@article{LiuHerzschuhWangetal.2014,
  author    = {Liu, Xingqi and Herzschuh, Ulrike and Wang, Yongbo and Kuhn, Gerhard and Yu, Zhitong},
  title     = {Glacier fluctuations of Muztagh Ata and temperature changes during the late Holocene in westernmost Tibetan Plateau, based on glaciolacustrine sediment records},
  series = {Geophysical research letters},
  volume    = {41},
  journal   = {Geophysical research letters},
  number    = {17},
  publisher = {American Geophysical Union},
  address   = {Washington},
  issn      = {0094-8276},
  doi       = {10.1002/2014GL060444},
  pages     = {6265 -- 6273},
  year      = {2014},
  abstract  = {Late Holocene glacier variations in westernmost Tibetan Plateau were studied based on the analysis of grain size, magnetic susceptibility, and elements from an 8.3m long distal glaciolacustrine sediment core of Kalakuli Lake. Our results show that there are four glacier expansion episodes occurring in 4200-3700calibrated years (cal years) B.P., 2950-2300cal years B.P., 1700-1070cal years B.P., and 570-100cal years B.P. and four glacier retreat periods of 3700-2950cal years B.P., 2300-1700cal years B.P., 1070-570cal years B.P., and 50cal years B.P.-present. The four glacier expansion episodes are generally in agreement with the glacier activities indicted by the moraines at Muztagh Ata and Kongur Shan, as well as with the late Holocene ice-rafting events in the North Atlantic. Over the last 2000years, our reconstructed glacier variations are in temporal agreement with reconstructed temperature from China and the Northern Hemisphere, indicating that glacier variations at centennial time scales are very sensitive to temperature in western Tibetan Plateau.},
  language  = {en}
}
@article{RamischLockotHaberzettletal.2016,
  author    = {Ramisch, Arne and Lockot, Gregori and Haberzettl, Torsten and Hartmann, Kai and Kuhn, Gerhard and Lehmkuhl, Frank and Schimpf, Stefan and Schulte, Philipp and Stauch, Georg and Wang, Rong and Wunnemann, Bernd and Yan, Dada and Zhang, Yongzhan and Diekmann, Bernhard},
  title     = {A persistent northern boundary of Indian Summer Monsoon precipitation over Central Asia during the Holocene},
  series = {Scientific reports},
  volume    = {6},
  journal   = {Scientific reports},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/srep25791},
  pages     = {596 -- 633},
  year      = {2016},
  abstract  = {Extra-tropical circulation systems impede poleward moisture advection by the Indian Summer Monsoon. In this context, the Himalayan range is believed to insulate the south Asian circulation from extra-tropical influences and to delineate the northern extent of the Indian Summer Monsoon in central Asia. Paleoclimatic evidence, however, suggests increased moisture availability in the Early Holocene north of the Himalayan range which is attributed to an intensification of the Indian Summer Monsoon. Nevertheless, mechanisms leading to a surpassing of the Himalayan range and the northern maximum extent of summer monsoonal influence remain unknown. Here we show that the Kunlun barrier on the northern Tibetan Plateau [similar to 36 degrees N] delimits Indian Summer Monsoon precipitation during the Holocene. The presence of the barrier relocates the insulation effect 1,000 km further north, allowing a continental low intensity branch of the Indian Summer Monsoon which is persistent throughout the Holocene. Precipitation intensities at its northern extent seem to be driven by differentiated solar heating of the Northern Hemisphere indicating dependency on energy-gradients rather than absolute radiation intensities. The identified spatial constraints of monsoonal precipitation will facilitate the prediction of future monsoonal precipitation patterns in Central Asia under varying climatic conditions.},
  language  = {en}
}
@misc{SchaeferKakularamReischetal.2022,
  author    = {Sch{\"a}fer, Marj{\"a}nn Helena and Kakularam, Kumar Reddy and Reisch, Florian and Rothe, Michael and Stehling, Sabine and Heydeck, Dagmar and P{\"u}schel, Gerhard Paul and Kuhn, Hartmut},
  title     = {Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {1295},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-57649},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-576491},
  pages     = {22},
  year      = {2022},
  abstract  = {Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in cell differentiation and in the pathogenesis of inflammation. The mouse genome involves seven functional Alox genes and the encoded enzymes share a high degree of amino acid conservation with their human orthologs. There are, however, functional differences between mouse and human ALOX orthologs. Human ALOX15B oxygenates arachidonic acid exclusively to its 15-hydroperoxy derivative (15S-HpETE), whereas 8S-HpETE is dominantly formed by mouse Alox15b. The structural basis for this functional difference has been explored and in vitro mutagenesis humanized the reaction specificity of the mouse enzyme. To explore whether this mutagenesis strategy may also humanize the reaction specificity of mouse Alox15b in vivo, we created Alox15b knock-in mice expressing the arachidonic acid 15-lipoxygenating Tyr603Asp+His604Val double mutant instead of the 8-lipoxygenating wildtype enzyme. These mice are fertile, display slightly modified plasma oxylipidomes and develop normally up to an age of 24 weeks. At later developmental stages, male Alox15b-KI mice gain significantly less body weight than outbred wildtype controls, but this effect was not observed for female individuals. To explore the possible reasons for the observed gender-specific growth arrest, we determined the basic hematological parameters and found that aged male Alox15b-KI mice exhibited significantly attenuated red blood cell parameters (erythrocyte counts, hematocrit, hemoglobin). Here again, these differences were not observed in female individuals. These data suggest that humanization of the reaction specificity of mouse Alox15b impairs the functionality of the hematopoietic system in males, which is paralleled by a premature growth arrest.},
  language  = {en}
}
@article{SchaeferKakularamReischetal.2022,
  author    = {Sch{\"a}fer, Marj{\"a}nn Helena and Kakularam, Kumar Reddy and Reisch, Florian and Rothe, Michael and Stehling, Sabine and Heydeck, Dagmar and P{\"u}schel, Gerhard Paul and Kuhn, Hartmut},
  title     = {Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging},
  series = {Biomedicines},
  volume    = {10},
  journal   = {Biomedicines},
  edition   = {6},
  publisher = {MDPI},
  address   = {Basel, Schweiz},
  issn      = {2227-9059},
  doi       = {10.3390/biomedicines10061379},
  pages     = {1 -- 22},
  year      = {2022},
  abstract  = {Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in cell differentiation and in the pathogenesis of inflammation. The mouse genome involves seven functional Alox genes and the encoded enzymes share a high degree of amino acid conservation with their human orthologs. There are, however, functional differences between mouse and human ALOX orthologs. Human ALOX15B oxygenates arachidonic acid exclusively to its 15-hydroperoxy derivative (15S-HpETE), whereas 8S-HpETE is dominantly formed by mouse Alox15b. The structural basis for this functional difference has been explored and in vitro mutagenesis humanized the reaction specificity of the mouse enzyme. To explore whether this mutagenesis strategy may also humanize the reaction specificity of mouse Alox15b in vivo, we created Alox15b knock-in mice expressing the arachidonic acid 15-lipoxygenating Tyr603Asp+His604Val double mutant instead of the 8-lipoxygenating wildtype enzyme. These mice are fertile, display slightly modified plasma oxylipidomes and develop normally up to an age of 24 weeks. At later developmental stages, male Alox15b-KI mice gain significantly less body weight than outbred wildtype controls, but this effect was not observed for female individuals. To explore the possible reasons for the observed gender-specific growth arrest, we determined the basic hematological parameters and found that aged male Alox15b-KI mice exhibited significantly attenuated red blood cell parameters (erythrocyte counts, hematocrit, hemoglobin). Here again, these differences were not observed in female individuals. These data suggest that humanization of the reaction specificity of mouse Alox15b impairs the functionality of the hematopoietic system in males, which is paralleled by a premature growth arrest.},
  language  = {en}
}
@article{HeineckeMischkeAdleretal.2017,
  author    = {Heinecke, Liv and Mischke, Steffen and Adler, Karsten and Barth, Anja and Biskaborn, Boris and Plessen, Birgit and Nitze, Ingmar and Kuhn, Gerhard and Rajabov, Ilhomjon and Herzschuh, Ulrike},
  title     = {Climatic and limnological changes at Lake Karakul (Tajikistan) during the last similar to 29 cal ka},
  series = {Journal of paleolimnolog},
  volume    = {58},
  journal   = {Journal of paleolimnolog},
  publisher = {Springer},
  address   = {Dordrecht},
  issn      = {0921-2728},
  doi       = {10.1007/s10933-017-9980-0},
  pages     = {317 -- 334},
  year      = {2017},
  abstract  = {We present results of analyses on a sediment core from Lake Karakul, located in the eastern Pamir Mountains, Tajikistan. The core spans the last similar to 29 cal ka. We investigated and assessed processes internal and external to the lake to infer changes in past moisture availability. Among the variables used to infer lake-external processes, high values of grain-size end-member (EM) 3 (wide grain-size distribution that reflects fluvial input) and high Sr/Rb and Zr/Rb ratios (coinciding with coarse grain sizes), are indicative of moister conditions. High values in EM1, EM2 (peaks of small grain sizes that reflect long-distance dust transport or fine, glacially derived clastic input) and TiO2 (terrigenous input) are thought to reflect greater influence of dry air masses, most likely of Westerly origin. High input of dust from distant sources, beginning before the Last Glacial Maximum (LGM) and continuing to the late glacial, reflects the influence of dry Westerlies, whereas peaks in fluvial input suggest increased moisture availability. The early to early-middle Holocene is characterised by coarse mean grain sizes, indicating constant, high fluvial input and moister conditions in the region. A steady increase in terrigenous dust and a decrease in fluvial input from 6.6 cal ka BP onwards points to the Westerlies as the predominant atmospheric circulation through to present, and marks a return to drier and even arid conditions in the area. Proxies for productivity (TOC, TOC/TN, TOCBr), redox potential (Fe/Mn) and changes in the endogenic carbonate precipitation (TIC, delta(18) OCarb) indicate changes within the lake. Low productivity characterised the lake from the late Pleistocene until 6.6 cal ka BP, and increased rapidly afterwards. Lake level remained low until the LGM, but water depth increased to a maximum during the late glacial and remained high into the early Holocene. Subsequently, the water level decreased to its present stage. Today the lake system is mainly climatically controlled, but the depositional regime is also driven by internal limnogeological processes.},
  language  = {en}
}
@article{HoffBiskabornDirksenetal.2015,
  author    = {Hoff, Ulrike and Biskaborn, Boris and Dirksen, Veronika G. and Dirksen, Oleg and Kuhn, Gerhard and Meyer, Hanno and Nazarova, Larisa B. and Roth, Alexandra and Diekmann, Bernhard},
  title     = {Holocene environment of Central Kamchatka, Russia: Implications from a multi-proxy record of Two-Yurts Lake},
  series = {Global and planetary change},
  volume    = {134},
  journal   = {Global and planetary change},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0921-8181},
  doi       = {10.1016/j.gloplacha.2015.07.011},
  pages     = {101 -- 117},
  year      = {2015},
  abstract  = {Within the scope of Russian German palaeoenvironmental research, Two-Yurts Lake (TYL, Dvuh-Yurtochnoe in Russian) was chosen as the main scientific target area to decipher Holocene climate variability on Kamchatka. The 5 x 2 km large and 26 m deep lake is of proglacial origin and situated on the eastern flank of Sredinny Ridge at the northwestern end of the Central Kamchatka Valley, outside the direct influence of active volcanism. Here, we present results of a multi-proxy study on sediment cores, spanning about the last 7000 years. The general tenor of the TYL record is an increase in continentality and winter snow cover in conjunction with a decrease in temperature, humidity, and biological productivity after 5000-4500 cal yrs BP, inferred from pollen and diatom data and the isotopic composition of organic carbon. The TYL proxy data also show that the late Holocene was punctuated by two colder spells, roughly between 4500 and 3500 cal yrs BP and between 1000 and 200 cal yrs BP, as local expressions of the Neoglacial and Little Ice Age, respectively. These environmental changes can be regarded as direct and indirect responses to climate change, as also demonstrated by other records in the regional terrestrial and marine realm. Long-term climate deterioration was driven by decreasing insolation, while the short-term climate excursions are best explained by local climatic processes. The latter affect the configuration of atmospheric pressure systems that control the sources as well as the temperature and moisture of air masses reaching Kamchatka. (C) 2015 Elsevier B.V. All rights reserved.},
  language  = {en}
}