@article{ActisAgnettaAharonianetal.2011,
  author    = {Actis, M. and Agnetta, G. and Aharonian, Felix A. and Akhperjanian, A. G. and Aleksic, J. and Aliu, E. and Allan, D. and Allekotte, I. and Antico, F. and Antonelli, L. A. and Antoranz, P. and Aravantinos, A. and Arlen, T. and Arnaldi, H. and Artmann, S. and Asano, K. and Asorey, H. G. and Baehr, J. and Bais, A. and Baixeras, C. and Bajtlik, S. and Balis, D. and Bamba, A. and Barbier, C. and Barcelo, M. and Barnacka, Anna and Barnstedt, J{\"u}rgen and de Almeida, U. Barres and Barrio, J. A. and Basso, S. and Bastieri, D. and Bauer, C. and Becerra Gonzalez, J. and Becherini, Yvonne and Bechtol, K. C. and Becker, J. and Beckmann, Volker and Bednarek, W. and Behera, B. and Beilicke, M. and Belluso, M. and Benallou, M. and Benbow, W. and Berdugo, J. and Berger, K. and Bernardino, T. and Bernl{\"o}hr, K. and Biland, A. and Billotta, S. and Bird, T. and Birsin, E. and Bissaldi, E. and Blake, S. and Blanch Bigas, O. and Bobkov, A. A. and Bogacz, L. and Bogdan, M. and Boisson, Catherine and Boix Gargallo, J. and Bolmont, J. and Bonanno, G. and Bonardi, A. and Bonev, T. and Borkowski, Janett and Botner, O. and Bottani, A. and Bourgeat, M. and Boutonnet, C. and Bouvier, A. and Brau-Nogue, S. and Braun, I. and Bretz, T. and Briggs, M. S. and Brun, Pierre and Brunetti, L. and Buckley, H. and Bugaev, V. and Buehler, R. and Bulik, Tomasz and Busetto, G. and Buson, S. and Byrum, K. and Cailles, M. and Cameron, R. A. and Canestrari, R. and Cantu, S. and Carmona, E. and Carosi, A. and Carr, John and Carton, P. H. and Casiraghi, M. and Castarede, H. and Catalano, O. and Cavazzani, S. and Cazaux, S. and Cerruti, B. and Cerruti, M. and Chadwick, M. and Chiang, J. and Chikawa, M. and Cieslar, M. and Ciesielska, M. and Cillis, A. N. and Clerc, C. and Colin, P. and Colome, J. and Compin, M. and Conconi, P. and Connaughton, V. and Conrad, Jan and Contreras, J. L. and Coppi, P. and Corlier, M. and Corona, P. and Corpace, O. and Corti, D. and Cortina, J. and Costantini, H. and Cotter, G. and Courty, B. and Couturier, S. and Covino, S. and Croston, J. and Cusumano, G. and Daniel, M. K. and Dazzi, F. and Deangelis, A. and de Cea del Pozo, E. and Dal Pino, E. M. de Gouveia and de Jager, O. and de la Calle Perez, I. and De La Vega, G. and De Lotto, B. and de Naurois, M. and Wilhelmi, E. de Ona and de Souza, V. and Decerprit, B. and Deil, C. and Delagnes, E. and Deleglise, G. and Delgado, C. and Dettlaff, T. and Di Paolo, A. and Di Pierro, F. and Diaz, C. and Dick, J. and Dickinson, H. and Digel, S. W. and Dimitrov, D. and Disset, G. and Djannati-Ata{\"i}, A. and Doert, M. and Domainko, W. and Dorner, D. and Doro, M. and Dournaux, J. -L. and Dravins, D. and Drury, L. and Dubois, F. and Dubois, R. and Dubus, G. and Dufour, C. and Durand, D. and Dyks, J. and Dyrda, M. and Edy, E. and Egberts, Kathrin and Eleftheriadis, C. and Elles, S. and Emmanoulopoulos, D. and Enomoto, R. and Ernenwein, J. -P. and Errando, M. and Etchegoyen, A. and Falcone, A. D. and Farakos, K. and Farnier, C. and Federici, S. and Feinstein, F. and Ferenc, D. and Fillin-Martino, E. and Fink, D. and Finley, C. and Finley, J. P. and Firpo, R. and Florin, D. and Foehr, C. and Fokitis, E. and Font, Ll. and Fontaine, G. and Fontana, A. and Foerster, A. and Fortson, L. and Fouque, N. and Fransson, C. and Fraser, G. W. and Fresnillo, L. and Fruck, C. and Fujita, Y. and Fukazawa, Y. and Funk, S. and Gaebele, W. and Gabici, S. and Gadola, A. and Galante, N. and Gallant, Y. and Garcia, B. and Garcia Lopez, R. J. and Garrido, D. and Garrido, L. and Gascon, D. and Gasq, C. and Gaug, M. and Gaweda, J. and Geffroy, N. and Ghag, C. and Ghedina, A. and Ghigo, M. and Gianakaki, E. and Giarrusso, S. and Giavitto, G. and Giebels, B. and Giro, E. and Giubilato, P. and Glanzman, T. and Glicenstein, J. -F. and Gochna, M. and Golev, V. and Gomez Berisso, M. and Gonzalez, A. and Gonzalez, F. and Granena, F. and Graciani, R. and Granot, J. and Gredig, R. and Green, A. and Greenshaw, T. and Grimm, O. and Grube, J. and Grudzinska, M. and Grygorczuk, J. and Guarino, V. and Guglielmi, L. and Guilloux, F. and Gunji, S. and Gyuk, G. and Hadasch, D. and Haefner, D. and Hagiwara, R. and Hahn, J. and Hallgren, A. and Hara, S. and Hardcastle, M. J. and Hassan, T. and Haubold, T. and Hauser, M. and Hayashida, M. and Heller, R. and Henri, G. and Hermann, G. and Herrero, A. and Hinton, James Anthony and Hoffmann, D. and Hofmann, W. and Hofverberg, P. and Horns, D. and Hrupec, D. and Huan, H. and Huber, B. and Huet, J. -M. and Hughes, G. and Hultquist, K. and Humensky, T. B. and Huppert, J. -F. and Ibarra, A. and Illa, J. M. and Ingjald, J. and Inoue, S. and Inoue, Y. and Ioka, K. and Jablonski, C. and Jacholkowska, A. and Janiak, M. and Jean, P. and Jensen, H. and Jogler, T. and Jung, I. and Kaaret, P. and Kabuki, S. and Kakuwa, J. and Kalkuhl, C. and Kankanyan, R. and Kapala, M. and Karastergiou, A. and Karczewski, M. and Karkar, S. and Karlsson, N. and Kasperek, J. and Katagiri, H. and Katarzynski, K. and Kawanaka, N. and Kedziora, B. and Kendziorra, E. and Khelifi, B. and Kieda, D. and Kifune, T. and Kihm, T. and Klepser, S. and Kluzniak, W. and Knapp, J. and Knappy, A. R. and Kneiske, T. and Knoedlseder, J. and Koeck, F. and Kodani, K. and Kohri, K. and Kokkotas, K. and Komin, N. and Konopelko, A. and Kosack, K. and Kossakowski, R. and Kostka, P. and Kotula, J. and Kowal, G. and Koziol, J. and Kraehenbuehl, T. and Krause, J. and Krawczynski, H. and Krennrich, F. and Kretzschmann, A. and Kubo, H. and Kudryavtsev, V. A. and Kushida, J. and La Barbera, N. and La Parola, V. and La Rosa, G. and Lopez, A. and Lamanna, G. and Laporte, P. and Lavalley, C. and Le Flour, T. and Le Padellec, A. and Lenain, J. -P. and Lessio, L. and Lieunard, B. and Lindfors, E. and Liolios, A. and Lohse, T. and Lombardi, S. and Lopatin, A. and Lorenz, E. and Lubinski, P. and Luz, O. and Lyard, E. and Maccarone, M. C. and Maccarone, T. and Maier, G. and Majumdar, P. and Maltezos, S. and Malkiewicz, P. and Mana, C. and Manalaysay, A. and Maneva, G. and Mangano, A. and Manigot, P. and Marin, J. and Mariotti, M. and Markoff, S. and Martinez, G. and Martinez, M. and Mastichiadis, A. and Matsumoto, H. and Mattiazzo, S. and Mazin, D. and McComb, T. J. L. and McCubbin, N. and McHardy, I. and Medina, C. and Melkumyan, D. and Mendes, A. and Mertsch, P. and Meucci, M. and Michalowski, J. and Micolon, P. and Mineo, T. and Mirabal, N. and Mirabel, F. and Miranda, J. M. and Mirzoyan, R. and Mizuno, T. and Moal, B. and Moderski, R. and Molinari, E. and Monteiro, I. and Moralejo, A. and Morello, C. and Mori, K. and Motta, G. and Mottez, F. and Moulin, Emmanuel and Mukherjee, R. and Munar, P. and Muraishi, H. and Murase, K. and Murphy, A. Stj. and Nagataki, S. and Naito, T. and Nakamori, T. and Nakayama, K. and Naumann, C. L. and Naumann, D. and Nayman, P. and Nedbal, D. and Niedzwiecki, A. and Niemiec, J. and Nikolaidis, A. and Nishijima, K. and Nolan, S. J. and Nowak, N. and O'Brien, P. T. and Ochoa, I. and Ohira, Y. and Ohishi, M. and Ohka, H. and Okumura, A. and Olivetto, C. and Ong, R. A. and Orito, R. and Orr, M. and Osborne, J. P. and Ostrowski, M. and Otero, L. and Otte, A. N. and Ovcharov, E. and Oya, I. and Ozieblo, A. and Paiano, S. and Pallota, J. and Panazol, J. L. and Paneque, D. and Panter, M. and Paoletti, R. and Papyan, G. and Paredes, J. M. and Pareschi, G. and Parsons, R. D. and Arribas, M. Paz and Pedaletti, G. and Pepato, A. and Persic, M. and Petrucci, P. O. and Peyaud, B. and Piechocki, W. and Pita, S. and Pivato, G. and Platos, L. and Platzer, R. and Pogosyan, L. and Pohl, Martin and Pojmanski, G. and Ponz, J. D. and Potter, W. and Prandini, E. and Preece, R. and Prokoph, H. and Puehlhofer, G. and Punch, M. and Quel, E. and Quirrenbach, A. and Rajda, P. and Rando, R. and Rataj, M. and Raue, M. and Reimann, C. and Reimann, O. and Reimer, A. and Reimer, O. and Renaud, M. and Renner, S. and Reymond, J. -M. and Rhode, W. and Ribo, M. and Ribordy, M. and Rico, J. and Rieger, F. and Ringegni, P. and Ripken, J. and Ristori, P. and Rivoire, S. and Rob, L. and Rodriguez, S. and Roeser, U. and Romano, Patrizia and Romero, G. E. and Rosier-Lees, S. and Rovero, A. C. and Roy, F. and Royer, S. and Rudak, B. and Rulten, C. B. and Ruppel, J. and Russo, F. and Ryde, F. and Sacco, B. and Saggion, A. and Sahakian, V. and Saito, K. and Saito, T. and Sakaki, N. and Salazar, E. and Salini, A. and Sanchez, F. and Sanchez Conde, M. A. and Santangelo, Andrea and Santos, E. M. and Sanuy, A. and Sapozhnikov, L. and Sarkar, S. and Scalzotto, V. and Scapin, V. and Scarcioffolo, M. and Schanz, T. and Schlenstedt, S. and Schlickeiser, R. and Schmidt, T. and Schmoll, J. and Schroedter, M. and Schultz, C. and Schultze, J. and Schulz, A. and Schwanke, U. and Schwarzburg, S. and Schweizer, T. and Seiradakis, J. and Selmane, S. and Seweryn, K. and Shayduk, M. and Shellard, R. C. and Shibata, T. and Sikora, M. and Silk, J. and Sillanpaa, A. and Sitarek, J. and Skole, C. and Smith, N. and Sobczynska, D. and Sofo Haro, M. and Sol, H. and Spanier, F. and Spiga, D. and Spyrou, S. and Stamatescu, V. and Stamerra, A. and Starling, R. L. C. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steiner, S. and Stergioulas, N. and Sternberger, R. and Stinzing, F. and Stodulski, M. and Straumann, U. and Suarez, A. and Suchenek, M. and Sugawara, R. and Sulanke, K. H. and Sun, S. and Supanitsky, A. D. and Sutcliffe, P. and Szanecki, M. and Szepieniec, T. and Szostek, A. and Szymkowiak, A. and Tagliaferri, G. and Tajima, H. and Takahashi, H. and Takahashi, K. and Takalo, L. and Takami, H. and Talbot, R. G. and Tam, P. H. and Tanaka, M. and Tanimori, T. and Tavani, M. and Tavernet, J. -P. and Tchernin, C. and Tejedor, L. A. and Telezhinsky, Igor O. and Temnikov, P. and Tenzer, C. and Terada, Y. and Terrier, R. and Teshima, M. and Testa, V. and Tibaldo, L. and Tibolla, O. and Tluczykont, M. and Peixoto, C. J. Todero and Tokanai, F. and Tokarz, M. and Toma, K. and Torres, D. F. and Tosti, G. and Totani, T. and Toussenel, F. and Vallania, P. and Vallejo, G. and van der Walt, J. and van Eldik, C. and Vandenbroucke, J. and Vankov, H. and Vasileiadis, G. and Vassiliev, V. V. and Vegas, I. and Venter, L. and Vercellone, S. and Veyssiere, C. and Vialle, J. P. and Videla, M. and Vincent, P. and Vink, J. and Vlahakis, N. and Vlahos, L. and Vogler, P. and Vollhardt, A. and Volpe, F. and Von Gunten, H. P. and Vorobiov, S. and Wagner, S. and Wagner, R. M. and Wagner, B. and Wakely, S. P. and Walter, P. and Walter, R. and Warwick, R. and Wawer, P. and Wawrzaszek, R. and Webb, N. and Wegner, P. and Weinstein, A. and Weitzel, Q. and Welsing, R. and Wetteskind, H. and White, R. and Wierzcholska, A. and Wilkinson, M. I. and Williams, D. A. and Winde, M. and Wischnewski, R. and Wisniewski, L. and Wolczko, A. and Wood, M. and Xiong, Q. and Yamamoto, T. and Yamaoka, K. and Yamazaki, R. and Yanagita, S. and Yoffo, B. and Yonetani, M. and Yoshida, A. and Yoshida, T. and Yoshikoshi, T. and Zabalza, V. and Zagdanski, A. and Zajczyk, A. and Zdziarski, A. and Zech, Alraune and Zietara, K. and Ziolkowski, P. and Zitelli, V. and Zychowski, P.},
  title     = {Design concepts for the Cherenkov Telescope Array CTA an advanced facility for ground-based high-energy gamma-ray astronomy},
  series = {Experimental astronomy : an international journal on astronomical instrumentation and data analysis},
  volume    = {32},
  journal   = {Experimental astronomy : an international journal on astronomical instrumentation and data analysis},
  number    = {3},
  publisher = {Springer},
  address   = {Dordrecht},
  organization    = {CTA Consortium},
  issn      = {0922-6435},
  doi       = {10.1007/s10686-011-9247-0},
  pages     = {193 -- 316},
  year      = {2011},
  abstract  = {Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA.},
  language  = {en}
}
@article{StoesselSchultedosSantosetal.2018,
  author    = {Stoessel, Daniel and Schulte, Claudia and dos Santos, Marcia C. Teixeira and Scheller, Dieter and Rebollo-Mesa, Irene and Deuschle, Christian and Walther, Dirk and Schauer, Nicolas and Berg, Daniela and da Costa, Andre Nogueira and Maetzler, Walter},
  title     = {Promising Metabolite Profiles in the Plasma and CSF of Early Clinical},
  series = {Frontiers in Aging Neuroscience},
  volume    = {10},
  journal   = {Frontiers in Aging Neuroscience},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1663-4365},
  doi       = {10.3389/fnagi.2018.00051},
  pages     = {14},
  year      = {2018},
  abstract  = {Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging and rests entirely on clinical features. Thus, there is an urgent need for robust diagnostic biofluid markers. Untargeted metabolomics allows establishing low-molecular compound biomarkers in a wide range of complex diseases by the measurement of various molecular classes in biofluids such as blood plasma, serum, and cerebrospinal fluid (CSF). Here, we applied untargeted high-resolution mass spectrometry to determine plasma and CSF metabolite profiles. We semiquantitatively determined small-molecule levels (<= 1.5 kDa) in the plasma and CSF from early PD patients (disease duration 0-4 years; n = 80 and 40, respectively), and sex-and age-matched controls (n = 76 and 38, respectively). We performed statistical analyses utilizing partial least square and random forest analysis with a 70/30 training and testing split approach, leading to the identification of 20 promising plasma and 14 CSF metabolites. The semetabolites differentiated the test set with an AUC of 0.8 (plasma) and 0.9 (CSF). Characteristics of the metabolites indicate perturbations in the glycerophospholipid, sphingolipid, and amino acid metabolism in PD, which underscores the high power of metabolomic approaches. Further studies will enable to develop a potential metabolite-based biomarker panel specific for PD},
  language  = {en}
}
@article{BardenRixSomervilleetal.2005,
  author    = {Barden, Marco and Rix, Hans-Walter and Somerville, Rachel S. and Bell, Eric F. and H{\"a}ußler, Boris and Peng, Chen Y. and Borch, Andrea and Beckwith, Steven V. W. and Caldwell, John A. R. and Heymans, Catherine and Jahnke, Knud and Jogee, Shardha and McIntosh, Daniel H. and Meisenheimer, Klaus and Sanchez, Sebastian F. and Wisotzki, Lutz and Wolf, C.},
  title     = {GEMS : the surface brightness and surface mass density evolution of disk galaxies},
  year      = {2005},
  abstract  = {We combine HST imaging from the GEMS ( Galaxy Evolution from Morphologies and SEDs) survey with photometric redshifts from COMBO-17 to explore the evolution of disk-dominated galaxies since z less than or similar to 1.1. The sample is composed of all GEMS galaxies with Sersic indices n < 2.5, derived from fits to the galaxy images. We account fully for selection effects through careful analysis of image simulations; we are limited by the depth of the redshift and HST data to the study of galaxies with M-V less than or similar to -20, or equivalently, log (M/M-circle dot) greater than or similar to 10. We find strong evolution in the magnitude-size scaling relation for galaxies with M-V less than or similar to -20, corresponding to a brightening of similar to 1 mag arcsec(-2) in rest-frame V band by z similar to 1. Yet disks at a given absolute magnitude are bluer and have lower stellar mass-to-light ratios at z similar to 1 than at the present day. As a result, our findings indicate weak or no evolution in the relation between stellar mass and effective disk size for galaxies with log (M/M-circle dot) greater than or similar to 10 over the same time interval. This is strongly inconsistent with the most naive theoretical expectation, in which disk size scales in proportion to the halo virial radius, which would predict that disks are a factor of 2 denser at fixed mass at z similar to 1. The lack of evolution in the stellar mass-size relation is consistent with an "inside-out'' growth of galaxy disks on average (galaxies increasing in size as they grow more massive), although we cannot rule out more complex evolutionary scenarios},
  language  = {en}
}
@article{BeerenwinkelSingLengaueretal.2005,
  author    = {Beerenwinkel, Niko and Sing, Tobias and Lengauer, Thomas and Rahnenfuhrer, Joerg and Roomp, Kirsten and Savenkov, Igor and Fischer, Roman and Hoffmann, Daniel and Selbig, Joachim and Korn, Klaus and Walter, Hauke and Berg, Thomas and Braun, Patrick and Faetkenheuer, Gerd and Oette, Mark and Rockstroh, Juergen and Kupfer, Bernd and Kaiser, Rolf and Daeumer, Martin},
  title     = {Computational methods for the design of effective therapies against drug resistant HIV strains},
  year      = {2005},
  abstract  = {The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data},
  language  = {en}
}
@article{JahnkeSanchezWisotzkietal.2004,
  author    = {Jahnke, Knud and Sanchez, Sebastian F. and Wisotzki, Lutz and Barden, Marco and Beckwith, Steven V. W. and Bell, Eric F. and Borch, Andrea and Caldwell, John A. R. and H{\"a}ußler, Boris and Heymans, Catherine and Jogee, Shardha and McIntosh, Daniel H. and Meisenheimer, Klaus and Peng, Chen Y. and Rix, Hans-Walter and Somerville, Rachel S. and Wolf, C.},
  title     = {Ultraviolet light from young stars in GEMS quasar host galaxies at 1.8 < z < 2.75},
  issn      = {0004-637X},
  year      = {2004},
  abstract  = {We have performed Hubble Space Telescope imaging of a sample of 23 high-redshift (1.8<z<2.75) active galactic nuclei (AGNs), drawn from the COMBO-17 survey. The sample contains moderately luminous quasars (M(B)similar to-23). The data are part of the Galaxy Evolution from Morphologies and SEDs imaging survey that provides high-resolution optical images obtained with the Advanced Camera for Surveys in two bands (F606W and F850LP), sampling the rest-frame UV flux of the targets. To deblend the AGN images into nuclear and resolved (host galaxy) components, we use a point-spread function subtraction technique that is strictly conservative with respect to the flux of the host galaxy. We resolve the host galaxies in both filter bands in nine of the 23 AGNs, whereas the remaining 14 objects are considered nondetections, with upper limits of less than 5\% of the nuclear flux. However, when we co-add the unresolved AGN images into a single high signal-to-noise ratio composite image, we find again an unambiguously resolved host galaxy. The recovered host galaxies have apparent magnitudes of 23.0<F606W<26.0 and 22.5<F850LP<24.5, with rest-frame UV colors in the range -0.2<(F606W-F850LP)(obs)<2.3. The rest-frame absolute magnitudes at 200 nm are -20.0<M-200 nm<-22.2. The photometric properties of the composite host are consistent with the individual resolved host galaxies. We find that the UV colors of all host galaxies are substantially bluer than expected from an old population of stars with formation redshift z<=5, independent of the assumed metallicities. These UV colors and luminosities range up to the values found for Lyman break galaxies (LBGs) at z=3. Our results suggest either a recent starburst of, e. g., a few percent of the total stellar mass at 100 Myr before observation, with mass fraction and age strongly degenerate, or the possibility that the detected UV emission may be due to young stars forming continuously. For the latter case we estimate star formation rates of typically \&SIM;6 M\&ODOT; yr(-1) (uncorrected for internal dust attenuation), which again lies in the range of rates implied from the UV flux of LBGs. Our results agree with the recent discovery of enhanced blue stellar light in AGN hosts at lower redshifts},
  language  = {en}
}
@article{SanchezJahnkeWisotzkietal.2004,
  author    = {Sanchez, Sebastian F. and Jahnke, Knud and Wisotzki, Lutz and McIntosh, Daniel H. and Bell, Eric F. and Barden, Marko and Beckwith, Steven V. W. and Borch, Andrea and Caldwell, John A. R. and Haussler, Boris and Jogee, Shardha and Meisenheimer, Klaus and Peng, Chen Y. and Rix, Hans-Walter and Somerville, Rachel S. and Wolf, C.},
  title     = {Colors of active galactic nucleus host galaxies at 0.5 < z < 1.1 from the GEMS survey},
  issn      = {0004-637X},
  year      = {2004},
  abstract  = {We present the results from a study of the host galaxies of 15 optically selected active galactic nuclei (AGNs) with 0.5<z<1.1 from the Galaxy Evolution from Morphology and SEDs project (GEMS). GEMS is a Hubble Space Telescope imaging survey of a similar to28' x 28' contiguous field centered on the Chandra Deep Field-South in the F606W and F850LP filter bands. It incorporates the spectral energy distributions and redshifts of similar to10,000 objects, obtained by the COMBO-17 project. We have detected the host galaxies of all 15 AGNs in the F850LP band (and 13 of 15 in the F606W band), recovering their fluxes, morphologies, and structural parameters. We find that 80\% of the host galaxies have early-type (bulge-dominated) morphologies, while the rest have structures characteristic of late-type (disk-dominated) galaxies. We find that 25\% of the early types and 30\% of the late types exhibit disturbances consistent with galaxy interactions. The hosts show a wide range of colors, from those of red-sequence galaxies to blue colors consistent with ongoing star formation. Roughly 70\% of the morphologically early-type hosts have rest-frame blue colors, a much larger fraction than those typical of nonactive morphologically early-type galaxies in this redshift and luminosity range. Yet, we find that the early-type hosts are structurally similar to red-sequence elliptical galaxies, inasmuch as they follow an absolute magnitude versus half-light size correlation that is consistent with the mean relation for early-type galaxies at similar redshifts},
  language  = {en}
}
@article{StoesselStellmannWillingetal.2018,
  author    = {Stoessel, Daniel and Stellmann, Jan-Patrick and Willing, Anne and Behrens, Birte and Rosenkranz, Sina C. and Hodecker, Sibylle C. and Stuerner, Klarissa H. and Reinhardt, Stefanie and Fleischer, Sabine and Deuschle, Christian and Maetzler, Walter and Berg, Daniela and Heesen, Christoph and Walther, Dirk and Schauer, Nicolas and Friese, Manuel A. and Pless, Ole},
  title     = {Metabolomic Profiles for Primary Progressive Multiple Sclerosis Stratification and Disease Course Monitoring},
  series = {Frontiers in human neuroscienc},
  volume    = {12},
  journal   = {Frontiers in human neuroscienc},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1662-5161},
  doi       = {10.3389/fnhum.2018.00226},
  pages     = {13},
  year      = {2018},
  abstract  = {Primary progressive multiple sclerosis (PPMS) shows a highly variable disease progression with poor prognosis and a characteristic accumulation of disabilities in patients. These hallmarks of PPMS make it difficult to diagnose and currently impossible to efficiently treat. This study aimed to identify plasma metabolite profiles that allow diagnosis of PPMS and its differentiation from the relapsing remitting subtype (RRMS), primary neurodegenerative disease (Parkinson's disease, PD), and healthy controls (HCs) and that significantly change during the disease course and could serve as surrogate markers of multiple sclerosis (MS)-associated neurodegeneration over time. We applied untargeted high-resolution metabolomics to plasma samples to identify PPMS-specific signatures, validated our findings in independent sex- and age-matched PPMS and HC cohorts and built discriminatory models by partial least square discriminant analysis (PLS-DA). This signature was compared to sex- and age-matched RRMS patients, to patients with PD and HC. Finally, we investigated these metabolites in a longitudinal cohort of PPMS patients over a 24-month period. PLS-DA yielded predictive models for classification along with a set of 20 PPMS-specific informative metabolite markers. These metabolites suggest disease-specific alterations in glycerophospholipid and linoleic acid pathways. Notably, the glycerophospholipid LysoPC(20:0) significantly decreased during the observation period. These findings show potential for diagnosis and disease course monitoring, and might serve as biomarkers to assess treatment efficacy in future clinical trials for neuroprotective MS therapies.},
  language  = {en}
}
@article{MemczakLausterKaretal.2016,
  author    = {Memczak, Henry and Lauster, Daniel and Kar, Parimal and Di Lella, Santiago and Volkmer, Rudolf and Knecht, Volker and Herrmann, Andreas and Ehrentreich-Foerster, Eva and Bier, Frank Fabian and Stoecklein, Walter F. M.},
  title     = {Anti-Hemagglutinin Antibody Derived Lead Peptides for Inhibitors of Influenza Virus Binding},
  series = {PLoS one},
  volume    = {11},
  journal   = {PLoS one},
  publisher = {PLoS},
  address   = {San Fransisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0159074},
  pages     = {82 -- 90},
  year      = {2016},
  abstract  = {Antibodies against spike proteins of influenza are used as a tool for characterization of viruses and therapeutic approaches. However, development, production and quality control of antibodies is expensive and time consuming. To circumvent these difficulties, three peptides were derived from complementarity determining regions of an antibody heavy chain against influenza A spike glycoprotein. Their binding properties were studied experimentally, and by molecular dynamics simulations. Two peptide candidates showed binding to influenza A/Aichi/2/68 H3N2. One of them, termed PeB, with the highest affinity prevented binding to and infection of target cells in the micromolar region without any cytotoxic effect. PeB matches best the conserved receptor binding site of hemagglutinin. PeB bound also to other medical relevant influenza strains, such as human-pathogenic A/California/7/2009 H1N1, and avian-pathogenic A/MuteSwan/Rostock/R901/2006 H7N1. Strategies to improve the affinity and to adapt specificity are discussed and exemplified by a double amino acid substituted peptide, obtained by substitutional analysis. The peptides and their derivatives are of great potential for drug development as well as biosensing.},
  language  = {en}
}
@misc{MemczakLausterKaretal.2016,
  author    = {Memczak, Henry and Lauster, Daniel and Kar, Parimal and Di Lella, Santiago and Volkmer, Rudolf and Knecht, Volker and Herrmann, Andreas and Ehrentreich-F{\"o}rster, Eva and Bier, Frank Fabian and St{\"o}cklein, Walter F. M.},
  title     = {Anti-hemagglutinin antibody derived lead peptides for inhibitors of influenza virus binding},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe},
  number    = {536},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-41087},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-410872},
  pages     = {24},
  year      = {2016},
  abstract  = {Antibodies against spike proteins of influenza are used as a tool for characterization of viruses and therapeutic approaches. However, development, production and quality control of antibodies is expensive and time consuming. To circumvent these difficulties, three peptides were derived from complementarity determining regions of an antibody heavy chain against influenza A spike glycoprotein. Their binding properties were studied experimentally, and by molecular dynamics simulations. Two peptide candidates showed binding to influenza A/Aichi/2/68 H3N2. One of them, termed PeB, with the highest affinity prevented binding to and infection of target cells in the micromolar region without any cytotoxic effect. PeB matches best the conserved receptor binding site of hemagglutinin. PeB bound also to other medical relevant influenza strains, such as human-pathogenic A/California/7/2009 H1N1, and avian-pathogenic A/MuteSwan/Rostock/R901/2006 H7N1. Strategies to improve the affinity and to adapt specificity are discussed and exemplified by a double amino acid substituted peptide, obtained by substitutional analysis. The peptides and their derivatives are of great potential for drug development as well as biosensing.},
  language  = {en}
}
@inproceedings{MemczakLausterHerrmannetal.2013,
  author    = {Memczak, Henry and Lauster, Daniel and Herrmann, Andreas and St{\"o}cklein, Walter F. M. and Bier, Frank Fabian},
  title     = {Novel hemagglutinin-binding peptides for biosensing and inhibition of Influenza Viruses},
  series = {Biopolymers},
  volume    = {100},
  booktitle = {Biopolymers},
  number    = {3},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {0006-3525},
  pages     = {255 -- 255},
  year      = {2013},
  language  = {en}
}
@book{IhleGroenWalteretal.2012,
  author    = {Ihle, Wolfgang and Groen, Gunter and Walter, Daniel and Esser, G{\"u}nter and Petermann, Franz},
  title     = {Depression},
  series = {Leitfaden Kinder- und Jugendpsychotherapie},
  volume    = {16},
  journal   = {Leitfaden Kinder- und Jugendpsychotherapie},
  publisher = {Hogrefe},
  address   = {G{\"o}ttingen},
  isbn      = {978-3-8017-2381-1},
  pages     = {IX, 162 S.},
  year      = {2012},
  language  = {de}
}
@article{MartinezGarciaRosellMeleJaccardetal.2011,
  author    = {Martinez-Garcia, Alfredo and Rosell-Mele, Antoni and Jaccard, Samuel L. and Geibert, Walter and Sigman, Daniel M. and Haug, Gerald H.},
  title     = {Southern Ocean dust-climate coupling over the past four million years},
  series = {Nature : the international weekly journal of science},
  volume    = {476},
  journal   = {Nature : the international weekly journal of science},
  number    = {7360},
  publisher = {Nature Publ. Group},
  address   = {London},
  issn      = {0028-0836},
  doi       = {10.1038/nature10310},
  pages     = {312 -- U141},
  year      = {2011},
  abstract  = {Dust has the potential to modify global climate by influencing the radiative balance of the atmosphere and by supplying iron and other essential limiting micronutrients to the ocean(1,2). Indeed, dust supply to the Southern Ocean increases during ice ages, and 'iron fertilization' of the subantarctic zone may have contributed up to 40 parts per million by volume (p. p. m. v.) of the decrease (80-100 p. p. m. v.) in atmospheric carbon dioxide observed during late Pleistocene glacial cycles(3-7). So far, however, the magnitude of Southern Ocean dust deposition in earlier times and its role in the development and evolution of Pleistocene glacial cycles have remained unclear. Here we report a high-resolution record of dust and iron supply to the Southern Ocean over the past four million years, derived from the analysis of marine sediments from ODP Site 1090, located in the Atlantic sector of the subantarctic zone. The close correspondence of our dust and iron deposition records with Antarctic ice core reconstructions of dust flux covering the past 800,000 years (refs 8, 9) indicates that both of these archives record large-scale deposition changes that should apply to most of the Southern Ocean, validating previous interpretations of the ice core data. The extension of the record beyond the interval covered by the Antarctic ice cores reveals that, in contrast to the relatively gradual intensification of glacial cycles over the past three million years, Southern Ocean dust and iron flux rose sharply at the Mid-Pleistocene climatic transition around 1.25 million years ago. This finding complements previous observations over late Pleistocene glacial cycles(5,8,9), providing new evidence of a tight connection between high dust input to the Southern Ocean and the emergence of the deep glaciations that characterize the past one million years of Earth history.},
  language  = {en}
}
@misc{StoesselStellmannWillingetal.2018,
  author    = {Stoessel, Daniel and Stellmann, Jan-Patrick and Willing, Anne and Behrens, Birte and Rosenkranz, Sina C. and Hodecker, Sibylle C. and St{\"u}rner, Klarissa H. and Reinhardt, Stefanie and Fleischer, Sabine and Deuschle, Christian and Maetzler, Walter and Berg, Daniela and Heesen, Christoph and Walther, Dirk and Schauer, Nicolas and Friese, Manuel A. and Pless, Ole},
  title     = {Metabolomic profiles for primary progressive multiple sclerosis stratification and disease course monitoring},
  series = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam Mathematisch-Naturwissenschaftliche Reihe},
  number    = {694},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-42630},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-426307},
  pages     = {13},
  year      = {2018},
  abstract  = {Primary progressive multiple sclerosis (PPMS) shows a highly variable disease progression with poor prognosis and a characteristic accumulation of disabilities in patients. These hallmarks of PPMS make it difficult to diagnose and currently impossible to efficiently treat. This study aimed to identify plasma metabolite profiles that allow diagnosis of PPMS and its differentiation from the relapsing remitting subtype (RRMS), primary neurodegenerative disease (Parkinson's disease, PD), and healthy controls (HCs) and that significantly change during the disease course and could serve as surrogate markers of multiple sclerosis (MS)-associated neurodegeneration over time. We applied untargeted high-resolution metabolomics to plasma samples to identify PPMS-specific signatures, validated our findings in independent sex- and age-matched PPMS and HC cohorts and built discriminatory models by partial least square discriminant analysis (PLS-DA). This signature was compared to sex- and age-matched RRMS patients, to patients with PD and HC. Finally, we investigated these metabolites in a longitudinal cohort of PPMS patients over a 24-month period. PLS-DA yielded predictive models for classification along with a set of 20 PPMS-specific informative metabolite markers. These metabolites suggest disease-specific alterations in glycerophospholipid and linoleic acid pathways. Notably, the glycerophospholipid LysoPC(20:0) significantly decreased during the observation period. These findings show potential for diagnosis and disease course monitoring, and might serve as biomarkers to assess treatment efficacy in future clinical trials for neuroprotective MS therapies.},
  language  = {en}
}
@misc{ThulinKrahMeyeretal.2018,
  author    = {Thulin, Mirjam and Krah, Markus and Meyer, Michael A. and Schorsch, Ismar and Brodt, Eliezer and Sariel, Eliezer and Yedidya, Asaf and Esther, Solomon and Kessler, Samuel J. and Bratkin, Dimitri and Sax, Benjamin E. and Stair, Rose and Ariel, Yaakov S. and Weidner, Daniel and Ebert, Sophia and Martini, Annett and Fischer, Bernd and Th{\"u}ne, Eva-Maria and Bock, Dennis and Engelmann, Jonas and Aust, Cornelia and Walter, Nancy},
  title     = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien = Cultures of Wissenschaft des Judentums at 200},
  series = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e. V.},
  journal   = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e. V.},
  number    = {24},
  editor    = {Krah, Markus and Thulin, Mirjam and Pick, Bianca},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-440-1},
  issn      = {1614-6492},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-414943},
  pages     = {280},
  year      = {2018},
  abstract  = {PaRDeS, the journal of the German Association for Jewish Studies, aims at exploring the fruitful and multifarious cultures of Judaism as well as their relations to their environment within diverse areas of research. In addition, the journal promotes Jewish Studies within academic discourse and reflects on its historic and social responsibilities.},
  language  = {en}
}
@article{HehnMendezUebernickeletal.2019,
  author    = {Hehn, Jennifer and Mendez, Daniel and Uebernickel, Falk and Brenner, Walter and Broy, Manfred},
  title     = {On integrating design thinking for human-centered requirements engineering},
  series = {IEEE software},
  volume    = {37},
  journal   = {IEEE software},
  number    = {2},
  publisher = {Inst. of Electr. and Electronics Engineers},
  address   = {Los Alamitos},
  issn      = {0740-7459},
  doi       = {10.1109/MS.2019.2957715},
  pages     = {25 -- 31},
  year      = {2019},
  abstract  = {We elaborate on the possibilities and needs to integrate design thinking into requirements engineering, drawing from our research and project experiences. We suggest three approaches for tailoring and integrating design thinking and requirements engineering with complementary synergies and point at open challenges for research and practice.},
  language  = {en}
}
@article{AceroAloisioAmansetal.2017,
  author    = {Acero, F. and Aloisio, R. and Amans, J. and Amato, Elena and Antonelli, L. A. and Aramo, C. and Armstrong, T. and Arqueros, F. and Asano, Katsuaki and Ashley, M. and Backes, M. and Balazs, C. and Balzer, A. and Bamba, Aya and Barkov, Maxim and Barrio, J. A. and Benbow, Wystan and Bernloehr, K. and Beshley, V. and Bigongiari, C. and Biland, A. and Bilinsky, A. and Bissaldi, Elisabetta and Biteau, J. and Blanch, O. and Blasi, P. and Blazek, J. and Boisson, C. and Bonanno, G. and Bonardi, A. and Bonavolonta, C. and Bonnoli, G. and Braiding, C. and Brau-Nogue, S. and Bregeon, J. and Brown, A. M. and Bugaev, V. and Bulgarelli, A. and Bulik, T. and Burton, Michael and Burtovoi, A. and Busetto, G. and Bottcher, M. and Cameron, R. and Capalbi, M. and Caproni, Anderson and Caraveo, P. and Carosi, R. and Cascone, E. and Cerruti, M. and Chaty, Sylvain and Chen, A. and Chen, X. and Chernyakova, M. and Chikawa, M. and Chudoba, J. and Cohen-Tanugi, J. and Colafrancesco, S. and Conforti, V. and Contreras, J. L. and Costa, A. and Cotter, G. and Covino, Stefano and Covone, G. and Cumani, P. and Cusumano, G. and Daniel, M. and Dazzi, F. and De Angelis, A. and De Cesare, G. and De Franco, A. and De Frondat, F. and Dal Pino, E. M. de Gouveia and De Lisio, C. and Lopez, R. de los Reyes and De Lotto, B. and de Naurois, M. and De Palma, F. and Del Santo, M. and Delgado, C. and della Volpe, D. and Di Girolamo, T. and Di Giulio, C. and Di Pierro, F. and Di Venere, L. and Doro, M. and Dournaux, J. and Dumas, D. and Dwarkadas, Vikram V. and Diaz, C. and Ebr, J. and Egberts, Kathrin and Einecke, S. and Elsaesser, D. and Eschbach, S. and Falceta-Goncalves, D. and Fasola, G. and Fedorova, E. and Fernandez-Barral, A. and Ferrand, Gilles and Fesquet, M. and Fiandrini, E. and Fiasson, A. and Filipovic, Miroslav D. and Fioretti, V. and Font, L. and Fontaine, Gilles and Franco, F. J. and Freixas Coromina, L. and Fujita, Yutaka and Fukui, Y. and Funk, S. and Forster, A. and Gadola, A. and Lopez, R. Garcia and Garczarczyk, M. and Giglietto, N. and Giordano, F. and Giuliani, A. and Glicenstein, J. and Gnatyk, R. and Goldoni, P. and Grabarczyk, T. and Graciani, R. and Graham, J. and Grandi, P. and Granot, Jonathan and Green, A. J. and Griffiths, S. and Gunji, S. and Hakobyan, H. and Hara, S. and Hassan, T. and Hayashida, M. and Heller, M. and Helo, J. C. and Hinton, J. and Hnatyk, B. and Huet, J. and Huetten, M. and Humensky, T. B. and Hussein, M. and Horandel, J. and Ikeno, Y. and Inada, T. and Inome, Y. and Inoue, S. and Inoue, T. and Inoue, Y. and Ioka, K. and Iori, Maurizio and Jacquemier, J. and Janecek, P. and Jankowsky, D. and Jung, I. and Kaaret, P. and Katagiri, H. and Kimeswenger, S. and Kimura, Shigeo S. and Knodlseder, J. and Koch, B. and Kocot, J. and Kohri, K. and Komin, N. and Konno, Y. and Kosack, K. and Koyama, S. and Kraus, Michaela and Kubo, Hidetoshi and Mezek, G. Kukec and Kushida, J. and La Palombara, N. and Lalik, K. and Lamanna, G. and Landt, H. and Lapington, J. and Laporte, P. and Lee, S. and Lees, J. and Lefaucheur, J. and Lenain, J. -P. and Leto, Giuseppe and Lindfors, E. and Lohse, T. and Lombardi, S. and Longo, F. and Lopez, M. and Lucarelli, F. and Luque-Escamilla, Pedro Luis and Lopez-Coto, R. and Maccarone, M. C. and Maier, G. and Malaguti, G. and Mandat, D. and Maneva, G. and Mangano, S. and Marcowith, Alexandre and Marti, J. and Martinez, M. and Martinez, G. and Masuda, S. and Maurin, G. and Maxted, N. and Melioli, Claudio and Mineo, T. and Mirabal, N. and Mizuno, T. and Moderski, R. and Mohammed, M. and Montaruli, T. and Moralejo, A. and Mori, K. and Morlino, G. and Morselli, A. and Moulin, Emmanuel and Mukherjee, R. and Mundell, C. and Muraishi, H. and Murase, Kohta and Nagataki, Shigehiro and Nagayoshi, T. and Naito, T. and Nakajima, D. and Nakamori, T. and Nemmen, R. and Niemiec, Jacek and Nieto, D. and Nievas-Rosillo, M. and Nikolajuk, M. and Nishijima, K. and Noda, K. and Nogues, L. and Nosek, D. and Novosyadlyj, B. and Nozaki, S. and Ohira, Yutaka and Ohishi, M. and Ohm, S. and Okumura, A. and Ong, R. A. and Orito, R. and Orlati, A. and Ostrowski, M. and Oya, I. and Padovani, Marco and Palacio, J. and Palatka, M. and Paredes, Josep M. and Pavy, S. and Persic, M. and Petrucci, P. and Petruk, Oleh and Pisarski, A. and Pohl, Martin and Porcelli, A. and Prandini, E. and Prast, J. and Principe, G. and Prouza, M. and Pueschel, Elisa and Puelhofer, G. and Quirrenbach, A. and Rameez, M. and Reimer, O. and Renaud, M. and Ribo, M. and Rico, J. and Rizi, V. and Rodriguez, J. and Fernandez, G. Rodriguez and Rodriguez Vazquez, J. J. and Romano, Patrizia and Romeo, G. and Rosado, J. and Rousselle, J. and Rowell, G. and Rudak, B. and Sadeh, I. and Safi-Harb, S. and Saito, T. and Sakaki, N. and Sanchez, D. and Sangiorgi, P. and Sano, H. and Santander, M. and Sarkar, S. and Sawada, M. and Schioppa, E. J. and Schoorlemmer, H. and Schovanek, P. and Schussler, F. and Sergijenko, O. and Servillat, M. and Shalchi, A. and Shellard, R. C. and Siejkowski, H. and Sillanpaa, A. and Simone, D. and Sliusar, V. and Sol, H. and Stanic, S. and Starling, R. and Stawarz, L. and Stefanik, S. and Stephan, M. and Stolarczyk, T. and Szanecki, M. and Szepieniec, T. and Tagliaferri, G. and Tajima, H. and Takahashi, M. and Takeda, J. and Tanaka, M. and Tanaka, S. and Tejedor, L. A. and Telezhinsky, Igor O. and Temnikov, P. and Terada, Y. and Tescaro, D. and Teshima, M. and Testa, V. and Thoudam, S. and Tokanai, F. and Torres, D. F. and Torresi, E. and Tosti, G. and Townsley, C. and Travnicek, P. and Trichard, C. and Trifoglio, M. and Tsujimoto, S. and Vagelli, V. and Vallania, P. and Valore, L. and van Driel, W. and van Eldik, C. and Vandenbroucke, Justin and Vassiliev, V. and Vecchi, M. and Vercellone, Stefano and Vergani, S. and Vigorito, C. and Vorobiov, S. and Vrastil, M. and Vazquez Acosta, M. L. and Wagner, S. J. and Wagner, R. and Wakely, S. P. and Walter, R. and Ward, J. E. and Watson, J. J. and Weinstein, A. and White, M. and White, R. and Wierzcholska, A. and Wilcox, P. and Williams, D. A. and Wischnewski, R. and Wojcik, P. and Yamamoto, T. and Yamamoto, H. and Yamazaki, Ryo and Yanagita, S. and Yang, L. and Yoshida, T. and Yoshida, M. and Yoshiike, S. and Yoshikoshi, T. and Zacharias, M. and Zampieri, L. and Zanin, R. and Zavrtanik, M. and Zavrtanik, D. and Zdziarski, A. and Zech, Alraune and Zechlin, Hannes and Zhdanov, V. and Ziegler, A. and Zorn, J.},
  title     = {Prospects for Cherenkov Telescope Array Observations of the Young Supernova Remnant RX J1713.7-3946},
  series = {The astrophysical journal : an international review of spectroscopy and astronomical physics},
  volume    = {840},
  journal   = {The astrophysical journal : an international review of spectroscopy and astronomical physics},
  number    = {2},
  publisher = {IOP Publ. Ltd.},
  address   = {Bristol},
  issn      = {0004-637X},
  doi       = {10.3847/1538-4357/aa6d67},
  pages     = {14},
  year      = {2017},
  abstract  = {We perform simulations for future Cherenkov Telescope Array (CTA) observations of RX J1713.7-3946, a young supernova remnant (SNR) and one of the brightest sources ever discovered in very high energy (VHE) gamma rays. Special attention is paid to exploring possible spatial (anti) correlations of gamma rays with emission at other wavelengths, in particular X-rays and CO/H I emission. We present a series of simulated images of RX J1713.7-3946 for CTA based on a set of observationally motivated models for the gamma-ray emission. In these models, VHE gamma rays produced by high-energy electrons are assumed to trace the nonthermal X-ray emission observed by XMM-Newton, whereas those originating from relativistic protons delineate the local gas distributions. The local atomic and molecular gas distributions are deduced by the NANTEN team from CO and H I observations. Our primary goal is to show how one can distinguish the emission mechanism(s) of the gamma rays (i.e., hadronic versus leptonic, or a mixture of the two) through information provided by their spatial distribution, spectra, and time variation. This work is the first attempt to quantitatively evaluate the capabilities of CTA to achieve various proposed scientific goals by observing this important cosmic particle accelerator.},
  language  = {en}
}
@article{AhnenAnsoldiAntonellietal.2018,
  author    = {Ahnen, M. L. and Ansoldi, S. and Antonelli, L. A. and Arcaro, C. and Babic, A. and Banerjee, B. and Bangale, P. and Barres de Almeida, U. and Barrio, J. A. and Gonzalez, J. Becerra and Bednarek, W. and Bernardini, E. and Berti, A. and Bhattacharyya, W. and Blanch, O. and Bonnoli, G. and Carosi, R. and Carosi, A. and Chatterjee, A. and Colak, S. M. and Colin, P. and Colombo, E. and Contreras, J. L. and Cortina, J. and Covino, S. and Cumani, P. and Da Vela, P. and Dazzi, F. and De Angelis, A. and De Lotto, B. and Delfino, M. and Delgado, Jose Miguel Martins and Di Pierro, F. and Doert, M. and Dominguez, A. and Prester, D. Dominis and Doro, M. and Glawion, D. Eisenacher and Engelkemeier, M. and Ramazani, V. Fallah and Fernandez-Barral, A. and Fidalgo, D. and Fonseca, M. V. and Font, L. and Fruck, C. and Galindo, D. and Lopez, R. J. Garcia and Garczarczyk, M. and Gaug, M. and Giammaria, P. and Godinovic, N. and Gora, D. and Guberman, D. and Hadasch, D. and Hahn, A. and Hassan, T. and Hayashida, M. and Herrera, J. and Hose, J. and Hrupec, D. and Ishio, K. and Konno, Y. and Kubo, H. and Kushida, J. and Kuvezdic, D. and Lelas, D. and Lindfors, E. and Lombardi, S. and Longo, F. and Lopez, M. and Maggio, C. and Majumdar, P. and Makariev, M. and Maneva, G. and Manganaro, M. and Maraschi, L. and Mariotti, M. and Martinez, M. and Mazin, D. and Menzel, U. and Minev, M. and Miranda, J. M. and Mirzoyan, R. and Moralejo, A. and Moreno, V. and Moretti, E. and Nagayoshi, T. and Neustroev, V. and Niedzwiecki, A. and Nievas Rosillo, M. and Nigro, C. and Nilsson, K. and Ninci, D. and Nishijima, K. and Noda, K. and Nogues, L. and Paiano, S. and Palacio, J. and Paneque, D. and Paoletti, R. and Paredes, J. M. and Pedaletti, G. and Peresano, M. and Perri, L. and Persic, M. and Moroni, P. G. Prada and Prandini, E. and Puljak, I. and Garcia, J. R. and Reichardt, I. and Ribo, M. and Rico, J. and Righi, C. and Rugliancich, A. and Saito, T. and Satalecka, K. and Schroeder, S. and Schweizer, T. and Shore, S. N. and Sitarek, J. and Snidaric, I. and Sobczynska, D. and Stamerra, A. and Strzys, M. and Suric, T. and Takalo, L. and Tavecchio, F. and Temnikov, P. and Terzic, T. and Teshima, M. and Torres-Alba, N. and Treves, A. and Tsujimoto, S. and Vanzo, G. and Vazquez Acosta, M. and Vovk, I. and Ward, J. E. and Will, M. and Zaric, D. and Arbet-Engels, A. and Baack, D. and Balbo, M. and Biland, A. and Blank, M. and Bretz, T. and Bruegge, K. and Bulinski, M. and Buss, J. and Dmytriiev, A. and Dorner, D. and Einecke, S. and Elsaesser, D. and Herbst, T. and Hildebrand, D. and Kortmann, L. and Linhoff, L. and Mahlke, M. and Mannheim, K. and Mueller, S. A. and Neise, D. and Neronov, A. and Noethe, M. and Oberkirch, J. and Paravac, A. and Rhode, W. and Schleicher, B. and Schulz, F. and Sedlaczek, K. and Shukla, A. and Sliusar, V. and Walter, R. and Archer, A. and Benbow, W. and Bird, R. and Brose, Robert and Buckley, J. H. and Bugaev, V. and Christiansen, J. L. and Cui, W. and Daniel, M. K. and Falcone, A. and Feng, Q. and Finley, J. P. and Gillanders, G. H. and Gueta, O. and Hanna, D. and Hervet, O. and Holder, J. and Hughes, G. and Huetten, M. and Humensky, T. B. and Johnson, C. A. and Kaaret, P. and Kar, P. and Kelley-Hoskins, N. and Kertzman, M. and Kieda, D. and Krause, M. and Krennrich, F. and Kumar, S. and Lang, M. J. and Lin, T. T. Y. and Maier, G. and McArthur, S. and Moriarty, P. and Mukherjee, R. and Ong, R. A. and Otte, A. N. and Park, N. and Petrashyk, A. and Pichel, A. and Pohl, Martin and Quinn, J. and Ragan, K. and Reynolds, P. T. and Richards, G. T. and Roache, E. and Rovero, A. C. and Rulten, C. and Sadeh, I. and Santander, M. and Sembroski, G. H. and Shahinyan, K. and Sushch, Iurii and Tyler, J. and Wakely, S. P. and Weinstein, A. and Wells, R. M. and Wilcox, P. and Wilhel, A. and Williams, D. A. and Williamson, T. J. and Zitzer, B. and Perri, M. and Verrecchia, F. and Leto, C. and Villata, M. and Raiteri, C. M. and Jorstad, S. G. and Larionov, V. M. and Blinov, D. A. and Grishina, T. S. and Kopatskaya, E. N. and Larionova, E. G. and Nikiforova, A. A. and Morozova, D. A. and Troitskaya, Yu. V. and Troitsky, I. S. and Kurtanidze, O. M. and Nikolashvili, M. G. and Kurtanidze, S. O. and Kimeridze, G. N. and Chigladze, R. A. and Strigachev, A. and Sadun, A. C.},
  title     = {Extreme HBL behavior of Markarian 501 during 2012},
  series = {Astronomy and astrophysics : an international weekly journal / European Southern Observatory (ESO)},
  volume    = {620},
  journal   = {Astronomy and astrophysics : an international weekly journal / European Southern Observatory (ESO)},
  publisher = {EDP Sciences},
  address   = {Les Ulis},
  organization    = {MAGIC Collaboration FACT Collaboration VERITAS Collaboration},
  issn      = {1432-0746},
  doi       = {10.1051/0004-6361/201833704},
  pages     = {23},
  year      = {2018},
  abstract  = {Aims. We aim to characterize the multiwavelength emission from Markarian 501 (Mrk 501), quantify the energy-dependent variability, study the potential multiband correlations, and describe the temporal evolution of the broadband emission within leptonic theoretical scenarios. Methods. We organized a multiwavelength campaign to take place between March and July of 2012. Excellent temporal coverage was obtained with more than 25 instruments, including the MAGIC, FACT and VERITAS Cherenkov telescopes, the instruments on board the Swift and Fermi spacecraft, and the telescopes operated by the GASP-WEBT collaboration. Results. Mrk 501 showed a very high energy (VHE) gamma-ray flux above 0.2 TeV of similar to 0.5 times the Crab Nebula flux (CU) for most of the campaign. The highest activity occurred on 2012 June 9, when the VHE flux was similar to 3 CU, and the peak of the high-energy spectral component was found to be at similar to 2 TeV. Both the X-ray and VHE gamma-ray spectral slopes were measured to be extremely hard, with spectral indices <2 during most of the observing campaign, regardless of the X-ray and VHE flux. This study reports the hardest Mrk 501 VHE spectra measured to date. The fractional variability was found to increase with energy, with the highest variability occurring at VHE. Using the complete data set, we found correlation between the X-ray and VHE bands; however, if the June 9 flare is excluded, the correlation disappears (significance <3 sigma) despite the existence of substantial variability in the X-ray and VHE bands throughout the campaign. Conclusions. The unprecedentedly hard X-ray and VHE spectra measured imply that their low- and high-energy components peaked above 5 keV and 0.5 TeV, respectively, during a large fraction of the observing campaign, and hence that Mrk 501 behaved like an extreme high-frequency-peaked blazar (EHBL) throughout the 2012 observing season. This suggests that being an EHBL may not be a permanent characteristic of a blazar, but rather a state which may change over time. The data set acquired shows that the broadband spectral energy distribution (SED) of Mrk 501, and its transient evolution, is very complex, requiring, within the framework of synchrotron self-Compton (SSC) models, various emission regions for a satisfactory description. Nevertheless the one-zone SSC scenario can successfully describe the segments of the SED where most energy is emitted, with a significant correlation between the electron energy density and the VHE gamma-ray activity, suggesting that most of the variability may be explained by the injection of high-energy electrons. The one-zone SSC scenario used reproduces the behavior seen between the measured X-ray and VHE gamma-ray fluxes, and predicts that the correlation becomes stronger with increasing energy of the X-rays.},
  language  = {en}
}
@article{EiblMuellerWalteretal.2021,
  author    = {Eibl, Eva P. S. and M{\"u}ller, Daniel and Walter, Thomas R. and Allahbakhshi, Masoud and Jousset, Philippe and Hersir, Gylfi P{\´a}ll and Dahm, Torsten},
  title     = {Eruptive cycle and bubble trap of Strokkur Geyser, Iceland},
  series = {Journal of geophysical research : JGR. B: Solid earth},
  volume    = {126},
  journal   = {Journal of geophysical research : JGR. B: Solid earth},
  number    = {4},
  publisher = {Wiley},
  address   = {Hoboken, NJ},
  issn      = {2169-9313},
  doi       = {10.1029/2020JB020769},
  pages     = {20},
  year      = {2021},
  abstract  = {The eruption frequency of geysers can be studied easily on the surface. However, details of the internal structure including possible water and gas filled chambers feeding eruptions and the driving mechanisms often remain elusive. We used a multidisciplinary network of seismometers, video cameras, water pressure sensors and one tiltmeter to study the eruptive cycle, internal structure, and mechanisms driving the eruptive cycle of Strokkur geyser in June 2018. An eruptive cycle at Strokkur always consists of four phases: (1) Eruption, (2) post-eruptive conduit refilling, (3) gas filling of the bubble trap, and (4) regular bubble collapse at shallow depth in the conduit. For a typical single eruption 19 +/- 4 bubble collapses occur in Phase 3 and 8 +/- 2 collapses in Phase 4 at a mean spacing of 1.52 +/- 0.29 and 24.5 +/- 5.9 s, respectively. These collapses release latent heat to the fluid in the bubble trap (Phase 3) and later to the fluid in the conduit (Phase 4). The latter eventually reaches thermodynamic conditions for an eruption. Single to sextuple eruptions have similar spacings between bubble collapses and are likely fed from the same bubble trap at 23.7 +/- 4.4 m depth, 13-23 m west of the conduit. However, the duration of the eruption and recharging phase linearly increases likely due to a larger water, gas and heat loss from the system. Our tremor data provides documented evidence for a bubble trap beneath a pool geyser.},
  language  = {en}
}
@misc{SaritoprakVorpahlTuranetal.2016,
  author    = {Saritoprak, Zeki and Vorpahl, Daniel and Turan, Hakan and Arslan, Hakki and Zoref, Arye and Tarabieh, Abdallah and Yeshaya, Joachim and Anzi, Menashe and Merkur, Lianne and Schmidt, Daniela and Schuster, Dirk and Langer, Armin and Blum, Rahel and St{\"u}rmann, Jakob and Pohlmann, Julia and Schulz, Michael Karl and Arnold, Rafael D. and Salzer, Dorothea M. and Geißler-Gr{\"u}nberg, Anke and Talabardon, Susanne and Rasumny, Wiebke and Stellmacher, Martha and Denz, Rebekka and Walter, Simon and Gr{\"o}zinger, Elvira},
  title     = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien = Muslimisch-J{\"u}discher Dialog},
  series = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e.V.},
  journal   = {PaRDeS : Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e.V.},
  number    = {22},
  editor    = {Riemer, Nathanael and Sanci, Kadir and Schulz, Michael Karl},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-370-1},
  issn      = {1614-6492},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-95416},
  pages     = {280},
  year      = {2016},
  abstract  = {PaRDeS. Zeitschrift der Vereinigung f{\"u}r J{\"u}dische Studien e.V., m{\"o}chte die fruchtbare und facettenreiche Kultur des Judentums sowie seine Ber{\"u}hrungspunkte zur Umwelt in den unterschiedlichen Bereichen dokumentieren. Daneben dient die Zeitschrift als Forum zur Positionierung der F{\"a}cher J{\"u}dische Studien und Judaistik innerhalb des wissenschaftlichen Diskurses sowie zur Diskussion ihrer historischen und gesellschaftlichen Verantwortung.},
  language  = {de}
}
@article{PotenteLeveilleBourretYousefietal.2022,
  author    = {Potente, Giacomo and L{\´e}veill{\´e}-Bourret, {\´E}tienne and Yousefi, Narjes and Choudhury, Rimjhim Roy and Keller, Barbara and Diop, Seydina Issa and Duijsings, Dani{\"e}l and Pirovano, Walter and Lenhard, Michael and Sz{\"o}v{\´e}nyi, P{\´e}ter and Conti, Elena},
  title     = {Comparative genomics elucidates the origin of a supergene controlling floral heteromorphism},
  series = {Molecular biology and evolution : MBE},
  volume    = {39},
  journal   = {Molecular biology and evolution : MBE},
  number    = {2},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {0737-4038},
  doi       = {10.1093/molbev/msac035},
  pages     = {16},
  year      = {2022},
  abstract  = {Supergenes are nonrecombining genomic regions ensuring the coinheritance of multiple, coadapted genes. Despite the importance of supergenes in adaptation, little is known on how they originate. A classic example of supergene is the S locus controlling heterostyly, a floral heteromorphism occurring in 28 angiosperm families. In Primula, heterostyly is characterized by the cooccurrence of two complementary, self-incompatible floral morphs and is controlled by five genes clustered in the hemizygous, ca. 300-kb S locus. Here, we present the first chromosome-scale genome assembly of any heterostylous species, that of Primula veris (cowslip). By leveraging the high contiguity of the P. veris assembly and comparative genomic analyses, we demonstrated that the S-locus evolved via multiple, asynchronous gene duplications and independent gene translocations. Furthermore, we discovered a new whole-genome duplication in Ericales that is specific to the Primula lineage. We also propose a mechanism for the origin of S-locus hemizygosity via nonhomologous recombination involving the newly discovered two pairs of CFB genes flanking the S locus. Finally, we detected only weak signatures of degeneration in the S locus, as predicted for hemizygous supergenes. The present study provides a useful resource for future research addressing key questions on the evolution of supergenes in general and the S locus in particular: How do supergenes arise? What is the role of genome architecture in the evolution of complex adaptations? Is the molecular architecture of heterostyly supergenes across angiosperms similar to that of Primula?},
  language  = {en}
}
@misc{GarbusowNebeSommeretal.2019,
  author    = {Garbusow, Maria and Nebe, Stephan and Sommer, Christian and Kuitunen-Paul, S{\"o}ren and Sebold, Miriam and Schad, Daniel and Friedel, Eva and Veer, Ilya M. and Wittchen, Hans-Ulrich and Rapp, Michael A. and Ripke, Stephan and Walter, Henrik and Huys, Quentin J. M. and Schlagenhauf, Florian and Smolka, Michael N. and Heinz, Andreas},
  title     = {Pavlovian-To-Instrumental Transfer and Alcohol Consumption in Young Male Social Drinkers},
  series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  journal   = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe},
  number    = {841},
  issn      = {1866-8364},
  doi       = {10.25932/publishup-47328},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-473280},
  pages     = {14},
  year      = {2019},
  abstract  = {In animals and humans, behavior can be influenced by irrelevant stimuli, a phenomenon called Pavlovian-to-instrumental transfer (PIT). In subjects with substance use disorder, PIT is even enhanced with functional activation in the nucleus accumbens (NAcc) and amygdala. While we observed enhanced behavioral and neural PIT effects in alcohol-dependent subjects, we here aimed to determine whether behavioral PIT is enhanced in young men with high-risk compared to low-risk drinking and subsequently related functional activation in an a-priori region of interest encompassing the NAcc and amygdala and related to polygenic risk for alcohol consumption. A representative sample of 18-year old men (n = 1937) was contacted: 445 were screened, 209 assessed: resulting in 191 valid behavioral, 139 imaging and 157 genetic datasets. None of the subjects fulfilled criteria for alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-IV-TextRevision (DSM-IV-TR). We measured how instrumental responding for rewards was influenced by background Pavlovian conditioned stimuli predicting action-independent rewards and losses. Behavioral PIT was enhanced in high-compared to low-risk drinkers (b = 0.09, SE = 0.03, z = 2.7, p < 0.009). Across all subjects, we observed PIT-related neural blood oxygen level-dependent (BOLD) signal in the right amygdala (t = 3.25, p(SVC) = 0.04, x = 26, y = -6, z = -12), but not in NAcc. The strength of the behavioral PIT effect was positively correlated with polygenic risk for alcohol consumption (r(s) = 0.17, p = 0.032). We conclude that behavioral PIT and polygenic risk for alcohol consumption might be a biomarker for a subclinical phenotype of risky alcohol consumption, even if no drug-related stimulus is present. The association between behavioral PIT effects and the amygdala might point to habitual processes related to out PIT task. In non-dependent young social drinkers, the amygdala rather than the NAcc is activated during PIT; possible different involvement in association with disease trajectory should be investigated in future studies.},
  language  = {en}
}
@article{SchadGarbusowFriedeletal.2018,
  author    = {Schad, Daniel and Garbusow, Maria and Friedel, Eva and Sommer, Christian and Sebold, Miriam and H{\"a}gele, Claudia and Bernhardt, Nadine and Nebe, Stephan and Kuitunen-Paul, S{\"o}ren and Liu, Shuyan and Eichmann, Uta and Beck, Anne and Wittchen, Hans-Ulrich and Walter, Henrik and Sterzer, Philipp and Zimmermann, Ulrich S. and Smolka, Michael N. and Schlagenhauf, Florian and Huys, Quentin J. M. and Heinz, Andreas and Rapp, Michael A.},
  title     = {Neural correlates of instrumental responding in the context of alcohol-related cues index disorder severity and relapse risk},
  series = {European archives of psychiatry and clinical neuroscience : official organ of the German Society for Biological Psychiatry},
  volume    = {269},
  journal   = {European archives of psychiatry and clinical neuroscience : official organ of the German Society for Biological Psychiatry},
  number    = {3},
  publisher = {Springer},
  address   = {Heidelberg},
  issn      = {0940-1334},
  doi       = {10.1007/s00406-017-0860-4},
  pages     = {295 -- 308},
  year      = {2018},
  abstract  = {The influence of Pavlovian conditioned stimuli on ongoing behavior may contribute to explaining how alcohol cues stimulate drug seeking and intake. Using a Pavlovian-instrumental transfer task, we investigated the effects of alcohol-related cues on approach behavior (i.e., instrumental response behavior) and its neural correlates, and related both to the relapse after detoxification in alcohol-dependent patients. Thirty-one recently detoxified alcohol-dependent patients and 24 healthy controls underwent instrumental training, where approach or non-approach towards initially neutral stimuli was reinforced by monetary incentives. Approach behavior was tested during extinction with either alcohol-related or neutral stimuli (as Pavlovian cues) presented in the background during functional magnetic resonance imaging (fMRI). Patients were subsequently followed up for 6 months. We observed that alcohol-related background stimuli inhibited the approach behavior in detoxified alcohol-dependent patients (t = -3.86, p < .001), but not in healthy controls (t = -0.92, p = .36). This behavioral inhibition was associated with neural activation in the nucleus accumbens (NAcc) (t((30)) = 2.06, p < .05). Interestingly, both the effects were only present in subsequent abstainers, but not relapsers and in those with mild but not severe dependence. Our data show that alcohol-related cues can acquire inhibitory behavioral features typical of aversive stimuli despite being accompanied by a stronger NAcc activation, suggesting salience attribution. The fact that these findings are restricted to abstinence and milder illness suggests that they may be potential resilience factors.},
  language  = {en}
}
@article{GarbusowNebeSommeretal.2019,
  author    = {Garbusow, Maria and Nebe, Stephan and Sommer, Christian and Kuitunen-Paul, S{\"o}ren and Sebold, Miriam and Schad, Daniel and Friedel, Eva and Veer, Ilya M. and Wittchen, Hans-Ulrich and Rapp, Michael A. and Ripke, Stephan and Walter, Henrik and Huys, Quentin J. M. and Schlagenhauf, Florian and Smolka, Michael N. and Heinz, Andreas},
  title     = {Pavlovian-To-Instrumental Transfer and Alcohol Consumption in Young Male Social Drinkers},
  series = {Journal of Clinical Medicine},
  volume    = {8},
  journal   = {Journal of Clinical Medicine},
  number    = {8},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2077-0383},
  doi       = {10.3390/jcm8081188},
  pages     = {14},
  year      = {2019},
  abstract  = {In animals and humans, behavior can be influenced by irrelevant stimuli, a phenomenon called Pavlovian-to-instrumental transfer (PIT). In subjects with substance use disorder, PIT is even enhanced with functional activation in the nucleus accumbens (NAcc) and amygdala. While we observed enhanced behavioral and neural PIT effects in alcohol-dependent subjects, we here aimed to determine whether behavioral PIT is enhanced in young men with high-risk compared to low-risk drinking and subsequently related functional activation in an a-priori region of interest encompassing the NAcc and amygdala and related to polygenic risk for alcohol consumption. A representative sample of 18-year old men (n = 1937) was contacted: 445 were screened, 209 assessed: resulting in 191 valid behavioral, 139 imaging and 157 genetic datasets. None of the subjects fulfilled criteria for alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-IV-TextRevision (DSM-IV-TR). We measured how instrumental responding for rewards was influenced by background Pavlovian conditioned stimuli predicting action-independent rewards and losses. Behavioral PIT was enhanced in high-compared to low-risk drinkers (b = 0.09, SE = 0.03, z = 2.7, p < 0.009). Across all subjects, we observed PIT-related neural blood oxygen level-dependent (BOLD) signal in the right amygdala (t = 3.25, p(SVC) = 0.04, x = 26, y = -6, z = -12), but not in NAcc. The strength of the behavioral PIT effect was positively correlated with polygenic risk for alcohol consumption (r(s) = 0.17, p = 0.032). We conclude that behavioral PIT and polygenic risk for alcohol consumption might be a biomarker for a subclinical phenotype of risky alcohol consumption, even if no drug-related stimulus is present. The association between behavioral PIT effects and the amygdala might point to habitual processes related to out PIT task. In non-dependent young social drinkers, the amygdala rather than the NAcc is activated during PIT; possible different involvement in association with disease trajectory should be investigated in future studies.},
  language  = {en}
}
@article{GarbusowSchadSeboldetal.2016,
  author    = {Garbusow, Maria and Schad, Daniel and Sebold, Miriam and Friedel, Eva and Bernhardt, Nadine and Koch, Stefan P. and Steinacher, Bruno and Kathmann, Norbert and Geurts, Dirk E. M. and Sommer, Christian and Mueller, Dirk K. and Nebe, Stephan and Paul, Soeren and Wittchen, Hans-Ulrich and Zimmermann, Ulrich S. and Walter, Henrik and Smolka, Michael N. and Sterzer, Philipp and Rapp, Michael A. and Huys, Quentin J. M. and Schlagenhauf, Florian and Heinz, Andreas},
  title     = {Pavlovian-to-instrumental transfer effects in the nucleus accumbens relate to relapse in alcohol dependence},
  series = {Addiction biology},
  volume    = {21},
  journal   = {Addiction biology},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {1355-6215},
  doi       = {10.1111/adb.12243},
  pages     = {719 -- 731},
  year      = {2016},
  abstract  = {In detoxified alcohol-dependent patients, alcohol-related stimuli can promote relapse. However, to date, the mechanisms by which contextual stimuli promote relapse have not been elucidated in detail. One hypothesis is that such contextual stimuli directly stimulate the motivation to drink via associated brain regions like the ventral striatum and thus promote alcohol seeking, intake and relapse. Pavlovian-to-Instrumental-Transfer (PIT) may be one of those behavioral phenomena contributing to relapse, capturing how Pavlovian conditioned (contextual) cues determine instrumental behavior (e.g. alcohol seeking and intake). We used a PIT paradigm during functional magnetic resonance imaging to examine the effects of classically conditioned Pavlovian stimuli on instrumental choices in n=31 detoxified patients diagnosed with alcohol dependence and n=24 healthy controls matched for age and gender. Patients were followed up over a period of 3 months. We observed that (1) there was a significant behavioral PIT effect for all participants, which was significantly more pronounced in alcohol-dependent patients; (2) PIT was significantly associated with blood oxygen level-dependent (BOLD) signals in the nucleus accumbens (NAcc) in subsequent relapsers only; and (3) PIT-related NAcc activation was associated with, and predictive of, critical outcomes (amount of alcohol intake and relapse during a 3 months follow-up period) in alcohol-dependent patients. These observations show for the first time that PIT-related BOLD signals, as a measure of the influence of Pavlovian cues on instrumental behavior, predict alcohol intake and relapse in alcohol dependence.},
  language  = {en}
}
@unpublished{AcharyaActisAghajanietal.2013,
  author    = {Acharya, B. S. and Actis, M. and Aghajani, T. and Agnetta, G. and Aguilar, J. and Aharonian, Felix A. and Ajello, M. and Akhperjanian, A. G. and Alcubierre, M. and Aleksic, J. and Alfaro, R. and Aliu, E. and Allafort, A. J. and Allan, D. and Allekotte, I. and Amato, E. and Anderson, J. and Ang{\"u}ner, Ekrem Oǧuzhan and Antonelli, L. A. and Antoranz, P. and Aravantinos, A. and Arlen, T. and Armstrong, T. and Arnaldi, H. and Arrabito, L. and Asano, K. and Ashton, T. and Asorey, H. G. and Awane, Y. and Baba, H. and Babic, A. and Baby, N. and Baehr, J. and Bais, A. and Baixeras, C. and Bajtlik, S. and Balbo, M. and Balis, D. and Balkowski, C. and Bamba, A. and Bandiera, R. and Barber, A. and Barbier, C. and Barcelo, M. and Barnacka, Anna and Barnstedt, J{\"u}rgen and Barres de Almeida, U. and Barrio, J. A. and Basili, A. and Basso, S. and Bastieri, D. and Bauer, C. and Baushev, Anton N. and Becerra Gonzalez, J. and Becherini, Yvonne and Bechtol, K. C. and Tjus, J. Becker and Beckmann, Volker and Bednarek, W. and Behera, B. and Belluso, M. and Benbow, W. and Berdugo, J. and Berger, K. and Bernard, F. and Bernardino, T. and Bernl{\"o}hr, K. and Bhat, N. and Bhattacharyya, S. and Bigongiari, C. and Biland, A. and Billotta, S. and Bird, T. and Birsin, E. and Bissaldi, E. and Biteau, Jonathan and Bitossi, M. and Blake, S. and Blanch Bigas, O. and Blasi, P. and Bobkov, A. A. and Boccone, V. and Boettcher, Markus and Bogacz, L. and Bogart, J. and Bogdan, M. and Boisson, Catherine and Boix Gargallo, J. and Bolmont, J. and Bonanno, G. and Bonardi, A. and Bonev, T. and Bonifacio, P. and Bonnoli, G. and Bordas, Pol and Borgland, A. W. and Borkowski, Janett and Bose, R. and Botner, O. and Bottani, A. and Bouchet, L. and Bourgeat, M. and Boutonnet, C. and Bouvier, A. and Brau-Nogue, S. and Braun, I. and Bretz, T. and Briggs, M. S. and Bringmann, T. and Brook, P. and Brun, Pierre and Brunetti, L. and Buanes, T. and Buckley, J. H. and Buehler, R. and Bugaev, V. and Bulgarelli, A. and Bulik, Tomasz and Busetto, G. and Buson, S. and Byrum, K. and Cailles, M. and Cameron, R. A. and Camprecios, J. and Canestrari, R. and Cantu, S. and Capalbi, M. and Caraveo, P. A. and Carmona, E. and Carosi, A. and Carr, John and Carton, P. H. and Casanova, Sabrina and Casiraghi, M. and Catalano, O. and Cavazzani, S. and Cazaux, S. and Cerruti, M. and Chabanne, E. and Chadwick, Paula M. and Champion, C. and Chen, Andrew and Chiang, J. and Chiappetti, L. and Chikawa, M. and Chitnis, V. R. and Chollet, F. and Chudoba, J. and Cieslar, M. and Cillis, A. N. and Cohen-Tanugi, J. and Colafrancesco, Sergio and Colin, P. and Calome, J. and Colonges, S. and Compin, M. and Conconi, P. and Conforti, V. and Connaughton, V. and Conrad, Jan and Contreras, J. L. and Coppi, P. and Corona, P. and Corti, D. and Cortina, J. and Cossio, L. and Costantini, H. and Cotter, G. and Courty, B. and Couturier, S. and Covino, S. and Crimi, G. and Criswell, S. J. and Croston, J. and Cusumano, G. and Dafonseca, M. and Dale, O. and Daniel, M. and Darling, J. and Davids, I. and Dazzi, F. and De Angelis, A. and De Caprio, V. and De Frondat, F. and de Gouveia Dal Pino, E. M. and de la Calle, I. and De La Vega, G. A. and Lopez, R. de los Reyes and De Lotto, B. and De Luca, A. and de Mello Neto, J. R. T. and de Naurois, M. and de Oliveira, Y. and de Ona Wilhelmi, E. and de Souza, V. and Decerprit, G. and Decock, G. and Deil, C. and Delagnes, E. and Deleglise, G. and Delgado, C. and Della Volpe, D. and Demange, P. and Depaola, G. and Dettlaff, A. and Di Paola, A. and Di Pierro, F. and Diaz, C. and Dick, J. and Dickherber, R. and Dickinson, H. and Diez-Blanco, V. and Digel, S. and Dimitrov, D. and Disset, G. and Djannati-Ata{\"i}, A. and Doert, M. and Dohmke, M. and Domainko, W. and Prester, Dijana Dominis and Donat, A. and Dorner, D. and Doro, M. and Dournaux, J-L. and Drake, G. and Dravins, D. and Drury, L. and Dubois, F. and Dubois, R. and Dubus, G. and Dufour, C. and Dumas, D. and Dumm, J. and Durand, D. and Dyks, J. and Dyrda, M. and Ebr, J. and Edy, E. and Egberts, Kathrin and Eger, P. and Einecke, S. and Eleftheriadis, C. and Elles, S. and Emmanoulopoulos, D. and Engelhaupt, D. and Enomoto, R. and Ernenwein, J-P and Errando, M. and Etchegoyen, A. and Evans, P. and Falcone, A. and Fantinel, D. and Farakos, K. and Farnier, C. and Fasola, G. and Favill, B. and Fede, E. and Federici, S. and Fegan, S. and Feinstein, F. and Ferenc, D. and Ferrando, P. and Fesquet, M. and Fiasson, A. and Fillin-Martino, E. and Fink, D. and Finley, C. and Finley, J. P. and Fiorini, M. and Firpo Curcoll, R. and Flores, H. and Florin, D. and Focke, W. and Foehr, C. and Fokitis, E. and Font, L. and Fontaine, G. and Fornasa, M. and Foerster, A. and Fortson, L. and Fouque, N. and Franckowiak, A. and Fransson, C. and Fraser, G. and Frei, R. and Albuquerque, I. F. M. and Fresnillo, L. and Fruck, C. and Fujita, Y. and Fukazawa, Y. and Fukui, Y. and Funk, S. and Gaebele, W. and Gabici, S. and Gabriele, R. and Gadola, A. and Galante, N. and Gall, D. and Gallant, Y. and Gamez-Garcia, J. and Garcia, B. and Garcia Lopez, R. and Gardiol, D. and Garrido, D. and Garrido, L. and Gascon, D. and Gaug, M. and Gaweda, J. and Gebremedhin, L. and Geffroy, N. and Gerard, L. and Ghedina, A. and Ghigo, M. and Giannakaki, E. and Gianotti, F. and Giarrusso, S. and Giavitto, G. and Giebels, B. and Gika, V. and Giommi, P. and Girard, N. and Giro, E. and Giuliani, A. and Glanzman, T. and Glicenstein, J. -F. and Godinovic, N. and Golev, V. and Gomez Berisso, M. and Gomez-Ortega, J. and Gonzalez, M. M. and Gonzalez, A. and Gonzalez, F. and Gonzalez Munoz, A. and Gothe, K. S. and Gougerot, M. and Graciani, R. and Grandi, P. and Granena, F. and Granot, J. and Grasseau, G. and Gredig, R. and Green, A. and Greenshaw, T. and Gregoire, T. and Grimm, O. and Grube, J. and Grudzinska, M. and Gruev, V. and Gruenewald, S. and Grygorczuk, J. and Guarino, V. and Gunji, S. and Gyuk, G. and Hadasch, D. and Hagiwara, R. and Hahn, J. and Hakansson, N. and Hallgren, A. and Hamer Heras, N. and Hara, S. and Hardcastle, M. J. and Harris, J. and Hassan, T. and Hatanaka, K. and Haubold, T. and Haupt, A. and Hayakawa, T. and Hayashida, M. and Heller, R. and Henault, F. and Henri, G. and Hermann, G. and Hermel, R. and Herrero, A. and Hidaka, N. and Hinton, J. and Hoffmann, D. and Hofmann, W. and Hofverberg, P. and Holder, J. and Horns, D. and Horville, D. and Houles, J. and Hrabovsky, M. and Hrupec, D. and Huan, H. and Huber, B. and Huet, J. -M. and Hughes, G. and Humensky, T. B. and Huovelin, J. and Ibarra, A. and Illa, J. M. and Impiombato, D. and Incorvaia, S. and Inoue, S. and Inoue, Y. and Ioka, K. and Ismailova, E. and Jablonski, C. and Jacholkowska, A. and Jamrozy, M. and Janiak, M. and Jean, P. and Jeanney, C. and Jimenez, J. J. and Jogler, T. and Johnson, T. and Journet, L. and Juffroy, C. and Jung, I. and Kaaret, P. and Kabuki, S. and Kagaya, M. and Kakuwa, J. and Kalkuhl, C. and Kankanyan, R. and Karastergiou, A. and Kaercher, K. and Karczewski, M. and Karkar, S. and Kasperek, Aci. and Kastana, D. and Katagiri, H. and Kataoka, J. and Katarzynski, K. and Katz, U. and Kawanaka, N. and Kellner-Leidel, B. and Kelly, H. and Kendziorra, E. and Khelifi, B. and Kieda, D. B. and Kifune, T. and Kihm, T. and Kishimoto, T. and Kitamoto, K. and Kluzniak, W. and Knapic, C. and Knapp, J. w and Knoedlseder, J. and Koeck, F. and Kocot, J. and Kodani, K. and Koehne, J. -H. and Kohri, K. and Kokkotas, K. and Kolitzus, D. and Komin, N. and Kominis, I. and Konno, Y. and Koeppel, H. and Korohoda, P. and Kosack, K. and Koss, G. and Kossakowski, R. and Kostka, P. and Koul, R. and Kowal, G. and Koyama, S. and Koziol, J. and Kraehenbuehl, T. and Krause, J. and Krawzcynski, H. and Krennrich, F. and Krepps, A. and Kretzschmann, A. and Krobot, R. and Krueger, P. and Kubo, H. and Kudryavtsev, V. A. and Kushida, J. and Kuznetsov, A. and La Barbera, A. and La Palombara, N. and La Parola, V. and La Rosa, G. and Lacombe, K. and Lamanna, G. and Lande, J. and Languignon, D. and Lapington, J. and Laporte, P. and Lavalley, C. and Le Flour, T. and Le Padellec, A. and Lee, S. -H. and Lee, W. H. and Leigui de Oliveira, M. A. and Lelas, D. and Lenain, J. -P. and Leopold, D. J. and Lerch, T. and Lessio, L. and Lieunard, B. and Lindfors, E. and Liolios, A. and Lipniacka, A. and Lockart, H. and Lohse, T. and Lombardi, S. and Lopatin, A. and Lopez, M. and Lopez-Coto, R. and Lopez-Oramas, A. and Lorca, A. and Lorenz, E. and Lubinski, P. and Lucarelli, F. and Luedecke, H. and Ludwin, J. and Luque-Escamilla, P. L. and Lustermann, W. and Luz, O. and Lyard, E. and Maccarone, M. C. and Maccarone, T. J. and Madejski, G. M. and Madhavan, A. and Mahabir, M. and Maier, G. and Majumdar, P. and Malaguti, G. and Maltezos, S. and Manalaysay, A. and Mancilla, A. and Mandat, D. and Maneva, G. and Mangano, A. and Manigot, P. and Mannheim, K. and Manthos, I. and Maragos, N. and Marcowith, Alexandre and Mariotti, M. and Marisaldi, M. and Markoff, S. and Marszalek, A. and Martens, C. and Marti, J. and Martin, J-M. and Martin, P. and Martinez, G. and Martinez, F. and Martinez, M. and Masserot, A. and Mastichiadis, A. and Mathieu, A. and Matsumoto, H. and Mattana, F. and Mattiazzo, S. and Maurin, G. and Maxfield, S. and Maya, J. and Mazin, D. and Mc Comb, L. and McCubbin, N. and McHardy, I. and McKay, R. and Medina, C. and Melioli, C. and Melkumyan, D. and Mereghetti, S. and Mertsch, P. and Meucci, M. and Michalowski, J. and Micolon, P. and Mihailidis, A. and Mineo, T. and Minuti, M. and Mirabal, N. and Mirabel, F. and Miranda, J. M. and Mirzoyan, R. and Mizuno, T. and Moal, B. and Moderski, R. and Mognet, I. and Molinari, E. and Molinaro, M. and Montaruli, T. and Monteiro, I. and Moore, P. and Moralejo Olaizola, A. and Mordalska, M. and Morello, C. and Mori, K. and Mottez, F. and Moudden, Y. and Moulin, Emmanuel and Mrusek, I. and Mukherjee, R. and Munar-Adrover, P. and Muraishi, H. and Murase, K. and Murphy, A. and Nagataki, S. and Naito, T. and Nakajima, D. and Nakamori, T. and Nakayama, K. and Naumann, C. L. and Naumann, D. and Naumann-Godo, M. and Nayman, P. and Nedbal, D. and Neise, D. and Nellen, L. and Neustroev, V. and Neyroud, N. and Nicastro, L. and Nicolau-Kuklinski, J. and Niedzwiecki, A. and Niemiec, J. and Nieto, D. and Nikolaidis, A. and Nishijima, K. and Nolan, S. and Northrop, R. and Nosek, D. and Nowak, N. and Nozato, A. and O'Brien, P. and Ohira, Y. and Ohishi, M. and Ohm, S. and Ohoka, H. and Okuda, T. and Okumura, A. and Olive, J. -F. and Ong, R. A. and Orito, R. and Orr, M. and Osborne, J. and Ostrowski, M. and Otero, L. A. and Otte, N. and Ovcharov, E. and Oya, I. and Ozieblo, A. and Padilla, L. and Paiano, S. and Paillot, D. and Paizis, A. and Palanque, S. and Palatka, M. and Pallota, J. and Panagiotidis, K. and Panazol, J. -L. and Paneque, D. and Panter, M. and Paoletti, R. and Papayannis, Alexandros and Papyan, G. and Paredes, J. M. and Pareschi, G. and Parks, G. and Parraud, J. -M. and Parsons, D. and Arribas, M. Paz and Pech, M. and Pedaletti, G. and Pelassa, V. and Pelat, D. and Perez, M. D. C. and Persic, M. and Petrucci, P-O and Peyaud, B. and Pichel, A. and Pita, S. and Pizzolato, F. and Platos, L. and Platzer, R. and Pogosyan, L. and Pohl, M. and Pojmanski, G. and Ponz, J. D. and Potter, W. and Poutanen, J. and Prandini, E. and Prast, J. and Preece, R. and Profeti, F. and Prokoph, H. and Prouza, M. and Proyetti, M. and Puerto-Gimenez, I. and Puehlhofer, G. and Puljak, I. and Punch, M. and Pyziol, R. and Quel, E. J. and Quinn, J. and Quirrenbach, A. and Racero, E. and Rajda, P. J. and Ramon, P. and Rando, R. and Rannot, R. C. and Rataj, M. and Raue, M. and Reardon, P. and Reimann, O. and Reimer, A. and Reimer, O. and Reitberger, K. and Renaud, M. and Renner, S. and Reville, B. and Rhode, W. and Ribo, M. and Ribordy, M. and Richer, M. G. and Rico, J. and Ridky, J. and Rieger, F. and Ringegni, P. and Ripken, J. and Ristori, P. R. and Riviere, A. and Rivoire, S. and Rob, L. and Roeser, U. and Rohlfs, R. and Rojas, G. and Romano, Patrizia and Romaszkan, W. and Romero, G. E. and Rosen, S. and Lees, S. Rosier and Ross, D. and Rouaix, G. and Rousselle, J. and Rousselle, S. and Rovero, A. C. and Roy, F. and Royer, S. and Rudak, B. and Rulten, C. and Rupinski, M. and Russo, F. and Ryde, F. and Sacco, B. and Saemann, E. O. and Saggion, A. and Safiakian, V. and Saito, K. and Saito, T. and Saito, Y. and Sakaki, N. and Sakonaka, R. and Salini, A. and Sanchez, F. and Sanchez-Conde, M. and Sandoval, A. and Sandaker, H. and Sant'Ambrogio, E. and Santangelo, Andrea and Santos, E. M. and Sanuy, A. and Sapozhnikov, L. and Sarkar, S. and Sartore, N. and Sasaki, H. and Satalecka, K. and Sawada, M. and Scalzotto, V. and Scapin, V. and Scarcioffolo, M. and Schafer, J. and Schanz, T. and Schlenstedt, S. and Schlickeiser, R. and Schmidt, T. and Schmoll, J. and Schovanek, P. and Schroedter, M. and Schultz, C. and Schultze, J. and Schulz, A. and Schure, K. and Schwab, T. and Schwanke, U. and Schwarz, J. and Schwarzburg, S. and Schweizer, T. and Schwemmer, S. and Segreto, A. and Seiradakis, J. -H. and Sembroski, G. H. and Seweryn, K. and Sharma, M. and Shayduk, M. and Shellard, R. C. and Shi, J. and Shibata, T. and Shibuya, A. and Shum, E. and Sidoli, L. and Sidz, M. and Sieiro, J. and Sikora, M. and Silk, J. and Sillanpaa, A. and Singh, B. B. and Sitarek, J. and Skole, C. and Smareglia, R. and Smith, A. and Smith, D. and Smith, J. and Smith, N. and Sobczynska, D. and Sol, H. and Sottile, G. and Sowinski, M. and Spanier, F. and Spiga, D. and Spyrou, S. and Stamatescu, V. and Stamerra, A. and Starling, R. and Stawarz, L. and Steenkamp, R. and Stegmann, Christian and Steiner, S. and Stergioulas, N. and Sternberger, R. and Sterzel, M. and Stinzing, F. and Stodulski, M. and Straumann, U. and Strazzeri, E. and Stringhetti, L. and Suarez, A. and Suchenek, M. and Sugawara, R. and Sulanke, K. -H. and Sun, S. and Supanitsky, A. D. and Suric, T. and Sutcliffe, P. and Sykes, J. and Szanecki, M. and Szepieniec, T. and Szostek, A. and Tagliaferri, G. and Tajima, H. and Takahashi, H. and Takahashi, K. and Takalo, L. and Takami, H. and Talbot, C. and Tammi, J. and Tanaka, M. and Tanaka, S. and Tasan, J. and Tavani, M. and Tavernet, J. -P. and Tejedor, L. A. and Telezhinsky, Igor O. and Temnikov, P. and Tenzer, C. and Terada, Y. and Terrier, R. and Teshima, M. and Testa, V. and Tezier, D. and Thuermann, D. and Tibaldo, L. and Tibolla, O. and Tiengo, A. and Tluczykont, M. and Todero Peixoto, C. J. and Tokanai, F. and Tokarz, M. and Toma, K. and Torii, K. and Tornikoski, M. and Torres, D. F. and Torres, M. and Tosti, G. and Totani, T. and Toussenel, C. and Tovmassian, G. and Travnicek, P. and Trifoglio, M. and Troyano, I. and Tsinganos, K. and Ueno, H. and Umehara, K. and Upadhya, S. S. and Usher, T. and Uslenghi, M. and Valdes-Galicia, J. F. and Vallania, P. and Vallejo, G. and van Driel, W. and van Eldik, C. and Vandenbrouke, J. and Vanderwalt, J. and Vankov, H. and Vasileiadis, G. and Vassiliev, V. and Veberic, D. and Vegas, I. and Vercellone, S. and Vergani, S. and Veyssiere, C. and Vialle, J. P. and Viana, A. and Videla, M. and Vincent, P. and Vincent, S. and Vink, J. and Vlahakis, N. and Vlahos, L. and Vogler, P. and Vollhardt, A. and von Gunten, H. P. and Vorobiov, S. and Vuerli, C. and Waegebaert, V. and Wagner, R. and Wagner, R. G. and Wagner, S. and Wakely, S. P. and Walter, R. and Walther, T. and Warda, K. and Warwick, R. and Wawer, P. and Wawrzaszek, R. and Webb, N. and Wegner, P. and Weinstein, A. and Weitzel, Q. and Welsing, R. and Werner, M. and Wetteskind, H. and White, R. and Wierzcholska, A. and Wiesand, S. and Wilkinson, M. and Williams, D. A. and Willingale, R. and Winiarski, K. and Wischnewski, R. and Wisniewski, L. and Wood, M. and Woernlein, A. and Xiong, Q. and Yadav, K. K. and Yamamoto, H. and Yamamoto, T. and Yamazaki, R. and Yanagita, S. and Yebras, J. M. and Yelos, D. and Yoshida, A. and Yoshida, T. and Yoshikoshi, T. and Zabalza, V. and Zacharias, M. and Zajczyk, A. and Zanin, R. and Zdziarski, A. and Zech, Alraune and Zhao, A. and Zhou, X. and Zietara, K. and Ziolkowski, J. and Ziolkowski, P. and Zitelli, V. and Zurbach, C. and Zychowski, P.},
  title     = {Introducing the CTA concept},
  series = {Astroparticle physics},
  volume    = {43},
  journal   = {Astroparticle physics},
  number    = {2},
  publisher = {Elsevier},
  address   = {Amsterdam},
  organization    = {CTA Consortium},
  issn      = {0927-6505},
  doi       = {10.1016/j.astropartphys.2013.01.007},
  pages     = {3 -- 18},
  year      = {2013},
  abstract  = {The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project.},
  language  = {en}
}