@article{WarschburgerCalvanoBeckeretal.2014, author = {Warschburger, Petra and Calvano, Claudia and Becker, Sebastian and Friedt, Michael and Hudert, Christian and Posovszky, Carsten and Schier, Maike and Wegscheider, Karl}, title = {Stop the pain: study protocol for a randomized-controlled trial}, series = {Trials}, volume = {15}, journal = {Trials}, publisher = {BioMed Central}, address = {London}, issn = {1745-6215}, doi = {10.1186/1745-6215-15-357}, pages = {11}, year = {2014}, abstract = {Background: Functional abdominal pain (FAP) is not only a highly prevalent disease but also poses a considerable burden on children and their families. Untreated, FAP is highly persistent until adulthood, also leading to an increased risk of psychiatric disorders. Intervention studies underscore the efficacy of cognitive behavioral treatment approaches but are limited in terms of sample size, long-term follow-up data, controls and inclusion of psychosocial outcome data. Methods/Design: In a multicenter randomized controlled trial, 112 children aged 7 to 12 years who fulfill the Rome III criteria for FAP will be allocated to an established cognitive behavioral training program for children with FAP (n = 56) or to an active control group (focusing on age-appropriate information delivery; n = 56). Randomization occurs centrally, blockwise and is stratified by center. This study is performed in five pediatric gastroenterology outpatient departments. Observer-blind assessments of outcome variables take place four times: pre-, post-, 3- and 12-months post-treatment. Primary outcome is the course of pain intensity and frequency. Secondary endpoints are health-related quality of life, pain-related coping and cognitions, as well as selfefficacy. Discussion: This confirmatory randomized controlled clinical trial evaluates the efficacy of a cognitive behavioral intervention for children with FAP. By applying an active control group, time and attention processes can be controlled, and long-term follow-up data over the course of one year can be explored.}, language = {en} } @article{WarschburgerHaenigFriedtetal.2014, author = {Warschburger, Petra and Haenig, Johanna and Friedt, Michael and Posovszky, Carsten and Schier, Maike and Calvano, Claudia}, title = {Health-Related quality of life in children with abdominal pain due to functional or organic gastrointestinal disorders}, series = {Journal of pediatric psychology}, volume = {39}, journal = {Journal of pediatric psychology}, number = {1}, publisher = {Oxford Univ. Press}, address = {Cary}, issn = {0146-8693}, doi = {10.1093/jpepsy/jst070}, pages = {45 -- 54}, year = {2014}, language = {en} } @misc{WarschburgerCalvanoRichteretal.2015, author = {Warschburger, Petra and Calvano, Claudia and Richter, Eike M. and Engbert, Ralf}, title = {Analysis of Attentional Bias towards Attractive and Unattractive Body Regions among Overweight Males and Females}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-86570}, year = {2015}, abstract = {Background Body image distortion is highly prevalent among overweight individuals. Whilst there is evidence that body-dissatisfied women and those suffering from disordered eating show a negative attentional bias towards their own unattractive body parts and others' attractive body parts, little is known about visual attention patterns in the area of obesity and with respect to males. Since eating disorders and obesity share common features in terms of distorted body image and body dissatisfaction, the aim of this study was to examine whether overweight men and women show a similar attentional bias. Methods/Design We analyzed eye movements in 30 overweight individuals (18 females) and 28 normalweight individuals (16 females) with respect to the participants' own pictures as well as gender- and BMI-matched control pictures (front and back view). Additionally, we assessed body image and disordered eating using validated questionnaires. Discussion The overweight sample rated their own body as less attractive and showed a more disturbed body image. Contrary to our assumptions, they focused significantly longer on attractive compared to unattractive regions of both their own and the control body. For one's own body, this was more pronounced for women. A higher weight status and more frequent body checking predicted attentional bias towards attractive body parts. We found that overweight adults exhibit an unexpected and stable pattern of selective attention, with a distinctive focus on their own attractive body regions despite higher levels of body dissatisfaction. This positive attentional bias may either be an indicator of a more pronounced pattern of attentional avoidance or a self-enhancing strategy. Further research is warranted to clarify these results.}, language = {en} } @article{WarschburgerCalvanoRichteretal.2015, author = {Warschburger, Petra and Calvano, Claudia and Richter, Eike M. and Engbert, Ralf}, title = {Analysis of Attentional Bias towards Attractive and Unattractive Body Regions among Overweight Males and Females}, series = {PLoS one}, journal = {PLoS one}, number = {10}, publisher = {Public Library of Science}, address = {Lawrence, Kan.}, issn = {1932-6203}, doi = {10.1371/journal.pone.0140813}, pages = {17}, year = {2015}, abstract = {Background Body image distortion is highly prevalent among overweight individuals. Whilst there is evidence that body-dissatisfied women and those suffering from disordered eating show a negative attentional bias towards their own unattractive body parts and others' attractive body parts, little is known about visual attention patterns in the area of obesity and with respect to males. Since eating disorders and obesity share common features in terms of distorted body image and body dissatisfaction, the aim of this study was to examine whether overweight men and women show a similar attentional bias. Methods/Design We analyzed eye movements in 30 overweight individuals (18 females) and 28 normalweight individuals (16 females) with respect to the participants' own pictures as well as gender- and BMI-matched control pictures (front and back view). Additionally, we assessed body image and disordered eating using validated questionnaires. Discussion The overweight sample rated their own body as less attractive and showed a more disturbed body image. Contrary to our assumptions, they focused significantly longer on attractive compared to unattractive regions of both their own and the control body. For one's own body, this was more pronounced for women. A higher weight status and more frequent body checking predicted attentional bias towards attractive body parts. We found that overweight adults exhibit an unexpected and stable pattern of selective attention, with a distinctive focus on their own attractive body regions despite higher levels of body dissatisfaction. This positive attentional bias may either be an indicator of a more pronounced pattern of attentional avoidance or a self-enhancing strategy. Further research is warranted to clarify these results.}, language = {en} } @article{WarschburgerCalvanoRichteretal.2015, author = {Warschburger, Petra and Calvano, Claudia and Richter, Eike M. and Engbert, Ralf}, title = {Analysis of Attentional Bias towards Attractive and Unattractive Body Regions among Overweight Males and Females: An Eye-Movement Study}, series = {PLoS one}, volume = {10}, journal = {PLoS one}, number = {10}, publisher = {PLoS}, address = {San Fransisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0140813}, pages = {17}, year = {2015}, abstract = {Background Body image distortion is highly prevalent among overweight individuals. Whilst there is evidence that body-dissatisfied women and those suffering from disordered eating show a negative attentional bias towards their own unattractive body parts and others' attractive body parts, little is known about visual attention patterns in the area of obesity and with respect to males. Since eating disorders and obesity share common features in terms of distorted body image and body dissatisfaction, the aim of this study was to examine whether overweight men and women show a similar attentional bias. Methods/Design We analyzed eye movements in 30 overweight individuals (18 females) and 28 normal-weight individuals (16 females) with respect to the participants' own pictures as well as gender- and BMI-matched control pictures (front and back view). Additionally, we assessed body image and disordered eating using validated questionnaires. Discussion The overweight sample rated their own body as less attractive and showed a more disturbed body image. Contrary to our assumptions, they focused significantly longer on attractive compared to unattractive regions of both their own and the control body. For one's own body, this was more pronounced for women. A higher weight status and more frequent body checking predicted attentional bias towards attractive body parts. We found that overweight adults exhibit an unexpected and stable pattern of selective attention, with a distinctive focus on their own attractive body regions despite higher levels of body dissatisfaction. This positive attentional bias may either be an indicator of a more pronounced pattern of attentional avoidance or a self-enhancing strategy. Further research is warranted to clarify these results.}, language = {en} } @article{CalvanoWarschburger2016, author = {Calvano, Claudia and Warschburger, Petra}, title = {Chronic Abdominal Pain in Children and Adolescents: Parental Threat Perception Plays a Major Role in Seeking Medical Consultations}, series = {Journal of the International Society of Sports Nutrition}, journal = {Journal of the International Society of Sports Nutrition}, publisher = {Hindawi Publishing Corp.}, address = {New York}, issn = {1203-6765}, doi = {10.1155/2016/3183562}, pages = {1 -- 10}, year = {2016}, abstract = {Background. Pain symptoms, associated impairment, and parental perception of threat are reported to be predictors of health care utilization (HCU) in childhood chronic abdominal pain (CAP). However, mediating variables and their interrelations have not yet been systematically studied. Objectives. This study aims to identify mediating pathways of influence between child's abdominal pain and the number of pain-related medical visits. Methods. In a multicenter study, we recruited N = 151 parent-child dyads with children aged 6-17 years suffering from CAP. A composite measure of pain symptoms was defined as predictor and the number of pain-related medical visits as outcome variable. This relation was analyzed by serial mediation, including child- and parent-reported impairment and parental threat perception as mediators. Results. Only parental threat perception significantly linked child's pain symptoms to the number of medical visits. Measures of impairment did not have a significant effect. Conclusions. Parental pain-related threat perception is strongly related to health care seeking in childhood CAP. Addressing threat perception might be a fruitful parent-centered approach in clinical practice.}, language = {en} } @misc{WarschburgerCalvanoBeckeretal.2017, author = {Warschburger, Petra and Calvano, Claudia and Becker, Sebastian and Friedt, Michael and Hudert, Christian and Posovszky, Carsten and Schier, Maike and Wegscheider, Karl}, title = {Stop the pain : study protocol for a randomized-controlled trial}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-401451}, pages = {11}, year = {2017}, abstract = {Background: Functional abdominal pain (FAP) is not only a highly prevalent disease but also poses a considerable burden on children and their families. Untreated, FAP is highly persistent until adulthood, also leading to an increased risk of psychiatric disorders. Intervention studies underscore the efficacy of cognitive behavioral treatment approaches but are limited in terms of sample size, long-term follow-up data, controls and inclusion of psychosocial outcome data. Methods/Design: In a multicenter randomized controlled trial, 112 children aged 7 to 12 years who fulfill the Rome III criteria for FAP will be allocated to an established cognitive behavioral training program for children with FAP (n = 56) or to an active control group (focusing on age-appropriate information delivery; n = 56). Randomization occurs centrally, blockwise and is stratified by center. This study is performed in five pediatric gastroenterology outpatient departments. Observer-blind assessments of outcome variables take place four times: pre-, post-, 3- and 12-months post-treatment. Primary outcome is the course of pain intensity and frequency. Secondary endpoints are health-related quality of life, pain-related coping and cognitions, as well as selfefficacy. Discussion: This confirmatory randomized controlled clinical trial evaluates the efficacy of a cognitive behavioral intervention for children with FAP. By applying an active control group, time and attention processes can be controlled, and long-term follow-up data over the course of one year can be explored.}, language = {en} } @article{CalvanoWarschburger2018, author = {Calvano, Claudia and Warschburger, Petra}, title = {Quality of life among parents seeking treatment for their child's functional abdominal pain}, series = {Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation}, volume = {27}, journal = {Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation}, number = {10}, publisher = {Springer}, address = {Dordrecht}, issn = {0962-9343}, doi = {10.1007/s11136-018-1916-2}, pages = {2557 -- 2570}, year = {2018}, abstract = {Purpose: Dealing with a child who suffers from functional abdominal pain (FAP) is a major challenge for the child's parents. However, little is known about the quality of life (QoL) of this group of parents. Therefore, this cross-sectional study aimed to provide a comprehensive analysis of parental QoL among parents seeking treatment for their child's abdominal pain. Methods: 133 parents of 7-13-year-old children diagnosed with FAP reported on their health-related QoL (HRQoL), as assessed by the SF-12, and on caregiver-related QoL, as assessed by two CHQ-PF50 scales (emotional impact, time impact). T tests were used to compare the parents' scores on these measures with reference scores. Subgroups which were at risk of impairment were defined by cut-off scores. Determinants of parental QoL were identified by hierarchical regression analyses. Results: While the parents showed significantly poorer mental health compared to population-based reference samples (d = 0.33-0.58), their physical health did not differ. However, parents were severely strained with respect to the time impact and emotional impact of their child's health (d = 0.33-1.58). While 12.7-27.9\% of the parents were at risk of poor HRQoL, 60.6-70.1\% were highly strained due to the demands of their role as caregivers. Physical and mental health were best explained by parents' psychiatric symptoms, while parents' perception of their child's impairment additionally determined the high time and emotional impact. Conclusions: Physical HRQoL is not impaired in the majority of parents seeking treatment for their child's functional abdominal pain. However, the time demands and worries due to the child's pain deserve specific attention. Psychosocial interventions for a child's FAP should include information provided to the parents about coping with time constraints and emotional impact. Further prospective studies are warranted.}, language = {en} } @phdthesis{Calvano2018, author = {Calvano, Claudia}, title = {Funktionelle Bauchschmerzen im Kindesalter}, school = {Universit{\"a}t Potsdam}, pages = {209}, year = {2018}, abstract = {Funktionelle Bauchschmerzen des Kindes betreffen die ganze Familie, wobei die Literatur insbesondere die Rolle der Eltern hervorhebt. Bisher wurden die Eltern jedoch prim{\"a}r als ā€˛critical behavioral agents" (Palermo \& Eccleston, 2009) gesehen, die einen Einfluss auf die Bauchschmerzen und Beeintr{\"a}chtigung des Kindes aus{\"u}ben. Untersuchungen der psychosozialen Auswirkungen der Bauchschmerzen und der Beeintr{\"a}chtigung des Kindes auf die Eltern wurden bislang vernachl{\"a}ssigt (Palermo \& Eccleston, 2009). Die Dissertation hatte daher zum Ziel, die Rolle der Eltern bei funktionellen Bauchschmerzen umfassend zu betrachten, indem sowohl schmerzbezogene Reaktionen der Eltern, als auch die psychosoziale Belastung der Eltern ber{\"u}cksichtigt und systematisch in Zusammenhang zu den Bauchschmerzen und der Beeintr{\"a}chtigung des Kindes untersucht wurden. Zum anderen sollten durch Interventionsstudien Aussagen {\"u}ber die Ver{\"a}nderbarkeit spezifischer Belastungsmerkmale der Eltern und {\"u}ber das Wechselspiel zwischen der Ebene der Eltern und der Ebene des Kindes erm{\"o}glicht werden. Anhand von vier Studien sollten die Fragen beantworten werden 1) welche Faktoren die {\"a}rztliche Inanspruchnahme beeinflussen und welche besondere Relevanz dabei die Bewertungsprozesse der Eltern besitzen, 2) wie die psychosoziale Belastung der Eltern charakterisiert ist und durch welche Faktoren sie beeinflusst wird, 3) welche Ver{\"a}nderungen im Rahmen einer kindzentrierten verhaltenstherapeutischen Intervention auf Seiten der Eltern zu beobachten sind und 4) wie sich diese Ver{\"a}nderungen seitens der Eltern und seitens des Kindes gegenseitig beeinflussen.}, language = {de} } @article{PosovszkyRoeslerBeckeretal.2019, author = {Posovszky, Carsten and Roesler, Vreni Helen and Becker, Sebastian and Iven, Enno and Hudert, Christian and Ebinger, Friedrich and Calvano, Claudia and Warschburger, Petra}, title = {Roles of Lactose and Fructose Malabsorption and Dietary Outcomes in Children Presenting with Chronic Abdominal Pain}, series = {Nutrients}, volume = {11}, journal = {Nutrients}, number = {12}, publisher = {MDPI}, address = {Basel}, issn = {2072-6643}, doi = {10.3390/nu11123063}, pages = {13}, year = {2019}, abstract = {Intolerance to lactose or fructose is frequently diagnosed in children with chronic abdominal pain (CAP). However, the causal relationship remains a matter of discussion. A cohort of 253 patients, aged 7-12 years, presenting with unexplained CAP received standardized diagnostics. Additional diagnostic tests were performed based on their medical history and physical and laboratory investigations. Fructose and lactose hydrogen breath tests (H2BT) as well as empiric diagnostic elimination diets were performed in 135 patients reporting abdominal pain related to the consumption of lactose or fructose to evaluate carbohydrate intolerance as a potential cause of CAP. Carbohydrate malabsorption by H2BT was found in 55 (41\%) out of 135 patients. An abnormal increase in H2BT was revealed in 30\% (35/118) of patients after fructose consumption and in 18\% (20/114) of patients after lactose administration. Forty-six percent (25/54) reported pain relief during a diagnostic elimination diet. In total, 17 patients had lactose malabsorption, 29 fructose malabsorption, and nine combined carbohydrate malabsorption. Carbohydrate intolerance as a cause of CAP was diagnosed at follow-up in only 18\% (10/55) of patients with malabsorption after the elimination of the respective carbohydrate. Thus, carbohydrate malabsorption appears to be an incidental finding in children with functional abdominal pain disorders, rather than its cause. Therefore, testing of carbohydrate intolerance should only be considered in children with a strong clinical suspicion and with the goal to prevent long-term unnecessary dietary restrictions in children suffering from CAP.}, language = {en} } @article{CalvanoWarschburger2022, author = {Calvano, Claudia and Warschburger, Petra}, title = {Treatment for pediatric functional abdominal pain}, series = {Journal of pediatric psychology}, volume = {47}, journal = {Journal of pediatric psychology}, number = {4}, publisher = {Oxford Univ. Press}, address = {Oxford}, issn = {0146-8693}, doi = {10.1093/jpepsy/jsac011}, pages = {483 -- 496}, year = {2022}, abstract = {Objective While cross-sectional studies underline that child and parent factors in pediatric chronic pain are reciprocally related, so far, little is known on their prospective relationship, especially in treatment contexts. This study aims to analyze directions of influence between child and parental outcomes using data from an intervention study. Methods The sample covered 109 families with children aged 7-13 years diagnosed with functional abdominal pain (FAP). Child outcomes included pain and impairment, and parental outcomes covered caregiver-specific distress including both parental personal time burden (i.e., less time available for personal needs) and emotional burden due to child's pain (i.e., increased worries). Cross-lagged panel analyses examined the directions of the relations between child and parental outcomes across time (pretreatment T1, post-treatment T2, and 3-month follow-up and 12-month follow-up T3/T4). Results First, a significant improvement over time in all measures was observed. Cross-lagged effects were found for less parental personal time burden at T2, predicting both less pain (beta = -0.254, p = .004) and less impairment (beta = -0.150, p = .039) at T3. Higher baseline pain was predictive for higher parental emotional burden after treatment (beta = -0.130, p = .049) and, reversely, for less emotional burden at 12-month follow-up (beta = 0.261, p = .004). Conclusions Addressing parental personal time burden in FAP treatment might possibly support the improvement on the child level. Replication of results in larger samples is warranted to gain more insight into the directions of influence and, in that way, to optimize treatment for pediatric FAP.}, language = {en} }