@misc{SchruenderLenzenZimmermannGoerlichetal.2012, author = {Schr{\"u}nder-Lenzen, Agi and Zimmermann, Matthias and G{\"o}rlich, Petra and Horn-Conrad, Antje and Geller, Katrin and Eckardt, Barbara and Hoffmann, Florian and Pyanoe, Steffi and Kampe, Heike and J{\"a}ger, Sophie and Reinhardt, Ragna}, title = {Portal = Zwischen Freiheit und Verantwortung: Ethik in der Forschung}, number = {02/2012}, organization = {Universit{\"a}t Potsdam, Referat f{\"u}r Presse- und {\"O}ffentlichkeitsarbeit}, issn = {1618-6893}, doi = {10.25932/publishup-44047}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-440475}, pages = {42}, year = {2012}, abstract = {Aus dem Inhalt: - Zwischen Freiheit und Verantwortung: Ethik in der Forschung - Die Grenzen der Grammatik - Ein Bild von einem Mann}, language = {de} } @misc{GuentherGoerlichHoffmannetal.2012, author = {G{\"u}nther, Oliver and G{\"o}rlich, Petra and Hoffmann, Florian and Zimmermann, Matthias and J{\"a}ger, Sophie and Weise, Aileen and Wiehn, Tanja and Eckardt, Barbara and Rost, Sophia and Klein, Armin and Eulenfeld, Sophie}, title = {Portal = Zwischen H{\"o}rsaal und Trainingsplatz: Studium und Leistungssport}, number = {03/2012}, organization = {Universit{\"a}t Potsdam, Referat f{\"u}r Presse- und {\"O}ffentlichkeitsarbeit}, issn = {1618-6893}, doi = {10.25932/publishup-44048}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-440488}, pages = {42}, year = {2012}, abstract = {Aus dem Inhalt: - Zwischen H{\"o}rsaal und Trainingsplatz: Studium und Leistungssport - Studieren sans souci - Brisante Farbenlehre}, language = {de} } @article{SaguTchewonpiZimmermannLandgraeberetal.2020, author = {Sagu Tchewonpi, Sorel and Zimmermann, Lynn and Landgr{\"a}ber, Eva and Homann, Thomas and Huschek, Gerd and {\"O}zpinar, Haydar and Schweigert, Florian J. and Rawel, Harshadrai Manilal}, title = {Comprehensive Characterization and Relative Quantification of α-Amylase/Trypsin Inhibitors from Wheat Cultivars by Targeted HPLC-MS/MS}, series = {Foods}, volume = {9}, journal = {Foods}, number = {10}, publisher = {MDPI}, address = {Basel}, issn = {2304-8158}, doi = {10.3390/foods9101448}, pages = {25}, year = {2020}, abstract = {The α-amylase/trypsin inhibitors (ATIs) are discussed as being responsible for non-celiac wheat sensitivity (NCWS), besides being known as allergenic components for baker's asthma. Different approaches for characterization and quantification including proteomics-based methods for wheat ATIs have been documented. In these studies generally the major ATIs have been addressed. The challenge of current study was then to develop a more comprehensive workflow encompassing all reviewed wheat-ATI entries in UniProt database. To substantially test proof of concept, 46 German and Turkish wheat samples were used. Two extractions systems based on chloroform/methanol mixture (CM) and under buffered denaturing conditions were evaluated. Three aspects were optimized, tryptic digestion, chromatographic separation, and targeted tandem mass spectrometric analysis (HPLC-MS/MS). Preliminary characterization with sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) documented the purity of the extracted ATIs with CM mixture and the amylase (60-80\%)/trypsin (10-20\%) inhibition demonstrated the bifunctional activity of ATIs. Thirteen (individual/common) biomarkers were established. Major ATIs (7-34\%) were differently represented in samples. Finally, to our knowledge, the proposed HPLC-MS/MS method allowed for the first time so far the analysis of all 14 reviewed wheat ATI entries reported.}, language = {en} } @misc{SaguTchewonpiZimmermannLandgraeberetal.2020, author = {Sagu Tchewonpi, Sorel and Zimmermann, Lynn and Landgr{\"a}ber, Eva and Homann, Thomas and Huschek, Gerd and {\"O}zpinar, Haydar and Schweigert, Florian J. and Rawel, Harshadrai Manilal}, title = {Comprehensive Characterization and Relative Quantification of α-Amylase/Trypsin Inhibitors from Wheat Cultivars by Targeted HPLC-MS/MS}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {1028}, issn = {1866-8372}, doi = {10.25932/publishup-48611}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-486118}, pages = {27}, year = {2020}, abstract = {The α-amylase/trypsin inhibitors (ATIs) are discussed as being responsible for non-celiac wheat sensitivity (NCWS), besides being known as allergenic components for baker's asthma. Different approaches for characterization and quantification including proteomics-based methods for wheat ATIs have been documented. In these studies generally the major ATIs have been addressed. The challenge of current study was then to develop a more comprehensive workflow encompassing all reviewed wheat-ATI entries in UniProt database. To substantially test proof of concept, 46 German and Turkish wheat samples were used. Two extractions systems based on chloroform/methanol mixture (CM) and under buffered denaturing conditions were evaluated. Three aspects were optimized, tryptic digestion, chromatographic separation, and targeted tandem mass spectrometric analysis (HPLC-MS/MS). Preliminary characterization with sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) documented the purity of the extracted ATIs with CM mixture and the amylase (60-80\%)/trypsin (10-20\%) inhibition demonstrated the bifunctional activity of ATIs. Thirteen (individual/common) biomarkers were established. Major ATIs (7-34\%) were differently represented in samples. Finally, to our knowledge, the proposed HPLC-MS/MS method allowed for the first time so far the analysis of all 14 reviewed wheat ATI entries reported.}, language = {en} } @article{BuchmannKopfWestphaletal.2010, author = {Buchmann, Arlette F. and Kopf, Daniel and Westphal, Sabine and Lederbogen, Florian and Banaschewski, Tobias and Esser, G{\"u}nter and Schmidt, Martin H. and Zimmermann, Ulrich S. and Laucht, Manfred and Deuschle, Michael}, title = {Impact of early parental child-rearing behavior on young adults' cardiometabolic risk profile : a prospective study}, issn = {0033-3174}, doi = {10.1097/Psy.0b013e3181c88343}, year = {2010}, abstract = {Objective: To examine prospectively whether early parental child-rearing behavior is a predictor of cardiometabolic outcome in young adulthood when other potential risk factors are controlled. Metabolic factors associated with increased risk for cardiovascular disease have been found to vary, depending on lifestyle as well as genetic predisposition. Moreover, there is evidence suggesting that environmental conditions, such as stress in pre- and postnatal life, may have a sustained impact on an individual's metabolic risk profile. Methods: Participants were drawn from a prospective, epidemiological, cohort study followed up from birth into young adulthood. Parent interviews and behavioral observations at the age of 3 months were conducted to assess child-rearing practices and mother-infant interaction in the home setting and in the laboratory. In 279 participants, anthropometric characteristics, low-density lipoprotein and high-density lipoprotein cholesterol, apolipoproteins, and triglycerides were recorded at age 19 years. In addition, structured interviews were administered to the young adults to assess indicators of current lifestyle and education. Results: Adverse early-life interaction experiences were significantly associated with lower levels of high- density lipoprotein cholesterol and apolipoprotein A1 in young adulthood. Current lifestyle variables and level of education did not account for this effect, although habitual smoking and alcohol consumption also contributed significantly to cardiometabolic outcomes. Conclusions: These findings suggest that early parental child-rearing behavior may predict health outcome in later life through its impact on metabolic parameters in adulthood.}, language = {en} } @misc{SchurrPagelSarmentoetal.2012, author = {Schurr, Frank Martin and Pagel, J{\"o}rn and Sarmento, Juliano Sarmento and Groeneveld, Juergen and Bykova, Olga and O'Hara, Robert B. and Hartig, Florian and Kissling, W. Daniel and Linder, H. Peter and Midgley, Guy F. and Schr{\"o}der-Esselbach, Boris and Singer, Alexander and Zimmermann, Niklaus E.}, title = {How to understand species' niches and range dynamics: a demographic research agenda for biogeography}, series = {Journal of biogeography}, volume = {39}, journal = {Journal of biogeography}, number = {12}, publisher = {Wiley-Blackwell}, address = {Hoboken}, issn = {0305-0270}, doi = {10.1111/j.1365-2699.2012.02737.x}, pages = {2146 -- 2162}, year = {2012}, abstract = {Range dynamics causes mismatches between a species geographical distribution and the set of suitable environments in which population growth is positive (the Hutchinsonian niche). This is because sourcesink population dynamics cause species to occupy unsuitable environments, and because environmental change creates non-equilibrium situations in which species may be absent from suitable environments (due to migration limitation) or present in unsuitable environments that were previously suitable (due to time-delayed extinction). Because correlative species distribution models do not account for these processes, they are likely to produce biased niche estimates and biased forecasts of future range dynamics. Recently developed dynamic range models (DRMs) overcome this problem: they statistically estimate both range dynamics and the underlying environmental response of demographic rates from species distribution data. This process-based statistical approach qualitatively advances biogeographical analyses. Yet, the application of DRMs to a broad range of species and study systems requires substantial research efforts in statistical modelling, empirical data collection and ecological theory. Here we review current and potential contributions of these fields to a demographic understanding of niches and range dynamics. Our review serves to formulate a demographic research agenda that entails: (1) advances in incorporating process-based models of demographic responses and range dynamics into a statistical framework, (2) systematic collection of data on temporal changes in distribution and abundance and on the response of demographic rates to environmental variation, and (3) improved theoretical understanding of the scaling of demographic rates and the dynamics of spatially coupled populations. This demographic research agenda is challenging but necessary for improved comprehension and quantification of niches and range dynamics. It also forms the basis for understanding how niches and range dynamics are shaped by evolutionary dynamics and biotic interactions. Ultimately, the demographic research agenda should lead to deeper integration of biogeography with empirical and theoretical ecology.}, language = {en} } @misc{MusilZimmermannGoerlichetal.2018, author = {Musil, Andreas and Zimmermann, Matthias and G{\"o}rlich, Petra and Stolte, Josephine and Pavel, Florian and Eckardt, Barbara and Scholz, Jana and Szameitat, Ulrike and Engel, Silke and Kampe, Heike}, title = {Portal = Im Fokus: Qualit{\"a}t im Studium}, number = {01/2018}, organization = {Universit{\"a}t Potsdam, Referat f{\"u}r Presse- und {\"O}ffentlichkeitsarbeit}, issn = {1618-6893}, doi = {10.25932/publishup-44072}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-440721}, pages = {42}, year = {2018}, abstract = {Aus dem Inhalt: - Im Fokus: Qualit{\"a}t im Studium - Kakteen in Infrarot - Pollenjagd in Sibirien}, language = {de} } @unpublished{GrapentinHeidlerKorschetal.2014, author = {Grapentin, Andreas and Heidler, Kirstin and Korsch, Dimitri and Kumar Sah, Rakesh and Kunzmann, Nicco and Henning, Johannes and Mattis, Toni and Rein, Patrick and Seckler, Eric and Groneberg, Bj{\"o}rn and Zimmermann, Florian}, title = {Embedded operating system projects}, number = {90}, editor = {Hentschel, Uwe and Richter, Daniel and Polze, Andreas}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-296-4}, issn = {1613-5652}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-69154}, pages = {xi, 87}, year = {2014}, abstract = {In today's life, embedded systems are ubiquitous. But they differ from traditional desktop systems in many aspects - these include predictable timing behavior (real-time), the management of scarce resources (memory, network), reliable communication protocols, energy management, special purpose user-interfaces (headless operation), system configuration, programming languages (to support software/hardware co-design), and modeling techniques. Within this technical report, authors present results from the lecture "Operating Systems for Embedded Computing" that has been offered by the "Operating Systems and Middleware" group at HPI in Winter term 2013/14. Focus of the lecture and accompanying projects was on principles of real-time computing. Students had the chance to gather practical experience with a number of different OSes and applications and present experiences with near-hardware programming. Projects address the entire spectrum, from bare-metal programming to harnessing a real-time OS to exercising the full software/hardware co-design cycle. Three outstanding projects are at the heart of this technical report. Project 1 focuses on the development of a bare-metal operating system for LEGO Mindstorms EV3. While still a toy, it comes with a powerful ARM processor, 64 MB of main memory, standard interfaces, such as Bluetooth and network protocol stacks. EV3 runs a version of 1 1 Introduction Linux. Sources are available from Lego's web site. However, many devices and their driver software are proprietary and not well documented. Developing a new, bare-metal OS for the EV3 requires an understanding of the EV3 boot process. Since no standard input/output devices are available, initial debugging steps are tedious. After managing these initial steps, the project was able to adapt device drivers for a few Lego devices to an extent that a demonstrator (the Segway application) could be successfully run on the new OS. Project 2 looks at the EV3 from a different angle. The EV3 is running a pretty decent version of Linux- in principle, the RT_PREEMPT patch can turn any Linux system into a real-time OS by modifying the behavior of a number of synchronization constructs at the heart of the OS. Priority inversion is a problem that is solved by protocols such as priority inheritance or priority ceiling. Real-time OSes implement at least one of the protocols. The central idea of the project was the comparison of non-real-time and real-time variants of Linux on the EV3 hardware. A task set that showed effects of priority inversion on standard EV3 Linux would operate flawlessly on the Linux version with the RT_PREEMPT-patch applied. If only patching Lego's version of Linux was that easy... Project 3 takes the notion of real-time computing more seriously. The application scenario was centered around our Carrera Digital 132 racetrack. Obtaining position information from the track, controlling individual cars, detecting and modifying the Carrera Digital protocol required design and implementation of custom controller hardware. What to implement in hardware, firmware, and what to implement in application software - this was the central question addressed by the project.}, language = {en} } @article{GuentherSchueleZurelletal.2023, author = {G{\"u}nther, Oliver and Sch{\"u}le, Manja and Zurell, Damaris and Jeltsch, Florian and Roeleke, Manuel and Kampe, Heike and Zimmermann, Matthias and Scholz, Jana and Engbert, Ralf and Elsner, Birgit and Schlangen, David and Agrofylax, Luisa and Georgi, Doreen and Weymar, Mathias and Wagener, Thorsten and Bookhagen, Bodo and Eibl, Eva P. S. and Korup, Oliver and Oswald, Sascha and Thieken, Annegret and van der Beek, Pieter A.}, title = {Portal Wissen = Exzellenz}, series = {Portal Wissen: Das Forschungsmagazin der Universit{\"a}t Potsdam}, journal = {Portal Wissen: Das Forschungsmagazin der Universit{\"a}t Potsdam}, number = {02/2023}, issn = {2194-4245}, doi = {10.25932/publishup-61144}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-611440}, pages = {98}, year = {2023}, abstract = {Was nicht nur gut oder sehr gut ist, nennen wir gern exzellent. Aber was meint das eigentlich? Vom lateinischen „excellere" kommend, beschreibt es Dinge, Personen oder Handlungen, die „hervor-" oder „herausragen" aus der Menge, sich „auszeichnen" gegen{\"u}ber anderen. Mehr geht nicht. Exzellenz ist das Mittel der Wahl, wenn es darum geht, der Erste oder Beste zu sein. Und das macht auch vor der Forschung nicht halt. Wer auf die Universit{\"a}t Potsdam schaut, findet zahlreiche ausgezeichnete Forschende, hervorragende Projekte und immer wieder auch aufsehenerregende Erkenntnisse, Ver{\"o}ffentlichungen und Ergebnisse. Aber ist die UP auch exzellent? Eine Frage, die 2023 ganz sicher andere Wellen schl{\"a}gt als vielleicht vor 20 Jahren. Denn seit dem Start der Exzellenzinitiative 2005 gelten als - w{\"o}rtlich - exzellent jene Hochschulen, denen es gelingt, in dem umfangreichsten F{\"o}rderprogramm f{\"u}r Wissenschaft in Deutschland einen Zuschlag zu erhalten. Egal ob in Form von Graduiertenschulen, Forschungsclustern oder - seit Fortsetzung des Programms ab 2019 unter dem Titel „Exzellenzstrategie" - ganzen Exzellenzuniversit{\"a}ten: Wer im Kreis der Forschungsuniversit{\"a}ten zu den Besten geh{\"o}ren will, braucht das Siegel der Exzellenz. In der gerade eingel{\"a}uteten neuen Wettbewerbsrunde der „Exzellenzstrategie des Bundes und der L{\"a}nder" bewirbt sich die Universit{\"a}t Potsdam mit drei Clusterskizzen um F{\"o}rderung. Ein Antrag kommt aus der {\"O}kologie- und Biodiversit{\"a}tsforschung. Ziel ist es, ein komplexes Bild {\"o}kologischer Prozesse zu zeichnen - und dabei die Rolle von einzelnen Individuen ebenso zu betrachten wie das Zusammenwirken vieler Arten in einem {\"O}kosystem, um die Funktion der Artenvielfalt genauer zu bestimmen. Eine zweite Skizze haben die Kognitionswissenschaften eingereicht. Hier soll das komplexe Nebeneinander von Sprache und Kognition, Entwicklung und Lernen sowie Motivation und Verhalten als dynamisches Miteinander erforscht werden - wobei auch mit den Erziehungswissenschaften kooperiert wird, um verkn{\"u}pfte Lernund Bildungsprozesse stets mitzudenken. Der dritte Antrag aus den Geo- und Umweltwissenschaften nimmt extreme und besonders folgenschwere Naturgefahren und -prozesse wie {\"U}berschwemmungen und D{\"u}rren in den Blick. Die Forschenden untersuchen die Extremereignisse mit besonderem Fokus auf deren Wechselwirkung mit der Gesellschaft, um mit ihnen einhergehende Risiken und Sch{\"a}den besser einsch{\"a}tzen sowie k{\"u}nftig rechtzeitig Maßnahmen einleiten zu k{\"o}nnen. „Alle drei Antr{\"a}ge zeichnen ein hervorragendes Bild unserer Leistungsf{\"a}higkeit", betont der Pr{\"a}sident der Universit{\"a}t, Prof. Oliver G{\"u}nther, Ph.D. „Die Skizzen dokumentieren eindrucksvoll unser Engagement, vorhandene Forschungsexzellenz sowie die Potenziale der Universit{\"a}t Potsdam insgesamt. Allein die Tatsache, dass sich drei schlagkr{\"a}ftige Konsortien in ganz unterschiedlichen Themenbereichen zusammengefunden haben, zeigt, dass wir auf unserem Weg in die Spitzengruppe der deutschen Universit{\"a}ten einen guten Schritt vorangekommen sind." In diesem Heft schauen wir, was sich in und hinter diesen Antr{\"a}gen verbirgt: Wir haben mit den Wissenschaftlerinnen und Wissenschaftlern gesprochen, die sie geschrieben haben, und sie gefragt, was sie sich vornehmen, sollten sie den Zuschlag erhalten und ein Cluster an die Universit{\"a}t holen. Wir haben aber auch auf die Forschung geschaut, die zu den Antr{\"a}gen gef{\"u}hrt hat und die schon l{\"a}nger das Profil der Universit{\"a}t pr{\"a}gt und ihr national wie international Anerkennung eingebracht hat. Wir stellen eine kleine Auswahl an Projekten, Methoden und Forschenden vor, um zu zeigen, warum in diesen Antr{\"a}gen tats{\"a}chlich exzellente Forschung steckt! {\"U}brigens: Auch „Exzellenz" ist nicht das Ende der Fahnenstange. Immerhin l{\"a}sst sich das Adjektiv exzellent sogar steigern. In diesem Sinne w{\"u}nschen wir exzellentestes Vergn{\"u}gen beim Lesen!}, language = {de} } @article{GarbusowSchadSommeretal.2014, author = {Garbusow, Maria and Schad, Daniel and Sommer, Christian and Juenger, Elisabeth and Sebold, Miriam and Friedel, Eva and Wendt, Jean and Kathmann, Norbert and Schlagenhauf, Florian and Zimmermann, Ulrich S. and Heinz, Andreas and Huys, Quentin J. M. and Rapp, Michael A.}, title = {Pavlovian-to-instrumental transfer in alcohol dependence: a pilot study}, series = {Neuropsychobiology : international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography}, volume = {70}, journal = {Neuropsychobiology : international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography}, number = {2}, publisher = {Karger}, address = {Basel}, issn = {0302-282X}, doi = {10.1159/000363507}, pages = {111 -- 121}, year = {2014}, abstract = {Background: Pavlovian processes are thought to play an important role in the development, maintenance and relapse of alcohol dependence, possibly by influencing and usurping ongoing thought and behavior. The influence of pavlovian stimuli on ongoing behavior is paradigmatically measured by pavlovian-to-instrumental transfer (PIT) tasks. These involve multiple stages and are complex. Whether increased PIT is involved in human alcohol dependence is uncertain. We therefore aimed to establish and validate a modified PIT paradigm that would be robust, consistent and tolerated by healthy controls as well as by patients suffering from alcohol dependence, and to explore whether alcohol dependence is associated with enhanced PIT. Methods: Thirty-two recently detoxified alcohol-dependent patients and 32 age- and gender-matched healthy controls performed a PIT task with instrumental go/no-go approach behaviors. The task involved both pavlovian stimuli associated with monetary rewards and losses, and images of drinks. Results: Both patients and healthy controls showed a robust and temporally stable PIT effect. Strengths of PIT effects to drug-related and monetary conditioned stimuli were highly correlated. Patients more frequently showed a PIT effect, and the effect was stronger in response to aversively conditioned CSs (conditioned suppression), but there was no group difference in response to appetitive CSs. Conclusion: The implementation of PIT has favorably robust properties in chronic alcohol-dependent patients and in healthy controls. It shows internal consistency between monetary and drug-related cues. The findings support an association of alcohol dependence with an increased propensity towards PIT.}, language = {en} }