@article{CywinskiIdzikCranfieldetal.2010,
  author    = {Cywinski, Piotr J. and Idzik, Krzysztof R. and Cranfield, Charles G. and Beckert, Rainer and Mohr, Gerhard J.},
  title     = {Synthesis and sensing properties of a new carbazole fluorosensor for detection of abacavir},
  issn      = {1061-0278},
  doi       = {10.1080/10610278.2010.506541},
  year      = {2010},
  abstract  = {An abacavir-targeted fluorosensor based on the carbazole moiety has been synthesised and characterised. Recognition of abacavir is by base pairing between a uracil moiety present in the fluorosensor and the guanine moiety of abacavir. The fluorosensor exhibits five-fold quenching in the presence of 50M abacavir. Its sensitivity to abacavir is superior to that of other reverse transcriptase inhibitors: zidovudine, lamivudine and didanosine. Due to its high sensitivity, this fluorosensor has the potential to be used in multi-analyte array-based detection platforms as well as in microfluidics systems.},
  language  = {en}
}
@article{IdzikCywinskiCranfieldetal.2011,
  author    = {Idzik, Krzysztof Ryszard and Cywinski, Piotr J. and Cranfield, Charles G. and Mohr, Gerhard J. and Beckert, Rainer},
  title     = {Molecular recognition of the antiretroviral drug abacavir towards the development of a novel carbazole-based fluorosensor},
  series = {Journal of fluorescence},
  volume    = {21},
  journal   = {Journal of fluorescence},
  number    = {3},
  publisher = {Springer},
  address   = {New York},
  issn      = {1053-0509},
  doi       = {10.1007/s10895-010-0798-7},
  pages     = {1195 -- 1204},
  year      = {2011},
  abstract  = {Due to their optical and electro-conductive attributes, carbazole derivatives are interesting materials for a large range of biosensor applications. In this study, we present the synthesis routes and fluorescence evaluation of newly designed carbazole fluorosensors that, by modification with uracil, have a special affinity for antiretroviral drugs via either Watson-Crick or Hoogsteen base pairing. To an N-octylcarbazole-uracil compound, four different groups were attached, namely thiophene, furane, ethylenedioxythiophene, and another uracil; yielding four different derivatives. Photophysical properties of these newly obtained derivatives are described, as are their interactions with the reverse transcriptase inhibitors such as abacavir, zidovudine, lamivudine and didanosine. The influence of each analyte on biosensor fluorescence was assessed on the basis of the Stern-Volmer equation and represented by Stern-Volmer constants. Consequently we have demonstrated that these structures based on carbazole, with a uracil group, may be successfully incorporated into alternative carbazole derivatives to form biosensors for the molecular recognition of antiretroviral drugs.},
  language  = {en}
}
@misc{IdzikCywinskiCranfieldetal.2011,
  author    = {Idzik, Krzysztof Ryszard and Cywinski, Piotr J. and Cranfield, Charles G. and Mohr, Gerhard J. and Beckert, Rainer},
  title     = {Molecular recognition of the antiretroviral drug Abacavir},
  series = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  journal   = {Postprints der Universit{\"a}t Potsdam : Mathematisch Naturwissenschaftliche Reihe},
  number    = {847},
  issn      = {1866-8372},
  doi       = {10.25932/publishup-43037},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-430372},
  pages     = {1195 -- 1204},
  year      = {2011},
  abstract  = {Due to their optical and electro-conductive attributes, carbazole derivatives are interesting materials for a large range of biosensor applications. In this study, we present the synthesis routes and fluorescence evaluation of newly designed carbazole fluorosensors that, by modification with uracil, have a special affinity for antiretroviral drugs via either Watson-Crick or Hoogsteen base pairing. To an N-octylcarbazole-uracil compound, four different groups were attached, namely thiophene, furane, ethylenedioxythiophene, and another uracil; yielding four different derivatives. Photophysical properties of these newly obtained derivatives are described, as are their interactions with the reverse transcriptase inhibitors such as abacavir, zidovudine, lamivudine and didanosine. The influence of each analyte on biosensor fluorescence was assessed on the basis of the Stern-Volmer equation and represented by Stern-Volmer constants. Consequently we have demonstrated that these structures based on carbazole, with a uracil group, may be successfully incorporated into alternative carbazole derivatives to form biosensors for the molecular recognition of antiretroviral drugs.},
  language  = {en}
}
@article{LaprestaFernandezCywinskiMoroetal.2009,
  author    = {Lapresta-Fern{\´a}ndez, Alejandro and Cywinski, Piotr J. and Moro, Artur J. and Mohr, Gerhard J.},
  title     = {Fluorescent polyacrylamide nanoparticles for naproxen recognition},
  issn      = {1618-2642},
  doi       = {10.1007/s00216-009-3007-2},
  year      = {2009},
  abstract  = {We present the synthesis of fluorescent acrylamide nanoparticles (FANs) capable of recognizing non-steroidal anti-inflammatory drugs (NSAIDs) in buffered aqueous solutions. Within this important group, we selected naproxen, one of the 2-arylpropionic acids (profens), due to its use for the treatment of moderate pain, fever, and inflammation. The nanosensors were prepared under mild conditions of inverse microemulsion polymerization using aqueous acrylamide as the monomer and N,N'-methylenebisacrylamide as the crosslinker, employing the surfactants polyoxyethylene-4-lauryl ether (Brij (R) 30) and sodium bis(2-ethylhexyl) sulfosuccinate in hexane. Furthermore, a fluorescent monomer, (E)-4-[4- (dimethylamino)styryl]-1-[4-(methacryloyloxymethyl)benzyl]pyridinium chloride (mDMASP) has been synthesized and incorporated into the nanoparticles. The nanosensors exhibit a broad absorbance at around 460 nm and a structureless fluorescence band with maximum at 590 nm in 0.5 M phosphate buffer (pH=7.2). The recognition process is performed on the basis of ionic interactions which are monitored by the fluorescence increase at 590 nm upon addition of different concentrations of naproxen. The FANs show a size distribution in the range of 20-80 nm, with a hydrodynamic diameter of 34 nm. In order to assess the selectivity of the FANs, a systematic study was conducted on the effect produced by drugs and biomolecules that could interfere with the analysis of naproxen.},
  language  = {en}
}
@misc{SuriyanarayananCywinskiMoroetal.2012,
  author    = {Suriyanarayanan, Subramanian and Cywinski, Piotr J. and Moro, Artur J. and Mohr, Gerhard J. and Kutner, Wlodzimierz},
  title     = {Chemosensors based on molecularly imprinted polymers},
  series = {Topics in current chemistry},
  volume    = {325},
  journal   = {Topics in current chemistry},
  number    = {4},
  editor    = {Haupt, K},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-642-28421-2},
  issn      = {0340-1022},
  doi       = {10.1007/128_2010_92},
  pages     = {165 -- 265},
  year      = {2012},
  language  = {en}
}