@article{SeckerVoelkelTierschetal.2016,
  author    = {Secker, Christian and Voelkel, Antje and Tiersch, Brigitte and Koetz, Joachim and Schlaad, Helmut},
  title     = {Thermo-Induced Aggregation and Crystallization of Block Copolypeptoids in Water},
  series = {Macromolecules : a publication of the American Chemical Society},
  volume    = {49},
  journal   = {Macromolecules : a publication of the American Chemical Society},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {0024-9297},
  doi       = {10.1021/acs.macromol.5b02481},
  pages     = {979 -- 985},
  year      = {2016},
  abstract  = {Block copolypeptoids comprising a thermosensitive, crystallizable poly(N-(n-propyl)glycine) block and a watersoluble poly(N-methylglycine) block, P70My (y = 23, 42, 76, 153, and 290), were synthesized bY ring-opening polymerization of the corresponding N-alkylglycine N-carboxyanhydrides (NCAs) and examined according to their thermo-induced aggregation and crystallization in water by turbidimetty, micro-differential scanning calorimetry (micro-DSC); cryogenic scanning electron microscopy (cryo-SEM), analytical ultracentrifugation (AUC), and static light scattering (SLS). At a temperature above the cloud point temperature, the initially formed micellar aggregates started to crystallize and grow into larger complex assemblies of about 100-500 nm, exhibiting flower-like (P70M23), ellipsoidal (P70M42 and P70M72) or irregular shapes (P70M153 and.P70M290).},
  language  = {en}
}
@article{MaiRakhmatullinaBleeketal.2014,
  author    = {Mai, Tobias and Rakhmatullina, Ekaterina and Bleek, Katrin and Boye, Susanne and Yuan, Jiayin and Voelkel, Antje and Graewert, Marlies and Cheaib, Zeinab and Eick, Sigrun and G{\"u}nter, Christina and Lederer, Albena and Lussi, Adrian and Taubert, Andreas},
  title     = {Poly(ethylene oxide)-b-poly(3-sulfopropyl methacrylate) block copolymers for calcium phosphate mineralization and biofilm inhibition},
  series = {Biomacromolecules : an interdisciplinary journal focused at the interface of polymer science and the biological sciences},
  volume    = {15},
  journal   = {Biomacromolecules : an interdisciplinary journal focused at the interface of polymer science and the biological sciences},
  number    = {11},
  publisher = {American Chemical Society},
  address   = {Washington},
  issn      = {1525-7797},
  doi       = {10.1021/bm500888q},
  pages     = {3901 -- 3914},
  year      = {2014},
  abstract  = {Poly(ethylene oxide) (PEO) has long been used as an additive in toothpaste, partly because it reduces biofilm formation on teeth. It does not, however, reduce the formation of dental calculus or support the remineralization of dental enamel or dentine. The present article describes the synthesis of new block copolymers on the basis of PEO and poly(3-sulfopropyl methacrylate) blocks using atom transfer radical polymerization. The polymers have very large molecular weights (over 10(6) g/mol) and are highly water-soluble. They delay the precipitation of calcium phosphate from aqueous solution but, upon precipitation, lead to relatively monodisperse hydroxyapatite (HAP) spheres. Moreover, the polymers inhibit the bacterial colonization of human enamel by Streptococcus gordonii, a pioneer bacterium in oral biofilm formation, in vitro. The formation of well-defined HAP spheres suggests that a polymer-induced liquid precursor phase could be involved in the precipitation process. Moreover, the inhibition of bacterial adhesion suggests that the polymers could be utilized in caries prevention.},
  language  = {en}
}
@article{MaiBoyeYuanetal.2015,
  author    = {Mai, Tobias and Boye, Susanne and Yuan, Jiayin and Voelkel, Antje and Graewert, Marlies and G{\"u}nter, Christina and Lederer, Albena and Taubert, Andreas},
  title     = {Poly(ethylene oxide)-based block copolymers with very high molecular weights for biomimetic calcium phosphate mineralization},
  series = {RSC Advances},
  volume    = {5},
  journal   = {RSC Advances},
  number    = {125},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {2046-2069},
  doi       = {10.1039/c5ra20035k},
  pages     = {103494 -- 103505},
  year      = {2015},
  abstract  = {The present article is among the first reports on the effects of poly(ampholyte)s and poly(betaine) s on the biomimetic formation of calcium phosphate. We have synthesized a series of di- and triblock copolymers based on a non-ionic poly(ethylene oxide) block and several charged methacrylate monomers, 2-(trimethylammonium) ethyl methacrylate chloride, 2-((3-cyanopropyl)-dimethylammonium)ethyl methacrylate chloride, 3-sulfopropyl methacrylate potassium salt, and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide. The resulting copolymers are either positively charged, ampholytic, or betaine block copolymers. All the polymers have very high molecular weights of over 10(6) g mol(-1). All polymers are water-soluble and show a strong effect on the precipitation and dissolution of calcium phosphate. The strongest effects are observed with triblock copolymers based on a large poly(ethylene oxide) middle block (nominal M-n = 100 000 g mol(-1)). Surprisingly, the data show that there is a need for positive charges in the polymers to exert tight control over mineralization and dissolution, but that the exact position of the charge in the polymer is of minor importance for both calcium phosphate precipitation and dissolution.},
  language  = {en}
}