@article{SchlegerHeckSteinberg2000,
  author    = {Schleger, C. and Heck, R. and Steinberg, Pablo},
  title     = {The role of wild-type and mutated N-ras in the malignant transformation of liver cells},
  year      = {2000},
  language  = {en}
}
@article{VogelEbelSchuermannetal.2019,
  author    = {Vogel, Stefanie and Ebel, Kenny and Sch{\"u}rmann, Robin Mathis and Heck, Christian and Meiling, Till and Milosavljevic, Aleksandar R. and Giuliani, Alexandre and Bald, Ilko},
  title     = {Vacuum-UV and Low-Energy Electron-Induced DNA Strand Breaks},
  series = {ChemPhysChem : a European journal of chemical physics and physical chemistry},
  volume    = {20},
  journal   = {ChemPhysChem : a European journal of chemical physics and physical chemistry},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1439-4235},
  doi       = {10.1002/cphc.201801152},
  pages     = {823 -- 830},
  year      = {2019},
  abstract  = {DNA is effectively damaged by radiation, which can on the one hand lead to cancer and is on the other hand directly exploited in the treatment of tumor tissue. DNA strand breaks are already induced by photons having an energy below the ionization energy of DNA. At high photon energies, most of the DNA strand breaks are induced by low-energy secondary electrons. In the present study we quantified photon and electron induced DNA strand breaks in four different 12mer oligonucleotides. They are irradiated directly with 8.44 eV vacuum ultraviolet (VUV) photons and 8.8 eV low energy electrons (LEE). By using Si instead of VUV transparent CaF2 as a substrate the VUV exposure leads to an additional release of LEEs, which have a maximum energy of 3.6 eV and can significantly enhance strand break cross sections. Atomic force microscopy is used to visualize strand breaks on DNA origami platforms and to determine absolute values for the strand break cross sections. Upon irradiation with 8.44 eV photons all the investigated sequences show very similar strand break cross sections in the range of 1.7-2.3x10(-16) cm(2). The strand break cross sections for LEE irradiation at 8.8 eV are one to two orders of magnitude larger than the ones for VUV photons, and a slight sequence dependence is observed. The sequence dependence is even more pronounced for LEEs with energies <3.6 eV. The present results help to assess DNA damage by photons and electrons close to the ionization threshold.},
  language  = {en}
}
@article{VogelEbelHecketal.2019,
  author    = {Vogel, Stefanie and Ebel, Kenny and Heck, Christian and Sch{\"u}rmann, Robin Mathis and Milosavljevic, Aleksandar R. and Giuliani, Alexandre and Bald, Ilko},
  title     = {Vacuum-UV induced DNA strand breaks},
  series = {Physical chemistry, chemical physics : a journal of European Chemical Societies},
  volume    = {21},
  journal   = {Physical chemistry, chemical physics : a journal of European Chemical Societies},
  number    = {4},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {1463-9076},
  doi       = {10.1039/c8cp06813e},
  pages     = {1972 -- 1979},
  year      = {2019},
  abstract  = {Radiation therapy is a basic part of cancer treatment. To increase the DNA damage in carcinogenic cells and preserve healthy tissue at the same time, radiosensitizing molecules such as halogenated nucleobase analogs can be incorporated into the DNA during the cell reproduction cycle. In the present study 8.44 eV photon irradiation induced single strand breaks (SSB) in DNA sequences modified with the radiosensitizer 5-bromouracil (U-5Br) and 8-bromoadenine ((8Br)A) are investigated. U-5Br was incorporated in the 13mer oligonucleotide flanked by different nucleobases. It was demonstrated that the highest SSB cross sections were reached, when cytosine and thymine were adjacent to U-5Br, whereas guanine as a neighboring nucleobase decreases the activity of U-5Br indicating that competing reaction mechanisms are active. This was further investigated with respect to the distance of guanine to U-5Br separated by an increasing number of adenine nucleotides. It was observed that the SSB cross sections were decreasing with an increasing number of adenine spacers between guanine and U-5Br until the SSB cross sections almost reached the level of a non-modified DNA sequence, which demonstrates the high sequence dependence of the sensitizing effect of U-5Br. (8Br)A was incorporated in a 13mer oligonucleotide as well and the strand breaks were quantified upon 8.44 eV photon irradiation in direct comparison to a non-modified DNA sequence of the same composition. No clear enhancement of the SSB yield of the modified in comparison to the non-modified DNA sequence could be observed. Additionally, secondary electrons with a maximum energy of 3.6 eV were generated when using Si as a substrate giving rise to further DNA damage. A clear enhancement in the SSB yield can be ascertained, but to the same degree for both the non-modified DNA sequence and the DNA sequence modified with (8Br)A.},
  language  = {en}
}
@book{AckermannAhlgrimmApelojgetal.2018,
  author    = {Ackermann, Peter and Ahlgrimm, Frederik and Apelojg, Benjamin and B{\"o}rnert-Ringleb, Moritz and Borowski, Andreas and Ehlert, Antje and Eichler, Constanze and Frohn, Julia and Gehrmann, Marie-Luise and Gerlach, Erin and Goetz, Ilka and Goral, Johanna and Gronostaj, Anna and Grubert, Jana and G{\"u}lery{\"u}z, Burak and Hacke, Alexander and Heck, Sebastian and Hermanns, Jolanda and Hochmuth, J{\"o}rg and Jennek, Julia and Jostes, Brigitte and Jurczok, Anne and Kleemann, Katrin and Kortenkamp, Ulrich and Krauskopf, Karsten and K{\"u}choll, Denise and Kulawiak, Pawel R. and Lauterbach, Wolfgang and Lazarides, Rebecca and Linka, Tim and L{\"o}weke, Sebastian and Lohse-Bossenz, Hendrik and Maar, Verena and Nowak, Anna and Ratzlaff, Olaf and Reitz-Koncebovski, Karen and Rother, Stefanie and Scherreiks, Lynn and Schroeder, Christoph and Schwalbe, Anja and Schwill, Andreas and Tosch, Frank and Vock, Miriam and Wagner, Luisa and Westphal, Andrea and Wilbert, J{\"u}rgen},
  title     = {PSI-Potsdam},
  series = {Potsdamer Beitr{\"a}ge zur Lehrerbildung und Bildungsforschung},
  journal   = {Potsdamer Beitr{\"a}ge zur Lehrerbildung und Bildungsforschung},
  number    = {1},
  editor    = {Borowski, Andreas and Ehlert, Antje and Prechtl, Helmut},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-442-5},
  issn      = {2626-3556},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-414542},
  publisher      = {Universit{\"a}t Potsdam},
  pages     = {354},
  year      = {2018},
  abstract  = {In Brandenburg kommt der Universit{\"a}t Potsdam eine besondere Rolle zu: Sie ist die einzige, an der zuk{\"u}nftige Lehrerinnen und Lehrer die erste Phase ihres Werdegangs - das Lehramtsstudium - absolvieren k{\"o}nnen. Vor diesem Hintergrund wurde bereits kurz nach der Gr{\"u}ndung im Jahr 1991 das „Potsdamer Modell der Lehrerbildung" entwickelt. Dieses Modell strebt fortlaufend eine enge Verzahnung von Theorie und Praxis {\"u}ber das gesamte Studium hinweg an und bindet hierf{\"u}r die schulpraktischen Studienanteile in besonderer Weise ein. Eine erneute St{\"a}rkung erfuhr die Lehrerbildung im Dezember 2014 mit der Gr{\"u}ndung des Zentrums f{\"u}r Lehrerbildung und Bildungsforschung (ZeLB). Aus der koordinierenden Arbeit des Zentrums entstand das fakult{\"a}ts{\"u}bergreifende Projekt „Professionalisierung - Schulpraktische Studien - Inklusion" (PSI-Potsdam) das im Rahmen der Qualit{\"a}tsoffensive Lehrerbildung des Bundesministeriums f{\"u}r Bildung und Forschung erfolgreich gef{\"o}rdert wurde (2015-2018) und dessen Verl{\"a}ngerung (2019-2023) bewilligt ist. Der vorliegende Band vermittelt in den drei großen Kapiteln „Erhebungsinstrumente", „Seminarkonzepte" und „Vernetzungen" einen {\"U}berblick {\"u}ber einige der praxisnahen Forschungszug{\"a}nge, hochschuldidaktischen Ans{\"a}tze und Strategien zur Vernetzung innerhalb der Lehrerbildung, die im Rahmen von PSI-Potsdam entwickelt und umgesetzt wurden. Die Beitr{\"a}ge wurden mit dem Ziel verfasst, Kolleginnen und Kollegen an Universit{\"a}ten und Hochschulen, Akteur_innen des Vorbereitungsdiensts sowie der Fort- und Weiterbildung von Lehrkr{\"a}ften m{\"o}glichst konkrete Einblicke zu gew{\"a}hren. Unter der Herausgeberschaft von Prof. Dr. Andreas Borowski (Fachdidaktik Physik), Prof. Dr. Antje Ehlert (Inklusionsp{\"a}dagogik mit dem F{\"o}rderschwerpunkt Lernen) und Prof. Dr. Helmut Prechtl (Fachdidaktik Biologie) vereinen sich Autor_innen mit breit gestreuter fachdidaktischer und bildungswissenschaftlicher Expertise.},
  language  = {de}
}