@misc{HanackSchloerHolzloehneretal.2016,
  author    = {Hanack, Katja and Schloer, Anja and Holzloehner, Pamela and Listek, Martin and Bauer, Cindy and Butze, Monique and Micheel, Burkhard and Hentschel, Christian and Sowa, Mandy and Roggenbuck, Dirk and Schierack, Peter and Fuener, Jonas and Schliebs, Erik and Goihl, Alexander and Reinhold, Dirk},
  title     = {Camelid nanobodies specific to human pancreatic glycoprotein 2},
  series = {The journal of immunology},
  volume    = {196},
  journal   = {The journal of immunology},
  publisher = {American Assoc. of Immunologists},
  address   = {Bethesda},
  issn      = {0022-1767},
  pages     = {313 -- 328},
  year      = {2016},
  abstract  = {Pancreatic secretory zymogen-granule membrane glycoprotein 2 (GP2) has been identified to be a major autoantigenic target in Crohn's disease patients. It was discussed recently that a long and a short isoform of GP2 exists whereas the short isoform is often detected by GP2-specific autoantibodies. In the outcome of inflammatory bowel diseases, these GP2-specific autoantibodies are discussed as new serological markers for diagnosis and therapeutic monitoring. To investigate this further, camelid nanobodies were generated by phage display and selected against the short isoform of GP2 in order to isolate specific tools for the discrimination of both isoforms. Nanobodies are single domain antibodies derived from camelid heavy chain only antibodies and characterized by a high stability and solubility. The selected candidates were expressed, purified and validated regarding their binding properties in different enzyme-linked immunosorbent assays formats, immunofluorescence, immunohistochemistry and surface plasmon resonance spectroscopy. Four different nanobodies could be selected whereof three recognize the short isoform of GP2 very specifically and one nanobody showed a high binding capacity for both isoforms. The KD values measured for all nanobodies were between 1.3 nM and 2.3 pM indicating highly specific binders suitable for the application as diagnostic tool in inflammatory bowel disease.},
  language  = {en}
}
@article{BauerBoersigPhametal.2022,
  author    = {Bauer, Jonas and B{\"o}rsig, Nicolas and Pham, Van Cam and Hoan, Tran Viet and Nguyen, Ha Thi and Norra, Stefan},
  title     = {Geochemistry and evolution of groundwater resources in the context of salinization and freshening in the southernmost Mekong Delta, Vietnam},
  series = {Journal of Hydrology: Regional Studies},
  volume    = {40},
  journal   = {Journal of Hydrology: Regional Studies},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2214-5818},
  doi       = {10.1016/j.ejrh.2022.101010},
  pages     = {17},
  year      = {2022},
  abstract  = {Study region: Ca Mau Province (CMP), Mekong Delta (MD), Vietnam. Study focus: Groundwater from deep aquifers is the most reliable source of freshwater in the MD but extensive overexploitation in the last decades led to the drop of hydraulic heads and negative environmental impacts. Therefore, a comprehensive groundwater investigation was conducted to evaluate its composition in the context of Quaternary marine transgression and regression cycles, geochemical processes as well as groundwater extraction. New hydrological insights for the region: The abundance of groundwater of Na-HCO3 type and distinct ion ratios, such as Na+/Cl-, indicate extensive freshwater intrusion in an initially saline hydrogeological system, with decreasing intensity from upper Pleistocene to deeper Miocene aquifers, most likely during the last marine regression phase 60-12 ka BP. Deviations from the conservative mixing line between the two endmembers seawater and freshwater are attributed to ion-exchange processes on mineral surfaces, making ion ratios in combination with a customized water type analysis a useful tool to distinguish between salinization and freshening processes. Elevated salinity in some areas is attributed to HCO3- generation by organic matter decomposition in marine sediments rather than to seawater intrusion. Nevertheless, a few randomly distributed locations show strong evidence of recent salinization in an early stage, which may be caused by the downwards migration of saline Holocene groundwater through natural and anthropogenic pathways into deep aquifers.},
  language  = {en}
}
@article{HoanRichterBorsigetal.2022,
  author    = {Hoan, Tran Viet and Richter, Karl-Gerd and Borsig, Nicolas and Bauer, Jonas and Ha, Nguyen Thi and Norra, Stefan},
  title     = {An improved groundwater model framework for aquifer structures of the quaternary-formed sediment body in the southernmost parts of the Mekong Delta, Vietnam},
  series = {Hydrology : open access journal},
  volume    = {9},
  journal   = {Hydrology : open access journal},
  number    = {4},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2306-5338},
  doi       = {10.3390/hydrology9040061},
  pages     = {20},
  year      = {2022},
  abstract  = {The Ca Mau peninsula (CMP) is a key economic region in southern Vietnam. In recent decades, the high demand for water has increased the exploitation of groundwater, thus lowering the groundwater level and leading to risks of degradation, depletion, and land subsidence, as well as salinity intrusion in the groundwater of the whole Mekong Delta region. By using a finite element groundwater model with boundary expansion to the sea, we updated the latest data on hydrogeological profiles, groundwater levels, and exploitation. The basic model setup covers seven aquifers and seven aquitards. It is determined that the inflow along the coastline to the mainland is 39\% of the total inflow. The exploitation of the study area in 2019 was 567,364 m(3)/day. The most exploited aquifers are the upper-middle Pleistocene (qp(2-3)) and the middle Pliocene (n(2)(2)), accounting for 63.7\% and 24.6\%, respectively; the least exploited aquifers are the upper Pleistocene and the upper Miocene, accounting for 0.35\% and 0.02\%, respectively. In the deeper aquifers, qp(2-3) and n(2)(2), the change in storage is negative due to the high exploitation rate, leading to a decline in the reserves of these aquifers. These groundwater model results are the calculations of groundwater reserves from the coast to the mainland in the entire system of aquifers in the CMP. This makes groundwater decision managers, stakeholders, and others more efficient in sustainable water resources planning in the CMP and Mekong Delta (MKD).},
  language  = {en}
}