@article{AartsAndersonAndersonetal.2015,
  author    = {Aarts, Alexander A. and Anderson, Joanna E. and Anderson, Christopher J. and Attridge, Peter R. and Attwood, Angela and Axt, Jordan and Babel, Molly and Bahnik, Stepan and Baranski, Erica and Barnett-Cowan, Michael and Bartmess, Elizabeth and Beer, Jennifer and Bell, Raoul and Bentley, Heather and Beyan, Leah and Binion, Grace and Borsboom, Denny and Bosch, Annick and Bosco, Frank A. and Bowman, Sara D. and Brandt, Mark J. and Braswell, Erin and Brohmer, Hilmar and Brown, Benjamin T. and Brown, Kristina and Bruening, Jovita and Calhoun-Sauls, Ann and Callahan, Shannon P. and Chagnon, Elizabeth and Chandler, Jesse and Chartier, Christopher R. and Cheung, Felix and Christopherson, Cody D. and Cillessen, Linda and Clay, Russ and Cleary, Hayley and Cloud, Mark D. and Cohn, Michael and Cohoon, Johanna and Columbus, Simon and Cordes, Andreas and Costantini, Giulio and Alvarez, Leslie D. Cramblet and Cremata, Ed and Crusius, Jan and DeCoster, Jamie and DeGaetano, Michelle A. and Della Penna, Nicolas and den Bezemer, Bobby and Deserno, Marie K. and Devitt, Olivia and Dewitte, Laura and Dobolyi, David G. and Dodson, Geneva T. and Donnellan, M. Brent and Donohue, Ryan and Dore, Rebecca A. and Dorrough, Angela and Dreber, Anna and Dugas, Michelle and Dunn, Elizabeth W. and Easey, Kayleigh and Eboigbe, Sylvia and Eggleston, Casey and Embley, Jo and Epskamp, Sacha and Errington, Timothy M. and Estel, Vivien and Farach, Frank J. and Feather, Jenelle and Fedor, Anna and Fernandez-Castilla, Belen and Fiedler, Susann and Field, James G. and Fitneva, Stanka A. and Flagan, Taru and Forest, Amanda L. and Forsell, Eskil and Foster, Joshua D. and Frank, Michael C. and Frazier, Rebecca S. and Fuchs, Heather and Gable, Philip and Galak, Jeff and Galliani, Elisa Maria and Gampa, Anup and Garcia, Sara and Gazarian, Douglas and Gilbert, Elizabeth and Giner-Sorolla, Roger and Gl{\"o}ckner, Andreas and G{\"o}llner, Lars and Goh, Jin X. and Goldberg, Rebecca and Goodbourn, Patrick T. and Gordon-McKeon, Shauna and Gorges, Bryan and Gorges, Jessie and Goss, Justin and Graham, Jesse and Grange, James A. and Gray, Jeremy and Hartgerink, Chris and Hartshorne, Joshua and Hasselman, Fred and Hayes, Timothy and Heikensten, Emma and Henninger, Felix and Hodsoll, John and Holubar, Taylor and Hoogendoorn, Gea and Humphries, Denise J. and Hung, Cathy O. -Y. and Immelman, Nathali and Irsik, Vanessa C. and Jahn, Georg and Jaekel, Frank and Jekel, Marc and Johannesson, Magnus and Johnson, Larissa G. and Johnson, David J. and Johnson, Kate M. and Johnston, William J. and Jonas, Kai and Joy-Gaba, Jennifer A. and Kappes, Heather Barry and Kelso, Kim and Kidwell, Mallory C. and Kim, Seung Kyung and Kirkhart, Matthew and Kleinberg, Bennett and Knezevic, Goran and Kolorz, Franziska Maria and Kossakowski, Jolanda J. and Krause, Robert Wilhelm and Krijnen, Job and Kuhlmann, Tim and Kunkels, Yoram K. and Kyc, Megan M. and Lai, Calvin K. and Laique, Aamir and Lakens, Daniel and Lane, Kristin A. and Lassetter, Bethany and Lazarevic, Ljiljana B. and LeBel, Etienne P. and Lee, Key Jung and Lee, Minha and Lemm, Kristi and Levitan, Carmel A. and Lewis, Melissa and Lin, Lin and Lin, Stephanie and Lippold, Matthias and Loureiro, Darren and Luteijn, Ilse and Mackinnon, Sean and Mainard, Heather N. and Marigold, Denise C. and Martin, Daniel P. and Martinez, Tylar and Masicampo, E. J. and Matacotta, Josh and Mathur, Maya and May, Michael and Mechin, Nicole and Mehta, Pranjal and Meixner, Johannes and Melinger, Alissa and Miller, Jeremy K. and Miller, Mallorie and Moore, Katherine and M{\"o}schl, Marcus and Motyl, Matt and M{\"u}ller, Stephanie M. and Munafo, Marcus and Neijenhuijs, Koen I. and Nervi, Taylor and Nicolas, Gandalf and Nilsonne, Gustav and Nosek, Brian A. and Nuijten, Michele B. and Olsson, Catherine and Osborne, Colleen and Ostkamp, Lutz and Pavel, Misha and Penton-Voak, Ian S. and Perna, Olivia and Pernet, Cyril and Perugini, Marco and Pipitone, R. Nathan and Pitts, Michael and Plessow, Franziska and Prenoveau, Jason M. and Rahal, Rima-Maria and Ratliff, Kate A. and Reinhard, David and Renkewitz, Frank and Ricker, Ashley A. and Rigney, Anastasia and Rivers, Andrew M. and Roebke, Mark and Rutchick, Abraham M. and Ryan, Robert S. and Sahin, Onur and Saide, Anondah and Sandstrom, Gillian M. and Santos, David and Saxe, Rebecca and Schlegelmilch, Rene and Schmidt, Kathleen and Scholz, Sabine and Seibel, Larissa and Selterman, Dylan Faulkner and Shaki, Samuel and Simpson, William B. and Sinclair, H. Colleen and Skorinko, Jeanine L. M. and Slowik, Agnieszka and Snyder, Joel S. and Soderberg, Courtney and Sonnleitner, Carina and Spencer, Nick and Spies, Jeffrey R. and Steegen, Sara and Stieger, Stefan and Strohminger, Nina and Sullivan, Gavin B. and Talhelm, Thomas and Tapia, Megan and te Dorsthorst, Anniek and Thomae, Manuela and Thomas, Sarah L. and Tio, Pia and Traets, Frits and Tsang, Steve and Tuerlinckx, Francis and Turchan, Paul and Valasek, Milan and Van Aert, Robbie and van Assen, Marcel and van Bork, Riet and van de Ven, Mathijs and van den Bergh, Don and van der Hulst, Marije and van Dooren, Roel and van Doorn, Johnny and van Renswoude, Daan R. and van Rijn, Hedderik and Vanpaemel, Wolf and Echeverria, Alejandro Vasquez and Vazquez, Melissa and Velez, Natalia and Vermue, Marieke and Verschoor, Mark and Vianello, Michelangelo and Voracek, Martin and Vuu, Gina and Wagenmakers, Eric-Jan and Weerdmeester, Joanneke and Welsh, Ashlee and Westgate, Erin C. and Wissink, Joeri and Wood, Michael and Woods, Andy and Wright, Emily and Wu, Sining and Zeelenberg, Marcel and Zuni, Kellylynn},
  title     = {Estimating the reproducibility of psychological science},
  series = {Science},
  volume    = {349},
  journal   = {Science},
  number    = {6251},
  publisher = {American Assoc. for the Advancement of Science},
  address   = {Washington},
  organization    = {Open Sci Collaboration},
  issn      = {1095-9203},
  doi       = {10.1126/science.aac4716},
  pages     = {8},
  year      = {2015},
  abstract  = {Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47\% of original effect sizes were in the 95\% confidence interval of the replication effect size; 39\% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68\% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.},
  language  = {en}
}
@article{AbdallaAdamAharonianetal.2020,
  author    = {Abdalla, H. and Adam, R. and Aharonian, Felix A. and Benkhali, F. Ait and Ang{\"u}ner, Ekrem Oǧuzhan and Arcaro, C. and Armand, C. and Armstrong, T. and Ashkar, H. and Backes, M. and Baghmanyan, V. and Martins, V. Barbosa and Barnacka, A. and Barnard, M. and Becherini, Y. and Berge, D. and Bernlohr, K. and Bi, B. and Bottcher, M. and Boisson, C. and Bolmont, J. and de Lavergne, M. de Bony and Bordas, Pol and Breuhaus, M. and Brun, F. and Brun, P. and Bryan, M. and Buchele, M. and Bulik, T. and Bylund, T. and Caroff, S. and Carosi, A. and Casanova, Sabrina and Chand, T. and Chandra, S. and Chen, A. and Cotter, G. and Curylo, M. and Mbarubucyeye, J. Damascene and Davids, I. D. and Davies, J. and Deil, C. and Devin, J. and deWilt, P. and Dirson, L. and Djannati-Atai, A. and Dmytriiev, A. and Donath, A. and Doroshenko, V. and Duffy, C. and Dyks, J. and Egberts, Kathrin and Eichhorn, F. and Einecke, S. and Emery, G. and Ernenwein, J. -P. and Feijen, K. and Fegan, S. and Fiasson, A. and de Clairfontaine, G. Fichet and Fontaine, G. and Funk, S. and Fussling, Matthias and Gabici, S. and Gallant, Y. A. and Giavitto, G. and Giunti, L. and Glawion, D. and Glicenstein, J. F. and Gottschall, D. and Grondin, M. -H. and Hahn, J. and Haupt, M. and Hermann, G. and Hinton, J. A. and Hofmann, W. and Hoischen, Clemens and Holch, T. L. and Holler, M. and Horbe, M. and Horns, D. and Huber, D. and Jamrozy, M. and Jankowsky, D. and Jankowsky, F. and Jardin-Blicq, A. and Joshi, V. and Jung-Richardt, I. and Kasai, E. and Kastendieck, M. A. and Katarzynski, K. and Katz, U. and Khangulyan, D. and Khelifi, B. and Klepser, S. and Kluzniak, W. and Komin, Nu. and Konno, R. and Kosack, K. and Kostunin, D. and Kreter, M. and Lamanna, G. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J. -P. and Levy, C. and Lohse, T. and Lypova, I. and Mackey, J. and Majumdar, J. and Malyshev, D. and Malyshev, D. and Marandon, V. and Marchegiani, P. and Marcowith, Alexandre and Mares, A. and Marti-Devesa, G. and Marx, R. and Maurin, G. and Meintjes, P. J. and Meyer, M. and Mitchell, A. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Montanari, A. and Moore, C. and Morris, P. and Moulin, Emmanuel and Muller, J. and Murach, T. and Nakashima, K. and Nayerhoda, A. and de Naurois, M. and Ndiyavala, H. and Niederwanger, F. and Niemiec, J. and Oakes, L. and O'Brien, Patrick and Odaka, H. and Ohm, S. and Olivera-Nieto, L. and Wilhelmi, E. de Ona and Ostrowski, M. and Oya, I. and Panter, M. and Panny, S. and Parsons, R. D. and Peron, G. and Peyaud, B. and Piel, Q. and Pita, S. and Poireau, V. and Noel, A. Priyana and Prokhorov, D. A. and Prokoph, H. and Puhlhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Rauth, R. and Reichherzer, P. and Reimer, A. and Reimer, O. and Remy, Q. and Renaud, M. and Rieger, F. and Rinchiuso, L. and Romoli, C. and Rowell, G. and Rudak, B. and Ruiz-Velasco, E. and Sahakian, V. and Sailer, S. and Sanchez, D. A. and Santangelo, Andrea and Sasaki, M. and Scalici, M. and Schussler, F. and Schutte, H. M. and Schwanke, U. and Schwemmer, S. and Seglar-Arroyo, M. and Senniappan, M. and Seyffert, A. S. and Shafi, N. and Shiningayamwe, K. and Simoni, R. and Sinha, A. and Sol, H. and Specovius, A. and Spencer, S. and Spir-Jacob, M. and Stawarz, L. and Sun, L. and Steenkamp, R. and Stegmann, C. and Steinmassl, S. and Steppa, C. and Takahashi, T. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tiziani, D. and Tluczykont, M. and Tomankova, L. and Trichard, C. and Tsirou, M. and Tuffs, R. and Uchiyama, Y. and van der Walt, D. J. and van Eldik, C. and van Rensburg, C. and van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Vincent, P. and Vink, J. and Volk, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and Watson, J. and Werner, F. and White, R. and Wierzcholska, A. and Wong, Yu Wun and Yusafzai, A. and Zacharias, M. and Zanin, R. and Zargaryan, D. and Zdziarski, A. A. and Zech, Alraune and Zhu, S. J. and Ziegler, A. and Zorn, J. and Zouari, S. and Zywucka, N.},
  title     = {An extreme particle accelerator in the Galactic plane},
  series = {Astronomy and astrophysics : an international weekly journal},
  volume    = {644},
  journal   = {Astronomy and astrophysics : an international weekly journal},
  publisher = {EDP Sciences},
  address   = {Les Ulis},
  organization    = {HESS Collaboration},
  issn      = {0004-6361},
  doi       = {10.1051/0004-6361/202038851},
  pages     = {8},
  year      = {2020},
  abstract  = {The unidentified very-high-energy (VHE; E > 0.1 TeV) gamma -ray source, HESS J1826-130, was discovered with the High Energy Stereoscopic System (HESS) in the Galactic plane. The analysis of 215 h of HESS data has revealed a steady gamma -ray flux from HESS J1826-130, which appears extended with a half-width of 0.21 degrees +/- 0.02 <br /> (stat)degrees <br /> stat degrees +/- 0.05 <br /> (sys)degrees sys degrees . The source spectrum is best fit with either a power-law function with a spectral index Gamma = 1.78 +/- 0.10(stat) +/- 0.20(sys) and an exponential cut-off at 15.2 <br /> (+5.5)(-3.2) -3.2+5.5 TeV, or a broken power-law with Gamma (1) = 1.96 +/- 0.06(stat) +/- 0.20(sys), Gamma (2) = 3.59 +/- 0.69(stat) +/- 0.20(sys) for energies below and above E-br = 11.2 +/- 2.7 TeV, respectively. The VHE flux from HESS J1826-130 is contaminated by the extended emission of the bright, nearby pulsar wind nebula, HESS J1825-137, particularly at the low end of the energy spectrum. Leptonic scenarios for the origin of HESS J1826-130 VHE emission related to PSR J1826-1256 are confronted by our spectral and morphological analysis. In a hadronic framework, taking into account the properties of dense gas regions surrounding HESS J1826-130, the source spectrum would imply an astrophysical object capable of accelerating the parent particle population up to greater than or similar to 200 TeV. Our results are also discussed in a multiwavelength context, accounting for both the presence of nearby supernova remnants, molecular clouds, and counterparts detected in radio, X-rays, and TeV energies.},
  language  = {en}
}
@article{AbdallaAdamAharonianetal.2019,
  author    = {Abdalla, Hassan E. and Adam, R. and Aharonian, Felix A. and Benkhali, F. Ait and Ang{\"u}ner, Ekrem Oǧuzhan and Arakawa, M. and Arcaro, C. and Armand, C. and Ashkar, H. and Backes, M. and Martins, V. Barbosa and Barnard, M. and Becherini, Y. and Berge, D. and Bernloehr, K. and Bissaldi, E. and Blackwell, R. and Boettcher, M. and Boisson, C. and Bolmont, J. and Bonnefoy, S. and Bregeon, J. and Breuhaus, M. and Brun, F. and Brun, P. and Bryan, M. and Buechele, M. and Bulik, T. and Bylund, T. and Capasso, M. and Caroff, S. and Carosi, A. and Casanova, Sabrina and Cerruti, M. and Chand, T. and Chandra, S. and Chen, A. and Colafrancesco, S. and Curylo, M. and Davids, I. D. and Deil, C. and Devin, J. and deWilt, P. and Dirson, L. and Djannati-Atai, A. and Dmytriiev, A. and Donath, A. and Doroshenko, V and Dyks, J. and Egberts, Kathrin and Emery, G. and Ernenwein, J-P and Eschbach, S. and Feijen, K. and Fegan, S. and Fiasson, A. and Fontaine, G. and Funk, S. and Fussling, Matthias and Gabici, S. and Gallant, Y. A. and Gate, F. and Giavitto, G. and Giunti, L. and Glawion, D. and Glicenstein, J. F. and Gottschall, D. and Grondin, M-H and Hahn, J. and Haupt, M. and Heinzelmann, G. and Henri, G. and Hermann, G. and Hinton, J. A. and Hofmann, W. and Hoischen, Clemens and Holch, T. L. and Holler, M. and Horns, D. and Huber, D. and Iwasaki, H. and Jamrozy, M. and Jankowsky, D. and Jankowsky, F. and Jardin-Blicq, A. and Jung-Richardt, I and Kastendieck, M. A. and Katarzynski, K. and Katsuragawa, M. and Katz, U. and Khangulyan, D. and Khelifi, B. and King, J. and Klepser, S. and Kluzniak, W. and Komin, Nu and Kosack, K. and Kostunin, D. and Kreter, M. and Lamanna, G. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J-P and Leser, Eva and Levy, C. and Lohse, T. and Lypova, I and Mackey, J. and Majumdar, J. and Malyshev, D. and Marandon, V and Marcowith, Alexandre and Mares, A. and Mariaud, C. and Marti-Devesa, G. and Marx, R. and Maurin, G. and Meintjes, P. J. and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Moore, C. and Moulin, Emmanuel and Muller, J. and Murach, T. and Nakashima, S. and de Naurois, M. and Ndiyavala, H. and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, H. and Ohm, S. and Wilhelmi, E. de Ona and Ostrowski, M. and Oya, I and Panter, M. and Parsons, R. D. and Perennes, C. and Petrucci, P-O and Peyaud, B. and Piel, Q. and Pita, S. and Poireau, V and Noel, A. Priyana and Prokhorov, D. A. and Prokoph, H. and Puehlhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Rauth, R. and Reimer, A. and Reimer, O. and Remy, Q. and Renaud, M. and Rieger, F. and Rinchiuso, L. and Romoli, C. and Rowell, G. and Rudak, B. and Ruiz-Velasco, E. and Sahakian, V and Sailer, S. and Saito, S. and Sanchez, D. A. and Santangelo, Andrea and Sasaki, M. and Schlickeiser, R. and Schussler, F. and Schulz, A. and Schutte, H. M. and Schwanke, U. and Schwemmer, S. and Seglar-Arroyo, M. and Senniappan, M. and Seyffert, A. S. and Shafi, N. and Shiningayamwe, K. and Simoni, R. and Sinha, A. and Sol, H. and Specovius, A. and Spir-Jacob, M. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steppa, Constantin Beverly and Takahashi, T. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tiziani, D. and Tluczykont, M. and Trichard, C. and Tsirou, M. and Tsuji, N. and Tuffs, R. and Uchiyama, Y. and van der Walt, D. J. and van Eldik, C. and van Rensburg, C. and van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Vincent, P. and Vink, J. and Voelk, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and White, R. and Wierzcholska, A. and Yang, R. and Yoneda, H. and Zacharias, M. and Zanin, R. and Zdziarski, A. A. and Zech, Alraune and Ziegler, A. and Zorn, J. and Zywucka, N. and de Palma, F. and Axelsson, M. and Roberts, O. J.},
  title     = {A very-high-energy component deep in the gamma-ray burst afterglow},
  series = {Nature : the international weekly journal of science},
  volume    = {575},
  journal   = {Nature : the international weekly journal of science},
  number    = {7783},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {0028-0836},
  doi       = {10.1038/s41586-019-1743-9},
  pages     = {464 -- +},
  year      = {2019},
  abstract  = {Gamma-ray bursts (GRBs) are brief flashes of gamma-rays and are considered to be the most energetic explosive phenomena in the Universe(1). The emission from GRBs comprises a short (typically tens of seconds) and bright prompt emission, followed by a much longer afterglow phase. During the afterglow phase, the shocked outflow-produced by the interaction between the ejected matter and the circumburst medium-slows down, and a gradual decrease in brightness is observed(2). GRBs typically emit most of their energy via.-rays with energies in the kiloelectronvolt-to-megaelectronvolt range, but a few photons with energies of tens of gigaelectronvolts have been detected by space-based instruments(3). However, the origins of such high-energy (above one gigaelectronvolt) photons and the presence of very-high-energy (more than 100 gigaelectronvolts) emission have remained elusive(4). Here we report observations of very-high-energy emission in the bright GRB 180720B deep in the GRB afterglow-ten hours after the end of the prompt emission phase, when the X-ray flux had already decayed by four orders of magnitude. Two possible explanations exist for the observed radiation: inverse Compton emission and synchrotron emission of ultrarelativistic electrons. Our observations show that the energy fluxes in the X-ray and gamma-ray range and their photon indices remain comparable to each other throughout the afterglow. This discovery places distinct constraints on the GRB environment for both emission mechanisms, with the inverse Compton explanation alleviating the particle energy requirements for the emission observed at late times. The late timing of this detection has consequences for the future observations of GRBs at the highest energies.},
  language  = {en}
}
@article{AbdallaAdamAharonianetal.2019,
  author    = {Abdalla, Hassan E. and Adam, R. and Aharonian, Felix A. and Benkhali, F. Ait and Ang{\"u}ner, Ekrem Oǧuzhan and Arakawa, M. and Arcaro, C. and Armand, C. and Ashkar, H. and Backes, M. and Martins, V. Barbosa and Barnard, M. and Becherini, Y. and Berge, D. and Bernloehr, K. and Blackwell, R. and B{\"o}ttcher, M. and Boisson, C. and Bolmont, J. and Bonnefoy, S. and Bregeon, J. and Breuhaus, M. and Brun, F. and Brun, P. and Bryan, M. and B{\"u}chele, M. and Bulik, T. and Bylund, T. and Capasso, M. and Caroff, S. and Carosi, A. and Casanova, Sabrina and Cerruti, M. and Chand, T. and Chandra, S. and Chen, A. and Colafrancesco, S. and Curylo, M. and Davids, I. D. and Deil, C. and Devin, J. and DeWilt, P. and Dirson, L. and Djannati-Ata, A. and Dmytriiev, A. and Donath, A. and Doroshenko, V and Dyks, J. and Egberts, Kathrin and Emery, G. and Ernenwein, J-P and Eschbach, S. and Feijen, K. and Fegan, S. and Fiasson, A. and Fontaine, G. and Funk, S. and F{\"u}ßling, Matthias and Gabici, S. and Gallant, Y. A. and Gate, F. and Giavitto, G. and Glawion, D. and Glicenstein, J. F. and Gottschall, D. and Grondin, M-H and Hahn, J. and Haupt, M. and Heinzelmann, G. and Henri, G. and Hermann, G. and Hinton, James Anthony and Hofmann, W. and Hoischen, Clemens and Holch, Tim Lukas and Holler, M. and Horns, D. and Huber, D. and Iwasaki, H. and Jamrozy, M. and Jankowsky, D. and Jankowsky, F. and Jardin-Blicq, A. and Jung-Richardt, I and Kastendieck, M. A. and Katarzynski, K. and Katsuragawa, M. and Katz, U. and Khangulyan, D. and Khelifi, B. and King, J. and Klepser, S. and Kluzniak, W. and Komin, Nu and Kosack, K. and Kostunin, D. and Kraus, M. and Lamanna, G. and Lau, J. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J-P and Leser, Eva and Levy, C. and Lohse, T. and Lypova, I and Mackey, J. and Majumdar, J. and Malyshev, D. and Marandon, V and Marcowith, Alexandre and Mares, A. and Mariaud, C. and Marti-Devesa, G. and Marx, R. and Maurin, G. and Meintjes, P. J. and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Moore, C. and Moulin, Emmanuel and Muller, J. and Murach, T. and Nakashima, S. and de Naurois, M. and Ndiyavala, H. and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, H. and Ohm, S. and Wilhelmi, E. de Ona and Ostrowski, M. and Oya, I and Panter, M. and Parsons, R. D. and Perennes, C. and Petrucci, P-O and Peyaud, B. and Piel, Q. and Pita, S. and Poireau, V and Priyana Noel, A. and Prokhorov, D. A. and Prokoph, H. and P{\"u}hlhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Rauth, R. and Reimer, A. and Reimer, O. and Remy, Q. and Renaud, M. and Rieger, F. and Rinchiuso, L. and Romoli, C. and Rowell, G. and Rudak, B. and Ruiz-Velasco, E. and Sahakian, V and Saito, S. and Sanchez, David M. and Santangelo, Andrea and Sasaki, M. and Schlickeiser, R. and Sch{\"u}ssler, F. and Schulz, A. and Schutte, H. and Schwanke, U. and Schwemmer, S. and Seglar-Arroyo, M. and Senniappan, M. and Seyffert, A. S. and Shafi, N. and Shiningayamwe, K. and Simoni, R. and Sinha, A. and Sol, H. and Specovius, A. and Spir-Jacob, M. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steppa, Constantin Beverly and Takahashi, T. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tiziani, D. and Tluczykont, M. and Trichard, C. and Tsirou, M. and Tsuji, N. and Tuffs, R. and Uchiyama, Y. and van Der Walt, D. J. and van Eldik, C. and van Rensburg, C. and van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Vincent, P. and Vink, J. and Voisin, F. and Voelk, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and White, R. and Wierzcholska, A. and Yang, R. and Yoneda, H. and Zacharias, Michael and Zanin, R. and Zdziarski, A. A. and Zech, Alraune and Ziegler, A. and Zorn, J. and Zywucka, N. and Meyer, M.},
  title     = {Constraints on the emission region of 3C 279 during strong flares in 2014 and 2015 through VHE gamma-ray observations with HESS},
  series = {Astronomy and astrophysics : an international weekly journal},
  volume    = {627},
  journal   = {Astronomy and astrophysics : an international weekly journal},
  publisher = {EDP Sciences},
  address   = {Les Ulis},
  organization    = {HESS Collaboration},
  issn      = {1432-0746},
  doi       = {10.1051/0004-6361/201935704},
  pages     = {19},
  year      = {2019},
  abstract  = {The flat spectrum radio quasar 3C 279 is known to exhibit pronounced variability in the high-energy (100MeV < E < 100 GeV) gamma-ray band, which is continuously monitored with Fermi-LAT. During two periods of high activity in April 2014 and June 2015 target-of-opportunity observations were undertaken with the High Energy Stereoscopic System (H.E.S.S.) in the very-high-energy (VHE, E > 100 GeV) gamma-ray domain. While the observation in 2014 provides an upper limit, the observation in 2015 results in a signal with 8 : 7 sigma significance above an energy threshold of 66 GeV. No VHE variability was detected during the 2015 observations. The VHE photon spectrum is soft and described by a power-law index of 4.2 +/- 0.3. The H.E.S.S. data along with a detailed and contemporaneous multiwavelength data set provide constraints on the physical parameters of the emission region. The minimum distance of the emission region from the central black hole was estimated using two plausible geometries of the broad-line region and three potential intrinsic spectra. The emission region is confidently placed at r greater than or similar to 1 : 7 X 1017 cm from the black hole, that is beyond the assumed distance of the broad-line region. Time-dependent leptonic and lepto-hadronic one-zone models were used to describe the evolution of the 2015 flare. Neither model can fully reproduce the observations, despite testing various parameter sets. Furthermore, the H.E.S.S. data were used to derive constraints on Lorentz invariance violation given the large redshift of 3C 279.},
  language  = {en}
}
@article{AbdallaAharonianBenkhalietal.2019,
  author    = {Abdalla, Hassan E. and Aharonian, Felix A. and Benkhali, F. Ait and Anguener, E. O. and Arakawa, M. and Arcaro, C. and Armand, C. and Ashkar, H. and Backes, M. and Martins, V. Barbosa and Barnard, M. and Becherini, Y. and Berge, D. and Bernloehr, K. and Blackwell, R. and Boettcher, M. and Boisson, C. and Bolmont, J. and Bonnefoy, S. and Bregeon, J. and Breuhaus, M. and Brun, F. and Brun, P. and Bryan, M. and Buechele, M. and Bulik, T. and Bylund, T. and Capasso, M. and Caroff, S. and Carosi, A. and Casanova, Sabrina and Cerruti, M. and Chakraborty, N. and Chand, T. and Chandra, S. and Chaves, R. C. G. and Chen, A. and Colafrancesco, S. and Curylo, M. and Davids, I. D. and Deil, C. and Devin, J. and de Wilt, P. and Dirson, L. and Djannati-Atai, A. and Dmytriiev, A. and Donath, A. and Doroshenko, V and Dyks, J. and Egberts, Kathrin and Emery, G. and Ernenwein, J-p and Eschbach, S. and Feijen, K. and Fegan, S. and Fiasson, A. and Fontaine, G. and Funk, S. and Fuessling, M. and Gabici, S. and Gallant, Y. A. and Gate, F. and Giavitto, G. and Glawion, D. and Glicenstein, J. F. and Gottschall, D. and Grondin, M-H and Hahn, J. and Haupt, M. and Heinzelmann, G. and Henri, G. and Hermann, G. and Hinton, James Anthony and Hofmann, W. and Hoischen, Clemens and Holch, Tim Lukas and Holler, M. and Horns, D. and Huber, D. and Iwasaki, H. and Jamrozy, M. and Jankowsky, D. and Jankowsky, F. and Jung-Richardt, I and Kastendieck, M. A. and Katarzynski, K. and Katsuragawa, M. and Katz, U. and Khangulyan, D. and Khelifi, B. and King, J. and Klepser, S. and Kluzniak, W. and Komin, Nu and Kosack, K. and Kostunin, D. and Kraus, M. and Lamanna, G. and Lau, J. and Lemiere, A. and Lemoine-Goumard, M. and Lenain, J-P and Leser, Eva and Levy, C. and Lohse, T. and Lopez-Coto, R. and Lypova, I and Mackey, J. and Majumdar, J. and Malyshev, D. and Marandon, V and Marcowith, Alexandre and Mares, A. and Mariaud, C. and Marti-Devesa, G. and Marx, R. and Maurin, G. and Meintjes, P. J. and Mitchell, A. M. W. and Moderski, R. and Mohamed, M. and Mohrmann, L. and Muller, J. and Moore, C. and Moulin, Emmanuel and Murach, T. and Nakashima, S. and de Naurois, M. and Ndiyavala, H. and Niederwanger, F. and Niemiec, J. and Oakes, L. and Odaka, H. and Ohm, S. and Wilhelmi, E. de Ona and Ostrowski, M. and Oya, I and Panter, M. and Parsons, R. D. and Perennes, C. and Petrucci, P-O and Peyaud, B. and Piel, Q. and Pita, S. and Poireau, V and Noel, A. Priyana and Prokhorov, D. A. and Prokoph, H. and Puehlhofer, G. and Punch, M. and Quirrenbach, A. and Raab, S. and Rauth, R. and Reimer, A. and Reimer, O. and Remy, Q. and Renaud, M. and Rieger, F. and Rinchiuso, L. and Romoli, C. and Rowell, G. and Rudak, B. and Ruiz-Velasco, E. and Sahakian, V and Saito, S. and Sanchez, David M. and Santangelo, Andrea and Sasaki, M. and Schlickeiser, R. and Schussler, F. and Schulz, A. and Schutte, H. and Schwanke, U. and Schwemmer, S. and Seglar-Arroyo, M. and Senniappan, M. and Seyffert, A. S. and Shafi, N. and Shiningayamwe, K. and Simoni, R. and Sinha, A. and Sol, H. and Specovius, A. and Spir-Jacob, M. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steppa, Constantin Beverly and Takahashi, T. and Tavernier, T. and Taylor, A. M. and Terrier, R. and Tiziani, D. and Tluczykont, M. and Trichard, C. and Tsirou, M. and Tsuji, N. and Tuffs, R. and Uchiyama, Y. and van der Walt, D. J. and van Eldik, C. and van Rensburg, C. and van Soelen, B. and Vasileiadis, G. and Veh, J. and Venter, C. and Vincent, P. and Vink, J. and Voisin, F. and Voelk, H. J. and Vuillaume, T. and Wadiasingh, Z. and Wagner, S. J. and White, R. and Wierzcholska, A. and Yang, R. and Yoneda, H. and Zacharias, M. and Zanin, R. and Zdziarski, A. A. and Zech, Alraune and Ziegler, A. and Zorn, J. and Zywucka, N. and Maxted, N.},
  title     = {Upper limits on very-high-energy gamma-ray emission from core-collapse supernovae observed with H.E.S.S.},
  series = {Astronomy and astrophysics : an international weekly journal},
  volume    = {626},
  journal   = {Astronomy and astrophysics : an international weekly journal},
  publisher = {EDP Sciences},
  address   = {Les Ulis},
  organization    = {HESS Collaboration},
  issn      = {1432-0746},
  doi       = {10.1051/0004-6361/201935242},
  pages     = {11},
  year      = {2019},
  abstract  = {Young core-collapse supernovae with dense-wind progenitors may be able to accelerate cosmic-ray hadrons beyond the knee of the cosmic-ray spectrum, and this may result in measurable gamma-ray emission. We searched for gamma-ray emission from ten super- novae observed with the High Energy Stereoscopic System (H.E.S.S.) within a year of the supernova event. Nine supernovae were observed serendipitously in the H.E.S.S. data collected between December 2003 and December 2014, with exposure times ranging from 1.4 to 53 h. In addition we observed SN 2016adj as a target of opportunity in February 2016 for 13 h. No significant gamma-ray emission has been detected for any of the objects, and upper limits on the >1 TeV gamma-ray flux of the order of similar to 10(-13) cm(-)(2)s(-1) are established, corresponding to upper limits on the luminosities in the range similar to 2 x 10(39) to similar to 1 x 10(42) erg s(-1). These values are used to place model-dependent constraints on the mass-loss rates of the progenitor stars, implying upper limits between similar to 2 x 10(-5) and similar to 2 x 10(-3) M-circle dot yr(-1) under reasonable assumptions on the particle acceleration parameters.},
  language  = {en}
}
@article{AllanBossdorfDormannetal.2014,
  author    = {Allan, Eric and Bossdorf, Oliver and Dormann, Carsten F. and Prati, Daniel and Gossner, Martin M. and Tscharntke, Teja and Bl{\"u}thgen, Nico and Bellach, Michaela and Birkhofer, Klaus and Boch, Steffen and B{\"o}hm, Stefan and B{\"o}rschig, Carmen and Chatzinotas, Antonis and Christ, Sabina and Daniel, Rolf and Diek{\"o}tter, Tim and Fischer, Christiane and Friedl, Thomas and Glaser, Karin and Hallmann, Christine and Hodac, Ladislav and H{\"o}lzel, Norbert and Jung, Kirsten and Klein, Alexandra-Maria and Klaus, Valentin H. and Kleinebecker, Till and Krauss, Jochen and Lange, Markus and Morris, E. Kathryn and M{\"u}ller, J{\"o}rg and Nacke, Heiko and Pasalic, Esther and Rillig, Matthias C. and Rothenwoehrer, Christoph and Schally, Peter and Scherber, Christoph and Schulze, Waltraud X. and Socher, Stephanie A. and Steckel, Juliane and Steffan-Dewenter, Ingolf and T{\"u}rke, Manfred and Weiner, Christiane N. and Werner, Michael and Westphal, Catrin and Wolters, Volkmar and Wubet, Tesfaye and Gockel, Sonja and Gorke, Martin and Hemp, Andreas and Renner, Swen C. and Sch{\"o}ning, Ingo and Pfeiffer, Simone and K{\"o}nig-Ries, Birgitta and Buscot, Francois and Linsenmair, Karl Eduard and Schulze, Ernst-Detlef and Weisser, Wolfgang W. and Fischer, Markus},
  title     = {Interannual variation in land-use intensity enhances grassland multidiversity},
  series = {Proceedings of the National Academy of Sciences of the United States of America},
  volume    = {111},
  journal   = {Proceedings of the National Academy of Sciences of the United States of America},
  number    = {1},
  publisher = {National Acad. of Sciences},
  address   = {Washington},
  issn      = {0027-8424},
  doi       = {10.1073/pnas.1312213111},
  pages     = {308 -- 313},
  year      = {2014},
  abstract  = {Although temporal heterogeneity is a well-accepted driver of biodiversity, effects of interannual variation in land-use intensity (LUI) have not been addressed yet. Additionally, responses to land use can differ greatly among different organisms; therefore, overall effects of land-use on total local biodiversity are hardly known. To test for effects of LUI (quantified as the combined intensity of fertilization, grazing, and mowing) and interannual variation in LUI (SD in LUI across time), we introduce a unique measure of whole-ecosystem biodiversity, multidiversity. This synthesizes individual diversity measures across up to 49 taxonomic groups of plants, animals, fungi, and bacteria from 150 grasslands. Multidiversity declined with increasing LUI among grasslands, particularly for rarer species and aboveground organisms, whereas common species and belowground groups were less sensitive. However, a high level of interannual variation in LUI increased overall multidiversity at low LUI and was even more beneficial for rarer species because it slowed the rate at which the multidiversity of rare species declined with increasing LUI. In more intensively managed grasslands, the diversity of rarer species was, on average, 18\% of the maximum diversity across all grasslands when LUI was static over time but increased to 31\% of the maximum when LUI changed maximally over time. In addition to decreasing overall LUI, we suggest varying LUI across years as a complementary strategy to promote biodiversity conservation.},
  language  = {en}
}
@article{BanksNishiyamaHasebeetal.2011,
  author    = {Banks, Jo Ann and Nishiyama, Tomoaki and Hasebe, Mitsuyasu and Bowman, John L. and Gribskov, Michael and dePamphilis, Claude and Albert, Victor A. and Aono, Naoki and Aoyama, Tsuyoshi and Ambrose, Barbara A. and Ashton, Neil W. and Axtell, Michael J. and Barker, Elizabeth and Barker, Michael S. and Bennetzen, Jeffrey L. and Bonawitz, Nicholas D. and Chapple, Clint and Cheng, Chaoyang and Correa, Luiz Gustavo Guedes and Dacre, Michael and DeBarry, Jeremy and Dreyer, Ingo and Elias, Marek and Engstrom, Eric M. and Estelle, Mark and Feng, Liang and Finet, Cedric and Floyd, Sandra K. and Frommer, Wolf B. and Fujita, Tomomichi and Gramzow, Lydia and Gutensohn, Michael and Harholt, Jesper and Hattori, Mitsuru and Heyl, Alexander and Hirai, Tadayoshi and Hiwatashi, Yuji and Ishikawa, Masaki and Iwata, Mineko and Karol, Kenneth G. and Koehler, Barbara and Kolukisaoglu, Uener and Kubo, Minoru and Kurata, Tetsuya and Lalonde, Sylvie and Li, Kejie and Li, Ying and Litt, Amy and Lyons, Eric and Manning, Gerard and Maruyama, Takeshi and Michael, Todd P. and Mikami, Koji and Miyazaki, Saori and Morinaga, Shin-ichi and Murata, Takashi and M{\"u}ller-R{\"o}ber, Bernd and Nelson, David R. and Obara, Mari and Oguri, Yasuko and Olmstead, Richard G. and Onodera, Naoko and Petersen, Bent Larsen and Pils, Birgit and Prigge, Michael and Rensing, Stefan A. and Mauricio Riano-Pachon, Diego and Roberts, Alison W. and Sato, Yoshikatsu and Scheller, Henrik Vibe and Schulz, Burkhard and Schulz, Christian and Shakirov, Eugene V. and Shibagaki, Nakako and Shinohara, Naoki and Shippen, Dorothy E. and Sorensen, Iben and Sotooka, Ryo and Sugimoto, Nagisa and Sugita, Mamoru and Sumikawa, Naomi and Tanurdzic, Milos and Theissen, Guenter and Ulvskov, Peter and Wakazuki, Sachiko and Weng, Jing-Ke and Willats, William W. G. T. and Wipf, Daniel and Wolf, Paul G. and Yang, Lixing and Zimmer, Andreas D. and Zhu, Qihui and Mitros, Therese and Hellsten, Uffe and Loque, Dominique and Otillar, Robert and Salamov, Asaf and Schmutz, Jeremy and Shapiro, Harris and Lindquist, Erika and Lucas, Susan and Rokhsar, Daniel and Grigoriev, Igor V.},
  title     = {The selaginella genome identifies genetic changes associated with the evolution of vascular plants},
  series = {Science},
  volume    = {332},
  journal   = {Science},
  number    = {6032},
  publisher = {American Assoc. for the Advancement of Science},
  address   = {Washington},
  issn      = {0036-8075},
  doi       = {10.1126/science.1203810},
  pages     = {960 -- 963},
  year      = {2011},
  abstract  = {Vascular plants appeared similar to 410 million years ago, then diverged into several lineages of which only two survive: the euphyllophytes (ferns and seed plants) and the lycophytes. We report here the genome sequence of the lycophyte Selaginella moellendorffii (Selaginella), the first nonseed vascular plant genome reported. By comparing gene content in evolutionarily diverse taxa, we found that the transition from a gametophyte- to a sporophyte-dominated life cycle required far fewer new genes than the transition from a nonseed vascular to a flowering plant, whereas secondary metabolic genes expanded extensively and in parallel in the lycophyte and angiosperm lineages. Selaginella differs in posttranscriptional gene regulation, including small RNA regulation of repetitive elements, an absence of the trans-acting small interfering RNA pathway, and extensive RNA editing of organellar genes.},
  language  = {en}
}
@article{BlasigWinklerLassowskietal.2006,
  author    = {Blasig, Ingolf E. and Winkler, Lars and Lassowski, Birgit and M{\"u}ller, Sandra L. and Zuleger, Nikolaj and Krause, Eberhard and Krause, Gerd and Gast, Klaus and Kolbe, Michael and Piontek, J{\"o}rg},
  title     = {On the self-association potential of transmembrane tight junction proteins},
  issn      = {1420-682X},
  doi       = {10.1007/s00018-005-5472-x},
  year      = {2006},
  abstract  = {Tight junctions seal intercellular clefts via membrane-related strands, hence, maintaining important organ functions. We investigated the self-association of strand-forming transmembrane tight junction proteins. The regulatory tight junction protein occludin was differently tagged and cotransfected in eucaryotic cells. These occludins colocalized within the plasma membrane of the same cell, coprecipitated and exhibited fluorescence resonance energy transfer. Differently tagged strand-forming claudin-5 also colocalized in the plasma membrane of the same cell and showed fluorescence resonance energy transfer. This demonstrates self-association in intact cells both of occludin and claudin-5 in one plasma membrane. In search of dimerizing regions of occludin, dimerization of its cytosolic C-terminal coiled-coil domain was identified. In claudin-5, the second extracellular loop was detected as a dimer. Since the transmembrane junctional adhesion molecule also is known to dimerize, the assumption that homodimerization of transmembrane tight junction proteins may serve as a common structural feature in tight junction assembly is supported},
  language  = {en}
}
@article{BringmannMutanyattaComarMaksimenkaetal.2008,
  author    = {Bringmann, Gerhard and Mutanyatta-Comar, Joan and Maksimenka, Katja and Wanjohi, John M. and Heydenreich, Matthias and Brun, Reto and M{\"u}ller, Werner E. G. and Peter, Martin G. and Midiwo, Jacob O. and Yenesew, Abiy},
  title     = {Joziknipholones A and B : the first dimeric phenylanthraquinones, from the roots of Bulbine frutescens},
  issn      = {0947-6539},
  year      = {2008},
  abstract  = {From the roots of the African plant Bulbine frutescens (Asphodelaceae), two unprecedented novel dimeric phenylanthraquinones, named joziknipholones A and B, possessing axial and centrochirality, were isolated, together with six known compounds. Structural elucidation of the new metabolites was achieved by spectroscopic and chiroptical methods, by reductive cleavage of the central bond between the monomeric phenylanthraquinone and -anthrone portions with sodium dithionite, and by quantum chemical CD calculations. Based on the recently revised absolute axial configuration of the parent phenylanthraquinones, knipholone and knipholone anthrone, the new dimers were attributed to possess the P- configuration (i.e., with the acetyl portions below the anthraquinone plane) at both axes in the case of joziknipholone A, whereas in joziknipholone B, the knipholone part was found to be M-configured. Joziknipholones A and B are active against the chloroquine resistant strain K1 of the malaria pathogen, Plasmodium falciparum, and show moderate activity against murine leukemic lymphoma L5178y cells.},
  language  = {en}
}
@article{BruneWilliamsMueller2018,
  author    = {Brune, Sascha and Williams, Simon E. and M{\"u}ller, R. Dietmar},
  title     = {Oblique rifting: the rule, not the exception},
  series = {Solid earth},
  volume    = {9},
  journal   = {Solid earth},
  number    = {5},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {1869-9510},
  doi       = {10.5194/se-9-1187-2018},
  pages     = {1187 -- 1206},
  year      = {2018},
  abstract  = {Movements of tectonic plates often induce oblique deformation at divergent plate boundaries. This is in striking contrast with traditional conceptual models of rifting and rifted margin formation, which often assume 2-D deformation where the rift velocity is oriented perpendicular to the plate boundary. Here we quantify the validity of this assumption by analysing the kinematics of major continent-scale rift systems in a global plate tectonic reconstruction from the onset of Pangea breakup until the present day. We evaluate rift obliquity by joint examination of relative extension velocity and local rift trend using the script-based plate reconstruction software pyGPlates. Our results show that the global mean rift obliquity since 230 Ma amounts to 34 degrees with a standard deviation of 24 degrees, using the convention that the angle of obliquity is spanned by extension direction and rift trend normal. We find that more than similar to 70 \% of all rift segments exceeded an obliquity of 20 degrees demonstrating that oblique rifting should be considered the rule, not the exception. In many cases, rift obliquity and extension velocity increase during rift evolution (e.g. Australia-Antarctica, Gulf of California, South Atlantic, India-Antarctica), which suggests an underlying geodynamic correlation via obliquity-dependent rift strength. Oblique rifting produces 3-D stress and strain fields that cannot be accounted for in simplified 2-D plane strain analysis. We therefore highlight the importance of 3-D approaches in modelling, surveying, and interpretation of most rift segments on Earth where oblique rifting is the dominant mode of deformation.},
  language  = {en}
}
@article{delValleMuellerRomero2018,
  author    = {del Valle, Maria Victoria and M{\"u}ller, A. L. and Romero, G. E.},
  title     = {High-energy radiation from collisions of high-velocity clouds and the Galactic disc},
  series = {Monthly notices of the Royal Astronomical Society},
  volume    = {475},
  journal   = {Monthly notices of the Royal Astronomical Society},
  number    = {4},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {0035-8711},
  doi       = {10.1093/mnras/stx2984},
  pages     = {4298 -- 4308},
  year      = {2018},
  abstract  = {High-velocity clouds (HVCs) are interstellar clouds of atomic hydrogen that do not follow normal Galactic rotation and have velocities of a several hundred kilometres per second. A considerable number of these clouds are falling down towards the Galactic disc. HVCs form large and massive complexes, so if they collide with the disc a great amount of energy would be released into the interstellar medium. The cloud-disc interaction produces two shocks: one propagates through the cloud and the other through the disc. The properties of these shocks depend mainly on the cloud velocity and the disc-cloud density ratio. In this work, we study the conditions necessary for these shocks to accelerate particles by diffusive shock acceleration and we study the non-thermal radiation that is produced. We analyse particle acceleration in both the cloud and disc shocks. Solving a time-dependent two-dimensional transport equation for both relativistic electrons and protons, we obtain particle distributions and non-thermal spectral energy distributions. In a shocked cloud, significant synchrotron radio emission is produced along with soft gamma rays. In the case of acceleration in the shocked disc, the non-thermal radiation is stronger; the gamma rays, of leptonic origin, might be detectable with current instruments. A large number of protons are injected into the Galactic interstellar medium, and locally exceed the cosmic ray background. We conclude that under adequate conditions the contribution from HVC-disc collisions to the galactic population of relativistic particles and the associated extended non-thermal radiation might be important.},
  language  = {en}
}
@article{FeinerTeschnerTeschneretal.2019,
  author    = {Feiner, Rebecca Christine and Teschner, Julian and Teschner, Kathrin E. and Radukic, Marco T. and Baumann, Tobias and Hagen, Sven and Hannappel, Yvonne and Biere, Niklas and Anselmetti, Dario and Arndt, Katja Maren and M{\"u}ller, Kristian Mark},
  title     = {rAAV Engineering for Capsid-Protein Enzyme Insertions and Mosaicism Reveals Resilience to Mutational, Structural and Thermal Perturbations},
  series = {International journal of molecular sciences},
  volume    = {20},
  journal   = {International journal of molecular sciences},
  number    = {22},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1422-0067},
  doi       = {10.3390/ijms20225702},
  pages     = {19},
  year      = {2019},
  abstract  = {Recombinant adeno-associated viruses (rAAV) provide outstanding options for customization and superior capabilities for gene therapy. To access their full potential, facile genetic manipulation is pivotal, including capsid loop modifications. Therefore, we assessed capsid tolerance to modifications of the structural VP proteins in terms of stability and plasticity. Flexible glycine-serine linkers of increasing sizes were, at the genetic level, introduced into the 587 loop region of the VP proteins of serotype 2, the best studied AAV representative. Analyses of biological function and thermal stability with respect to genome release of viral particles revealed structural plasticity. In addition, insertion of the 29 kDa enzyme beta-lactamase into the loop region was tested with a complete or a mosaic modification setting. For the mosaic approach, investigation of VP2 trans expression revealed that a Kozak sequence was required to prevent leaky scanning. Surprisingly, even the full capsid modification with beta-lactamase allowed for the assembly of capsids with a concomitant increase in size. Enzyme activity assays revealed lactamase functionality for both rAAV variants, which demonstrates the structural robustness of this platform technology.},
  language  = {en}
}
@article{GomezMerinoBrearleyOrnatowskaetal.2004,
  author    = {Gomez-Merino, Fernando Carlos and Brearley, C. A. and Ornatowska, Magdalena and Abdel-Haliem, Mahmoud E. F. and Zanor, Maria Ines and M{\"u}ller-R{\"o}ber, Bernd},
  title     = {AtDGK2, a novel diacylglycerol kinase from Arabidopsis thaliana, phosphorylates 1-stearoyl-2-arachidonoyl-sn- glycerol and 1,2-dioleoyl-sn-glycerol and exhibits cold-inducible gene expression},
  issn      = {0021-9258},
  year      = {2004},
  abstract  = {Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Both DAG and PA are implicated in signal transduction pathways. DGKs have been widely studied in animals, but their analysis in plants is fragmentary. Here, we report the cloning and biochemical characterization of AtDGK2, encoding DGK from Arabidopsis thaliana. AtDGK2 has a predicted molecular mass of 79.4 kDa and, like AtDGK1 previously reported, harbors two copies of a phorbol ester/DAG-binding domain in its N-terminal region. AtDGK2 belongs to a family of seven DGK genes in A. thaliana. AtDGK3 to AtDGK7 encode similar to55-kDa DGKs that lack a typical phorbol ester/DAG-binding domain. Phylogenetically, plant DGKs fall into three clusters. Members of all three clusters are widely expressed in vascular plants. Recombinant AtDGK2 was expressed in Escherichia coli and biochemically characterized. The enzyme phosphorylated 1,2-dioleoyl-sn-glycerol to yield PA, exhibiting Michaelis-Menten type kinetics. Estimated K-m and V-max values were 125 muM for DAG and 0.25 pmol of PA min(-1) mug(-1), respectively. The enzyme was maximally active at pH 7.2. Its activity was Mg2+-dependent and affected by the presence of detergents, salts, and the DGK inhibitor R59022, but not by Ca2+. AtDGK2 exhibited substrate preference for unsaturated DAG analogues (i.e. 1-stearoyl-2-arachidonoyl-sn-glycerol and 1,2- dioleoyl-sn-glycerol). The AtDGK2 gene is expressed in various tissues of the Arabidopsis plant, including leaves, roots, and flowers, as shown by Northern blot analysis and promoter-reporter gene fusions. We found that AtDGK2 is induced by exposure to low temperature (4degreesC), pointing to a role in cold signal transduction},
  language  = {en}
}
@article{GrottKnollenbergHammetal.2019,
  author    = {Grott, Matthias and Knollenberg, J. and Hamm, M. and Ogawa, K. and Jaumann, R. and Otto, Katharina Alexandra and Delbo, M. and Michel, P. and Biele, J. and Neumann, W. and Knapmeyer, M. and Kuehrt, E. and Senshu, H. and Okada, T. and Helbert, J. and Maturilli, A. and M{\"u}ller, N. and Hagermann, A. and Sakatani, N. and Tanaka, S. and Arai, T. and Mottola, S. and Tachibana, S. and Pelivan, Ivanka and Drube, L. and Vincent, J-B and Yano, H. and Pilorget, C. and Matz, K. D. and Schmitz, N. and Koncz, A. and Schr{\"o}der, S. E. and Trauthan, F. and Schlotterer, M. and Krause, C. and Ho, T-M and Moussi-Soffys, A.},
  title     = {Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu},
  series = {Nature astronomy},
  volume    = {3},
  journal   = {Nature astronomy},
  number    = {11},
  publisher = {Nature Publishing Group},
  address   = {London},
  issn      = {2397-3366},
  doi       = {10.1038/s41550-019-0832-x},
  pages     = {971 -- 976},
  year      = {2019},
  abstract  = {C-type asteroids are among the most pristine objects in the Solar System, but little is known about their interior structure and surface properties. Telescopic thermal infrared observations have so far been interpreted in terms of a regolith-covered surface with low thermal conductivity and particle sizes in the centimetre range. This includes observations of C-type asteroid (162173) Ryugu1,2,3. However, on arrival of the Hayabusa2 spacecraft at Ryugu, a regolith cover of sand- to pebble-sized particles was found to be absent4,5 (R.J. et al., manuscript in preparation). Rather, the surface is largely covered by cobbles and boulders, seemingly incompatible with the remote-sensing infrared observations. Here we report on in situ thermal infrared observations of a boulder on the C-type asteroid Ryugu. We found that the boulder's thermal inertia was much lower than anticipated based on laboratory measurements of meteorites, and that a surface covered by such low-conductivity boulders would be consistent with remote-sensing observations. Our results furthermore indicate high boulder porosities as well as a low tensile strength in the few hundred kilopascal range. The predicted low tensile strength confirms the suspected observational bias6 in our meteorite collections, as such asteroidal material would be too frail to survive atmospheric entry7.},
  language  = {en}
}
@article{GrottKnollenbergHammetal.2019,
  author    = {Grott, Matthias and Knollenberg, J. and Hamm, M. and Ogawa, K. and Jaumann, R. and Otto, Katharina Alexandra and Delbo, M. and Michel, Patrick and Biele, J. and Neumann, Wladimir and Knapmeyer, Martin and K{\"u}hrt, E. and Senshu, H. and Okada, T. and Helbert, Jorn and Maturilli, A. and M{\"u}ller, N. and Hagermann, A. and Sakatani, Naoya and Tanaka, S. and Arai, T. and Mottola, Stefano and Tachibana, Shogo and Pelivan, Ivanka and Drube, Line and Vincent, J-B and Yano, Hajime and Pilorget, C. and Matz, K. D. and Schmitz, N. and Koncz, A. and Schr{\"o}der, Stefan E. and Trauthan, F. and Schlotterer, Markus and Krause, C. and Ho, T-M and Moussi-Soffys, A.},
  title     = {Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu},
  series = {Nature astronomy},
  volume    = {3},
  journal   = {Nature astronomy},
  number    = {11},
  publisher = {Nature Publishing Group},
  address   = {London},
  issn      = {2397-3366},
  doi       = {10.1038/s41550-019-0832-x},
  pages     = {971 -- 976},
  year      = {2019},
  abstract  = {C-type asteroids are among the most pristine objects in the Solar System, but little is known about their interior structure and surface properties. Telescopic thermal infrared observations have so far been interpreted in terms of a regolith-covered surface with low thermal conductivity and particle sizes in the centimetre range. This includes observations of C-type asteroid (162173) Ryugu1,2,3. However, on arrival of the Hayabusa2 spacecraft at Ryugu, a regolith cover of sand- to pebble-sized particles was found to be absent4,5 (R.J. et al., manuscript in preparation). Rather, the surface is largely covered by cobbles and boulders, seemingly incompatible with the remote-sensing infrared observations. Here we report on in situ thermal infrared observations of a boulder on the C-type asteroid Ryugu. We found that the boulder's thermal inertia was much lower than anticipated based on laboratory measurements of meteorites, and that a surface covered by such low-conductivity boulders would be consistent with remote-sensing observations. Our results furthermore indicate high boulder porosities as well as a low tensile strength in the few hundred kilopascal range. The predicted low tensile strength confirms the suspected observational bias6 in our meteorite collections, as such asteroidal material would be too frail to survive atmospheric entry7},
  language  = {en}
}
@article{JungingerKuebelSchacheretal.2013,
  author    = {Junginger, Mathias and K{\"u}bel, Christian and Schacher, Felix H. and M{\"u}ller, Axel H. E. and Taubert, Andreas},
  title     = {Crystal structure and chemical composition of biomimetric calcium phosphate nanofibers},
  doi       = {10.1039/c3ra23348k},
  year      = {2013},
  abstract  = {Calcium phosphate nanofibers with a diameter of only a few nanometers and a cotton-ball-like aggregate morphology have been reported several times in the literature. Although fiber formation seems reproducible in a variety of conditions, the crystal structure and chemical composition of the fibers have been elusive. Using scanning transmission electron microscopy, low dose electron (nano)diffraction, energy-dispersive X-ray spectroscopy, and energy- filtered transmission electron microscopy, we have assigned crystal structures and chemical compositions to the fibers. Moreover, we demonstrate that the mineralization process yields true polymer/calcium phosphate hybrid materials where the block copolymer template is closely associated with the calcium phosphate.},
  language  = {en}
}
@article{JungingerKuebelSchacheretal.2013,
  author    = {Junginger, Mathias and K{\"u}bel, Christian and Schacher, Felix H. and M{\"u}ller, Axel H. E. and Taubert, Andreas},
  title     = {Crystal structure and chemical composition of biomimetic calcium phosphate nanofibers},
  series = {RSC Advances},
  volume    = {3},
  journal   = {RSC Advances},
  number    = {28},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {2046-2069},
  doi       = {10.1039/c3ra23348k},
  pages     = {11301 -- 11308},
  year      = {2013},
  abstract  = {Calcium phosphate nanofibers with a diameter of only a few nanometers and a cotton-ball-like aggregate morphology have been reported several times in the literature. Although fiber formation seems reproducible in a variety of conditions, the crystal structure and chemical composition of the fibers have been elusive. Using scanning transmission electron microscopy, low dose electron (nano) diffraction, energy-dispersive X-ray spectroscopy, and energy-filtered transmission electron microscopy, we have assigned crystal structures and chemical compositions to the fibers. Moreover, we demonstrate that the mineralization process yields true polymer/calcium phosphate hybrid materials where the block copolymer template is closely associated with the calcium phosphate.},
  language  = {en}
}
@article{KleinDarvinMeinkeetal.2013,
  author    = {Klein, Julia and Darvin, Maxim E. and Meinke, Martina C. and Schweigert, Florian J. and M{\"u}ller, Kerstin E. and Lademann, J{\"u}rgen},
  title     = {Analyses of the correlation between dermal and blood carotenoids in female cattle by optical methods},
  series = {Journal of biomedical optics},
  volume    = {18},
  journal   = {Journal of biomedical optics},
  number    = {6},
  publisher = {SPIE},
  address   = {Bellingham},
  issn      = {1083-3668},
  doi       = {10.1117/1.JBO.18.6.061219},
  pages     = {6},
  year      = {2013},
  abstract  = {Herd health programs for the maintenance of welfare and productivity in cattle need efficient tools for monitoring the health of individual animals. Recent reports demonstrate that the oxidative status is related to various stress conditions in dairy cows. Biomarkers, among other carotenoids, could serve as indicators of stress originating from the environment (e.g., heat stress or sun radiation) or from the animal itself (e.g., disease). To date, only invasive in vitro tests are available to assess the oxidative status in cattle. The present study compares the results of optical noninvasive in vivo measurements of dermal carotenoids in cattle udder skin using an LED-based miniaturized spectroscopic system (MSS) with those obtained by photometric analysis of beta carotene in whole blood samples using a portable device. Correlations between the concentrations of dermal and blood carotenoids were calculated under consideration of the nutritional status of the animals. Significant correlation (R = 0.86) was found for cattle with a moderate to obese body condition. Thus, the blood and skin concentrations of the marker substance beta carotene are comparable under stable stress conditions of the cattle. This demonstrates that the MSS is suitable for noninvasive assessment of dermal carotenoid concentrations in cattle.},
  language  = {en}
}
@article{LotkowskaTohgeFernieetal.2015,
  author    = {Lotkowska, Magda E. and Tohge, Takayuki and Fernie, Alisdair R. and Xue, Gang-Ping and Balazadeh, Salma and M{\"u}ller-R{\"o}ber, Bernd},
  title     = {The Arabidopsis Transcription Factor MYB112 Promotes Anthocyanin Formation during Salinity and under High Light Stress},
  series = {Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants},
  volume    = {169},
  journal   = {Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants},
  number    = {3},
  publisher = {American Society of Plant Physiologists},
  address   = {Rockville},
  issn      = {0032-0889},
  doi       = {10.1104/pp.15.00605},
  pages     = {1862 -- 1880},
  year      = {2015},
  abstract  = {MYB transcription factors (TFs) are important regulators of flavonoid biosynthesis in plants. Here, we report MYB112 as a formerly unknown regulator of anthocyanin accumulation in Arabidopsis (Arabidopsis thaliana). Expression profiling after chemically induced overexpression of MYB112 identified 28 up-and 28 down-regulated genes 5 h after inducer treatment, including MYB7 and MYB32, which are both induced. In addition, upon extended induction, MYB112 also positively affects the expression of PRODUCTION OF ANTHOCYANIN PIGMENT1, a key TF of anthocyanin biosynthesis, but acts negatively toward MYB12 and MYB111, which both control flavonol biosynthesis. MYB112 binds to an 8-bp DNA fragment containing the core sequence (A/T/G)(A/C) CC(A/T)(A/G/T)(A/C)(T/C). By electrophoretic mobility shift assay and chromatin immunoprecipitation coupled to quantitative polymerase chain reaction, we show that MYB112 binds in vitro and in vivo to MYB7 and MYB32 promoters, revealing them as direct downstream target genes. We further show that MYB112 expression is up-regulated by salinity and high light stress, environmental parameters that both require the MYB112 TF for anthocyanin accumulation under these stresses. In contrast to several other MYB TFs affecting anthocyanin biosynthesis, MYB112 expression is not controlled by nitrogen limitation or an excess of carbon. Thus, MYB112 constitutes a regulator that promotes anthocyanin accumulation under abiotic stress conditions.},
  language  = {en}
}
@article{MartielMuellerWerkmeisterCohen2019,
  author    = {Martiel, Isabelle and M{\"u}ller-Werkmeister, Henrike and Cohen, Aina E.},
  title     = {Strategies for sample delivery for femtosecond crystallography},
  series = {Acta Crystallographica : Section D, Structural biology},
  volume    = {75},
  journal   = {Acta Crystallographica : Section D, Structural biology},
  publisher = {Bognor Regis},
  address   = {Wiley},
  issn      = {2059-7983},
  doi       = {10.1107/S2059798318017953},
  pages     = {160 -- 177},
  year      = {2019},
  abstract  = {Highly efficient data-collection methods are required for successful macromolecular crystallography (MX) experiments at X-ray free-electron lasers (XFELs). XFEL beamtime is scarce, and the high peak brightness of each XFEL pulse destroys the exposed crystal volume. It is therefore necessary to combine diffraction images from a large number of crystals (hundreds to hundreds of thousands) to obtain a final data set, bringing about sample-refreshment challenges that have previously been unknown to the MX synchrotron community. In view of this experimental complexity, a number of sample delivery methods have emerged, each with specific requirements, drawbacks and advantages. To provide useful selection criteria for future experiments, this review summarizes the currently available sample delivery methods, emphasising the basic principles and the specific sample requirements. Two main approaches to sample delivery are first covered: (i) injector methods with liquid or viscous media and (ii) fixed-target methods using large crystals or using microcrystals inside multi-crystal holders or chips. Additionally, hybrid methods such as acoustic droplet ejection and crystal extraction are covered, which combine the advantages of both fixed-target and injector approaches.},
  language  = {en}
}
@article{MerdithWilliamsBruneetal.2018,
  author    = {Merdith, Andrew S. and Williams, Simon E. and Brune, Sascha and Collins, Alan S. and M{\"u}ller, R. Dietmar},
  title     = {Rift and plate boundary evolution across two supercontinent cycles},
  series = {Global and planetary change},
  volume    = {173},
  journal   = {Global and planetary change},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0921-8181},
  doi       = {10.1016/j.gloplacha.2018.11.006},
  pages     = {1 -- 14},
  year      = {2018},
  abstract  = {The extent of continental rifts and subduction zones through deep geological time provides insights into the mechanisms behind supercontinent cycles and the long term evolution of the mantle. However, previous compilations have stopped short of mapping the locations of rifts and subduction zones continuously since the Neoproterozoic and within a self-consistent plate kinematic framework. Using recently published plate models with continuously closing boundaries for the Neoproterozoic and Phanerozoic, we estimate how rift and peri-continental subduction length vary from 1 Ga to present and test hypotheses pertaining to the supercontinent cycle and supercontinent breakup. We extract measures of continental perimeter-to-area ratio as a proxy for the existence of a supercontinent, where during times of supercontinent existence the perimeter-to-area ratio should be low, and during assembly and dispersal it should be high. The amalgamation of Gondwana is clearly represented by changes in the length of peri-continental subduction and the breakup of Rodinia and Pangea by changes in rift lengths. The assembly of Pangea is not clearly defined using plate boundary lengths, likely because its formation resulted from the collision of only two large continents. Instead the assembly of Gondwana (ca. 520 Ma) marks the most prominent change in arc length and perimeter-to-area ratio during the last billion years suggesting that Gondwana during the Early Palaeozoic could explicitly be considered part of a Phanerozoic supercontinent. Consequently, the traditional understanding of the supercontinent cycle, in terms of supercontinent existence for short periods of time before dispersal and re-accretion, may be inadequate to fully describe the cycle. Instead, either a two-stage supercontinent cycle could be a more appropriate concept, or alternatively the time period of 1 to 0 Ga has to be considered as being dominated by supercontinent existence, with brief periods of dispersal and amalgamation.},
  language  = {en}
}
@article{MuellerFoerstendorfSteudtneretal.2019,
  author    = {M{\"u}ller, Katharina and Foerstendorf, Harald and Steudtner, Robin and Tsushima, Satoru and Kumke, Michael Uwe and Lef{\`e}vre, Gr{\´e}gory and Rothe, J{\"o}rg and Mason, Harris and Szab{\´o}, Zolt{\´a}n and Yang, Ping and Adam, Christian K. R. and Andr{\´e}, R{\´e}mi and Brennenstuhl, Katlen and Chiorescu, Ion and Cho, Herman M. and Creff, Ga{\"e}lle and Coppin, Fr{\´e}d{\´e}ric and Dardenne, Kathy and Den Auwer, Christophe and Drobot, Bj{\"o}rn and Eidner, Sascha and Hess, Nancy J. and Kaden, Peter and Kremleva, Alena and Kretzschmar, Jerome and Kr{\"u}ger, Sven and Platts, James A. and Panak, Petra and Polly, Robert and Powell, Brian A. and Rabung, Thomas and Redon, Roland and Reiller, Pascal E. and R{\"o}sch, Notker and Rossberg, Andr{\´e} and Scheinost, Andreas C. and Schimmelpfennig, Bernd and Schreckenbach, Georg and Skerencak-Frech, Andrej and Sladkov, Vladimir and Solari, Pier Lorenzo and Wang, Zheming and Washton, Nancy M. and Zhang, Xiaobin},
  title     = {Interdisciplinary Round-Robin Test on molecular spectroscopy of the U(VI) Acetate System},
  series = {ACS omega / American Chemical Society},
  volume    = {4},
  journal   = {ACS omega / American Chemical Society},
  number    = {5},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {2470-1343},
  doi       = {10.1021/acsomega.9b00164},
  pages     = {8167 -- 8177},
  year      = {2019},
  abstract  = {A comprehensive molecular analysis of a simple aqueous complexing system. U(VI) acetate. selected to be independently investigated by various spectroscopic (vibrational, luminescence, X-ray absorption, and nuclear magnetic resonance spectroscopy) and quantum chemical methods was achieved by an international round-robin test (RRT). Twenty laboratories from six different countries with a focus on actinide or geochemical research participated and contributed to this scientific endeavor. The outcomes of this RRT were considered on two levels of complexity: first, within each technical discipline, conformities as well as discrepancies of the results and their sources were evaluated. The raw data from the different experimental approaches were found to be generally consistent. In particular, for complex setups such as accelerator-based X-ray absorption spectroscopy, the agreement between the raw data was high. By contrast, luminescence spectroscopic data turned out to be strongly related to the chosen acquisition parameters. Second, the potentials and limitations of coupling various spectroscopic and theoretical approaches for the comprehensive study of actinide molecular complexes were assessed. Previous spectroscopic data from the literature were revised and the benchmark data on the U(VI) acetate system provided an unambiguous molecular interpretation based on the correlation of spectroscopic and theoretical results. The multimethodologic approach and the conclusions drawn address not only important aspects of actinide spectroscopy but particularly general aspects of modern molecular analytical chemistry.},
  language  = {en}
}
@article{MuellerAltenkampRailaetal.2011,
  author    = {M{\"u}ller, Kerstin E. and Altenkamp, Rainer and Raila, Jens and Schmidt, Daniel and Dietrich, Robert and Hurtienne, Andrea and Wink, Michael and Krone, Oliver and Brunnberg, Leo and Schweigert, Florian J.},
  title     = {Plasma concentration of alpha-tocopherol in different free-ranging birds of prey},
  series = {European journal of wildlife research},
  volume    = {57},
  journal   = {European journal of wildlife research},
  number    = {5},
  publisher = {Springer},
  address   = {New York},
  issn      = {1612-4642},
  doi       = {10.1007/s10344-011-0516-z},
  pages     = {1043 -- 1049},
  year      = {2011},
  abstract  = {In this study, we investigated the alpha-tocopherol plasma concentrations in healthy free-ranging nestlings of the white-tailed sea eagle (Haliaeetus albicilla) (n=32), osprey (Pandion haliaetus) (n=39), northern goshawk (Accipiter gentilis) (n=25), common buzzard (Buteo buteo) (n=31), and honey buzzard (Pernis apivorus) (n=18) as well as of free-ranging adults of the white-tailed sea eagle (n=10), osprey (n=31), and northern goshawk (n=45). alpha-Tocopherol plasma concentrations were determined by reverse-phase high-performance liquid chromatography. alpha-Tocopherol plasma concentrations in nestlings of osprey, white-tailed sea eagle, and northern goshawk did not differ significantly amongst the species, but the common buzzard and honey buzzard nestlings had significantly lower alpha-tocopherol plasma concentrations than nestlings of the other species (both P<0.001). Adult male ospreys and white-tailed sea eagles had significantly higher alpha-tocopherol concentrations compared to adult females (both P<0.005). Adult ospreys and northern goshawks had significantly higher alpha-tocopherol plasma concentrations compared to their nestlings (both P<0.001). In adult female northern goshawks, plasma concentrations of alpha-tocopherol increased significantly before egg laying (P<0.001). These results demonstrate alpha-tocopherol plasma concentrations in birds of prey to be species specific and influenced by age and reproductive status.},
  language  = {en}
}
@article{NellesenLaquaiMuelleretal.2018,
  author    = {Nellesen, Jens and Laquai, R. and M{\"u}ller, B. R. and Kupsch, Andreas and Hentschel, M. P. and Anar, N. B. and Soppa, E. and Tillmann, W. and Bruno, Giovanni},
  title     = {In situ analysis of damage evolution in an Al/ Al2O3 MMC under tensile load by synchrotron X-ray refraction imaging},
  series = {Journal of materials science},
  volume    = {53},
  journal   = {Journal of materials science},
  number    = {8},
  publisher = {Springer},
  address   = {New York},
  issn      = {0022-2461},
  doi       = {10.1007/s10853-017-1957-x},
  pages     = {6021 -- 6032},
  year      = {2018},
  abstract  = {The in situ analysis of the damage evolution in a metal matrix composite (MMC) using synchrotron X-ray refraction radiography (SXRR) is presented. The investigated material is an Al alloy (6061)/10 vol MMC after T6 heat treatment. In an interrupted tensile test the gauge section of dog bone-shaped specimens is imaged in different states of tensile loading. On the basis of the SXRR images, the relative change of the specific surface (proportional to the amount of damage) in the course of tensile loading was analyzed. It could be shown that the damage can be detected by SXRR already at a stage of tensile loading, in which no observation of damage is possible with radiographic absorption-based imaging methods. Moreover, the quantitative analysis of the SXRR images reveals that the amount of damage increases homogeneously by an average of 25\% with respect to the initial state. To corroborate the experimental findings, the damage distribution was imaged in 3D after the final tensile loading by synchrotron X-ray refraction computed tomography (SXRCT) and absorption-based synchrotron X-ray computed tomography (SXCT). It could be evidenced that defects and damages cause pronounced indications in the SXRCT images.},
  language  = {en}
}
@article{RaatzBacchiPirhoferWalzletal.2019,
  author    = {Raatz, Larissa and Bacchi, Nina and Pirhofer Walzl, Karin and Glemnitz, Michael and M{\"u}ller, Marina E. H. and Jasmin Radha, Jasmin and Scherber, Christoph},
  title     = {How much do we really lose?},
  series = {Ecology and Evolution},
  volume    = {9},
  journal   = {Ecology and Evolution},
  number    = {13},
  publisher = {John Wiley \& Sons},
  address   = {S.I.},
  issn      = {2045-7758},
  doi       = {10.1002/ece3.5370},
  pages     = {7838 -- 7848},
  year      = {2019},
  abstract  = {Natural landscape elements (NLEs) in agricultural landscapes contribute to biodiversity and ecosystem services, but are also regarded as an obstacle for large-scale agricultural production. However, the effects of NLEs on crop yield have rarely been measured. Here, we investigated how different bordering structures, such as agricultural roads, field-to-field borders, forests, hedgerows, and kettle holes, influence agricultural yields. We hypothesized that (a) yield values at field borders differ from mid-field yields and that (b) the extent of this change in yields depends on the bordering structure. We measured winter wheat yields along transects with log-scaled distances from the border into the agricultural field within two intensively managed agricultural landscapes in Germany (2014 near G{\"o}ttingen, and 2015-2017 in the Uckermark). We observed a yield loss adjacent to every investigated bordering structure of 11\%-38\% in comparison with mid-field yields. However, depending on the bordering structure, this yield loss disappeared at different distances. While the proximity of kettle holes did not affect yields more than neighboring agricultural fields, woody landscape elements had strong effects on winter wheat yields. Notably, 95\% of mid-field yields could already be reached at a distance of 11.3 m from a kettle hole and at a distance of 17.8 m from hedgerows as well as forest borders. Our findings suggest that yield losses are especially relevant directly adjacent to woody landscape elements, but not adjacent to in-field water bodies. This highlights the potential to simultaneously counteract yield losses close to the field border and enhance biodiversity by combining different NLEs in agricultural landscapes such as creating strips of extensive grassland vegetation between woody landscape elements and agricultural fields. In conclusion, our results can be used to quantify ecocompensations to find optimal solutions for the delivery of productive and regulative ecosystem services in heterogeneous agricultural landscapes.},
  language  = {en}
}
@article{RaatzBacchiWalzletal.2019,
  author    = {Raatz, Larissa and Bacchi, Nina and Walzl, Karin Pirhofer and Glemnitz, Michael and M{\"u}ller, Marina E. H. and Jasmin Radha, Jasmin and Scherber, Christoph},
  title     = {How much do we really lose?},
  series = {Ecology and evolution},
  volume    = {9},
  journal   = {Ecology and evolution},
  number    = {13},
  publisher = {Wiley},
  address   = {Hoboken},
  issn      = {2045-7758},
  doi       = {10.1002/ece3.5370},
  pages     = {7838 -- 7848},
  year      = {2019},
  abstract  = {Natural landscape elements (NLEs) in agricultural landscapes contribute to biodiversity and ecosystem services, but are also regarded as an obstacle for large-scale agricultural production. However, the effects of NLEs on crop yield have rarely been measured. Here, we investigated how different bordering structures, such as agricultural roads, field-to-field borders, forests, hedgerows, and kettle holes, influence agricultural yields. We hypothesized that (a) yield values at field borders differ from mid-field yields and that (b) the extent of this change in yields depends on the bordering structure. We measured winter wheat yields along transects with log-scaled distances from the border into the agricultural field within two intensively managed agricultural landscapes in Germany (2014 near Gottingen, and 2015-2017 in the Uckermark). We observed a yield loss adjacent to every investigated bordering structure of 11\%-38\% in comparison with mid-field yields. However, depending on the bordering structure, this yield loss disappeared at different distances. While the proximity of kettle holes did not affect yields more than neighboring agricultural fields, woody landscape elements had strong effects on winter wheat yields. Notably, 95\% of mid-field yields could already be reached at a distance of 11.3 m from a kettle hole and at a distance of 17.8 m from hedgerows as well as forest borders. Our findings suggest that yield losses are especially relevant directly adjacent to woody landscape elements, but not adjacent to in-field water bodies. This highlights the potential to simultaneously counteract yield losses close to the field border and enhance biodiversity by combining different NLEs in agricultural landscapes such as creating strips of extensive grassland vegetation between woody landscape elements and agricultural fields. In conclusion, our results can be used to quantify ecocompensations to find optimal solutions for the delivery of productive and regulative ecosystem services in heterogeneous agricultural landscapes.},
  language  = {en}
}
@article{RaatzPirhoferWalzlMuelleretal.2021,
  author    = {Raatz, Larissa and Pirhofer-Walzl, Karin and M{\"u}ller, Marina E.H. and Scherber, Christoph and Joshi, Jasmin Radha},
  title     = {Who is the culprit: Is pest infestation responsible for crop yield losses close to semi-natural habitats?},
  series = {Ecology and Evolution},
  volume    = {11},
  journal   = {Ecology and Evolution},
  edition   = {19},
  publisher = {Wiley-Blackwell},
  address   = {Oxford},
  issn      = {1467-6435},
  doi       = {10.1002/ece3.8046},
  pages     = {13232 -- 13246},
  year      = {2021},
  abstract  = {Semi-natural habitats (SNHs) are becoming increasingly scarce in modern agricultural landscapes. This may reduce natural ecosystem services such as pest control with its putatively positive effect on crop production. In agreement with other studies, we recently reported wheat yield reductions at field borders which were linked to the type of SNH and the distance to the border. In this experimental landscape-wide study, we asked whether these yield losses have a biotic origin while analyzing fungal seed and fungal leaf pathogens, herbivory of cereal leaf beetles, and weed cover as hypothesized mediators between SNHs and yield. We established experimental winter wheat plots of a single variety within conventionally managed wheat fields at fixed distances either to a hedgerow or to an in-field kettle hole. For each plot, we recorded the fungal infection rate on seeds, fungal infection and herbivory rates on leaves, and weed cover. Using several generalized linear mixed-effects models as well as a structural equation model, we tested the effects of SNHs at a field scale (SNH type and distance to SNH) and at a landscape scale (percentage and diversity of SNHs within a 1000-m radius). In the dry year of 2016, we detected one putative biotic culprit: Weed cover was negatively associated with yield values at a 1-m and 5-m distance from the field border with a SNH. None of the fungal and insect pests, however, significantly affected yield, neither solely nor depending on type of or distance to a SNH. However, the pest groups themselves responded differently to SNH at the field scale and at the landscape scale. Our findings highlight that crop losses at field borders may be caused by biotic culprits; however, their negative impact seems weak and is putatively reduced by conventional farming practices.},
  language  = {en}
}
@article{RaatzPirhoferWalzlMuelleretal.2021,
  author    = {Raatz, Larissa and Pirhofer-Walzl, Karin and M{\"u}ller, Marina E.H. and Scherber, Christoph and Joshi, Jasmin Radha},
  title     = {Who is the culprit: Is pest infestation responsible for crop yield losses close to semi-natural habitats?},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-54962},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-549622},
  pages     = {13232 -- 13246},
  year      = {2021},
  abstract  = {Semi-natural habitats (SNHs) are becoming increasingly scarce in modern agricultural landscapes. This may reduce natural ecosystem services such as pest control with its putatively positive effect on crop production. In agreement with other studies, we recently reported wheat yield reductions at field borders which were linked to the type of SNH and the distance to the border. In this experimental landscape-wide study, we asked whether these yield losses have a biotic origin while analyzing fungal seed and fungal leaf pathogens, herbivory of cereal leaf beetles, and weed cover as hypothesized mediators between SNHs and yield. We established experimental winter wheat plots of a single variety within conventionally managed wheat fields at fixed distances either to a hedgerow or to an in-field kettle hole. For each plot, we recorded the fungal infection rate on seeds, fungal infection and herbivory rates on leaves, and weed cover. Using several generalized linear mixed-effects models as well as a structural equation model, we tested the effects of SNHs at a field scale (SNH type and distance to SNH) and at a landscape scale (percentage and diversity of SNHs within a 1000-m radius). In the dry year of 2016, we detected one putative biotic culprit: Weed cover was negatively associated with yield values at a 1-m and 5-m distance from the field border with a SNH. None of the fungal and insect pests, however, significantly affected yield, neither solely nor depending on type of or distance to a SNH. However, the pest groups themselves responded differently to SNH at the field scale and at the landscape scale. Our findings highlight that crop losses at field borders may be caused by biotic culprits; however, their negative impact seems weak and is putatively reduced by conventional farming practices.},
  language  = {en}
}
@article{ReadKegelKluteetal.2013,
  author    = {Read, Betsy A. and Kegel, Jessica and Klute, Mary J. and Kuo, Alan and Lefebvre, Stephane C. and Maumus, Florian and Mayer, Christoph and Miller, John and Monier, Adam and Salamov, Asaf and Young, Jeremy and Aguilar, Maria and Claverie, Jean-Michel and Frickenhaus, Stephan and Gonzalez, Karina and Herman, Emily K. and Lin, Yao-Cheng and Napier, Johnathan and Ogata, Hiroyuki and Sarno, Analissa F. and Shmutz, Jeremy and Schroeder, Declan and de Vargas, Colomban and Verret, Frederic and von Dassow, Peter and Valentin, Klaus and Van de Peer, Yves and Wheeler, Glen and Dacks, Joel B. and Delwiche, Charles F. and Dyhrman, Sonya T. and Gl{\"o}ckner, Gernot and John, Uwe and Richards, Thomas and Worden, Alexandra Z. and Zhang, Xiaoyu and Grigoriev, Igor V. and Allen, Andrew E. and Bidle, Kay and Borodovsky, M. and Bowler, C. and Brownlee, Colin and Cock, J. Mark and Elias, Marek and Gladyshev, Vadim N. and Groth, Marco and Guda, Chittibabu and Hadaegh, Ahmad and Iglesias-Rodriguez, Maria Debora and Jenkins, J. and Jones, Bethan M. and Lawson, Tracy and Leese, Florian and Lindquist, Erika and Lobanov, Alexei and Lomsadze, Alexandre and Malik, Shehre-Banoo and Marsh, Mary E. and Mackinder, Luke and Mock, Thomas and M{\"u}ller-R{\"o}ber, Bernd and Pagarete, Antonio and Parker, Micaela and Probert, Ian and Quesneville, Hadi and Raines, Christine and Rensing, Stefan A. and Riano-Pachon, Diego Mauricio and Richier, Sophie and Rokitta, Sebastian and Shiraiwa, Yoshihiro and Soanes, Darren M. and van der Giezen, Mark and Wahlund, Thomas M. and Williams, Bryony and Wilson, Willie and Wolfe, Gordon and Wurch, Louie L.},
  title     = {Pan genome of the phytoplankton Emiliania underpins its global distribution},
  series = {Nature : the international weekly journal of science},
  volume    = {499},
  journal   = {Nature : the international weekly journal of science},
  number    = {7457},
  publisher = {Nature Publ. Group},
  address   = {London},
  organization    = {Emiliania Huxleyi Annotation},
  issn      = {0028-0836},
  doi       = {10.1038/nature12221},
  pages     = {209 -- 213},
  year      = {2013},
  abstract  = {Coccolithophores have influenced the global climate for over 200 million years(1). These marine phytoplankton can account for 20 per cent of total carbon fixation in some systems(2). They form blooms that can occupy hundreds of thousands of square kilometres and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), rendering them visible from space(3). Although coccolithophores export carbon in the form of organic matter and calcite to the sea floor, they also release CO2 in the calcification process. Hence, they have a complex influence on the carbon cycle, driving either CO2 production or uptake, sequestration and export to the deep ocean(4). Here we report the first haptophyte reference genome, from the coccolithophore Emiliania huxleyi strain CCMP1516, and sequences from 13 additional isolates. Our analyses reveal a pan genome (core genes plus genes distributed variably between strains) probably supported by an atypical complement of repetitive sequence in the genome. Comparisons across strains demonstrate that E. huxleyi, which has long been considered a single species, harbours extensive genome variability reflected in different metabolic repertoires. Genome variability within this species complex seems to underpin its capacity both to thrive in habitats ranging from the equator to the subarctic and to form large-scale episodic blooms under a wide variety of environmental conditions.},
  language  = {en}
}
@article{RubeyBruneHeineetal.2017,
  author    = {Rubey, Michael and Brune, Sascha and Heine, Christian and Davies, D. Rhodri and Williams, Simon E. and M{\"u}ller, R. Dietmar},
  title     = {role of subducted slabs},
  series = {Solid earth},
  volume    = {8},
  journal   = {Solid earth},
  publisher = {Copernicus},
  address   = {G{\"o}ttingen},
  issn      = {1869-9510},
  doi       = {10.5194/se-8-899-2017},
  pages     = {899 -- 919},
  year      = {2017},
  language  = {en}
}
@article{ScarpeciZanorMuellerRoeberetal.2013,
  author    = {Scarpeci, Telma E. and Zanor, Maria I. and M{\"u}ller-R{\"o}ber, Bernd and Valle, Estela M.},
  title     = {Overexpression of AtWRKY30 enhances abiotic stress tolerance during early growth stages in Arabidopsis thaliana},
  series = {PLANT MOLECULAR BIOLOGY},
  volume    = {83},
  journal   = {PLANT MOLECULAR BIOLOGY},
  number    = {3},
  publisher = {SPRINGER},
  address   = {DORDRECHT},
  issn      = {0167-4412},
  doi       = {10.1007/s11103-013-0090-8},
  pages     = {265 -- 277},
  year      = {2013},
  abstract  = {AtWRKY30 belongs to a higher plant transcription factor superfamily, which responds to pathogen attack. In previous studies, the AtWRKY30 gene was found to be highly and rapidly induced in Arabidopsis thaliana leaves after oxidative stress treatment. In this study, electrophoretic mobility shift assays showed that AtWRKY30 binds with high specificity and affinity to the WRKY consensus sequence (W-box), and also to its own promoter. Analysis of the AtWRKY30 expression pattern by qPCR and using transgenic Arabidopsis lines carrying AtWRKY30 promoter-beta-glucuronidase fusions showed transcriptional activity in leaves subjected to biotic or abiotic stress. Transgenic Arabidopsis plants constitutively overexpressing AtWRKY30 (35S::W30 lines) were more tolerant than wild-type plants to oxidative and salinity stresses during seed germination. The results presented here show that AtWRKY30 is responsive to several stress conditions either from abiotic or biotic origin, suggesting that AtWRKY30 could have a role in the activation of defence responses at early stages of Arabidopsis growth by binding to W-boxes found in promoters of many stress/developmentally regulated genes.},
  language  = {en}
}
@article{SchiroColangeliMueller2019,
  author    = {Schiro, Gabriele and Colangeli, Pierluigi and M{\"u}ller, Marina E. H.},
  title     = {A Metabarcoding Analysis of the Mycobiome of Wheat Ears Across a Topographically Heterogeneous Field},
  series = {Frontiers in microbiology},
  volume    = {10},
  journal   = {Frontiers in microbiology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-302X},
  doi       = {10.3389/fmicb.2019.02095},
  pages     = {12},
  year      = {2019},
  language  = {en}
}
@article{SeemuellerMuellerRoesler2012,
  author    = {Seem{\"u}ller, Anna and M{\"u}ller, E. M. and R{\"o}sler, Frank},
  title     = {EEG-power and -coherence changes in a unimodal and a crossmodal working memory task with visual and kinesthetic stimuli},
  series = {International journal of psychophysiology},
  volume    = {83},
  journal   = {International journal of psychophysiology},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0167-8760},
  doi       = {10.1016/j.ijpsycho.2011.10.009},
  pages     = {87 -- 95},
  year      = {2012},
  abstract  = {We investigated EEG-power and EEG-coherence changes in a unimodal and a crossmodal matching-to-sample working memory task with either visual or kinesthetic stimuli. Angle-shaped trajectories were used as stimuli presented either as a moving dot on a screen or as a passive movement of a haptic device. Effects were evaluated during the different phases of encoding, maintenance, and recognition. Alpha power was modulated during encoding by the stimulus modality, and in crossmodal conditions during encoding and maintenance by the expected modality of the upcoming test stimulus. These power modulations were observed over modality-specific cortex regions. Systematic changes of coherence for crossmodal compared to unimodal tasks were not observed during encoding and maintenance but only during recognition. There, coherence in the theta-band increased between electrode sites over left central and occipital cortex areas in the crossmodal compared to the unimodal conditions. The results underline the importance of modality-specific representations and processes in unimodal and crossmodal working memory tasks. Crossmodal recognition of visually and kinesthetically presented object features seems to be related to a direct interaction of somatosensory/motor and visual cortex regions by means of long-range synchronization in the theta-band and such interactions seem to take place at the beginning of the recognition phase, i.e. when crossmodal transfer is actually necessary.},
  language  = {en}
}
@article{SoliveresvanderPlasManningetal.2016,
  author    = {Soliveres, Santiago and van der Plas, Fons and Manning, Peter and Prati, Daniel and Gossner, Martin M. and Renner, Swen C. and Alt, Fabian and Arndt, Hartmut and Baumgartner, Vanessa and Binkenstein, Julia and Birkhofer, Klaus and Blaser, Stefan and Bl{\"u}thgen, Nico and Boch, Steffen and B{\"o}hm, Stefan and B{\"o}rschig, Carmen and Buscot, Francois and Diek{\"o}tter, Tim and Heinze, Johannes and H{\"o}lzel, Norbert and Jung, Kirsten and Klaus, Valentin H. and Kleinebecker, Till and Klemmer, Sandra and Krauss, Jochen and Lange, Markus and Morris, E. Kathryn and M{\"u}ller, J{\"o}rg and Oelmann, Yvonne and Overmann, J{\"o}rg and Pasalic, Esther and Rillig, Matthias C. and Schaefer, H. Martin and Schloter, Michael and Schmitt, Barbara and Sch{\"o}ning, Ingo and Schrumpf, Marion and Sikorski, Johannes and Socher, Stephanie A. and Solly, Emily F. and Sonnemann, Ilja and Sorkau, Elisabeth and Steckel, Juliane and Steffan-Dewenter, Ingolf and Stempfhuber, Barbara and Tschapka, Marco and T{\"u}rke, Manfred and Venter, Paul C. and Weiner, Christiane N. and Weisser, Wolfgang W. and Werner, Michael and Westphal, Catrin and Wilcke, Wolfgang and Wolters, Volkmar and Wubet, Tesfaye and Wurst, Susanne and Fischer, Markus and Allan, Eric},
  title     = {Biodiversity at multiple trophic levels is needed for ecosystem multifunctionality},
  series = {Nature : the international weekly journal of science},
  volume    = {536},
  journal   = {Nature : the international weekly journal of science},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {0028-0836},
  doi       = {10.1038/nature19092},
  pages     = {456 -- +},
  year      = {2016},
  language  = {en}
}
@article{SollySchoeningBochetal.2014,
  author    = {Solly, Emily F. and Sch{\"o}ning, Ingo and Boch, Steffen and Kandeler, Ellen and Marhan, Sven and Michalzik, Beate and M{\"u}ller, J{\"o}rg and Zscheischler, Jakob and Trumbore, Susan E. and Schrumpf, Marion},
  title     = {Factors controlling decomposition rates of fine root litter in temperate forests and grasslands},
  series = {Plant and soil},
  volume    = {382},
  journal   = {Plant and soil},
  number    = {1-2},
  publisher = {Springer},
  address   = {Dordrecht},
  issn      = {0032-079X},
  doi       = {10.1007/s11104-014-2151-4},
  pages     = {203 -- 218},
  year      = {2014},
  abstract  = {Fine root decomposition contributes significantly to element cycling in terrestrial ecosystems. However, studies on root decomposition rates and on the factors that potentially influence them are fewer than those on leaf litter decomposition. To study the effects of region and land use intensity on fine root decomposition, we established a large scale study in three German regions with different climate regimes and soil properties. Methods In 150 forest and 150 grassland sites we deployed litterbags (100 mu m mesh size) with standardized litter consisting of fine roots from European beech in forests and from a lowland mesophilous hay meadow in grasslands. In the central study region, we compared decomposition rates of this standardized litter with root litter collected on-site to separate the effect of litter quality from environmental factors. Standardized herbaceous roots in grassland soils decomposed on average significantly faster (24 +/- 6 \% mass loss after 12 months, mean +/- SD) than beech roots in forest soils (12 +/- 4 \%; p < 0.001). Fine root decomposition varied among the three study regions. Land use intensity, in particular N addition, decreased fine root decomposition in grasslands. The initial lignin:N ratio explained 15 \% of the variance in grasslands and 11 \% in forests. Soil moisture, soil temperature, and C:N ratios of soils together explained 34 \% of the variance of the fine root mass loss in grasslands, and 24 \% in forests. Grasslands, which have higher fine root biomass and root turnover compared to forests, also have higher rates of root decomposition. Our results further show that at the regional scale fine root decomposition is influenced by environmental variables such as soil moisture, soil temperature and soil nutrient content. Additional variation is explained by root litter quality.},
  language  = {en}
}
@article{SramaAhrensAltobellietal.2004,
  author    = {Srama, Ralf and Ahrens, Thomas J. and Altobelli, Nicolas and Auer, S. and Bradley, J. G. and Burton, M. and Dikarev, V. V. and Economou, T. and Fechtig, Hugo and G{\"o}rlich, M. and Grande, M. and Graps, Amara and Gr{\"u}n, Eberhard and Havnes, Ove and Helfert, Stefan and Horanyi, Mihaly and Igenbergs, E. and Jessberger, Elmar K. and Johnson, T. V. and Kempf, Sascha and Krivov, Alexander v. and Kr{\"u}ger, Harald and Mocker-Ahlreep, Anna and Moragas-Klostermeyer, Georg and Lamy, Philippe and Landgraf, Markus and Linkert, Dietmar and Linkert, G. and Lura, F. and McDonnell, J. A. M. and Moehlmann, Dirk and Morfill, Gregory E. and Muller, M. and Roy, M. and Schafer, G. and Schlotzhauer, G. and Schwehm, Gerhard H. and Spahn, Frank and St{\"u}big, M. and Svestka, Jiri and Tschernjawski, V},
  title     = {The Cassini Cosmic Dust Analyzer},
  issn      = {0038-6308},
  year      = {2004},
  abstract  = {The Cassini-Huygens Cosmic Dust Analyzer (CDA) is intended to provide direct observations of dust grains with masses between 10(-19) and 10(-9) kg in interplanetary space and in the jovian and saturnian systems, to investigate their physical, chemical and dynamical properties as functions of the distances to the Sun, to Jupiter and to Saturn and its satellites and rings, to study their interaction with the saturnian rings, satellites and magnetosphere. Chemical composition of interplanetary meteoroids will be compared with asteroidal and cometary dust, as well as with Saturn dust, ejecta from rings and satellites. Ring and satellites phenomena which might be effects of meteoroid impacts will be compared with the interplanetary dust environment. Electrical charges of particulate matter in the magnetosphere and its consequences will be studied, e.g. the effects of the ambient plasma and the magnetic held on the trajectories of dust particles as well as fragmentation of particles due to electrostatic disruption. The investigation will be performed with an instrument that measures the mass, composition, electric charge, speed, and flight direction of individual dust particles. It is a highly reliable and versatile instrument with a mass sensitivity 106 times higher than that of the Pioneer 10 and I I dust detectors which measured dust in the saturnian system. The Cosmic Dust Analyzer has significant inheritance from former space instrumentation developed for the VEGA, Giotto, Galileo, and Ulysses missions. It will reliably measure impacts from as low as I impact per month up to 104 impacts per second. The instrument weighs 17 kg and consumes 12 W, the integrated time-of-flight mass spectrometer has a mass resolution of up to 50. The nominal data transmission rate is 524 bits/s and varies between 50 and 4192 bps},
  language  = {en}
}
@article{WalterRueckertVossetal.2009,
  author    = {Walter, Juliane K. and R{\"u}ckert, Christine and Voss, Martin and M{\"u}ller, Sebastian L. and Piontek, Joerg and Gast, Klaus and Blasig, Ingolf E.},
  title     = {The oligomerization of the coiled coil-domain of occluddin is redox sensitive},
  issn      = {0077-8923},
  doi       = {10.1111/j.1749-6632.2009.04058.x},
  year      = {2009},
  abstract  = {The transmembrane tight junction protein occludin is sensitive to oxidative stress. Occludin oligomerizes; however, its function in the tight junction is unknown. The cytosolic C-terminal tail contains a coiled coil-domain and forms dimers contributing to the oligomerization. The regulation of the oligomerization remains unclear. As the domain area contains sulfhydryl residues, we tested the hypothesis that the dimerization of the coiled coil-domain depends on these residues. We showed that the dimerization is modulated by the thiol concentration in the low-millimolar range, which is relevant both for physiological and pathophysiological conditions. Masking the sulfhydryl residues in the fragment by covalent binding of 4-vinyl pyridine prevented the dimerization but did not affect its helical structure and cylindric shape. The data demonstrate, for the first time, that disulfide bridge formation of murine cystein 408 is involved in the dimerization. This process is redox-sensitive but the secondary structure of the domain is not. It is concluded that the dimerization of occludin may play a regulatory role in the tight junction assembly under physiological and pathological conditions.},
  language  = {en}
}
@article{WarringtonBeaumontHorikoshietal.2019,
  author    = {Warrington, Nicole and Beaumont, Robin and Horikoshi, Momoko and Day, Felix R. and Helgeland, {\O}yvind and Laurin, Charles and Bacelis, Jonas and Peng, Shouneng and Hao, Ke and Feenstra, Bjarke and Wood, Andrew R. and Mahajan, Anubha and Tyrrell, Jessica and Robertson, Neil R. and Rayner, N. William and Qiao, Zhen and Moen, Gunn-Helen and Vaudel, Marc and Marsit, Carmen and Chen, Jia and Nodzenski, Michael and Schnurr, Theresia M. and Zafarmand, Mohammad Hadi and Bradfield, Jonathan P. and Grarup, Niels and Kooijman, Marjolein N. and Li-Gao, Ruifang and Geller, Frank and Ahluwalia, Tarunveer Singh and Paternoster, Lavinia and Rueedi, Rico and Huikari, Ville and Hottenga, Jouke-Jan and Lyytik{\"a}inen, Leo-Pekka and Cavadino, Alana and Metrustry, Sarah and Cousminer, Diana L. and Wu, Ying and Thiering, Elisabeth Paula and Wang, Carol A. and Have, Christian Theil and Vilor-Tejedor, Natalia and Joshi, Peter K. and Painter, Jodie N. and Ntalla, Ioanna and Myhre, Ronny and Pitk{\"a}nen, Niina and van Leeuwen, Elisabeth M. and Joro, Raimo and Lagou, Vasiliki and Richmond, Rebecca C. and Espinosa, Ana and Barton, Sheila J. and Inskip, Hazel M. and Holloway, John W. and Santa-Marina, Loreto and Estivill, Xavier and Ang, Wei and Marsh, Julie A. and Reichetzeder, Christoph and Marullo, Letizia and Hocher, Berthold and Lunetta, Kathryn L. and Murabito, Joanne M. and Relton, Caroline L. and Kogevinas, Manolis and Chatzi, Leda and Allard, Catherine and Bouchard, Luigi and Hivert, Marie-France and Zhang, Ge and Muglia, Louis J. and Heikkinen, Jani and Morgen, Camilla S. and van Kampen, Antoine H. C. and van Schaik, Barbera D. C. and Mentch, Frank D. and Langenberg, Claudia and Scott, Robert A. and Zhao, Jing Hua and Hemani, Gibran and Ring, Susan M. and Bennett, Amanda J. and Gaulton, Kyle J. and Fernandez-Tajes, Juan and van Zuydam, Natalie R. and Medina-Gomez, Carolina and de Haan, Hugoline G. and Rosendaal, Frits R. and Kutalik, Zolt{\´a}n and Marques-Vidal, Pedro and Das, Shikta and Willemsen, Gonneke and Mbarek, Hamdi and M{\"u}ller-Nurasyid, Martina and Standl, Marie and Appel, Emil V. R. and Fonvig, Cilius Esmann and Trier, Caecilie and van Beijsterveldt, Catharina E. M. and Murcia, Mario and Bustamante, Mariona and Bon{\`a}s-Guarch, S{\´i}lvia and Hougaard, David M. and Mercader, Josep M. and Linneberg, Allan and Schraut, Katharina E. and Lind, Penelope A. and Medland, Sarah Elizabeth and Shields, Beverley M. and Knight, Bridget A. and Chai, Jin-Fang and Panoutsopoulou, Kalliope and Bartels, Meike and S{\´a}nchez, Friman and Stokholm, Jakob and Torrents, David and Vinding, Rebecca K. and Willems, Sara M. and Atalay, Mustafa and Chawes, Bo L. and Kovacs, Peter and Prokopenko, Inga and Tuke, Marcus A. and Yaghootkar, Hanieh and Ruth, Katherine S. and Jones, Samuel E. and Loh, Po-Ru and Murray, Anna and Weedon, Michael N. and T{\"o}njes, Anke and Stumvoll, Michael and Michaelsen, Kim Fleischer and Eloranta, Aino-Maija and Lakka, Timo A. and van Duijn, Cornelia M. and Kiess, Wieland and Koerner, Antje and Niinikoski, Harri and Pahkala, Katja and Raitakari, Olli T. and Jacobsson, Bo and Zeggini, Eleftheria and Dedoussis, George V. and Teo, Yik-Ying and Saw, Seang-Mei and Montgomery, Grant W. and Campbell, Harry and Wilson, James F. and Vrijkotte, Tanja G. M. and Vrijheid, Martine and de Geus, Eco J. C. N. and Hayes, M. Geoffrey and Kadarmideen, Haja N. and Holm, Jens-Christian and Beilin, Lawrence J. and Pennell, Craig E. and Heinrich, Joachim and Adair, Linda S. and Borja, Judith B. and Mohlke, Karen L. and Eriksson, Johan G. and Widen, Elisabeth E. and Hattersley, Andrew T. and Spector, Tim D. and Kaehoenen, Mika and Viikari, Jorma S. and Lehtimaeki, Terho and Boomsma, Dorret I. and Sebert, Sylvain and Vollenweider, Peter and Sorensen, Thorkild I. A. and Bisgaard, Hans and Bonnelykke, Klaus and Murray, Jeffrey C. and Melbye, Mads and Nohr, Ellen A. and Mook-Kanamori, Dennis O. and Rivadeneira, Fernando and Hofman, Albert and Felix, Janine F. and Jaddoe, Vincent W. V. and Hansen, Torben and Pisinger, Charlotta and Vaag, Allan A. and Pedersen, Oluf and Uitterlinden, Andre G. and Jarvelin, Marjo-Riitta and Power, Christine and Hypponen, Elina and Scholtens, Denise M. and Lowe, William L. and Smith, George Davey and Timpson, Nicholas J. and Morris, Andrew P. and Wareham, Nicholas J. and Hakonarson, Hakon and Grant, Struan F. A. and Frayling, Timothy M. and Lawlor, Debbie A. and Njolstad, Pal R. and Johansson, Stefan and Ong, Ken K. and McCarthy, Mark I. and Perry, John R. B. and Evans, David M. and Freathy, Rachel M.},
  title     = {Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors},
  series = {Nature genetics},
  volume    = {51},
  journal   = {Nature genetics},
  number    = {5},
  publisher = {Nature Publ. Group},
  address   = {New York},
  organization    = {EGG Consortium},
  issn      = {1061-4036},
  pages     = {804 -- +},
  year      = {2019},
  abstract  = {Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.},
  language  = {en}
}
@article{ZwickelKahlKlaffkeetal.2016,
  author    = {Zwickel, Theresa and Kahl, Sandra M. and Klaffke, Horst and Rychlik, Michael and M{\"u}ller, Marina E. H.},
  title     = {Spotlight on the Underdogs-An Analysis of Underrepresented Alternaria Mycotoxins Formed Depending on Varying Substrate, Time and Temperature Conditions},
  series = {Toxins},
  volume    = {8},
  journal   = {Toxins},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2072-6651},
  doi       = {10.3390/toxins8110344},
  pages     = {570 -- 583},
  year      = {2016},
  abstract  = {Alternaria (A.) is a genus of widespread fungi capable of producing numerous, possibly health-endangering Alternaria toxins (ATs), which are usually not the focus of attention. The formation of ATs depends on the species and complex interactions of various environmental factors and is not fully understood. In this study the influence of temperature (7 degrees C, 25 degrees C), substrate (rice, wheat kernels) and incubation time (4, 7, and 14 days) on the production of thirteen ATs and three sulfoconjugated ATs by three different Alternaria isolates from the species groups A. tenuissima and A. infectoria was determined. High-performance liquid chromatography coupled with tandem mass spectrometry was used for quantification. Under nearly all conditions, tenuazonic acid was the most extensively produced toxin. At 25 degrees C and with increasing incubation time all toxins were formed in high amounts by the two A. tenuissima strains on both substrates with comparable mycotoxin profiles. However, for some of the toxins, stagnation or a decrease in production was observed from day 7 to 14. As opposed to the A. tenuissima strains, the A. infectoria strain only produced low amounts of ATs, but high concentrations of stemphyltoxin III. The results provide an essential insight into the quantitative in vitro AT formation under different environmental conditions, potentially transferable to different field and storage conditions.},
  language  = {en}
}
@article{ZwickelKahlRychliketal.2018,
  author    = {Zwickel, Theresa and Kahl, Sandra M. and Rychlik, Michael and M{\"u}ller, Marina E. H.},
  title     = {Chemotaxonomy of Mycotoxigenic Small-Spored Alternaria Fungi},
  series = {Frontiers in microbiology},
  volume    = {9},
  journal   = {Frontiers in microbiology},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-302X},
  doi       = {10.3389/fmicb.2018.01368},
  pages     = {20},
  year      = {2018},
  abstract  = {Necrotrophic as well as saprophytic small-spored Altemaria (A.) species are annually responsible for major losses of agricultural products, such as cereal crops, associated with the contamination of food and feedstuff with potential health-endangering Altemaria toxins. Knowledge of the metabolic capabilities of different species-groups to form mycotoxins is of importance for a reliable risk assessment. 93 Altemaria strains belonging to the four species groups Alternaria tenuissima, A. arborescens, A. altemata, and A. infectoria were isolated from winter wheat kernels harvested from fields in Germany and Russia and incubated under equal conditions. Chemical analysis by means of an HPLC-MS/MS multi-Alternaria-toxin-method showed that 95\% of all strains were able to form at least one of the targeted 17 non-host specific Altemaria toxins. Simultaneous production of up to 15 (modified) Altemaria toxins by members of the A. tenuissima, A. arborescens, A. altemata species-groups and up to seven toxins by A. infectoria strains was demonstrated. Overall tenuazonic acid was the most extensively formed mycotoxin followed by alternariol and alternariol mono methylether, whereas altertoxin I was the most frequently detected toxin. Sulfoconjugated modifications of alternariol, alternariol mono methylether, altenuisol and altenuene were frequently determined. Unknown perylene quinone derivatives were additionally detected. Strains of the species-group A. infectoria could be segregated from strains of the other three species-groups due to significantly lower toxin levels and the specific production of infectopyrone. Apart from infectopyrone, alterperylenol was also frequently produced by 95\% of the A. infectoria strains. Neither by the concentration nor by the composition of the targeted Altemaria toxins a differentiation between the species-groups A. altemata, A. tenuissima and A. arborescens was possible.},
  language  = {en}
}