@article{AceroAloisioAmansetal.2017,
  author    = {Acero, F. and Aloisio, R. and Amans, J. and Amato, Elena and Antonelli, L. A. and Aramo, C. and Armstrong, T. and Arqueros, F. and Asano, Katsuaki and Ashley, M. and Backes, M. and Balazs, C. and Balzer, A. and Bamba, Aya and Barkov, Maxim and Barrio, J. A. and Benbow, Wystan and Bernloehr, K. and Beshley, V. and Bigongiari, C. and Biland, A. and Bilinsky, A. and Bissaldi, Elisabetta and Biteau, J. and Blanch, O. and Blasi, P. and Blazek, J. and Boisson, C. and Bonanno, G. and Bonardi, A. and Bonavolonta, C. and Bonnoli, G. and Braiding, C. and Brau-Nogue, S. and Bregeon, J. and Brown, A. M. and Bugaev, V. and Bulgarelli, A. and Bulik, T. and Burton, Michael and Burtovoi, A. and Busetto, G. and Bottcher, M. and Cameron, R. and Capalbi, M. and Caproni, Anderson and Caraveo, P. and Carosi, R. and Cascone, E. and Cerruti, M. and Chaty, Sylvain and Chen, A. and Chen, X. and Chernyakova, M. and Chikawa, M. and Chudoba, J. and Cohen-Tanugi, J. and Colafrancesco, S. and Conforti, V. and Contreras, J. L. and Costa, A. and Cotter, G. and Covino, Stefano and Covone, G. and Cumani, P. and Cusumano, G. and Daniel, M. and Dazzi, F. and De Angelis, A. and De Cesare, G. and De Franco, A. and De Frondat, F. and Dal Pino, E. M. de Gouveia and De Lisio, C. and Lopez, R. de los Reyes and De Lotto, B. and de Naurois, M. and De Palma, F. and Del Santo, M. and Delgado, C. and della Volpe, D. and Di Girolamo, T. and Di Giulio, C. and Di Pierro, F. and Di Venere, L. and Doro, M. and Dournaux, J. and Dumas, D. and Dwarkadas, Vikram V. and Diaz, C. and Ebr, J. and Egberts, Kathrin and Einecke, S. and Elsaesser, D. and Eschbach, S. and Falceta-Goncalves, D. and Fasola, G. and Fedorova, E. and Fernandez-Barral, A. and Ferrand, Gilles and Fesquet, M. and Fiandrini, E. and Fiasson, A. and Filipovic, Miroslav D. and Fioretti, V. and Font, L. and Fontaine, Gilles and Franco, F. J. and Freixas Coromina, L. and Fujita, Yutaka and Fukui, Y. and Funk, S. and Forster, A. and Gadola, A. and Lopez, R. Garcia and Garczarczyk, M. and Giglietto, N. and Giordano, F. and Giuliani, A. and Glicenstein, J. and Gnatyk, R. and Goldoni, P. and Grabarczyk, T. and Graciani, R. and Graham, J. and Grandi, P. and Granot, Jonathan and Green, A. J. and Griffiths, S. and Gunji, S. and Hakobyan, H. and Hara, S. and Hassan, T. and Hayashida, M. and Heller, M. and Helo, J. C. and Hinton, J. and Hnatyk, B. and Huet, J. and Huetten, M. and Humensky, T. B. and Hussein, M. and Horandel, J. and Ikeno, Y. and Inada, T. and Inome, Y. and Inoue, S. and Inoue, T. and Inoue, Y. and Ioka, K. and Iori, Maurizio and Jacquemier, J. and Janecek, P. and Jankowsky, D. and Jung, I. and Kaaret, P. and Katagiri, H. and Kimeswenger, S. and Kimura, Shigeo S. and Knodlseder, J. and Koch, B. and Kocot, J. and Kohri, K. and Komin, N. and Konno, Y. and Kosack, K. and Koyama, S. and Kraus, Michaela and Kubo, Hidetoshi and Mezek, G. Kukec and Kushida, J. and La Palombara, N. and Lalik, K. and Lamanna, G. and Landt, H. and Lapington, J. and Laporte, P. and Lee, S. and Lees, J. and Lefaucheur, J. and Lenain, J. -P. and Leto, Giuseppe and Lindfors, E. and Lohse, T. and Lombardi, S. and Longo, F. and Lopez, M. and Lucarelli, F. and Luque-Escamilla, Pedro Luis and Lopez-Coto, R. and Maccarone, M. C. and Maier, G. and Malaguti, G. and Mandat, D. and Maneva, G. and Mangano, S. and Marcowith, Alexandre and Marti, J. and Martinez, M. and Martinez, G. and Masuda, S. and Maurin, G. and Maxted, N. and Melioli, Claudio and Mineo, T. and Mirabal, N. and Mizuno, T. and Moderski, R. and Mohammed, M. and Montaruli, T. and Moralejo, A. and Mori, K. and Morlino, G. and Morselli, A. and Moulin, Emmanuel and Mukherjee, R. and Mundell, C. and Muraishi, H. and Murase, Kohta and Nagataki, Shigehiro and Nagayoshi, T. and Naito, T. and Nakajima, D. and Nakamori, T. and Nemmen, R. and Niemiec, Jacek and Nieto, D. and Nievas-Rosillo, M. and Nikolajuk, M. and Nishijima, K. and Noda, K. and Nogues, L. and Nosek, D. and Novosyadlyj, B. and Nozaki, S. and Ohira, Yutaka and Ohishi, M. and Ohm, S. and Okumura, A. and Ong, R. A. and Orito, R. and Orlati, A. and Ostrowski, M. and Oya, I. and Padovani, Marco and Palacio, J. and Palatka, M. and Paredes, Josep M. and Pavy, S. and Persic, M. and Petrucci, P. and Petruk, Oleh and Pisarski, A. and Pohl, Martin and Porcelli, A. and Prandini, E. and Prast, J. and Principe, G. and Prouza, M. and Pueschel, Elisa and Puelhofer, G. and Quirrenbach, A. and Rameez, M. and Reimer, O. and Renaud, M. and Ribo, M. and Rico, J. and Rizi, V. and Rodriguez, J. and Fernandez, G. Rodriguez and Rodriguez Vazquez, J. J. and Romano, Patrizia and Romeo, G. and Rosado, J. and Rousselle, J. and Rowell, G. and Rudak, B. and Sadeh, I. and Safi-Harb, S. and Saito, T. and Sakaki, N. and Sanchez, D. and Sangiorgi, P. and Sano, H. and Santander, M. and Sarkar, S. and Sawada, M. and Schioppa, E. J. and Schoorlemmer, H. and Schovanek, P. and Schussler, F. and Sergijenko, O. and Servillat, M. and Shalchi, A. and Shellard, R. C. and Siejkowski, H. and Sillanpaa, A. and Simone, D. and Sliusar, V. and Sol, H. and Stanic, S. and Starling, R. and Stawarz, L. and Stefanik, S. and Stephan, M. and Stolarczyk, T. and Szanecki, M. and Szepieniec, T. and Tagliaferri, G. and Tajima, H. and Takahashi, M. and Takeda, J. and Tanaka, M. and Tanaka, S. and Tejedor, L. A. and Telezhinsky, Igor O. and Temnikov, P. and Terada, Y. and Tescaro, D. and Teshima, M. and Testa, V. and Thoudam, S. and Tokanai, F. and Torres, D. F. and Torresi, E. and Tosti, G. and Townsley, C. and Travnicek, P. and Trichard, C. and Trifoglio, M. and Tsujimoto, S. and Vagelli, V. and Vallania, P. and Valore, L. and van Driel, W. and van Eldik, C. and Vandenbroucke, Justin and Vassiliev, V. and Vecchi, M. and Vercellone, Stefano and Vergani, S. and Vigorito, C. and Vorobiov, S. and Vrastil, M. and Vazquez Acosta, M. L. and Wagner, S. J. and Wagner, R. and Wakely, S. P. and Walter, R. and Ward, J. E. and Watson, J. J. and Weinstein, A. and White, M. and White, R. and Wierzcholska, A. and Wilcox, P. and Williams, D. A. and Wischnewski, R. and Wojcik, P. and Yamamoto, T. and Yamamoto, H. and Yamazaki, Ryo and Yanagita, S. and Yang, L. and Yoshida, T. and Yoshida, M. and Yoshiike, S. and Yoshikoshi, T. and Zacharias, M. and Zampieri, L. and Zanin, R. and Zavrtanik, M. and Zavrtanik, D. and Zdziarski, A. and Zech, Alraune and Zechlin, Hannes and Zhdanov, V. and Ziegler, A. and Zorn, J.},
  title     = {Prospects for Cherenkov Telescope Array Observations of the Young Supernova Remnant RX J1713.7-3946},
  series = {The astrophysical journal : an international review of spectroscopy and astronomical physics},
  volume    = {840},
  journal   = {The astrophysical journal : an international review of spectroscopy and astronomical physics},
  number    = {2},
  publisher = {IOP Publ. Ltd.},
  address   = {Bristol},
  issn      = {0004-637X},
  doi       = {10.3847/1538-4357/aa6d67},
  pages     = {14},
  year      = {2017},
  abstract  = {We perform simulations for future Cherenkov Telescope Array (CTA) observations of RX J1713.7-3946, a young supernova remnant (SNR) and one of the brightest sources ever discovered in very high energy (VHE) gamma rays. Special attention is paid to exploring possible spatial (anti) correlations of gamma rays with emission at other wavelengths, in particular X-rays and CO/H I emission. We present a series of simulated images of RX J1713.7-3946 for CTA based on a set of observationally motivated models for the gamma-ray emission. In these models, VHE gamma rays produced by high-energy electrons are assumed to trace the nonthermal X-ray emission observed by XMM-Newton, whereas those originating from relativistic protons delineate the local gas distributions. The local atomic and molecular gas distributions are deduced by the NANTEN team from CO and H I observations. Our primary goal is to show how one can distinguish the emission mechanism(s) of the gamma rays (i.e., hadronic versus leptonic, or a mixture of the two) through information provided by their spatial distribution, spectra, and time variation. This work is the first attempt to quantitatively evaluate the capabilities of CTA to achieve various proposed scientific goals by observing this important cosmic particle accelerator.},
  language  = {en}
}
@article{AbdallaAharonianAitBenkhalietal.2018,
  author    = {Abdalla, Hassan E. and Aharonian, Felix A. and Ait Benkhali, Faical and Ang{\"u}ner, Ekrem Oǧuzhan and Arakawa, M. and Arcaro, C. and Armand, C. and Arrieta, M. and Backes, Michael and Barnard, M. and Becherini, Yvonne and Tjus, J. Becker and Berge, D. and Bernhard, S. and Bernl{\"o}hr, Konrad and Blackwell, R. and B{\"o}ttcher, Markus and Boisson, C. and Bolmont, Julien and Bonnefoy, S. and Bordas, Pol and Bregeon, J. and Brun, F. and Brun, P. and Bryan, M. and B{\"u}chele, M. and Bulik, Tomasz and Bylund, Tomas and Capasso, Massimo and Caroff, S. and Carosi, A. and Casanova, Sabrina and Cerruti, Matteo and Chakraborty, Nachiketa and Chandra, S. and Chaves, R. C. G. and Chen, A. and Colafrancesco, Sergio and Condon, B. and Davids, Isak and Deil, Christoph and Devin, J. and deWilt, P. and Dirson, L. and Djannati-Atai, A. and Dmytriiev, A. and Donath, Axel and Doroshenko, Victor and Dyks, J. and Egberts, Kathrin and Emery, G. and Ernenwein, J. -P. and Eschbach, Stefan and Fegan, S. and Fiasson, Armand and Fontaine, G. and Funk, Sebastian and F{\"u}ßling, Matthias and Gabici, S. and Gallant, Y. A. and Gate, F. and Giavitto, Gianluca and Eisenacher Glawion, Dorit and Glicenstein, Jean-Fran{\c{c}}ois and Gottschall, D. and Grondin, Marie-H{\´e}l{\`e}ne and Hahn, J. and Haupt, M. and Heinzelmann, G. and Henri, Gilles and Hermann, G. and Hinton, James Anthony and Hofmann, Werner and Hoischen, Clemens and Holch, Tim Lukas and Holler, M. and Horns, D. and Huber, D. and Iwasaki, H. and Jacholkowska, A. and Jamrozy, M. and Jankowsky, David and Jankowsky, Felix and Jouvin, L. and Jung-Richardt, I. and Kastendieck, M. A. and Katarzyński, Krzysztof and Katsuragawa, M. and Katz, U. and Kerszberg, D. and Khangulyan, D. and Khelifi, B. and King, J. and Klepser, S. and Kluzniak, W. and Komin, Nu. and Kosack, K. and Krakau, S. and Kraus, M. and Kruger, P. P. and Lamanna, G. and Lau, J. and Lefaucheur, J. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Leser, Eva and Lohse, T. and Lorentz, M. and Lopez-Coto, R. and Lypova, I. and Malyshev, D. and Marandon, V. and Marcowith, Alexandre and Mariaud, C. and Marti-Devesa, G. and Marx, R. and Maurin, G. and Meintjes, P. J. and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Moulin, Emmanuel and Murach, T. and Nakashima, S. and de Naurois, M. and Ndiyavala, H. and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, H. and Ohm, S. and Ostrowski, M. and Oya, I. and Padovani, M. and Panter, M. and Parsons, R. D. and Perennes, C. and Petrucci, P. -O. and Peyaud, B. and Piel, Q. and Pita, S. and Poireau, V. and Noel, A. Priyana and Prokhorov, D. A. and Prokoph, H. and Puehlhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Rauth, R. and Reimer, A. and Reimer, O. and Renaud, M. and Rieger, F. and Rinchiuso, L. and Romoli, C. and Rowell, G. and Rudak, B. and Ruiz-Velasco, E. and Sahakian, V. and Saito, S. and Sanchez, D. A. and Santangelo, Andrea and Sasaki, M. and Schlickeiser, R. and Schussler, F. and Schulz, A. and Schwanke, U. and Schwemmer, S. and Seglar-Arroyo, M. and Senniappan, M. and Seyffert, A. S. and Shafi, N. and Shilon, I. and Shiningayamwe, K. and Simoni, R. and Sinha, A. and Sol, H. and Spanier, F. and Specovius, A. and Spir-Jacob, M. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steppa, Constantin Beverly and Takahashi, T. and Tavernet, J. -P. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tibaldo, L. and Tiziani, D. and Tluczykont, M. and Trichard, C. and Tsirou, M. and Tsuji, N. and Tuffs, R. and Uchiyama, Y. and van der Walt, D. J. and van Eldik, C. and van Rensburg, C. and van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Viana, A. and Vincent, P. and Vink, J. and Voisin, F. and Voelk, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and Wagner, R. M. and White, R. and Wierzcholska, A. and Yang, R. and Zaborov, D. and Zacharias, M. and Zanin, R. and Zdziarski, A. and Zech, Alraune and Zefi, F. and Ziegler, A. and Zorn, J. and Zywucka, N. and Cirelli, M. and Panci, P. and Sala, F. and Silk, J. and Taoso, M.},
  title     = {Searches for gamma-ray lines and 'pure WIMP' spectra from Dark Matter annihilations in dwarf galaxies with H.E.S.S.},
  series = {Journal of cosmology and astroparticle physics},
  journal   = {Journal of cosmology and astroparticle physics},
  number    = {11},
  publisher = {IOP Publishing Ltd. (Bristol)},
  address   = {Bristol},
  organization    = {HESS Collaboration},
  issn      = {1475-7516},
  doi       = {10.1088/1475-7516/2018/11/037},
  pages     = {22},
  year      = {2018},
  abstract  = {Dwarf spheroidal galaxies are among the most promising targets for detecting signals of Dark Matter (DM) annihilations. The H.E.S.S. experiment has observed five of these systems for a total of about 130 hours. The data are re-analyzed here, and, in the absence of any detected signals, are interpreted in terms of limits on the DM annihilation cross section. Two scenarios are considered: i) DM annihilation into mono-energetic gamma-rays and ii) DM in the form of pure WIMP multiplets that, annihilating into all electroweak bosons, produce a distinctive gamma-ray spectral shape with a high-energy peak at the DM mass and a lower-energy continuum. For case i), upper limits at 95\% confidence level of about <sigma upsilon > less than or similar to 3 x 10(-25) cm(3) s(-1) are obtained in the mass range of 400 GeV to 1TeV. For case ii), the full spectral shape of the models is used and several excluded regions are identified, but the thermal masses of the candidates are not robustly ruled out.},
  language  = {en}
}
@article{AbdallaAbramowskiAharonianetal.2016,
  author    = {Abdalla, Hassan E. and Abramowski, Attila and Aharonian, Felix A. and Benkhali, Fai{\c{c}}al Ait and Akhperjanian, A. G. and Ang{\"u}ner, Ekrem Oǧuzhan and Arrieta, M. and Aubert, Pierre and Backes, Michael and Balzer, Arnim and Barnard, Michelle and Becherini, Yvonne and Tjus, Julia Becker and Berge, David and Bernhard, Sabrina and Bernl{\"o}hr, K. and Birsin, E. and Blackwell, R. and Bottcher, Markus and Boisson, Catherine and Bolmont, J. and Bordas, Pol and Bregeon, Johan and Brun, Francois and Brun, Pierre and Bryan, Mark and Bulik, Tomasz and Capasso, M. and Carr, John and Casanova, Sabrina and Chakraborty, N. and Chalme-Calvet, R. and Chaves, Ryan C. G. and Chen, Andrew and Chevalier, J. and Chretien, M. and Colafrancesco, Sergio and Cologna, Gabriele and Condon, B. and Conrad, Jan and Couturier, C. and Cui, Y. and Davids, I. D. and Degrange, B. and Deil, Christoph and deWilt, P. and Djannati-Atai, Arache and Domainko, Wilfried and Donath, Axel and Dubus, Guillaume and Dutson, Kate and Dyks, J. and Dyrda, M. and Edwards, T. and Egberts, Kathrin and Eger, P. and Ernenwein, J. -P. and Eschbach, S. and Farnier, C. and Fegan, Stuart and Fernandes, M. V. and Fiasson, A. and Fontaine, G. and Foerster, A. and Funk, S. and F{\"u}ßling, Matthias and Gabici, Stefano and Gajdus, M. and Gallant, Y. A. and Garrigoux, T. and Giavitto, Gianluca and Giebels, B. and Glicenstein, J. F. and Gottschall, Daniel and Goyal, A. and Grondin, M. -H. and Grudzinska, M. and Hadasch, Daniela and Hahn, J. and Hawkes, J. and Heinzelmann, G. and Henri, Gilles and Hermann, G. and Hervet, Olivier and Hillert, A. and Hinton, James Anthony and Hofmann, Werner and Hoischen, Clemens and Holler, M. and Horns, D. and Ivascenko, Alex and Jacholkowska, A. and Jamrozy, Marek and Janiak, M. and Jankowsky, D. and Jankowsky, Felix and Jingo, M. and Jogler, Tobias and Jouvin, Lea and Jung-Richardt, Ira and Kastendieck, M. A. and Katarzynski, Krzysztof and Katz, Uli and Kerszberg, D. and Khelifi, B. and Kieffer, M. and King, J. and Klepser, S. and Klochkov, Dmitry and Kluzniak, W. and Kolitzus, D. and Komin, Nu. and Kosack, K. and Krakau, S. and Kraus, Michael and Krayzel, F. and Kruger, P. P. and Laffon, H. and Lamanna, G. and Lau, Jeanie and Lees, J. -P. and Lefaucheur, J. and Lefranc, V. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Leser, Eva and Lohse, Thomas and Lorentz, M. and Lui, R. and Lypova, Iryna and Marandon, Vincent and Marcowith, Alexandre and Mariaud, C. and Marx, R. and Maurin, G. and Maxted, N. and Mayer, Michael and Meintjes, Petrus Johannes and Menzler, U. and Meyer, Manuel and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mora, K. and Moulin, Emmanuel and Murach, T. and de Naurois, Mathieu and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, Hirokazu and Ohm, Stefan and Oettl, S. and Ostrowski, M. and Oya, I. and Padovani, Marco and Panter, M. and Parsons, R. D. and Arribas, M. Paz and Pekeur, N. W. and Pelletier, G. and Petrucci, P. -O. and Peyaud, B. and Pita, S. and Poon, Helen and Prokhorov, Dmitry and Prokoph, Heike and Puehlhofer, Gerd and Punch, Michael and Quirrenbach, Andreas and Raab, S. and Reimer, Anita and Reimer, Olaf and Renaud, M. and de los Reyes, R. and Rieger, Frank and Romoli, Carlo and Rosier-Lees, S. and Rowell, G. and Rudak, B. and Rulten, C. B. and Sahakian, V. and Salek, David and Sanchez, David A. and Santangelo, Andrea and Sasaki, Manami and Schlickeiser, Reinhard and Schussler, F. and Schulz, Andreas and Schwanke, U. and Schwemmer, S. and Seyffert, A. S. and Shafi, N. and Simoni, R. and Sol, H. and Spanier, Felix and Spengler, G. and Spiess, F. and Stawarz, Lukasz and Steenkamp, R. and Stegmann, Christian and Stinzing, F. and Stycz, K. and Sushch, Iurii and Tavernet, J. -P. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tluczykont, Martin and Trichard, C. and Tuffs, R. and van der Walt, Johan and van Eldik, Christopher and van Soelen, Brian and Vasileiadis, Georges and Veh, J. and Venter, C. and Viana, A. and Vincent, P. and Vink, Jacco and Voisin, F. and Voelk, Heinrich J. and Vuillaume, Thomas and Wadiasingh, Z. and Wagner, Stefan J. and Wagner, P. and Wagner, R. M. and White, R. and Wierzcholska, Alicja and Willmann, P. and Woernlein, A. and Wouters, Denis and Yang, R. and Zabalza, Victor and Zaborov, D. and Zacharias, M. and Zdziarski, A. A. and Zech, Andreas and Zefi, F. and Ziegler, A. and Zywucka, Natalia},
  title     = {Search for Dark Matter Annihilations towards the Inner Galactic Halo from 10 Years of Observations with HESS},
  series = {Physical review letters},
  volume    = {117},
  journal   = {Physical review letters},
  publisher = {American Physical Society},
  address   = {College Park},
  organization    = {HESS Collaboration},
  issn      = {0031-9007},
  doi       = {10.1103/PhysRevLett.117.111301},
  pages     = {6},
  year      = {2016},
  abstract  = {The inner region of the Milky Way halo harbors a large amount of dark matter (DM). Given its proximity, it is one of the most promising targets to look for DM. We report on a search for the annihilations of DM particles using gamma-ray observations towards the inner 300 pc of the Milky Way, with the H.E.S.S. array of ground-based Cherenkov telescopes. The analysis is based on a 2D maximum likelihood method using Galactic Center (GC) data accumulated by H.E.S.S. over the last 10 years (2004-2014), and does not show any significant gamma-ray signal above background. Assuming Einasto and Navarro-Frenk-White DM density profiles at the GC, we derive upper limits on the annihilation cross section <sigma nu >. These constraints are the strongest obtained so far in the TeV DM mass range and improve upon previous limits by a factor 5. For the Einasto profile, the constraints reach <sigma nu > values of 6 x 10(-26) cm(3) s(-1) in the W+W- channel for a DM particle mass of 1.5 TeV, and 2 x 10(-26) cm(3) s(-1) in the tau(+)tau(-) channel for a 1 TeV mass. For the first time, ground-based gamma-ray observations have reached sufficient sensitivity to probe <sigma nu > values expected from the thermal relic density for TeV DM particles.},
  language  = {en}
}
@misc{SendGillesCoddetal.2018,
  author    = {Send, T. S. and Gilles, M. and Codd, V. and Wolf, I. A. C. and Bardtke, S. and Streit, Fabian and Strohmaier, Jana and Frank, Josef and Schendel, D. and Sutterlin, M. W. and Denniff, M. and Laucht, Manfred and Samani, N. J. and Deuschle, Michael and Rietschel, Marcella and Witt, Stephanie H.},
  title     = {Telomere length in newborns is related to maternal stress during pregnancy Response},
  series = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  volume    = {43},
  journal   = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  number    = {11},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {0893-133X},
  doi       = {10.1038/s41386-018-0079-8},
  pages     = {2164 -- 2164},
  year      = {2018},
  language  = {en}
}
@article{WittFrankGillesetal.2018,
  author    = {Witt, Stephanie H. and Frank, Josef and Gilles, Maria and Lang, Maren and Treutlein, Jens and Streit, Fabian and Wolf, Isabell A. C. and Peus, Verena and Scharnholz, Barbara and Send, Tabea S. and Heilmann-Heimbach, Stefanie and Sivalingam, Sugirthan and Dukal, Helene and Strohmaier, Jana and S{\"u}tterlin, Marc and Arloth, Janine and Laucht, Manfred and N{\"o}then, Markus M. and Deuschle, Michael and Rietschel, Marcella},
  title     = {Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation},
  series = {BMC genomics},
  volume    = {19},
  journal   = {BMC genomics},
  publisher = {BMC},
  address   = {London},
  issn      = {1471-2164},
  doi       = {10.1186/s12864-018-4652-7},
  pages     = {10},
  year      = {2018},
  abstract  = {Background: Cigarette smoking has severe adverse health consequences in adults and in the offspring of mothers who smoke during pregnancy. One of the most widely reported effects of smoking during pregnancy is reduced birth weight which is in turn associated with chronic disease in adulthood. Epigenome-wide association studies have revealed that smokers show a characteristic "smoking methylation pattern", and recent authors have proposed that DNA methylation mediates the impact of maternal smoking on birth weight. The aims of the present study were to replicate previous reports that methylation mediates the effect of maternal smoking on birth weight, and for the first time to investigate whether the observed mediation effects are sex-specific in order to account for known sex-specific differences in methylation levels. Methods: Methylation levels in the cord blood of 313 newborns were determined using the Illumina HumanMethylation450K Beadchip. A total of 5,527 CpG sites selected on the basis of evidence from the literature were tested. To determine whether the observed association between maternal smoking and birth weight was attributable to methylation, mediation analyses were performed for significant CpG sites. Separate analyses were then performed in males and females. Results: Following quality control, 282 newborns eventually remained in the analysis. A total of 25 mothers had smoked consistently throughout the pregnancy. The birthweigt of newborns whose mothers had smoked throughout pregnancy was reduced by >200g. After correction for multiple testing, 30 CpGs showed differential methylation in the maternal smoking subgroup including top "smoking methylation pattern" genes AHRR, MYO1G, GFI1, CYP1A1, and CNTNAP2. The effect of maternal smoking on birth weight was partly mediated by the methylation of cg25325512 (PIM1); cg25949550 (CNTNAP2); and cg08699196 (ITGB7). Sex-specific analyses revealed a mediating effect for cg25949550 (CNTNAP2) in male newborns. Conclusion: The present data replicate previous findings that methylation can mediate the effect of maternal smoking on birth weight. The analysis of sex-dependent mediation effects suggests that the sex of the newborn may have an influence. Larger studies are warranted to investigate the role of both the identified differentially methylated loci and the sex of the newborn in mediating the association between maternal smoking during pregnancy and birth weight.},
  language  = {en}
}
@article{SendBardtkeGillesetal.2019,
  author    = {Send, Tabea and Bardtke, S. and Gilles, M. and Wolf, I. A. C. and S{\"u}tterlin, Marc Wolf and Wudy, S. A. and Wang, R. and Laucht, Manfred and Witt, Stephanie H. and Rietschel, Marcella and Streit, Fabian and Deuschle, Michael},
  title     = {Prenatal maternal stress is associated with lower cortisol and cortisone levels in the first morning urine of 45-month-old children},
  series = {Psychoneuroendocrinology},
  volume    = {103},
  journal   = {Psychoneuroendocrinology},
  publisher = {Elsevier},
  address   = {Oxford},
  issn      = {0306-4530},
  doi       = {10.1016/j.psyneuen.2019.01.017},
  pages     = {219 -- 224},
  year      = {2019},
  abstract  = {Prenatal stress (PS) has been related to altered hypothalamic-pituitary-adrenal (HPA) axis activity later in life. So far, studies in children assessing HPA axis functioning have focused on salivary cortisol, reflecting daytime activity. The present work is part of a prospective study and aims to extend knowledge about the association between PS and HPA axis regulation in children. To do so, we investigated cortisol, cortisone, and the ratio cortisone/(cortisone + cortisol) in the first morning urine of 45-month-old children in relation to several measures of maternal stress during pregnancy. Urinary cortisol and cortisone were measured by online turbulent flow chromatography coupled with high performance liquid chromatography-tandem mass spectrometry. PS was defined as: perceived stress for aim 1 (Perceived Stress Scale; n = 280); presence of self-reported (n = 371) and expert-rated psychopathology for aim 2 (Mini International Neuropsychiatric Interview; n = 281); continuous measures of anxiety and depression for exploratory aim 3 (State-Trait Anxiety Inventory and Edinburgh Postnatal Depression Scale; n = 280). The ratio cortisone/(cortisone + cortisol) as a global marker for the balance between the enzymes metabolizing cortisol to cortisone and vice versa (11 beta-hydroxysteroid dehydrogenases type 1 and 2; 11 beta-HSD1 and 2) was not associated with any measure of maternal PS (aims 1-3). The present study provides insight into possible programming effects of PS on nocturnal HPA axis activity and a proxy of 11 beta-HSD in a large sample. The results suggest that the nocturnal rate of cortisol production is lower in children exposed to PS, but do not support the hypothesis of divergent 11 beta-HSD activity.},
  language  = {en}
}
@article{MiethKloftRodriguezetal.2016,
  author    = {Mieth, Bettina and Kloft, Marius and Rodriguez, Juan Antonio and Sonnenburg, Soren and Vobruba, Robin and Morcillo-Suarez, Carlos and Farre, Xavier and Marigorta, Urko M. and Fehr, Ernst and Dickhaus, Thorsten and Blanchard, Gilles and Schunk, Daniel and Navarro, Arcadi and M{\"u}ller, Klaus-Robert},
  title     = {Combining Multiple Hypothesis Testing with Machine Learning Increases the Statistical Power of Genome-wide Association Studies},
  series = {Scientific reports},
  volume    = {6},
  journal   = {Scientific reports},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/srep36671},
  pages     = {14},
  year      = {2016},
  abstract  = {The standard approach to the analysis of genome-wide association studies (GWAS) is based on testing each position in the genome individually for statistical significance of its association with the phenotype under investigation. To improve the analysis of GWAS, we propose a combination of machine learning and statistical testing that takes correlation structures within the set of SNPs under investigation in a mathematically well-controlled manner into account. The novel two-step algorithm, COMBI, first trains a support vector machine to determine a subset of candidate SNPs and then performs hypothesis tests for these SNPs together with an adequate threshold correction. Applying COMBI to data from a WTCCC study (2007) and measuring performance as replication by independent GWAS published within the 2008-2015 period, we show that our method outperforms ordinary raw p-value thresholding as well as other state-of-the-art methods. COMBI presents higher power and precision than the examined alternatives while yielding fewer false (i.e. non-replicated) and more true (i.e. replicated) discoveries when its results are validated on later GWAS studies. More than 80\% of the discoveries made by COMBI upon WTCCC data have been validated by independent studies. Implementations of the COMBI method are available as a part of the GWASpi toolbox 2.0.},
  language  = {en}
}