@article{StoesselSchultedosSantosetal.2018,
  author    = {Stoessel, Daniel and Schulte, Claudia and dos Santos, Marcia C. Teixeira and Scheller, Dieter and Rebollo-Mesa, Irene and Deuschle, Christian and Walther, Dirk and Schauer, Nicolas and Berg, Daniela and da Costa, Andre Nogueira and Maetzler, Walter},
  title     = {Promising Metabolite Profiles in the Plasma and CSF of Early Clinical},
  series = {Frontiers in Aging Neuroscience},
  volume    = {10},
  journal   = {Frontiers in Aging Neuroscience},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1663-4365},
  doi       = {10.3389/fnagi.2018.00051},
  pages     = {14},
  year      = {2018},
  abstract  = {Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging and rests entirely on clinical features. Thus, there is an urgent need for robust diagnostic biofluid markers. Untargeted metabolomics allows establishing low-molecular compound biomarkers in a wide range of complex diseases by the measurement of various molecular classes in biofluids such as blood plasma, serum, and cerebrospinal fluid (CSF). Here, we applied untargeted high-resolution mass spectrometry to determine plasma and CSF metabolite profiles. We semiquantitatively determined small-molecule levels (<= 1.5 kDa) in the plasma and CSF from early PD patients (disease duration 0-4 years; n = 80 and 40, respectively), and sex-and age-matched controls (n = 76 and 38, respectively). We performed statistical analyses utilizing partial least square and random forest analysis with a 70/30 training and testing split approach, leading to the identification of 20 promising plasma and 14 CSF metabolites. The semetabolites differentiated the test set with an AUC of 0.8 (plasma) and 0.9 (CSF). Characteristics of the metabolites indicate perturbations in the glycerophospholipid, sphingolipid, and amino acid metabolism in PD, which underscores the high power of metabolomic approaches. Further studies will enable to develop a potential metabolite-based biomarker panel specific for PD},
  language  = {en}
}
@misc{FerenzPeterBerg1983,
  author    = {Ferenz, Hans-J{\"u}rgen and Peter, Martin G. and Berg, Dieter},
  title     = {Inhibition of farnesoic acid methyltransferase by sinefungin},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-17016},
  year      = {1983},
  abstract  = {Sinefungin inhibited the S-adenosylmethionine-dependent farnesoic acid methyltransferase in a cell-free system containing a homogenate of corpora allata from female locusts, Locusta migratoria. The enzyme catalyzed the penultimate step of juvenile hormone biosynthesis in the insects. Culturing corpora allata in the presence of sinefungin greatly suppressed juvenile hormone production. The following in vivo effects were visible after injection of the inhibitor: increase in mortality and reduction of total haemolymph protein liter and ovary fresh weight, as well as length of terminal oocytes. Attempts to reverse these effects by topical application of the juvenile hormone analog ZR-515 (methoprene) were only partly successful. Therefore, the in vivo effects may be due to a general inhibition of methyltransferase enzymes in the insect. Sinefungin appeared to be of potential interest as the first representative of a new class of insect growth regulators.},
  language  = {en}
}
@inproceedings{HeinischRomeikeKnobelsdorfetal.2013,
  author    = {Heinisch, Isabelle and Romeike, Ralf and Knobelsdorf, Maria and Kreitz, Christoph and Nyl{\´e}n, Aletta and D{\"o}rge, Christina and G{\"o}ttel, Timo and Holz, Jan and Bergner, Nadine and Schroeder, Ulrik and Metzger, Christiane and Haag, Johann and Abke, J{\"o}rg and Schwirtlich, Vincent and Sedelmaier, Yvonne and M{\"u}ller, Dorothee and Frommer, Andreas and Humbert, Ludger and Berges, Marc and M{\"u}hling, Andreas and Hubwieser, Peter and Steuer, Horst and Engbring, Dieter and Selke, Harald and Drews, Paul and Schirmer, Ingrid and Morisse, Marcel and Sagawe, Arno and Rolf, Arno and Friedemann, Stefan and Gr{\"o}ger, Stefan and Schumann, Matthias and Klinger, Melanie and Polutina, Olena and Bibel, Ariane and G{\"o}tz, Christian and Brinda, Torsten and Apel, Rebecca and Berg, Tobias and Bergner, Nadine and Chatti, Mohamed Amine and Leicht-Scholten, Carmen and Schroeder, Ulrik and Al-Saffar, Loay Talib and Petre, Marian and Schirmer, Ingrid and Rick, Detlef},
  title     = {HDI 2012 - Informatik f{\"u}r eine nachhaltige Zukunft : 5. Fachtagung Hochschuldidaktik der Informatik ; 06.-07. November 2012, Universit{\"a}t Hamburg},
  editor    = {Forbrig, Peter and Rick, Detlef and Schmolitzky, Axel},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-220-9},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-62891},
  pages     = {169},
  year      = {2013},
  abstract  = {Die Tagungsreihe zur Hochschuldidaktik der Informatik HDI wird vom Fachbereich Informatik und Ausbildung / Didaktik der Informatik (IAD) in der Gesellschaft f{\"u}r Informatik e. V. (GI) organisiert. Sie dient den Lehrenden der Informatik in Studieng{\"a}ngen an Hochschulen als Forum der Information und des Austauschs {\"u}ber neue didaktische Ans{\"a}tze und bildungspolitische Themen im Bereich der Hochschulausbildung aus der fachlichen Perspektive der Informatik. Diese f{\"u}nfte HDI 2012 wurde an der Universit{\"a}t Hamburg organisiert. F{\"u}r sie wurde das spezielle Motto „Informatik f{\"u}r eine nachhaltige Zukunft" gew{\"a}hlt, um insbesondere Fragen der Bildungsrelevanz informatischer Inhalte, der Kompetenzen f{\"u}r Studierende informatisch gepr{\"a}gter Studieng{\"a}nge und der Rolle der Informatik in der Hochschulentwicklung zu diskutieren.},
  language  = {de}
}