@misc{GaertnerSteinfathAndorfetal.2009, author = {G{\"a}rtner, Tanja and Steinfath, Matthias and Andorf, Sandra and Lisec, Jan and Meyer, Rhonda C. and Altmann, Thomas and Willmitzer, Lothar and Selbig, Joachim}, title = {Improved heterosis prediction by combining information on DNA- and metabolic markers}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-45132}, year = {2009}, abstract = {Background: Hybrids represent a cornerstone in the success story of breeding programs. The fundamental principle underlying this success is the phenomenon of hybrid vigour, or heterosis. It describes an advantage of the offspring as compared to the two parental lines with respect to parameters such as growth and resistance against abiotic or biotic stress. Dominance, overdominance or epistasis based models are commonly used explanations. Conclusion/Significance: The heterosis level is clearly a function of the combination of the parents used for offspring production. This results in a major challenge for plant breeders, as usually several thousand combinations of parents have to be tested for identifying the best combinations. Thus, any approach to reliably predict heterosis levels based on properties of the parental lines would be highly beneficial for plant breeding. Methodology/Principal Findings: Recently, genetic data have been used to predict heterosis. Here we show that a combination of parental genetic and metabolic markers, identified via feature selection and minimum-description-length based regression methods, significantly improves the prediction of biomass heterosis in resulting offspring. These findings will help furthering our understanding of the molecular basis of heterosis, revealing, for instance, the presence of nonlinear genotype-phenotype relationships. In addition, we describe a possible approach for accelerated selection in plant breeding.}, language = {en} } @misc{SteinfathGaertnerLisecetal.2009, author = {Steinfath, Matthias and G{\"a}rtner, Tanja and Lisec, Jan and Meyer, Rhonda C. and Altmann, Thomas and Willmitzer, Lothar and Selbig, Joachim}, title = {Prediction of hybrid biomass in Arabidopsis thaliana by selected parental SNP and metabolic markers}, series = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Zweitver{\"o}ffentlichungen der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {1324}, issn = {1866-8372}, doi = {10.25932/publishup-43111}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431115}, pages = {9}, year = {2009}, abstract = {A recombinant inbred line (RIL) population, derived from two Arabidopsis thaliana accessions, and the corresponding testcrosses with these two original accessions were used for the development and validation of machine learning models to predict the biomass of hybrids. Genetic and metabolic information of the RILs served as predictors. Feature selection reduced the number of variables (genetic and metabolic markers) in the models by more than 80\% without impairing the predictive power. Thus, potential biomarkers have been revealed. Metabolites were shown to bear information on inherited macroscopic phenotypes. This proof of concept could be interesting for breeders. The example population exhibits substantial mid-parent biomass heterosis. The results of feature selection could therefore be used to shed light on the origin of heterosis. In this respect, mainly dominance effects were detected.}, language = {en} } @book{Behrmann2009, author = {Behrmann, G{\"u}nter C.}, title = {Skepsis und Engagement : Arbeiten zur Bildungsgeschichte und Lehrerbildung}, editor = {Albrecht, Clemens and Lohwaßer, Roswitha and Naumann, Rosemarie}, publisher = {Universit{\"a}tsverlag Potsdam}, address = {Potsdam}, isbn = {978-3-940793-62-1}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-27594}, publisher = {Universit{\"a}t Potsdam}, pages = {221}, year = {2009}, abstract = {Im Februar 2009 endet die Lehr- und Forschungst{\"a}tigkeit von G{\"u}nter C. Behrmann an der Universit{\"a}t Potsdam. Anl{\"a}sslich seiner Emeritierung gibt das Zentrum f{\"u}r Lehrerbildung der Universit{\"a}t ausgew{\"a}hlte Aufs{\"a}tze, die G{\"u}nter C. Behrmann w{\"a}hrend seiner Potsdamer Zeit publiziert hat, heraus. Diese Aufs{\"a}tze spiegeln seine Lehr- und Forschungsinteressen sowie sein Engagement in der universit{\"a}ren Selbstverwaltung, sie zeigen die Verbindung zwischen der Deutung einer historischen Lage und den Folgerungen, die Behrmann f{\"u}r die L{\"o}sung praktischer politisch-p{\"a}dagogischer Probleme aus dieser Deutung erschloss. Lebenslauf und Schriftenverzeichnis erg{\"a}nzen die Festschrift und {\"o}ffnen den Blick f{\"u}r das Wirken und das wissenschaftliche Werk G{\"u}nter C. Behrmanns in seiner Gesamtheit.}, language = {de} } @misc{PeterYenesewTwinomuhwezietal.2009, author = {Peter, Martin G. and Yenesew, Abiy and Twinomuhwezi, Hannington and Kabaru, Jacques M. and Akala, Hoseah M. and Kiremire, Bernard T. and Heydenreich, Matthias and Eyase, Fredrick and Waters, Norman C. and Walsh, Douglas S.}, title = {Antiplasmodial and larvicidal flavonoids from Derris trifoliata}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-44614}, year = {2009}, abstract = {From the dichloromethane-methanol (1:1) extract of the seed pods of Derris trifoliata, a new flavanone derivative (S)-lupinifolin 4´-methyl ether was isolated. In addition, the known flavonoids lupinifolin and rotenone were identified. The structures were determined on the basis of spectroscopic evidence. Lupinfolin showed moderate in vitro antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquineresistant) strains of Plasmodium falciparum. The different parts of this plant showed larvicidal activities against Aedes aegypti and rotenoids were identified as the active principles.}, language = {en} } @misc{PeterMuivaYenesewetal.2009, author = {Peter, Martin G. and Muiva, Lois M. and Yenesew, Abiy and Derese, Solomon and Heydenreich, Matthias and Akala, Hoseah M. and Eyase, Fredrick and Waters, Norman C. and Mutai, Charles and Keriko, Joseph M. and Walsh, Douglas S.}, title = {Antiplasmodial β-hydroxydihydrochalcone from seedpods of Tephrosia elata}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-44437}, year = {2009}, abstract = {From the seedpods of Tephrosia elata, a new β-hydroxydihydrochalcone named (S)-elatadihydrochalcone was isolated. In addition, the known flavonoids obovatachalcone, obovatin, obovatin methyl ether and deguelin were identified. The structures were determined on the basis of spectroscopic evidence. The crude extract and the flavonoids obtained from the seedpods of this plant showed antiplasmodial activities. The literature NMR data on β-hydroxydihydrochalcones is reviewed and the identity of some of the compounds assigned β-hydroxydihydrochalcone skeleton is questioned.}, language = {en} } @misc{Tristram2009, author = {Tristram, Hildegard L.C.}, title = {Wie weit sind die inselkeltischen Sprachen (und das Englische) analytisiert?}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-41251}, year = {2009}, abstract = {Der gemeinsame Wandel der inselkeltischen Sprachen wie auch des Englischen vom vorwiegend synthetischen Typus zum vorwiegend analytischen Typus l{\"a}ßt sich vermutlich auf einen ca. 1500 Jahre dauernden intensiven Sprachenkontakt zwischen diesen Sprachen zur{\"u}ckf{\"u}hren. Heute ist das Englische die analytischste Sprache der Britischen Inseln und Irlands, gefolgt vom Walisischen, Bretonischen und Irischen. Letzteres ist von den genannten Sprachen noch am weitesten morphologisch komplex.}, language = {de} }