@article{GiraudierVenturaBortWendtetal.2022, author = {Giraudier, Manon and Ventura-Bort, Carlos and Wendt, Julia and Lischke, Alexander and Weymar, Mathias}, title = {Memory advantage for untrustworthy faces}, series = {PLoS one}, volume = {17}, journal = {PLoS one}, number = {2}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0264034}, pages = {11}, year = {2022}, abstract = {The Covid-19 pandemic imposed new constraints on empirical research and forced researchers to transfer from traditional laboratory research to the online environment. This study tested the validity of a web-based episodic memory paradigm by comparing participants' memory performance for trustworthy and untrustworthy facial stimuli in a supervised laboratory setting and an unsupervised web setting. Consistent with previous results, we observed enhanced episodic memory for untrustworthy compared to trustworthy faces. Most importantly, this memory bias was comparable in the online and the laboratory experiment, suggesting that web-based procedures are a promising tool for memory research.}, language = {en} } @misc{GiraudierVenturaBortWeymar2020, author = {Giraudier, Manon and Ventura-Bort, Carlos and Weymar, Mathias}, title = {Transcutaneous Vagus Nerve Stimulation (tVNS) Improves High-Confidence Recognition Memory but Not Emotional Word Processing}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, number = {649}, issn = {1866-8364}, doi = {10.25932/publishup-47412}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-474125}, pages = {15}, year = {2020}, abstract = {Previous clinical research found that invasive vagus nerve stimulation (VNS) enhanced word recognition memory in epileptic patients, an effect assumed to be related to the activation of brainstem arousal systems. In this study, we applied non-invasive transcutaneous auricular VNS (tVNS) to replicate and extend the previous work. Using a single-blind, randomized, between-subject design, 60 healthy volunteers received active or sham stimulation during a lexical decision task, in which emotional and neutral stimuli were classified as words or non-words. In a subsequent recognition memory task (1 day after stimulation), participants' memory performance on these words and their subjective memory confidence were tested. Salivary alpha-amylase (sAA) levels, a putative indirect measure of central noradrenergic activation, were also measured before and after stimulation. During encoding, pleasant words were more accurately detected than neutral and unpleasant words. However, no tVNS effects were observed on task performance or on overall sAA level changes. tVNS also did not modulate overall recognition memory, which was particularly enhanced for pleasant emotional words. However, when hit rates were split based on confidence ratings reflecting familiarity- and recollection-based memory, higher recollection-based memory performance (irrespective of emotional category) was observed during active stimulation than during sham stimulation. To summarize, we replicated prior findings of enhanced processing and memory for emotional (pleasant) words. Whereas tVNS showed no effects on word processing, subtle effects on recollection-based memory performance emerged, which may indicate that tVNS facilitates hippocampus-mediated consolidation processes.}, language = {en} } @article{GiraudierVenturaBortWeymar2020, author = {Giraudier, Manon and Ventura-Bort, Carlos and Weymar, Mathias}, title = {Transcutaneous Vagus Nerve Stimulation (tVNS) Improves High-Confidence Recognition Memory but Not Emotional Word Processing}, series = {Frontiers in Psychology}, volume = {11}, journal = {Frontiers in Psychology}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1664-1078}, doi = {10.3389/fpsyg.2020.01276}, pages = {13}, year = {2020}, abstract = {Previous clinical research found that invasive vagus nerve stimulation (VNS) enhanced word recognition memory in epileptic patients, an effect assumed to be related to the activation of brainstem arousal systems. In this study, we applied non-invasive transcutaneous auricular VNS (tVNS) to replicate and extend the previous work. Using a single-blind, randomized, between-subject design, 60 healthy volunteers received active or sham stimulation during a lexical decision task, in which emotional and neutral stimuli were classified as words or non-words. In a subsequent recognition memory task (1 day after stimulation), participants' memory performance on these words and their subjective memory confidence were tested. Salivary alpha-amylase (sAA) levels, a putative indirect measure of central noradrenergic activation, were also measured before and after stimulation. During encoding, pleasant words were more accurately detected than neutral and unpleasant words. However, no tVNS effects were observed on task performance or on overall sAA level changes. tVNS also did not modulate overall recognition memory, which was particularly enhanced for pleasant emotional words. However, when hit rates were split based on confidence ratings reflecting familiarity- and recollection-based memory, higher recollection-based memory performance (irrespective of emotional category) was observed during active stimulation than during sham stimulation. To summarize, we replicated prior findings of enhanced processing and memory for emotional (pleasant) words. Whereas tVNS showed no effects on word processing, subtle effects on recollection-based memory performance emerged, which may indicate that tVNS facilitates hippocampus-mediated consolidation processes.}, language = {en} } @misc{GiraudierVenturaBortWendtetal.2022, author = {Giraudier, Manon and Ventura-Bort, Carlos and Wendt, Julia and Lischke, Alexander and Weymar, Mathias}, title = {Memory advantage for untrustworthy faces: Replication across lab- and web-based studies}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, issn = {1866-8364}, doi = {10.25932/publishup-56158}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-561586}, pages = {1 -- 11}, year = {2022}, abstract = {The Covid-19 pandemic imposed new constraints on empirical research and forced researchers to transfer from traditional laboratory research to the online environment. This study tested the validity of a web-based episodic memory paradigm by comparing participants' memory performance for trustworthy and untrustworthy facial stimuli in a supervised laboratory setting and an unsupervised web setting. Consistent with previous results, we observed enhanced episodic memory for untrustworthy compared to trustworthy faces. Most importantly, this memory bias was comparable in the online and the laboratory experiment, suggesting that web-based procedures are a promising tool for memory research.}, language = {en} } @article{GiraudierVenturaBortWendtetal.2022, author = {Giraudier, Manon and Ventura-Bort, Carlos and Wendt, Julia and Lischke, Alexander and Weymar, Mathias}, title = {Memory advantage for untrustworthy faces: Replication across lab- and web-based studies}, series = {PLoS ONE}, volume = {17}, journal = {PLoS ONE}, edition = {2}, publisher = {PLoS ONE}, address = {San Francisco, California, US}, issn = {1932-6203}, doi = {10.1371/journal.pone.0264034}, pages = {1 -- 11}, year = {2022}, abstract = {The Covid-19 pandemic imposed new constraints on empirical research and forced researchers to transfer from traditional laboratory research to the online environment. This study tested the validity of a web-based episodic memory paradigm by comparing participants' memory performance for trustworthy and untrustworthy facial stimuli in a supervised laboratory setting and an unsupervised web setting. Consistent with previous results, we observed enhanced episodic memory for untrustworthy compared to trustworthy faces. Most importantly, this memory bias was comparable in the online and the laboratory experiment, suggesting that web-based procedures are a promising tool for memory research.}, language = {en} } @article{GiraudierVenturaBortWeymar2020, author = {Giraudier, Manon and Ventura-Bort, Carlos and Weymar, Mathias}, title = {Effects of transcutaneous vagus nerve stimulation (TVNS) on emotional word processing and recognition memory}, series = {Psychophysiology}, volume = {57}, journal = {Psychophysiology}, publisher = {Wiley-Blackwell}, address = {Malden}, issn = {0048-5772}, pages = {S73 -- S73}, year = {2020}, language = {en} } @inproceedings{GiraudierVenturaBortWeymar2021, author = {Giraudier, Manon and Ventura-Bort, Carlos and Weymar, Mathias}, title = {A pooled preliminary analysis on the effects of transcutaneous auricular vagus nerve stimulation on salivary alpha-amylase as noradrenergic biomarker}, series = {Psychophysiology : journal of the Society for Psychophysiological Research}, volume = {58}, booktitle = {Psychophysiology : journal of the Society for Psychophysiological Research}, publisher = {Wiley-Blackwell}, address = {Malden, Mass. [u.a.]}, issn = {1469-8986}, pages = {S60 -- S60}, year = {2021}, language = {en} } @misc{GiraudierVenturaBortBurgeretal.2022, author = {Giraudier, Manon and Ventura-Bort, Carlos and Burger, Andreas M. and Claes, Nathalie and D'Agostini, Martina and Fischer, Rico and Franssen, Mathijs and Kaess, Michael and Koenig, Julian and Liepelt, Roman and Nieuwenhuis, Sander and Sommer, Aldo and Usichenko, Taras and Van Diest, Ilse and von Leupoldt, Andreas and Warren, Christopher Michael and Weymar, Mathias}, title = {Evidence for a modulating effect of transcutaneous auricular vagus nerve stimulation (taVNS) on salivary alpha-amylase as indirect noradrenergic marker: A pooled mega-analysis}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, number = {808}, issn = {1866-8364}, doi = {10.25932/publishup-57766}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-577668}, pages = {1378 -- 1388}, year = {2022}, abstract = {Background Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) has received tremendous attention as a potential neuromodulator of cognitive and affective functions, which likely exerts its effects via activation of the locus coeruleus-noradrenaline (LC-NA) system. Reliable effects of taVNS on markers of LC-NA system activity, however, have not been demonstrated yet. Methods The aim of the present study was to overcome previous limitations by pooling raw data from a large sample of ten taVNS studies (371 healthy participants) that collected salivary alpha-amylase (sAA) as a potential marker of central NA release. Results While a meta-analytic approach using summary statistics did not yield any significant effects, linear mixed model analyses showed that afferent stimulation of the vagus nerve via taVNS increased sAA levels compared to sham stimulation (b = 0.16, SE = 0.05, p = 0.001). When considering potential confounders of sAA, we further replicated previous findings on the diurnal trajectory of sAA activity. Conclusion(s) Vagal activation via taVNS increases sAA release compared to sham stimulation, which likely substantiates the assumption that taVNS triggers NA release. Moreover, our results highlight the benefits of data pooling and data sharing in order to allow stronger conclusions in research.}, language = {en} } @article{GiraudierVenturaBortBurgeretal.2022, author = {Giraudier, Manon and Ventura-Bort, Carlos and Burger, Andreas M. and Claes, Nathalie and D'Agostini, Martina and Fischer, Rico and Franssen, Mathijs and Kaess, Michael and Koenig, Julian and Liepelt, Roman and Nieuwenhuis, Sander and Sommer, Aldo and Usichenko, Taras and Van Diest, Ilse and von Leupoldt, Andreas and Warren, Christopher Michael and Weymar, Mathias}, title = {Evidence for a modulating effect of transcutaneous auricular vagus nerve stimulation (taVNS) on salivary alpha-amylase as indirect noradrenergic marker: A pooled mega-analysis}, series = {Brain Stimulation}, volume = {15}, journal = {Brain Stimulation}, edition = {6}, publisher = {Elsevier}, address = {New York, NY, USA}, issn = {1876-4754}, doi = {10.1016/j.brs.2022.09.009}, pages = {1378 -- 1388}, year = {2022}, abstract = {Background Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) has received tremendous attention as a potential neuromodulator of cognitive and affective functions, which likely exerts its effects via activation of the locus coeruleus-noradrenaline (LC-NA) system. Reliable effects of taVNS on markers of LC-NA system activity, however, have not been demonstrated yet. Methods The aim of the present study was to overcome previous limitations by pooling raw data from a large sample of ten taVNS studies (371 healthy participants) that collected salivary alpha-amylase (sAA) as a potential marker of central NA release. Results While a meta-analytic approach using summary statistics did not yield any significant effects, linear mixed model analyses showed that afferent stimulation of the vagus nerve via taVNS increased sAA levels compared to sham stimulation (b = 0.16, SE = 0.05, p = 0.001). When considering potential confounders of sAA, we further replicated previous findings on the diurnal trajectory of sAA activity. Conclusion(s) Vagal activation via taVNS increases sAA release compared to sham stimulation, which likely substantiates the assumption that taVNS triggers NA release. Moreover, our results highlight the benefits of data pooling and data sharing in order to allow stronger conclusions in research.}, language = {en} }