@article{DeAngelisTatischeffGrenieretal.2018, author = {De Angelis, A. and Tatischeff, V. and Grenier, I. A. and McEnery, J. and Mallamaci, Manuela and Tavani, M. and Oberlack, U. and Hanlon, L. and Walter, R. and Argan, A. and Von Ballmoos, P. and Bulgarelli, A. and Bykov, A. and Hernanz, M. and Kanbach, G. and Kuvvetli, I. and Pearce, M. and Zdziarski, A. and Conrad, J. and Ghisellini, G. and Harding, A. and Isern, J. and Leising, M. and Longo, F. and Madejski, G. and Martinez, M. and Mazziotta, Mario Nicola and Paredes, J. M. and Pohl, Martin and Rando, R. and Razzano, M. and Aboudan, A. and Ackermann, M. and Addazi, A. and Ajello, M. and Albertus, C. and Alvarez, J. M. and Ambrosi, G. and Anton, S. and Antonelli, L. A. and Babic, A. and Baibussinov, B. and Balbom, M. and Baldini, L. and Balman, S. and Bambi, C. and Barres de Almeida, U. and Barrio, J. A. and Bartels, R. and Bastieri, D. and Bednarek, W. and Bernard, D. and Bernardini, E. and Bernasconi, T. and Bertucci, B. and Biland, A. and Bissaldi, E. and Boettcher, M. and Bonvicini, V. and Bosch-Ramon, V. and Bottacini, E. and Bozhilov, V. and Bretz, T. and Branchesi, M. and Brdar, V. and Bringmann, T. and Brogna, A. and Jorgensen, C. Budtz and Busetto, G. and Buson, S. and Busso, M. and Caccianiga, A. and Camera, S. and Campana, R. and Caraveo, P. and Cardillo, M. and Carlson, P. and Celestin, S. and Cermeno, M. and Chen, A. and Cheung, C. C. and Churazov, E. and Ciprini, S. and Coc, A. and Colafrancesco, S. and Coleiro, A. and Collmar, W. and Coppi, P. and Curado da Silva, R. and Cutini, S. and De Lotto, B. and de Martino, D. and De Rosa, A. and Del Santo, M. and Delgado, L. and Diehl, R. and Dietrich, S. and Dolgov, A. D. and Dominguez, A. and Prester, D. Dominis and Donnarumma, I. and Dorner, D. and Doro, M. and Dutra, M. and Elsaesser, D. and Fabrizio, M. and Fernandez-Barral, A. and Fioretti, V. and Foffano, L. and Formato, V. and Fornengo, N. and Foschini, L. and Franceschini, A. and Franckowiak, A. and Funk, S. and Fuschino, F. and Gaggero, D. and Galanti, G. and Gargano, F. and Gasparrini, D. and Gehrz, R. and Giammaria, P. and Giglietto, N. and Giommi, P. and Giordano, F. and Giroletti, M. and Ghirlanda, G. and Godinovic, N. and Gouiffes, C. and Grove, J. E. and Hamadache, C. and Hartmann, D. H. and Hayashida, M. and Hryczuk, A. and Jean, P. and Johnson, T. and Jose, J. and Kaufmann, S. and Khelifi, B. and Kiener, J. and Knodlseder, J. and Kolem, M. and Kopp, J. and Kozhuharov, V. and Labanti, C. and Lalkovski, S. and Laurent, P. and Limousin, O. and Linares, M. and Lindfors, E. and Lindner, M. and Liu, J. and Lombardi, S. and Loparco, F. and Lopez-Coto, R. and Lopez Moya, M. and Lott, B. and Lubrano, P. and Malyshev, D. and Mankuzhiyil, N. and Mannheim, K. and Marcha, M. J. and Marciano, A. and Marcote, B. and Mariotti, M. and Marisaldi, M. and McBreen, S. and Mereghetti, S. and Merle, A. and Mignani, R. and Minervini, G. and Moiseev, A. and Morselli, A. and Moura, F. and Nakazawa, K. and Nava, L. and Nieto, D. and Orienti, M. and Orio, M. and Orlando, E. and Orleanski, P. and Paiano, S. and Paoletti, R. and Papitto, A. and Pasquato, M. and Patricelli, B. and Perez-Garcia, M. A. and Persic, M. and Piano, G. and Pichel, A. and Pimenta, M. and Pittori, C. and Porter, T. and Poutanen, J. and Prandini, E. and Prantzos, N. and Produit, N. and Profumo, S. and Queiroz, F. S. and Raino, S. and Raklev, A. and Regis, M. and Reichardt, I. and Rephaeli, Y. and Rico, J. and Rodejohann, W. and Fernandez, G. Rodriguez and Roncadelli, M. and Roso, L. and Rovero, A. and Ruffini, R. and Sala, G. and Sanchez-Conde, M. A. and Santangelo, A. and Parkinson, P. Saz and Sbarrato, T. and Shearer, A. and Shellard, R. and Short, K. and Siegert, T. and Siqueira, C. and Spinelli, P. and Stamerra, A. and Starrfield, S. and Strong, A. and Strumke, I. and Tavecchio, F. and Taverna, R. and Terzic, T. and Thompson, D. J. and Tibolla, O. and Torres, D. F. and Turolla, R. and Ulyanov, A. and Ursi, A. and Vacchi, A. and Van den Abeele, J. and Vankova-Kirilovai, G. and Venter, C. and Verrecchia, F. and Vincent, P. and Wang, X. and Weniger, C. and Wu, X. and Zaharijas, G. and Zampieri, L. and Zane, S. and Zimmer, S. and Zoglauer, A.}, title = {Science with e-ASTROGAM A space mission for MeV-GeV gamma-ray astrophysics}, series = {Journal of High Energy Astrophysics}, volume = {19}, journal = {Journal of High Energy Astrophysics}, publisher = {Elsevier}, address = {Amsterdam}, organization = {e-ASTROGAM Collaboration}, issn = {2214-4048}, doi = {10.1016/j.jheap.2018.07.001}, pages = {1 -- 106}, year = {2018}, language = {en} } @article{WuttkeLiLietal.2019, author = {Wuttke, Matthias and Li, Yong and Li, Man and Sieber, Karsten B. and Feitosa, Mary F. and Gorski, Mathias and Tin, Adrienne and Wang, Lihua and Chu, Audrey Y. and Hoppmann, Anselm and Kirsten, Holger and Giri, Ayush and Chai, Jin-Fang and Sveinbjornsson, Gardar and Tayo, Bamidele O. and Nutile, Teresa and Fuchsberger, Christian and Marten, Jonathan and Cocca, Massimiliano and Ghasemi, Sahar and Xu, Yizhe and Horn, Katrin and Noce, Damia and Van der Most, Peter J. and Sedaghat, Sanaz and Yu, Zhi and Akiyama, Masato and Afaq, Saima and Ahluwalia, Tarunveer Singh and Almgren, Peter and Amin, Najaf and Arnlov, Johan and Bakker, Stephan J. L. and Bansal, Nisha and Baptista, Daniela and Bergmann, Sven and Biggs, Mary L. and Biino, Ginevra and Boehnke, Michael and Boerwinkle, Eric and Boissel, Mathilde and B{\"o}ttinger, Erwin and Boutin, Thibaud S. and Brenner, Hermann and Brumat, Marco and Burkhardt, Ralph and Butterworth, Adam S. and Campana, Eric and Campbell, Archie and Campbell, Harry and Canouil, Mickael and Carroll, Robert J. and Catamo, Eulalia and Chambers, John C. and Chee, Miao-Ling and Chee, Miao-Li and Chen, Xu and Cheng, Ching-Yu and Cheng, Yurong and Christensen, Kaare and Cifkova, Renata and Ciullo, Marina and Concas, Maria Pina and Cook, James P. and Coresh, Josef and Corre, Tanguy and Sala, Cinzia Felicita and Cusi, Daniele and Danesh, John and Daw, E. Warwick and De Borst, Martin H. and De Grandi, Alessandro and De Mutsert, Renee and De Vries, Aiko P. J. and Degenhardt, Frauke and Delgado, Graciela and Demirkan, Ayse and Di Angelantonio, Emanuele and Dittrich, Katalin and Divers, Jasmin and Dorajoo, Rajkumar and Eckardt, Kai-Uwe and Ehret, Georg and Elliott, Paul and Endlich, Karlhans and Evans, Michele K. and Felix, Janine F. and Foo, Valencia Hui Xian and Franco, Oscar H. and Franke, Andre and Freedman, Barry I. and Freitag-Wolf, Sandra and Friedlander, Yechiel and Froguel, Philippe and Gansevoort, Ron T. and Gao, He and Gasparini, Paolo and Gaziano, J. Michael and Giedraitis, Vilmantas and Gieger, Christian and Girotto, Giorgia and Giulianini, Franco and Gogele, Martin and Gordon, Scott D. and Gudbjartsson, Daniel F. and Gudnason, Vilmundur and Haller, Toomas and Hamet, Pavel and Harris, Tamara B. and Hartman, Catharina A. and Hayward, Caroline and Hellwege, Jacklyn N. and Heng, Chew-Kiat and Hicks, Andrew A. and Hofer, Edith and Huang, Wei and Hutri-Kahonen, Nina and Hwang, Shih-Jen and Ikram, M. Arfan and Indridason, Olafur S. and Ingelsson, Erik and Ising, Marcus and Jaddoe, Vincent W. V. and Jakobsdottir, Johanna and Jonas, Jost B. and Joshi, Peter K. and Josyula, Navya Shilpa and Jung, Bettina and Kahonen, Mika and Kamatani, Yoichiro and Kammerer, Candace M. and Kanai, Masahiro and Kastarinen, Mika and Kerr, Shona M. and Khor, Chiea-Chuen and Kiess, Wieland and Kleber, Marcus E. and Koenig, Wolfgang and Kooner, Jaspal S. and Korner, Antje and Kovacs, Peter and Kraja, Aldi T. and Krajcoviechova, Alena and Kramer, Holly and Kramer, Bernhard K. and Kronenberg, Florian and Kubo, Michiaki and Kuhnel, Brigitte and Kuokkanen, Mikko and Kuusisto, Johanna and La Bianca, Martina and Laakso, Markku and Lange, Leslie A. and Langefeld, Carl D. and Lee, Jeannette Jen-Mai and Lehne, Benjamin and Lehtimaki, Terho and Lieb, Wolfgang and Lim, Su-Chi and Lind, Lars and Lindgren, Cecilia M. and Liu, Jun and Liu, Jianjun and Loeffler, Markus and Loos, Ruth J. F. and Lucae, Susanne and Lukas, Mary Ann and Lyytikainen, Leo-Pekka and Magi, Reedik and Magnusson, Patrik K. E. and Mahajan, Anubha and Martin, Nicholas G. and Martins, Jade and Marz, Winfried and Mascalzoni, Deborah and Matsuda, Koichi and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Metspalu, Andres and Mikaelsdottir, Evgenia K. and Milaneschi, Yuri and Miliku, Kozeta and Mishra, Pashupati P. and Program, V. A. Million Veteran and Mohlke, Karen L. and Mononen, Nina and Montgomery, Grant W. and Mook-Kanamori, Dennis O. and Mychaleckyj, Josyf C. and Nadkarni, Girish N. and Nalls, Mike A. and Nauck, Matthias and Nikus, Kjell and Ning, Boting and Nolte, Ilja M. and Noordam, Raymond and Olafsson, Isleifur and Oldehinkel, Albertine J. and Orho-Melander, Marju and Ouwehand, Willem H. and Padmanabhan, Sandosh and Palmer, Nicholette D. and Palsson, Runolfur and Penninx, Brenda W. J. H. and Perls, Thomas and Perola, Markus and Pirastu, Mario and Pirastu, Nicola and Pistis, Giorgio and Podgornaia, Anna I. and Polasek, Ozren and Ponte, Belen and Porteous, David J. and Poulain, Tanja and Pramstaller, Peter P. and Preuss, Michael H. and Prins, Bram P. and Province, Michael A. and Rabelink, Ton J. and Raffield, Laura M. and Raitakari, Olli T. and Reilly, Dermot F. and Rettig, Rainer and Rheinberger, Myriam and Rice, Kenneth M. and Ridker, Paul M. and Rivadeneira, Fernando and Rizzi, Federica and Roberts, David J. and Robino, Antonietta and Rossing, Peter and Rudan, Igor and Rueedi, Rico and Ruggiero, Daniela and Ryan, Kathleen A. and Saba, Yasaman and Sabanayagam, Charumathi and Salomaa, Veikko and Salvi, Erika and Saum, Kai-Uwe and Schmidt, Helena and Schmidt, Reinhold and Ben Schottker, and Schulz, Christina-Alexandra and Schupf, Nicole and Shaffer, Christian M. and Shi, Yuan and Smith, Albert V. and Smith, Blair H. and Soranzo, Nicole and Spracklen, Cassandra N. and Strauch, Konstantin and Stringham, Heather M. and Stumvoll, Michael and Svensson, Per O. and Szymczak, Silke and Tai, E-Shyong and Tajuddin, Salman M. and Tan, Nicholas Y. Q. and Taylor, Kent D. and Teren, Andrej and Tham, Yih-Chung and Thiery, Joachim and Thio, Chris H. L. and Thomsen, Hauke and Thorleifsson, Gudmar and Toniolo, Daniela and Tonjes, Anke and Tremblay, Johanne and Tzoulaki, Ioanna and Uitterlinden, Andre G. and Vaccargiu, Simona and Van Dam, Rob M. and Van der Harst, Pim and Van Duijn, Cornelia M. and Edward, Digna R. Velez and Verweij, Niek and Vogelezang, Suzanne and Volker, Uwe and Vollenweider, Peter and Waeber, Gerard and Waldenberger, Melanie and Wallentin, Lars and Wang, Ya Xing and Wang, Chaolong and Waterworth, Dawn M. and Bin Wei, Wen and White, Harvey and Whitfield, John B. and Wild, Sarah H. and Wilson, James F. and Wojczynski, Mary K. and Wong, Charlene and Wong, Tien-Yin and Xu, Liang and Yang, Qiong and Yasuda, Masayuki and Yerges-Armstrong, Laura M. and Zhang, Weihua and Zonderman, Alan B. and Rotter, Jerome I. and Bochud, Murielle and Psaty, Bruce M. and Vitart, Veronique and Wilson, James G. and Dehghan, Abbas and Parsa, Afshin and Chasman, Daniel I. and Ho, Kevin and Morris, Andrew P. and Devuyst, Olivier and Akilesh, Shreeram and Pendergrass, Sarah A. and Sim, Xueling and Boger, Carsten A. and Okada, Yukinori and Edwards, Todd L. and Snieder, Harold and Stefansson, Kari and Hung, Adriana M. and Heid, Iris M. and Scholz, Markus and Teumer, Alexander and Kottgen, Anna and Pattaro, Cristian}, title = {A catalog of genetic loci associated with kidney function from analyses of a million individuals}, series = {Nature genetics}, volume = {51}, journal = {Nature genetics}, number = {6}, publisher = {Nature Publ. Group}, address = {New York}, organization = {Lifelines COHort Study}, issn = {1061-4036}, doi = {10.1038/s41588-019-0407-x}, pages = {957 -- +}, year = {2019}, abstract = {Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.}, language = {en} } @inproceedings{TatischeffDeAngelisTavanietal.2018, author = {Tatischeff, V. and De Angelis, A. and Tavani, M. and Grenier, I. and Oberlack, U. and Hanlon, L. and Walter, R. and Argan, A. and von Ballmoos, P. and Bulgarelli, A. and Donnarumma, I. and Hernanz, Margarita and Kuvvetli, I. and Mallamaci, M. and Pearce, M. and Zdziarski, A. and Aboudan, A. and Ajello, M. and Ambrosi, G. and Bernard, D. and Bernardini, E. and Bonvicini, V. and Brogna, A. and Branchesi, M. and Budtz-Jorgensen, C. and Bykov, A. and Campana, R. and Cardillo, M. and Ciprini, S. and Coppi, P. and Cumani, P. and da Silva, R. M. Curado and De Martino, D. and Diehl, R. and Doro, M. and Fioretti, V. and Funk, S. and Ghisellini, G. and Giordano, F. and Grove, J. E. and Hamadache, C. and Hartmann, D. H. and Hayashida, M. and Isern, J. and Kanbach, G. and Kiener, J. and Knodlseder, J. and Labanti, C. and Laurent, P. and Leising, M. and Limousin, O. and Longo, F. and Mannheim, K. and Marisaldi, M. and Martinez, M. and Mazziotta, M. N. and McEnery, J. E. and Mereghetti, S. and Minervini, G. and Moiseev, A. and Morselli, A. and Nakazawa, K. and Orleanski, P. and Paredes, J. M. and Patricelli, B. and Peyre, J. and Piano, G. and Pohl, Martin and Rando, R. and Roncadelli, M. and Tavecchio, F. and Thompson, D. J. and Turolla, R. and Ulyanov, A. and Vacchi, A. and Wu, X. and Zoglauer, A.}, title = {The e-ASTROGAM gamma-ray space observatory for the multimessenger astronomy of the 2030s}, series = {Space Telescopes and Instrumentation 2018: Ultraviolet to Gamma Ray}, volume = {10699}, booktitle = {Space Telescopes and Instrumentation 2018: Ultraviolet to Gamma Ray}, editor = {DenHerder, JWA Nikzad}, publisher = {SPIE - The International Society for Optical Engineering}, address = {Bellingham}, isbn = {978-1-5106-1952-4}, issn = {0277-786X}, doi = {10.1117/12.2315151}, pages = {15}, year = {2018}, abstract = {e-ASTROGAM is a concept for a breakthrough observatory space mission carrying a gamma-ray telescope dedicated to the study of the non-thermal Universe in the photon energy range from 0.15 MeV to 3 GeV. The lower energy limit can be pushed down to energies as low as 30 keV for gamma-ray burst detection with the calorimeter. The mission is based on an advanced space-proven detector technology, with unprecedented sensitivity, angular and energy resolution, combined with remarkable polarimetric capability. Thanks to its performance in the MeV-GeV domain, substantially improving its predecessors, e-ASTROGAM will open a new window on the non-thermal Universe, making pioneering observations of the most powerful Galactic and extragalactic sources, elucidating the nature of their relativistic outflows and their effects on the surroundings. With a line sensitivity in the MeV energy range one to two orders of magnitude better than previous and current generation instruments, e-ASTROGAM will determine the origin of key isotopes fundamental for the understanding of supernova explosion and the chemical evolution of our Galaxy. The mission will be a major player of the multiwavelength, multimessenger time-domain astronomy of the 2030s, and provide unique data of significant interest to a broad astronomical community, complementary to powerful observatories such as LISA, LIGO, Virgo, KAGRA, the Einstein Telescope and the Cosmic Explorer, IceCube-Gen2 and KM3NeT, SKA, ALMA, JWST, E-ELT, LSST, Athena, and the Cherenkov Telescope Array.}, language = {en} } @article{BozzoBhaleraoPradhanetal.2016, author = {Bozzo, Enrico and Bhalerao, V. and Pradhan, Prajal and Tomsick, J. and Romano, Patrizia and Ferrigno, Carlo and Chaty, S. and Oskinova, Lida and Manousakis, A. and Walter, R. and Falanga, M. and Campana, S. and Stella, L. and Ramolla, M. and Chini, R.}, title = {Multi-wavelength observations of IGR J17544-2619 from quiescence to outburst}, series = {Journal of geophysical research : Earth surface}, volume = {596}, journal = {Journal of geophysical research : Earth surface}, publisher = {EDP Sciences}, address = {Les Ulis}, issn = {1432-0746}, doi = {10.1051/0004-6361/201629311}, pages = {12}, year = {2016}, abstract = {In this paper we report on a long multi-wavelength observational campaign of the supergiant fast X-ray transient prototype IGR J17544-2619. A 150 ks-long observation was carried out simultaneously with XMM-Newton and NuSTAR, catching the source in an initial faint X-ray state and then undergoing a bright X-ray outburst lasting approximately 7 ks. We studied the spectral variability during outburst and quiescence by using a thermal and bulk Comptonization model that is typically adopted to describe the X-ray spectral energy distribution of young pulsars in high mass X-ray binaries. Although the statistics of the collected X-ray data were relatively high, we could neither confirm the presence of a cyclotron line in the broad-band spectrum of the source (0.5-40 keV), nor detect any of the previously reported tentative detections of the source spin period. The monitoring carried out with Swift/XRT during the same orbit of the system observed by XMM-Newton and NuSTAR revealed that the source remained in a low emission state for most of the time, in agreement with the known property of all supergiant fast X-ray transients being significantly sub-luminous compared to other supergiant X-ray binaries. Optical and infrared observations were carried out for a total of a few thousand seconds during the quiescence state of the source detected by XMM-Newton and NuSTAR. The measured optical and infrared magnitudes were slightly lower than previous values reported in the literature, but compatible with the known micro-variability of supergiant stars. UV observations obtained with the UVOT telescope on-board Swift did not reveal significant changes in the magnitude of the source in this energy domain compared to previously reported values.}, language = {en} } @article{DeAngelisTatischeffTavanietal.2017, author = {De Angelis, A. and Tatischeff, V. and Tavani, M. and Oberlack, U. and Grenier, I. and Hanloni, L. and Walter, R. and Argan, A. and Von Ballmoos, P. and Bulgarelli, A. and Donnarumma, I. and Hernanz, M. and Kuvvetli, I. and Pearce, M. and Zdziarski, A. and Aboudan, A. and Ajello, M. and Ambrosi, G. and Bernard, D. and Bernardini, E. and Bonvicini, V. and Brogna, A. and Branchesi, M. and Budtz-Jorgensen, C. and Bykov, A. M. and Campana, R. and Cardillo, M. and Coppi, P. and De Martino, D. and Diehl, R. and Doro, M. and Fioretti, V. and Funk, S. and Ghisellini, G. and Grove, E. and Hamadache, C. and Hartmann, D. H. and Hayashida, M. and Isern, J. and Kanbach, G. and Kiener, J. and Knodlseder, J. and Labanti, C. and Laurent, P. and Limousin, O. and Longo, F. and Mannheim, K. and Marisaldi, M. and Martinez, M. and Mazziotta, Mario Nicola and McEnery, J. and Mereghetti, S. and Minervini, G. and Moiseev, A. and Morselli, A. and Nakazawa, K. and Orleanski, P. and Paredes, J. M. and Patricelli, B. and Pevre, J. and Piano, G. and Pohl, Martin and Ramarijaona, H. and Rando, R. and Reichardt, I. and Roncadelli, M. and Silva, R. and Tavecchio, F. and Thompson, D. J. and Turolla, R. and Ulyanov, A. and Vacchi, A. and Wu, X. and Zoglauer, A.}, title = {The e-ASTROGAM mission Exploring the extreme Universe with gamma rays in the MeV - GeV range}, series = {Experimental astronomy : an international journal on astronomical instrumentation and data analysis}, volume = {44}, journal = {Experimental astronomy : an international journal on astronomical instrumentation and data analysis}, publisher = {Springer}, address = {Dordrecht}, organization = {The e-ASTROGAM Collaboration}, issn = {0922-6435}, doi = {10.1007/s10686-017-9533-6}, pages = {25 -- 82}, year = {2017}, abstract = {e-ASTROGAM ('enhanced ASTROGAM') is a breakthrough Observatory space mission, with a detector composed by a Silicon tracker, a calorimeter, and an anticoincidence system, dedicated to the study of the non-thermal Universe in the photon energy range from 0.3 MeV to 3 GeV - the lower energy limit can be pushed to energies as low as 150 keV, albeit with rapidly degrading angular resolution, for the tracker, and to 30 keV for calorimetric detection. The mission is based on an advanced space-proven detector technology, with unprecedented sensitivity, angular and energy resolution, combined with polarimetric capability. Thanks to its performance in the MeV-GeV domain, substantially improving its predecessors, e-ASTROGAM will open a new window on the non-thermal Universe, making pioneering observations of the most powerful Galactic and extragalactic sources, elucidating the nature of their relativistic outflows and their effects on the surroundings. With a line sensitivity in the MeV energy range one to two orders of magnitude better than previous generation instruments, e-ASTROGAM will determine the origin of key isotopes fundamental for the understanding of supernova explosion and the chemical evolution of our Galaxy. The mission will provide unique data of significant interest to a broad astronomical community, complementary to powerful observatories such as LIGO-Virgo-GEO600-KAGRA, SKA, ALMA, E-ELT, TMT, LSST, JWST, Athena, CTA, IceCube, KM3NeT, and the promise of eLISA.}, language = {en} }