@misc{WippertRectorKuhnetal.2017,
  author    = {Wippert, Pia-Maria and Rector, Michael V. and Kuhn, Gisela and Wuertz-Kozak, Karin},
  title     = {Stress and Alterations in Bones},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-395866},
  pages     = {7},
  year      = {2017},
  abstract  = {Decades of research have demonstrated that physical stress (PS) stimulates bone remodeling and affects bone structure and function through complex mechanotransduction mechanisms. Recent research has laid ground to the hypothesis that mental stress (MS) also influences bone biology, eventually leading to osteoporosis and increased bone fracture risk. These effects are likely exerted by modulation of hypothalamic-pituitary-adrenal axis activity, resulting in an altered release of growth hormones, glucocorticoids and cytokines, as demonstrated in human and animal studies. Furthermore, molecular cross talk between mental and PS is thought to exist, with either synergistic or preventative effects on bone disease progression depending on the characteristics of the applied stressor. This mini review will explain the emerging concept of MS as an important player in bone adaptation and its potential cross talk with PS by summarizing the current state of knowledge, highlighting newly evolving notions (such as intergenerational transmission of stress and its epigenetic modifications affecting bone) and proposing new research directions.},
  language  = {en}
}
@article{WippertRectorKuhnetal.2017,
  author    = {Wippert, Pia-Maria and Rector, Michael V. and Kuhn, Gisela and Wuertz-Kozak, Karin},
  title     = {Stress and Alterations in Bones},
  series = {Frontiers in endocrinology},
  volume    = {8},
  journal   = {Frontiers in endocrinology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-2392},
  doi       = {10.3389/fendo.2017.00096},
  pages     = {7},
  year      = {2017},
  abstract  = {Decades of research have demonstrated that physical stress (PS) stimulates bone remodeling and affects bone structure and function through complex mechanotransduction mechanisms. Recent research has laid ground to the hypothesis that mental stress (MS) also influences bone biology, eventually leading to osteoporosis and increased bone fracture risk. These effects are likely exerted by modulation of hypothalamic-pituitary-adrenal axis activity, resulting in an altered release of growth hormones, glucocorticoids and cytokines, as demonstrated in human and animal studies. Furthermore, molecular cross talk between mental and PS is thought to exist, with either synergistic or preventative effects on bone disease progression depending on the characteristics of the applied stressor. This mini review will explain the emerging concept of MS as an important player in bone adaptation and its potential cross talk with PS by summarizing the current state of knowledge, highlighting newly evolving notions (such as intergenerational transmission of stress and its epigenetic modifications affecting bone) and proposing new research directions.},
  language  = {en}
}
@misc{WuertzKozakRoszkowskiCambriaetal.2020,
  author    = {Wuertz-Kozak, Karin and Roszkowski, Martin and Cambria, Elena and Block, Andrea and Kuhn, Gisela A. and Abele, Thea and Hitzl, Wolfgang and Drießlein, David and M{\"u}ller, Ralph and Rapp, Michael A. and Mansuy, Isabelle M. and Peters, Eva M. J. and Wippert, Pia-Maria},
  title     = {Effects of Early Life Stress on Bone Homeostasis in Mice and Humans},
  series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  number    = {670},
  issn      = {1866-8364},
  doi       = {10.25932/publishup-48532},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-485324},
  pages     = {26},
  year      = {2020},
  abstract  = {Bone pathology is frequent in stressed individuals. A comprehensive examination of mechanisms linking life stress, depression and disturbed bone homeostasis is missing. In this translational study, mice exposed to early life stress (MSUS) were examined for bone microarchitecture (μCT), metabolism (qPCR/ELISA), and neuronal stress mediator expression (qPCR) and compared with a sample of depressive patients with or without early life stress by analyzing bone mineral density (BMD) (DXA) and metabolic changes in serum (osteocalcin, PINP, CTX-I). MSUS mice showed a significant decrease in NGF, NPYR1, VIPR1 and TACR1 expression, higher innervation density in bone, and increased serum levels of CTX-I, suggesting a milieu in favor of catabolic bone turnover. MSUS mice had a significantly lower body weight compared to control mice, and this caused minor effects on bone microarchitecture. Depressive patients with experiences of childhood neglect also showed a catabolic pattern. A significant reduction in BMD was observed in depressive patients with childhood abuse and stressful life events during childhood. Therefore, future studies on prevention and treatment strategies for both mental and bone disease should consider early life stress as a risk factor for bone pathologies.},
  language  = {en}
}
@article{WuertzKozakRoszkowskiCambriaetal.2020,
  author    = {Wuertz-Kozak, Karin and Roszkowski, Martin and Cambria, Elena and Block, Andrea and Kuhn, Gisela A. and Abele, Thea and Hitzl, Wolfgang and Drießlein, David and M{\"u}ller, Ralph and Rapp, Michael A. and Mansuy, Isabelle M. and Peters, Eva M. J. and Wippert, Pia-Maria},
  title     = {Effects of Early Life Stress on Bone Homeostasis in Mice and Humans},
  series = {International Journal of Molecular Sciences},
  volume    = {21},
  journal   = {International Journal of Molecular Sciences},
  number    = {18},
  publisher = {Molecular Diversity Preservation International},
  address   = {Basel},
  issn      = {1422-0067},
  doi       = {10.3390/ijms21186634},
  pages     = {24},
  year      = {2020},
  abstract  = {Bone pathology is frequent in stressed individuals. A comprehensive examination of mechanisms linking life stress, depression and disturbed bone homeostasis is missing. In this translational study, mice exposed to early life stress (MSUS) were examined for bone microarchitecture (μCT), metabolism (qPCR/ELISA), and neuronal stress mediator expression (qPCR) and compared with a sample of depressive patients with or without early life stress by analyzing bone mineral density (BMD) (DXA) and metabolic changes in serum (osteocalcin, PINP, CTX-I). MSUS mice showed a significant decrease in NGF, NPYR1, VIPR1 and TACR1 expression, higher innervation density in bone, and increased serum levels of CTX-I, suggesting a milieu in favor of catabolic bone turnover. MSUS mice had a significantly lower body weight compared to control mice, and this caused minor effects on bone microarchitecture. Depressive patients with experiences of childhood neglect also showed a catabolic pattern. A significant reduction in BMD was observed in depressive patients with childhood abuse and stressful life events during childhood. Therefore, future studies on prevention and treatment strategies for both mental and bone disease should consider early life stress as a risk factor for bone pathologies.},
  language  = {en}
}
@misc{DallapiazzaDenzFeinbergetal.2009,
  author    = {Dallapiazza, Michael and Denz, Rebekka and Feinberg, Anat and Ginsberg, Yona and Gr{\"o}zinger, Elvira and Gr{\"o}zinger, Karl E. and Hartwieg, Gisela and Hiscott, William and J{\"a}ckel, Eberhard and Jurewicz, Grażyna and J{\"u}tte, Robert and Knufinke, Ulrich and Kosman, Admiʾel and Kuhn, Rick and Messner, Philipp and Mualam, Nir and Pasdzierny, Matthias and Riemer, Nathanael and Shapira, Anita and Szulc, Michał and Ulmer, Martin and Wittkopf, Sarah},
  title     = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e.V. = 100j{\"a}hriges Jubil{\"a}um Tel Avivs},
  number    = {15},
  editor    = {Denz, Rebekka and Dubrau, Alexander and Riemer, Nathanael},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-012-0},
  issn      = {1862-7684},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-34600},
  year      = {2009},
  abstract  = {Aus dem Editorial: "Seit Anfang April diesen Jahres feiert Tel Aviv sein 100j{\"a}hriges Jubil{\"a}um. Bei {\"u}ber 400 verschiedenartigsten Veranstaltungen in dieser israelischen Stadt und in unz{\"a}hligen Orten außerhalb Israels wird 2009 {\"u}ber deren Geschichte res{\"u}miert, reflektiert sowie (kritisch) diskutiert. Dabei wird nicht nur die Geschichte der Stadt thematisiert, sondern gerade auch die Gegenwart und insbesondere deren Zukunft. Aus diesem Anlass weist die diesj{\"a}hrige Ausgabe von PaRDeS den Themenschwerpunkt 100 Jahre Tel Aviv /100th anniversary of Tel Aviv auf. Israelische, (zeitweise) in Tel Aviv oder in anderen L{\"a}ndern t{\"a}tige Wissenschaftlerinnen und Wissenschaftler n{\"a}hern sich aus mitunter sehr unterschiedlichen Perspektiven und Wissensbereichen der Geschichte und Gegenwart dieser gr{\"o}ßten israelischen Stadt. Anita Shapira er{\"o}ffnet mit Tel Aviv, a White City on the Sands den insgesamt sieben Artikel umfassenden Themenschwerpunkt. In ihrem Beitrag umreißt sie die Entstehungsgeschichte der israelischen Großstadt bis zur Gr{\"u}ndung des Staates Israel 1948. Shapira geht dabei insbesondere auf zionistische Ideen bei der Stadtgr{\"u}ndung und deren (stellenweise nicht) erfolgte Realisierung ein. In den 1920er und 30er Jahren wird das modernisierte Hebr{\"a}isch zur Triebfeder bei der Herausbildung einer neuen s{\"a}kular-j{\"u}dischen Kultur in Pal{\"a}stina. Innerhalb dieses Prozesses nimmt gerade die jungen Metropole Tel Aviv eine bedeutende Rolle ein. Philipp Messner beschreibt in seinem Beitrag Tel Aviv und die Revolution des hebr{\"a}ischen Schriftbilds diese Umw{\"a}lzungen auf der graphisch-{\"a}sthetischen Ebene des hebr{\"a}ischen Schriftbildes. In ihrem Artikel Von der Einwanderung der Jekim zu ihrer politischen Partizipation bei den Wahlen zum Tel Aviver Stadtrat im Jahr 1936 zeigt Sarah Wittkopf anhand des Publikationsorgans Mitteilungsblatt der Irgun Olej Merkas Europa welchen Widerst{\"a}nden die Einwanderer aus den deutschsprachigen L{\"a}ndern bei der Mitgestaltung der Politik in Pal{\"a}stina ausgesetzt waren. Im Zentrum der Auseinandersetzungen in Tel Aviv steht der Spitzenkandidat der Einwandererorganisation Felix Rosenbl{\"u}th. Im vierten Artikel Building a Modern Jewish City: Projects of the Architect Wilhelm Zeev Haller in Tel Aviv stellt Ulrich Knufinke Kontinuit{\"a}tslinien und -br{\"u}che im architektonischen Schaffen Wilhelm Zeev Hallers zwischen Europa und Tel Aviv dar." [die Herausgeber] PaRDeS, die Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e.V., m{\"o}chte die fruchtbare und facettenreiche Kultur des Judentums sowie seine Ber{\"u}hrungspunkte zur Umwelt in den unterschiedlichen Bereichen dokumentieren. Daneben dient die Zeitschrift als Forum zur Positionierung der F{\"a}cher J{\"u}dische Studien und Judaistik innerhalb des wissenschaftlichen Diskurses sowie zur Diskussion ihrer historischen und gesellschaftlichen Verantwortung.},
  language  = {de}
}