@misc{SchatzOhlendorfBusseetal.2013, author = {Schatz, Juliane and Ohlendorf, Bernd and Busse, Peter and Pelz, Gerrit and Dolch, Dietrich and Teubner, Jens and Encarnacao, Jorge A. and M{\"u}hle, Ralf-Udo and Fischer, M. and Hoffmann, Bernd and Kwasnitschka, Linda and Balkema-Buschmann, Anne and Mettenleiter, Thomas Christoph and M{\"u}ller, T. and Freuling, Conrad M.}, title = {Twenty years of active bat rabies surveillance in Germany}, series = {Postprints der Universit{\"a}t Potsdam Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam Humanwissenschaftliche Reihe}, number = {533}, issn = {1866-8364}, doi = {10.25932/publishup-41514}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-415140}, pages = {12}, year = {2013}, abstract = {In Germany, active bat rabies surveillance was conducted between 1993 and 2012. A total of 4546 oropharyngeal swab samples from 18 bat species were screened for the presence of EBLV-1- , EBLV-2- and BBLV-specific RNA. Overall, 0 center dot 15\% of oropharyngeal swab samples tested EBLV-1 positive, with the majority originating from Eptesicus serotinus. Interestingly, out of seven RT-PCR-positive oropharyngeal swabs subjected to virus isolation, viable virus was isolated from a single serotine bat (E. serotinus). Additionally, about 1226 blood samples were tested serologically, and varying virus neutralizing antibody titres were found in at least eight different bat species. The detection of viral RNA and seroconversion in repeatedly sampled serotine bats indicates long-term circulation of the virus in a particular bat colony. The limitations of random-based active bat rabies surveillance over passive bat rabies surveillance and its possible application of targeted approaches for future research activities on bat lyssavirus dynamics and maintenance are discussed.}, language = {en} } @article{SchatzOhlendorfBusseetal.2014, author = {Schatz, J. and Ohlendorf, B. and Busse, P. and Pelz, G. and Dolch, D. and Teubner, J. and Encarnacao, Jorge A. and Muehle, Ralf -Udo and Fischer, M. and Hoffmann, B. and Kwasnitschka, L. and Balkema-Buschmann, Anne and Mettenleiter, Thomas Christoph and Mueller, T. and Freuling, C. M.}, title = {Twenty years of active bat rabies surveillance in Germany}, series = {Epidemiology and infection}, volume = {142}, journal = {Epidemiology and infection}, number = {6}, publisher = {Cambridge Univ. Press}, address = {New York}, issn = {0950-2688}, doi = {10.1017/S0950268813002185}, pages = {1155 -- 1166}, year = {2014}, abstract = {In Germany, active bat rabies surveillance was conducted between 1993 and 2012. A total of 4546 oropharyngeal swab samples from 18 bat species were screened for the presence of EBLV-1- , EBLV-2- and BBLV-specific RNA. Overall, 0 center dot 15\% of oropharyngeal swab samples tested EBLV-1 positive, with the majority originating from Eptesicus serotinus. Interestingly, out of seven RT-PCR-positive oropharyngeal swabs subjected to virus isolation, viable virus was isolated from a single serotine bat (E. serotinus). Additionally, about 1226 blood samples were tested serologically, and varying virus neutralizing antibody titres were found in at least eight different bat species. The detection of viral RNA and seroconversion in repeatedly sampled serotine bats indicates long-term circulation of the virus in a particular bat colony. The limitations of random-based active bat rabies surveillance over passive bat rabies surveillance and its possible application of targeted approaches for future research activities on bat lyssavirus dynamics and maintenance are discussed.}, language = {en} } @article{LandwehrKenzelZobelHoffmannetal.2018, author = {Landwehr-Kenzel, Sybille and Zobel, Anne and Hoffmann, Henrike and Landwehr, Niels and Schmueck-Henneresse, Michael and Schachtner, Thomas and Roemhild, Andy and Reinke, Petra}, title = {Ex vivo expanded natural regulatory T cells from patients with end-stage renal disease or kidney transplantation are useful for autologous cell therapy}, series = {Kidney international : official journal of the International Society of Nephrology}, volume = {93}, journal = {Kidney international : official journal of the International Society of Nephrology}, number = {6}, publisher = {Elsevier}, address = {New York}, issn = {0085-2538}, doi = {10.1016/j.kint.2018.01.021}, pages = {1452 -- 1464}, year = {2018}, abstract = {Novel concepts employing autologous, ex vivo expanded natural regulatory T cells (nTreg) for adoptive transfer has potential to prevent organ rejection after kidney transplantation. However, the impact of dialysis and maintenance immunosuppression on the nTreg phenotype and peripheral survival is not well understood, but essential when assessing patient eligibility. The current study investigates regulatory T-cells in dialysis and kidney transplanted patients and the feasibility of generating a clinically useful nTreg product from these patients. Heparinized blood from 200 individuals including healthy controls, dialysis patients with end stage renal disease and patients 1, 5, 10, 15, 20 years after kidney transplantation were analyzed. Differentiation and maturation of nTregs were studied by flow cytometry in order to compare dialysis patients and kidney transplanted patients under maintenance immunosuppression to healthy controls. CD127 expressing CD4(+)CD25(high)FoxP3(+) nTregs were detectable at increased frequencies in dialysis patients with no negative impact on the nTreg end product quality and therapeutic usefulness of the ex vivo expanded nTregs. Further, despite that immunosuppression mildly altered nTreg maturation, neither dialysis nor pharmacological immunosuppression or previous acute rejection episodes impeded nTreg survival in vivo. Accordingly, the generation of autologous, highly pure nTreg products is feasible and qualifies patients awaiting or having received allogenic kidney transplantation for adoptive nTreg therapy. Thus, our novel treatment approach may enable us to reduce the incidence of organ rejection and reduce the need of long-term immunosuppression.}, language = {en} } @article{HuelscherSobelKallniketal.2022, author = {H{\"u}lscher, Julian and Sobel, Edward R. and Kallnik, Niklas and Hoffmann, J. Elis and Millar, Ian L. and Hartmann, Kai and Bernhardt, Anne}, title = {Apatites record sedimentary provenance change 4-5 myrs before clay in the Oligocene/Miocene Alpine molasse}, series = {Frontiers in Earth Science}, volume = {10}, journal = {Frontiers in Earth Science}, publisher = {Frontiers Media}, address = {Lausanne}, issn = {2296-6463}, doi = {10.3389/feart.2022.914409}, pages = {16}, year = {2022}, abstract = {Extracting information about past tectonic or climatic environmental changes from sedimentary records is a key objective of provenance research. Interpreting the imprint of such changes remains challenging as signals might be altered in the sediment-routing system. We investigate the sedimentary provenance of the Oligocene/Miocene Upper Austrian Northern Alpine Foreland Basin and its response to the tectonically driven exhumation of the Tauern Window metamorphic dome (28 +/- 1 Ma) in the Eastern European Alps by using the unprecedented combination of Nd isotopic composition of bulk-rock clay-sized samples and partly previously published multi-proxy (Nd isotopic composition, trace-element geochemistry, U-Pb dating) sand-sized apatite single-grain analysis. The basin offers an excellent opportunity to investigate environmental signal propagation into the sedimentary record because comprehensive stratigraphic and seismic datasets can be combined with present research results. The bulk-rock clay-sized fraction epsilon Nd values of well-cutting samples from one well on the northern basin slope remained stable at similar to-9.7 from 27 to 19 Ma but increased after 19 Ma to similar to-9.1. In contrast, apatite single-grain distributions, which were extracted from 22 drill-core samples, changed significantly around 23.3 Ma from apatites dominantly from low-grade (