@misc{DoegeHoenzkeSchumacheretal.2016,
  author    = {Doege, N. and Hoenzke, S. and Schumacher, Fabian and Balzus, Benjamin and Colombo, Miriam and Hadam, S. and Rancan, F. and Blume-Peytavi, Ulrike and Schindler, A. and Ruehl, E. and Skov, P. and Church, Martin K. and Hedtrich, Sarah and Kleuser, Burkhard and Bodmeier, Roland and Vogt, A.},
  title     = {Ex vivo microdialysis used for the preclinical assessment of anti-inflammatory therapy},
  series = {Experimental dermatology : the official journal of the European Immunodermatology Society},
  volume    = {25},
  journal   = {Experimental dermatology : the official journal of the European Immunodermatology Society},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken},
  issn      = {0906-6705},
  pages     = {E32 -- E32},
  year      = {2016},
  language  = {en}
}
@article{ZaldenQuirinSchumacheretal.2019,
  author    = {Zalden, Peter and Quirin, Florian and Schumacher, Mathias and Siegel, Jan and Wei, Shuai and Koc, Azize and Nicoul, Matthieu and Trigo, Mariano and Andreasson, Pererik and Enquist, Henrik and Shu, Michael J. and Pardini, Tommaso and Chollet, Matthieu and Zhu, Diling and Lemke, Henrik and Ronneberger, Ider and Larsson, J{\"o}rgen and Lindenberg, Aaron M. and Fischer, Henry E. and Hau-Riege, Stefan and Reis, David A. and Mazzarello, Riccardo and Wuttig, Matthias and Sokolowski-Tinten, Klaus},
  title     = {Femtosecond x-ray diffraction reveals a liquid-liquid phase transition in phase-change materials},
  series = {Science},
  volume    = {364},
  journal   = {Science},
  number    = {6445},
  publisher = {American Assoc. for the Advancement of Science},
  address   = {Washington, DC},
  issn      = {0036-8075},
  doi       = {10.1126/science.aaw1773},
  pages     = {1062 -- 1067},
  year      = {2019},
  abstract  = {In phase-change memory devices, a material is cycled between glassy and crystalline states. The highly temperature-dependent kinetics of its crystallization process enables application in memory technology, but the transition has not been resolved on an atomic scale. Using femtosecond x-ray diffraction and ab initio computer simulations, we determined the time-dependent pair-correlation function of phase-change materials throughout the melt-quenching and crystallization process. We found a liquid-liquid phase transition in the phase-change materials Ag4In3Sb67Te26 and Ge15Sb85 at 660 and 610 kelvin, respectively. The transition is predominantly caused by the onset of Peierls distortions, the amplitude of which correlates with an increase of the apparent activation energy of diffusivity. This reveals a relationship between atomic structure and kinetics, enabling a systematic optimization of the memory-switching kinetics.},
  language  = {en}
}
@unpublished{BaretBelderBieretal.2012,
  author    = {Baret, Jean-Christophe and Belder, Detlev and Bier, Frank Fabian and Cao, Jialan and Gruschke, Oliver and Hardt, Steffen and Kirschbaum, Michael and Koehler, J. Michael and Schumacher, Soeren and Urban, G. A. and Viefhues, Martina},
  title     = {Contributors to the 10th Anniversary Germany issue},
  series = {LAB on a chip : miniaturisation for chemistry and biology},
  volume    = {12},
  journal   = {LAB on a chip : miniaturisation for chemistry and biology},
  number    = {3},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {1473-0197},
  doi       = {10.1039/c1lc90139g},
  pages     = {419 -- 421},
  year      = {2012},
  language  = {en}
}
@misc{CorstenGuentherNieslonyetal.2016,
  author    = {Corsten, Sabine and G{\"u}nther, Thomas and Nieslony, Julia and Fl{\"o}ther, Manfred and Rott, Anke and Sch{\"o}ppe, Doreen and K{\"o}sterke-Buchardt, Antje and Machleb, Franziska and Purat, Patricia and Euler, Harald A. and Breitenstein, Sarah and D{\"u}sterh{\"o}ft, Stefanie and Posse, Dorothea and Topaj, Nathalie and Golcher, Felix and Gagarina, Natalʹja Vladimirovna and Stegenwallner-Sch{\"u}tz, Maja Henny Katherine and Lassotta, Romy and Ferchland, Lisa and Adani, Flavia and Wotschack, Christiane and Klassert, Annegret and Festman, Julia and Schumacher, Rebecca and Burchert, Frank and Ablinger, Irene and Buttler, Rahel and Frank, Luis and Stadie, Nicole and Weiland, Linda and Netzebandt, Jonka and Frank, Ulrike and Bykova, Ksenia and Loppnow, Anna and Huckabee, Maggie-Lee and Krusche, Lisa},
  title     = {Spektrum Patholinguistik Band 9. Schwerpunktthema: Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie},
  series = {Spektrum Patholinguistik},
  journal   = {Spektrum Patholinguistik},
  editor    = {Fritzsche, Tom and Yetim, {\"O}zlem and Otto, Constanze and Adelt, Anne},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-385-5},
  issn      = {1866-9085},
  doi       = {10.25932/publishup-9665},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-96653},
  pages     = {vi, 269},
  year      = {2016},
  abstract  = {Das 9. Herbsttreffen Patholinguistik mit dem Schwerpunktthema "Lauter Laute: Phonologische Verarbeitung und Lautwahrnehmung in der Sprachtherapie" fand am 14.11.2015 in Potsdam statt. Das Herbsttreffen wird seit 2007 j{\"a}hrlich vom Verband f{\"u}r Patholinguistik e.V. (vpl) durchgef{\"u}hrt. Der vorliegende Tagungsband beinhaltet die vier Hauptvortr{\"a}ge zum Schwerpunktthema, die drei Kurzvortr{\"a}ge aus dem Spektrum Patholinguisitk sowie die Beitr{\"a}ge der Posterpr{\"a}sentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis.},
  language  = {de}
}
@article{BluethgenDormannPratietal.2012,
  author    = {Bl{\"u}thgen, Nico and Dormann, Carsten F. and Prati, Daniel and Klaus, Valentin H. and Kleinebecker, Till and Hoelzel, Norbert and Alt, Fabian and Boch, Steffen and Gockel, Sonja and Hemp, Andreas and M{\"u}ller, J{\"o}rg and Nieschulze, Jens and Renner, Swen C. and Sch{\"o}ning, Ingo and Schumacher, Uta and Socher, Stephanie A. and Wells, Konstans and Birkhofer, Klaus and Buscot, Francois and Oelmann, Yvonne and Rothenw{\"o}hrer, Christoph and Scherber, Christoph and Tscharntke, Teja and Weiner, Christiane N. and Fischer, Markus and Kalko, Elisabeth K. V. and Linsenmair, Karl Eduard and Schulze, Ernst-Detlef and Weisser, Wolfgang W.},
  title     = {A quantitative index of land-use intensity in grasslands integrating mowing, grazing and fertilization},
  series = {Basic and applied ecology : Journal of the Gesellschaft f{\"u}r {\"O}kologie},
  volume    = {13},
  journal   = {Basic and applied ecology : Journal of the Gesellschaft f{\"u}r {\"O}kologie},
  number    = {3},
  publisher = {Elsevier},
  address   = {Jena},
  issn      = {1439-1791},
  doi       = {10.1016/j.baae.2012.04.001},
  pages     = {207 -- 220},
  year      = {2012},
  abstract  = {Land use is increasingly recognized as a major driver of biodiversity and ecosystem functioning in many current research projects. In grasslands, land use is often classified by categorical descriptors such as pastures versus meadows or fertilized versus unfertilized sites. However, to account for the quantitative variation of multiple land-use types in heterogeneous landscapes, a quantitative, continuous index of land-use intensity (LUI) is desirable. Here we define such a compound, additive LUI index for managed grasslands including meadows and pastures. The LUI index summarizes the standardized intensity of three components of land use, namely fertilization, mowing, and livestock grazing at each site. We examined the performance of the LUI index to predict selected response variables on up to 150 grassland sites in the Biodiversity Exploratories in three regions in Germany(Alb, Hainich, Schorlheide). We tested the average Ellenberg nitrogen indicator values of the plant community, nitrogen and phosphorus concentration in the aboveground plant biomass, plant-available phosphorus concentration in the top soil, and soil C/N ratio, and the first principle component of these five response variables. The LUI index significantly predicted the principal component of all five response variables, as well as some of the individual responses. Moreover, vascular plant diversity decreased significantly with LUI in two regions (Alb and Hainich). Inter-annual changes in management practice were pronounced from 2006 to 2008, particularly due to variation in grazing intensity. This rendered the selection of the appropriate reference year(s) an important decision for analyses of land-use effects, whereas details in the standardization of the index were of minor importance. We also tested several alternative calculations of a LUI index, but all are strongly linearly correlated to the proposed index. The proposed LUI index reduces the complexity of agricultural practices to a single dimension and may serve as a baseline to test how different groups of organisms and processes respond to land use. In combination with more detailed analyses, this index may help to unravel whether and how land-use intensities, associated disturbance levels or other local or regional influences drive ecological processes.},
  language  = {en}
}
@article{SchweigertBuchholzSchumacheretal.2001,
  author    = {Schweigert, Florian J. and Buchholz, Ingeborg and Schumacher, A. and Gropp, J.},
  title     = {Effect of dietary ß-carotene on the accumulation of ß-carotene and vitamin A in plasma and tissues of gilts},
  year      = {2001},
  language  = {en}
}
@article{MuellerFinkeEbertetal.2018,
  author    = {M{\"u}ller, S. M. and Finke, Hannah and Ebert, Franziska and Kopp, Johannes Florian and Schumacher, Fabian and Kleuser, Burkhard and Francesconi, Kevin A. and Raber, G. and Schwerdtle, Tanja},
  title     = {Arsenic-containing hydrocarbons},
  series = {Archives of toxicology : official journal of EUROTOX},
  volume    = {92},
  journal   = {Archives of toxicology : official journal of EUROTOX},
  number    = {5},
  publisher = {Springer},
  address   = {Heidelberg},
  issn      = {0340-5761},
  doi       = {10.1007/s00204-018-2194-z},
  pages     = {1751 -- 1765},
  year      = {2018},
  abstract  = {Arsenic-containing hydrocarbons (AsHCs), a subgroup of arsenolipids found in fish and algae, elicit substantial toxic effects in various human cell lines and have a considerable impact on cellular energy levels. The underlying mode of action, however, is still unknown. The present study analyzes the effects of two AsHCs (AsHC 332 and AsHC 360) on the expression of 44 genes covering DNA repair, stress response, cell death, autophagy, and epigenetics via RT-qPCR in human liver (HepG2) cells. Both AsHCs affected the gene expression, but to different extents. After treatment with AsHC 360, flap structure-specific endonuclease 1 (FEN1) as well as xeroderma pigmentosum group A complementing protein (XPA) and (cytosine-5)-methyltransferase 3A (DNMT3A) showed time- and concentration-dependent alterations in gene expression, thereby indicating an impact on genomic stability. In the subsequent analysis of epigenetic markers, within 72 h, neither AsHC 332 nor AsHC 360 showed an impact on the global DNA methylation level, whereas incubation with AsHC 360 increased the global DNA hydroxymethylation level. Analysis of cell extracts and cell media by HPLC-mass spectrometry revealed that both AsHCs were considerably biotransformed. The identified metabolites include not only the respective thioxo-analogs of the two AsHCs, but also several arsenic-containing fatty acids and fatty alcohols, contributing to our knowledge of biotransformation mechanisms of arsenolipids.},
  language  = {en}
}
@misc{VoigtZimmermannStierLascheitetal.2019,
  author    = {Voigt-Zimmermann, Susanne and Stier, Karl-Heinz and Lascheit, Thomas and Kruse, Stephanie A. and Blickensdorff, Maria and F{\"o}rster, Theresa and Schumacher, Rebecca and Burchert, Frank and Ablinger, Irene and F{\"o}rster, Christine and Wahl, Michael and Schirmacher, Irene and Ostermann, Frank and Welke, Lisa-Marie and Frank, Ulrike and Zakari{\´a}s, Lilla and Salis, Christos and Wartenburger, Isabell and Krug, Ragna and St{\"u}bner, Hanna and Hoffmann, Sophie and Heide, Judith},
  title     = {Spektrum Patholinguistik Band 11. Schwerpunktthema: Gut gestimmt: Diagnostik und Therapie bei Dysphonie},
  number    = {11},
  editor    = {Fritzsche, Tom and Yetim, {\"O}zlem and Otto, Constanze and Adelt, Anne},
  publisher = {Universit{\"a}tsverlag Potsdam},
  address   = {Potsdam},
  isbn      = {978-3-86956-448-7},
  issn      = {1866-9085},
  doi       = {10.25932/publishup-41857},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-418574},
  pages     = {142},
  year      = {2019},
  abstract  = {Das 11. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Gut gestimmt: Diagnostik und Therapie bei Dysphonie« fand am 18.11.2017 in Potsdam statt. Das Herbsttreffen wird seit 2007 j{\"a}hrlich vom Verband f{\"u}r Patholinguistik e.V. (vpl) durchgef{\"u}hrt. Der vorliegende Tagungsband beinhaltet die Hauptvortr{\"a}ge zum Schwerpunktthema sowie Beitr{\"a}ge zu den Kurzvortr{\"a}gen »Spektrum Patholinguistik« und der Posterpr{\"a}sentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis.},
  language  = {de}
}
@article{ChakrabortyChenBornhorstetal.2015,
  author    = {Chakraborty, Sudipta and Chen, Pan and Bornhorst, Julia and Schwerdtle, Tanja and Schumacher, Fabian and Kleuser, Burkhard and Bowman, Aaron B. and Aschner, Michael A.},
  title     = {Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C-elegans},
  series = {Metallomics : integrated biometal science},
  volume    = {7},
  journal   = {Metallomics : integrated biometal science},
  number    = {5},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {1756-5901},
  doi       = {10.1039/c5mt00052a},
  pages     = {847 -- 856},
  year      = {2015},
  language  = {en}
}
@article{SchumacherChakrabortyKleuseretal.2015,
  author    = {Schumacher, Fabian and Chakraborty, Sudipta and Kleuser, Burkhard and Gulbins, Erich and Schwerdtle, Tanja and Aschner, Michael A. and Bornhorst, Julia},
  title     = {Highly sensitive isotope-dilution liquid-chromatography-electrospray ionization-tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegans},
  series = {Talanta : the international journal of pure and applied analytical chemistry},
  volume    = {144},
  journal   = {Talanta : the international journal of pure and applied analytical chemistry},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0039-9140},
  doi       = {10.1016/j.talanta.2015.05.057},
  pages     = {71 -- 79},
  year      = {2015},
  abstract  = {Dopamine (DA) and serotonin (SRT) are monoamine neurotransmitters that play a key role in regulating the central and peripheral nervous system. Their impaired metabolism has been implicated in several neurological disorders, such as Parkinson's disease and depression. Consequently, it is imperative to monitor changes in levels of these low-abundant neurotransmitters and their role in mediating disease. For the first time, a rapid, specific and sensitive isotope-dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of DA and SRT in the nematode Caenorhabditis elegans (C. elegans). This model organism offers a unique approach for studying the effect of various drugs and environmental conditions on neurotransmitter levels, given by the conserved DA and SRT biology, including synaptic release, trafficking and formation. We introduce a novel sample preparation protocol incorporating the usage of sodium thiosulfate in perchloric acid as extraction medium that assures high recovery of the relatively unstable neurotransmitters monitored. Moreover, the use of both deuterated internal standards and the multiple reaction monitoring (MRM) technique allows for unequivocal quantification. Thereby, to the best of our knowledge, we achieve a detection sensitivity that clearly exceeds those of published DA and SRT quantification methods in various matrices. We are the first to show that exposure of C elegans to the monoamine oxidase B (MAOB) inhibitor selegiline or the catechol-O-methyltransferase (COMT) inhibitor tolcapone, in order to block DA and SRT degradation, resulted in accumulation of the respective neurotransmitter. Assessment of a behavioral output of the dopaminergic system (basal slowing response) corroborated the analytical LC-MS/MS data. Thus, utilization of the C elegans model system in conjunction with our analytical method is well-suited to investigate drug-mediated modulation of the DA and SRT system in order to identify compounds with neuroprotective or regenerative properties. (C) 2015 Elsevier B.V. All rights reserved.},
  language  = {en}
}
@misc{ChakrabortyChenBornhorstetal.2015,
  author    = {Chakraborty, Sudipta and Chen, Pan and Bornhorst, Julia and Schwerdtle, Tanja and Schumacher, Fabian and Kleuser, Burkhard and Bowman, Aaron B. and Aschner, Michael A.},
  title     = {Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-99508},
  pages     = {10},
  year      = {2015},
  abstract  = {Overexposure to the essential metal manganese (Mn) can result in an irreversible condition known as manganism that shares similar pathophysiology with Parkinson's disease (PD), including dopaminergic (DAergic) cell loss that leads to motor and cognitive impairments. However, the mechanisms behind this neurotoxicity and its relationship with PD remain unclear. Many genes confer risk for autosomal recessive, early-onset PD, including the parkin/PARK2 gene that encodes for the E3 ubiquitin ligase Parkin. Using Caenorhabditis elegans (C. elegans) as an invertebrate model that conserves the DAergic system, we previously reported significantly increased Mn accumulation in pdr-1/parkin mutants compared to wildtype (WT) animals. For the current study, we hypothesize that this enhanced accumulation is due to alterations in Mn transport in the pdr-1 mutants. While no change in mRNA expression of the major Mn importer proteins (smf-1-3) was found in pdr-1 mutants, significant downregulation in mRNA levels of the putative Mn exporter ferroportin (fpn-1.1) was observed. Using a strain overexpressing fpn-1.1 in worms lacking pdr-1, we show evidence for attenuation of several endpoints of Mn-induced toxicity, including survival, metal accumulation, mitochondrial copy number and DAergic integrity, compared to pdr-1 mutants alone. These changes suggest a novel role of pdr-1 in modulating Mn export through altered transporter expression, and provides further support of metal dyshomeostasis as a component of Parkinsonism pathophysiology.},
  language  = {en}
}