@unpublished{AcharyaActisAghajanietal.2013, author = {Acharya, B. S. and Actis, M. and Aghajani, T. and Agnetta, G. and Aguilar, J. and Aharonian, Felix A. and Ajello, M. and Akhperjanian, A. G. and Alcubierre, M. and Aleksic, J. and Alfaro, R. and Aliu, E. and Allafort, A. J. and Allan, D. and Allekotte, I. and Amato, E. and Anderson, J. and Ang{\"u}ner, Ekrem Oǧuzhan and Antonelli, L. A. and Antoranz, P. and Aravantinos, A. and Arlen, T. and Armstrong, T. and Arnaldi, H. and Arrabito, L. and Asano, K. and Ashton, T. and Asorey, H. G. and Awane, Y. and Baba, H. and Babic, A. and Baby, N. and Baehr, J. and Bais, A. and Baixeras, C. and Bajtlik, S. and Balbo, M. and Balis, D. and Balkowski, C. and Bamba, A. and Bandiera, R. and Barber, A. and Barbier, C. and Barcelo, M. and Barnacka, Anna and Barnstedt, J{\"u}rgen and Barres de Almeida, U. and Barrio, J. A. and Basili, A. and Basso, S. and Bastieri, D. and Bauer, C. and Baushev, Anton N. and Becerra Gonzalez, J. and Becherini, Yvonne and Bechtol, K. C. and Tjus, J. Becker and Beckmann, Volker and Bednarek, W. and Behera, B. and Belluso, M. and Benbow, W. and Berdugo, J. and Berger, K. and Bernard, F. and Bernardino, T. and Bernl{\"o}hr, K. and Bhat, N. and Bhattacharyya, S. and Bigongiari, C. and Biland, A. and Billotta, S. and Bird, T. and Birsin, E. and Bissaldi, E. and Biteau, Jonathan and Bitossi, M. and Blake, S. and Blanch Bigas, O. and Blasi, P. and Bobkov, A. A. and Boccone, V. and Boettcher, Markus and Bogacz, L. and Bogart, J. and Bogdan, M. and Boisson, Catherine and Boix Gargallo, J. and Bolmont, J. and Bonanno, G. and Bonardi, A. and Bonev, T. and Bonifacio, P. and Bonnoli, G. and Bordas, Pol and Borgland, A. W. and Borkowski, Janett and Bose, R. and Botner, O. and Bottani, A. and Bouchet, L. and Bourgeat, M. and Boutonnet, C. and Bouvier, A. and Brau-Nogue, S. and Braun, I. and Bretz, T. and Briggs, M. S. and Bringmann, T. and Brook, P. and Brun, Pierre and Brunetti, L. and Buanes, T. and Buckley, J. H. and Buehler, R. and Bugaev, V. and Bulgarelli, A. and Bulik, Tomasz and Busetto, G. and Buson, S. and Byrum, K. and Cailles, M. and Cameron, R. A. and Camprecios, J. and Canestrari, R. and Cantu, S. and Capalbi, M. and Caraveo, P. A. and Carmona, E. and Carosi, A. and Carr, John and Carton, P. H. and Casanova, Sabrina and Casiraghi, M. and Catalano, O. and Cavazzani, S. and Cazaux, S. and Cerruti, M. and Chabanne, E. and Chadwick, Paula M. and Champion, C. and Chen, Andrew and Chiang, J. and Chiappetti, L. and Chikawa, M. and Chitnis, V. R. and Chollet, F. and Chudoba, J. and Cieslar, M. and Cillis, A. N. and Cohen-Tanugi, J. and Colafrancesco, Sergio and Colin, P. and Calome, J. and Colonges, S. and Compin, M. and Conconi, P. and Conforti, V. and Connaughton, V. and Conrad, Jan and Contreras, J. L. and Coppi, P. and Corona, P. and Corti, D. and Cortina, J. and Cossio, L. and Costantini, H. and Cotter, G. and Courty, B. and Couturier, S. and Covino, S. and Crimi, G. and Criswell, S. J. and Croston, J. and Cusumano, G. and Dafonseca, M. and Dale, O. and Daniel, M. and Darling, J. and Davids, I. and Dazzi, F. and De Angelis, A. and De Caprio, V. and De Frondat, F. and de Gouveia Dal Pino, E. M. and de la Calle, I. and De La Vega, G. A. and Lopez, R. de los Reyes and De Lotto, B. and De Luca, A. and de Mello Neto, J. R. T. and de Naurois, M. and de Oliveira, Y. and de Ona Wilhelmi, E. and de Souza, V. and Decerprit, G. and Decock, G. and Deil, C. and Delagnes, E. and Deleglise, G. and Delgado, C. and Della Volpe, D. and Demange, P. and Depaola, G. and Dettlaff, A. and Di Paola, A. and Di Pierro, F. and Diaz, C. and Dick, J. and Dickherber, R. and Dickinson, H. and Diez-Blanco, V. and Digel, S. and Dimitrov, D. and Disset, G. and Djannati-Ata{\"i}, A. and Doert, M. and Dohmke, M. and Domainko, W. and Prester, Dijana Dominis and Donat, A. and Dorner, D. and Doro, M. and Dournaux, J-L. and Drake, G. and Dravins, D. and Drury, L. and Dubois, F. and Dubois, R. and Dubus, G. and Dufour, C. and Dumas, D. and Dumm, J. and Durand, D. and Dyks, J. and Dyrda, M. and Ebr, J. and Edy, E. and Egberts, Kathrin and Eger, P. and Einecke, S. and Eleftheriadis, C. and Elles, S. and Emmanoulopoulos, D. and Engelhaupt, D. and Enomoto, R. and Ernenwein, J-P and Errando, M. and Etchegoyen, A. and Evans, P. and Falcone, A. and Fantinel, D. and Farakos, K. and Farnier, C. and Fasola, G. and Favill, B. and Fede, E. and Federici, S. and Fegan, S. and Feinstein, F. and Ferenc, D. and Ferrando, P. and Fesquet, M. and Fiasson, A. and Fillin-Martino, E. and Fink, D. and Finley, C. and Finley, J. 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F. and Vallania, P. and Vallejo, G. and van Driel, W. and van Eldik, C. and Vandenbrouke, J. and Vanderwalt, J. and Vankov, H. and Vasileiadis, G. and Vassiliev, V. and Veberic, D. and Vegas, I. and Vercellone, S. and Vergani, S. and Veyssiere, C. and Vialle, J. P. and Viana, A. and Videla, M. and Vincent, P. and Vincent, S. and Vink, J. and Vlahakis, N. and Vlahos, L. and Vogler, P. and Vollhardt, A. and von Gunten, H. P. and Vorobiov, S. and Vuerli, C. and Waegebaert, V. and Wagner, R. and Wagner, R. G. and Wagner, S. and Wakely, S. P. and Walter, R. and Walther, T. and Warda, K. and Warwick, R. and Wawer, P. and Wawrzaszek, R. and Webb, N. and Wegner, P. and Weinstein, A. and Weitzel, Q. and Welsing, R. and Werner, M. and Wetteskind, H. and White, R. and Wierzcholska, A. and Wiesand, S. and Wilkinson, M. and Williams, D. A. and Willingale, R. and Winiarski, K. and Wischnewski, R. and Wisniewski, L. and Wood, M. and Woernlein, A. and Xiong, Q. and Yadav, K. K. and Yamamoto, H. and Yamamoto, T. and Yamazaki, R. and Yanagita, S. and Yebras, J. M. and Yelos, D. and Yoshida, A. and Yoshida, T. and Yoshikoshi, T. and Zabalza, V. and Zacharias, M. and Zajczyk, A. and Zanin, R. and Zdziarski, A. and Zech, Alraune and Zhao, A. and Zhou, X. and Zietara, K. and Ziolkowski, J. and Ziolkowski, P. and Zitelli, V. and Zurbach, C. and Zychowski, P.}, title = {Introducing the CTA concept}, series = {Astroparticle physics}, volume = {43}, journal = {Astroparticle physics}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, organization = {CTA Consortium}, issn = {0927-6505}, doi = {10.1016/j.astropartphys.2013.01.007}, pages = {3 -- 18}, year = {2013}, abstract = {The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project.}, language = {en} } @article{SramaAhrensAltobellietal.2004, author = {Srama, Ralf and Ahrens, Thomas J. and Altobelli, Nicolas and Auer, S. and Bradley, J. G. and Burton, M. and Dikarev, V. V. and Economou, T. and Fechtig, Hugo and G{\"o}rlich, M. and Grande, M. and Graps, Amara and Gr{\"u}n, Eberhard and Havnes, Ove and Helfert, Stefan and Horanyi, Mihaly and Igenbergs, E. and Jessberger, Elmar K. and Johnson, T. V. and Kempf, Sascha and Krivov, Alexander v. and Kr{\"u}ger, Harald and Mocker-Ahlreep, Anna and Moragas-Klostermeyer, Georg and Lamy, Philippe and Landgraf, Markus and Linkert, Dietmar and Linkert, G. and Lura, F. and McDonnell, J. A. M. and Moehlmann, Dirk and Morfill, Gregory E. and Muller, M. and Roy, M. and Schafer, G. and Schlotzhauer, G. and Schwehm, Gerhard H. and Spahn, Frank and St{\"u}big, M. and Svestka, Jiri and Tschernjawski, V}, title = {The Cassini Cosmic Dust Analyzer}, issn = {0038-6308}, year = {2004}, abstract = {The Cassini-Huygens Cosmic Dust Analyzer (CDA) is intended to provide direct observations of dust grains with masses between 10(-19) and 10(-9) kg in interplanetary space and in the jovian and saturnian systems, to investigate their physical, chemical and dynamical properties as functions of the distances to the Sun, to Jupiter and to Saturn and its satellites and rings, to study their interaction with the saturnian rings, satellites and magnetosphere. Chemical composition of interplanetary meteoroids will be compared with asteroidal and cometary dust, as well as with Saturn dust, ejecta from rings and satellites. Ring and satellites phenomena which might be effects of meteoroid impacts will be compared with the interplanetary dust environment. Electrical charges of particulate matter in the magnetosphere and its consequences will be studied, e.g. the effects of the ambient plasma and the magnetic held on the trajectories of dust particles as well as fragmentation of particles due to electrostatic disruption. The investigation will be performed with an instrument that measures the mass, composition, electric charge, speed, and flight direction of individual dust particles. It is a highly reliable and versatile instrument with a mass sensitivity 106 times higher than that of the Pioneer 10 and I I dust detectors which measured dust in the saturnian system. The Cosmic Dust Analyzer has significant inheritance from former space instrumentation developed for the VEGA, Giotto, Galileo, and Ulysses missions. It will reliably measure impacts from as low as I impact per month up to 104 impacts per second. The instrument weighs 17 kg and consumes 12 W, the integrated time-of-flight mass spectrometer has a mass resolution of up to 50. The nominal data transmission rate is 524 bits/s and varies between 50 and 4192 bps}, language = {en} } @article{HocherOberthuerSlowinskietal.2013, author = {Hocher, Berthold and Oberth{\"u}r, Dominik and Slowinski, Torsten and Querfeld, Uwe and Sch{\"a}fer, Franz and Doyon, Anke and Tepel, Martin and Roth, Heinz J. and Gr{\"o}n, Hans J. and Reichetzeder, Christoph and Betzel, Christian and Armbruster, Franz Paul}, title = {Modeling of Oxidized PTH (oxPTH) and Non-oxidized PTH (n-oxPTH) Receptor Binding and Relationship of Oxidized to Non-Oxidized PTH in Children with Chronic Renal Failure, Adult Patients on Hemodialysis and Kidney Transplant Recipients}, series = {Kidney \& blood pressure research : official organ of the Gesellschaft f{\"u}r Nephrologie}, volume = {37}, journal = {Kidney \& blood pressure research : official organ of the Gesellschaft f{\"u}r Nephrologie}, number = {4-5}, publisher = {Karger}, address = {Basel}, issn = {1420-4096}, doi = {10.1159/000350149}, pages = {240 -- 251}, year = {2013}, abstract = {Background: The biological properties of oxidized and non-oxidized PTH are substantially different. Oxidized PTH (oxPTH) loses its PTH receptor-stimulating properties, whereas non-oxidized PTH (n-oxPTH) is a full agonist of the receptor. This was described in more than 20 well published studies in the 1970(s) and 80(s). However, PTH oxidation has been ignored during the development of PTH assays for clinical use so far. Even the nowadays used third generation assay systems do not consider oxidation of PTH. We recently developed an assay to differentiate between oxPTH and n-oxPTH. In the current study we established normal values for this assay system. Furthermore, we compare the ratio of oxPTH to n-oxPTH in different population with chronic renal failure: 620 children with renal failure stage 2-4 of the 4C study, 342 adult patients on dialysis, and 602 kidney transplant recipients. In addition, we performed modeling of the interaction of either oxPTH or n-oxPTH with the PTH receptor using biophysical structure approaches. Results: The children had the highest mean as well as maximum n-oxPTH concentrations as compared to adult patients (both patients on dialysis as well as kidney transplant recipients). The relationship between oxPTH and n-oxPTH of individual patients varied substantially in all three populations with renal impairment. The analysis of n-oxPTH in 89 healthy control subjects revealed that n-oxPTH concentrations in patient with renal failure were higher as compared to healthy adult controls (2.25-fold in children with renal failure, 1.53-fold in adult patients on dialysis, and 1.56-fold in kidney transplant recipients, respectively). Computer assisted biophysical structure modeling demonstrated, however, minor sterical- and/or electrostatic changes in oxPTH and n-oxPTH. This indicated that PTH oxidation may induce refolding of PTH and hence alters PTH-PTH receptor interaction via oxidation induced three-dimensional structure alteration of PTH. Conclusion: A huge proportion of circulating PTH measured by current state-of-the-art assay systems is oxidized and thus not biologically active. The relationship between oxPTH and n-oxPTH of individual patients varied substantially. Non-oxidized PTH concentrations are 1.5 - 2.25 fold higher in patients with renal failure as compared to health controls. Measurements of n-oxPTH may reflect the hormone status more precise. The iPTH measures describes most likely oxidative stress in patients with renal failure rather than the PTH hormone status. This, however, needs to be demonstrated in further clinical studies.}, language = {en} } @article{SengeRosslervonGersdorffetal.2004, author = {Senge, Mathias O. and Rossler, B. and von Gersdorff, J. and Schafer, A. and Kurreck, H.}, title = {The meso-beta-linkage as structural motif in porphyrin-based donor-acceptor compounds}, issn = {0040-4039}, year = {2004}, abstract = {Synthetic strategies for using the beta-linkage as a structural motif in electron transfer mimics have been tested. Exploratory syntheses of directly meso-beta-linked bis- and trisporphyrins and the first representative X-ray structure of a meso-beta-linked bisporphyrins are reported. The structure reveals a unique form of intramolecular- pi-pi stabilization between one porphyrin and a meso-aryl substituent in a second porphyrin unit that accounts for the stability of different atropisomers in trimers. Using beta-formyl porphyrins, dipyrromethanes, and suitable quinone precursor aldehydes, mixed condensations gave convenient access to porphyrin-porphyrin-quinone (P-P-Q) donor acceptor systems consisting of a meso-beta-linked bisporphyrin. a spacer, and a quinone acceptor. (C) 2004 Elsevier Ltd. All rights reserved}, language = {en} } @inproceedings{DoyonSchmiedchenBayazitetal.2012, author = {Doyon, Anke and Schmiedchen, Bettina and Bayazit, Aysun and Canpolat, Nur and Duzova, Ali and Kracht, Daniela and Litwin, Mieczyslaw and Niemirska, Anna and Sozeri, Betul and Zeller, Rene and Anarat, Ali and Caliskan, Salim and Mir, Sevgi and Shroff, Rukshana and Melk, Anette and W{\"u}hl, Elke and Schweigert, Florian J. and Querfeld, Uwe and Sch{\"a}fer, Franz}, title = {Altered arterial morphology and function in children with CKD Role of mineral-bone disorder}, series = {Pediatric nephrology : journal of the International Pediatric Nephrology Association}, volume = {27}, booktitle = {Pediatric nephrology : journal of the International Pediatric Nephrology Association}, number = {9}, publisher = {Springer}, address = {New York}, organization = {4C Study Consortium}, issn = {0931-041X}, pages = {1606 -- 1607}, year = {2012}, language = {en} } @inproceedings{DoyonSchmiedchenBayazitetal.2012, author = {Doyon, Anke and Schmiedchen, Bettina and Bayazit, Aysun and Canpolat, Nur and Duzova, Ali and Kracht, Daniela and Litwin, Mieczyslaw and Niemirska, Anna and Sozeri, Betul and Zeller, Rene and Ranchin, Bruno and Anarat, Ali and Caliskan, Salim and Mir, Sevgi and Melk, Anette and W{\"u}hl, Elke and Schweigert, Florian J. and Querfeld, Uwe and Sch{\"a}fer, Franz}, title = {Distribuion and determinants of serum vitamin d concentrations in european children with chronic kidney disease}, series = {Pediatric nephrology : journal of the International Pediatric Nephrology Association}, volume = {27}, booktitle = {Pediatric nephrology : journal of the International Pediatric Nephrology Association}, number = {9}, publisher = {Springer}, address = {New York}, organization = {4C Consortium}, issn = {0931-041X}, pages = {1627 -- 1628}, year = {2012}, language = {en} }