@article{PazPeterSchmidtetal.2012,
  author    = {Paz, Cristian and Peter, Martin G. and Schmidt, Bernd and Becerra, Jose and Gutierrez, Margarita and Astudillo, Luis and Silva, Mario},
  title     = {Synthesis and AChE inhibiting activity of 2, 4 substituted 6-Phenyl Pyrimidines},
  series = {Journal of the Chilean Chemical Society},
  volume    = {57},
  journal   = {Journal of the Chilean Chemical Society},
  number    = {3},
  publisher = {Sociedad Chilena De Quimica},
  address   = {Concepcion},
  issn      = {0717-9324},
  pages     = {1292 -- 1294},
  year      = {2012},
  abstract  = {Novel substituted pyrimidines were synthesized from methyl 2,4-dioxo-4-phenyl-butanoate (I-A) and urea, followed by Mitsunobu coupling of I-A with benzyl or allyl alcohol to give the corresponding 2-hydroxypyrimidine ethers in good yields. Saponification of I-A, followed by reaction with benzyl or allyl amines in the presence of TBTU yielded 2-hydroxy-6-phenyl-pyrimidine 4-carboxamides. AChE and BuChE assays revealed 2-hydroxy-6-phenyl-pyrimidine-4-carboxyallyamide as the most active compound, IC50=90 mu M, with no inhibition of BuChE.},
  language  = {en}
}