@article{WarringtonBeaumontHorikoshietal.2019, author = {Warrington, Nicole and Beaumont, Robin and Horikoshi, Momoko and Day, Felix R. and Helgeland, {\O}yvind and Laurin, Charles and Bacelis, Jonas and Peng, Shouneng and Hao, Ke and Feenstra, Bjarke and Wood, Andrew R. and Mahajan, Anubha and Tyrrell, Jessica and Robertson, Neil R. and Rayner, N. William and Qiao, Zhen and Moen, Gunn-Helen and Vaudel, Marc and Marsit, Carmen and Chen, Jia and Nodzenski, Michael and Schnurr, Theresia M. and Zafarmand, Mohammad Hadi and Bradfield, Jonathan P. and Grarup, Niels and Kooijman, Marjolein N. and Li-Gao, Ruifang and Geller, Frank and Ahluwalia, Tarunveer Singh and Paternoster, Lavinia and Rueedi, Rico and Huikari, Ville and Hottenga, Jouke-Jan and Lyytik{\"a}inen, Leo-Pekka and Cavadino, Alana and Metrustry, Sarah and Cousminer, Diana L. and Wu, Ying and Thiering, Elisabeth Paula and Wang, Carol A. and Have, Christian Theil and Vilor-Tejedor, Natalia and Joshi, Peter K. and Painter, Jodie N. and Ntalla, Ioanna and Myhre, Ronny and Pitk{\"a}nen, Niina and van Leeuwen, Elisabeth M. and Joro, Raimo and Lagou, Vasiliki and Richmond, Rebecca C. and Espinosa, Ana and Barton, Sheila J. and Inskip, Hazel M. and Holloway, John W. and Santa-Marina, Loreto and Estivill, Xavier and Ang, Wei and Marsh, Julie A. and Reichetzeder, Christoph and Marullo, Letizia and Hocher, Berthold and Lunetta, Kathryn L. and Murabito, Joanne M. and Relton, Caroline L. and Kogevinas, Manolis and Chatzi, Leda and Allard, Catherine and Bouchard, Luigi and Hivert, Marie-France and Zhang, Ge and Muglia, Louis J. and Heikkinen, Jani and Morgen, Camilla S. and van Kampen, Antoine H. C. and van Schaik, Barbera D. C. and Mentch, Frank D. and Langenberg, Claudia and Scott, Robert A. and Zhao, Jing Hua and Hemani, Gibran and Ring, Susan M. and Bennett, Amanda J. and Gaulton, Kyle J. and Fernandez-Tajes, Juan and van Zuydam, Natalie R. and Medina-Gomez, Carolina and de Haan, Hugoline G. and Rosendaal, Frits R. and Kutalik, Zolt{\´a}n and Marques-Vidal, Pedro and Das, Shikta and Willemsen, Gonneke and Mbarek, Hamdi and M{\"u}ller-Nurasyid, Martina and Standl, Marie and Appel, Emil V. R. and Fonvig, Cilius Esmann and Trier, Caecilie and van Beijsterveldt, Catharina E. M. and Murcia, Mario and Bustamante, Mariona and Bon{\`a}s-Guarch, S{\´i}lvia and Hougaard, David M. and Mercader, Josep M. and Linneberg, Allan and Schraut, Katharina E. and Lind, Penelope A. and Medland, Sarah Elizabeth and Shields, Beverley M. and Knight, Bridget A. and Chai, Jin-Fang and Panoutsopoulou, Kalliope and Bartels, Meike and S{\´a}nchez, Friman and Stokholm, Jakob and Torrents, David and Vinding, Rebecca K. and Willems, Sara M. and Atalay, Mustafa and Chawes, Bo L. and Kovacs, Peter and Prokopenko, Inga and Tuke, Marcus A. and Yaghootkar, Hanieh and Ruth, Katherine S. and Jones, Samuel E. and Loh, Po-Ru and Murray, Anna and Weedon, Michael N. and T{\"o}njes, Anke and Stumvoll, Michael and Michaelsen, Kim Fleischer and Eloranta, Aino-Maija and Lakka, Timo A. and van Duijn, Cornelia M. and Kiess, Wieland and Koerner, Antje and Niinikoski, Harri and Pahkala, Katja and Raitakari, Olli T. and Jacobsson, Bo and Zeggini, Eleftheria and Dedoussis, George V. and Teo, Yik-Ying and Saw, Seang-Mei and Montgomery, Grant W. and Campbell, Harry and Wilson, James F. and Vrijkotte, Tanja G. M. and Vrijheid, Martine and de Geus, Eco J. C. N. and Hayes, M. Geoffrey and Kadarmideen, Haja N. and Holm, Jens-Christian and Beilin, Lawrence J. and Pennell, Craig E. and Heinrich, Joachim and Adair, Linda S. and Borja, Judith B. and Mohlke, Karen L. and Eriksson, Johan G. and Widen, Elisabeth E. and Hattersley, Andrew T. and Spector, Tim D. and Kaehoenen, Mika and Viikari, Jorma S. and Lehtimaeki, Terho and Boomsma, Dorret I. and Sebert, Sylvain and Vollenweider, Peter and Sorensen, Thorkild I. A. and Bisgaard, Hans and Bonnelykke, Klaus and Murray, Jeffrey C. and Melbye, Mads and Nohr, Ellen A. and Mook-Kanamori, Dennis O. and Rivadeneira, Fernando and Hofman, Albert and Felix, Janine F. and Jaddoe, Vincent W. V. and Hansen, Torben and Pisinger, Charlotta and Vaag, Allan A. and Pedersen, Oluf and Uitterlinden, Andre G. and Jarvelin, Marjo-Riitta and Power, Christine and Hypponen, Elina and Scholtens, Denise M. and Lowe, William L. and Smith, George Davey and Timpson, Nicholas J. and Morris, Andrew P. and Wareham, Nicholas J. and Hakonarson, Hakon and Grant, Struan F. A. and Frayling, Timothy M. and Lawlor, Debbie A. and Njolstad, Pal R. and Johansson, Stefan and Ong, Ken K. and McCarthy, Mark I. and Perry, John R. B. and Evans, David M. and Freathy, Rachel M.}, title = {Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors}, series = {Nature genetics}, volume = {51}, journal = {Nature genetics}, number = {5}, publisher = {Nature Publ. Group}, address = {New York}, organization = {EGG Consortium}, issn = {1061-4036}, pages = {804 -- +}, year = {2019}, abstract = {Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.}, language = {en} } @article{AbdallaAharonianBenkhalietal.2019, author = {Abdalla, Hassan E. and Aharonian, Felix A. and Benkhali, F. Ait and Anguener, E. O. and Arakawa, M. and Arcaro, C. and Armand, C. and Ashkar, H. and Backes, M. and Martins, V. Barbosa and Barnard, M. and Becherini, Y. and Berge, D. and Bernloehr, K. and Blackwell, R. and Boettcher, M. and Boisson, C. and Bolmont, J. and Bonnefoy, S. and Bregeon, J. and Breuhaus, M. and Brun, F. and Brun, P. and Bryan, M. and Buechele, M. and Bulik, T. and Bylund, T. and Capasso, M. and Caroff, S. and Carosi, A. and Casanova, Sabrina and Cerruti, M. and Chakraborty, N. and Chand, T. and Chandra, S. and Chaves, R. C. G. and Chen, A. and Colafrancesco, S. and Curylo, M. and Davids, I. D. and Deil, C. and Devin, J. and de Wilt, P. and Dirson, L. and Djannati-Atai, A. and Dmytriiev, A. and Donath, A. and Doroshenko, V and Dyks, J. and Egberts, Kathrin and Emery, G. and Ernenwein, J-p and Eschbach, S. and Feijen, K. and Fegan, S. and Fiasson, A. and Fontaine, G. and Funk, S. and Fuessling, M. and Gabici, S. and Gallant, Y. A. and Gate, F. and Giavitto, G. and Glawion, D. and Glicenstein, J. F. and Gottschall, D. and Grondin, M-H and Hahn, J. and Haupt, M. and Heinzelmann, G. and Henri, G. and Hermann, G. and Hinton, James Anthony and Hofmann, W. and Hoischen, Clemens and Holch, Tim Lukas and Holler, M. and Horns, D. and Huber, D. and Iwasaki, H. and Jamrozy, M. and Jankowsky, D. and Jankowsky, F. and Jung-Richardt, I and Kastendieck, M. A. and Katarzynski, K. and Katsuragawa, M. and Katz, U. and Khangulyan, D. and Khelifi, B. and King, J. and Klepser, S. and Kluzniak, W. and Komin, Nu and Kosack, K. and Kostunin, D. and Kraus, M. and Lamanna, G. and Lau, J. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J-P and Leser, Eva and Levy, C. and Lohse, T. and Lopez-Coto, R. and Lypova, I and Mackey, J. and Majumdar, J. and Malyshev, D. and Marandon, V and Marcowith, Alexandre and Mares, A. and Mariaud, C. and Marti-Devesa, G. and Marx, R. and Maurin, G. and Meintjes, P. J. and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Muller, J. and Moore, C. and Moulin, Emmanuel and Murach, T. and Nakashima, S. and de Naurois, M. and Ndiyavala, H. and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, H. and Ohm, S. and Wilhelmi, E. de Ona and Ostrowski, M. and Oya, I and Panter, M. and Parsons, R. D. and Perennes, C. and Petrucci, P-O and Peyaud, B. and Piel, Q. and Pita, S. and Poireau, V and Noel, A. Priyana and Prokhorov, D. A. and Prokoph, H. and Puehlhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Rauth, R. and Reimer, A. and Reimer, O. and Remy, Q. and Renaud, M. and Rieger, F. and Rinchiuso, L. and Romoli, C. and Rowell, G. and Rudak, B. and Ruiz-Velasco, E. and Sahakian, V and Saito, S. and Sanchez, David M. and Santangelo, A. and Sasaki, M. and Schlickeiser, R. and Schussler, F. and Schulz, A. and Schutte, H. and Schwanke, U. and Schwemmer, S. and Seglar-Arroyo, M. and Senniappan, M. and Seyffert, A. S. and Shafi, N. and Shiningayamwe, K. and Simoni, R. and Sinha, A. and Sol, H. and Specovius, A. and Spir-Jacob, M. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steppa, Constantin Beverly and Takahashi, T. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tiziani, D. and Tluczykont, M. and Trichard, C. and Tsirou, M. and Tsuji, N. and Tuffs, R. and Uchiyama, Y. and van der Walt, D. J. and van Eldik, C. and van Rensburg, C. and van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Vincent, P. and Vink, J. and Voisin, F. and Voelk, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and White, R. and Wierzcholska, A. and Yang, R. and Yoneda, H. and Zacharias, M. and Zanin, R. and Zdziarski, A. A. and Zech, Alraune and Ziegler, A. and Zorn, J. and Zywucka, N. and Maxted, N.}, title = {Upper limits on very-high-energy gamma-ray emission from core-collapse supernovae observed with H.E.S.S.}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {626}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, organization = {HESS Collaboration}, issn = {1432-0746}, doi = {10.1051/0004-6361/201935242}, pages = {11}, year = {2019}, abstract = {Young core-collapse supernovae with dense-wind progenitors may be able to accelerate cosmic-ray hadrons beyond the knee of the cosmic-ray spectrum, and this may result in measurable gamma-ray emission. We searched for gamma-ray emission from ten super- novae observed with the High Energy Stereoscopic System (H.E.S.S.) within a year of the supernova event. Nine supernovae were observed serendipitously in the H.E.S.S. data collected between December 2003 and December 2014, with exposure times ranging from 1.4 to 53 h. In addition we observed SN 2016adj as a target of opportunity in February 2016 for 13 h. No significant gamma-ray emission has been detected for any of the objects, and upper limits on the >1 TeV gamma-ray flux of the order of similar to 10(-13) cm(-)(2)s(-1) are established, corresponding to upper limits on the luminosities in the range similar to 2 x 10(39) to similar to 1 x 10(42) erg s(-1). These values are used to place model-dependent constraints on the mass-loss rates of the progenitor stars, implying upper limits between similar to 2 x 10(-5) and similar to 2 x 10(-3) M-circle dot yr(-1) under reasonable assumptions on the particle acceleration parameters.}, language = {en} } @article{GrottKnollenbergHammetal.2019, author = {Grott, Matthias and Knollenberg, J. and Hamm, M. and Ogawa, K. and Jaumann, R. and Otto, Katharina Alexandra and Delbo, M. and Michel, P. and Biele, J. and Neumann, W. and Knapmeyer, M. and Kuehrt, E. and Senshu, H. and Okada, T. and Helbert, J. and Maturilli, A. and M{\"u}ller, N. and Hagermann, A. and Sakatani, N. and Tanaka, S. and Arai, T. and Mottola, S. and Tachibana, S. and Pelivan, Ivanka and Drube, L. and Vincent, J-B and Yano, H. and Pilorget, C. and Matz, K. D. and Schmitz, N. and Koncz, A. and Schr{\"o}der, S. E. and Trauthan, F. and Schlotterer, M. and Krause, C. and Ho, T-M and Moussi-Soffys, A.}, title = {Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu}, series = {Nature astronomy}, volume = {3}, journal = {Nature astronomy}, number = {11}, publisher = {Nature Publishing Group}, address = {London}, issn = {2397-3366}, doi = {10.1038/s41550-019-0832-x}, pages = {971 -- 976}, year = {2019}, abstract = {C-type asteroids are among the most pristine objects in the Solar System, but little is known about their interior structure and surface properties. Telescopic thermal infrared observations have so far been interpreted in terms of a regolith-covered surface with low thermal conductivity and particle sizes in the centimetre range. This includes observations of C-type asteroid (162173) Ryugu1,2,3. However, on arrival of the Hayabusa2 spacecraft at Ryugu, a regolith cover of sand- to pebble-sized particles was found to be absent4,5 (R.J. et al., manuscript in preparation). Rather, the surface is largely covered by cobbles and boulders, seemingly incompatible with the remote-sensing infrared observations. Here we report on in situ thermal infrared observations of a boulder on the C-type asteroid Ryugu. We found that the boulder's thermal inertia was much lower than anticipated based on laboratory measurements of meteorites, and that a surface covered by such low-conductivity boulders would be consistent with remote-sensing observations. Our results furthermore indicate high boulder porosities as well as a low tensile strength in the few hundred kilopascal range. The predicted low tensile strength confirms the suspected observational bias6 in our meteorite collections, as such asteroidal material would be too frail to survive atmospheric entry7.}, language = {en} } @article{AbdallaAdamAharonianetal.2019, author = {Abdalla, Hassan E. and Adam, R. and Aharonian, Felix A. and Benkhali, F. Ait and Ang{\"u}ner, Ekrem Oǧuzhan and Arakawa, M. and Arcaro, C. and Armand, C. and Ashkar, H. and Backes, M. and Martins, V. Barbosa and Barnard, M. and Becherini, Y. and Berge, D. and Bernloehr, K. and Blackwell, R. and B{\"o}ttcher, M. and Boisson, C. and Bolmont, J. and Bonnefoy, S. and Bregeon, J. and Breuhaus, M. and Brun, F. and Brun, P. and Bryan, M. and B{\"u}chele, M. and Bulik, T. and Bylund, T. and Capasso, M. and Caroff, S. and Carosi, A. and Casanova, Sabrina and Cerruti, M. and Chand, T. and Chandra, S. and Chen, A. and Colafrancesco, S. and Curylo, M. and Davids, I. D. and Deil, C. and Devin, J. and DeWilt, P. and Dirson, L. and Djannati-Ata, A. and Dmytriiev, A. and Donath, A. and Doroshenko, V and Dyks, J. and Egberts, Kathrin and Emery, G. and Ernenwein, J-P and Eschbach, S. and Feijen, K. and Fegan, S. and Fiasson, A. and Fontaine, G. and Funk, S. and F{\"u}ßling, Matthias and Gabici, S. and Gallant, Y. A. and Gate, F. and Giavitto, G. and Glawion, D. and Glicenstein, J. F. and Gottschall, D. and Grondin, M-H and Hahn, J. and Haupt, M. and Heinzelmann, G. and Henri, G. and Hermann, G. and Hinton, James Anthony and Hofmann, W. and Hoischen, Clemens and Holch, Tim Lukas and Holler, M. and Horns, D. and Huber, D. and Iwasaki, H. and Jamrozy, M. and Jankowsky, D. and Jankowsky, F. and Jardin-Blicq, A. and Jung-Richardt, I and Kastendieck, M. A. and Katarzynski, K. and Katsuragawa, M. and Katz, U. and Khangulyan, D. and Khelifi, B. and King, J. and Klepser, S. and Kluzniak, W. and Komin, Nu and Kosack, K. and Kostunin, D. and Kraus, M. and Lamanna, G. and Lau, J. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J-P and Leser, Eva and Levy, C. and Lohse, T. and Lypova, I and Mackey, J. and Majumdar, J. and Malyshev, D. and Marandon, V and Marcowith, Alexandre and Mares, A. and Mariaud, C. and Marti-Devesa, G. and Marx, R. and Maurin, G. and Meintjes, P. J. and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Moore, C. and Moulin, Emmanuel and Muller, J. and Murach, T. and Nakashima, S. and de Naurois, M. and Ndiyavala, H. and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, H. and Ohm, S. and Wilhelmi, E. de Ona and Ostrowski, M. and Oya, I and Panter, M. and Parsons, R. D. and Perennes, C. and Petrucci, P-O and Peyaud, B. and Piel, Q. and Pita, S. and Poireau, V and Priyana Noel, A. and Prokhorov, D. A. and Prokoph, H. and P{\"u}hlhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Rauth, R. and Reimer, A. and Reimer, O. and Remy, Q. and Renaud, M. and Rieger, F. and Rinchiuso, L. and Romoli, C. and Rowell, G. and Rudak, B. and Ruiz-Velasco, E. and Sahakian, V and Saito, S. and Sanchez, David M. and Santangelo, A. and Sasaki, M. and Schlickeiser, R. and Sch{\"u}ssler, F. and Schulz, A. and Schutte, H. and Schwanke, U. and Schwemmer, S. and Seglar-Arroyo, M. and Senniappan, M. and Seyffert, A. S. and Shafi, N. and Shiningayamwe, K. and Simoni, R. and Sinha, A. and Sol, H. and Specovius, A. and Spir-Jacob, M. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steppa, Constantin Beverly and Takahashi, T. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tiziani, D. and Tluczykont, M. and Trichard, C. and Tsirou, M. and Tsuji, N. and Tuffs, R. and Uchiyama, Y. and van Der Walt, D. J. and van Eldik, C. and van Rensburg, C. and van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Vincent, P. and Vink, J. and Voisin, F. and Voelk, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and White, R. and Wierzcholska, A. and Yang, R. and Yoneda, H. and Zacharias, Michael and Zanin, R. and Zdziarski, A. A. and Zech, Alraune and Ziegler, A. and Zorn, J. and Zywucka, N. and Meyer, M.}, title = {Constraints on the emission region of 3C 279 during strong flares in 2014 and 2015 through VHE gamma-ray observations with HESS}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {627}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, organization = {HESS Collaboration}, issn = {1432-0746}, doi = {10.1051/0004-6361/201935704}, pages = {19}, year = {2019}, abstract = {The flat spectrum radio quasar 3C 279 is known to exhibit pronounced variability in the high-energy (100MeV < E < 100 GeV) gamma-ray band, which is continuously monitored with Fermi-LAT. During two periods of high activity in April 2014 and June 2015 target-of-opportunity observations were undertaken with the High Energy Stereoscopic System (H.E.S.S.) in the very-high-energy (VHE, E > 100 GeV) gamma-ray domain. While the observation in 2014 provides an upper limit, the observation in 2015 results in a signal with 8 : 7 sigma significance above an energy threshold of 66 GeV. No VHE variability was detected during the 2015 observations. The VHE photon spectrum is soft and described by a power-law index of 4.2 +/- 0.3. The H.E.S.S. data along with a detailed and contemporaneous multiwavelength data set provide constraints on the physical parameters of the emission region. The minimum distance of the emission region from the central black hole was estimated using two plausible geometries of the broad-line region and three potential intrinsic spectra. The emission region is confidently placed at r greater than or similar to 1 : 7 X 1017 cm from the black hole, that is beyond the assumed distance of the broad-line region. Time-dependent leptonic and lepto-hadronic one-zone models were used to describe the evolution of the 2015 flare. Neither model can fully reproduce the observations, despite testing various parameter sets. Furthermore, the H.E.S.S. data were used to derive constraints on Lorentz invariance violation given the large redshift of 3C 279.}, language = {en} } @article{AbdallaAdamAharonianetal.2019, author = {Abdalla, Hassan E. and Adam, R. and Aharonian, Felix A. and Benkhali, F. Ait and Ang{\"u}ner, Ekrem Oǧuzhan and Arakawa, M. and Arcaro, C. and Armand, C. and Ashkar, H. and Backes, M. and Martins, V. Barbosa and Barnard, M. and Becherini, Y. and Berge, D. and Bernloehr, K. and Bissaldi, E. and Blackwell, R. and Boettcher, M. and Boisson, C. and Bolmont, J. and Bonnefoy, S. and Bregeon, J. and Breuhaus, M. and Brun, F. and Brun, P. and Bryan, M. and Buechele, M. and Bulik, T. and Bylund, T. and Capasso, M. and Caroff, S. and Carosi, A. and Casanova, Sabrina and Cerruti, M. and Chand, T. and Chandra, S. and Chen, A. and Colafrancesco, S. and Curylo, M. and Davids, I. D. and Deil, C. and Devin, J. and deWilt, P. and Dirson, L. and Djannati-Atai, A. and Dmytriiev, A. and Donath, A. and Doroshenko, V and Dyks, J. and Egberts, Kathrin and Emery, G. and Ernenwein, J-P and Eschbach, S. and Feijen, K. and Fegan, S. and Fiasson, A. and Fontaine, G. and Funk, S. and Fussling, Matthias and Gabici, S. and Gallant, Y. A. and Gate, F. and Giavitto, G. and Giunti, L. and Glawion, D. and Glicenstein, J. F. and Gottschall, D. and Grondin, M-H and Hahn, J. and Haupt, M. and Heinzelmann, G. and Henri, G. and Hermann, G. and Hinton, J. A. and Hofmann, W. and Hoischen, Clemens and Holch, T. L. and Holler, M. and Horns, D. and Huber, D. and Iwasaki, H. and Jamrozy, M. and Jankowsky, D. and Jankowsky, F. and Jardin-Blicq, A. and Jung-Richardt, I and Kastendieck, M. A. and Katarzynski, K. and Katsuragawa, M. and Katz, U. and Khangulyan, D. and Khelifi, B. and King, J. and Klepser, S. and Kluzniak, W. and Komin, Nu and Kosack, K. and Kostunin, D. and Kreter, M. and Lamanna, G. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J-P and Leser, Eva and Levy, C. and Lohse, T. and Lypova, I and Mackey, J. and Majumdar, J. and Malyshev, D. and Marandon, V and Marcowith, Alexandre and Mares, A. and Mariaud, C. and Marti-Devesa, G. and Marx, R. and Maurin, G. and Meintjes, P. J. and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Moore, C. and Moulin, Emmanuel and Muller, J. and Murach, T. and Nakashima, S. and de Naurois, M. and Ndiyavala, H. and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, H. and Ohm, S. and Wilhelmi, E. de Ona and Ostrowski, M. and Oya, I and Panter, M. and Parsons, R. D. and Perennes, C. and Petrucci, P-O and Peyaud, B. and Piel, Q. and Pita, S. and Poireau, V and Noel, A. Priyana and Prokhorov, D. A. and Prokoph, H. and Puehlhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Rauth, R. and Reimer, A. and Reimer, O. and Remy, Q. and Renaud, M. and Rieger, F. and Rinchiuso, L. and Romoli, C. and Rowell, G. and Rudak, B. and Ruiz-Velasco, E. and Sahakian, V and Sailer, S. and Saito, S. and Sanchez, D. A. and Santangelo, A. and Sasaki, M. and Schlickeiser, R. and Schussler, F. and Schulz, A. and Schutte, H. M. and Schwanke, U. and Schwemmer, S. and Seglar-Arroyo, M. and Senniappan, M. and Seyffert, A. S. and Shafi, N. and Shiningayamwe, K. and Simoni, R. and Sinha, A. and Sol, H. and Specovius, A. and Spir-Jacob, M. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steppa, Constantin Beverly and Takahashi, T. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tiziani, D. and Tluczykont, M. and Trichard, C. and Tsirou, M. and Tsuji, N. and Tuffs, R. and Uchiyama, Y. and van der Walt, D. J. and van Eldik, C. and van Rensburg, C. and van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Vincent, P. and Vink, J. and Voelk, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and White, R. and Wierzcholska, A. and Yang, R. and Yoneda, H. and Zacharias, M. and Zanin, R. and Zdziarski, A. A. and Zech, Alraune and Ziegler, A. and Zorn, J. and Zywucka, N. and de Palma, F. and Axelsson, M. and Roberts, O. J.}, title = {A very-high-energy component deep in the gamma-ray burst afterglow}, series = {Nature : the international weekly journal of science}, volume = {575}, journal = {Nature : the international weekly journal of science}, number = {7783}, publisher = {Nature Publ. Group}, address = {London}, issn = {0028-0836}, doi = {10.1038/s41586-019-1743-9}, pages = {464 -- +}, year = {2019}, abstract = {Gamma-ray bursts (GRBs) are brief flashes of gamma-rays and are considered to be the most energetic explosive phenomena in the Universe(1). The emission from GRBs comprises a short (typically tens of seconds) and bright prompt emission, followed by a much longer afterglow phase. During the afterglow phase, the shocked outflow-produced by the interaction between the ejected matter and the circumburst medium-slows down, and a gradual decrease in brightness is observed(2). GRBs typically emit most of their energy via.-rays with energies in the kiloelectronvolt-to-megaelectronvolt range, but a few photons with energies of tens of gigaelectronvolts have been detected by space-based instruments(3). However, the origins of such high-energy (above one gigaelectronvolt) photons and the presence of very-high-energy (more than 100 gigaelectronvolts) emission have remained elusive(4). Here we report observations of very-high-energy emission in the bright GRB 180720B deep in the GRB afterglow-ten hours after the end of the prompt emission phase, when the X-ray flux had already decayed by four orders of magnitude. Two possible explanations exist for the observed radiation: inverse Compton emission and synchrotron emission of ultrarelativistic electrons. Our observations show that the energy fluxes in the X-ray and gamma-ray range and their photon indices remain comparable to each other throughout the afterglow. This discovery places distinct constraints on the GRB environment for both emission mechanisms, with the inverse Compton explanation alleviating the particle energy requirements for the emission observed at late times. The late timing of this detection has consequences for the future observations of GRBs at the highest energies.}, language = {en} } @article{TaranNunezValdezEfthimiopoulosetal.2019, author = {Taran, Michail N. and Nunez Valdez, Maribel and Efthimiopoulos, Ilias and M{\"u}ller, J. and Reichmann, Hans-Josef and Wilke, Max and Koch-M{\"u}ller, Monika}, title = {Spectroscopic and ab initio studies of the pressure-induced Fe2+ high-spin-to-low-spin electronic transition in natural triphylite-lithiophilite}, series = {Physics and Chemistry of Minerals}, volume = {46}, journal = {Physics and Chemistry of Minerals}, number = {3}, publisher = {Springer}, address = {New York}, issn = {0342-1791}, doi = {10.1007/s00269-018-1001-y}, pages = {245 -- 258}, year = {2019}, abstract = {Using optical absorption and Raman spectroscopic measurements, in conjunction with the first-principles calculations, a pressure-induced high-spin (HS)-to-low-spin (LS) state electronic transition of Fe2+ (M2-octahedral site) was resolved around 76-80GPa in a natural triphylite-lithiophilite sample with chemical composition (LiFe0.7082+Mn0.292PO4)-Li-M1-Fe-M2 (theoretical composition (LiFe0.52+Mn0.5PO4)-Li-M1-Fe-M2). The optical absorption spectra at ambient conditions consist of a broad doublet band with two constituents (1) (similar to 9330cm(-1)) and (2) (similar to 7110cm(-1)), resulting from the electronic spin-allowed transition (T2gEg)-T-5-E-5 of octahedral (HSFe2+)-Fe-M2. Both (1) and (2) bands shift non-linearly with pressure to higher energies up to similar to 55GPa. In the optical absorption spectrum measured at similar to 81GPa, the aforementioned HS-related bands disappear, whereas a new broadband with an intensity maximum close to 16,360cm(-1) appears, superimposed on the tail of the high-energy ligand-to-metal O2-Fe2+ charge-transfer absorption edge. We assign this new band to the electronic spin-allowed dd-transition (1)A(1g)(1)T(1g) of LS Fe2+ in octahedral coordination. The high-pressure Raman spectra evidence the Fe2+ HS-to-LS transition mainly from the abrupt shift of the P-O symmetric stretching modes to lower frequencies at similar to 76GPa, the highest pressure achieved in the Raman spectroscopic experiments. Calculations indicated that the presence of Mn-M2(2+) simply shifts the isostructural HS-to-LS transition to higher pressures compared to the triphylite Fe-M2(2+) end-member, in qualitative agreement with our experimental observations.}, language = {en} } @article{GrottKnollenbergHammetal.2019, author = {Grott, Matthias and Knollenberg, J. and Hamm, M. and Ogawa, K. and Jaumann, R. and Otto, Katharina Alexandra and Delbo, M. and Michel, Patrick and Biele, J. and Neumann, Wladimir and Knapmeyer, Martin and K{\"u}hrt, E. and Senshu, H. and Okada, T. and Helbert, Jorn and Maturilli, A. and M{\"u}ller, N. and Hagermann, A. and Sakatani, Naoya and Tanaka, S. and Arai, T. and Mottola, Stefano and Tachibana, Shogo and Pelivan, Ivanka and Drube, Line and Vincent, J-B and Yano, Hajime and Pilorget, C. and Matz, K. D. and Schmitz, N. and Koncz, A. and Schr{\"o}der, Stefan E. and Trauthan, F. and Schlotterer, Markus and Krause, C. and Ho, T-M and Moussi-Soffys, A.}, title = {Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu}, series = {Nature astronomy}, volume = {3}, journal = {Nature astronomy}, number = {11}, publisher = {Nature Publishing Group}, address = {London}, issn = {2397-3366}, doi = {10.1038/s41550-019-0832-x}, pages = {971 -- 976}, year = {2019}, abstract = {C-type asteroids are among the most pristine objects in the Solar System, but little is known about their interior structure and surface properties. Telescopic thermal infrared observations have so far been interpreted in terms of a regolith-covered surface with low thermal conductivity and particle sizes in the centimetre range. This includes observations of C-type asteroid (162173) Ryugu1,2,3. However, on arrival of the Hayabusa2 spacecraft at Ryugu, a regolith cover of sand- to pebble-sized particles was found to be absent4,5 (R.J. et al., manuscript in preparation). Rather, the surface is largely covered by cobbles and boulders, seemingly incompatible with the remote-sensing infrared observations. Here we report on in situ thermal infrared observations of a boulder on the C-type asteroid Ryugu. We found that the boulder's thermal inertia was much lower than anticipated based on laboratory measurements of meteorites, and that a surface covered by such low-conductivity boulders would be consistent with remote-sensing observations. Our results furthermore indicate high boulder porosities as well as a low tensile strength in the few hundred kilopascal range. The predicted low tensile strength confirms the suspected observational bias6 in our meteorite collections, as such asteroidal material would be too frail to survive atmospheric entry7}, language = {en} } @article{AbdallaAdamAharonianetal.2020, author = {Abdalla, H. and Adam, R. and Aharonian, Felix A. and Benkhali, F. Ait and Ang{\"u}ner, Ekrem Oǧuzhan and Arcaro, C. and Armand, C. and Armstrong, T. and Ashkar, H. and Backes, M. and Baghmanyan, V. and Martins, V. Barbosa and Barnacka, A. and Barnard, M. and Becherini, Y. and Berge, D. and Bernlohr, K. and Bi, B. and Bottcher, M. and Boisson, C. and Bolmont, J. and de Lavergne, M. de Bony and Bordas, Pol and Breuhaus, M. and Brun, F. and Brun, P. and Bryan, M. and Buchele, M. and Bulik, T. and Bylund, T. and Caroff, S. and Carosi, A. and Casanova, Sabrina and Chand, T. and Chandra, S. and Chen, A. and Cotter, G. and Curylo, M. and Mbarubucyeye, J. Damascene and Davids, I. D. and Davies, J. and Deil, C. and Devin, J. and deWilt, P. and Dirson, L. and Djannati-Atai, A. and Dmytriiev, A. and Donath, A. and Doroshenko, V. and Duffy, C. and Dyks, J. and Egberts, Kathrin and Eichhorn, F. and Einecke, S. and Emery, G. and Ernenwein, J. -P. and Feijen, K. and Fegan, S. and Fiasson, A. and de Clairfontaine, G. Fichet and Fontaine, G. and Funk, S. and Fussling, Matthias and Gabici, S. and Gallant, Y. A. and Giavitto, G. and Giunti, L. and Glawion, D. and Glicenstein, J. F. and Gottschall, D. and Grondin, M. -H. and Hahn, J. and Haupt, M. and Hermann, G. and Hinton, J. A. and Hofmann, W. and Hoischen, Clemens and Holch, T. L. and Holler, M. and Horbe, M. and Horns, D. and Huber, D. and Jamrozy, M. and Jankowsky, D. and Jankowsky, F. and Jardin-Blicq, A. and Joshi, V. and Jung-Richardt, I. and Kasai, E. and Kastendieck, M. A. and Katarzynski, K. and Katz, U. and Khangulyan, D. and Khelifi, B. and Klepser, S. and Kluzniak, W. and Komin, Nu. and Konno, R. and Kosack, K. and Kostunin, D. and Kreter, M. and Lamanna, G. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Levy, C. and Lohse, T. and Lypova, I. and Mackey, J. and Majumdar, J. and Malyshev, D. and Malyshev, D. and Marandon, V. and Marchegiani, P. and Marcowith, Alexandre and Mares, A. and Marti-Devesa, G. and Marx, R. and Maurin, G. and Meintjes, P. J. and Meyer, M. and Mitchell, A. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Montanari, A. and Moore, C. and Morris, P. and Moulin, Emmanuel and Muller, J. and Murach, T. and Nakashima, K. and Nayerhoda, A. and de Naurois, M. and Ndiyavala, H. and Niederwanger, F. and Niemiec, J. and Oakes, L. and O'Brien, Patrick and Odaka, H. and Ohm, S. and Olivera-Nieto, L. and Wilhelmi, E. de Ona and Ostrowski, M. and Oya, I. and Panter, M. and Panny, S. and Parsons, R. D. and Peron, G. and Peyaud, B. and Piel, Q. and Pita, S. and Poireau, V. and Noel, A. Priyana and Prokhorov, D. A. and Prokoph, H. and Puhlhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Rauth, R. and Reichherzer, P. and Reimer, A. and Reimer, O. and Remy, Q. and Renaud, M. and Rieger, F. and Rinchiuso, L. and Romoli, C. and Rowell, G. and Rudak, B. and Ruiz-Velasco, E. and Sahakian, V. and Sailer, S. and Sanchez, D. A. and Santangelo, A. and Sasaki, M. and Scalici, M. and Schussler, F. and Schutte, H. M. and Schwanke, U. and Schwemmer, S. and Seglar-Arroyo, M. and Senniappan, M. and Seyffert, A. S. and Shafi, N. and Shiningayamwe, K. and Simoni, R. and Sinha, A. and Sol, H. and Specovius, A. and Spencer, S. and Spir-Jacob, M. and Stawarz, L. and Sun, L. and Steenkamp, R. and Stegmann, C. and Steinmassl, S. and Steppa, C. and Takahashi, T. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tiziani, D. and Tluczykont, M. and Tomankova, L. and Trichard, C. and Tsirou, M. and Tuffs, R. and Uchiyama, Y. and van der Walt, D. J. and van Eldik, C. and van Rensburg, C. and van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Vincent, P. and Vink, J. and Volk, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and Watson, J. and Werner, F. and White, R. and Wierzcholska, A. and Wong, Yu Wun and Yusafzai, A. and Zacharias, M. and Zanin, R. and Zargaryan, D. and Zdziarski, A. A. and Zech, Alraune and Zhu, S. J. and Ziegler, A. and Zorn, J. and Zouari, S. and Zywucka, N.}, title = {An extreme particle accelerator in the Galactic plane}, series = {Astronomy and astrophysics : an international weekly journal}, volume = {644}, journal = {Astronomy and astrophysics : an international weekly journal}, publisher = {EDP Sciences}, address = {Les Ulis}, organization = {HESS Collaboration}, issn = {0004-6361}, doi = {10.1051/0004-6361/202038851}, pages = {8}, year = {2020}, abstract = {The unidentified very-high-energy (VHE; E > 0.1 TeV) gamma -ray source, HESS J1826-130, was discovered with the High Energy Stereoscopic System (HESS) in the Galactic plane. The analysis of 215 h of HESS data has revealed a steady gamma -ray flux from HESS J1826-130, which appears extended with a half-width of 0.21 degrees +/- 0.02
(stat)degrees
stat degrees +/- 0.05
(sys)degrees sys degrees . The source spectrum is best fit with either a power-law function with a spectral index Gamma = 1.78 +/- 0.10(stat) +/- 0.20(sys) and an exponential cut-off at 15.2
(+5.5)(-3.2) -3.2+5.5 TeV, or a broken power-law with Gamma (1) = 1.96 +/- 0.06(stat) +/- 0.20(sys), Gamma (2) = 3.59 +/- 0.69(stat) +/- 0.20(sys) for energies below and above E-br = 11.2 +/- 2.7 TeV, respectively. The VHE flux from HESS J1826-130 is contaminated by the extended emission of the bright, nearby pulsar wind nebula, HESS J1825-137, particularly at the low end of the energy spectrum. Leptonic scenarios for the origin of HESS J1826-130 VHE emission related to PSR J1826-1256 are confronted by our spectral and morphological analysis. In a hadronic framework, taking into account the properties of dense gas regions surrounding HESS J1826-130, the source spectrum would imply an astrophysical object capable of accelerating the parent particle population up to greater than or similar to 200 TeV. Our results are also discussed in a multiwavelength context, accounting for both the presence of nearby supernova remnants, molecular clouds, and counterparts detected in radio, X-rays, and TeV energies.}, language = {en} } @article{ShenoyKrauledatBlankertzetal.2006, author = {Shenoy, Pradeep and Krauledat, Matthias and Blankertz, Benjamin and Rao, Rajesh P. N. and M{\"u}ller, Klaus-Robert}, title = {Towards adaptive classification for BCI}, doi = {10.1088/1741-2560/3/1/R02}, year = {2006}, abstract = {Non-stationarities are ubiquitous in EEG signals. They are especially apparent in the use of EEG-based brain- computer interfaces (BCIs): (a) in the differences between the initial calibration measurement and the online operation of a BCI, or (b) caused by changes in the subject's brain processes during an experiment (e.g. due to fatigue, change of task involvement, etc). In this paper, we quantify for the first time such systematic evidence of statistical differences in data recorded during offline and online sessions. Furthermore, we propose novel techniques of investigating and visualizing data distributions, which are particularly useful for the analysis of (non-) stationarities. Our study shows that the brain signals used for control can change substantially from the offline calibration sessions to online control, and also within a single session. In addition to this general characterization of the signals, we propose several adaptive classification schemes and study their performance on data recorded during online experiments. An encouraging result of our study is that surprisingly simple adaptive methods in combination with an offline feature selection scheme can significantly increase BCI performance}, language = {en} } @article{MullerRatschSonnenburgetal.2005, author = {Muller, K. R. and Ratsch, G. and Sonnenburg, S. and Mika, Sebastian and Grimm, M. and Heinrich, N.}, title = {Classifying 'drug-likeness' with kernel-based learning methods}, issn = {1549-9596}, year = {2005}, abstract = {In this article we report about a successful application of modern machine learning technology, namely Support Vector Machines, to the problem of assessing the 'drug-likeness' of a chemical from a given set of descriptors of the Substance. We were able to drastically improve the recent result by Byvatov et al. (2003) on this task and achieved an error rate of about 7\% on unseen compounds using Support Vector Machines. We see a very high potential of such machine learning techniques for a variety of computational chemistry problems that occur in the drug discovery and drug design process}, language = {en} }