@article{PazBecerraSilvaetal.2015,
  author    = {Paz, Cristian and Becerra, Jose and Silva, Mario and Burgos, Viviana and Heydenreich, Matthias and Schmidt, Bernd and Thu Tran, and Vetter, Irina},
  title     = {(-)-Pentylsedinine, a New Alkaloid from the Leaves of Lobelia tupa with Agonist Activity at Nicotinic Acetylcholine Receptor},
  series = {Natural product communications : an international journal for communications and reviews},
  volume    = {10},
  journal   = {Natural product communications : an international journal for communications and reviews},
  number    = {8},
  publisher = {NPC},
  address   = {Westerville},
  issn      = {1934-578X},
  pages     = {1355 -- 1357},
  year      = {2015},
  abstract  = {Lobelia tupa, also called devil's tobacco, is a native plant from the center-south of Chile which has been used by the native people of Chile as a hallucinogenic and anesthetic plant. A new piperidine alkaloid, called pentylsedinine, which comprises five carbons in the side chain, was isolated from the aerial part of L. tupa, along with lobeline and lobelanidine. The structure was established on the basis of 1D and 2D NMR spectroscopy. While lobeline is a neutral antagonist at alpha 3 beta 2/alpha 3 beta 4 nAChR and alpha 7 nAChR, both lobelanidine and pentylsedinine act as partial agonists at nAChR},
  language  = {en}
}
@article{PazPeterSchmidtetal.2012,
  author    = {Paz, Cristian and Peter, Martin G. and Schmidt, Bernd and Becerra, Jose and Gutierrez, Margarita and Astudillo, Luis and Silva, Mario},
  title     = {Synthesis and AChE inhibiting activity of 2, 4 substituted 6-Phenyl Pyrimidines},
  series = {Journal of the Chilean Chemical Society},
  volume    = {57},
  journal   = {Journal of the Chilean Chemical Society},
  number    = {3},
  publisher = {Sociedad Chilena De Quimica},
  address   = {Concepcion},
  issn      = {0717-9324},
  pages     = {1292 -- 1294},
  year      = {2012},
  abstract  = {Novel substituted pyrimidines were synthesized from methyl 2,4-dioxo-4-phenyl-butanoate (I-A) and urea, followed by Mitsunobu coupling of I-A with benzyl or allyl alcohol to give the corresponding 2-hydroxypyrimidine ethers in good yields. Saponification of I-A, followed by reaction with benzyl or allyl amines in the presence of TBTU yielded 2-hydroxy-6-phenyl-pyrimidine 4-carboxamides. AChE and BuChE assays revealed 2-hydroxy-6-phenyl-pyrimidine-4-carboxyallyamide as the most active compound, IC50=90 mu M, with no inhibition of BuChE.},
  language  = {en}
}
@article{PazBecerraSilvaetal.2016,
  author    = {Paz, Cristian and Becerra, Jose and Silva, Mario and Cabrera-Pardo, Jaime and Burgos, Viviana and Heydenreich, Matthias and Schmidt, Bernd},
  title     = {(-)-8-Oxohobartine a New Indole Alkaloid from Aristotelia chilensis (Mol.) Stuntz},
  series = {Records of Natural Products},
  volume    = {10},
  journal   = {Records of Natural Products},
  publisher = {ACG Publications},
  address   = {Gebze-Kocaeli},
  issn      = {1307-6167},
  pages     = {68 -- 73},
  year      = {2016},
  abstract  = {The fruit of Aristotelia chilensis is considered a "super fruit" due to its high concentration of polyphenols displaying exceptional antioxidant capacities ORAC. From maqui berries have been reported several anthocyanins and glycosylated flavonoids, those benefits increase the attention to restudy the plant. From the leaves of A. chilensis several indole alkaloids have been reported, we in addition to aristoteline, aristone, aristoquinoline and 3-fromylindole report the spectroscopic elucidation of 8-oxo-9-dehydromakomakine (1), hobartine (2) and a new alkaloid named 8-oxohobartine (3). Compound 1 to 3 did not show bactericidal activity against E. coli and S. aureus till 200 mu g.},
  language  = {en}
}