@misc{KoseskaZaikinKurthsetal.2009,
  author    = {Koseska, Aneta and Zaikin, Alexey and Kurths, J{\"u}rgen and Garc{\´i}a-Ojalvo, Jordi},
  title     = {Timing cellular decision making under noise via cell-cell communication},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-45260},
  year      = {2009},
  abstract  = {Many cellular processes require decision making mechanisms, which must act reliably even in the unavoidable presence of substantial amounts of noise. However, the multistable genetic switches that underlie most decision-making processes are dominated by fluctuations that can induce random jumps between alternative cellular states. Here we show, via theoretical modeling of a population of noise-driven bistable genetic switches, that reliable timing of decision-making processes can be accomplished for large enough population sizes, as long as cells are globally coupled by chemical means. In the light of these results, we conjecture that cell proliferation, in the presence of cell-cell communication, could provide a mechanism for reliable decision making in the presence of noise, by triggering cellular transitions only when the whole cell population reaches a certain size. In other words , the summation performed by the cell population would average out the noise and reduce its detrimental impact.},
  language  = {en}
}
@article{KoseskaVolkovKurths2009,
  author    = {Koseska, Aneta and Volkov, Evgenij and Kurths, J{\"u}rgen},
  title     = {Detuning-dependent dominance of oscillation death in globally coupled synthetic genetic oscillators},
  issn      = {0295-5075},
  doi       = {10.1209/0295-5075/85/28002},
  year      = {2009},
  abstract  = {We study dynamical regimes of globally coupled genetic relaxation oscillators in the presence of small detuning. Using bifurcation analysis, we find that under strong coupling via the slow variable, the detuning can eliminate standard oscillatory solutions in a large region of the parameter space, providing the dominance of oscillation death. This result is substantially different from previous results on oscillation quenching, where for homogeneous populations, the coexistence of oscillation death and limit cycle oscillations is always present. We propose further that this effect of detuning-dependent dominance could be a powerful regulator of genetic network's dynamics.},
  language  = {en}
}