@article{VerganiCarminatiFerrarietal.2012,
  author    = {Vergani, Marco and Carminati, Marco and Ferrari, Giorgio and Landini, Ettore and Caviglia, Claudia and Heiskanen, Arto and Comminges, Clement and Zor, Kinga and Sabourin, David and Dufva, Martin and Dimaki, Maria and Raiteri, Roberto and Wollenberger, Ursula and Emneus, Jenny and Sampietro, Marco},
  title     = {Multichannel bipotentiostat integrated with a microfluidic platform for electrochemical real-time monitoring of cell cultures},
  series = {IEEE Transactions on biomedical circuits and systems},
  volume    = {6},
  journal   = {IEEE Transactions on biomedical circuits and systems},
  number    = {5},
  publisher = {Inst. of Electr. and Electronics Engineers},
  address   = {Piscataway},
  issn      = {1932-4545},
  doi       = {10.1109/TBCAS.2012.2187783},
  pages     = {498 -- 507},
  year      = {2012},
  abstract  = {An electrochemical detection system specifically designed for multi-parameter real-time monitoring of stem cell culturing/differentiation in a microfluidic system is presented. It is composed of a very compact 24-channel electronic board, compatible with arrays of microelectrodes and coupled to a microfluidic cell culture system. A versatile data acquisition software enables performing amperometry, cyclic voltammetry and impedance spectroscopy in each of the 12 independent chambers over a 100 kHz bandwidth with current resolution down to 5 pA for 100 ms measuring time. The design of the platform, its realization and experimental characterization are reported, with emphasis on the analysis of impact of input capacitance (i.e., microelectrode size) and microfluidic pump operation on current noise. Programmable sequences of successive injections of analytes (ferricyanide and dopamine) and rinsing buffer solution as well as the impedimetric continuous tracking for seven days of the proliferation of a colony of PC12 cells are successfully demonstrated.},
  language  = {en}
}