@article{BeyeOebergXinetal.2016, author = {Beye, Martin and {\"O}berg, Henrik and Xin, Hongliang and Dakovski, Georgi L. and F{\"o}hlisch, Alexander and Gladh, Jorgen and Hantschmann, Markus and Hieke, Florian and Kaya, Sarp and K{\"u}hn, Danilo and LaRue, Jerry and Mercurio, Giuseppe and Minitti, Michael P. and Mitra, Ankush and Moeller, Stefan P. and Ng, May Ling and Nilsson, Anders and Nordlund, Dennis and Norskov, Jens and {\"O}str{\"o}m, Henrik and Ogasawara, Hirohito and Persson, Mats and Schlotter, William F. and Sellberg, Jonas A. and Wolf, Martin and Abild-Pedersen, Frank and Pettersson, Lars G. M. and Wurth, Wilfried}, title = {Chemical Bond Activation Observed with an X-ray Laser}, series = {The journal of physical chemistry letters}, volume = {7}, journal = {The journal of physical chemistry letters}, publisher = {American Chemical Society}, address = {Washington}, issn = {1948-7185}, doi = {10.1021/acs.jpclett.6b01543}, pages = {3647 -- 3651}, year = {2016}, abstract = {The concept of bonding and antibonding orbitals is fundamental in chemistry. The population of those orbitals and the energetic difference between the two reflect the strength of the bonding interaction. Weakening the bond is expected to reduce this energetic splitting, but the transient character of bond-activation has so far prohibited direct experimental access. Here we apply time-resolved soft X-ray spectroscopy at a free electron laser to directly observe the decreased bonding antibonding splitting following bond-activation using an ultrashort optical laser pulse.}, language = {en} } @article{RuscheDuplouyKuhnetal.2011, author = {Rusche, Tim Maxian and Duplouy, Florent and Kuhn, Florian and von Oettingen, Anna}, title = {Deutsche Interessen}, series = {WeltTrends-Papiere}, journal = {WeltTrends-Papiere}, number = {20}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1864-0656}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-62837}, pages = {56 -- 59}, year = {2011}, abstract = {Inhalt: Interessen, Werte und Normen bedingen sich wechselseitig! Werte und Normen lassen sich als Interessen definieren! Debattenkultur gegen das Informationsdefizit! Was ist deutsch an deutschen Interessen?}, language = {de} } @misc{RuscheBielawskiRiemannetal.2010, author = {Rusche, Tim Maxian and Bielawski, Martina and Riemann, Silke and Reimers, Lutz and Duplouy, Florent and Kuhn, Florian and von Oettingen, Anna}, title = {Deutsche Interessen offen diskutieren!}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-41636}, year = {2010}, abstract = {Außenpolitik ist von den Werten, dem Selbstverst{\"a}ndnis einer Gesellschaft und den {\"o}konomischen Interessen ihrer Volkswirtschaft gepr{\"a}gt. In den ersten beiden Teilen dieses Essays zeigen wir auf, wie Deutschland seine Werte behutsam erneuern sollte und welche Bereiche zur Wahrung seines {\"o}konomischen Wohlstands zentral sind. Auf dieses Fundament setzen wir ein Pl{\"a}doyer f{\"u}r eine neue außenpolitische Kultur, die Interessen offen debattiert und klar definiert, um sie erfolgreich durchzusetzen.}, language = {de} } @article{RuscheBielawskiRiemannetal.2011, author = {Rusche, Tim Maxian and Bielawski, Martina and Riemann, Silke and Reimers, Lutz and Duplouy, Florent and Kuhn, Florian and von Oettingen, Anna}, title = {Deutsche Interessen offen diskutieren!}, series = {WeltTrends-Papiere}, journal = {WeltTrends-Papiere}, number = {20}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1864-0656}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-62734}, pages = {9 -- 17}, year = {2011}, abstract = {Inhalt: 1. Werte und Selbstverst{\"a}ndnis behutsam erneuern Globalisierung Demografischer Wandel Klimawandel 2. Langfristig {\"o}konomischen Wohlstand sichern Bildung Forschung und Entwicklung Außenwirtschaft 3. Pl{\"a}doyer f{\"u}r eine neue außenpolitische Kultur : Deutsche Interessen - Ein Anachronismus? Status quo: Interessendefinition im Hinterzimmer Interessen klar definieren und erfolgreich durchsetzen Entscheidungsmatrix f{\"u}r Auslandseins{\"a}tze Evaluierung des Nutzens Evaluierung der Kosten Ableiten der Entscheidung Und die Moral? - Aber sicher! Der T{\"o}nissteiner Kreis}, language = {de} } @article{StedeKuhn2009, author = {Stede, Manfred and Kuhn, Florian}, title = {Identifying the content zones of German court decisions}, isbn = {978-3-642- 03423-7}, year = {2009}, language = {en} } @misc{SchaeferKakularamReischetal.2022, author = {Sch{\"a}fer, Marj{\"a}nn Helena and Kakularam, Kumar Reddy and Reisch, Florian and Rothe, Michael and Stehling, Sabine and Heydeck, Dagmar and P{\"u}schel, Gerhard Paul and Kuhn, Hartmut}, title = {Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {1295}, issn = {1866-8372}, doi = {10.25932/publishup-57649}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-576491}, pages = {22}, year = {2022}, abstract = {Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in cell differentiation and in the pathogenesis of inflammation. The mouse genome involves seven functional Alox genes and the encoded enzymes share a high degree of amino acid conservation with their human orthologs. There are, however, functional differences between mouse and human ALOX orthologs. Human ALOX15B oxygenates arachidonic acid exclusively to its 15-hydroperoxy derivative (15S-HpETE), whereas 8S-HpETE is dominantly formed by mouse Alox15b. The structural basis for this functional difference has been explored and in vitro mutagenesis humanized the reaction specificity of the mouse enzyme. To explore whether this mutagenesis strategy may also humanize the reaction specificity of mouse Alox15b in vivo, we created Alox15b knock-in mice expressing the arachidonic acid 15-lipoxygenating Tyr603Asp+His604Val double mutant instead of the 8-lipoxygenating wildtype enzyme. These mice are fertile, display slightly modified plasma oxylipidomes and develop normally up to an age of 24 weeks. At later developmental stages, male Alox15b-KI mice gain significantly less body weight than outbred wildtype controls, but this effect was not observed for female individuals. To explore the possible reasons for the observed gender-specific growth arrest, we determined the basic hematological parameters and found that aged male Alox15b-KI mice exhibited significantly attenuated red blood cell parameters (erythrocyte counts, hematocrit, hemoglobin). Here again, these differences were not observed in female individuals. These data suggest that humanization of the reaction specificity of mouse Alox15b impairs the functionality of the hematopoietic system in males, which is paralleled by a premature growth arrest.}, language = {en} } @article{SchaeferKakularamReischetal.2022, author = {Sch{\"a}fer, Marj{\"a}nn Helena and Kakularam, Kumar Reddy and Reisch, Florian and Rothe, Michael and Stehling, Sabine and Heydeck, Dagmar and P{\"u}schel, Gerhard Paul and Kuhn, Hartmut}, title = {Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging}, series = {Biomedicines}, volume = {10}, journal = {Biomedicines}, edition = {6}, publisher = {MDPI}, address = {Basel, Schweiz}, issn = {2227-9059}, doi = {10.3390/biomedicines10061379}, pages = {1 -- 22}, year = {2022}, abstract = {Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in cell differentiation and in the pathogenesis of inflammation. The mouse genome involves seven functional Alox genes and the encoded enzymes share a high degree of amino acid conservation with their human orthologs. There are, however, functional differences between mouse and human ALOX orthologs. Human ALOX15B oxygenates arachidonic acid exclusively to its 15-hydroperoxy derivative (15S-HpETE), whereas 8S-HpETE is dominantly formed by mouse Alox15b. The structural basis for this functional difference has been explored and in vitro mutagenesis humanized the reaction specificity of the mouse enzyme. To explore whether this mutagenesis strategy may also humanize the reaction specificity of mouse Alox15b in vivo, we created Alox15b knock-in mice expressing the arachidonic acid 15-lipoxygenating Tyr603Asp+His604Val double mutant instead of the 8-lipoxygenating wildtype enzyme. These mice are fertile, display slightly modified plasma oxylipidomes and develop normally up to an age of 24 weeks. At later developmental stages, male Alox15b-KI mice gain significantly less body weight than outbred wildtype controls, but this effect was not observed for female individuals. To explore the possible reasons for the observed gender-specific growth arrest, we determined the basic hematological parameters and found that aged male Alox15b-KI mice exhibited significantly attenuated red blood cell parameters (erythrocyte counts, hematocrit, hemoglobin). Here again, these differences were not observed in female individuals. These data suggest that humanization of the reaction specificity of mouse Alox15b impairs the functionality of the hematopoietic system in males, which is paralleled by a premature growth arrest.}, language = {en} } @article{Kuehn2007, author = {K{\"u}hn, Florian P.}, title = {Mehr Politik!}, series = {WeltTrends-Papiere}, journal = {WeltTrends-Papiere}, number = {5}, issn = {1864-0656}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-31761}, pages = {41 -- 46}, year = {2007}, abstract = {Inhalt: - Welche Staatlichkeit? - Gewalt folgt einer eigenen Logik - Beispiel Afghanistan - Mehr Sicherheit? F{\"u}r wen? - Risiko ist keine Bedrohung - Nassauer hat Recht und zugleich Unrecht}, language = {de} } @book{SchroederSchellhardtAkincietal.2015, author = {Schroeder, Christoph and Schellhardt, Christin and Akinci, Mehmet-Ali and Dollnick, Meral and Dux, Ginesa and G{\"u}lbeyaz, Esin I{\c{s}}{\i}l and J{\"a}hnert, Anne and Ko{\c{c}}-G{\"u}lt{\"u}rk, Ceren and K{\"u}hmstedt, Patrick and Kuhn, Florian and Mezger, Verena and Pfaff, Carol and {\"U}rkmez, Bet{\"u}l Sena}, title = {MULTILIT}, editor = {Schroeder, Christoph and Schellhardt, Christin}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-80390}, publisher = {Universit{\"a}t Potsdam}, year = {2015}, abstract = {This paper presents an overview of the linguistic analyses developed in the MULTILIT project and the processing of the oral and written texts collected. The project investigates the language abilities of multilingual children and adolescents, in particular, those who have Turkish and/or Kurdish as a mother tongue. A further aim of the project is to examine from a psycholinguistic and sociolinguistic perspective the extent to which competence in academic registers is achieved on the basis of the languages spoken by the children, including the language(s) spoken at the home, the language of the country of residence and the first foreign language. To be able to examine these questions using corpus linguistic parameters, we created categories of analysis in MULTILIT. The data collection comprises texts from bilingual and monolingual children and adolescents in Germany in their first language Turkish, their second language German und their foreign language English. Pupils aged between nine and twenty years of age produced monologue oral and written texts in the two genres of narrative and discursive. On the basis of these samples, we examine linguistic features such as lexical expression (lexical density, lexical diversity), syntactic complexity (syntactic and discursive packaging) as well as phonology in the oral texts and orthography in the written texts, with the aim of investigating the pupils' growing mastery of these features in academic and informal registers. To this end the raw data have been transcribed by the use of transcription conventions developed especially for the needs of the MULTILIT data. They are based on the commonly used HIAT and GAT transcription conventions and supplemented with conventions that provide additional information such as features at the graphic level. The categories of analysis comprise a large number of linguistic categories such as word classes, syntax, noun phrase complexity, complex verbal morphology, direct speech and text structures. We also annotate errors and norm deviations at a wide range of levels (orthographic, morphological, lexical, syntactic and textual). In view of the different language systems, these criteria are considered separately for all languages investigated in the project.}, language = {en} }