@article{ZhangTimmArndtetal.2010, author = {Zhang, Fuzhong Z. and Timm, Katharina A. and Arndt, Katja Maren and Woolley, G. Andrew}, title = {Photocontrol of Coiled-Coil Proteins in Living Cells}, issn = {1433-7851}, doi = {10.1002/anie.201000909}, year = {2010}, abstract = {Light switching of the activity of a coiled-coil protein, the AP-1 transcription factor, in living cells was made possible by the introduction of a designed azobenzene-cross-linked dominant negative peptide, XAFosW (red and yellow in the picture). In the dark, XAFosW showed decreased helical content and decreased affinity for target Jun proteins (green); irradiation at 365 nm enhanced helicity and target affinity.}, language = {en} }