@article{EmmerlingOrgzallRecketal.2006, author = {Emmerling, Franziska and Orgzall, Ingo and Reck, G{\"u}nter and Schulz, Burkhard W. and Stockhause, Sabine and Schulz, Burkhard}, title = {Structures of substituted di-aryl-1, 3,4-oxadiazole derivatives: 2,5-bis(pyridyl)- and 2,5-bis(aminophenyl)-substitution}, series = {Journal of molecular structure}, volume = {800}, journal = {Journal of molecular structure}, number = {1-3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-2860}, doi = {10.1016/j.molstruc.2006.03.076}, pages = {74 -- 84}, year = {2006}, abstract = {Crystal structures of four different di-aryl-1,3,4-oxadiazole compounds (aryl = 2-pyridyl-, 3-pyridyl-, 2-aminophenyl-, 3-aminophenyl-) are determined. Crystallization of di(2-pyridyl)-1,3,4-oxadiazole yielded monoclinic and triclinic polymorphs. The structures are characterized by the occurrence of pi-pi interactions. Additionally, in case of the aminophenyl compounds intra- as well as intermolecular hydrogen bonds are found that influence the packing motif as well. Since these molecules are often used as ligands in metal-organic complexes similarities and differences of the molecular conformation between the molecules in the pure crystals and that of the ligands in the complexes are discussed. (c) 2006 Elsevier B.V. All rights reserved.}, language = {en} } @misc{KuehneMeindersMohretal.2016, author = {K{\"u}hne, Franziska and Meinders, C. and Mohr, H. and Hafenbrack, K. and Kieseritzky, K. and Rosenberger, C. and Haerter, M. and Schulz-Kindermann, F. and Klinger, R. and Nestoriuc, A. Y.}, title = {Psychological treatments for pain in cancer patients. A systematic review on the current state of research}, series = {Der Schmerz : Organ der Deutschen Gesellschaft zum Studium des Schmerzes, der {\~A}-sterreichischen Schmerzgesellschaft und der Deutschen Interdisziplin{\~A}\iren Vereinigung f{\~A}¼r Schmerztherapie}, volume = {30}, journal = {Der Schmerz : Organ der Deutschen Gesellschaft zum Studium des Schmerzes, der {\~A}-sterreichischen Schmerzgesellschaft und der Deutschen Interdisziplin{\~A}\iren Vereinigung f{\~A}¼r Schmerztherapie}, publisher = {Springer}, address = {New York}, issn = {0932-433X}, doi = {10.1007/s00482-016-0169-7}, pages = {496 -- 509}, year = {2016}, abstract = {In cancer patients, pain is one of the main symptoms and especially in the late stages of disease, these symptoms can be associated with considerable suffering. In psycho-oncology, preliminary psychological therapies targeting cancer pain have been tested; however, a systematic review of available interventions is lacking, especially considering their dissemination, evidence base, study quality, and the comparison with established treatments. Therefore, the aim of the current study is to systematically review the current research on psychological treatments for pain in cancer patients. During May 2014, MEDLINE, PsycINFO, PSYNDEX, and CENTRAL databases were searched. Psychological treatments for pain in adult cancer patients studied in randomized, controlled trials (RCTs) and referring to pain as primary or secondary outcome were included. After examination for inclusion, structured data extraction and assessment followed. Data were synthesized narratively. In the review, 32 RCTs were included. Studies mainly referred to patients with breast cancer or patients in earlier stages of the disease. The methodological quality of included studies was heterogeneous. Most commonly, short interventions were delivered by nurses in out-patient settings. Interventions including education and relaxation techniques were utilized most often, followed by interventions with behavioral or cognitive components. A need for research persists regarding efficacy of current psychotherapeutic interventions, or the role of mediator variables (e. g., coping) on pain perception in cancer patients. Studies with high methodological quality which comprehensively and transparently report on interventions and designs are lacking.}, language = {de} } @misc{SchulzWyschkonGallitetal.2018, author = {Schulz, Franziska and Wyschkon, Anne and Gallit, Finja Sunnyi and Poltz, Nadine and Moraske, Svenja and Kucian, Karin and von Aster, Michael G. and Esser, G{\"u}nter}, title = {Rechenprobleme von Grundschulkindern}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, number = {634}, issn = {1866-8364}, doi = {10.25932/publishup-44138}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-441388}, pages = {67 -- 80}, year = {2018}, abstract = {Fragestellung: Ziel war die Untersuchung des Verlaufs von Kindern mit Rechenst{\"o}rungen bzw. Rechenschw{\"a}chen. Neben der Persistenz wurden Auswirkungen von Rechenproblemen auf k{\"u}nftige Rechenleistungen sowie den Schulerfolg gepr{\"u}ft. Methodik: F{\"u}r 2909 Sch{\"u}ler der 2. bis 5. Klasse liegen die Resultate standardisierter Rechen- und Intelligenztests vor. Ein Teil dieser Kinder ist nach 37 und 68 Mona-ten erneut untersucht worden. Ergebnisse: Die Pr{\"a}valenz von Rechenst{\"o}rungen betrug 1.4 \%, Rechenschw{\"a}chen traten bei 11.2 \% auf. Rechen-probleme zeigten eine mittlere bis hohe Persistenz. Sch{\"u}ler mit Rechenschw{\"a}che blieben im Rechnen gut eine Standardabweichung hinter durchschnittlich und ca. eine halbe Standardabweichung hinter unterdurchschnittlich intelligenten Kontrollkindern zur{\"u}ck. Der allgemeine Schulerfolg rechenschwacher Probanden (definiert {\"u}ber Mathematiknote, Deutschnote und Schultyp) {\"a}hnelte dem der unterdurchschnittlich intelligenten Kontrollgruppe und blieb hinter dem Schulerfolg durchschnittlich intelligenter Kontrollkinder zur{\"u}ck. Eingangs {\"a}ltere Probanden mit Rechenproblemen (4. bis 5. Klasse) wiesen eine schlechtere Prognose auf als Kinder, die zu Beginn die 2. oder 3. Klasse besuchten. Schluss-folgerungen: Rechenprobleme stellen ein ernsthaftes Entwicklungsrisiko dar. L{\"a}ngsschnittuntersuchungen, die Kinder mit streng definierter Rechenst{\"o}rung bis ins Erwachsenenalter begleiten und Pr{\"a}diktoren f{\"u}r unterschiedlich erfolgreiche Verl{\"a}ufe ermitteln, sind dringend notwendig.}, language = {de} } @misc{KuehneMeindersMohretal.2017, author = {K{\"u}hne, Franziska and Meinders, C. and Mohr, H. and Hafenbrack, K. and Kieseritzky, K. and Rosenberger, C. and Haerter, M. and Schulz-Kindermann, F. and Klinger, R. and Nestoriuc, A. Y.}, title = {Psychologische Interventionen zur Schmerzreduktion}, series = {Der Schmerz}, volume = {31}, journal = {Der Schmerz}, publisher = {Springer}, address = {New York}, issn = {0932-433X}, doi = {10.1007/s00482-017-0223-0}, pages = {404 -- 404}, year = {2017}, abstract = {Der Leserbrief fokussiert in weiten Teilen auf das Gutachterwesen, weshalb wir ausschließlich auf die inhaltlichen Punkte im Zusammenhang mit unserer Arbeit eingehen. Untersucht wurden schmerzpsychologische Interventionen, wie beschrieben definiert als psychologische Interventionen, deren prim{\"a}res Ziel die Schmerzreduktion war. Die extrahierten Zielgr{\"o}ßen, wie Lebensqualit{\"a}t oder Depressivit{\"a}t, ergaben sich aus den in den Prim{\"a}rstudien untersuchten Hauptoutcomes und nicht aus der Suchstrategie. Zur Einsch{\"a}tzung der methodischen Qualit{\"a}t der Prim{\"a}rstudien konnte ein Kriterium des von Johannsen und Kollegen [2] gebildeten Scores nicht ber{\"u}cksichtigt werden, da die eingeschlossenen Prim{\"a}rstudien keine metaanalytische Zusammenfassung erlaubten. Stellt man dies in Rechnung, bleibt die Vergleichbarkeit beider Werte erhalten. Die Evidenzsynthese erfolgte narrativ in Text- und Tabellenform, d. h. in Form einer strukturierten Zusammenfassung und Diskussion von Studien [1]. Um unsere Arbeit zu fokussieren, h{\"a}tten wir eine weitergehende Gegen{\"u}berstellung wie auch eine {\"U}berpr{\"u}fung von Zitaten und {\"U}bersetzungen selbstverst{\"a}ndlich vorgenommen, wenn wir den Hinweis dazu vor Publikation erhalten h{\"a}tten.}, language = {de} } @article{MeyerSchulzJeibmannetal.2014, author = {Meyer, S{\"o}ren and Schulz, J. and Jeibmann, A. and Taleshi, M. S. and Ebert, Franziska and Francesconi, Kevin A. and Schwerdtle, Tanja}, title = {Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster}, series = {Metallomics : integrated biometal science}, volume = {6}, journal = {Metallomics : integrated biometal science}, number = {11}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1756-5901}, doi = {10.1039/c4mt00249k}, pages = {2010 -- 2014}, year = {2014}, abstract = {Arsenic-containing hydrocarbons (AsHC) constitute one group of arsenolipids that have been identified in seafood. In this first in vivo toxicity study for AsHCs, we show that AsHCs exert toxic effects in Drosophila melanogaster in a concentration range similar to that of arsenite. In contrast to arsenite, however, AsHCs cause developmental toxicity in the late developmental stages of Drosophila melanogaster. This work illustrates the need for a full characterisation of the toxicity of AsHCs in experimental animals to finally assess the risk to human health related to the presence of arsenolipids in seafood.}, language = {en} } @article{HoffmannDietzelSchulzetal.2011, author = {Hoffmann, Katrin and Dietzel, Birgit and Schulz, Burkhard and Reck, Guenter and Hoffmann, Angelika and Orgzall, Ingo and Resch-Genger, Ute and Emmerling, Franziska}, title = {Combined structural and fluorescence studies of methyl-substituted 2,5-diphenyl-1,3,4-oxadiazoles - Relation between electronic properties and packing motifs}, series = {Journal of molecular structure}, volume = {988}, journal = {Journal of molecular structure}, number = {1-3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-2860}, doi = {10.1016/j.molstruc.2010.11.071}, pages = {35 -- 46}, year = {2011}, abstract = {Prerequisite for the rational design of functional organic materials with tailor-made electronic properties is the knowledge of the structure-property relationship for the specific class of molecules under consideration. This encouraged us to systematically study the influence of the molecular structure and substitution pattern of aromatically substituted 1,3,4-oxadiazoles on the electronic properties and packing motifs of these molecules and on the interplay of these factors. For this purpose, seven diphenyl-oxadiazoles equipped with methyl substituents in the ortho- and meta-position(s) were synthesized and characterized. Absorption and fluorescence spectra in solution served here as tools to monitor substitution-induced changes in the electronic properties of the individual molecules whereas X-ray and optical measurements in the solid state provided information on the interplay of electronic and packing effects. In solution, the spectral position of the absorption maximum, the size of Stokes shift, and the fluorescence quantum yield are considerably affected by ortho-substitution in three or four ortho-positions. This results in blue shifted absorption bands, increased Stokes shifts, and reduced fluorescence quantum yields whereas the spectral position and vibrational structure of the emission bands remain more or less unaffected. In the crystalline state, however, the spectral position and shape of the emission bands display a strong dependence on the molecular structure and/or packing motifs that seem to control the amount of dye-dye-interactions. These observations reveal the limited value of commonly reported absorption and fluorescence measurements in solution for a straightforward comparison of spectroscopic results with single X-ray crystallography. This underlines the importance of solid state spectroscopic studies for a better understanding of the interplay of electronic effects and molecular order.}, language = {en} } @article{EmmerlingOrgzallDietzeletal.2012, author = {Emmerling, Franziska and Orgzall, Ingo and Dietzel, Birgit and Schulz, Burkhard and Larrucea, Julen}, title = {Ordering the amorphous - Structures in PBD LED materials}, series = {Journal of molecular structure}, volume = {1030}, journal = {Journal of molecular structure}, number = {23}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0022-2860}, doi = {10.1016/j.molstruc.2012.04.040}, pages = {209 -- 215}, year = {2012}, abstract = {The class of 2,5 disubstituted-1,3,4-oxadiazoles containing a biphenyl unit on one side is intensively used as electron transport materials to enhance the performance of organic light emitting diodes (OLEDs). In contrast to the ongoing research on these materials insights in their structure-property relationships are still incomplete. To overcome the structural tentativeness and ambiguities the crystal structures of 2-(4-biphenylyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole, that of the related compound 2-(4-biphenylyl)-5-phenyl-1,3,4-oxadiazole and of 2-(4-biphenylyl)-5-(2,6-dimethylphenyl)-1,3,4-oxadiazole are determined. A comparison with the results of GAUSSIAN03 calculations and similar compounds in the Cambridge Structural Database leads to a profound characterization.}, language = {en} } @misc{MeyerSchulzJeibmannetal.2014, author = {Meyer, S{\"o}ren and Schulz, Jacqueline and Jeibmann, Astrid and Taleshi, Mojtaba S. and Ebert, Franziska and Francesconi, Kevin and Schwerdtle, Tanja}, title = {Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster}, volume = {11}, number = {6}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-76819}, pages = {2010 -- 2014}, year = {2014}, abstract = {Arsenic-containing hydrocarbons (AsHC) constitute one group of arsenolipids that have been identified in seafood. In this first in vivo toxicity study for AsHCs, we show that AsHCs exert toxic effects in Drosophila melanogaster in a concentration range similar to that of arsenite. In contrast to arsenite, however, AsHCs cause developmental toxicity in the late developmental stages of Drosophila melanogaster. This work illustrates the need for a full characterisation of the toxicity of AsHCs in experimental animals to finally assess the risk to human health related to the presence of arsenolipids in seafood.}, language = {en} } @article{MeyerSchulzJeibmannetal.2014, author = {Meyer, S{\"o}ren and Schulz, Jacqueline and Jeibmann, Astrid and Taleshi, Mojtaba S. and Ebert, Franziska and Francesconi, Kevin and Schwerdtle, Tanja}, title = {Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster}, series = {Metallomics}, journal = {Metallomics}, editor = {Schwerdtle, Tanja}, publisher = {The Royal Society of Chemistry}, address = {Cambridge}, issn = {1756-5901}, pages = {2010 -- 2014}, year = {2014}, abstract = {Arsenic-containing hydrocarbons (AsHC) constitute one group of arsenolipids that have been identified in seafood. In this first in vivo toxicity study for AsHCs, we show that AsHCs exert toxic effects in Drosophila melanogaster in a concentration range similar to that of arsenite. In contrast to arsenite, however, AsHCs cause developmental toxicity in the late developmental stages of Drosophila melanogaster. This work illustrates the need for a full characterisation of the toxicity of AsHCs in experimental animals to finally assess the risk to human health related to the presence of arsenolipids in seafood.}, language = {en} } @article{SpeckmannSchulzHilleretal.2017, author = {Speckmann, Bodo and Schulz, Sarah and Hiller, Franziska and Hesse, Deike and Schumacher, Fabian and Kleuser, Burkhard and Geisel, Juergen and Obeid, Rima and Grune, Tilman and Kipp, Anna Patricia}, title = {Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice}, series = {The journal of nutritional biochemistry}, volume = {48}, journal = {The journal of nutritional biochemistry}, publisher = {Elsevier}, address = {New York}, issn = {0955-2863}, doi = {10.1016/j.jnutbio.2017.07.002}, pages = {112 -- 119}, year = {2017}, abstract = {The average intake of the essential trace element selenium (Se) is below the recommendation in most European countries, possibly causing sub-optimal expression of selenoproteins. It is still unclear how a suboptimal Se status may affect health. To mimic this situation, mice were fed one of three physiologically relevant amounts of Se. We focused on the liver, the organ most sensitive to changes in the Se supply indicated by hepatic glutathione peroxidase activity. In addition, liver is the main organ for synthesis of methyl groups and glutathione via one-carbon metabolism. Accordingly, the impact of Se on global DNA methylation, methylation capacity, and gene expression was assessed. We observed higher global DNA methylation indicated by LINE1 methylation, and an increase of the methylation potential as indicated by higher S-adenosylmethionine (SAM)/S-adenosylhomocysteine (SAH) ratio and by elevated mRNA expression of serine hydroxymethyltransferase in both or either of the Se groups. Furthermore, increasing the Se supply resulted in higher plasma concentrations of triglycerides. Hepatic expression of glycolytic and lipogenic genes revealed consistent Se dependent up-regulation of glucokinase. The sterol regulatory element-binding transcription factor 1 (Srebf1) was also up-regulated by Se. Both effects were confirmed in primary hepatocytes. In contrast to the overall Se-dependent increase of methylation capacity, the up-regulation of Srebf1 expression was paralleled by reduced local methylation of a specific CpG site within the Srebf1 gene. Thus, we provided evidence that Se-dependent effects on lipogenesis involve epigenetic mechanisms. (C) 2017 The Authors. Published by Elsevier Inc.}, language = {en} }