@article{MorenoMelnickRosenauetal.2012, author = {Moreno, Marcelo Spegiorin and Melnick, Daniel and Rosenau, M. and B{\´a}ez, Juan Carlos and Klotz, Jan and Oncken, Onno and Tassara, Andres and Chen, J. and Bataille, Klaus and Bevis, M. and Socquet, Anne and Bolte, John and Vigny, C. and Brooks, B. and Ryder, I. and Grund, Volker and Smalley, B. and Carrizo, Daniel and Bartsch, M. and Hase, H.}, title = {Toward understanding tectonic control on the M-w 8.8 2010 Maule Chile earthquake}, series = {Earth \& planetary science letters}, volume = {321}, journal = {Earth \& planetary science letters}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0012-821X}, doi = {10.1016/j.epsl.2012.01.006}, pages = {152 -- 165}, year = {2012}, abstract = {The Maule earthquake of 27th February 2010 (M-w = 8.8) affected similar to 500 km of the Nazca-South America plate boundary in south-central Chile producing spectacular crustal deformation. Here, we present a detailed estimate of static coseismic surface offsets as measured by survey and continuous GPS, both in near- and far-field regions. Earthquake slip along the megathrust has been inferred from a Joint inversion of our new data together with published GPS, InSAR, and land-level changes data using Green's functions generated by a spherical finite-element model with realistic subduction zone geometry. The combination of the data sets provided a good resolution, indicating that most of the slip was well resolved. Coseismic slip was concentrated north of the epicenter with up to 16 m of slip, whereas to the south it reached over 10 m within two minor patches. A comparison of coseismic slip with the slip deficit accumulated since the last great earthquake in 1835 suggests that the 2010 event closed a mature seismic gap. Slip deficit distribution shows an apparent local overshoot that highlight cycle-to-cycle variability, which has to be taken into account when anticipating future events from interseismic observations. Rupture propagation was obviously not affected by bathymetric features of the incoming plate. Instead, splay faults in the upper plate seem to have limited rupture propagation in the updip and along-strike directions. Additionally, we found that along-strike gradients in slip are spatially correlated with geometrical inflections of the megathrust. Our study suggests that persistent tectonic features may control strain accumulation and release along subduction megathrusts.}, language = {en} } @article{MorenoMelnickRosenauetal.2011, author = {Moreno, Marcelo Spegiorin and Melnick, Daniel and Rosenau, M. and Bolte, John and Klotz, Jan and Echtler, Helmut Peter and B{\´a}ez, Juan Carlos and Bataille, Klaus and Chen, J. and Bevis, M. and Hase, H. and Oncken, Onno}, title = {Heterogeneous plate locking in the South-Central Chile subduction zone building up the next great earthquake}, series = {Earth \& planetary science letters}, volume = {305}, journal = {Earth \& planetary science letters}, number = {3-4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0012-821X}, doi = {10.1016/j.epsl.2011.03.025}, pages = {413 -- 424}, year = {2011}, abstract = {We use Global Positioning System (GPS) velocities and kinematic Finite Element models (FE-models) to infer the state of locking between the converging Nazca and South America plates in South-Central Chile (36 degrees S -46 degrees S) and to evaluate its spatial and temporal variability. GPS velocities provide information on earthquake-cycle deformation over the last decade in areas affected by the megathrust events of 1960 (M-w = 9.5) and 2010 (M-w = 8.8). Our data confirm that a change in surface velocity patterns of these two seismotectonic segments can be related to their different stages in the seismic cycle: Accordingly, the northern (2010) segment was in a final stage of interseismic loading whereas the southern (1960) segment is still in a postseismic stage and undergoes a prolonged viscoelastic mantle relaxation. After correcting the signals for mantle relaxation, the residual GPS velocity pattern suggests that the plate interface accumulates slip deficit in a spatially and presumably temporally variable way towards the next great event. Though some similarity exist between locking and 1960 coseismic slip, extrapolating the current, decadal scale slip deficit accumulation towards the similar to 300-yr recurrence times of giant events here does neither yield the slip distribution nor the moment magnitude of the 1960 earthquake. This suggests that either the locking pattern is evolving in time (to reconcile a slip deficit distribution similar to the 1960 earthquake) or that some asperities are not persistent over multiple events. The accumulated moment deficit since 1960 suggests that highly locked patches in the 1960 segment are already capable of producing a M similar to 8 event if triggered to fail by stress transfer from the 2010 event.}, language = {en} } @article{LangeBedfordMorenoetal.2014, author = {Lange, Dietrich and Bedford, J. R. and Moreno, M. and Tilmann, F. and B{\´a}ez, Juan Carlos and Bevis, M. and Kr{\"u}ger, Frank}, title = {Comparison of postseismic afterslip models with aftershock seismicity for three subduction-zone earthquakes: Nias 2005, Maule 2010 and Tohoku 2011}, series = {Geophysical journal international}, volume = {199}, journal = {Geophysical journal international}, number = {2}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0956-540X}, doi = {10.1093/gji/ggu292}, pages = {784 -- 799}, year = {2014}, abstract = {We focus on the relation between seismic and total postseismic afterslip following the Maule M-w 8.8 earthquake on 2010 February 27 in central Chile. First, we calculate the cumulative slip released by aftershock seismicity. We do this by summing up the aftershock regions and slip estimated from scaling relations. Comparing the cumulative seismic slip with afterslip modelswe showthat seismic slip of individual aftershocks exceeds locally the inverted afterslip model from geodetic constraints. As the afterslip model implicitly contains the displacements from the aftershocks, this reflects the tendency of afterslip models to smear out the actual slip pattern. However, it also suggests that locally slip for a number of the larger aftershocks exceeds the aseismic slip in spite of the fact that the total equivalent moment of the afterslip exceeds the cumulative moment of aftershocks by a large factor. This effect, seen weakly for the Maule 2010 and also for the Tohoku 2011 earthquake, can be explained by taking into account the uncertainties of the seismicity and afterslip models. In spite of uncertainties, the hypocentral region of the Nias 2005 earthquake is suggested to release a large fraction of moment almost purely seismically. Therefore, these aftershocks are not driven solely by the afterslip but instead their slip areas have probably been stressed by interseismic loading and the mainshock rupture. In a second step, we divide the megathrust of the Maule 2010 rupture into discrete cells and count the number of aftershocks that occur within 50 km of the centre of each cell as a function of time. We then compare this number to a time-dependent afterslip model by defining the 'afterslip to aftershock ratio' (ASAR) for each cell as the slope of the best fitting line when the afterslip at time t is plotted against aftershock count. Although we find a linear relation between afterslip and aftershocks for most cells, there is significant variability in ASAR in both the downdip and along-strike directions of the megathrust. We compare the spatial distribution of ASAR with the spatial distribution of seismic coupling, coseismic slip and Bouguer gravity anomaly, and in each case we find no significant correlation.}, language = {en} } @article{HenryNeillBeckeretal.2015, author = {Henry, Brian D. and Neill, Daniel R. and Becker, Katrin Anne and Gore, Suzanna and Bricio-Moreno, Laura and Ziobro, Regan and Edwards, Michael J. and Muehlemann, Kathrin and Steinmann, Joerg and Kleuser, Burkhard and Japtok, Lukasz and Luginbuehl, Miriam and Wolfmeier, Heidi and Scherag, Andre and Gulbins, Erich and Kadioglu, Aras and Draeger, Annette and Babiychuk, Eduard B.}, title = {Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice}, series = {Nature biotechnology : the science and business of biotechnology}, volume = {33}, journal = {Nature biotechnology : the science and business of biotechnology}, number = {1}, publisher = {Nature Publ. Group}, address = {New York}, issn = {1087-0156}, doi = {10.1038/nbt.3037}, pages = {81 -- U295}, year = {2015}, abstract = {Gram-positive bacterial pathogens that secrete cytotoxic pore-forming toxins, such as Staphylococcus aureus and Streptococcus pneumoniae, cause a substantial burden of disease. Inspired by the principles that govern natural toxin-host interactions, we have engineered artificial liposomes that are tailored to effectively compete with host cells for toxin binding. Liposome-bound toxins are unable to lyse mammalian cells in vitro. We use these artificial liposomes as decoy targets to sequester bacterial toxins that are produced during active infection in vivo. Administration of artificial liposomes within 10 h after infection rescues mice from septicemia caused by S. aureus and S. pneumoniae, whereas untreated mice die within 24-33 h. Furthermore, liposomes protect mice against invasive pneumococcal pneumonia. Composed exclusively of naturally occurring lipids, tailored liposomes are not bactericidal and could be used therapeutically either alone or in conjunction with antibiotics to combat bacterial infections and to minimize toxin-induced tissue damage that occurs during bacterial clearance.}, language = {en} } @misc{ZorHeiskanenCavigliaetal.2014, author = {Z{\´o}r, K. and Heiskanen, A. and Caviglia, Claudia and Vergani, M. and Landini, E. and Shah, F. and Carminati, Marco and Mart{\´i}nez-Serrano, A. and Ramos Moreno, T. and Kokaia, M. and Benayahu, Dafna and Keresztes, Zs. and Papkovsky, D. and Wollenberger, Ursula and Svendsen, W. E. and Dimaki, M. and Ferrari, G. and Raiteri, R. and Sampietro, M. and Dufva, M. and Emn{\´e}us, J.}, title = {A compact multifunctional microfluidic platform for exploring cellular dynamics in real-time using electrochemical detection}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-99492}, pages = {11}, year = {2014}, abstract = {Downscaling of microfluidic cell culture and detection devices for electrochemical monitoring has mostly focused on miniaturization of the microfluidic chips which are often designed for specific applications and therefore lack functional flexibility. We present a compact microfluidic cell culture and electrochemical analysis platform with in-built fluid handling and detection, enabling complete cell based assays comprising on-line electrode cleaning, sterilization, surface functionalization, cell seeding, cultivation and electrochemical real-time monitoring of cellular dynamics. To demonstrate the versatility and multifunctionality of the platform, we explored amperometric monitoring of intracellular redox activity in yeast (Saccharomyces cerevisiae) and detection of exocytotically released dopamine from rat pheochromocytoma cells (PC12). Electrochemical impedance spectroscopy was used in both applications for monitoring cell sedimentation and adhesion as well as proliferation in the case of PC12 cells. The influence of flow rate on the signal amplitude in the detection of redox metabolism as well as the effect of mechanical stimulation on dopamine release were demonstrated using the programmable fluid handling capability. The here presented platform is aimed at applications utilizing cell based assays, ranging from e.g. monitoring of drug effects in pharmacological studies, characterization of neural stem cell differentiation, and screening of genetically modified microorganisms to environmental monitoring.}, language = {en} } @article{NietoMorenoRohrmannvanderMeeretal.2016, author = {Nieto-Moreno, Vanesa and Rohrmann, Alexander and van der Meer, Marcel T. J. and Damste, Jaap S. Sinninghe and Sachse, Dirk and Tofelde, Stefanie and Niedermeyer, Eva M. and Strecker, Manfred and Mulch, Andreas}, title = {Elevation-dependent changes in n-alkane delta D and soil GDGTs across the South Central Andes}, series = {Earth \& planetary science letters}, volume = {453}, journal = {Earth \& planetary science letters}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0012-821X}, doi = {10.1016/j.epsl.2016.07.049}, pages = {234 -- 242}, year = {2016}, abstract = {Surface uplift of large plateaus may significantly influence regional climate and more specifically precipitation patterns and temperature, sometimes complicating paleoaltimetry interpretations. Thus, understanding the topographic evolution of tectonically active mountain belts benefits from continued development of reliable proxies to reduce uncertainties in paleoaltimetry reconstructions. Lipid biomarker-based proxies provide a novel approach to stable isotope paleoaltimetry and complement authigenic or pedogenic mineral proxy materials, in particular outside semi-arid climate zones where soil carbonates are not abundant but (soil) organic matter has a high preservation potential. Here we present delta D values of soil-derived n-alkanes and mean annual air temperature (MAT) estimates based on branched glycerol dialkyl glycerol tetraether (brGDGT) distributions to assess their potential for paleoelevation reconstructions in the southern central Andes. We analyzed soil samples across two environmental and hydrological gradients that include a hillslope (26-28 degrees S) and a valley (22-24 degrees S) transect on the windward flanks of Central Andean Eastern Cordillera in NW Argentina. Our results show that present-day n-alkane delta D values and brGDGT-based MAT estimates are both linearly related with elevation and in good agreement with present-day climate conditions. Soil n-alkanes show a delta D lapse rate (A(delta D)) of -1.64 parts per thousand/100 m (R-2 = 0.91, p < 0.01) at the hillslope transect, within the range of delta D lapse rates from precipitation and surface waters in other tropical regions in the Andes like the Eastern Cordillera in Colombia and Bolivia and the Equatorial and Peruvian Andes. BrGDGT-derived soil temperatures are similar to monitored winter temperatures in the region and show a lapse rate of Delta T = -0.51 degrees C/100 m (R-2 = 0.91, p < 0.01), comparable with lapse rates from in situ soil temperature measurements, satellite derived land-surface temperatures at this transect, and weather stations from the Eastern Cordillera at similar latitude. As a result of an increasing leeward sampling position along the valley transect lapse rates are biased towards lower values and display higher scatter (Delta(delta D) = -0.9 parts per thousand/100 m, R-2 = 0.76, p < 0.01 and Delta T = -0.19 degrees C/100 m, R-2 = 0.48, p < 0.05). Despite this higher complexity, they are in line with lapse rates from stream-water samples and in situ soil temperature measurements along the same transect. Our results demonstrate that both soil n-alkane delta D values and MAT reconstructions based on brGDGTs distributions from the hillslope transect (Delta(delta D) = -1.64 parts per thousand/100 m, R-2 = 0.91, p < 0.01 and Delta T = -0.51 degrees C/100 m, R-2 = 0.91, p < 0.01) track the direct effects of orography on precipitation and temperature and hence the combined effects of local and regional hydrology as well as elevation. (C) 2016 Elsevier B.V. All rights reserved.}, language = {en} } @article{TilmannZhangMorenoetal.2016, author = {Tilmann, F. and Zhang, Y. and Moreno, M. and Saul, J. and Eckelmann, F. and Palo, M. and Deng, Z. and Babeyko, Andrey and Chen, K. and B{\´a}ez, Juan Carlos and Schurr, B. and Wang, R. and Dahm, Torsten}, title = {The 2015 Illapel earthquake, central Chile: A type case for a characteristic earthquake?}, series = {Geophysical research letters}, volume = {43}, journal = {Geophysical research letters}, publisher = {American Geophysical Union}, address = {Washington}, issn = {0094-8276}, doi = {10.1002/2015GL066963}, pages = {574 -- 583}, year = {2016}, abstract = {On 16 September 2015, the M-W = 8.2 Illapel megathrust earthquake ruptured the Central Chilean margin. Combining inversions of displacement measurements and seismic waveforms with high frequency (HF) teleseismic backprojection, we derive a comprehensive description of the rupture, which also predicts deep ocean tsunami wave heights. We further determine moment tensors and obtain accurate depth estimates for the aftershock sequence. The earthquake nucleated near the coast but then propagated to the north and updip, attaining a peak slip of 5-6 m. In contrast, HF seismic radiation is mostly emitted downdip of the region of intense slip and arrests earlier than the long period rupture, indicating smooth slip along the shallow plate interface in the final phase. A superficially similar earthquake in 1943 with a similar aftershock zone had a much shorter source time function, which matches the duration of HF seismic radiation in the recent event, indicating that the 1943 event lacked the shallow slip.}, language = {en} } @article{MantzoukiCampbellvanLoonetal.2018, author = {Mantzouki, Evanthia and Campbell, James and van Loon, Emiel and Visser, Petra and Konstantinou, Iosif and Antoniou, Maria and Giuliani, Gregory and Machado-Vieira, Danielle and de Oliveira, Alinne Gurjao and Maronic, Dubravka Spoljaric and Stevic, Filip and Pfeiffer, Tanja Zuna and Vucelic, Itana Bokan and Zutinic, Petar and Udovic, Marija Gligora and Plenkovic-Moraj, Andelka and Tsiarta, Nikoletta and Blaha, Ludek and Geris, Rodan and Frankova, Marketa and Christoffersen, Kirsten Seestern and Warming, Trine Perlt and Feldmann, Tonu and Laas, Alo and Panksep, Kristel and Tuvikene, Lea and Kangro, Kersti and Haggqvist, Kerstin and Salmi, Pauliina and Arvola, Lauri and Fastner, Jutta and Straile, Dietmar and Rothhaupt, Karl-Otto and Fonvielle, Jeremy Andre and Grossart, Hans-Peter and Avagianos, Christos and Kaloudis, Triantafyllos and Triantis, Theodoros and Zervou, Sevasti-Kiriaki and Hiskia, Anastasia and Gkelis, Spyros and Panou, Manthos and McCarthy, Valerie and Perello, Victor C. and Obertegger, Ulrike and Boscaini, Adriano and Flaim, Giovanna and Salmaso, Nico and Cerasino, Leonardo and Koreiviene, Judita and Karosiene, Jurate and Kasperoviciene, Jurate and Savadova, Ksenija and Vitonyte, Irma and Haande, Sigrid and Skjelbred, Birger and Grabowska, Magdalena and Karpowicz, Maciej and Chmura, Damian and Nawrocka, Lidia and Kobos, Justyna and Mazur-Marzec, Hanna and Alcaraz-Parraga, Pablo and Wilk-Wozniak, Elzbieta and Krzton, Wojciech and Walusiak, Edward and Gagala, Ilona and Mankiewicz-Boczek, Joana and Toporowska, Magdalena and Pawlik-Skowronska, Barbara and Niedzwiecki, Michal and Peczula, Wojciech and Napiorkowska-Krzebietke, Agnieszka and Dunalska, Julita and Sienska, Justyna and Szymanski, Daniel and Kruk, Marek and Budzynska, Agnieszka and Goldyn, Ryszard and Kozak, Anna and Rosinska, Joanna and Szelag-Wasielewska, Elzbieta and Domek, Piotr and Jakubowska-Krepska, Natalia and Kwasizur, Kinga and Messyasz, Beata and Pelechata, Aleksandra and Pelechaty, Mariusz and Kokocinski, Mikolaj and Madrecka, Beata and Kostrzewska-Szlakowska, Iwona and Frak, Magdalena and Bankowska-Sobczak, Agnieszka and Wasilewicz, Michal and Ochocka, Agnieszka and Pasztaleniec, Agnieszka and Jasser, Iwona and Antao-Geraldes, Ana M. and Leira, Manel and Hernandez, Armand and Vasconcelos, Vitor and Morais, Joao and Vale, Micaela and Raposeiro, Pedro M. and Goncalves, Vitor and Aleksovski, Boris and Krstic, Svetislav and Nemova, Hana and Drastichova, Iveta and Chomova, Lucia and Remec-Rekar, Spela and Elersek, Tina and Delgado-Martin, Jordi and Garcia, David and Luis Cereijo, Jose and Goma, Joan and Carmen Trapote, Mari and Vegas-Vilarrubia, Teresa and Obrador, Biel and Garcia-Murcia, Ana and Real, Monserrat and Romans, Elvira and Noguero-Ribes, Jordi and Parreno Duque, David and Fernandez-Moran, Elisabeth and Ubeda, Barbara and Angel Galvez, Jose and Marce, Rafael and Catalan, Nuria and Perez-Martinez, Carmen and Ramos-Rodriguez, Eloisa and Cillero-Castro, Carmen and Moreno-Ostos, Enrique and Maria Blanco, Jose and Rodriguez, Valeriano and Juan Montes-Perez, Jorge and Palomino, Roberto L. and Rodriguez-Perez, Estela and Carballeira, Rafael and Camacho, Antonio and Picazo, Antonio and Rochera, Carlos and Santamans, Anna C. and Ferriol, Carmen and Romo, Susana and Soria, Juan Miguel and Hansson, Lars-Anders and Urrutia-Cordero, Pablo and Ozen, Arda and Bravo, Andrea G. and Buck, Moritz and Colom-Montero, William and Mustonen, Kristiina and Pierson, Don and Yang, Yang and Verspagen, Jolanda M. H. and Domis, Lisette N. de Senerpont and Seelen, Laura and Teurlincx, Sven and Verstijnen, Yvon and Lurling, Miquel and Maliaka, Valentini and Faassen, Elisabeth J. and Latour, Delphine and Carey, Cayelan C. and Paerl, Hans W. and Torokne, Andrea and Karan, Tunay and Demir, Nilsun and Beklioglu, Meryem and Filiz, Nur and Levi, Eti E. and Iskin, Ugur and Bezirci, Gizem and Tavsanoglu, Ulku Nihan and Celik, Kemal and Ozhan, Koray and Karakaya, Nusret and Kocer, Mehmet Ali Turan and Yilmaz, Mete and Maraslioglu, Faruk and Fakioglu, Ozden and Soylu, Elif Neyran and Yagci, Meral Apaydin and Cinar, Sakir and Capkin, Kadir and Yagci, Abdulkadir and Cesur, Mehmet and Bilgin, Fuat and Bulut, Cafer and Uysal, Rahmi and Koker, Latife and Akcaalan, Reyhan and Albay, Meric and Alp, Mehmet Tahir and Ozkan, Korhan and Sevindik, Tugba Ongun and Tunca, Hatice and Onem, Burcin and Richardson, Jessica and Edwards, Christine and Bergkemper, Victoria and Beirne, Eilish and Cromie, Hannah and Ibelings, Bastiaan W.}, title = {Data Descriptor: A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins}, series = {Scientific Data}, volume = {5}, journal = {Scientific Data}, publisher = {Nature Publ. Group}, address = {London}, issn = {2052-4463}, doi = {10.1038/sdata.2018.226}, pages = {13}, year = {2018}, abstract = {Under ongoing climate change and increasing anthropogenic activity, which continuously challenge ecosystem resilience, an in-depth understanding of ecological processes is urgently needed. Lakes, as providers of numerous ecosystem services, face multiple stressors that threaten their functioning. Harmful cyanobacterial blooms are a persistent problem resulting from nutrient pollution and climate-change induced stressors, like poor transparency, increased water temperature and enhanced stratification. Consistency in data collection and analysis methods is necessary to achieve fully comparable datasets and for statistical validity, avoiding issues linked to disparate data sources. The European Multi Lake Survey (EMLS) in summer 2015 was an initiative among scientists from 27 countries to collect and analyse lake physical, chemical and biological variables in a fully standardized manner. This database includes in-situ lake variables along with nutrient, pigment and cyanotoxin data of 369 lakes in Europe, which were centrally analysed in dedicated laboratories. Publishing the EMLS methods and dataset might inspire similar initiatives to study across large geographic areas that will contribute to better understanding lake responses in a changing environment.}, language = {en} }