@article{HolzBoeckerSchlierJennenSteinmetzetal.2018, author = {Holz, Nathalie E. and Boecker-Schlier, Regina and Jennen-Steinmetz, Christine and Hohm, Erika and Buchmann, Arlette F. and Blomeyer, Dorothea and Baumeister, Sarah and Plichta, Michael M. and Esser, G{\"u}nter and Schmidt, Martin and Meyer-Lindenberg, Andreas and Banaschewski, Tobias and Brandeis, Daniel and Laucht, Manfred}, title = {Early maternal care may counteract familial liability for psychopathology in the reward circuitry}, series = {Social Cognitive and Affective Neuroscience}, volume = {13}, journal = {Social Cognitive and Affective Neuroscience}, number = {11}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {1749-5016}, doi = {10.1093/scan/nsy087}, pages = {1191 -- 1201}, year = {2018}, abstract = {Reward processing is altered in various psychopathologies and has been shown to be susceptible to genetic and environmental influences. Here, we examined whether maternal care may buffer familial risk for psychiatric disorders in terms of reward processing. Functional magnetic resonance imaging during a monetary incentive delay task was acquired in participants of an epidemiological cohort study followed since birth (N = 172, 25 years). Early maternal stimulation was assessed during a standardized nursing/playing setting at the age of 3 months. Parental psychiatric disorders (familial risk) during childhood and the participants' previous psychopathology were assessed by diagnostic interview. With high familial risk, higher maternal stimulation was related to increasing activation in the caudate head, the supplementary motor area, the cingulum and the middle frontal gyrus during reward anticipation, with the opposite pattern found in individuals with no familial risk. In contrast, higher maternal stimulation was associated with decreasing caudate head activity during reward delivery and reduced levels of attention deficit hyperactivity disorder (ADHD) in the high-risk group. Decreased caudate head activity during reward anticipation and increased activity during delivery were linked to ADHD. These findings provide evidence of a long-term association of early maternal stimulation on both adult neurobiological systems of reward underlying externalizing behavior and ADHD during development.}, language = {en} } @article{HohmZohselSchmidtetal.2017, author = {Hohm, Erika and Zohsel, Katrin and Schmidt, Martin H. and Esser, G{\"u}nter and Brandeis, Daniel and Banaschewski, Tobias and Laucht, Manfred}, title = {Beeintr{\"a}chtigter Start ins Leben}, series = {Kindheit und Entwicklung}, volume = {26}, journal = {Kindheit und Entwicklung}, publisher = {Hogrefe}, address = {G{\"o}ttingen}, issn = {0942-5403}, doi = {10.1026/0942-5403/a000234}, pages = {210 -- 220}, year = {2017}, abstract = {Postpartale Depressionen sind h{\"a}ufige und schwerwiegende psychische Erkrankungen mit ung{\"u}nstigem Einfluss auf die kindliche Entwicklung. Als Haupttransmissionsweg gilt die fr{\"u}he Mutter-Kind-Interaktion. {\"U}ber die langfristigen Auswirkungen auf die Kinder im Erwachsenenalter und die Rolle der Interaktion liegen kaum Ergebnisse vor. Im Rahmen der Mannheimer Risikokinderstudie wurden postpartale Depressionen bis zwei Jahre nach der Geburt erfasst. Die kindliche Entwicklung wurde fortlaufend und die Mutter-Kind-Interaktion im Alter von 3 Monaten standardisiert erhoben. 28 Kinder postpartal depressiver und 107 Kinder gesunder M{\"u}tter konnten mit 25 Jahren untersucht werden. Beeintr{\"a}chtigungen der kognitiven und psychischen Entwicklung bei Kindern postpartal depressiver M{\"u}tter waren bis ins Erwachsenenalter nachweisbar. Responsives bzw. sensitives m{\"u}tterliches Verhalten wirkte der negativen Entwicklung entgegen. Dies betont die Bedeutung einer hohen Qualit{\"a}t der Mutter-Kind-Interaktion f{\"u}r die Entwicklung von Risikokindern.}, language = {de} } @article{ZohselHohmSchmidtetal.2017, author = {Zohsel, Katrin and Hohm, Erika and Schmidt, Martin H. and Brandeis, Daniel and Banaschewski, Tobias and Laucht, Manfred}, title = {Die langfristigen Auswirkungen von Fr{\"u}hgeburtlichkeit auf kognitive Entwicklung und Schulerfolg}, series = {Kindheit und Entwicklung}, volume = {26}, journal = {Kindheit und Entwicklung}, publisher = {Hogrefe}, address = {G{\"o}ttingen}, issn = {0942-5403}, doi = {10.1026/0942-5403/a000235}, pages = {221 -- 229}, year = {2017}, abstract = {In einer prospektiven L{\"a}ngsschnittstudie wurde der Zusammenhang zwischen fr{\"u}her Responsivit{\"a}t der Mutter und kognitiver Entwicklung ihrer fr{\"u}h- bzw. reifgeborenen Kinder untersucht. Im Alter von drei Monaten wurde daf{\"u}r die Mutter-Kind-Interaktion mittels Verhaltensbeobachtung erfasst. Bei n=351 der teilnehmenden Kinder (101 fr{\"u}hgeboren) wurde die allgemeine Intelligenz (IQ) im Alter von 11 Jahren und bei n=313 (85 fr{\"u}hgeboren) zus{\"a}tzlich der h{\"o}chste erreichte Schulabschluss bis 25 Jahren erhoben. Fr{\"u}hgeborene wiesen mit 11 Jahren einen signifikant niedrigeren IQ als Reifgeborene auf, nachdem f{\"u}r m{\"o}gliche konfundierende Faktoren kontrolliert worden war. Nur bei Fr{\"u}h-, nicht aber bei Reifgeborenen zeigte sich ein signifikanter positiver Zusammenhang zwischen m{\"u}tterlicher Responsivit{\"a}t und IQ. F{\"u}r die Wahrscheinlichkeit einen h{\"o}heren Schulabschluss (mind. Fachabitur) zu erreichen, fand sich weder ein signifikanter Effekt von Fr{\"u}hgeburtlichkeit noch von m{\"u}tterlicher Responsivit{\"a}t.}, language = {de} } @article{HohmLauchtZohseletal.2017, author = {Hohm, Erika and Laucht, Manfred and Zohsel, Katrin and Schmidt, Martin H. and Esser, G{\"u}nter and Brandeis, Daniel and Banaschewski, Tobias}, title = {Resilienz und Ressourcen im Verlauf der Entwicklung}, series = {Kindheit und Entwicklung}, volume = {26}, journal = {Kindheit und Entwicklung}, publisher = {Hogrefe}, address = {G{\"o}ttingen}, issn = {0942-5403}, doi = {10.1026/0942-5403/a000236}, pages = {230 -- 239}, year = {2017}, abstract = {Anhand von Daten der Mannheimer Risikokinderstudie, die sich mit der langfristigen Entwicklung von Kindern mit unterschiedlichen Risikobelastungen besch{\"a}ftigt, wird gezeigt, wie Schutzfaktoren aufseiten des Kindes und seines famili{\"a}ren Umfelds im Verlauf der Entwicklung wirksam werden und zur Entstehung von Resilienz beitragen k{\"o}nnen. Eine besondere Rolle kommt dabei positiven fr{\"u}hen Eltern-Kind-Beziehungen zu (sowohl Mutter- als auch Vater-Kind-Interaktionen). Daneben spielen auch Interaktionserfahrungen im Alter von zwei Jahren des Kindes eine bedeutsame Rolle; diese sch{\"u}tzen Risikokinder davor, eine ung{\"u}nstige Entwicklung zu nehmen und tragen dazu bei, dass sich Kinder, die in psychosozialen Hochrisikofamilien aufwachsen, trotz ung{\"u}nstiger „Startbedingungen" positiv entwickeln. Neben Merkmalen der sozialen Umwelt nehmen auch sprachliche, sozial-emotionale und internale Kompetenzen des Kindes im Entwicklungsverlauf eine wichtige Rolle ein. Diese Kompetenzen erm{\"o}glichen es Risikokindern auch unter widrigen Lebensumst{\"a}nden (psychosoziale Hochrisikofamilien, Aufwachsen in Armutsverh{\"a}ltnissen) erfolgreich zu bestehen. Dar{\"u}ber hinaus zeigt die Arbeit, dass Resilienz ein Pers{\"o}nlichkeitsmerkmal ist, das ab dem fr{\"u}hen Erwachsenenalter eine hohe Stabilit{\"a}t besitzt. Mit diesen Befunden verweist die Arbeit auf die große Bedeutung der Resilienz bei der Vorhersage der langfristigen Entwicklung von Risikokindern.}, language = {de} } @article{VianaWackermannFurtadoEsseretal.2006, author = {Viana-Wackermann, Paula C. and Furtado, Erikson F. and Esser, G{\"u}nter and Schmidt, Martin H. and Laucht, Manfred}, title = {Lower P300 amplitude in eight-year-old offspring of alcoholic fathers with a delinquent history}, issn = {0940-1334}, doi = {10.1007/s00406-006-0709-8}, year = {2006}, abstract = {The aim of the present study was to investigate the P300 amplitude as a possible vulnerability marker in children of alcoholic (COA) fathers with and without paternal delinquency. Event-related potentials (ERPs) of 122 children aged 8 years (63 boys, 59 girls) were compared depending on father's alcoholism subtype: 30 COAs without paternal delinquency, 10 COAs with paternal delinquency, and 82 children of non-alcoholic and non-delinquent fathers. ERPs were recorded from Fz, Cz, and Pz, using an auditory oddball paradigm. Sinus tones of 60 dB HL were presented binaurally at 1,000 Hz (standard stimulus) and 2,000 Hz (target stimulus), at a relative frequency ratio of 80:20. Two trial blocks of 250 stimuli each were collected. Results indicated that only COAs with paternal delinquency displayed significant differences from the control group, characterized by reduced P300 amplitude at frontal site and in the second trial block. Thus, the combination of fathers' alcoholism and delinquency was more likely to relate to attenuated P300 amplitude in the offspring than paternal alcoholism alone. Our results suggest that both alcoholic and delinquent family history appear to play a role in P300 amplitude reduction in the offspring.}, language = {en} } @article{LauchtHohmEsseretal.2007, author = {Laucht, Manfred and Hohm, E. and Esser, G{\"u}nter and Schmidt, Martin H. and Becker, Katja}, title = {Association between ADHD and smoking in adolescence : shared genetic, environmental and psychopathological factors}, issn = {0300-9564}, doi = {10.1007/s00702-007-0703-y}, year = {2007}, abstract = {The present study aimed to examine the extent to which the co-occurrence of ADHD and smoking in adolescents could be attributed to common genetic, environmental and psychopathological factors. Data are from an ongoing prospective study of the outcome of early risk factors. At age 15 years, 305 adolescents completed self-report questionnaires measuring tobacco consumption and deviant peer affiliations. Lifetime psychiatric diagnoses were obtained using standardized interviews. DNA was genotyped for the dopamine D4 receptor (DRD4) gene exon III polymorphism. Adolescents with a lifetime diagnosis of ADHD displayed significantly higher smoking activity than non-ADHD controls. A major component of this association could be accounted for by deviant peer affiliations and the comorbidity with oppositional-defiant and conduct disorder, while a minor part was attributable to DRD4 in males but not in females. These findings suggest that the association of ADHD with smoking relies on risk factors shared by the two behaviors.}, language = {en} } @article{LauchtHohmEsseretal.2005, author = {Laucht, Manfred and Hohm, E. and Esser, G{\"u}nter and Schmidt, Martin H.}, title = {Elevated risk of smoking in children with externalizing disorders}, issn = {1616-3443}, year = {2005}, abstract = {Background: Several studies have reported higher smoking rates among adolescents with externalizing disorders (attention-deficit hyperactivity disorder and conduct disorder) as compared to healthy controls. Objective: To follow the association between childhood externalizing disorders and smoking during development, to determine the type of problems most strongly related to later tobacco use, and to control for the influence of covarying factors. Methods: Participants were from a longitudinal study of a birth cohort of 384 children born with different perinatal and psychosocial risks. Standardized assessments of behavioral disorders between 2 and 11 years and of tobacco use at age 15 were obtained. Results: 15-year-olds with externalizing disorders between 2 and 11 years reported higher tobacco use than those without a history of disorder. This association could be followed back into early childhood and held up even after controlling for covariates. Conclusions: The findings suggest that childhood externalizing disorders may represent an independent risk factor for elevated tobacco use in adolescence}, language = {en} } @article{LauchtHomEsseretal.2005, author = {Laucht, Manfred and Hom, Erika and Esser, G{\"u}nter and Schmidt, Martin H.}, title = {Erh{\"o}htes Raucherrisiko von Kindern mit Aufmerksamkeits- und Verhaltensst{\"o}rungen}, year = {2005}, language = {de} } @article{LayIhleEsseretal.2005, author = {Lay, Barbara and Ihle, Wolfgang and Esser, G{\"u}nter and Schmidt, Martin H.}, title = {Juvenile-episodic, continued or adult-onset delinquency? Risk conditions analysed in a cohort of children followed up to the age of 25 years}, year = {2005}, language = {en} } @article{LauchtSchmidtEsser2003, author = {Laucht, Manfred and Schmidt, Martin and Esser, G{\"u}nter}, title = {Fr{\"u}hkindliche Regulationsst{\"o}rungen: Vorl{\"a}ufer von Verhaltensst{\"o}rungen des sp{\"a}teren Kindesalters?}, isbn = {3- 456-84036-5}, year = {2003}, language = {de} } @article{LauchtEsserSchmidt2002, author = {Laucht, Manfred and Esser, G{\"u}nter and Schmidt, Martin H.}, title = {Heterogene Entwicklung von Kindern postpartal depressiver M{\"u}tter}, issn = {0084-5345}, year = {2002}, language = {de} } @article{EsserSchmidt2002, author = {Esser, G{\"u}nter and Schmidt, Martin H.}, title = {Risikokinderstudien : Einf{\"u}hrung in den Themenschwerpunkt}, year = {2002}, language = {de} } @article{EsserSteigleiderLangeetal.2002, author = {Esser, G{\"u}nter and Steigleider, Petra and Lange, Sabine and Ihle, Wolfgang and Blanz, Bernhard and Schmidt, Martin H.}, title = {Die Validit{\"a}t des autobiographischen Ged{\"a}chtnisses : Ergebnisse einer prospektiven L{\"a}ngsschnittsstudie von der Kindheit bis zum Erwachsenenalter}, year = {2002}, abstract = {Die Validit{\"a}t des autobiographischen Ged{\"a}chtnisses wird kontrovers diskutiert, bislang fehlen prospektive L{\"a}ngsschnittstudien weitgehend. Die vorliegende Studie {\"u}berpr{\"u}ft die Validit{\"a}t des autobiographischen Ged{\"a}chtnisses anhand der Daten einer prospektiven epidemiologischen L{\"a}ngsschnittstudie, die in vier Untersuchungswellen 399 achtj{\"a}hrige Kinder bis zum Alter von 25 Jahren begleitete. Im Alter von 25 Jahren wurden die Erinnerungsleistungen der Probanden an Kernfakten, Erziehungsstil der Eltern, eigene psychische Probleme sowie Lebensereignisse aus Kindheit und Jugend mit Hilfe eines voll strukturierten Fragebogens erhoben. Mit Ausnahme der Kernfakten waren die Erinnerungsleistungen durchweg schlecht, intelligente Probanden zeigten insgesamt bessere Erinnerungsleistungen, junge Erwachsene mit psychischen St{\"o}rungen berichteten vermehrt auch fr{\"u}her nicht vorhandene Symptome. Die retrospektive Erfassung fr{\"u}herer Lebensereignisse, der Beziehung zu den Eltern und psychischer Auff{\"a}lligkeiten im Rahmen von Risikostudien und klinischen Studien ist sehr bedenklich. Schl{\"u}sselw{\"o}rter: Autobiographisches Ged{\"a}chtnis, Entwicklungspsychopathologie, Epidemiologie, Langzeitstudie, Methodik}, language = {de} } @article{IhleEsserSchmidtetal.2002, author = {Ihle, Wolfgang and Esser, G{\"u}nter and Schmidt, Martin H. and Blanz, Bernhard}, title = {Die Bedeutung von Risikofaktoren des Kindes- und Jugendalters f{\"u}r psychsiche St{\"o}rungen von der Kindheit bis ins fr{\"u}he Erwachsenenalter}, year = {2002}, abstract = {Fragestellung: Prospektive Bedeutung von Risikofaktoren des Kindes- und Jugendalters f{\"u}r externalisierende und internalisierende St{\"o}rungen. Methode: Prospektive L{\"a}ngsschnittstudie vom Grundschul- zum fr{\"u}hen Erwachsenenalter. 321 Personen nahmen an allen Untersuchungen im Alter von 8, 13, 18 und 25 Jahren teil. Ergebnisse: Es zeigte sich, daß psychische St{\"o}rungen in hohem Maße geschlechtsabh{\"a}ngig sind. Besonders groß waren die Unterschiede im fr{\"u}hen Erwachsenenalter, wobei internalisierende St{\"o}rungen bei Frauen und externalisierende St{\"o}rungen bei M{\"a}nnern deutlich {\"u}berwogen. Externalisierende St{\"o}rungen des Erwachsenenalters ließen sich besser vorhersagen als internalisierende St{\"o}rungen. Dies ließ sich vor allem durch die gr{\"o}ßere pr{\"a}diktive Bedeutung fr{\"u}her Risikofaktoren bis zum Alter von 8 Jahren erkl{\"a}ren. F{\"u}r die Vorhersage internalisierender St{\"o}rungen war hingegen der Einfluß der Risikofaktoren des sp{\"a}ten Jugendalters und des {\"U}bergangs zum Erwachsenenalter gr{\"o}ßer. 10\% der untersuchten Stichprobe wies persistente St{\"o}rungen auf und stellt damit eine Hochrisikogruppe dar. Dieser Verlaufstyp zeichnet sich durch stabil hohe Risikokonstellationen zu allen Untersuchungszeitpunkten aus. Schl{\"u}sselw{\"o}rter: Risikofaktoren, Pr{\"a}valenz, Geschlechtsunterschiede, Verlaufstypen, externalisierende St{\"o}rungen, internalisierende St{\"o}rungen, psychische St{\"o}rungen, Kindes- und Jugendalter, Erwachsenenalter Childhood and adolescent predictors of mental disorders from childhood to early adulthood. Abstract. Objectives: Prospective impact of child and adolescent risk factors on externalizing and internalizing disorders. Methods: Prospective longitudinal study from childhood to early adulthood. 321 persons participated at age 8, 13, 18 and 25 years. Results: Sex differences in the prevalence rates of mental disorders were found. The highest differences were found in early adulthood. Females showed higher rates of internalizing disorders, whereas males showed higher rates of externalizing disorders. Externalizing disorders in adulthood could be predicted better than internalizing disorders. This result could be explained by the greater predictive power of childhood risk factors for externalizing disorders. Risk factors of adolescence and the transmission period to adulthood played a more prominent role in the prediction of internalizing disorders. 10\% of the studied sample showed persistent disorders and was identified as a high-risk sample. This developmental pattern of mental disorders shows stable risk constellations from childhood to adulthood. Key words: risk factors, prevalence, sex differences, developmental patterns, externalizing disorders, internalizing disorders, mental disorders, childhood and adolescence, adulthood}, language = {de} } @article{SteigleiderLauchtEsseretal.2002, author = {Steigleider, Petra and Laucht, Manfred and Esser, G{\"u}nter and Schmidt, Martin H.}, title = {Beeintr{\"a}chtigte kognitive und motorische Leistungen bei 8-j{\"a}hrigen Kindern mit sehr niedrigem Geburtsgewicht}, issn = {0084-5345}, year = {2002}, language = {de} } @article{ZohselHolzHohmetal.2017, author = {Zohsel, Katrin and Holz, Nathalie E. and Hohm, Erika and Schmidt, Martin H. and Esser, G{\"u}nter and Brandeis, Daniel and Banaschewski, Tobias and Laucht, Manfred}, title = {Fewer self-reported depressive symptoms in young adults exposed to maternal depressed mood during pregnancy}, series = {Journal of Affective Disorders}, volume = {209}, journal = {Journal of Affective Disorders}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0165-0327}, doi = {10.1016/j.jad.2016.08.059}, pages = {155 -- 162}, year = {2017}, abstract = {Background: Depressed mood is prevalent during pregnancy, with accumulating evidence suggesting an impact on developmental outcome in the offspring. However, the long-term effects of prenatal maternal depression regarding internalizing psychopathology in the offspring are as yet unclear. Results: In n=85 young adults exposed to prenatal maternal depressed mood, no significantly higher risk for a diagnosis of depressive disorder was observed. However, they reported significantly lower levels of depressive symptoms. This association was especially pronounced when prenatal maternal depressed mood was present during the first trimester of pregnancy and when maternal mood was depressed pre- as well as postnatally. At an uncorrected level only, prenatal maternal depressed mood was associated with decreased amygdala volume. Limitations: Prenatal maternal depressed mood was not assessed during pregnancy, but shortly after childbirth. No diagnoses of maternal clinical depression during pregnancy were available. Conclusions: Self-reported depressive symptoms do not imply increased, but rather decreased symptom levels in young adults who were exposed to prenatal maternal depressed mood. A long-term perspective may be important when considering consequences of prenatal risk factors.}, language = {en} } @article{ZohselHohmSchmidtetal.2017, author = {Zohsel, Katrin and Hohm, Erika and Schmidt, Martin H. and Brandeis, Daniel and Banaschewski, Tobias and Laucht, Manfred}, title = {Long-Term Consequences of Early Psychosocial Risks}, series = {Kindheit und Entwicklung}, volume = {26}, journal = {Kindheit und Entwicklung}, number = {4}, publisher = {Hogrefe}, address = {G{\"o}ttingen}, issn = {0942-5403}, doi = {10.1026/0942-5403/a000233}, pages = {203 -- 209}, year = {2017}, abstract = {In einer prospektiven L{\"a}ngsschnittstudie wurden Auswirkungen fr{\"u}her psychosozialer Risiken bis ins junge Erwachsenenalter untersucht und dabei die Rolle von affektiver und behavioraler Dysregulation im Kindesalter als vermittelndem Faktor {\"u}berpr{\"u}ft. Drei Monate nach der Geburt wurde das Vorliegen von 11 psychosozialen Belastungsfaktoren erfasst. Im Alter von 8 - 15 Jahren wurde dreimal das Child Behavior Checklist-Dysregulationsprofil (CBCL-DP) erhoben. Mit 25 Jahren wurde ein Strukturiertes Klinisches Interview durchgef{\"u}hrt und 309 der Teilnehmer f{\"u}llten den Young Adult Self-Report aus. Fr{\"u}he psychosoziale Risiken gingen mit einem erh{\"o}hten Risiko f{\"u}r das Vorliegen eines Substanzmissbrauchs im jungen Erwachsenenalter sowie mit erh{\"o}htem externalisierendem und internalisierendem Problemverhalten einher. Der Zusammenhang zwischen fr{\"u}hen psychosozialen Risiken und sp{\"a}terem externalisierendem bzw. internalisierendem Problemverhalten wurde durch das CBCL-DP vermittelt.}, language = {de} } @article{EsserSchmidt2017, author = {Esser, G{\"u}nter and Schmidt, Martin H.}, title = {Die Mannheimer Risikokinderstudie}, series = {Kindheit und Entwicklung}, volume = {26}, journal = {Kindheit und Entwicklung}, publisher = {Hogrefe}, address = {G{\"o}ttingen}, issn = {0942-5403}, doi = {10.1026/0942-5403/a000232}, pages = {198 -- 202}, year = {2017}, abstract = {Die Mannheimer Risikokinderstudie untersucht die psychische Entwicklung und ihre St{\"o}rungen bei Kindern mit unterschiedlich ausgepr{\"a}gten Risiken mit dem Ziel, Empfehlungen f{\"u}r die Verbesserung der Pr{\"a}vention, Fr{\"u}herkennung und Fr{\"u}hbehandlung von psychischen St{\"o}rungen bei Kindern abzuleiten. Dazu begleitet sie eine Kohorte von anfangs 384 Kindern in ihrer Entwicklung von der Geburt bis zum Erwachsenenalter. Die Erhebungen fanden in regelm{\"a}ßigen Abst{\"a}nden statt, beginnend im Alter von 3 Monaten, mit 2 Jahren, 4;6, 8, 11, 15, 19, 22, 23 und 25 Jahren. Geplant ist eine weitere Erhebung mit ca. 30 Jahren.}, language = {de} } @article{MillenetLauchtHohmetal.2018, author = {Millenet, Sabina and Laucht, Manfred and Hohm, Erika and Jennen-Steinmetz, Christine and Hohmann, Sarah and Schmidt, Martin H. and Esser, G{\"u}nter and Banaschewski, Tobias and Brandeis, Daniel and Zohsel, Katrin}, title = {Sex-specific trajectories of ADHD symptoms from adolescence to young adulthood}, series = {European child and adolescent psychiatry : offical journal of the European Society for Child and Adolescent Psychiatry}, volume = {27}, journal = {European child and adolescent psychiatry : offical journal of the European Society for Child and Adolescent Psychiatry}, number = {8}, publisher = {Springer}, address = {New York}, issn = {1018-8827}, doi = {10.1007/s00787-018-1129-9}, pages = {1067 -- 1075}, year = {2018}, abstract = {Reports of current ADHD symptoms in adults with a childhood diagnosis of ADHD are often discrepant: While one subgroup reports a particularly high level of current ADHD symptoms, another reports—in contrast—a very low level. The reasons for this difference remain unclear. Although sex might play a moderating role, it has not yet been examined in this regard. In an epidemiological cohort study from birth to young adulthood, childhood ADHD diagnoses were assessed at the ages of 4.5, 8, and 11 years based on parent ratings. Sex-specific development of ADHD symptoms was analyzed from the age of 15 to 25 years via self-reported ADHD symptoms in participants with (n = 47) and without childhood ADHD (n = 289) using a random coefficient regression model. The congruence between parent reports and adolescents' self-ratings was examined, and the role of childhood ADHD diagnosis, childhood OCC/CD, and childhood internalizing disorder as possible sex-specific predictors of self-reported ADHD symptoms at age 25 years was investigated. With regard to self-reported ADHD symptoms, females with a childhood ADHD diagnosis reported significantly more ADHD symptoms compared to females without childhood ADHD and males with and without ADHD throughout adolescence and young adulthood. In contrast, males with childhood ADHD did not differ from control males either at age 15 or at age 25 years. Only in females did a childhood diagnosis of an externalizing disorder (ADHD and CD/ODD) predict self-reported ADHD symptoms by age 25 years. Our findings suggest that self-reports of young adults with a childhood diagnosis of ADHD are influenced by sex. Specifically, females with childhood ADHD report increased levels of ADHD symptoms upon reaching adulthood. To correctly evaluate symptoms and impairment in this subgroup, other, more objective, sources of information may be advisable, such as neurophysiological measures.}, language = {en} } @article{PitzerEsserSchmidtetal.2017, author = {Pitzer, Martina and Esser, G{\"u}nter and Schmidt, Martin H. and Hohm, Erika and Banaschewski, Tobias and Laucht, Manfred}, title = {Child regulative temperament as a mediator of parenting in the development of depressive symptoms}, series = {Journal of neural transmission}, volume = {124}, journal = {Journal of neural transmission}, publisher = {Springer}, address = {Wien}, issn = {0300-9564}, doi = {10.1007/s00702-017-1682-2}, pages = {631 -- 641}, year = {2017}, abstract = {Child temperament as well as parenting behaviors have been linked to adolescent depression. Beyond their main effects, the interplay between these factors is of interest. For example, in an interactive model, a differential susceptibility of temperamental variants to parenting has been suggested. However, so far, the differential susceptibility hypothesis has mostly been studied with a focus on externalizing disorders. On the other hand, parenting may shape the child's temperament and vice versa in a transactional process. In a prospective, longitudinal at-risk sample (163 boys, 176 girls), we assessed emotional (easy-difficult) and regulative (self-control) temperament at ages 4.5, and 8 years, respectively, as well as parenting quality at age 4.5 years using the HOME inventory. Hierarchical linear regression analysis was used to investigate the prediction of depressive symptoms at age 11, measured by the Child Depression Inventory, including interaction terms between the temperament variable and parenting. We additionally tested whether parenting was mediated by child temperament. As previously reported, both self-control and parenting were longitudinally associated with preadolescent depressive symptoms. There were no interactive effects between temperament and parenting. However, the effects of parenting were partly mediated by self-control. Our data do not support a differential susceptibility of temperamental variants in the development of preadolescent depression. However, our results are in line with the assumption that parenting may shape young children's temperament, with positive parenting in the early childhood fostering the development of regulative temperament.}, language = {en} } @article{PietzFaetkenheuerBurgardetal.1997, author = {Pietz, J. and F{\"a}tkenheuer, Brigitte and Burgard, P. and Armbruster, M. and Esser, G{\"u}nter and Schmidt, Martin H.}, title = {Psychiatric disorders in adult patients with early-treated phenylketonuria}, year = {1997}, language = {en} } @article{IhleEsserSchmidtetal.1997, author = {Ihle, Wolfgang and Esser, G{\"u}nter and Schmidt, Martin H. and Meyer-Probst, Bernhard}, title = {Famili{\"a}re Determinanten seelischer Gesundheit und Krankheit im Generations- und Ost-West-Vergleich.}, year = {1997}, language = {de} } @article{LauchtTreutleinBlomeyeretal.2009, author = {Laucht, Manfred and Treutlein, Jens and Blomeyer, Dorothea and Buchmann, Arlette F. and Schmid, Brigitte and Becker, Katja and Zimmermann, Ulrich S. and Schmidt, Martin H. and Esser, G{\"u}nter and Rietschel, Marcella and Banaschewski, Tobias}, title = {Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology : evidence from a high-risk community sample of young adults}, issn = {1461-1457}, doi = {10.1017/S1461145708009875}, year = {2009}, abstract = {Previous research examining gene-environment interaction (G x E) with regard to vulnerability to depression and anxiety has yielded conflicting results. The present study was designed to further investigate G x F between 5-HTTLPR and exposure to environmental adversity, using different phenotypic and genotypic characterizations as well as different types of adversity within a prospective study design. Data were available from an ongoing epidemiological cohort Study following the outcome of early risk factors from birth to adulthood. At age 19 yr, 309 participants (142 males, 167 females) were characterized on measures of depression and anxiety through interview and questionnaire (DSM-IV diagnosis, Beck Depression Inventory, Harm Avoidance). Environmental adversity was assessed at birth (family adversity), and at age 19 yr (stressful life events). Bi- and tri-allelic 5-HTTLPR genotypes were obtained from genomic DNA. Results indicated that depression and anxiety in 19-yr-olds were strongly associated with both family adversity and stressful life events. Individuals with the LL genotype of 5-HTTLPR who were exposed to high family adversity displayed significantly higher rates of depressive or anxiety disorders and had more depressive symptoms than those without either condition. This G x E replicates recent findings from an epidemiological cohort study of adolescents but is in contrast to many previous reports suggesting an interaction with the S allele. No evidence for G x E was obtained with regard to current stressful life events and trait anxiety. One possible source for the conflicting findings might be attributed to heterogeneity in depression phenotypes and environmental adversity.}, language = {en} } @article{LauchtTreutleinSchmidetal.2009, author = {Laucht, Manfred and Treutlein, Jens and Schmid, Brigitte and Blomeyer, Dorothea and Becker, Katja and Buchmann, Arlette F. and Schmidt, Martin H. and Esser, G{\"u}nter and Jennen-Steinmetz, Christine and Rietschel, Marcella and Zimmermann, Ulrich S. and Banaschewski, Tobias}, title = {Impact of psychosocial adversity on alcohol intake in young adults : moderation by the LL genotype of the serotonin transporter polymorphism}, issn = {0006-3223}, doi = {10.1016/j.biopsych.2009.02.010}, year = {2009}, abstract = {Background: Evidence from animal studies supports a role for serotonin transporter gene promoter polymorphism (5-HTTLPR) gene-environment interaction (G X E) in the development of excessive alcohol intake. Few studies in humans have been conducted on this topic, yielding inconsistent results. The present study aims to further explore G x E between 5-HTTLPR and exposure to psychosocial adversity on alcohol consumption in a high-risk community sample of young adults. Methods: Data were collected as part of the Mannheim Study of Children at Risk, an ongoing epidemiological cohort study following the outcome of early risk factors from birth into young adulthood. At age 19 years, 309 participants (142 male participants, 167 female participants) were genotyped for the biallelic and triallelic 5-HTTLPR and were administered a 45-day alcohol timeline follow-back interview, providing measures of the total number of drinks and the number of binge drinking days. Psychosocial adversity was assessed at birth (family adversity) and at age 19 (negative life events). Results: In contrast to various previous reports, a significant G x E emerged, indicating that, when exposed to high psychosocial adversity, individuals with the LL genotype of 5-HTTLPR exhibited more hazardous drinking than those carrying the S allele or those without exposure to adversity. This effect, which was confined to male participants, held both for different classifications of 5-HTTLPR and different types of adversity. Conclusions: One explanation for the discrepant results might be heterogeneity in alcohol phenotypes. While the L allele relates more strongly to early-onset alcoholism, the S allele may be linked more closely to alcohol use associated with anxiety and depression.}, language = {en} } @article{SchmidtGeroldEsser1998, author = {Schmidt, Martin H. and Gerold, M. and Esser, G{\"u}nter}, title = {Seelische Gesundheit versus psychische Auff{\"a}lligkeiten in einer repr{\"a}sentativen Stichprobe junger Erwachsener}, isbn = {3-540-64492-x}, year = {1998}, language = {de} } @article{WeindrichJennenSteinmetzLauchtetal.1998, author = {Weindrich, D. and Jennen-Steinmetz, Christine and Laucht, Manfred and Esser, G{\"u}nter and Schmidt, Martin H.}, title = {At risk for language disorders? : correlates and course of language disorders in preschool children born at risk}, issn = {0803-5253}, year = {1998}, language = {en} } @article{LauchtEsserSchmidt1998, author = {Laucht, Manfred and Esser, G{\"u}nter and Schmidt, Martin H.}, title = {Fr{\"u}he Mutter-Kind-Beziehung : Risiko- und Schutzfaktoren f{\"u}r die Entwicklung von Kindern mit organischen und psychosozialen Belastungen ; Ergebnisse einer prospektiven Studie von der Geburt bis zum Schulalter}, year = {1998}, abstract = {Die Entwicklung von Kindern, die in ihrer fr{\"u}hen Kindheit erh{\"o}hten Belastungen ausgesetzt waren, zeichnet sich durch eine grosse Variabilit{\"a}t aus. Welche Kinder besonders gef{\"a}hrdet sind und welchen es gelingt, Entwicklungsrisiken zu {\"u}berwinden, wird anhand von Daten der Mannheimer Risikokinderstudie aufgezeigt. Dabei handelt es sich um eine prospektive L{\"a}ngsschnittstudie an einer Kohorte von 362 Kindern, die in ihrer Entwicklung von der Geburt bis ins Schulalter begleitet werden. Die Ergebnisse bis zum Alter von acht Jahren machen deutlich, dass die Entwicklungsprognose von sehr kleinen Fr{\"u}hgeborenen und von Kindern postnatal depressiver M{\"u}tter davon abh{\"a}ngt, wie die fr{\"u}he Beziehung zwischen Mutter und Risikokind gelingt. Sie unterstreichen damit die besondere Bedeutung der fr{\"u}hen Mutter-Kind-Interaktion in der Entwicklung von Risikokindern.}, language = {de} } @article{ReisMeyerProbstEsseretal.1998, author = {Reis, Olaf and Meyer-Probst, Bernhard and Esser, G{\"u}nter and Ihle, Wolfgang and Schmidt, Martin H.}, title = {Ereignisbelastung, soziale Unterst{\"u}tzung und seelische Gesundheit zweier verbundener Generationen in Mannheim und Rostock}, isbn = {3-7799-0941-3}, year = {1998}, language = {de} } @article{LauchtSkowronekBeckeretal.2008, author = {Laucht, Manfred and Skowronek, Markus H. and Becker, Katja and Schulze, Thomas G. and Schmidt, Martin H. and Esser, G{\"u}nter and Rietschel, Marcella}, title = {Environmental risk factors and attention-deficit : hyperactivity discorder symptoms ; reply}, issn = {0003-990X}, year = {2008}, language = {en} } @article{PitzerEsserSchmidtetal.2007, author = {Pitzer, Martina and Esser, G{\"u}nter and Schmidt, Martin H. and Laucht, Manfred}, title = {Temperament in the developmental course : a longitudinal comparison of New York Longitudinal Study-derived dimensions with the Junior Temperament and Character Inventory}, issn = {0010-440X}, doi = {10.1016/j.comppsych.2007.05.007}, year = {2007}, abstract = {Objective: Despite theoretical discrepancies between different concepts of temperament, some core dimensions are thought to be common to the various models. We compared temperamental traits derived from the New York Longitudinal Study (NYLS) model and the Cloninger dimensions in the developmental course and investigated the associations of temperament with sex as well as with obstetric risks or psychosocial risks present at birth. - Methods: Participants were 151 boys and 157 girls born at differing degrees of obstetric and psychosocial risk from a longitudinal study on a high-risk community sample. In infancy and childhood, NYLS-derived temperamental characteristics were assessed by a highly structured parent interview and standardized behavioral observations. At age 15 years, the Junior Temperament and Character Inventory/1218 was administered. - Results: Moderate correlations were found between Junior Temperament and Character Inventory scales in adolescence and NYLS-derived factors in childhood. The psychosocial risk load seemed to influence the expression of novelty seeking or corresponding NYLS-derived factors, whereas the obstetric risks did not contribute to variation in temperament. Our findings further support highly sex-specific gene x environment interactions on temperament in the developmental course. - Conclusion: The content of our NYLS-derived factors and the specific type of association across different temperament constructs fit into the increasing consensus regarding a small number of higher-order temperamental traits. (c) 2007 Elsevier Inc. All rights reserved.}, language = {en} } @article{HoltmannBuchmannEsseretal.2011, author = {Holtmann, Martin and Buchmann, Arlette F. and Esser, G{\"u}nter and Schmidt, Martin H. and Banaschewski, Tobias and Laucht, Manfred}, title = {The child behavior checklist-dysregulation profile predicts substance use, suicidality, and functional impairment : a longitudinal analysis}, year = {2011}, abstract = {Recent studies have identified a Child Behavior Checklist profile that characterizes children with severe affective and behavioral dysregulation (CBCL-dysregulation profile, CBCL-DP). In two recent longitudinal studies the CBCL-DP in childhood was associated with heightened rates of comorbid psychiatric disorders, among them bipolar disorder, an increased risk for suicidality, and marked psychosocial impairment at young-adult follow-up. This is the first study outside the US that examines the longitudinal course of the CBCL-DP. Methods: We studied the diagnostic and functional trajectories and the predictive utility of the CBCL-DP in the Mannheim Study of Children at Risk, an epidemiological cohort study on the outcome of early risk factors from birth into adulthood. A total of 325 young adults (151 males, 174 females) participated in the 19-year assessment. Results: Young adults with a higher CBCL-DP score in childhood were at increased risk for substance use disorders, suicidality and poorer overall functioning at age 19, even after adjustment for parental education, family income, impairment and psychiatric disorders at baseline. Childhood dysregulation was not related to bipolar disorder in young adulthood. The CBCL-DP was neither a precursor of a specific pattern of comorbidity nor of comorbidity in general. Conclusions: Children with high CBCL-DP values are at risk for later severe, psychiatric symptomatology. The different developmental trajectories suggest that the CBCL-DP is not simply an early manifestation of a single disease process but might rather be an early developmental risk marker of a persisting deficit of self-regulation of affect and behavior.}, language = {en} } @article{EsserDinterJoergSchmidtetal.1996, author = {Esser, G{\"u}nter and Dinter-J{\"o}rg, Monika and Schmidt, Martin H. and Herrle, Johannes and Yantorno-Villalba, P. and Rose, Frauke and Laucht, Manfred}, title = {Bedeutung der Blickvermeidung im S{\"a}uglingsalter f{\"u}r den Entwicklungsstand des Kindes mit zwei und viereinhalb Jahren}, year = {1996}, language = {de} } @article{EsserFischerWyschkonetal.2007, author = {Esser, G{\"u}nter and Fischer, Sascha and Wyschkon, Anne and Laucht, Manfred and Schmidt, Martin H.}, title = {Vorboten hyperkinetischer St{\"o}rungen : Fr{\"u}herkennung im Kleinkindalter}, issn = {1422-4917}, doi = {10.1024/1422-4917.35.2.127}, year = {2007}, abstract = {Objectives: The prospective longitudinal Mannheim Study of Children at Risk followed the development of children from the age of 2 years up to the age of 8 years. Are there differences between the developmental risk load in toddlers (psychopathology, cognition, motor or neurological development. and educational differences) who suffer from a hyperactive disorder at age 8 and that of undisturbed children of the same age? Are there specific harbingers of hyperkinetic disorders for the group concerned? Methods: In terms of their developmental risk load at the age of 2 years, 26 primary school children with hyperkinetic disorders were compared to 241 healthy primary school children, as well as to 25 children of the same age with emotional disturbances and 30 children of the same age with socially disruptive behavior. Results: A significant combination of predictors of later hyperkinetic disorders at primary school age proved to be increased fidgetiness and irritability, as well as a reduced language comprehension, at the age of two. Conclusions: The predictive value of symptoms in early childhood for later hyperkinetic disorder in children of primaryschool age is higher than that of symptoms assessed in infancy, which although expected is without relevant specificity.}, language = {de} } @article{LauchtSchmidtEsser2007, author = {Laucht, Michael and Schmidt, Martin H. and Esser, G{\"u}nter}, title = {Problems of behavioral and emotional regulation in early infancy : precursors of psychiatric disorders in later childhood?}, isbn = {978-1-934019-17-7}, year = {2007}, language = {en} } @article{IhleEsserLauchtetal.2007, author = {Ihle, Wolfgang and Esser, G{\"u}nter and Laucht, Manfred and Schmidt, Martin H.}, title = {Geschlechtsunterschiede in der Entwicklung psychischer St{\"o}rungen}, isbn = {978-3-540-71627-3}, year = {2007}, language = {de} } @article{EsserFischerWyschkonetal.2007, author = {Esser, G{\"u}nter and Fischer, Sascha and Wyschkon, Anne and Laucht, Manfred and Schmidt, Martin H.}, title = {Vorboten hyperkinetischer St{\"o}rungen : Fr{\"u}herkennung bereits im S{\"a}uglingsalter m{\"o}glich?}, issn = {1422-4917}, doi = {10.1024/1422-4917.35.3.179}, year = {2007}, abstract = {Objectives: Are there any differences (organic, psychosocial, psychopathological, cognitive or educational, respectively differences in the motor or neurological development) between infants who later on at the age of 8 years suffer from a hyperactive disorder and those who later on at the same age are undisturbed? Are there specific harbingers for hyperactive disorders in the group concerned? Methods: With regard to their developmental risk load at the age of 3 months, 26 primary school children with hyperactive disorders were compared with 241 healthy children, 25 children with emotional disturbances, and 30 children with socially disruptive behaviour, all of the same age. Results: Identified as the most important predictors for the onset of hyperactive disorders were a reduced birth weight, the mother's origin from a shattered family, early contact impairments on the part of the child, and the mother's neglect of the infant. Conclusions: Altogether, however, the prediction of later hyperactivity in primary school children on the basis of salient features in the infant children remains unsatisfactory and unspecific.}, language = {de} } @article{BeckerElFaddaghSchmidtetal.2008, author = {Becker, Katja and El-Faddagh, Mahha and Schmidt, Martin H. and Esser, G{\"u}nter and Laucht, Manfred}, title = {Interaction of dopamine transporter genotype with prenatal smoke exposure on ADHD symptoms}, issn = {0022-3476}, year = {2008}, abstract = {Objective To demonstrate that children homozygous for the 10-repeat allele of the common dopamine transporter (DAT1) polymorphism who were exposed to maternal prenatal smoke exhibited significantly higher hyperactivity-impulsivity than children without these environmental or genetic risks. Study design We performed a prospective longitudinal study from birth into early adulthood monitoring the long-term outcome of early risk factors. Maternal prenatal smoking was determined during a standardized interview with the mother when the child was 3 months old. At age 15 years, 305 adolescents participated in genotyping for the DAT1 40 base pair variable number of tandem repeats polymorphism and assessment of inattention, hyperactivity-impulsivity, and oppositional defiant/conduct disorder symptoms with die Kiddie- Sads-Present and Lifetime Version. Results There was no bivariate association between DAT1 genotype, prenatal smoke exposure and symptoms of attention deficit hyperactivity disorder. However, a significant interaction between DAT1 genotype and prenatal smoke exposure emerged (P =.012), indicating that males with prenatal smoke exposure who were homozygous for the DAT1 10r allele had higher hyperactivity-impulsivity than males from all other groups. In females, no significant main effects of DAT1 genotype or prenatal smoke exposure or interaction effects on any symptoms were evident (all P >.25). Conclusions This study provides further evidence for the multifactorial nature of attention deficit hyperactivity disorder and the importance of studying both genetic and environmental factors and their interaction.}, language = {en} } @article{HohmannBeckerFellingeretal.2009, author = {Hohmann, Sarah and Becker, Katja and Fellinger, Johannes and Banaschewski, Tobias and Schmidt, Martin H. and Esser, G{\"u}nter and Laucht, Manfred}, title = {Evidence for epistasis between the 5-HTTLPR and the dopamine D4 receptor polymorphisms in externalizing behavior among 15-year-olds}, issn = {0300-9564}, doi = {10.1007/s00702-009-0290-1}, year = {2009}, abstract = {The present study aimed to clarify the functional role of genes in the dopamine and serotonin systems by examining whether polymorphisms in these genes are related to adolescent externalizing behavior either alone or in interaction with each other. Participants were selected from an ongoing prospective study of the outcome of early risk factors. At age 15 years, 298 adolescents (144 males, 154 females) completed the Youth Self Report, 296 primary caregivers the Child Behavior Checklist and 253 teachers the Teacher Report Form. DNA was genotyped for the DRD4 exon III VNTR and the 5-HTTLPR polymorphisms. Results revealed that individuals with the DRD4 7r allele reported significantly more externalizing behavior than carriers of other variants. In addition, a significant interaction emerged, indicating that adolescents carrying two copies of the 5-HTTLPR short allele and the DRD4 7r variant scored highest on aggressive and/or delinquent behavior compared to other genotypes. This result suggests an effect of 5-HTTLPR on externalizing behavior in the presence of DRD4 7r but no effect in its absence.}, language = {en} } @article{SchmidHohmBlomeyeretal.2007, author = {Schmid, Brigitte and Hohm, Erika and Blomeyer, Dorothea and Zimmermann, Ulrich S. and Schmidt, Martin H. and Esser, G{\"u}nter and Laucht, Manfred}, title = {Concurrent alcohol and tobacco use during early adolescence characterizes a group at risk}, issn = {0735-0414}, doi = {10.1093/alcalc/agm024}, year = {2007}, abstract = {Aims: To investigate whether concurrent alcohol and tobacco use during early adolescence characterizes a subgroup that differs from users of one substance only regarding several risk factors for later substance use problems. Methods: Participants were from a prospective longitudinal cohort study of 384 children at risk for later psychopathology, with the majority being born with obstetric complications and psychosocial adversities. Assessments of adolescent drug consumption and related intrapersonal characteristics were obtained at age 15. Results: Compared to consumers of alcohol only, 15-year-olds drinking and smoking during the same time period (past 4 weeks) had significantly higher levels of consumption and more excessive use of alcohol, started drinking at an earlier age, had higher scores on the Fagerstrom Test for Nicotine Dependence, and more cannabis use. This group could be distinguished from users of alcohol only by higher novelty seeking and more positive alcohol effect expectancies. Compared to consumers of tobacco only, concurrent users reported higher nicotine dependence and more cannabis use. No significant differences were observed regarding frequency and age at initiation of tobacco use, tobacco-related sensitivity, self- efficacy and instrumentality as well as novelty seeking. Conclusions: Concurrent alcohol and tobacco use during early adolescence is associated with characteristics that are well known as risk factors for later alcohol use problems and dependence and that should be targeted by prevention programs.}, language = {en} } @article{IhleEsserSchmidt1997, author = {Ihle, Wolfgang and Esser, G{\"u}nter and Schmidt, Martin H.}, title = {Genese und Verlauf von emotionalen St{\"o}rungen von der KIndheit bis ins Erwachsenenalter}, year = {1997}, language = {de} } @article{LauchtEsserSchmidt1997, author = {Laucht, Manfred and Esser, G{\"u}nter and Schmidt, Martin H.}, title = {Wovor sch{\"u}tzen Schutzfaktoren? : Anmerkungen zu einem popul{\"a}ren Konzept der modernen Gesundheitsforschung}, year = {1997}, language = {de} } @article{LauchtEsserSchmidt1997, author = {Laucht, Manfred and Esser, G{\"u}nter and Schmidt, Martin H.}, title = {Developmental outcome of infants born with biological and psychosocial risks}, year = {1997}, language = {en} } @article{SchmidtEsserLaucht1997, author = {Schmidt, Martin H. and Esser, G{\"u}nter and Laucht, Manfred}, title = {Die Entwicklung nach biologischen und psychsozialen Risiken in der fr{\"u}hen Kindheit}, year = {1997}, language = {de} } @article{IhleEsserSchmidt1997, author = {Ihle, Wolfgang and Esser, G{\"u}nter and Schmidt, Martin H.}, title = {Lebensereignisse : Ursache oder Folge von psychischen St{\"o}rungen.}, year = {1997}, language = {de} } @article{EsserSchmidt1997, author = {Esser, G{\"u}nter and Schmidt, Martin H.}, title = {Psychische Probleme des Jugendalters : Ergebnisse einer prospektiven epidemiologischer L{\"a}ngsschnittsstudie von 8-18 Jahren}, year = {1997}, language = {de} } @article{EsserWyschkonSchmidtetal.2008, author = {Esser, G{\"u}nter and Wyschkon, Anne and Schmidt, Martin H. and Blanz, Bernhard and Ihle, Wolfgang}, title = {Ein Entwicklungsmodell des Substanzmissbrauchs im fr{\"u}hen Erwachsenenalter}, issn = {0942-5403}, doi = {10.1026/0942-5403.17.1.31}, year = {2008}, language = {de} } @article{HomBlomeyerSchmidtetal.2007, author = {Hom, Erika and Blomeyer, Dorothea and Schmidt, Martin H. and Esser, G{\"u}nter and Laucht, Manfred}, title = {Jugendliche die fr{\"u}hzeitig rauchen und trinken : eine Risikogruppe?}, issn = {1661-4747}, doi = {10.1024/1661-4747.55.3.155}, year = {2007}, abstract = {Epidemiological studies have reported elevated rates of legal drug consumption among adolescents in Germany. The aim of this study was to ascertain patterns and parameters of smoking and drinking in early-users as well as to examine possible determinants of risky patterns of use. Participants were from a longitudinal study of a birth cohort of 384 children at risk. Assessments of adolescent drug consumption as well as of individual and social determinants were obtained at age 15. Adolescents drinking and smoking during the same period (past four weeks) were characterized by more excessive and impulsive consumption and by higher rates of cannabis use. No specific determinants of concurrent use could be found. These findings suggest that adolescents displaying early concurrent tobacco and alcohol use may be at higher risk for substance use problems and should be targeted by prevention programs.}, language = {de} } @article{SchmidtEsserIhleetal.2009, author = {Schmidt, Martin H. and Esser, G{\"u}nter and Ihle, Wolfgang and Lay, Barbara}, title = {Die Bedeutung psychischer und famili{\"a}rer Faktoren f{\"u}r die Delinquenzentwicklung bis ins Erwachsenenalter}, issn = {0026-9301}, year = {2009}, abstract = {Es werden Befunde aus einer prospektiven Laengsschnittstudie praesentiert, in der 321 Probanden im Alter von 8, 13, 18 und 25 Jahren untersucht werden konnten; ihre Dunkelfelddelinquenz wurde mit 18 und 25 Jahren erfasst. Wir suchten nach Assoziationen zur Delinquenzentwicklung und erwarteten Unterschiede zwischen auf das Jugendalter beschraenkter gegenueber ins fruehe Erwachsenenalter fortgesetzter sowie spaet, d.h. nach dem Alter von 18 Jahren, beginnender Delinquenz. Wir fanden gemeinsame Risikofaktoren und fuer die drei Verlaufstypen spezifische Risikokonstellationen, die eher im Jugendalter als in der Kindheit identifiziert wurden. Widrige familiaere Bedingungen, Entwicklungsverzoegerungen und psychische Stoerungen scheinen mit Delinquenz als eher persistentem Verhalten assoziiert.}, language = {de} } @article{PitzerEsserSchmidtetal.2009, author = {Pitzer, Martina and Esser, G{\"u}nter and Schmidt, Martin H. and Laucht, Manfred}, title = {Temperamental predictors of externalizing problems among boys and girls : a longitudinal study in a high-risk sample from ages 3 months to 15 years}, issn = {0940-1334}, doi = {10.1007/s00406-009-0009-1}, year = {2009}, abstract = {In a high-risk community sample, we examined the role of regulative temperament and emotionality as well as the extent of gender specificity in the development of externalizing problems. 151 boys and 157 girls born at differing degrees of obstetric and psychosocial risk were followed from birth into adolescence. In infancy and childhood, NYLS- derived temperamental characteristics were assessed by a highly structured parent interview and standardized behavioral observations. At age 15 years, externalizing problems were measured by the Child Behavior Checklist. As revealed by multiple linear regression and logistic regression, low regulative abilities predicted adolescent behavioral and attentional problems over and above obstetric and psychosocial risks. Gender specificity was found in the strength of the association rather than in the kind with a stronger long-term prediction from infant and toddler temperament in girls. Compared to regulative abilities, temperament factors describing aspects of mood and fear/withdrawal versus approach tendencies played a minor role in the development of externalizing problems. Findings are discussed in terms of gender-specific risk factors and possible differential developmental trajectories to subtypes of disruptive behavior.}, language = {en} } @article{SchmidBlomeyerBeckeretal.2009, author = {Schmid, Brigitte and Blomeyer, Dorothea and Becker, Katja and Treutlein, Jens and Zimmermann, Ulrich S. and Buchmann, Arlette F. and Schmidt, Martin H. and Esser, G{\"u}nter and Banaschewski, Tobias and Rietschel, Marcella and Laucht, Manfred}, title = {The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19-year-olds}, issn = {1355-6215}, doi = {10.1111/j.1369-1600.2009.00171.x}, year = {2009}, abstract = {Recent evidence suggests that heterogeneity in the age at onset could explain the inconsistent findings of association studies relating the dopamine transporter (DAT1) gene with alcohol and nicotine consumption. The aim of this study was to examine interactions between two DAT1 polymorphisms and different initiation ages with regard to alcohol and tobacco consumption levels and dependence. Two hundred and ninety-one young adults (135 males, 156 females) participating in the Mannheim Study of Children at Risk were genotyped for the 40-bp variable number of tandem repeats (VNTR) and rs27072 polymorphisms of DAT1. Age at initiation was assessed at age 15 and 19 years. Information about current alcohol and tobacco consumption was obtained at age 19 years using self-report measures and structured interviews. Results suggest that age at onset of intensive consumption moderated the association of the DAT1 gene with early adult substance use and dependence, revealing a DAT1 effect only among individuals homozygous for the 10r allele of the 40-bp VNTR who had started daily smoking or being intoxicated early in life. Equally, carriers of the T allele of the rs27072 polymorphism reporting an early age at first intoxication showed higher current alcohol consumption at age 19 years. In contrast, no interaction between rs27072 and the age at first cigarette with regard to later smoking was observed. These findings provide evidence that the DAT1 gene interacts with an early heavy or regular drug exposure of the maturing adolescent brain to predict substance (ab)use in young adulthood. Further studies are required to confirm these findings.}, language = {en} }