@article{SchuchStubbsMeyeretal.2019, author = {Schuch, Felipe B. and Stubbs, Brendon and Meyer, Jacob and Heissel, Andreas and Zech, Philipp and Vancampfort, Davy and Rosenbaum, Simon and Deenik, Jeroen and Firth, Joseph and Ward, Philip B. and Carvalho, Andre F. and Hiles, Sarah A.}, title = {Physical activity protects from incident anxiety: A meta-analysis of prospective cohort studies}, series = {Depression and anxiety}, volume = {36}, journal = {Depression and anxiety}, number = {9}, publisher = {Wiley}, address = {Hoboken}, issn = {1091-4269}, doi = {10.1002/da.22915}, pages = {846 -- 858}, year = {2019}, abstract = {Background Prospective cohorts have suggested that physical activity (PA) can decrease the risk of incident anxiety. However, no meta-analysis has been conducted. Aims To examine the prospective relationship between PA and incident anxiety and explore potential moderators. Methods Searches were conducted on major databases from inception to October 10, 2018 for prospective studies (at least 1 year of follow-up) that calculated the odds ratio (OR) of incident anxiety in people with high PA against people with low PA. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was conducted and heterogeneity was explored using subgroup and meta-regression analysis. Results Across 14 cohorts of 13 unique prospective studies (N = 75,831, median males = 50.1\%) followed for 357,424 person-years, people with high self-reported PA (versus low PA) were at reduced odds of developing anxiety (adjusted odds ratio [AOR] = 0.74; 95\% confidence level [95\% CI] = 0.62, 0.88; crude OR = 0.80; 95\% CI = 0.69, 0.92). High self-reported PA was protective against the emergence of agoraphobia (AOR = 0.42; 95\% CI = 0.18, 0.98) and posttraumatic stress disorder (AOR = 0.57; 95\% CI = 0.39, 0.85). The protective effects for anxiety were evident in Asia (AOR = 0.31; 95\% CI = 0.10, 0.96) and Europe (AOR = 0.82; 95\% CI = 0.69, 0.97); for children/adolescents (AOR = 0.52; 95\% CI = 0.29, 0.90) and adults (AOR = 0.81; 95\% CI = 0.69, 0.95). Results remained robust when adjusting for confounding factors. Overall study quality was moderate to high (mean NOS = 6.7 out of 9). Conclusion Evidence supports the notion that self-reported PA can confer protection against the emergence of anxiety regardless of demographic factors. In particular, higher PA levels protects from agoraphobia and posttraumatic disorder.}, language = {en} } @article{YenesewMushibeIndulietal.2005, author = {Yenesew, Abiy and Mushibe, E. K. and Induli, M. and Derese, Solomon and Midiwo, Jacob O. and Kabaru, Jacques M. and Heydenreich, Matthias and Koch, Andreas and Peter, Martin G.}, title = {7a-O-methyldeguelol, a modified rotenoid with an open ring-C, from the roots of Derris trifoloata}, issn = {0031-9422}, year = {2005}, abstract = {From the acetone extract of the roots of Derris trifoliata an isollavonoid derivative, named 7a-O- methyldeguelol, a modified rotenoid with an open ring-C, representing a new sub-class of isollavonoids (the sub-class is here named as rotenoloid), was isolated and characterised. In addition, the known rotenoids, rotenone, deguelin and alpha-toxicarol, were identified. The structures were determined on the basis of spectroscopic evidence. Rotenone and deguelin were identified as the larvicidal principles of the acetone extract of the roots of Derris trifoliata. (c) 2005 Elsevier Ltd. All rights reserved}, language = {en} } @article{IzraylitHommesSchattmannNeffeetal.2020, author = {Izraylit, Victor and Hommes-Schattmann, Paul Jacob and Neffe, Axel T. and Gould, Oliver E. C. and Lendlein, Andreas}, title = {Alkynyl-functionalized chain-extended PCL for coupling to biological molecules}, series = {European polymer journal}, volume = {136}, journal = {European polymer journal}, publisher = {Elsevier}, address = {Oxford}, issn = {0014-3057}, doi = {10.1016/j.eurpolymj.2020.109908}, pages = {11}, year = {2020}, abstract = {Chemical functionalization of poly(epsilon-caprolactone) (PCL) enables a molecular integration of additional function. Here, we report an approach to incorporate reactive alkynyl side-groups by synthesizing a chain-extended PCL, where the reactive site is introduced through the covalently functionalizable chain extender 3 (prop-2-yn-1-yloxy)propane-1,2-diol (YPD). Chain-extended PCL with M-w of 101 to 385 kg.mol(-1) were successfully synthesized in a one-pot reaction from PCL-diols with various molar masses, L-lysine ethyl ester diisocyanate (LDI) or trimethyl(hexamethylene)diisocyanate (TMDI), and YPD, in which the density of functionalizable groups and spacing between them can be controlled by the composition of the polymer. The employed diisocyanate compounds and YPD possess an asymmetric structure and form a non-crystallizable segment leaving the PCL crystallites to dominate the material's mechanical properties. The mixed glass transition temperature T-g = - 60 to - 46 degrees C of the PCL/polyurethane amorphous phase maintains the synthesized materials in a highly elastic state at ambient and physiological conditions. Reaction conditions for covalent attachment in copper(I)-catalyzed azide-alkyne-cycloaddition reactions (CuAAC) in solution were optimized in a series of model reactions between the alkyne moieties of the chain-extended PCL and benzyl azide, reaching conversions over 95\% of the alkyne moieties and with yields of up to 94\% for the purified functionalized PCL. This methodology was applied for reaction with the azide-functionalized cell adhesion peptide GRGDS. The required modification of the peptide provides selectivity in the coupling reactions. The obtained results suggest that YPD could potentially be employed as versatile molecular unit for the creation of a variety of functionalizable polyesters as well as polyurethanes and polycarbonates offering efficient and selective click-reactions.}, language = {en} } @article{PingelMulchAlonsoetal.2016, author = {Pingel, Heiko and Mulch, Andreas and Alonso, Ricardo N. and Cottle, John and Hynek, Scott A. and Poletti, Jacob and Rohrmann, Alexander and Schmitt, Axel K. and Stockli, Daniel F. and Strecker, Manfred}, title = {Surface uplift and convective rainfall along the southern Central Andes (Angastaco Basin, NW Argentina)}, series = {Earth \& planetary science letters}, volume = {440}, journal = {Earth \& planetary science letters}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0012-821X}, doi = {10.1016/j.epsl.2016.02.009}, pages = {33 -- 42}, year = {2016}, abstract = {Stable-isotopic and sedimentary records from the orogenic Puna Plateau of NW Argentina and adjacent intermontane basins to the east furnish a unique late Cenozoic record of range uplift and ensuing paleoenvironmental change in the south-central Andes. Today, focused precipitation in this region occurs along the eastern, windward flanks of the Eastern Cordillera and Sierras Pampeanas ranges, while the orogen interior constitutes high-elevation regions with increasingly arid conditions in a westward direction. As in many mountain belts, such hydrologic and topographic gradients are commonly mirrored by a systematic relationship between the oxygen and hydrogen stable isotope ratios of meteoric water and elevation. The glass fraction of isotopically datable volcanic ash intercalated in sedimentary sequences constitutes an environmental proxy that retains a signal of the hydrogen-isotopic composition of ancient precipitation. This isotopic composition thus helps to elucidate the combined climatic and tectonic processes associated with topographic growth, which ultimately controls the spatial patterns of precipitation in mountain belts. However, between 25.5 and 27 degrees S present-day river-based hydrogen isotope lapse rates are very low, possibly due to deep-convective seasonal storms that dominate runoff. If not accounted for, the effects of such conditions on moisture availability in the past may lead to misinterpretations of proxy-records of rainfall. Here, we present hydrogen-isotope data of volcanic glass (delta Dg), extracted from 34 volcanic ash layers in different sedimentary basins of the Eastern Cordillera and the Sierras Pampeanas. Combined with previously published delta Dg records and our refined U-Pb and (U-Th)/He zircon geochronology on 17 tuff samples, we demonstrate hydrogen-isotope variations associated with paleoenvironmental change in the Angastaco Basin, which evolved from a contiguous foreland to a fault-bounded intermontane basin during the late Mio-Pliocene. We unravel the environmental impact of Mio-Pliocene topographic growth and associated orographic effects on long-term hydrogen-isotope records of rainfall in the south-central Andes, and potentially identify temporal variations in regional isotopic lapse rates that may also apply to other regions with similar topographic boundary conditions. (C) 2016 Elsevier B.V. All rights reserved.}, language = {en} } @article{TiegsCostelloIskenetal.2019, author = {Tiegs, Scott D. and Costello, David M. and Isken, Mark W. and Woodward, Guy and McIntyre, Peter B. and Gessner, Mark O. and Chauvet, Eric and Griffiths, Natalie A. and Flecker, Alex S. and Acuna, Vicenc and Albarino, Ricardo and Allen, Daniel C. and Alonso, Cecilia and Andino, Patricio and Arango, Clay and Aroviita, Jukka and Barbosa, Marcus V. M. and Barmuta, Leon A. and Baxter, Colden V. and Bell, Thomas D. C. and Bellinger, Brent and Boyero, Luz and Brown, Lee E. and Bruder, Andreas and Bruesewitz, Denise A. and Burdon, Francis J. and Callisto, Marcos and Canhoto, Cristina and Capps, Krista A. and Castillo, Maria M. and Clapcott, Joanne and Colas, Fanny and Colon-Gaud, Checo and Cornut, Julien and Crespo-Perez, Veronica and Cross, Wyatt F. and Culp, Joseph M. and Danger, Michael and Dangles, Olivier and de Eyto, Elvira and Derry, Alison M. and Diaz Villanueva, Veronica and Douglas, Michael M. and Elosegi, Arturo and Encalada, Andrea C. and Entrekin, Sally and Espinosa, Rodrigo and Ethaiya, Diana and Ferreira, Veronica and Ferriol, Carmen and Flanagan, Kyla M. and Fleituch, Tadeusz and Shah, Jennifer J. Follstad and Frainer, Andre and Friberg, Nikolai and Frost, Paul C. and Garcia, Erica A. and Lago, Liliana Garcia and Garcia Soto, Pavel Ernesto and Ghate, Sudeep and Giling, Darren P. and Gilmer, Alan and Goncalves, Jose Francisco and Gonzales, Rosario Karina and Graca, Manuel A. S. and Grace, Mike and Grossart, Hans-Peter and Guerold, Francois and Gulis, Vlad and Hepp, Luiz U. and Higgins, Scott and Hishi, Takuo and Huddart, Joseph and Hudson, John and Imberger, Samantha and Iniguez-Armijos, Carlos and Iwata, Tomoya and Janetski, David J. and Jennings, Eleanor and Kirkwood, Andrea E. and Koning, Aaron A. and Kosten, Sarian and Kuehn, Kevin A. and Laudon, Hjalmar and Leavitt, Peter R. and Lemes da Silva, Aurea L. and Leroux, Shawn J. and Leroy, Carri J. and Lisi, Peter J. and MacKenzie, Richard and Marcarelli, Amy M. and Masese, Frank O. and Mckie, Brendan G. and Oliveira Medeiros, Adriana and Meissner, Kristian and Milisa, Marko and Mishra, Shailendra and Miyake, Yo and Moerke, Ashley and Mombrikotb, Shorok and Mooney, Rob and Moulton, Tim and Muotka, Timo and Negishi, Junjiro N. and Neres-Lima, Vinicius and Nieminen, Mika L. and Nimptsch, Jorge and Ondruch, Jakub and Paavola, Riku and Pardo, Isabel and Patrick, Christopher J. and Peeters, Edwin T. H. M. and Pozo, Jesus and Pringle, Catherine and Prussian, Aaron and Quenta, Estefania and Quesada, Antonio and Reid, Brian and Richardson, John S. and Rigosi, Anna and Rincon, Jose and Risnoveanu, Geta and Robinson, Christopher T. and Rodriguez-Gallego, Lorena and Royer, Todd V. and Rusak, James A. and Santamans, Anna C. and Selmeczy, Geza B. and Simiyu, Gelas and Skuja, Agnija and Smykla, Jerzy and Sridhar, Kandikere R. and Sponseller, Ryan and Stoler, Aaron and Swan, Christopher M. and Szlag, David and Teixeira-de Mello, Franco and Tonkin, Jonathan D. and Uusheimo, Sari and Veach, Allison M. and Vilbaste, Sirje and Vought, Lena B. M. and Wang, Chiao-Ping and Webster, Jackson R. and Wilson, Paul B. and Woelfl, Stefan and Xenopoulos, Marguerite A. and Yates, Adam G. and Yoshimura, Chihiro and Yule, Catherine M. and Zhang, Yixin X. and Zwart, Jacob A.}, title = {Global patterns and drivers of ecosystem functioning in rivers and riparian zones}, series = {Science Advances}, volume = {5}, journal = {Science Advances}, number = {1}, publisher = {American Assoc. for the Advancement of Science}, address = {Washington}, issn = {2375-2548}, doi = {10.1126/sciadv.aav0486}, pages = {8}, year = {2019}, abstract = {River ecosystems receive and process vast quantities of terrestrial organic carbon, the fate of which depends strongly on microbial activity. Variation in and controls of processing rates, however, are poorly characterized at the global scale. In response, we used a peer-sourced research network and a highly standardized carbon processing assay to conduct a global-scale field experiment in greater than 1000 river and riparian sites. We found that Earth's biomes have distinct carbon processing signatures. Slow processing is evident across latitudes, whereas rapid rates are restricted to lower latitudes. Both the mean rate and variability decline with latitude, suggesting temperature constraints toward the poles and greater roles for other environmental drivers (e.g., nutrient loading) toward the equator. These results and data set the stage for unprecedented "next-generation biomonitoring" by establishing baselines to help quantify environmental impacts to the functioning of ecosystems at a global scale.}, language = {en} } @misc{HellmannRettweilerKrameretal.2007, author = {Hellmann, Uwe and Rettweiler, Udo and Kramer, Annette and Zehe, Erwin and Jacob, Andreas and Hafner, Johann Evangelist and Tronicke, Jens and M{\"u}hle, Ralf-Udo and Klauss, Susanne and Dietrich, Larissa and Richter, Norbert and Schweigl, Kerstin}, title = {Portal = Ressource Wasser: Mehr als ein Elixier des Lebens}, number = {04-05/2007}, organization = {Universit{\"a}t Potsdam, Referat f{\"u}r Presse- und {\"O}ffentlichkeitsarbeit}, issn = {1618-6893}, doi = {10.25932/publishup-44005}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-440051}, pages = {43}, year = {2007}, abstract = {Aus dem Inhalt: - Ressource Wasser: Mehr als ein Elixier des Lebens - Dorniges hinter Glas - Die Profstars 2007 - Technik gegen unerw{\"u}nschte Mith{\"o}rer entwickelt}, language = {de} } @article{TschornSchulzeFoerstneretal.2022, author = {Tschorn, Mira and Schulze, Susanne and F{\"o}rstner, Bernd Rainer and Holmberg, Christine and Spallek, Jacob and Heinz, Andreas and Rapp, Michael A.}, title = {Predictors and prevalence of hazardous alcohol use in middle-late to late adulthood in Europe}, series = {Aging \& mental health}, volume = {27}, journal = {Aging \& mental health}, number = {5}, publisher = {Routledge, Taylor \& Francis Group}, address = {Abingdon}, issn = {1360-7863}, doi = {10.1080/13607863.2022.2076208}, pages = {1001 -- 1010}, year = {2022}, abstract = {Objectives: Even low to moderate levels of alcohol consumption can have detrimental health consequences, especially in older adults (OA). Although many studies report an increase in the proportion of drinkers among OA, there are regional variations. Therefore, we examined alcohol consumption and the prevalence of hazardous alcohol use (HAU) among men and women aged 50+ years in four European regions and investigated predictors of HAU. Methods: We analyzed data of N = 35,042 participants of the European SHARE study. We investigated differences in alcohol consumption (units last week) according to gender, age and EU-region using ANOVAs. Furthermore, logistic regression models were used to examine the effect of income, education, marital status, history of a low-quality parent-child relationship and smoking on HAU, also stratified for gender and EU-region. HAU was operationalized as binge drinking or risky drinking (<12.5 units of 10 ml alcohol/week). Results: Overall, past week alcohol consumption was 5.0 units (+/- 7.8), prevalence of HAU was 25.4\% within our sample of European adults aged 50+ years. Male gender, younger age and living in Western Europe were linked to both higher alcohol consumption and higher risks of HAU. Income, education, smoking, a low-quality parent-child relationship, living in Northern and especially Eastern Europe were positively associated with HAU. Stratified analyses revealed differences by region and gender. Conclusions: HAU was highly prevalent within this European sample of OA. Alcohol consumption and determinants of HAU differed between EU-regions, hinting to a necessity of risk-stratified population-level strategies to prevent HAU and subsequent alcohol use disorders.}, language = {en} }