, Peter W.}, title = {Raman spectroscopic study of the liquid-liquid transition in water}, issn = {0024-4937}, year = {2004}, language = {en} } @article{vonLoeffelholzLieskeNeuschaeferRubeetal.2017, author = {von Loeffelholz, Christian and Lieske, Stefanie and Neuschaefer-Rube, Frank and Willmes, Diana M. and Raschzok, Nathanael and Sauer, Igor M. and K{\"o}nig, J{\"o}rg and Fromm, Martin F. and Horn, Paul and Chatzigeorgiou, Antonios and Pathe-Neuschaefer-Rube, Andrea and Jordan, Jens and Pfeiffer, Andreas F. H. and Mingrone, Geltrude and Bornstein, Stefan R. and Stroehle, Peter and Harms, Christoph and Wunderlich, F. Thomas and Helfand, Stephen L. and Bernier, Michel and de Cabo, Rafael and Shulman, Gerald I. and Chavakis, Triantafyllos and P{\"u}schel, Gerhard Paul and Birkenfeld, Andreas L.}, title = {The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism}, series = {Hepatology}, volume = {66}, journal = {Hepatology}, number = {2}, publisher = {Wiley}, address = {Hoboken}, issn = {0270-9139}, doi = {10.1002/hep.29089}, pages = {616 -- 630}, year = {2017}, abstract = {Reduced expression of the Indy ("I am Not Dead, Yet") gene in lower organisms promotes longevity in a manner akin to caloric restriction. Deletion of the mammalian homolog of Indy (mIndy, Slc13a5) encoding for a plasma membrane-associated citrate transporter expressed highly in the liver, protects mice from high-fat diet-induced and aging-induced obesity and hepatic fat accumulation through a mechanism resembling caloric restriction. We studied a possible role of mIndy in human hepatic fat metabolism. In obese, insulin-resistant patients with nonalcoholic fatty liver disease, hepatic mIndy expression was increased and mIndy expression was also independently associated with hepatic steatosis. In nonhuman primates, a 2-year high-fat, high-sucrose diet increased hepatic mIndy expression. Liver microarray analysis showed that high mIndy expression was associated with pathways involved in hepatic lipid metabolism and immunological processes. Interleukin-6 (IL-6) was identified as a regulator of mIndy by binding to its cognate receptor. Studies in human primary hepatocytes confirmed that IL-6 markedly induced mIndy transcription through the IL-6 receptor and activation of the transcription factor signal transducer and activator of transcription 3, and a putative start site of the human mIndy promoter was determined. Activation of the IL-6-signal transducer and activator of transcription 3 pathway stimulated mIndy expression, enhanced cytoplasmic citrate influx, and augmented hepatic lipogenesis in vivo. In contrast, deletion of mIndy completely prevented the stimulating effect of IL-6 on citrate uptake and reduced hepatic lipogenesis. These data show that mIndy is increased in liver of obese humans and nonhuman primates with NALFD. Moreover, our data identify mIndy as a target gene of IL-6 and determine novel functions of IL-6 through mINDY. Conclusion: Targeting human mINDY may have therapeutic potential in obese patients with nonalcoholic fatty liver disease. German Clinical Trials Register: DRKS00005450.}, language = {en} } @article{KabothBahrBahrStepaneketal.2021, author = {Kaboth-Bahr, Stefanie and Bahr, Andr{\´e} and Stepanek, Christian and Catunda, Maria Carolina Amorim and Karas, Cyrus and Ziegler, Martin and Garc{\´i}a-Gallardo, {\´A}ngela and Grunert, Patrick}, title = {Mediterranean heat injection to the North Atlantic delayed the intensification of Northern Hemisphere glaciations}, series = {Communications Earth \& Environment}, journal = {Communications Earth \& Environment}, publisher = {Springer Nature}, address = {London}, issn = {2662-4435}, doi = {10.1038/s43247-021-00232-5}, pages = {1 -- 9}, year = {2021}, abstract = {The intensification of Northern Hemisphere glaciations at the end of the Pliocene epoch marks one of the most substantial climatic shifts of the Cenozoic. Despite global cooling, sea surface temperatures in the high latitude North Atlantic Ocean rose between 2.9-2.7 million years ago. Here we present sedimentary geochemical proxy data from the Gulf of Cadiz to reconstruct the variability of Mediterranean Outflow Water, an important heat source to the North Atlantic. We find evidence for enhanced production of Mediterranean Outflow from the mid-Pliocene to the late Pliocene which we infer could have driven a sub-surface heat channel into the high-latitude North Atlantic. We then use Earth System Models to constrain the impact of enhanced Mediterranean Outflow production on the northward heat transport in the North Atlantic. In accord with the proxy data, the numerical model results support the formation of a sub-surface channel that pumped heat from the subtropics into the high latitude North Atlantic. We further suggest that this mechanism could have delayed ice sheet growth at the end of the Pliocene.}, language = {en} } @article{EichlerSalzwedelReibisetal.2017, author = {Eichler, Sarah and Salzwedel, Annett and Reibis, Rona and Nothroff, J{\"o}rg and Harnath, Axel and Schikora, Martin and Butter, Christian and Wegscheider, Karl and V{\"o}ller, Heinz}, title = {Multicomponent cardiac rehabilitation in patients after transcatheter aortic valve implantation}, series = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, volume = {24}, journal = {European journal of preventive cardiology : the official ESC journal for primary \& secondary cardiovascular prevention, rehabilitation and sports cardiology}, number = {3}, publisher = {Sage Publ.}, address = {London}, issn = {2047-4873}, doi = {10.1177/2047487316679527}, pages = {257 -- 264}, year = {2017}, abstract = {Background: In the last decade, transcatheter aortic valve implantation has become a promising treatment modality for patients with aortic stenosis and a high surgical risk. Little is known about influencing factors of function and quality of life during multicomponent cardiac rehabilitation. Methods: From October 2013 to July 2015, patients with elective transcatheter aortic valve implantation and a subsequent inpatient cardiac rehabilitation were enrolled in the prospective cohort multicentre study. Frailty-Index (including cognition, nutrition, autonomy and mobility), Short Form-12 (SF-12), six-minute walk distance (6MWD) and maximum work load in bicycle ergometry were performed at admission and discharge of cardiac rehabilitation. The relation between patient characteristics and improvements in 6MWD, maximum work load or SF-12 scales were studied univariately and multivariately using regression models. Results: One hundred and thirty-six patients (80.6 +/- 5.0 years, 47.8\% male) were enrolled. 6MWD and maximum work load increased by 56.3 +/- 65.3 m (p < 0.001) and 8.0 +/- 14.9 watts (p < 0.001), respectively. An improvement in SF-12 (physical 2.5 +/- 8.7, p = 0.001, mental 3.4 +/- 10.2, p = 0.003) could be observed. In multivariate analysis, age and higher education were significantly associated with a reduced 6MWD, whereas cognition and obesity showed a positive predictive value. Higher cognition, nutrition and autonomy positively influenced the physical scale of SF-12. Additionally, the baseline values of SF-12 had an inverse impact on the change during cardiac rehabilitation. Conclusions: Cardiac rehabilitation can improve functional capacity as well as quality of life and reduce frailty in patients after transcatheter aortic valve implantation. An individually tailored therapy with special consideration of cognition and nutrition is needed to maintain autonomy and empower octogenarians in coping with challenges of everyday life.}, language = {en} } @article{TritschMartensSunetal.2017, author = {Tritsch, Christian and Martens, Jochen and Sun, Yue-Hua and Heim, Wieland and Strutzenberger, Patrick and P{\"a}ckert, Martin}, title = {Improved sampling at the subspecies level solves a taxonomic dilemma}, series = {Molecular phylogenetics and evolution}, volume = {107}, journal = {Molecular phylogenetics and evolution}, publisher = {Elsevier}, address = {San Diego}, issn = {1055-7903}, doi = {10.1016/j.ympev.2016.12.014}, pages = {538 -- 550}, year = {2017}, abstract = {A recent full species-level phylogeny of tits, titmice and chickadees (Paridae) has placed the Chinese endemic black-bibbed tit (Poecile hypermelaenus) as the sister to the Palearctic willow tit (P. montanus). Because this sister-group relationship is in striking disagreement with the traditional affiliation of P. hypermelaenus close to the marsh tit (P. palustris) we tested this phylogenetic hypothesis in a multi locus analysis with an extended taxon sampling including sixteen subspecies of willow tits and marsh tits. As a taxonomic reference we included type specimens in our analysis. The molecular genetic study was complemented with an analysis of biometric data obtained from museum specimens. Our phylogenetic reconstructions, including a comparison of all GenBank data available for our target species, clearly show that the genetic lineage previously identified as P. hypermelaenus actually refers to P. weigoldicus because sequences were identical to that of a syntype of this taxon. The close relationship of P. weigoldicus and P. montanus - despite large genetic distances between the two taxa - is in accordance with current taxonomy and systematics. In disagreement with the previous phylogenetic hypothesis but in accordance with most taxonomic authorities, all our P. hypermelaenus specimens fell in the sister Glade of all western and eastern Palearctic P. palustris. Though shared haplotypes among the Chinese populations of the two latter species might indicate mitochondrial introgression in this part of the breeding range, further research is needed here due to the limitations of our own sampling.}, language = {en} } @article{PaalvastVerhammeStrakaetal.2018, author = {Paalvast, M. and Verhamme, A. and Straka, L. A. and Brinchmann, J. and Herenz, Edmund Christian and Carton, D. and Gunawardhana, M. L. P. and Boogaard, L. A. and Cantalupo, S. and Contini, T. and Epinat, Benoit and Inami, H. and Marino, R. A. and Maseda, M. V. and Michel-Dansac, L. and Muzahid, S. and Nanayakkara, T. and Pezzulli, Gabriele and Richard, J. and Schaye, Joop and Segers, M. C. and Urrutia, Tanya and Wendt, Martin and Wisotzki, Lutz}, title = {Properties and redshift evolution of star-forming galaxies with high [0 III]/[O II] ratios with MUSE at 0.28 < z < 0.85}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {618}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {0004-6361}, doi = {10.1051/0004-6361/201832866}, pages = {15}, year = {2018}, abstract = {We present a study of the [O III]/[O II] ratios of star-forming galaxies drawn from Multi-Unit Spectroscopic Explorer (MUSE) data spanning a redshift range 0.28 < z < 0.85. Recently discovered Lyman continuum (LyC) emitters have extremely high oxygen line ratios: [O III]lambda 5007/[O II]lambda lambda 3726, 3729 > 4. Here we aim to understand the properties and the occurrences of galaxies with such high line ratios. Combining data from several MUSE Guaranteed Time Observing (GTO) programmes, we select a population of star-forming galaxies with bright emission lines, from which we draw 406 galaxies for our analysis based on their position in the z-dependent star formation rate (SFR) stellar mass (M*) plane. Out of this sample 15 are identified as extreme oxygen emitters based on their [O III]/[O II] ratios (3.7\%) and 104 galaxies have [O III]/[O II] > 1 (26\%). Our analysis shows no significant correlation between M*, SFR, and the distance from the SFR M, relation with [O III]/[O II]. We find a decrease in the fraction of galaxies with [O III]/[O II] > 1 with increasing M*, however, this is most likely a result of the relationship between [O III]/[O II] and metallicity, rather than between [O III]/[O II] and M. We draw a comparison sample of local analogues with < z > 0.03 from the Sloan Digital Sky Survey, and find similar incidence rates for this sample. In order to investigate the evolution in the fraction of high [O III]/[O II] emitters with redshift, we bin the sample into three redshift subsamples of equal number, but find no evidence for a dependence on redshift. Furthermore, we compare the observed line ratios with those predicted by nebular models with no LyC escape and find that most of the extreme oxygen emitters can be reproduced by low metallicity models. The remaining galaxies are likely LyC emitter candidates.}, language = {en} } @article{JohnsonChenStrakaetal.2018, author = {Johnson, Sean D. and Chen, Hsiao-Wen and Straka, Lorrie and Schaye, Joop and Cantalupo, Sebastiano and Wendt, Martin and Muzahid, Sowgat and Bouch{\´e}, Nicolas and Herenz, Edmund Christian and Kollatschny, Wolfram and Mulchaey, John S. and Marino, Raffaella A. and Maseda, Michael and Wisotzki, Lutz}, title = {Galaxy and quasar fueling caught in the act from the intragroup to the interstellar medium}, series = {The astrophysical journal : Part 2, Letters}, volume = {869}, journal = {The astrophysical journal : Part 2, Letters}, number = {1}, publisher = {IOP Publishing Ltd. (Bristol)}, address = {Bristol}, issn = {2041-8205}, doi = {10.3847/2041-8213/aaf1cf}, pages = {7}, year = {2018}, abstract = {We report the discovery of six spatially extended (10-100 kpc) line-emitting nebulae in the z approximate to 0.57 galaxy group hosting PKS 0405-123, one of the most luminous quasars at z < 1. The discovery is enabled by the Multi Unit Spectroscopic Explorer and provides tantalizing evidence connecting large-scale gas streams with nuclear activity on scales of <10 proper kpc (pkpc). One of the nebulae exhibits a narrow, filamentary morphology extending over 50 pkpc toward the quasar with narrow internal velocity dispersion (50 km s(-1)) and is not associated with any detected galaxies, consistent with a cool intragroup medium filament. Two of the nebulae are 10 pkpc north and south of the quasar with tidal-arm-like morphologies. These two nebulae, along with a continuum-emitting arm extending 60 pkpc from the quasar, are signatures of interactions that are expected to redistribute angular momentum in the host interstellar medium (ISM) to facilitate star formation and quasar fueling in the nucleus. The three remaining nebulae are among the largest and most luminous [O III] emitting "blobs" known (1400-2400 pkpc(2)) and correspond both kinematically and morphologically to interacting galaxy pairs in the quasar host group, consistent with arising from stripped ISM rather than large-scale quasar outflows. The presence of these large- and small-scale nebulae in the vicinity of a luminous quasar bears significantly on the effect of large-scale environment on galaxy and black hole fueling, providing a natural explanation for the previously known correlation between quasar luminosity and cool circumgalactic medium.}, language = {en} } @article{KellerKunzeBommeretal.2018, author = {Keller, Sebastian and Kunze, Cindy and Bommer, Martin and Paetz, Christian and Menezes, Riya C. and Svatos, Ales and Dobbek, Holger and Schubert, Torsten}, title = {Selective Utilization of Benzimidazolyl-Norcobamides as Cofactors by the Tetrachloroethene Reductive Dehalogenase of Sulfurospirillum multivorans}, series = {Journal of bacteriology}, volume = {200}, journal = {Journal of bacteriology}, number = {8}, publisher = {American Society for Microbiology}, address = {Washington}, issn = {0021-9193}, doi = {10.1128/JB.00584-17}, pages = {14}, year = {2018}, abstract = {The organohalide-respiring bacterium Sulfurospirillum multivorans produces a unique cobamide, namely, norpseudo-B-12, which serves as cofactor of the tetrachloroethene (PCE) reductive dehalogenase (PceA). As previously reported, a replacement of the adeninyl moiety, the lower base of the cofactor, by exogenously applied 5,6-dimethylbenzimidazole led to inactive PceA. To explore the general effect of benzimidazoles on the PCE metabolism, the susceptibility of the organism for guided biosynthesis of various singly substituted benzimidazolyl-norcobamides was investigated, and their use as cofactor by PceA was analyzed. Exogenously applied 5-methylbenzimidazole (5-MeBza), 5-hydroxybenzimidazole (5-OHBza), and 5-methoxybenzimidazole (5-OMeBza) were found to be efficiently incorporated as lower bases into norcobamides (NCbas). Structural analysis of the NCbas by nuclear magnetic resonance spectroscopy uncovered a regioselectivity in the utilization of these precursors for NCba biosynthesis. When 5-MeBza was added, a mixture of 5-MeBza-norcobamide and 6-MeBza-norcobamide was formed, and the PceA enzyme activity was affected. In the presence of 5-OHBza, almost exclusively 6-OHBza-norcobamide was produced, while in the presence of 5-OMeBza, predominantly 5-OMeBza-norcobamide was detected. Both NCbas were incorporated into PceA, and no negative effect on the PceA activity was observed. In crystal structures of PceA, both NCbas were bound in the base-off mode with the 6-OHBza and 5-OMeBza lower bases accommodated by the same solvent-exposed hydrophilic pocket that harbors the adenine as the lower base of authentic norpseudo-B-12. In this study, a selective production of different norcobamide isomers containing singly substituted benzimidazoles as lower bases is shown, and unique structural insights into their utilization as co-factors by a cobamide-containing enzyme are provided. IMPORTANCE Guided biosynthesis of norcobamides containing singly substituted benzimidazoles as lower bases by the organohalide-respiring epsilonproteobacterium Sulfurospirillum multivorans is reported. An unprecedented specificity in the formation of norcobamide isomers containing hydroxylated or methoxylated benzimidazoles was observed that implicated a strict regioselectivity of the norcobamide biosynthesis in the organism. In contrast to 5,6-dimethylbenzimidazolyl-norcobamide, the incorporation of singly substituted benzimidazolyl-norcobamides as a cofactor into the tetrachloroethene reductive dehalogenase was not impaired. The enzyme was found to be functional with different isomers and not limited to the use of adeninyl-norcobamide. Structural analysis of the enzyme equipped with either adeninyl-or benzimidazolyl-norcobamide cofactors visualized for the first time structurally different cobamides bound in base-off conformation to the cofactor-binding site of a cobamide-containing enzyme.}, language = {en} } @article{HerppichMartinToetzkeetal.2019, author = {Herppich, Werner B. and Martin, Craig E. and T{\"o}tzke, Christian and Manke, Ingo and Kardjilov, Nikolay}, title = {External water transport is more important than vascular transport in the extreme atmospheric epiphyte Tillandsia usneoides (Spanish moss)}, series = {Plant, cell \& environment : cell physiology, whole-plant physiology, community physiology}, volume = {42}, journal = {Plant, cell \& environment : cell physiology, whole-plant physiology, community physiology}, number = {5}, publisher = {Wiley}, address = {Hoboken}, issn = {0140-7791}, doi = {10.1111/pce.13496}, pages = {1645 -- 1656}, year = {2019}, abstract = {Most epiphytic bromeliads, especially those in the genus Tillandsia, lack functional roots and rely on the absorption of water and nutrients by large, multicellular trichomes on the epidermal surfaces of leaves and stems. Another important function of these structures is the spread of water over the epidermal surface by capillary action between trichome "wings" and epidermal surface. Although critical for the ultimate absorption by these plants, understanding of this function of trichomes is primarily based on light microscope observations. To better understand this phenomenon, the distribution of water was followed by its attenuation of cold neutrons following application of H2O to the cut end of Tillandsia usneoides shoots. Experiments confirmed the spread of added water on the external surfaces of this "atmospheric" epiphyte. In a morphologically and physiologically similar plant lacking epidermal trichomes, water added to the cut end of a shoot clearly moved via its internal xylem and not on its epidermis. Thus, in T. usneoides, water moves primarily by capillarity among the overlapping trichomes forming a dense indumentum on shoot surfaces, while internal vascular water movement is less likely. T. usneoides, occupying xeric microhabitats, benefits from reduction of water losses by low-shoot xylem hydraulic conductivities.}, language = {en} } @article{MiedemaThielemannKuehnCalafelletal.2019, author = {Miedema, Piter S. and Thielemann-K{\"u}hn, Nele and Calafell, Irati Alonso and Sch{\"u}ßler-Langeheine, Christian and Beye, Martin}, title = {Strain analysis from M-edge resonant inelastic X-ray scattering of nickel oxide films}, series = {Physical chemistry, chemical physics : a journal of European Chemical Societies}, volume = {21}, journal = {Physical chemistry, chemical physics : a journal of European Chemical Societies}, number = {38}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1463-9076}, doi = {10.1039/c9cp03593a}, pages = {21596 -- 21602}, year = {2019}, abstract = {Electronic structure modifications due to strain are an effective method for tailoring nano-scale functional materials. Demonstrated on nickel oxide (NiO) thin films, Resonant Inelastic X-ray Scattering (RIXS) at the transition-metal M-2,M-3-edge is shown to be a powerful tool for measuring the electronic structure modification due to strain in the near-surface region. Analyses from the M-2,M-3-edge RIXS in comparison with dedicated crystal field multiplet calculations show distortions in 40 nm NiO grown on a magnesium oxide (MgO) substrate (NiO/MgO) similar to those caused by surface relaxation of bulk NiO. The films of 20 and 10 nm NiO/MgO show slightly larger differences from bulk NiO. Quantitatively, the NiO/MgO samples all are distorted from perfect octahedral (O-h) symmetry with a tetragonal parameter Ds of about -0.1 eV, very close to the Ds distortion from octahedral (O-h) symmetry parameter of -0.11 eV obtained for the surface-near region from a bulk NiO crystal. Comparing the spectra of a 20 nm film of NiO grown on a 20 nm magnetite (Fe3O4) film on a MgO substrate (NiO/Fe3O4/MgO) with the calculated multiplet analyses, the distortion parameter Ds appears to be closer to zero, showing that the surface-near region of this templated film is less distorted from O-h symmetry than the surface-near region in bulk NiO. Finally, the potential of M-2,M-3-edge RIXS for other investigations of strain on electronic structure is discussed.}, language = {en} } @article{SchallGossnerHeinrichsetal.2017, author = {Schall, Peter and Gossner, Martin M. and Heinrichs, Steffi and Fischer, Markus and Boch, Steffen and Prati, Daniel and Jung, Kirsten and Baumgartner, Vanessa and Blaser, Stefan and B{\"o}hm, Stefan and Buscot, Francois and Daniel, Rolf and Goldmann, Kezia and Kaiser, Kristin and Kahl, Tiemo and Lange, Markus and M{\"u}ller, J{\"o}rg Hans and Overmann, J{\"o}rg and Renner, Swen C. and Schulze, Ernst-Detlef and Sikorski, Johannes and Tschapka, Marco and T{\"u}rke, Manfred and Weisser, Wolfgang W. and Wemheuer, Bernd and Wubet, Tesfaye and Ammer, Christian}, title = {The impact of even-aged and uneven-aged forest management on regional biodiversity of multiple taxa in European beech forests}, series = {Journal of applied ecology : an official journal of the British Ecological Society}, volume = {55}, journal = {Journal of applied ecology : an official journal of the British Ecological Society}, number = {1}, publisher = {Wiley}, address = {Hoboken}, issn = {0021-8901}, doi = {10.1111/1365-2664.12950}, pages = {267 -- 278}, year = {2017}, abstract = {1. For managed temperate forests, conservationists and policymakers favour fine-grained uneven-aged (UEA) management over more traditional coarse-grained even-aged (EA) management, based on the assumption that within-stand habitat heterogeneity enhances biodiversity. There is, however, little empirical evidence to support this assumption. We investigated for the first time how differently grained forest management systems affect the biodiversity of multiple above- and below-ground taxa across spatial scales. 2. We sampled 15 taxa of animals, plants, fungi and bacteria within the largest contiguous beech forest landscape of Germany and classified them into functional groups. Selected forest stands have been managed for more than a century at different spatial grains. The EA (coarse-grained management) and UEA (fine-grained) forests are comparable in spatial arrangement, climate and soil conditions. These were compared to forests of a nearby national park that have been unmanaged for at least 20years. We used diversity accumulation curves to compare -diversity for Hill numbers D-0 (species richness), D-1 (Shannon diversity) and D-2 (Simpson diversity) between the management systems. Beta diversity was quantified as multiple-site dissimilarity. 3. Gamma diversity was higher in EA than in UEA forests for at least one of the three Hill numbers for six taxa (up to 77\%), while eight showed no difference. Only bacteria showed the opposite pattern. Higher -diversity in EA forests was also found for forest specialists and saproxylic beetles. 4. Between-stand -diversity was higher in EA than in UEA forests for one-third (all species) and half (forest specialists) of all taxa, driven by environmental heterogeneity between age-classes, while -diversity showed no directional response across taxa or for forest specialists. 5. Synthesis and applications. Comparing EA and uneven-aged forest management in Central European beech forests, our results show that a mosaic of different age-classes is more important for regional biodiversity than high within-stand heterogeneity. We suggest reconsidering the current trend of replacing even-aged management in temperate forests. Instead, the variability of stages and stand structures should be increased to promote landscape-scale biodiversity.}, language = {en} } @article{HeinrichsAmmerMundetal.2019, author = {Heinrichs, Steffi and Ammer, Christian and Mund, Martina and Boch, Steffen and Budde, Sabine and Fischer, Markus and Mueller, Joerg and Schoening, Ingo and Schulze, Ernst-Detlef and Schmidt, Wolfgang and Weckesser, Martin and Schall, Peter}, title = {Landscape-Scale Mixtures of Tree Species are More Effective than Stand-Scale Mixtures for Biodiversity of Vascular Plants, Bryophytes and Lichens}, series = {Forests}, volume = {10}, journal = {Forests}, number = {1}, publisher = {MDPI}, address = {Basel}, issn = {1999-4907}, doi = {10.3390/f10010073}, pages = {34}, year = {2019}, abstract = {Tree species diversity can positively affect the multifunctionality of forests. This is why conifer monocultures of Scots pine and Norway spruce, widely promoted in Central Europe since the 18th and 19th century, are currently converted into mixed stands with naturally dominant European beech. Biodiversity is expected to benefit from these mixtures compared to pure conifer stands due to increased abiotic and biotic resource heterogeneity. Evidence for this assumption is, however, largely lacking. Here, we investigated the diversity of vascular plants, bryophytes and lichens at the plot (alpha diversity) and at the landscape (gamma diversity) level in pure and mixed stands of European beech and conifer species (Scots pine, Norway spruce, Douglas fir) in four regions in Germany. We aimed to identify compositions of pure and mixed stands in a hypothetical forest landscape that can optimize gamma diversity of vascular plants, bryophytes and lichens within regions. Results show that gamma diversity of the investigated groups is highest when a landscape comprises different pure stands rather than tree species mixtures at the stand scale. Species mainly associated with conifers rely on light regimes that are only provided in pure conifer forests, whereas mixtures of beech and conifers are more similar to beech stands. Combining pure beech and pure conifer stands at the landscape scale can increase landscape level biodiversity and conserve species assemblages of both stand types, while landscapes solely composed of stand scale tree species mixtures could lead to a biodiversity reduction of a combination of investigated groups of 7 up to 20\%.}, language = {en} } @article{PruefertVillatoroLealZuehlkeetal.2022, author = {Pr{\"u}fert, Christian and Villatoro Leal, Jos{\´e} Andr{\´e}s and Z{\"u}hlke, Martin and Beitz, Toralf and L{\"o}hmannsr{\"o}ben, Hans-Gerd}, title = {Liquid phase IR-MALDI and differential mobility analysis of nano- and sub-micron particles}, series = {Physical chemistry, chemical physics : a journal of European Chemical Societies}, volume = {24}, journal = {Physical chemistry, chemical physics : a journal of European Chemical Societies}, number = {4}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1463-9076}, doi = {10.1039/d1cp04196g}, pages = {2275 -- 2286}, year = {2022}, abstract = {Infrared matrix-assisted desorption and ionization (IR-MALDI) enables the transfer of sub-micron particles (sMP) directly from suspensions into the gas phase and their characterization with differential mobility (DM) analysis. A nanosecond laser pulse at 2940 nm induces a phase explosion of the aqueous phase, dispersing the sample into nano- and microdroplets. The particles are ejected from the aqueous phase and become charged. Using IR-MALDI on sMP of up to 500 nm in diameter made it possible to surpass the 100 nm size barrier often encountered when using nano-electrospray for ionizing supramolecular structures. Thus, the charge distribution produced by IR-MALDI could be characterized systematically in the 50-500 nm size range. Well-resolved signals for up to octuply charged particles were obtained in both polarities for different particle sizes, materials, and surface modifications spanning over four orders of magnitude in concentrations. The physicochemical characterization of the IR-MALDI process was done via a detailed analysis of the charge distribution of the emerging particles, qualitatively as well as quantitatively. The Wiedensohler charge distribution, which describes the evolution of particle charging events in the gas phase, and a Poisson-derived charge distribution, which describes the evolution of charging events in the liquid phase, were compared with one another with respect to how well they describe the experimental data. Although deviations were found in both models, the IR-MALDI charging process seems to resemble a Poisson-like charge distribution mechanism, rather than a bipolar gas phase charging one.}, language = {en} } @article{MartinBehrendt2014, author = {Martin, Christian and Behrendt, Daniel}, title = {Perspektiven f{\"u}r eine nachhaltige Kriminalpr{\"a}vention im Land Brandenburg}, series = {Nachhaltige Pr{\"a}vention von Kriminalit{\"a}t, Gewalt und Rechtsextremismus : Beitr{\"a}ge aus Wissenschaft und Praxis}, journal = {Nachhaltige Pr{\"a}vention von Kriminalit{\"a}t, Gewalt und Rechtsextremismus : Beitr{\"a}ge aus Wissenschaft und Praxis}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-71477}, pages = {439 -- 445}, year = {2014}, abstract = {Perspektiven f{\"u}r eine nachhaltige Kriminalpr{\"a}vention im Land Brandenburg}, language = {de} } @article{GrunwaldtHaebelSpitzetal.2002, author = {Grunwaldt, Gisela and Haebel, Sophie and Spitz, Christian and Steup, Martin and Menzel, Ralf}, title = {Multiple binding sites of fluorescein isothiocyanate moieties on myoglobin : photophysical heterogeneity as revealed by ground- and excited-state spectroscopy}, issn = {1011-1344}, year = {2002}, language = {en} } @article{WisotzkiBaconBlaizotetal.2016, author = {Wisotzki, Lutz and Bacon, Roland and Blaizot, J. and Brinchmann, Jarle and Herenz, Edmund Christian and Schaye, Joop and Bouche, Nicolas and Cantalupo, Sebastiano and Contini, Thierry and Carollo, C. M. and Caruana, Joseph and Courbot, J. -B. and Emsellem, E. and Kamann, S. and Kerutt, Josephine Victoria and Leclercq, F. and Lilly, S. J. and Patricio, V. and Sandin, C. and Steinmetz, Matthias and Straka, Lorrie A. and Urrutia, Tanya and Verhamme, A. and Weilbacher, Peter Michael and Wendt, Martin}, title = {Extended Lyman alpha haloes around individual high-redshift galaxies revealed by MUSE}, series = {Science}, volume = {587}, journal = {Science}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {1432-0746}, doi = {10.1051/0004-6361/201527384}, pages = {27}, year = {2016}, abstract = {We report the detection of extended Ly alpha emission around individual star-forming galaxies at redshifts z = 3-6 in an ultradeep exposure of the Hubble Deep Field South obtained with MUSE on the ESO-VLT. The data reach a limiting surface brightness (1 sigma) of similar to 1 x 10(-19) erg s(-1) cm(-2) arcsec(-2) in azimuthally averaged radial profiles, an order of magnitude improvement over previous narrowband imaging. Our sample consists of 26 spectroscopically confirmed Ly alpha-emitting, but mostly continuum-faint (m(AB) greater than or similar to 27) galaxies. In most objects the Ly alpha emission is considerably more extended than the UV continuum light. While five of the faintest galaxies in the sample show no significantly detected Ly alpha haloes, the derived upper limits suggest that this is due to insufficient S/N. Ly alpha haloes therefore appear to be ubiquitous even for low-mass (similar to 10(8)-10(9) M-circle dot) star-forming galaxies at z > 3. We decompose the Ly alpha emission of each object into a compact component tracing the UV continuum and an extended halo component, and infer sizes and luminosities of the haloes. The extended Ly alpha emission approximately follows an exponential surface brightness distribution with a scale length of a few kpc. While these haloes are thus quite modest in terms of their absolute sizes, they are larger by a factor of 5-15 than the corresponding rest-frame UV continuum sources as seen by HST. They are also much more extended, by a factor similar to 5, than Ly alpha haloes around low-redshift star-forming galaxies. Between similar to 40\% and greater than or similar to 90\% of the observed Ly alpha flux comes from the extended halo component, with no obvious correlation of this fraction with either the absolute or the relative size of the Ly alpha halo. Our observations provide direct insights into the spatial distribution of at least partly neutral gas residing in the circumgalactic medium of low to intermediate mass galaxies at z > 3.}, language = {en} } @misc{KabothBahrBahrStepaneketal.2021, author = {Kaboth-Bahr, Stefanie and Bahr, Andr{\´e} and Stepanek, Christian and Catunda, Maria Carolina Amorim and Karas, Cyrus and Ziegler, Martin and Garc{\´i}a-Gallardo, {\´A}ngela and Grunert, Patrick}, title = {Mediterranean heat injection to the North Atlantic delayed the intensification of Northern Hemisphere glaciations}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {1237}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1866-8372}, doi = {10.25932/publishup-54876}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-548762}, pages = {1 -- 9}, year = {2021}, abstract = {The intensification of Northern Hemisphere glaciations at the end of the Pliocene epoch marks one of the most substantial climatic shifts of the Cenozoic. Despite global cooling, sea surface temperatures in the high latitude North Atlantic Ocean rose between 2.9-2.7 million years ago. Here we present sedimentary geochemical proxy data from the Gulf of Cadiz to reconstruct the variability of Mediterranean Outflow Water, an important heat source to the North Atlantic. We find evidence for enhanced production of Mediterranean Outflow from the mid-Pliocene to the late Pliocene which we infer could have driven a sub-surface heat channel into the high-latitude North Atlantic. We then use Earth System Models to constrain the impact of enhanced Mediterranean Outflow production on the northward heat transport in the North Atlantic. In accord with the proxy data, the numerical model results support the formation of a sub-surface channel that pumped heat from the subtropics into the high latitude North Atlantic. We further suggest that this mechanism could have delayed ice sheet growth at the end of the Pliocene.}, language = {en} } @article{DenouxMartinCreuzburgKoussoroplisetal.2017, author = {Denoux, Clemence and Martin-Creuzburg, Dominik and Koussoroplis, Apostolos-Manuel and Perriere, Fanny and Desvillettes, Christian and Bourdier, Gilles and Bec, Alexandre}, title = {Phospholipid-bound eicosapentaenoic acid (EPA) supports higher fecundity than free EPA in Daphnia magna}, series = {Journal of plankton research}, volume = {39}, journal = {Journal of plankton research}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0142-7873}, doi = {10.1093/plankt/fbx037}, pages = {843 -- 848}, year = {2017}, abstract = {Nutrition bioassays in which polyunsaturated fatty acids (PUFA)-deficient diets were supplemented with free long-chain PUFA (>= C20) consistently revealed positive effects on somatic growth and fecundity of Daphnia. However, free PUFA are hardly available in natural diets. In general, PUFA are bound to other lipids, especially to phospholipids and triglycerides. Here, we evaluate the potential of free and phospholipid-bound dietary eicosapentaenoic acid (EPA) to support somatic growth and fecundity of Daphnia magna. In a growth experiment, supplementation of a C20 PUFA-deficient diet with free or phospholipid-bound EPA improved somatic growth rates of D. magna equally. However, the increase in fecundity was significantly more pronounced when phospholipid-bound EPA was provided. Free and phospholipid-bound EPA were provided in the same concentrations in our experiment, suggesting that the allocation to reproduction-related processes is affected differently by phospholipid-bound PUFA and free PUFA. Our finding stresses the need to consider the distribution of dietary PUFA in different lipid classes to gain a better understanding of how PUFA influence life history traits of Daphnids in the field.}, language = {en} } @article{SchloerHolzloehnerListeketal.2018, author = {Schl{\"o}r, Anja and Holzl{\"o}hner, Pamela and Listek, Martin and Grieß, Cindy and Butze, Monique and Micheel, Burkhard and Hentschel, Christian and Sowa, Mandy and Roggenbuck, Dirk and Schierack, Peter and F{\"u}ner, Jonas and Schliebs, Erik and Goihl, Alexander and Reinhold, Dirk and Hanack, Katja}, title = {Generation and validation of murine monoclonal and camelid recombinant single domain antibodies specific for human pancreatic glycoprotein 2}, series = {New biotechnology}, volume = {45}, journal = {New biotechnology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1871-6784}, doi = {10.1016/j.nbt.2018.03.006}, pages = {60 -- 68}, year = {2018}, abstract = {Pancreatic secretory zymogen-granule membrane glycoprotein 2 (GP2) has been identified as a major autoantigenic target in Crohn's disease patients. It was reported recently that a long (GP2a) and a short (GP2b) isoform of GP2 exist and that in the outcome of inflammatory bowel diseases (IBD) GP2-specific autoantibodies probably appear as new serological markers for diagnosis and therapeutic monitoring. To investigate this further and in order to establish diagnostic tools for the discrimination of both GP2 isoforms, a set of different murine monoclonal and camelid recombinant single domain antibodies (camelid VHH) was generated and validated in various enzyme-linked immunosorbent assay (ELISA) formats, immunofluorescence on transgenic cell lines and immunohistochemistry on monkey pancreas tissue sections. Out of six binders identified, one was validated as highly specific for GP2a. This murine monoclonal antibody (mAb) was used as capture antibody in construction of a sandwich ELISA for the detection of GP2a. Camelid VHHs or a second murine mAb served as detection antibodies in this system. All antibodies were also able to stain GP2a or GP2b on transgenic cell lines as well as on pancreatic tissue in immunohistochemistry. The KD values measured for the camelid VHHs were between 7 nM and 23pM. This set of specific binders will enable the development of suitable diagnostic tools for GP2-related studies in IBD.}, language = {en} }