@article{ToulouseSchmuckerMeteschetal.2019, author = {Toulouse, Charlotte Marguerite and Schmucker, Sonja and Metesch, Kristina and Pfannstiel, Jens and Michel, Bernd and Starke, Ines and M{\"o}ller, Heiko Michael and Stefanski, Volker and Steuber, Julia}, title = {Mechanism and impact of catecholamine conversion by Vibrio cholerae}, series = {Biochimica et biophysica acta : Bioenergetics}, volume = {1860}, journal = {Biochimica et biophysica acta : Bioenergetics}, number = {6}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0005-2728}, doi = {10.1016/j.bbabio.2019.04.003}, pages = {478 -- 487}, year = {2019}, abstract = {Bacterial pathogens are influenced by signaling molecules including the catecholamines adrenaline and noradrenaline which are host-derived hormones and neurotransmitters. Adrenaline and noradrenaline modulate growth, motility and virulence of bacteria. We show that adrenaline is converted by the pathogen Vibrio cholerae to adrenochrome in the course of respiration, and demonstrate that superoxide produced by the respiratory, Na+ - translocating NADH:quinone oxidoreductase (NQR) acts as electron acceptor in the oxidative conversion of adrenaline to adrenochrome. Adrenochrome stimulates growth of V. cholerae, and triggers specific responses in V. cholerae and in immune cells. We performed a quantitative proteome analysis of V. cholerae grown in minimal medium with glucose as carbon source without catecholamines, or with adrenaline, noradrenaline or adrenochrome. Significant regulation of proteins participating in iron transport and iron homeostasis, in energy metabolism, and in signaling was observed upon exposure to adrenaline, noradrenaline or adrenochrome. On the host side, adrenochrome inhibited lipopolysaccharide-triggered formation of TNF-alpha by THP-1 monocytes, though to a lesser extent than adrenaline. It is proposed that adrenochrome produced from adrenaline by respiring V. cholerae functions as effector molecule in pathogen-host interaction.}, language = {en} } @article{ShainyanMoskalikStarkeetal.2010, author = {Shainyan, Bagrat A. and Moskalik, Mikail Yu and Starke, Ines and Schilde, Uwe}, title = {Formation of unexpected products in the attempted aziridination of styrene with trifluoromethanesulfonyl nitrene}, issn = {0040-4020}, doi = {10.1016/j.tet.2010.08.070}, year = {2010}, abstract = {The reaction of styrene with trifluoromethanesulfonyl nitrene generated from trifluoromethanesulfonamide in the system (t-BuOCl+NaI) results in the formation of trifluoro-N-[2-phenyl-2-(trifluoromethylsulfonyl) aminoethyl]methanesulfonamide, 1-pheny1-2-iodo-ethanol, and 2,5-diphenyl-1,4-bis(trifluoromethyl sulfonyl)piperazine rather than the expected product of aziridination, 2-phenyl-1-(trifluoromethylsulfonyl) aziridine. The mechanism of the reaction is discussed.}, language = {en} } @article{StarkeKochKammeretal.2018, author = {Starke, Ines and Koch, Andreas and Kammer, Stefan and Holdt, Hans-J{\"u}rgen and M{\"o}ller, Heiko Michael}, title = {Electrospray mass spectrometry and molecular modeling study of formation and stability of silver complexes with diazaperylene and bisisoquinoline}, series = {Journal of mass spectrometry}, volume = {53}, journal = {Journal of mass spectrometry}, number = {5}, publisher = {Wiley}, address = {Hoboken}, issn = {1076-5174}, doi = {10.1002/jms.4071}, pages = {408 -- 418}, year = {2018}, abstract = {The complex formation of the following diazaperylene ligands (L) 1,12-diazaperylene 1, 1,1-bisisoquinoline 2, 2,11-disubstituted 1,12-diazaperylenes (alkyl=methyl, ethyl, isopropyl, 3, 5, 7), 3,3-disubstituted 1,1-bisisoquinoline (alkyl=methyl, ethyl, isopropyl, 4, 6, 8 and with R=phenyl, 11 and with pyridine 12), and the 5,8-dimethoxy-substituted diazaperylene 9, 6,6-dimethoxy-substituted bisisoquinoline 10 with AgBF4 was investigated. Collision-induced dissociation measurements were used to evaluate the relative stabilities of the ligands themselves and for the [1:1](+) complexes as well as for the homoleptic and heteroleptic silver [1:2](+) complexes in the gas phase. This method is very useful in rapid screening of the stabilities of new complexes in the gas phase. The influence of the spatial arrangement of the ligands and the type of substituents employed for the complexation were examined. The effect of the preorganization of the diazaperylene on the threshold activation voltages and thus of the relative binding energies of the different complexes are discussed. Density functional theory calculations were used to calculate the optimized structures of the silver complexes and compared with the stabilities of the complexes in the gas phase for the first time.}, language = {en} } @article{HoldtMuellerKellingetal.2006, author = {Holdt, Hans-J{\"u}rgen and M{\"u}ller, Holger and Kelling, Alexandra and Drexler, Hans-Joachim and M{\"u}ller, Thomas and Schwarze, Thomas and Schilde, Uwe and Starke, Ines}, title = {Mercury(II) chloride and iodide complexes of dithia- and tetrathiacrown ethers}, issn = {0044-2313}, doi = {10.1002/zaac.200500281}, year = {2006}, abstract = {The complexes [(HgCl2)(2)((ch)(2)30S(4)O(6))] (1), [HgCl,(mn21S(2)O(5))] (2), [HgCl2(ch18S(2)O(4))] (3) and [HgI(meb12S(2)O(2))](2)[Hg2I6] (4) have been synthesized, characterized and their crystal structures were determined. In [(HgCl2)(2)((ch)(2)3OS(4)O(6))] two HgCl2 units are discretely bonded within the ligand cavity of the 30-membered dichinoxaline-tetrathia-30-crown-10 ((ch)(2)30S(4)O(6)) forming a binuclear complex. HgCl2 forms I : I "in-cavity" complexes with the 21-membered maleonitrile-dithia-21-crown-7(mn21S(2)O(5)) ligand and the 18-membered chinoxaline- dithia-18-crown-6 (ch18S(2)O(4)) ligand, respectively. The 12-membered 4-methyl-benzo-dithia-12-crown-4 (meb12S(2)O(2)) ligand gave with two equivalents HgI2 the compound [HgI(meb12S(2)O(2))](2)[Hg2I6]. In the cation [HgI(meb12S(2)O(2))](+) meb12S(2)O(2) forms with the cation HgI+ a half-sandwich complex}, language = {en} } @phdthesis{Starke1996, author = {Starke, Ines}, title = {Bestimmung der Konformation, der intramolekularen Beweglichkeit und der Komplexbildungstendenzen von Kronenethern}, pages = {99, XVII S.}, year = {1996}, language = {de} } @article{LeitenbergerHartmannPietschetal.2008, author = {Leitenberger, Wolfram and Hartmann, Robert and Pietsch, Ullrich and Andritschke, Robert and Starke, Ines and Str{\"u}der, Lothar}, title = {Application of a pnCCD in X-ray diffraction : a three-dimensional X-ray detector}, doi = {10.1107/S0909049508018931}, year = {2008}, abstract = {The first application of a pnCCD detector for X-ray scattering experiments using white synchrotron radiation at BESSY II is presented. A Cd arachidate multilayer was investigated in reflection geometry within the energy range 7 keV < E < 35 keV. At fixed angle of incidence the two-dimensional diffraction pattern containing several multilayer Bragg peaks and respective diffuse-resonant Bragg sheets were observed. Since every pixel of the detector is able to determine the energy of every incoming photon with a resolution Delta E/E similar or equal to 10(-2). a three-dimensional dataset is finally obtained. In order to achieve this energy resolution the detector was operated in the so-called single-photon- counting mode. A full dataset was evaluated taking into account all photons recorded within 10(5) detector frames at a readout rate of 200 Hz. By representing the data in reciprocal-space coordinates, it becomes obvious that this experiment with the pnCCD detector provides the same information as that obtained by combining a large number of monochromatic scattering experiments using conventional area detectors.}, language = {en} } @article{HoldtDrexlerStarkeetal.2001, author = {Holdt, Hans-J{\"u}rgen and Drexler, Hans-Joachim and Starke, Ines and Grotjahn, Manuela and Kleinpeter, Erich}, title = {Homologous series of the PdCl2 and PtCl2 complexes of maleonitrile-dithiacrown ethers : synthesis, crystal structures, NMR spectroscopy and mass spectrometry}, year = {2001}, language = {en} } @article{StarkeHolzbergerKammetal.2000, author = {Starke, Ines and Holzberger, Anja and Kamm, Birgit and Kleinpeter, Erich}, title = {Qualitative and quantitative analysis of carbohydrates in green juices (wild mix grass and alfalfa) from a green biorefinery by gas chromatography/mass spectrometry}, year = {2000}, language = {en} } @article{DrexlerStarkeGrojahnetal.1999, author = {Drexler, Hans-Joachim and Starke, Ines and Grojahn, Manuela and Reinke, H. and Kleinpeter, Erich and Holdt, Hans-J{\"u}rgen}, title = {SbCl3, BiCl3 and Na+ Complexes of maleonitrile-dithiacrown ethers: synthesis, crystal structures and DEP-MS experiments}, year = {1999}, language = {en} } @article{ReicheStarkeKleinpeteretal.1999, author = {Reiche, K. B. and Starke, Ines and Kleinpeter, Erich and Holdt, Hans-J{\"u}rgen and Pihlaja, Kalevi and Oksaman, P. and Ovcharenko, V. V.}, title = {Fragmentation of imine-type meta-bridged bis(benzo crown ether)s under electron impact}, year = {1999}, language = {en} }