@article{PehlivanogluWuertzKozakHeideretal.2019,
  author    = {Pehlivanoglu, Tuna and W{\"u}rtz-Kozak, Karin and Heider, Franziska and Sauer, Daniel and Wanke-Jellinek, Lorenz and Mayer, Michael and Mehren, Christoph},
  title     = {Clinical and Radiographic Outcome of Patients With Cervical Spondylotic Myelopathy Undergoing Total Disc Replacement},
  series = {SPINE},
  volume    = {44},
  journal   = {SPINE},
  number    = {20},
  publisher = {Lippincott Williams \& Wilkins},
  address   = {Philadelphia},
  issn      = {0362-2436},
  doi       = {10.1097/BRS.0000000000003079},
  pages     = {1403 -- 1411},
  year      = {2019},
  abstract  = {Study Design. A nonrandomized, prospective, and single-center clinical trial. Objective. The aim of this study was to investigate the clinical and radiographic efficacy of ProDisc Vivo cervical total disc replacement (cTDR) in patients with clinical and radiographic documented cervical spondylotic myelopathy (CSM), due to degenerative changes at the index level. Summary of Background Data. Decompression and fusion is still the gold standard in patients with cervical myelopathy. Very limited data are available regarding the application of cTDR in patients with clinical and radiological documented CSM in context of clinical and radiographic outcomes. Methods. Clinical outcome scores included the Neck Disability Index (NDI), Visual Analogue Scale (VAS), arm and neck pain self-assessment questionnaires as well as the Nurick grade and the Japanese Orthopaedic Association (JOA) score. The radiological outcome included the range of motion (ROM), the segmental and global (C2-C7) lordosis, and the occurrence of heterotopic ossifications. Results. Eighteen consecutive patients (10 males, 8 females) with documented clinical and radiological signs of myelopathy were included in this investigation. The study population had a mean age of 52.4 years and a follow-up period of 20.3 months in average (range 3-48 months). The mean range ROM of the index level stayed consistent with 6.8 degrees preoperatively and 7.2 degrees (P = 0.578) at the last follow-up; the global lordosis in neutral position changed from 3.5 degrees to 14.2 degrees significantly (P = 0.005) in mean. The JOA score improved from 11.3 to 16.6 (P < 0.001) as well as the NDI 36.7 to 10.3 (P < 0.001) and the VAS score from 5.7/6.1 (arm/neck) to 1.3/2.0 (P P < 0.001). The mean Nurick grade was 1.33 preoperatively and dropped down in all cases to Nurick grade of 0 (P < 0.001). Conclusion. cTDR (with ProDisc Vivio) in patients with CSM yielded good clinical and radiographic outcomes and found as a reliable, safe, and motion-preserving surgical treatment option, although its indication is very limited due to numerous exclusion criteria.},
  language  = {en}
}
@article{MehrenWuertzKozakSaueretal.2019,
  author    = {Mehren, Christoph and Wuertz-Kozak, Karin and Sauer, Daniel and Hitzl, Wolfgang and Pehlivanoglu, Tuna and Heider, Franziska},
  title     = {Implant Design and the Anchoring Mechanism Influence the Incidence of Heterotopic Ossification in Cervical Total Disc Replacement at 2-year Follow-up},
  series = {Spine},
  volume    = {44},
  journal   = {Spine},
  number    = {21},
  publisher = {Lippincott Williams \& Wilkins},
  address   = {Philadelphia},
  issn      = {0362-2436},
  doi       = {10.1097/BRS.0000000000003098},
  pages     = {1471 -- 1480},
  year      = {2019},
  abstract  = {Study Design. A nonrandomized, prospective, and single-center clinical trial. Objective. The aim of this study was to determine whether the prosthesis design, and especially changes in the primary anchoring mechanism between the keel-based ProDisc C and the spike-based ProDisc Vivo, affects the frequency of heterotopic ossification (HO) formation over time. Summary of Background Data. The occurrence of motion-restricting HO as well as underlying risk factors has so far been a widely discussed, but not well understand phenomenon. The anchoring mechanism and the opening of the anterior cortex may be possible causes of this unwanted complication. Methods. Forty consecutive patients treated with the ProDisc C and 42 consecutive patients treated with the ProDisc Vivo were compared with respect to radiological and clinical outcome, with 2 years of follow-up. Clinical outcome scores included the Neck Disability Index (NDI), Visual Analogue Scale (VAS), and arm and neck pain self-assessment questionnaires. Radiological outcomes included the segmental lordosis and range of motion (ROM) of the index-segment as well as the occurrence of HO. Results. The clinical outcome parameters improved in both groups significantly. [ProDisc C: VAS arm and neck pain from 6.3 and 6.2 preoperatively to 0.7 and 1.3; NDI from 23.0 to 3.7; ProDisc Vivo: VAS arm and neck pain from 6.3 and 4.9 to 1.4 and 1.6, NDI from 34.1 to 8.7; 2-year follow-up (FU)]. The ProDisc Vivo cohort demonstrated a significantly lower incidence of HO than the ProDisc C group at 1-year FU (P = 0.0005) and 2-year FU (P = 0.005). Specifically, high-grade HO occurred in 9\% versus 31\%. Conclusion. These findings demonstrate that prosthesis designs that allow primary anchoring without violation of the cortical surface help to reduce the incidence of severe ossification, possibly affecting the functionality and mobility of the artificial disc device over of time.},
  language  = {en}
}
@article{MehrenHeiderSaueretal.2019,
  author    = {Mehren, Christoph and Heider, Franziska and Sauer, Daniel and Kothe, Ralph and Korge, Andreas and Hitzl, Wolfgang and W{\"u}rtz-Kozak, Karin},
  title     = {Clinical and radiological outcome of a new total cervical disc replacement design},
  series = {Spine},
  volume    = {44},
  journal   = {Spine},
  number    = {4},
  publisher = {Lippincott Williams \& Wilkins},
  address   = {Philadelphia},
  issn      = {0362-2436},
  doi       = {10.1097/BRS.0000000000002799},
  pages     = {E202 -- E210},
  year      = {2019},
  abstract  = {Study Design. A nonrandomized, prospective, and single- center clinical trial of the ProDisc Vivo prosthesis. Objective. The aim of this study was to investigate the clinical and radiological results of a refined total cervical disc replacement (cTDR), the ProDisc Vivo, with two years of follow-up (FU). The incidence of implant-related complications was recorded as a secondary outcome variable. Summary of Background Data. Previous generations of the ProDisc artificial cervical disc replacement generate high primary stability due to keel-based designs with opening of the anterior cortex during the implantation and subsequent high rates of heterotopic ossifications. Methods. Clinical outcome scores included the Neck Disability Index (NDI), Visual Analogue Scale (VAS), arm and neck pain self-assessment questionnaires. The radiological outcome included the range of motion (ROM) and the occurrence of heterotopic ossifications. The incidence of implant-related complications with new implant design was recorded as a secondary outcome variable. Results. A total of 55 patients received a single-level treatment with the ProDisc Vivo cTDR between C3/4 and C6/7, with a follow-up rate of 78\%. The clinical outcome scores improved in all parameters significantly (P 1/4 0.0001) (NDI: 68.3 -> 17.4; VAS arm: 6.3 -> 1.4; VAS neck: 4.9 -> 1.6). The ROM of the indexsegment did not show a significant change (P 1/4 0.26) (7.9 degrees -> 9.2 degrees). Heterotopic ossifications at the index segment was found as grade 0 in 5\%, grade 1 in 22\%, grade 2 in 10\%, grade 3 (with functional impairment of the prosthesis) in 7\%, and grade 4 in 3\% of the cases. We observed three implant-related complications (5.5\%), with two implant dislocations anteriorly and one low-grade infect. Conclusion. cTDR with ProDisc Vivo demonstrated a significant and sustained improvement of all clinical outcome parameters. A less invasive implantation mechanism with lower primary stability of the cTDR might be a reason for a higher dislocation rate than the keel-based previous generation ProDisc C.},
  language  = {en}
}
@article{SauerPoppDittfurthetal.2013,
  author    = {Sauer, David and Popp, Steffen and Dittfurth, Angela and Altdorff, Daniel and Dietrich, Peter and Paasche, Hendrik},
  title     = {Soil moisture assessment over an alpine hillslope with significant soil heterogeneity},
  series = {Vadose zone journal},
  volume    = {12},
  journal   = {Vadose zone journal},
  number    = {4},
  publisher = {Soil Science Society of America},
  address   = {Madison},
  issn      = {1539-1663},
  doi       = {10.2136/vzj2013.01.0009},
  pages     = {12},
  year      = {2013},
  abstract  = {We strive to assess soil water content on a well-studied slow-moving hillslope in Austria. In doing so, we employ time lapse mapping of bulk electrical conductivity using a geophysical electromagnetic induction system operated at low induction numbers. This information is complemented by the acquisition of soil samples for gravimetric water content analysis during one survey campaign. Simple visual soil sample analysis reveals that the upper material in the survey area is a spatially highly variable mixture of predominately sandy, silty, clayey and organic materials. Due to this heterogeneity, classical approaches of mapping soil moisture on the basis of stationary mapping of electrical conductivity variations are not successful. Also the time-lapse approach does not allow ruling out some of the ambiguity inherent to the linkage of bulk electrical conductivity to soil water content. However, indication is found that time-lapse measurements may have supportive capabilities to identify regions of low precipitation infiltration due to high soil saturation. Furthermore, the relationship between the mean electrical conductivity averaged over a full vegetation period and an already available ecological moisture map produced by vegetation analysis is found to resemble closely the relationship observed between gravimetric soil water content and electrical conductivity during the time of sample collection except for highly organic soils. This leads us to the assumption that the relative soil moisture distribution is temporarily stable except for those areas characterized by highly organic soils.},
  language  = {en}
}
@misc{RoesslerHiemerBachetal.2009,
  author    = {R{\"o}ßler, Dirk and Hiemer, Stephan and Bach, Christoph and Delavaud, Elise and Kr{\"u}ger, Frank and Ohrnberger, Matthias and Sauer, David and Scherbaum, Frank and Vollmer, Daniel},
  title     = {Small-aperture seismic array monitors Vogtland earthquake swarm in 2008/09},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-29185},
  year      = {2009},
  abstract  = {The most recent intense earthquake swarm in the Vogtland lasted from 6 October 2008 until January 2009. Greatest magnitudes exceeded M3.5 several times in October making it the greatest swarm since 1985/86. In contrast to the swarms in 1985 and 2000, seismic moment release was concentrated near swarm onset. Focal area and temporal evolution are similar to the swarm in 2000. Work hypothysis: uprising upper-mantle fluids trigger swarm earthquakes at low stress level. To monitor the seismicity, the University of Potsdam operated a small aperture seismic array at 10 km epicentral distance between 18 October 2008 and 18 March 2009. Consisting of 12 seismic stations and 3 additional microphones, the array is capable of detecting earthquakes from larger to very low magnitudes (M<-1) as well as associated air waves. We use array techniques to determine properties of the incoming wavefield: noise, direct P and S waves, and converted phases.},
  language  = {en}
}