@article{ArndtEsserWeirichetal.2015, author = {Arndt, Larissa R. and Esser, G{\"u}nter and Weirich, Sebastian and Oelsner, Henriette and Ebersbach, Georg and Bengner, Thomas}, title = {Face Memory in Idiopathic Parkinson's Disease Moderated by Sex and Encoding Duration}, series = {Zeitschrift f{\"u}r Neuropsychologie}, volume = {26}, journal = {Zeitschrift f{\"u}r Neuropsychologie}, number = {2}, publisher = {Hogrefe}, address = {Bern}, issn = {1016-264X}, doi = {10.1024/1016-264X/a000148}, pages = {109 -- 120}, year = {2015}, abstract = {We examined face memory deficits in patients with Idiopathic Parkinson's disease (IPD) with specific regard to the moderating role of sex and the different memory processes involved. We tested short- and long-term face recognition memory in 18 nonclinical participants and 18 IPD-patients matched for sex, education and age. We varied the duration of item presentation (1, 5, 10s), the time of testing (immediately, 1hr, 24hrs) and the possibility to re-encode items. In accordance with earlier studies, we report face memory deficits in IPD. Moreover, our findings indicate that sex and encoding conditions may be important moderator variables. In contrast to healthy individuals, IPD-patients cannot gain from increasing duration of presentation. Furthermore, our results suggest that I PD leads to face memory deficits in women, only.}, language = {en} } @article{VogelClausAhringetal.2022, author = {Vogel, Annemarie and Claus, Inga and Ahring, Sigrid and Gruber, Doreen and Haghikia, Aiden and Frank, Ulrike and Dziewas, Rainer and Ebersbach, Georg and Gandor, Florin and Warnecke, Tobias}, title = {Endoscopic characteristics of dysphagia in multiple system atrophy}, series = {Movement disorders : official journal of the Movement Disorder Society}, volume = {37}, journal = {Movement disorders : official journal of the Movement Disorder Society}, number = {3}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {0885-3185}, doi = {10.1002/mds.28854}, pages = {535 -- 544}, year = {2022}, abstract = {Background Dysphagia is a major clinical concern in multiple system atrophy (MSA). A detailed evaluation of its major endoscopic features compared with Parkinson's disease (PD) is lacking. Objective This study systematically assessed dysphagia in MSA compared with PD and correlated subjective dysphagia to objective endoscopic findings. Methods Fifty-seven patients with MSA (median, 64 [interquartile range (IQR): 59-71] years; 35 women) underwent flexible endoscopic evaluation of swallowing using a specific MSA-flexible endoscopic evaluation of swallowing task protocol. Findings were compared with an age-matched cohort of 57 patients with PD (median, 67 [interquartile range: 60-73] years; 28 women). In a subcohort, subjective dysphagia was assessed using the Swallowing Disturbance Questionnaire and correlated to endoscopy findings. Results Patients with MSA predominantly showed symptoms suggestive of oral-phase disturbance (premature spillage, 75.4\%, piecemeal deglutition, 75.4\%). Pharyngeal-phase symptoms occurred less often (pharyngeal residues, 50.9\%; penetration/aspiration, 28.1\%). In contrast, pharyngeal symptoms were the most common finding in PD (pharyngeal residues, 47.4\%). Oral symptoms occurred less frequently in PD (premature spillage, 15.8\%, P < 0.001; piecemeal deglutition, 1.8\%, P < 0.01). Patients with MSA had a greater risk for oral-phase disturbances with increased disease severity (P < 0.05; odds ratio, 3.15). Patients with MSA showed a significantly higher intraindividual interswallow variability compared with PD. When correlating Swallowing Disturbance Questionnaire scores with endoscopy results, its cutoff, validated for PD, was not sensitive enough to identify patients with MSA with dysphagia. We developed a subscore for identifying dysphagia in MSA and calculated a new cutoff (sensitivity 85\%, specificity 100\%). Conclusions In contrast with patients with PD, patients with dysphagic MSA more frequently present with oral-phase symptoms and a significantly higher intraindividual interswallow variability. A novel Swallowing Disturbance Questionnaire MSA subscore may be a valuable tool to identify patients with MSA with early oropharyngeal dysphagia.}, language = {en} }