@misc{FrielerLevermannElliottetal.2015, author = {Frieler, Katja and Levermann, Anders and Elliott, J. and Heinke, J. and Arneth, A. and Bierkens, M. F. P. and Ciais, Philippe and Clark, D. B. and Deryng, D. and Doell, P. and Falloon, P. and Fekete, B. and Folberth, Christian and Friend, A. D. and Gellhorn, C. and Gosling, S. N. and Haddeland, I. and Khabarov, N. and Lomas, M. and Masaki, Y. and Nishina, K. and Neumann, K. and Oki, T. and Pavlick, R. and Ruane, A. C. and Schmid, E. and Schmitz, C. and Stacke, T. and Stehfest, E. and Tang, Q. and Wisser, D. and Huber, V. and Piontek, Franziska and Warszawski, L. and Schewe, Jacob and Lotze-Campen, Hermann and Schellnhuber, Hans Joachim}, title = {A framework for the cross-sectoral integration of multi-model impact projections}, series = {Earth system dynamics}, journal = {Earth system dynamics}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-407968}, pages = {14}, year = {2015}, abstract = {Climate change and its impacts already pose considerable challenges for societies that will further increase with global warming (IPCC, 2014a, b). Uncertainties of the climatic response to greenhouse gas emissions include the potential passing of large-scale tipping points (e.g. Lenton et al., 2008; Levermann et al., 2012; Schellnhuber, 2010) and changes in extreme meteorological events (Field et al., 2012) with complex impacts on societies (Hallegatte et al., 2013). Thus climate change mitigation is considered a necessary societal response for avoiding uncontrollable impacts (Conference of the Parties, 2010). On the other hand, large-scale climate change mitigation itself implies fundamental changes in, for example, the global energy system. The associated challenges come on top of others that derive from equally important ethical imperatives like the fulfilment of increasing food demand that may draw on the same resources. For example, ensuring food security for a growing population may require an expansion of cropland, thereby reducing natural carbon sinks or the area available for bio-energy production. So far, available studies addressing this problem have relied on individual impact models, ignoring uncertainty in crop model and biome model projections. Here, we propose a probabilistic decision framework that allows for an evaluation of agricultural management and mitigation options in a multi-impact-model setting. Based on simulations generated within the Inter-Sectoral Impact Model Intercomparison Project (ISI-MIP), we outline how cross-sectorally consistent multi-model impact simulations could be used to generate the information required for robust decision making. Using an illustrative future land use pattern, we discuss the trade-off between potential gains in crop production and associated losses in natural carbon sinks in the new multiple crop-and biome-model setting. In addition, crop and water model simulations are combined to explore irrigation increases as one possible measure of agricultural intensification that could limit the expansion of cropland required in response to climate change and growing food demand. This example shows that current impact model uncertainties pose an important challenge to long-term mitigation planning and must not be ignored in long-term strategic decision making.}, language = {en} } @article{FrielerLevermannElliottetal.2015, author = {Frieler, Katja and Levermann, Anders and Elliott, J. and Heinke, Jens and Arneth, A. and Bierkens, M. F. P. and Ciais, Philippe and Clark, D. B. and Deryng, D. and Doell, P. and Falloon, P. and Fekete, B. and Folberth, Christian and Friend, A. D. and Gellhorn, C. and Gosling, S. N. and Haddeland, I. and Khabarov, N. and Lomas, M. and Masaki, Y. and Nishina, K. and Neumann, K. and Oki, T. and Pavlick, R. and Ruane, A. C. and Schmid, E. and Schmitz, C. and Stacke, T. and Stehfest, E. and Tang, Q. and Wisser, D. and Huber, Veronika and Piontek, Franziska and Warszawski, Lila and Schewe, Jacob and Lotze-Campen, Hermann and Schellnhuber, Hans Joachim}, title = {A framework for the cross-sectoral integration of multi-model impact projections}, series = {Earth system dynamics}, volume = {6}, journal = {Earth system dynamics}, number = {2}, publisher = {Copernicus}, address = {G{\"o}ttingen}, issn = {2190-4979}, doi = {10.5194/esd-6-447-2015}, pages = {447 -- 460}, year = {2015}, abstract = {Climate change and its impacts already pose considerable challenges for societies that will further increase with global warming (IPCC, 2014a, b). Uncertainties of the climatic response to greenhouse gas emissions include the potential passing of large-scale tipping points (e.g. Lenton et al., 2008; Levermann et al., 2012; Schellnhuber, 2010) and changes in extreme meteorological events (Field et al., 2012) with complex impacts on societies (Hallegatte et al., 2013). Thus climate change mitigation is considered a necessary societal response for avoiding uncontrollable impacts (Conference of the Parties, 2010). On the other hand, large-scale climate change mitigation itself implies fundamental changes in, for example, the global energy system. The associated challenges come on top of others that derive from equally important ethical imperatives like the fulfilment of increasing food demand that may draw on the same resources. For example, ensuring food security for a growing population may require an expansion of cropland, thereby reducing natural carbon sinks or the area available for bio-energy production. So far, available studies addressing this problem have relied on individual impact models, ignoring uncertainty in crop model and biome model projections. Here, we propose a probabilistic decision framework that allows for an evaluation of agricultural management and mitigation options in a multi-impact-model setting. Based on simulations generated within the Inter-Sectoral Impact Model Intercomparison Project (ISI-MIP), we outline how cross-sectorally consistent multi-model impact simulations could be used to generate the information required for robust decision making. Using an illustrative future land use pattern, we discuss the trade-off between potential gains in crop production and associated losses in natural carbon sinks in the new multiple crop-and biome-model setting. In addition, crop and water model simulations are combined to explore irrigation increases as one possible measure of agricultural intensification that could limit the expansion of cropland required in response to climate change and growing food demand. This example shows that current impact model uncertainties pose an important challenge to long-term mitigation planning and must not be ignored in long-term strategic decision making.}, language = {en} } @article{ChristensenLentzMortensenetal.2005, author = {Christensen, B. J. and Lentz, R. and Mortensen, D. T. and Neumann, G. R. and Werwatz, A.}, title = {On-the-job search and the wage distribution}, issn = {0734-306X}, year = {2005}, abstract = {The article structually estimates an on-the-job search model of job separations. Given each employer pays observably equivalent workers the same but wages are dispersed across employers, an employer's separation flow is the sum of an exogenous outflow unrelated to the wage and a job-to-job flow that decreases with the employer's wage. Using data from the Danish Integrated Database for Labour Market Research, the empirical results imply, as predicted by theory, that search effort declines with the wage. Furthermore, the estimates explain the employment effect, defined as the horizontal difference between the distribution of wages earned and the wage offer distribution}, language = {en} } @article{SchellerBierNeumann1994, author = {Scheller, Frieder W. and Bier, Frank Fabian and Neumann, B.}, title = {Bioindikation in aquatischen {\"O}kosystemen : Bioindikation in limnischen und k{\"u}stennahen {\"O}kosystemen ; Grundlagen, Verfahren und Methoden}, publisher = {Fischer}, address = {Jena}, pages = {S. 380 - 386}, year = {1994}, language = {de} } @article{WelzelKossmehlEngelmannetal.1997, author = {Welzel, H.-P. and Kossmehl, G. and Engelmann, G. and Neumann, B. and Wollenberger, Ursula and Scheller, Frieder W.}, title = {Electrochemical polymerization of functionalized thiohene derivatives for immobilization of proteins}, year = {1997}, language = {en} } @article{WollenbergerNeumann1997, author = {Wollenberger, Ursula and Neumann, B.}, title = {Quinoprotein glucose dehydrogenase modified carbon paste electrode for detection of phenolic compounds}, year = {1997}, language = {en} } @article{RiedelBeyersdorfRadeckNeumannetal.1995, author = {Riedel, K. and Beyersdorf-Radeck, Baerbel and Neumann, B. and Scheller, Frieder W. and Schmid, Rolf D.}, title = {Microbial sensors for determination of aromatics and their chloro derivatives. Part III: Determination of chlorinated phenols using a biosensor containing Trichosporon beigelii (cutaneum)}, year = {1995}, language = {en} } @article{WollenbergerNeumannScheller1998, author = {Wollenberger, Ursula and Neumann, B. and Scheller, Frieder W.}, title = {Development of a biomimetic alkane sensor f}, year = {1998}, language = {en} } @article{WollenbergerNeumannRiedeletal.1994, author = {Wollenberger, Ursula and Neumann, B. and Riedel, K. and Scheller, Frieder W.}, title = {Enzyme and microbial sensors for phosphate, phenols, pesticides and peroxides}, year = {1994}, language = {en} } @article{WelzelKossmehlEngelmannetal.1996, author = {Welzel, H.-P. and Kossmehl, G. and Engelmann, G. and Neumann, B. and Wollenberger, Ursula and Scheller, Frieder W. and Schr{\"o}der, W.}, title = {Reactive groups on polymer covered electrodes, 4. Lactate-oxidase-biosensor based on electrodes modifies by polyphiophene}, year = {1996}, language = {en} } @article{WollenbergerNeumannScheller1993, author = {Wollenberger, Ursula and Neumann, B. and Scheller, Frieder W.}, title = {Enzyme and microbial sensors for environmental Monitoring}, year = {1993}, language = {en} } @article{GereckeEdlichGiulbudagianetal.2017, author = {Gerecke, Christian and Edlich, Alexander and Giulbudagian, Michael and Schumacher, Fabian and Zhang, Nan and Said, Andre and Yealland, Guy and Lohan, Silke B. and Neumann, Falko and Meinke, Martina C. and Ma, Nan and Calderon, Marcelo and Hedtrich, Sarah and Schaefer-Korting, Monika and Kleuser, Burkhard}, title = {Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes}, series = {Nanotoxicology}, volume = {11}, journal = {Nanotoxicology}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1743-5390}, doi = {10.1080/17435390.2017.1292371}, pages = {267 -- 277}, year = {2017}, abstract = {Novel nanogels that possess the capacity to change their physico-chemical properties in response to external stimuli are promising drug-delivery candidates for the treatment of severe skin diseases. As thermoresponsive nanogels (tNGs) are capable of enhancing penetration through biological barriers such as the stratum corneum and are taken up by keratinocytes of human skin, potential adverse consequences of their exposure must be elucidated. In this study, tNGs were synthesized from dendritic polyglycerol (dPG) and two thermoresponsive polymers. tNG_dPG_tPG are the combination of dPG with poly(glycidyl methyl ether-co-ethyl glycidyl ether) (p(GME-co-EGE)) and tNG_dPG_pNIPAM the one with poly(N-isopropylacrylamide) (pNIPAM). Both thermoresponsive nanogels are able to incorporate high amounts of dexamethasone and tacrolimus, drugs used in the treatment of severe skin diseases. Cellular uptake, intracellular localization and the toxicological properties of the tNGs were comprehensively characterized in primary normal human keratinocytes (NHK) and in spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin (HaCaT). Laser scanning confocal microscopy revealed fluorescently labeled tNGs entered into the cells and localized predominantly within lysosomal compartments. MTT assay, comet assay and carboxy-H2DCFDA assay, demonstrated neither cytotoxic or genotoxic effects, nor any induction of reactive oxygen species of the tNGs in keratinocytes. In addition, both tNGs were devoid of eye irritation potential as shown by bovine corneal opacity and permeability (BCOP) test and red blood cell (RBC) hemolysis assay. Therefore, our study provides evidence that tNGs are locally well tolerated and underlines their potential for cutaneous drug delivery.}, language = {en} } @misc{GereckeEdlichGiulbudagianetal.2017, author = {Gerecke, Christian and Edlich, Alexander and Giulbudagian, Michael and Schumacher, Fabian and Zhang, Nan and Said, Andre and Yealland, Guy and Lohan, Silke B. and Neumann, Falko and Meinke, Martina C. and Ma, Nan and Calder{\´o}n, Marcelo and Hedtrich, Sarah and Sch{\"a}fer-Korting, Monika and Kleuser, Burkhard}, title = {Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-395325}, pages = {11}, year = {2017}, abstract = {Novel nanogels that possess the capacity to change their physico-chemical properties in response to external stimuli are promising drug-delivery candidates for the treatment of severe skin diseases. As thermoresponsive nanogels (tNGs) are capable of enhancing penetration through biological barriers such as the stratum corneum and are taken up by keratinocytes of human skin, potential adverse consequences of their exposure must be elucidated. In this study, tNGs were synthesized from dendritic polyglycerol (dPG) and two thermoresponsive polymers. tNG_dPG_tPG are the combination of dPG with poly(glycidyl methyl ether-co-ethyl glycidyl ether) (p(GME-co-EGE)) and tNG_dPG_pNIPAM the one with poly(N-isopropylacrylamide) (pNIPAM). Both thermoresponsive nanogels are able to incorporate high amounts of dexamethasone and tacrolimus, drugs used in the treatment of severe skin diseases. Cellular uptake, intracellular localization and the toxicological properties of the tNGs were comprehensively characterized in primary normal human keratinocytes (NHK) and in spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin (HaCaT). Laser scanning confocal microscopy revealed fluorescently labeled tNGs entered into the cells and localized predominantly within lysosomal compartments. MTT assay, comet assay and carboxy-H2DCFDA assay, demonstrated neither cytotoxic or genotoxic effects, nor any induction of reactive oxygen species of the tNGs in keratinocytes. In addition, both tNGs were devoid of eye irritation potential as shown by bovine corneal opacity and permeability (BCOP) test and red blood cell (RBC) hemolysis assay. Therefore, our study provides evidence that tNGs are locally well tolerated and underlines their potential for cutaneous drug delivery.}, language = {en} } @article{GrottKnollenbergHammetal.2019, author = {Grott, Matthias and Knollenberg, J. and Hamm, M. and Ogawa, K. and Jaumann, R. and Otto, Katharina Alexandra and Delbo, M. and Michel, Patrick and Biele, J. and Neumann, Wladimir and Knapmeyer, Martin and K{\"u}hrt, E. and Senshu, H. and Okada, T. and Helbert, Jorn and Maturilli, A. and M{\"u}ller, N. and Hagermann, A. and Sakatani, Naoya and Tanaka, S. and Arai, T. and Mottola, Stefano and Tachibana, Shogo and Pelivan, Ivanka and Drube, Line and Vincent, J-B and Yano, Hajime and Pilorget, C. and Matz, K. D. and Schmitz, N. and Koncz, A. and Schr{\"o}der, Stefan E. and Trauthan, F. and Schlotterer, Markus and Krause, C. and Ho, T-M and Moussi-Soffys, A.}, title = {Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu}, series = {Nature astronomy}, volume = {3}, journal = {Nature astronomy}, number = {11}, publisher = {Nature Publishing Group}, address = {London}, issn = {2397-3366}, doi = {10.1038/s41550-019-0832-x}, pages = {971 -- 976}, year = {2019}, abstract = {C-type asteroids are among the most pristine objects in the Solar System, but little is known about their interior structure and surface properties. Telescopic thermal infrared observations have so far been interpreted in terms of a regolith-covered surface with low thermal conductivity and particle sizes in the centimetre range. This includes observations of C-type asteroid (162173) Ryugu1,2,3. However, on arrival of the Hayabusa2 spacecraft at Ryugu, a regolith cover of sand- to pebble-sized particles was found to be absent4,5 (R.J. et al., manuscript in preparation). Rather, the surface is largely covered by cobbles and boulders, seemingly incompatible with the remote-sensing infrared observations. Here we report on in situ thermal infrared observations of a boulder on the C-type asteroid Ryugu. We found that the boulder's thermal inertia was much lower than anticipated based on laboratory measurements of meteorites, and that a surface covered by such low-conductivity boulders would be consistent with remote-sensing observations. Our results furthermore indicate high boulder porosities as well as a low tensile strength in the few hundred kilopascal range. The predicted low tensile strength confirms the suspected observational bias6 in our meteorite collections, as such asteroidal material would be too frail to survive atmospheric entry7}, language = {en} } @article{GrottKnollenbergHammetal.2019, author = {Grott, Matthias and Knollenberg, J. and Hamm, M. and Ogawa, K. and Jaumann, R. and Otto, Katharina Alexandra and Delbo, M. and Michel, P. and Biele, J. and Neumann, W. and Knapmeyer, M. and Kuehrt, E. and Senshu, H. and Okada, T. and Helbert, J. and Maturilli, A. and M{\"u}ller, N. and Hagermann, A. and Sakatani, N. and Tanaka, S. and Arai, T. and Mottola, S. and Tachibana, S. and Pelivan, Ivanka and Drube, L. and Vincent, J-B and Yano, H. and Pilorget, C. and Matz, K. D. and Schmitz, N. and Koncz, A. and Schr{\"o}der, S. E. and Trauthan, F. and Schlotterer, M. and Krause, C. and Ho, T-M and Moussi-Soffys, A.}, title = {Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu}, series = {Nature astronomy}, volume = {3}, journal = {Nature astronomy}, number = {11}, publisher = {Nature Publishing Group}, address = {London}, issn = {2397-3366}, doi = {10.1038/s41550-019-0832-x}, pages = {971 -- 976}, year = {2019}, abstract = {C-type asteroids are among the most pristine objects in the Solar System, but little is known about their interior structure and surface properties. Telescopic thermal infrared observations have so far been interpreted in terms of a regolith-covered surface with low thermal conductivity and particle sizes in the centimetre range. This includes observations of C-type asteroid (162173) Ryugu1,2,3. However, on arrival of the Hayabusa2 spacecraft at Ryugu, a regolith cover of sand- to pebble-sized particles was found to be absent4,5 (R.J. et al., manuscript in preparation). Rather, the surface is largely covered by cobbles and boulders, seemingly incompatible with the remote-sensing infrared observations. Here we report on in situ thermal infrared observations of a boulder on the C-type asteroid Ryugu. We found that the boulder's thermal inertia was much lower than anticipated based on laboratory measurements of meteorites, and that a surface covered by such low-conductivity boulders would be consistent with remote-sensing observations. Our results furthermore indicate high boulder porosities as well as a low tensile strength in the few hundred kilopascal range. The predicted low tensile strength confirms the suspected observational bias6 in our meteorite collections, as such asteroidal material would be too frail to survive atmospheric entry7.}, language = {en} }