@article{BierEhrentreichFoersterSchelleretal.1996, author = {Bier, Frank Fabian and Ehrentreich-F{\"o}rster, Eva and Scheller, Frieder W. and Makower, Alexander and Eremenko, A. V. and Wollenberger, Ursula and Bauer, Christian G. and Pfeiffer, Dorothea and Micheel, Burkhard}, title = {Ultrasensitive biosensors}, year = {1996}, language = {en} } @article{GhindilisMakowerBaueretal.1995, author = {Ghindilis, A. L. and Makower, Alexander and Bauer, Christian G. and Bier, Frank Fabian and Scheller, Frieder W.}, title = {Determination of p-aminophenol and catecholamines at picomolar concentrations based on recycling enzyme amplification}, year = {1995}, language = {en} } @article{SchellerMakowerBieretal.1995, author = {Scheller, Frieder W. and Makower, Alexander and Bier, Frank Fabian and Wollenberger, Ursula and Ghindilis, A. L. and Eremenko, A. V. and Pfeiffer, Dorothea}, title = {Enzymsensoren zur Bestimmung subnanomolarer Konzentrationen}, year = {1995}, language = {de} } @article{BierEhrentreichFoersterMakoweretal.1996, author = {Bier, Frank Fabian and Ehrentreich-F{\"o}rster, Eva and Makower, Alexander and Scheller, Frieder W.}, title = {An enzymatic amplification cycle for high sensitive immunoassay}, year = {1996}, language = {en} } @article{SongBierScheller1995, author = {Song, Min Ik and Bier, Frank Fabian and Scheller, Frieder W.}, title = {A method to detect superoxide radicals using teflon membrane and superoxide dismutase}, year = {1995}, language = {en} } @article{SchellerBierPfeiffer1995, author = {Scheller, Frieder W. and Bier, Frank Fabian and Pfeiffer, Dorothea}, title = {Biosensoren : Grundlagen und Anwendungen}, year = {1995}, language = {de} } @article{SchellerMakowerGhindilisetal.1995, author = {Scheller, Frieder W. and Makower, Alexander and Ghindilis, A. L. and Bier, Frank Fabian and Ehrentreich-F{\"o}rster, Eva and Wollenberger, Ursula and Bauer, Christian G. and Micheel, Burkhard and Pfeiffer, Dorothea and Szeponik, Jan and Michael, N. and Kaden, H.}, title = {Enzyme sensors for subnanomolar concentrations}, year = {1995}, language = {en} } @article{JinWollenbergerBieretal.1995, author = {Jin, Wen and Wollenberger, Ursula and Bier, Frank Fabian and Scheller, Frieder W.}, title = {Construction and characterization of multi-layer-enzyme electrode : covalent binding of quinoprotein glucose dehydrogenase onto gold electrodes}, year = {1995}, language = {en} } @misc{BierYinKleinjungetal.1995, author = {Bier, Frank Fabian and Yin, Wen and Kleinjung, Frank and Scheller, Frieder W.}, title = {Molekulare Schichten zur Analyse biochemischer Bindungen und Umsatzreaktionen}, year = {1995}, language = {de} } @article{KleinjungBierScheller1995, author = {Kleinjung, Frank and Bier, Frank Fabian and Scheller, Frieder W.}, title = {Messungen an Nukleins{\"a}uren mittels evaneszenten Feldes}, year = {1995}, language = {de} } @article{BierSchellerKlingbeiletal.1993, author = {Bier, Frank Fabian and Scheller, Frieder W. and Klingbeil, Mandy and Oßwald, U.}, title = {Biosensoren und Teststreifen f{\"u}r die Umwelt- und Lebensmittelanalytik : eine {\"U}bersicht}, year = {1993}, language = {de} } @article{SchellerBierNeumann1994, author = {Scheller, Frieder W. and Bier, Frank Fabian and Neumann, B.}, title = {Bioindikation in aquatischen {\"O}kosystemen : Bioindikation in limnischen und k{\"u}stennahen {\"O}kosystemen ; Grundlagen, Verfahren und Methoden}, publisher = {Fischer}, address = {Jena}, pages = {S. 380 - 386}, year = {1994}, language = {de} } @article{DechtriratGajovicEichelmannWojciketal.2014, author = {Dechtrirat, Decha and Gajovic-Eichelmann, Nenad and Wojcik, Felix and Hartmann, Laura and Bier, Frank Fabian and Scheller, Frieder W.}, title = {Electrochemical displacement sensor based on ferrocene boronic acid tracer and immobilized glycan for saccharide binding proteins and E. coli}, series = {Biosensors and bioelectronics : the principal international journal devoted to research, design development and application of biosensors and bioelectronics}, volume = {58}, journal = {Biosensors and bioelectronics : the principal international journal devoted to research, design development and application of biosensors and bioelectronics}, publisher = {Elsevier}, address = {Oxford}, issn = {0956-5663}, doi = {10.1016/j.bios.2014.02.028}, pages = {1 -- 8}, year = {2014}, abstract = {Pathogens such as viruses and bacteria use their envelope proteins and their adhesin lectins to recognize the glycan residues presented on the cell surface of the target tissues. This principle of recognition is used in a new electrochemical displacement sensor for the protein concanavalin A (ConA). A gold electrode was first modified with a self-assembled monolayer of a thiolated mannose/OEG conjugate and a ferrocene boroxol derivative was pre-assembled as reporter molecule onto the mannose surface. The novel tracer molecule based on a 2-hydroxymethyl phenyl boronic acid derivative binds even at neutral pH to the saccharides which could expand the application towards biological samples (i.e., urine and feces). Upon the binding of ConA, the tracer was displaced and washed away from the sensor surface leading to a decrease in the electrochemical signal. Using square wave voltammetry (SWV), the concentration of ConA in the sample solution could be determined in the dynamic concentration range established from 38 nmol L-1 to 5.76 mu mol L-1 with a reproducible detection limit of 1 mu g mL(-1) (38 nmol L-1) based on the signal-to-noise ratio (S/N=3) with fast response of 15 min. The new reporter molecule showed a reduced non-specific displacement by BSA and ribonuclease A. The sensor was also successfully transferred to the first proof of principle for the detection of Escherichia coli exhibiting a detection limit of approximately 6 x 102 cells/mL Specificity of the displacement by target protein ConA and E. coli was demonstrated since the control proteins (i.e., BSA and RNaseA) and the control E. coli strain, which lack of type 1 fimbriae, were ineffective. (C) 2014 Elsevier B.V. All rights reserved.}, language = {en} } @article{SchellerYarmanBachmannetal.2014, author = {Scheller, Frieder W. and Yarman, Aysu and Bachmann, Till and Hirsch, Thomas and Kubick, Stefan and Renneberg, Reinhard and Schumacher, Soeren and Wollenberger, Ursula and Teller, Carsten and Bier, Frank Fabian}, title = {Future of biosensors: a personal view}, series = {Advances in biochemical engineering, biotechnology}, volume = {140}, journal = {Advances in biochemical engineering, biotechnology}, editor = {Gu, MB and Kim, HS}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-642-54143-8; 978-3-642-54142-1}, issn = {0724-6145}, doi = {10.1007/10_2013_251}, pages = {1 -- 28}, year = {2014}, abstract = {Biosensors representing the technological counterpart of living senses have found routine application in amperometric enzyme electrodes for decentralized blood glucose measurement, interaction analysis by surface plasmon resonance in drug development, and to some extent DNA chips for expression analysis and enzyme polymorphisms. These technologies have already reached a highly advanced level and need minor improvement at most. The dream of the "100-dollar' personal genome may come true in the next few years provided that the technological hurdles of nanopore technology or of polymerase-based single molecule sequencing can be overcome. Tailor-made recognition elements for biosensors including membrane-bound enzymes and receptors will be prepared by cell-free protein synthesis. As alternatives for biological recognition elements, molecularly imprinted polymers (MIPs) have been created. They have the potential to substitute antibodies in biosensors and biochips for the measurement of low-molecular-weight substances, proteins, viruses, and living cells. They are more stable than proteins and can be produced in large amounts by chemical synthesis. Integration of nanomaterials, especially of graphene, could lead to new miniaturized biosensors with high sensitivity and ultrafast response. In the future individual therapy will include genetic profiling of isoenzymes and polymorphic forms of drug-metabolizing enzymes especially of the cytochrome P450 family. For defining the pharmacokinetics including the clearance of a given genotype enzyme electrodes will be a useful tool. For decentralized online patient control or the integration into everyday "consumables' such as drinking water, foods, hygienic articles, clothing, or for control of air conditioners in buildings and cars and swimming pools, a new generation of "autonomous' biosensors will emerge.}, language = {en} } @article{StoeckleinWarsinkeScheller1997, author = {St{\"o}cklein, Walter F. M. and Warsinke, Axel and Scheller, Frieder W.}, title = {Organic solvent modified enzyme-liked immunoassay for the detection of triazine herbicides}, year = {1997}, language = {en} } @article{SchellerSchubertFederowitz1997, author = {Scheller, Frieder W. and Schubert, Frank and Federowitz, J.}, title = {Present state and frontiers in biosensorics}, year = {1997}, language = {en} } @article{StoeckleinScheller1997, author = {St{\"o}cklein, Walter F. M. and Scheller, Frieder W.}, title = {Enzymes and antibodies in organic media : analytical applications}, year = {1997}, language = {en} } @article{WollenbergerLisdatScheller1997, author = {Wollenberger, Ursula and Lisdat, Fred and Scheller, Frieder W.}, title = {Enzymatic substrade recycling electrodes}, year = {1997}, language = {en} } @article{EremenkoMakowerBaueretal.1997, author = {Eremenko, A. V. and Makower, Alexander and Bauer, Christian G. and Kurochkin, I. N. and Scheller, Frieder W.}, title = {A bienzyme electrode for tyrosine containing peptides determination}, year = {1997}, language = {en} } @article{XieTangWollenbergeretal.1997, author = {Xie, B. and Tang, X. and Wollenberger, Ursula and Johansson, G. and Gorton, Lo and Scheller, Frieder W. and Danielsson, B.}, title = {Hybrid biosensor for simultaneous electrochemical and thermal detection}, year = {1997}, language = {en} }