@article{VogelKamitzHallahanetal.2018, author = {Vogel, Heike and Kamitz, Anne and Hallahan, Nicole and Lebek, Sandra and Schallschmidt, Tanja and Jonas, Wenke and J{\"a}hnert, Markus and Gottmann, Pascal and Zellner, Lisa and Kanzleiter, Timo and Damen, Mareike and Altenhofen, Delsi and Burkhardt, Ralph and Renner, Simone and Dahlhoff, Maik and Wolf, Eckhard and M{\"u}ller, Timo Dirk and Bl{\"u}her, Matthias and Joost, Hans-Georg and Chadt, Alexandra and Al-Hasani, Hadi and Sch{\"u}rmann, Annette}, title = {A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and Type 2 diabetes}, series = {Human molecular genetics}, volume = {27}, journal = {Human molecular genetics}, number = {17}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0964-6906}, doi = {10.1093/hmg/ddy217}, pages = {3099 -- 3112}, year = {2018}, abstract = {To explore the genetic determinants of obesity and Type 2 diabetes (T2D), the German Center for Diabetes Research (DZD) conducted crossbreedings of the obese and diabetes-prone New Zealand Obese mouse strain with four different lean strains (B6, DBA, C3H, 129P2) that vary in their susceptibility to develop T2D. Genome-wide linkage analyses localized more than 290 quantitative trait loci (QTL) for obesity, 190 QTL for diabetes-related traits and 100 QTL for plasma metabolites in the out-cross populations. A computational framework was developed that allowed to refine critical regions and to nominate a small number of candidate genes by integrating reciprocal haplotype mapping and transcriptome data. The efficiency of the complex procedure was demonstrated for one obesity QTL. The genomic interval of 35 Mb with 502 annotated candidate genes was narrowed down to six candidates. Accordingly, congenic mice retained the obesity phenotype owing to an interval that contains three of the six candidate genes. Among these the phospholipase PLA2G4A exhibited an elevated expression in adipose tissue of obese human subjects and is therefore a critical regulator of the obesity locus. Together, our broad and complex approach demonstrates that combined- and comparative-cross analysis exhibits improved mapping resolution and represents a valid tool for the identification of disease genes.}, language = {en} } @article{Mueller2013, author = {M{\"u}ller, Dirk}, title = {Fasten und Feiern in altrussischen Kl{\"o}stern}, series = {Russische K{\"u}che und kulturelle Identit{\"a}t}, journal = {Russische K{\"u}che und kulturelle Identit{\"a}t}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-68044}, pages = {303 -- 320}, year = {2013}, language = {de} } @article{SramaAhrensAltobellietal.2004, author = {Srama, Ralf and Ahrens, Thomas J. and Altobelli, Nicolas and Auer, S. and Bradley, J. G. and Burton, M. and Dikarev, V. V. and Economou, T. and Fechtig, Hugo and G{\"o}rlich, M. and Grande, M. and Graps, Amara and Gr{\"u}n, Eberhard and Havnes, Ove and Helfert, Stefan and Horanyi, Mihaly and Igenbergs, E. and Jessberger, Elmar K. and Johnson, T. V. and Kempf, Sascha and Krivov, Alexander v. and Kr{\"u}ger, Harald and Mocker-Ahlreep, Anna and Moragas-Klostermeyer, Georg and Lamy, Philippe and Landgraf, Markus and Linkert, Dietmar and Linkert, G. and Lura, F. and McDonnell, J. A. M. and Moehlmann, Dirk and Morfill, Gregory E. and Muller, M. and Roy, M. and Schafer, G. and Schlotzhauer, G. and Schwehm, Gerhard H. and Spahn, Frank and St{\"u}big, M. and Svestka, Jiri and Tschernjawski, V}, title = {The Cassini Cosmic Dust Analyzer}, issn = {0038-6308}, year = {2004}, abstract = {The Cassini-Huygens Cosmic Dust Analyzer (CDA) is intended to provide direct observations of dust grains with masses between 10(-19) and 10(-9) kg in interplanetary space and in the jovian and saturnian systems, to investigate their physical, chemical and dynamical properties as functions of the distances to the Sun, to Jupiter and to Saturn and its satellites and rings, to study their interaction with the saturnian rings, satellites and magnetosphere. Chemical composition of interplanetary meteoroids will be compared with asteroidal and cometary dust, as well as with Saturn dust, ejecta from rings and satellites. Ring and satellites phenomena which might be effects of meteoroid impacts will be compared with the interplanetary dust environment. Electrical charges of particulate matter in the magnetosphere and its consequences will be studied, e.g. the effects of the ambient plasma and the magnetic held on the trajectories of dust particles as well as fragmentation of particles due to electrostatic disruption. The investigation will be performed with an instrument that measures the mass, composition, electric charge, speed, and flight direction of individual dust particles. It is a highly reliable and versatile instrument with a mass sensitivity 106 times higher than that of the Pioneer 10 and I I dust detectors which measured dust in the saturnian system. The Cosmic Dust Analyzer has significant inheritance from former space instrumentation developed for the VEGA, Giotto, Galileo, and Ulysses missions. It will reliably measure impacts from as low as I impact per month up to 104 impacts per second. The instrument weighs 17 kg and consumes 12 W, the integrated time-of-flight mass spectrometer has a mass resolution of up to 50. The nominal data transmission rate is 524 bits/s and varies between 50 and 4192 bps}, language = {en} } @phdthesis{MuellerWohlfeil2001, author = {M{\"u}ller-Wohlfeil, Dirk-Ingmar}, title = {Model frameworks for the calculation of annual runoff and nitrogen emission from danish catchments}, pages = {104 S.}, year = {2001}, language = {en} } @article{VoelkerGomezPorrasBeckeretal.2010, author = {Voelker, Camilla and Gomez-Porras, Judith Lucia and Becker, Dirk and Hamamoto, Shin and Uozumi, Nobuyuki and Gambale, Franco and M{\"u}ller-R{\"o}ber, Bernd and Czempinski, Katrin and Dreyer, Ingo}, title = {Roles of tandem-pore K plus channels in plants : a puzzle still to be solved}, issn = {1435-8603}, doi = {10.1111/j.1438-8677.2010.00353.x}, year = {2010}, abstract = {The group of voltage-independent K+ channels in Arabidopsis thaliana consists of six members, five tandem-pore channels (TPK1-TPK5) and a single K-ir-like channel (KCO3). All TPK/KCO channels are located at the vacuolar membrane except for TPK4, which was shown to be a plasma membrane channel in pollen. The vacuolar channels interact with 14-3-3 proteins (also called General Regulating Factors, GRFs), indicating regulation at the level of protein-protein interactions. Here we review current knowledge about these ion channels and their genes, and highlight open questions that need to be urgently addressed in future studies to fully appreciate the physiological functions of these ion channels.}, language = {en} } @article{ProostVanBelVaneechoutteetal.2015, author = {Proost, Sebastian and Van Bel, Michiel and Vaneechoutte, Dries and Van de Peer, Yves and Inze, Dirk and M{\"u}ller-R{\"o}ber, Bernd and Vandepoele, Klaas}, title = {PLAZA 3.0: an access point for plant comparative genomics}, series = {Nucleic acids research}, volume = {43}, journal = {Nucleic acids research}, number = {D1}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0305-1048}, doi = {10.1093/nar/gku986}, pages = {D974 -- D981}, year = {2015}, abstract = {Comparative sequence analysis has significantly altered our view on the complexity of genome organization and gene functions in different kingdoms. PLAZA 3.0 is designed to make comparative genomics data for plants available through a user-friendly web interface. Structural and functional annotation, gene families, protein domains, phylogenetic trees and detailed information about genome organization can easily be queried and visualized. Compared with the first version released in 2009, which featured nine organisms, the number of integrated genomes is more than four times higher, and now covers 37 plant species. The new species provide a wider phylogenetic range as well as a more in-depth sampling of specific clades, and genomes of additional crop species are present. The functional annotation has been expanded and now comprises data from Gene Ontology, MapMan, UniProtKB/Swiss-Prot, PlnTFDB and PlantTFDB. Furthermore, we improved the algorithms to transfer functional annotation from well-characterized plant genomes to other species. The additional data and new features make PLAZA 3.0 (http://bioinformatics.psb.ugent.be/plaza/) a versatile and comprehensible resource for users wanting to explore genome information to study different aspects of plant biology, both in model and non-model organisms.}, language = {en} } @article{BeckerGeigerDunkeletal.2004, author = {Becker, Dirk and Geiger, D. and Dunkel, M. and Roller, A. and Bertl, Adam and Latz, A. and Carpaneto, Armando and Dietrich, Peter and Roelfsema, M. R. G. and Voelker, C. and Schmidt, D. and M{\"u}ller-R{\"o}ber, Bernd and Czempinski, Katrin and Hedrich, R.}, title = {AtTPK4, an Arabidopsis tandem-pore K+ channel, poised to control the pollen membrane voltage in a pH- and Ca2+- dependent manner}, issn = {0027-8424}, year = {2004}, abstract = {The Arabidopsis tandem-pore K+ (TPK) channels displaying four transmembrane domains and two pore regions share structural homologies with their animal counterparts of the KCNK family. In contrast to the Shaker-like Arabidopsis channels (six transmembrane domains/one pore region), the functional properties and the biological role of plant TPK channels have not been elucidated yet. Here, we show that AtTPK4 (KCO4) localizes to the plasma membrane and is predominantly expressed in pollen. AtTPK4 (KCO4) resembles the electrical properties of a voltage-independent K+ channel after expression in Xenopus oocytes and yeast. Hyperpolarizing as well as depolarizing membrane voltages elicited instantaneous K+ currents, which were blocked by extracellular calcium and cytoplasmic protons. Functional complementation assays using a K+ transport-deficient yeast confirmed the biophysical and pharmacological properties of the AtTPK4 channel. The features of AtTPK4 point toward a role in potassium homeostasis and membrane voltage control of the growing pollen tube. Thus, AtTPK4 represents a member of plant tandem-pore-K+ channels, resembling the characteristics of its animal counterparts as well as plant-specific features with respect to modulation of channel activity by acidosis and calcium}, language = {en} } @book{SchwarzerWeissSaoumiKitteletal.2023, author = {Schwarzer, Ingo and Weiß-Saoumi, Said and Kittel, Roland and Friedrich, Tobias and Kaynak, Koraltan and Durak, Cemil and Isbarn, Andreas and Diestel, J{\"o}rg and Knittel, Jens and Franz, Marquart and Morra, Carlos and Stahnke, Susanne and Braband, Jens and Dittmann, Johannes and Griebel, Stephan and Krampf, Andreas and Link, Martin and M{\"u}ller, Matthias and Radestock, Jens and Strub, Leo and Bleeke, Kai and Jehl, Leander and Kapitza, R{\"u}diger and Messadi, Ines and Schmidt, Stefan and Schwarz-R{\"u}sch, Signe and Pirl, Lukas and Schmid, Robert and Friedenberger, Dirk and Beilharz, Jossekin Jakob and Boockmeyer, Arne and Polze, Andreas and R{\"o}hrig, Ralf and Sch{\"a}be, Hendrik and Thiermann, Ricky}, title = {RailChain}, number = {152}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-86956-550-7}, issn = {1613-5652}, doi = {10.25932/publishup-57740}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-577409}, publisher = {Universit{\"a}t Potsdam}, pages = {140}, year = {2023}, abstract = {The RailChain project designed, implemented, and experimentally evaluated a juridical recorder that is based on a distributed consensus protocol. That juridical blockchain recorder has been realized as distributed ledger on board the advanced TrainLab (ICE-TD 605 017) of Deutsche Bahn. For the project, a consortium consisting of DB Systel, Siemens, Siemens Mobility, the Hasso Plattner Institute for Digital Engineering, Technische Universit{\"a}t Braunschweig, T{\"U}V Rheinland InterTraffic, and Spherity has been formed. These partners not only concentrated competencies in railway operation, computer science, regulation, and approval, but also combined experiences from industry, research from academia, and enthusiasm from startups. Distributed ledger technologies (DLTs) define distributed databases and express a digital protocol for transactions between business partners without the need for a trusted intermediary. The implementation of a blockchain with real-time requirements for the local network of a railway system (e.g., interlocking or train) allows to log data in the distributed system verifiably in real-time. For this, railway-specific assumptions can be leveraged to make modifications to standard blockchains protocols. EULYNX and OCORA (Open CCS On-board Reference Architecture) are parts of a future European reference architecture for control command and signalling (CCS, Reference CCS Architecture - RCA). Both architectural concepts outline heterogeneous IT systems with components from multiple manufacturers. Such systems introduce novel challenges for the approved and safety-relevant CCS of railways which were considered neither for road-side nor for on-board systems so far. Logging implementations, such as the common juridical recorder on vehicles, can no longer be realized as a central component of a single manufacturer. All centralized approaches are in question. The research project RailChain is funded by the mFUND program and gives practical evidence that distributed consensus protocols are a proper means to immutably (for legal purposes) store state information of many system components from multiple manufacturers. The results of RailChain have been published, prototypically implemented, and experimentally evaluated in large-scale field tests on the advanced TrainLab. At the same time, the project showed how RailChain can be integrated into the road-side and on-board architecture given by OCORA and EULYNX. Logged data can now be analysed sooner and also their trustworthiness is being increased. This enables, e.g., auditable predictive maintenance, because it is ensured that data is authentic and unmodified at any point in time.}, language = {en} } @article{MeierKrauzePrateretal.2019, author = {Meier, Lars A. and Krauze, Patryk and Prater, Isabel and Horn, Fabian and Schaefer, Carlos Ernesto Reynaud and Scholten, Thomas and Wagner, Dirk and M{\"u}ller, Carsten Werner and K{\"u}hn, Peter}, title = {Pedogenic and microbial interrelation in initial soils under semiarid climate on James Ross Island, Antarctic Peninsula region}, series = {Biogeosciences}, volume = {16}, journal = {Biogeosciences}, number = {12}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {1726-4170}, doi = {10.5194/bg-16-2481-2019}, pages = {2481 -- 2499}, year = {2019}, abstract = {James Ross Island (JRI) offers the exceptional opportunity to study microbial-driven pedogenesis without the influence of vascular plants or faunal activities (e.g., penguin rookeries). In this study, two soil profiles from JRI (one at Santa Martha Cove - SMC, and another at Brandy Bay BB) were investigated, in order to gain information about the initial state of soil formation and its interplay with prokaryotic activity, by combining pedological, geochemical and microbiological methods. The soil profiles are similar with respect to topographic position and parent material but are spatially separated by an orographic barrier and therefore represent windward and leeward locations towards the mainly southwesterly winds. These different positions result in differences in electric conductivity of the soils caused by additional input of bases by sea spray at the windward site and opposing trends in the depth functions of soil pH and electric conductivity. Both soils are classified as Cryosols, dominated by bacterial taxa such as Actinobacteria, Proteobacteria, Acidobacteria, Gemmatimonadetes and Chloroflexi. A shift in the dominant taxa was observed below 20 cm in both soils as well as an increased abundance of multiple operational taxonomic units (OTUs) related to potential chemolithoautotrophic Acidiferrobacteraceae. This shift is coupled by a change in microstructure. While single/pellicular grain microstructure (SMC) and platy microstructure (BB) are dominant above 20 cm, lenticular microstructure is dominant below 20 cm in both soils. The change in microstructure is caused by frequent freeze-thaw cycles and a relative high water content, and it goes along with a development of the pore spacing and is accompanied by a change in nutrient content. Multivariate statistics revealed the influence of soil parameters such as chloride, sulfate, calcium and organic carbon contents, grain size distribution and pedogenic oxide ratios on the overall microbial community structure and explained 49.9\% of its variation. The correlation of the pedogenic oxide ratios with the compositional distribution of microorganisms as well as the relative abundance certain microorganisms such as potentially chemolithotrophic Acidiferrobacteraceae-related OTUs could hint at an interplay between soil-forming processes and microorganisms.}, language = {en} } @article{MuellervanSchaikBlumeetal.2014, author = {M{\"u}ller, Eva Nora and van Schaik, Loes and Blume, Theresa and Bronstert, Axel and Carus, Jana and Fleckenstein, Jan H. and Fohrer, Nicola and Geissler, Katja and Gerke, Horst H. and Gr{\"a}ff, Thomas and Hesse, Cornelia and Hildebrandt, Anke and H{\"o}lker, Franz and Hunke, Philip and K{\"o}rner, Katrin and Lewandowski, J{\"o}rg and Lohmann, Dirk and Meinikmann, Karin and Schibalski, Anett and Schmalz, Britta and Schr{\"o}der-Esselbach, Boris and Tietjen, Britta}, title = {Scales, key aspects, feedbacks and challenges of ecohydrological research in Germany}, series = {Hydrologie und Wasserbewirtschaftung}, volume = {58}, journal = {Hydrologie und Wasserbewirtschaftung}, number = {4}, publisher = {Bundesanst. f{\"u}r Gew{\"a}sserkunde}, address = {Koblenz}, issn = {1439-1783}, doi = {10.5675/HyWa_2014,4_2}, pages = {221 -- 240}, year = {2014}, abstract = {Ecohydrology analyses the interactions of biotic and abiotic aspects of our ecosystems and landscapes. It is a highly diverse discipline in terms of its thematic and methodical research foci. This article gives an overview of current German ecohydrological research approaches within plant-animal-soil-systems, meso-scale catchments and their river networks, lake systems, coastal areas and tidal rivers. It discusses their relevant spatial and temporal process scales and different types of interactions and feedback dynamics between hydrological and biotic processes and patterns. The following topics are considered key challenges: innovative analysis of the interdisciplinary scale continuum, development of dynamically coupled model systems, integrated monitoring of coupled processes at the interface and transition from basic to applied ecohydrological science to develop sustainable water and land resource management strategies under regional and global change.}, language = {de} } @article{ReitenbachGeigerWangetal.2023, author = {Reitenbach, Julija and Geiger, Christina and Wang, Peixi and Vagias, Apostolos N. and Cubitt, Robert and Schanzenbach, Dirk and Laschewsky, Andr{\´e} and Papadakis, Christine M. and M{\"u}ller-Buschbaum, Peter}, title = {Effect of magnesium salts with chaotropic anions on the swelling behavior of PNIPMAM thin films}, series = {Macromolecules : a publication of the American Chemical Society}, volume = {56}, journal = {Macromolecules : a publication of the American Chemical Society}, number = {2}, publisher = {American Chemical Society}, address = {Washington}, issn = {0024-9297}, doi = {10.1021/acs.macromol.2c02282}, pages = {567 -- 577}, year = {2023}, abstract = {Poly(N-isopropylmethacrylamide) (PNIPMAM) is a stimuli responsive polymer, which in thin film geometry exhibits a volume-phase transition upon temperature increase in water vapor. The swelling behavior of PNIPMAM thin films containing magnesium salts in water vapor is investigated in view of their potential application as nanodevices. Both the extent and the kinetics of the swelling ratio as well as the water content are probed with in situ time-of-flight neutron reflectometry. Additionally, in situ Fourier-transform infrared (FTIR) spectroscopy provides information about the local solvation of the specific functional groups, while two-dimensional FTIR correlation analysis further elucidates the temporal sequence of solvation events. The addition of Mg(ClO4)2 or Mg(NO3)2 enhances the sensitivity of the polymer and therefore the responsiveness of switches and sensors based on PNIPMAM thin films. It is found that Mg(NO3)2 leads to a higher relative water uptake and therefore achieves the highest thickness gain in the swollen state.}, language = {en} } @article{HildebrandHeydenreichLaschewskyetal.2017, author = {Hildebrand, Viet and Heydenreich, Matthias and Laschewsky, Andre and Moeller, Heiko M. and M{\"u}ller-Buschbaum, Peter and Papadakis, Christine M. and Schanzenbach, Dirk and Wischerhoff, Erik}, title = {"Schizophrenic" self-assembly of dual thermoresponsive block copolymers bearing a zwitterionic and a non-ionic hydrophilic block}, series = {Polymer : the international journal for the science and technology of polymers}, volume = {122}, journal = {Polymer : the international journal for the science and technology of polymers}, publisher = {Elsevier}, address = {Oxford}, issn = {0032-3861}, doi = {10.1016/j.polymer.2017.06.063}, pages = {347 -- 357}, year = {2017}, abstract = {Several series of presumed dual thermo-responsive diblock copolymers consisting of one non-ionic and one zwitterionic block were synthesized via consecutive reversible addition-fragmentation chain transfer (RAFT) polymerization. For all copolymers, poly(N-isopropylmethacrylamide) was chosen as non-ionic block that shows a coil-to-globule collapse transition of the lower critical solution temperature (LCST) type. In contrast, the chemical structure of zwitterionic blocks, which all belonged to the class of poly(sulfobetaine methacrylate)s, was varied broadly, in order to tune their coil-to-globule collapse transition of the upper critical solution temperature (UCST) type. All polymers were labeled with a solvatochromic fluorescent end-group. The dual thermo-responsive behavior and the resulting multifarious temperature-dependent self-assembly in aqueous solution were mapped by temperature resolved turbidimetry, H-1 NMR spectroscopy, dynamic light scattering (DLS), and fluorescence spectroscopy. Depending on the relative positions between the UCST-type and LCST-type transition temperatures, as well as on the width of the window in-between, all the four possible modes of stimulus induced micellization can be realized. This includes classical induced micellization due to a transition from a double hydrophilic, or respectively, from a double hydrophobic to an amphiphilic state, as well as "schizophrenic" behavior, where the core- and shell-forming blocks are inverted. The exchange of the roles of the hydrophilic and hydrophobic block in the amphiphilic states is possible through a homogeneous intermediate state or a heterogeneous one. (C) 2017 Elsevier Ltd. All rights reserved.}, language = {en} }