@phdthesis{Kaneza2024,
  author    = {Kaneza, Elisabeth},
  title     = {Rassische Diskriminierung in Deutschland},
  series = {Schriften des MenschenRechtsZentrums der Universit{\"a}t Potsdam},
  volume    = {49},
  journal   = {Schriften des MenschenRechtsZentrums der Universit{\"a}t Potsdam},
  publisher = {Nomos},
  address   = {Baden-Baden},
  isbn      = {978-3-7560-1461-3},
  doi       = {10.5771/9783748919988},
  school      = {Universit{\"a}t Potsdam},
  pages     = {417},
  year      = {2024},
  abstract  = {Diese Arbeit zeigt auf, wie historisch und rechtlich eine Ungleichheit zwischen Schwarzen und Weißen in Deutschland gewachsen ist und geht der Frage nach, welche Anforderungen das Verfassungsrecht, die Rechtspraxis und die Politik erf{\"u}llen m{\"u}ssen, um sie auszugleichen. Eingangs wird die Entwicklung des Verbots der rassischen Diskriminierung im internationalen und nationalen Recht dargelegt. Folglich zeichnet die Verfasserin die Diskriminierungsgeschichte von Schwarzen Menschen nach. Zur {\"U}berwindung der nach wie vor bestehenden strukturellen Diskriminierung schl{\"a}gt sie ein positives Recht vor, das sich auf Menschenrechtsstandards und L{\"o}sungsans{\"a}tzen aus Rechtsvergleichen st{\"u}tzt und die Gleichberechtigung von Schwarzen Menschen bewirken soll.},
  language  = {de}
}
@phdthesis{Grohmann2024,
  author    = {Grohmann, Nils-Hendrik},
  title     = {Strengthening the UN Human Rights Treaty Bodies},
  series = {Jus Internationale et Europaeum},
  journal   = {Jus Internationale et Europaeum},
  number    = {202},
  publisher = {Mohr Siebeck},
  address   = {T{\"u}bingen},
  isbn      = {978-3-16-162825-2},
  issn      = {1861-1893},
  doi       = {10.1628/978-3-16-162826-9},
  pages     = {XV, 315},
  year      = {2024},
  abstract  = {Nils-Hendrik Grohmann besch{\"a}ftigt sich mit dem noch andauernden St{\"a}rkungsprozess der UN-Menschenrechtsvertragsorgane. Er analysiert, welche rechtlichen Befugnisse die Aussch{\"u}sse haben, ob sie von sich aus Vorschl{\"a}ge einbringen k{\"o}nnen und inwieweit sie ihre Verfahrensweisen bisher aufeinander abgestimmt haben. Ein weiterer Schwerpunkt liegt auf der Zusammenarbeit zwischen den verschiedenen Aussch{\"u}ssen und der Frage, welche Rolle das Treffen der Vorsitzenden bei der St{\"a}rkung spielen kann.},
  language  = {en}
}
@phdthesis{Tomović2024,
  author    = {Tomović, Jelena},
  title     = {Sexualit{\"a}t in der Geschichte},
  series = {Schriften des Fr{\"u}hneuzeitzentrums Potsdam},
  volume    = {12},
  journal   = {Schriften des Fr{\"u}hneuzeitzentrums Potsdam},
  publisher = {V\&R unipress - Brill Deutschland GmbH},
  address   = {G{\"o}ttingen},
  isbn      = {978-3-8471-1686-8},
  issn      = {2198-5251},
  doi       = {10.14220/9783737016865},
  school      = {Universit{\"a}t Potsdam},
  pages     = {336},
  year      = {2024},
  abstract  = {Jelena Tomović f{\"u}hrt in diesem Band durch die Entwicklungen unserer sexuellen Sprache und Praktiken. Sie zeigt, dass die Art und Weise, wie {\"u}ber Sexualit{\"a}t gesprochen wird, nicht nur ein Spiegelbild, sondern auch ein treibender Faktor f{\"u}r soziale Ver{\"a}nderungen ist. Die Studie stellt die konventionelle Vorstellung von Sexualit{\"a}t in Frage und f{\"u}hrt die Lesenden in eine Welt der subtilen Nuancen und kulturellen Ver{\"a}nderungen. Mit kommunikationstheoretischen Ans{\"a}tzen, dem praxeologischen Ansatz, ihrer sozialkonstruktivistischen Grundannahme und einem klaren Fokus auf Akteur*innen bietet die Autorin eine frische Perspektive auf die Geschichte der Sexualit{\"a}t. Das Buch er{\"o}ffnet neue Wege f{\"u}r die Erforschung und das Verst{\"a}ndnis von Intimit{\"a}t und sozialer Kommunikation.},
  language  = {de}
}
@phdthesis{Henning2024,
  author    = {Henning, Thorsten},
  title     = {Cross-sectional associations of dietary biomarker patterns with health and nutritional status},
  school      = {Universit{\"a}t Potsdam},
  pages     = {111},
  year      = {2024},
  language  = {en}
}
@phdthesis{Martin2024,
  author    = {Martin, Katja},
  title     = {Beerdigen oder verbrennen?},
  publisher = {arijeh-verlag},
  address   = {Potsdam},
  isbn      = {978-3-944693-04-0},
  school      = {Universit{\"a}t Potsdam},
  pages     = {398},
  year      = {2024},
  language  = {de}
}
@phdthesis{Kersting2024,
  author    = {Kersting, Katerina},
  title     = {Development of a CRISPR/Cas gene editing technique for the coccolithophore Chrysotila carterae},
  school      = {Universit{\"a}t Potsdam},
  pages     = {137},
  year      = {2024},
  language  = {en}
}
@phdthesis{Stechemesser2023,
  author    = {Stechemesser, Annika},
  title     = {Human behaviour in a warming world},
  school      = {Universit{\"a}t Potsdam},
  pages     = {339},
  year      = {2023},
  language  = {en}
}
@phdthesis{Rehtmeyer2024,
  author    = {Rehtmeyer, Marcus},
  title     = {Die Staatskirchenvertr{\"a}ge Preußens 1929 und 1931},
  series = {Rechtsgeschichtliche Forschungen},
  volume    = {4},
  journal   = {Rechtsgeschichtliche Forschungen},
  publisher = {Nomos},
  address   = {Baden-Baden},
  isbn      = {978-3-7560-1369-2},
  school      = {Universit{\"a}t Potsdam},
  pages     = {734},
  year      = {2024},
  abstract  = {Die umfangreiche rechtswissenschaftliche Studie befasst sich mit den preußischen Staatskirchenvertr{\"a}gen aus der Zeit der Weimarer Republik. Diese Vertr{\"a}ge waren H{\"o}hepunkte einer Entwicklung in Richtung gr{\"o}ßerer Freiheit und Unabh{\"a}ngigkeit der Kirchen vom Staat, die den Vorg{\"a}ngen im Reich und in anderen deutschen L{\"a}ndern teils entsprach, teils zuwiderlief. Die Entwicklung folgte keiner unverr{\"u}ckbaren Idealvorstellung {\"u}ber das Verh{\"a}ltnis von Staat und Kirche, sondern stellte sich stets als pragmatische Reaktion auf realpolitische Probleme dar. Die Staatskirchenvertr{\"a}ge selbst pr{\"a}gten die weiteren Entwicklungen in Ost und West bis zur Gegenwart.},
  language  = {de}
}
@phdthesis{You2024,
  author    = {You, Lili},
  title     = {Chloroplast engineering for recombinant protein production and stress protection},
  school      = {Universit{\"a}t Potsdam},
  pages     = {133},
  year      = {2024},
  language  = {en}
}
@phdthesis{Szekely2024,
  author    = {Sz{\´e}kely, Andr{\´a}s Csaba},
  title     = {Long-distance circadian coordination via a phloem-delivered mobile transcript},
  school      = {Universit{\"a}t Potsdam},
  pages     = {105},
  year      = {2024},
  language  = {en}
}
@phdthesis{Melliger2024,
  author    = {Melliger, Marc Andr{\´e}},
  title     = {Effects of exposing renewables to the market},
  school      = {Universit{\"a}t Potsdam},
  pages     = {xi, 139},
  year      = {2024},
  abstract  = {Electricity production contributes to a significant share of greenhouse gas emissions in Europe and is thus an important driver of climate change. To fulfil the Paris Agreement, the European Union (EU) needs a rapid transition to a fully decarbonised power production system. Presumably, such a system will be largely based on renewables. So far, many EU countries have supported a shift towards renewables such as solar and wind power using support schemes, but the economic and political context is changing. Renewables are now cheaper than ever before and have become cost-competitive with conventional technologies. Therefore, European policymakers are striving to better integrate renewables into a competitive market and to increase the cost-effectiveness of the expansion of renewables. The first step was to replace previous fixed-price schemes with competitive auctions. In a second step, these auctions have become more technology-open. Finally, some governments may phase out any support for renewables and fully expose them to the competitive power market. However, such policy changes may be at odds with the need to rapidly expand renewables and meet national targets due to market characteristics and investors' risk perception. Without support, price risks are higher, and it may be difficult to meet an investor's income expectations. Furthermore, policy changes across different countries could have unexpected effects if power markets are interconnected and investors able to shift their investments. Finally, in multi-technology auctions, technologies may dominate, which can be a risk for long-term power system reliability. Therefore, in my thesis, I explore the effects of phasing out support policies for renewables, of coordinating these phase-outs across countries, and of using multi-technology designs. I expand the public policy literature about investment behaviour and policy design as well as policy change and coordination, and I further develop an agent-based model. The main questions of my thesis are what the cost and deployment effects of gradually exposing renewables to market forces would be and how coordination between countries affects investors' decisions and market prices.. In my three contributions to the academic literature, I use different methods and come to the following results. In the first contribution, I use a conjoint analysis and market simulation to evaluate the effects of phasing out support or reintroducing feed-in tariffs from the perspective of investors. I find that a phase-out leads to investment shifts, either to other still-supported technologies or to other countries that continue to offer support. I conclude that the coordination of policy changes avoids such shifts.. In the second contribution, I integrate the empirically-derived preferences from the first contribution in to an agent-based power system model of two countries to simulate the effects of ending auctions for renewables. I find that this slows the energy transition, and that cross-border effects are relevant. Consequently, continued support is necessary to meet the national renewables targets. In the third contribution, I analyse the outcome of past multi-technology auctions using descriptive statistics, regression analysis as well as case study comparisons. I find that the outcomes are skewed towards single technologies. This cannot be explained by individual design elements of the auctions, but rather results from context-specific and country-specific characteristics. Based on this, I discuss potential implications for long-term power system reliability. The main conclusions of my thesis are that a complete phase-out of renewables support would slow down the energy transition and thus jeopardize climate targets, and that multi-technology auctions may pose a risk for some countries, especially those that cannot regulate an unbalanced power plant portfolio in the long term. If policymakers decide to continue supporting renewables, they may consider adopting technology-specific auctions to better steer their portfolio. In contrast, if policymakers still want to phase out support, they should coordinate these policy changes with other countries. Otherwise, overall transition costs can be higher, because investment decisions shift to still-supported but more expensive technologies.},
  language  = {en}
}
@phdthesis{Streitboerger2024,
  author    = {Streitb{\"o}rger, Chiara},
  title     = {Preisalgorithmenkartelle},
  series = {Datenrecht und neue Technologien},
  volume    = {9},
  journal   = {Datenrecht und neue Technologien},
  publisher = {Nomos},
  address   = {Baden-Baden},
  isbn      = {978-3-7560-0838-4},
  school      = {Universit{\"a}t Potsdam},
  pages     = {325},
  year      = {2024},
  abstract  = {Mithilfe von Preisalgorithmen sind Unternehmen in der Lage, automatische und wechselseitige Preisanpassungen vorzunehmen. Dadurch k{\"o}nnen klassische Kartellkonstellationen mangels konspirativer Treffen in den Hintergrund treten. Die Arbeit zeigt auf, unter welchen Voraussetzungen der Einsatz von Preisalgorithmen einen Verstoß gegen das europ{\"a}ische Kartellverbot begr{\"u}nden kann. Dazu werden Fallkonstellationen beleuchtet, die ein algorithmisches Zusammenwirken sowohl unmittelbar zwischen Wettbewerbern als auch mittelbar {\"u}ber einen Dritten begr{\"u}nden. Ferner wird auch auf algorithmenspezifische Compliance-Maßnahmen eingegangen. Schließlich werden die praktischen Herausforderungen bei der Aufdeckung und dem Nachweis solcher Kartelle aufgezeigt.},
  language  = {de}
}
@phdthesis{Schmidt2023,
  author    = {Schmidt, Christian},
  title     = {Vom Trauma zum bedeutungsvollen Ersterlebnis},
  publisher = {Karl Alber},
  address   = {Baden-Baden},
  isbn      = {978-3-4959-9450-4},
  doi       = {10.5771/9783495994511},
  pages     = {342},
  year      = {2023},
  abstract  = {Ausgehend von {\"U}berlegungen des anthropologisch orientierten Psychiaters Erwin Straus geht dieses Buch der Frage nach, welche Bedingungen vorliegen, wenn bestimmte Ereignisse von Personen als bedeutsam erlebt werden. Des Weiteren wird ausf{\"u}hrlich er{\"o}rtert, wie sich Personalit{\"a}t im Menschen ausbildet und inwieweit sie von der gelingenden Integration bedeutungsvoller Ersterlebnisse abh{\"a}ngt. Das dabei zugrundeliegende Person-Konzept stellt einen eigenst{\"a}ndigen Syntheseversuch der vier Konzepte von Erwin Straus, Viktor Emil von Gebsattel, Helmuth Plessner und Max Scheler dar. Der Autor arbeitet in ober{\"a}rztlicher Funktion am Klinikum Schloss L{\"u}tgenhof in Dassow, einer Akutklinik f{\"u}r Personale Medizin, integrierte Psychosomatik, Innere Medizin und Psychotherapie},
  language  = {de}
}
@phdthesis{Wojciechowska2022,
  author    = {Wojciechowska, Izabela},
  title     = {The journey towards the discovery of new protein-metabolite interactions in Arabidopsis thaliana and further functional characterization of selected binding events},
  school      = {Universit{\"a}t Potsdam},
  pages     = {150},
  year      = {2022},
  language  = {en}
}
@phdthesis{Kappel2023,
  author    = {Kappel, Sandrine},
  title     = {Photosynthesis in fluctuating light},
  school      = {Universit{\"a}t Potsdam},
  pages     = {172},
  year      = {2023},
  abstract  = {Light is the essential energy source for plants to drive photosynthesis. In nature, light availability is highly variable and often fluctuates on very short time scales. As a result, plants developed mechanisms to cope with these fluctuations. Understanding how to improve light use efficiency in natural fluctuating light (FL) conditions is a major target for agronomy. In the first project, we identified an Arabidopsis thaliana plant that showed reduced levels of rapidly inducible non-photochemical quenching (NPQ). This plant was devoid of any T-DNA insertion. Using a mapping-by-sequencing approach, we successfully located the causal genomic region near the end of chromosome 4. Through variant investigations in that region, we identified a deletion of about 20 kb encompassing 9 genes. By complementation analysis, we confirmed that one of the deleted genes, VTC2, is the causal gene responsible for the low NPQ. Loss of VTC2 decreased NPQ particularly in old leaves, with young leaves being only slightly affected. Additionally, ascorbate levels were almost abolished in old leaves, likely causing the NPQ decrease by reducing the activity of the xanthophyll cycle. Although ascorbate levels in younger leaves were reduced compared to wild-type plants, they remained at a comparably higher level. This difference may be due to the VTC2 paralog VTC5, which is expressed at a higher level in young leaves than in old ones. Plants require the PROTON GRADIENT REGULATION 5 (PGR5) protein for survival in FL. pgr5 mutants die because they fail to increase the luminal proton concentration in response to high light (HL) phases. A rapid elevation in ∆pH is needed to slow down electron transport through the Cytochrome b6 f complex (photosynthetic control). In FL, such lack of control in the pgr5 mutants results in photosystem I (PSI) overreduction, reactive oxygen species (ROS) production, and cell death. Decreases in photosystem II (PSII) activity introduced by crossing pgr5 with PSII deficient mutants rescued the lethality of pgr5 in FL. PGR5 was suggested to act as part of the ferredoxin-plastoquinone reductase (FQR), involved in cyclic electron transfer around PSI. However, the proposed molecular role of PGR5 remains highly debated. To learn more about PGR5 function, we performed a forward genetic screen in Arabidopsis thaliana to identify EMS-induced suppressor mutants surviving longer when grown in FL compared to pgr5 mutants (referred to as "suppressor of pgr5 lethality in fluctuating light", splf ). 11 different candidate genes were identified in a total of 22 splf plants. Mutants of seven of these genes in the pgr5 background showed low Fv/Fm values when grown in non-fluctuating low light (LL). Five of these 4genes were previously reported to have a role in PSII biogenesis or function. Two others, RPH1 and a DEAD/DEAH box helicase (AT3G02060), have not been linked to PSII function before. Three of splf candidate genes link to primary metabolism, fructose-2,6-bisphosphatase (F2KP ), udp-glucose pyrophosphorylase 1 (UGP1 ) and ferredoxin-dependent glutamate synthase (Fd-GOGAT ). They are characterized by the fact that they survive longer in FL than pgr5 mutants but do not procede beyond the early vegetative phase and then die.},
  language  = {en}
}
@phdthesis{Bulut2023,
  author    = {Bulut, Mustafa},
  title     = {Assessing the genetic architecture underlying systemic responses to variable environments in crops using multi-omics},
  school      = {Universit{\"a}t Potsdam},
  pages     = {180, IV},
  year      = {2023},
  abstract  = {Plant metabolism serves as the primary mechanism for converting assimilated carbon into essential compounds crucial for plant growth and ultimately, crop yield. This renders it a focal point of research with significant implications. Despite notable strides in comprehending the genetic principles underpinning metabolism and yield, there remains a dearth of knowledge regarding the genetic factors responsible for trait variation under varying environmental conditions. Given the burgeoning global population and the advancing challenges posed by climate change, unraveling the intricacies of metabolic and yield responses to water scarcity became increasingly important in safeguarding food security. Our research group has recently started to work on the genetic resources of legume species. To this end, the study presented here investigates the metabolic diversity across five different legume species at a tissue level, identifying species-specific biosynthesis of alkaloids as well as iso-/flavonoids with diverse functional groups, namely prenylation, phenylacylation as well as methoxylation, to create a resource for follow up studies investigation the metabolic diversity in natural diverse populations of legume species. Following this, the second study investigates the genetic architecture of drought-induced changes in a global common bean population. Here, a plethora of quantitative trait loci (QTL) associated with various traits are identified by performing genome-wide association studies (GWAS), including for lipid signaling. On this site, overexpression of candidates highlighted the induction of several oxylipins reported to be pivotal in coping with harsh environmental conditions such as water scarcity. Diverging from the common bean and GWAS, the following study focuses on identifying drought-related QTL in tomato using a bi-parental breeding population. This descriptive study highlights novel multi-omic QTL, including metabolism, photosynthesis as well as fruit setting, some of which are uniquely assigned under drought. Compared to conventional approaches using the bi-parental IL population, the study presented improves the resolution by assessing further backcrossed ILs, named sub-ILs. In the final study, a photosynthetic gene, namely a PetM subunit of the cytochrome b6f complex encoding gene, involved in electron flow is characterized in an horticultural important crop. While several advances have been made in model organisms, this study highlights the transition of this fundamental knowledge to horticultural important crops, such as tomato, and investigates its function under differing light conditions. Overall, the presented thesis combines different strategies in unveiling the genetic components in multi-omic traits under drought using conventional breeding populations as well as a diverse global population. To this end, it allows a comparison of either approach and highlights their strengths and weaknesses.},
  language  = {en}
}
@phdthesis{Kern2023,
  author    = {Kern, Anne},
  title     = {Juana Borrero},
  series = {Mimesis},
  volume    = {93},
  journal   = {Mimesis},
  publisher = {De Gruyter},
  address   = {Berlin},
  isbn      = {978-3-11-074835-2},
  issn      = {0178-7489},
  doi       = {10.1515/9783110748499},
  school      = {Universit{\"a}t Potsdam},
  pages     = {XIII, 602},
  year      = {2023},
  abstract  = {Juana Borrero y Pierra (1877-1896) war eine der wichtigsten Vertreterinnen des inselkubanischen Modernismo. Gleichwohl ist das Schaffen der schon zu Lebzeiten zum Wunderkind stilisierten Autorin, Dichterin und Malerin wissenschaftlich kaum eingehender untersucht worden. Die Werkstudie schl{\"a}gt einen umfassenden, konsequent {\"a}sthetischen Blick auf das aus Gedichten, poetischer Prosa, literarischen Liebesbriefen, Zeichnungen und Malereien bestehende Gesamtwerk Borreros vor, das im Kern ein Streben nach Ganzheit von Kunst und Leben offenlegt. Dabei werden die Text- und Bildstrategien der K{\"u}nstlerin mit den {\"a}sthetischen, soziohistorischen und biografischen Kontexten verzahnt, wodurch Juana Borreros Stimme als exemplarische Stimme der kubanischen Sp{\"a}tmoderne sowie einer bewegten kubanischen Literatur les- und sichtbar wird.},
  language  = {de}
}
@phdthesis{Maul2023,
  author    = {Maul, Valeska Joya},
  title     = {Addressing current challenges of ecosystems in innovation and entrepreneuership},
  school      = {Universit{\"a}t Potsdam},
  pages     = {176, XX},
  year      = {2023},
  abstract  = {Nowadays, innovative and entrepreneurial activities and their actors are embedded in interdependent systems to drive joint value creation. Innovation ecosystems and entrepreneurial ecosystems have become established system-level concepts in management research to explain how value transpires between different actors and institutions in distinct contexts. Despite the popularity of the concepts, researchers have critiqued their theoretical depth, conceptual distinctiveness, as well as operationalization and measurement (Autio \& Thomas, 2022; Klimas \& Czakon, 2022). Furthermore, in light of current-day challenges, research has yet to address how context impacts innovation and entrepreneurial ecosystems and their actors and elements (Wurth et al., 2022). The aim of this cumulative thesis is to provide a deeper understanding of the conceptualization, operationalization, and measurement of innovation and entrepreneurial ecosystems and investigate how contextual factors can influence the overall ecosystem and its key actors. To this end, bibliometric and empirical-qualitative methods, as well as narrative and systematic literature reviews, are employed. After introducing the research scope and key concepts in Chapter 1, a systematic literature review to operationalize and measure the concept of innovation ecosystems is conducted, and an integrative framework of its composition is introduced in Chapter 2. In Chapter 3, the innovation journal network is outlined by means of science mapping to determine current and emerging research areas characterizing innovation studies. In Chapters 4 and 5, the interplay between the temporal context of the Covid-19 pandemic and the spatial context of entrepreneurial ecosystems is assessed by focusing on the role of organizational resilience and affordances. The findings shed new light on the dynamics and boundaries of entrepreneurial ecosystems as they move between the spatial and digital realm. Building on this, an integrative framework of digital entrepreneurial ecosystems is presented in Chapter 6. The concluding Chapter 7 summarizes my thesis's conceptual, theoretical, and empirical insights, highlighting implications, limitations, and promising future research avenues. The findings of this cumulative thesis contribute to the theoretical and conceptual advancement of ecosystems in innovation and entrepreneurship by providing insights into the measurement and operationalization of its elements. Furthermore, the results show that contextual factors, such as crisis events or institutional circumstances, influence innovation and entrepreneurial ecosystems and their actors, calling for a more nuanced consideration of ecosystem configurations and dynamics. By drawing from the theory of affordances, the elements that actually afford value to the actors and how they shift between the physical and digital realm are portrayed. Based on these findings, this thesis introduces novel frameworks and conceptual advancements of the configurations and boundaries of innovation and (digital) entrepreneurial ecosystems, laying the foundation for a renewed understanding of how to design, orchestrate, and evaluate ecosystems today and in the future.},
  language  = {en}
}
@phdthesis{Schaumburg2024,
  author    = {Schaumburg, Josephine},
  title     = {Men are not better negotiators after all!},
  series = {Schriftenreihe zum Verhandlungsmanagement},
  volume    = {24},
  journal   = {Schriftenreihe zum Verhandlungsmanagement},
  publisher = {Kovac},
  address   = {Hamburg},
  isbn      = {978-3-339-13798-2},
  issn      = {2365-7898},
  school      = {Universit{\"a}t Potsdam},
  pages     = {284},
  year      = {2024},
  abstract  = {This dissertation examines the lack of clarity in the scientific literature regarding gender and negotiation performance. It is often claimed that men negotiate better than women, yet it is simultaneously emphasized that results strongly depend on context. Through the use of qualitative methods such as content analysis and critical mixed-methods review, the research question: "Are women truly inferior negotiators compared to men?" is addressed. The study comprises a descriptive and an interpretive part. The descriptive section illuminates various interpretations of gender-specific negotiation theory among citing authors, with 67\% arguing for a general superiority of men. However, given the high variance in gender-specific differences, the focus should instead be on the context-dependency of negotiation performance. Generalized statements can be made within contexts, but not across them. In the interpretive section, several factors contributing to this misinterpretation are highlighted, including discrepancies in the definition of negotiation performance and distortions in research communication.. From a scientific perspective, this study underscores the need for a nuanced sociological analysis and warns against the one-sided acceptance of inaccurate scientific interpretations. From a practical standpoint, it amplifies the voices of women affected by biased research paradigms. Overall, the dissertation clarifies the theory of gender-specific negotiation performance and advocates for the elimination of biases in scientific discourse.},
  language  = {en}
}
@phdthesis{Schuster2023,
  author    = {Schuster, Josephine},
  title     = {Der strafrechtliche Schutz rechtlich bemakelter Verm{\"o}genspositionen},
  series = {Neue juristische Beitr{\"a}ge},
  volume    = {142},
  journal   = {Neue juristische Beitr{\"a}ge},
  publisher = {utzverlag},
  address   = {M{\"u}nchen},
  isbn      = {978-3-8316-7742-9},
  school      = {Universit{\"a}t Potsdam},
  pages     = {312},
  year      = {2023},
  abstract  = {Unterliegt illegales Verm{\"o}gen dem strafrechtlichen Verm{\"o}gensschutz? Die Beantwortung dieser Frage ist seit Jahren in der Strafrechtswissenschaft umstritten und f{\"u}hrt zu einer Vielzahl an Meinungen. St{\"a}rken und Schw{\"a}chen der in der Literatur vertretenen Ansichten sind bis heute Gegenstand einer andauernden wissenschaftlichen Diskussion. Dennoch fehlt es an einer umfassenden Untersuchung der h{\"o}chstrichterlichen Rechtsprechungspraxis - diese L{\"u}cke soll die vorliegende Arbeit schließen. Um die F{\"u}lle der daf{\"u}r untersuchten Entscheidungen systematisch darzustellen, wurden diese in verschiedene Fallgruppen eingeordnet. Die Bildung der Fallgruppen basiert nicht wie {\"u}blich auf einem ph{\"a}nomenologischen Ansatz, sondern auf einem konsequenten systematisch-dogmatischen Ansatz. Dies erm{\"o}glicht die Betrachtung bekannter Sachverhaltskonstellationen im neuen Licht.},
  language  = {de}
}
@phdthesis{Offizier2024,
  author    = {Offizier, Frederike},
  title     = {The biosecurity individual},
  series = {American Culture Studies},
  volume    = {43},
  journal   = {American Culture Studies},
  publisher = {Transcript},
  address   = {Bielefeld},
  isbn      = {978-3-8376-7145-2},
  issn      = {2747-4380},
  doi       = {10.14361/9783839471456},
  pages     = {294},
  year      = {2024},
  abstract  = {Discoveries in biomedicine and biotechnology, especially in diagnostics, have made prevention and (self)surveillance increasingly important in the context of health practices. Frederike Offizier offers a cultural critique of the intersection between health, security and identity, and explores how the focus on risk and security changes our understanding of health and transforms our relationship to our bodies. Analyzing a wide variety of texts, from life writing to fiction, she offers a critical intervention on how this shift in the medical gaze produces new paradigms of difference and new biomedically facilitated identities: biosecurity individuals.},
  language  = {en}
}
@phdthesis{Woebbeking2024,
  author    = {W{\"o}bbeking, Cordula},
  title     = {K{\"o}rper - Karte - Text},
  series = {Sanssouci - Forschungen zur Romanistik},
  volume    = {22},
  journal   = {Sanssouci - Forschungen zur Romanistik},
  publisher = {Frank \& Timme},
  address   = {Berlin},
  isbn      = {978-3-7329-1016-8},
  issn      = {2193-9985},
  school      = {Universit{\"a}t Potsdam},
  pages     = {280},
  year      = {2024},
  abstract  = {Rabelais' Pentalogie um die Riesen Gargantua und Pantagruel spiegelt Aspekte des sich ver{\"a}ndernden Weltbildes ihrer Entstehungszeit. Diese Studie untersucht auf der Folie der Theorie des Simulakrum Schrift, wie K{\"o}rpermodellierungen und kartographisches imaginaire durch den Autor als Strategien der Verh{\"u}llung verborgener Botschaften eingesetzt werden. Sie zeigt an ausgew{\"a}hlten Beispielen des Quart Livre die Aufweichung der Grenzen von K{\"o}rper, Karte und Text und deren Durchdringung. Die Metaphorizit{\"a}t des Textes gibt Aufschluss {\"u}ber seine Autoreflexivit{\"a}t und bewirkt eine gleichsam ganzheitliche Lekt{\"u}reerfahrung. Schließlich avanciert die Fiktion in ihrer Trugbildhaftigkeit als grotesk-sinnlicher K{\"o}rper und polysemantische Karte zum Welterkl{\"a}rungsmodell, das jedoch erst dechiffriert werden muss.},
  language  = {de}
}
@phdthesis{Bastian2023,
  author    = {Bastian, Martin},
  title     = {An emergent machine learning approach for seasonal cyclone activity forecasts},
  school      = {Universit{\"a}t Potsdam},
  pages     = {135},
  year      = {2023},
  abstract  = {Seasonal forecasts are of great interest in many areas. Knowing the amount of precipitation for the upcoming season in regions of water scarcity would facilitate a better water management. If farmers knew the weather conditions of the upcoming summer at sowing time, they could select those cereal species that are best adapted to these conditions. This would allow farmers to improve the harvest and potentially even reduce the amount of pesticides used. However, the undoubted advantages of seasonal forecasts are often opposed by their high degree of uncertainty. The great challenge of generating seasonal forecasts with lead times of several months mainly originates from the chaotic nature of the earth system. In a chaotic system, even tiny differences in the initial conditions can lead to strong deviations in the system's state in the long run. In this dissertation we propose an emergent machine learning approach for seasonal forecasting, called the AnlgModel. The AnlgModel combines the analogue method with myopic feature selection and bootstrapping. To benchmark the abilities of the AnlgModel we apply it to seasonal cyclone activity forecasts in the North Atlantic and Northwest Pacific. The AnlgModel demonstrates competitive hindcast skills with two operational forecasts and even outperforms these for long lead times. In the second chapter we comprehend the forecasting strategy of the Anlg-Model. We thereby analyse the analogue selection process for the 2017 North Atlantic and the 2018 Northwest Pacific seasonal cyclone activity. The analysis shows that those climate indices which are known to influence the seasonal cyclone activity, such as the Ni{\~n}o 3.4 SST, are correctly represented among the selected analogues. Furthermore the selected analogues reflect large-scale climate patterns that were identified by expert reports as being determinative for these particular seasons. In the third chapter we analyse the features that are used by the AnlgModel for its predictions. We therefore inspect the feature relevance (FR). The FR patterns learned by the AnlgModel show a high congruence with the predictor regions used by the operational forecasts. However, the AnlgModel also discovered new features, such as the SST anomaly in the Gulf of Guinea during November. This SST pattern exhibits a remarkably high predictive potential for the upcoming Atlantic hurricane activity. In the final chapter we investigate potential mechanisms, that link two of these regions with high feature relevance to the Atlantic hurricane activity. We mainly focus on ocean surface transport. The ocean surface flow paths are calculated using Lagrangian particle analysis. We demonstrate that the FR patterns in the region of the Canary islands do not correspond with ocean surface transport. It is instead likely that these FR patterns fingerprint a wind transport of latent heat. The second region to be studied is situated in the Gulf of Guinea. Our analysis shows that the FR patterns seen there do fingerprint ocean surface transport. However, our simulations also show that at least one other mechanism is involved in linking the Gulf of Guinea SST anomaly in November to the hurricane activity of the upcoming season. In this work the AnlgModel does not only demonstrate its outstanding forecast skills but also shows its capabilities as research tool for detecting oceanic and atmospheric mechanisms.},
  language  = {en}
}
@phdthesis{Pankaj2023,
  author    = {Pankaj, Rishabh},
  title     = {Epigenetic reprogramming of seed development},
  school      = {Universit{\"a}t Potsdam},
  pages     = {182},
  year      = {2023},
  abstract  = {The development of seeds in angiosperms starts with a complex process of double fertilization, involving the fusion of the maternal egg cell and central cell with two paternal sperm cells. This gives rise to the embryo and the nourishing endosperm, which are then enclosed by the seed coat, derived from the maternal integuments. The growth of the seed coat in Arabidopsis thaliana (Arabidopsis) is actively inhibited before fertilization by epigenetic regulators known as Polycomb Group (PcG) proteins. These proteins deposit a repressive histone mark called H3K27me3, which must be removed to enable seed coat formation. In this thesis, I explored the mechanism of removal of H3K27me3 marks from the integument cells following fertilization, which allows for seed coat formation. We hypothesized that this removal should be primarily facilitated by histone demethylases from the JMJ family and potentially influenced by the plant hormones Brassinosteroids (BRs). This hypothesis was supported by the expression patterns of the JMJ protein REF6 and of BR related genes, which are specifically expressed in the integuments and in the seed coat. Moreover, mutations in both these pathways lead to developmental defects, such as reduced ovule viability and delayed seed coat growth. Our research provides evidence suggesting that BR signalling is likely involved in recruiting JMJ-type histone demethylases to target loci responsible for seed coat growth. Moreover, we have discovered an additional pathway through which BRs regulate seed coat development, independent of their influence on H3K27me3 marks. This finding emphasizes the diverse roles of BRs in coordinating seed development, extending beyond their well-known involvement in plant growth and development. Furthermore, I explored the role of another epigenetic mark, DNA methylation, in fertilization-independent (or autonomous) seed formation in Arabidopsis. For this, we utilized epigenetic Recombinant Inbred Lines (epiRILs) and thus identified an epigenetic Quantitative Trait Locus (epiQTL) on chromosome II, potentially responsible for the larger autonomous seed size observed in DNA methylation mutants. Overall, this thesis significantly enhances our comprehension of the intricate relationship between epigenetic modifications, hormonal signaling, and plant reproductive processes. It offers valuable insights into the genetic mechanisms governing both sexual and asexual seed formation, while also presenting potential avenues for the engineer of advantageous traits in agricultural crops.},
  language  = {en}
}
@phdthesis{BastosLima2023,
  author    = {Bastos Lima, Rita},
  title     = {Seed coat-derived brassnosteroids non-cell autonomously regulate endosperm development},
  school      = {Universit{\"a}t Potsdam},
  pages     = {157},
  year      = {2023},
  language  = {en}
}
@phdthesis{Kulshreshtha2023,
  author    = {Kulshreshtha, Ritika},
  title     = {Dissecting the functional of role of microtubule and cellulose microfibril patterning during flower development in Arabidopsis},
  school      = {Universit{\"a}t Potsdam},
  pages     = {215},
  year      = {2023},
  language  = {en}
}
@phdthesis{Ellenbeck2023,
  author    = {Ellenbeck, Saskia},
  title     = {Zwischen Modellierung und Stakeholderbeteiligung - Wissensproduktion in der Energiewendeforschung},
  school      = {Universit{\"a}t Potsdam},
  pages     = {130},
  year      = {2023},
  abstract  = {Die Dekarbonisierung des Energiesystems ist Teil der international im Rahmen des Pariser Klimaabkommens beschlossenen CO2-Minderungsstrategie zur Bek{\"a}mpfung des Klimawandels. Nach den Verhandlungen und Beschl{\"u}ssen der Klimaziele stehen politische Entscheider weltweit nun vor der Frage, wie sie diese erreichen k{\"o}nnen. Dies produziert eine hohe politische Nachfrage nach Wissen um die direkten und indirekten Effekte verschiedener Instrumente und potentiellen Entwicklungspfade einer Energiewende. Dieser gesellschaftliche Bedarf an wissenschaftlichen Antworten zu L{\"o}sungsoptionen wurde im Rahmen einer Klimafolgenforschung, genauer einer Klimapolitikfolgenforschung, aufgenommen. Der relativ neue Zweig einer Energiewendeforschung hat sich weltweit entwickelt, steht dabei allerdings vor der doppelten Herausforderung: Erstens befindet sich das Objekt der Forschung nicht im luftleeren Raum, sondern innerhalb {\"o}konomischer, sozialer und politischer Zusammenh{\"a}nge, hier gesellschaftliche Einbettung genannt. Denn die Frage, wie die Energiewende erreicht werden kann, wird auch außerhalb der Wissenschaft debattiert und stellt damit ein Aushandlungsfeld unterschiedlicher Interessen und Narrative dar. Zweitens befindet sich das zu untersuchende Objekt in der Zukunft, hier unter dem Terminus des strukturellen Nicht-Wissens zusammengefasst. Diese beiden Bedingungen f{\"u}hren dazu, dass konventionelle Methoden der empirischen Sozialforschung nicht greifen und eine {\"O}ffnung und Transformation der Wissenschaft in Hinblick auf neue Methoden vonn{\"o}ten ist (Nowotny 2001, Ravetz 2006, Schneidewind 2013). In dieser Arbeit untersuche ich zwei M{\"o}glichkeiten, wie mit der Herausforderung, Wissen unter der Bedingung des strukturellen Nicht-Wissens und der gesellschaftlichen Einbettung zu produzieren, in der Energiewendeforschung umgegangen wird. Einerseits wird dies durch die Einbeziehung von Stakeholdern, also nicht-wissenschaftlicher Akteure, in den Forschungsprozess getan. Andererseits ist die Nutzung von komplexen {\"o}konometrischen Modellen zur Berechnung von Implikationen und energiewirtschaftlichen Entwicklungspfaden zu einem zentralen Mittel der Wissensgenerierung in der Energiewendeforschung avanciert. Damit wird der als Problem verstandenen strukturellen Bedingung des Nicht-Wissens insofern begegnet, als dass die Ergebnisse von Stakeholder-Involvement und von Modellierungsarbeiten zweifelsohne neues Wissen zur Verf{\"u}gung stellen. Uneinigkeit besteht jedoch darin, wor{\"u}ber dieses Wissen etwas aussagt: Sind es Interessen oder legitime Perspektiven, die Stakeholder in den Forschungsprozess einbringen und sind Modelle vereinfachte Darstellungen der Welt oder sind sie Ausdruck der Vorstellung des Modellierers?},
  language  = {de}
}
@phdthesis{Dommes2023,
  author    = {Dommes, Bianca},
  title     = {»… und am Himmel standen die Sterne, aber wir sahen sie nicht«},
  series = {Potsdamer J{\"u}dische Studien},
  volume    = {10},
  journal   = {Potsdamer J{\"u}dische Studien},
  publisher = {be.bra wissenschaft},
  address   = {Berlin},
  isbn      = {978-3-95410-316-4},
  school      = {Universit{\"a}t Potsdam},
  pages     = {448},
  year      = {2023},
  language  = {de}
}
@phdthesis{SantosBruss2020,
  author    = {Santos Bruss, Sara Morais dos},
  title     = {Feminist solidarities after modulation},
  publisher = {punctum books},
  address   = {Brooklyn, NY},
  isbn      = {978-1-68571-146-7},
  doi       = {10.53288/0397.1.00},
  school      = {Universit{\"a}t Potsdam},
  pages     = {xiii, 380},
  year      = {2020},
  abstract  = {Feminist Solidarities after Modulation produces an intersectional analysis of transnational feminist movements and their contemporary digital frameworks of identity and solidarity. Engaging media theory, critical race theory, and Black feminist theory, as well as contemporary feminist movements, this book argues that digital feminist interventions map themselves onto and make use of the multiplicity and ambiguity of digital spaces to question presentist and fixed notions of the internet as a white space and technologies in general as objective or universal. Understanding these frameworks as colonial constructions of the human, identity is traced to a socio-material condition that emerges with the modernity/colonialism binary. In the colonial moment, race and gender become the reasons for, as well as the effects of, technologies of identification, and thus need to be understood as and through technologies. What Deleuze has called modulation is not a present modality of control, but is placed into a longer genealogy of imperial division, which stands in opposition to feminist, queer, and anti-racist activism that insists on non-modular solidarities across seeming difference. At its heart, Feminist Solidarities after Modulation provides an analysis of contemporary digital feminist solidarities, which not only work at revealing the material histories and affective ""leakages"" of modular governance, but also challenges them to concentrate on forms of political togetherness that exceed a reductive or essentialist understanding of identity, solidarity, and difference.},
  language  = {en}
}
@phdthesis{Hu2022,
  author    = {Hu, Changqiong},
  title     = {Characterization of the role of stress - responsive NAC transcription factors ANAC055 and ATAF1},
  school      = {Universit{\"a}t Potsdam},
  pages     = {XI, 106},
  year      = {2022},
  language  = {en}
}
@phdthesis{Eiken2023,
  author    = {Eiken, Jan},
  title     = {Das Staatenbeschwerdeverfahren der Rassendiskriminierungskonvention},
  series = {Packages Social Science and Law (German Language)},
  volume    = {1},
  journal   = {Packages Social Science and Law (German Language)},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-662-68217-3},
  doi       = {10.1007/978-3-662-68218-0},
  school      = {Universit{\"a}t Potsdam},
  pages     = {XIV, 359},
  year      = {2023},
  abstract  = {Obwohl sieben der neun Menschenrechtsvertr{\"a}ge auf Ebene der Vereinten Nationen die M{\"o}glichkeit eines Staatenbeschwerdeverfahrens er{\"o}ffnen, kam dieser Verfahrensart {\"u}ber Jahrzehnte hinweg keinerlei praktische Bedeutung zu. Im Fr{\"u}hjahr 2018 erreichten den CERD-Ausschuss dann jedoch gleich drei verschiedene Staatenmitteilungen. Die erstmalige Aktivierung des Verfahrens fast 50 Jahre nach Inkrafttreten des Internationalen {\"U}bereinkommens zur Beseitigung jeder Form von Rassendiskriminierung (CERD) kann dabei als eine historische Entwicklung bezeichnet werden. Vor diesem Hintergrund bietet dieses Buch erstmals eine umfassende Auseinandersetzung mit dem Staatenbeschwerdeverfahren nach Art. 11-13 CERD und den sich daraus ergebenden v{\"o}lkerrechtlichen Fragen. Unter Auswertung der j{\"u}ngsten Praxis des CERD-Ausschusses und der ad hoc Vergleichskommission wird die Funktionsweise des Verfahrens detailliert dargestellt, wobei immer wieder Parallelen zu den Mechanismen anderer Vertragsregime gezogen werden. Auf diese Weise soll die Arbeit auch zu dem Verst{\"a}ndnis vergleichbarer Staatenbeschwerdeverfahren anderer Menschenrechtsvertr{\"a}ge beitragen und zugleich die Bedeutung des Ph{\"a}nomens zwischenstaatlicher Streitbeilegung in Menschenrechtsfragen st{\"a}rker in den Vordergrund r{\"u}cken.},
  language  = {de}
}
@phdthesis{Machani2023,
  author    = {Machani, Fridah Gechemba},
  title     = {Functional analysis of ATAF1 and ANAC032 NAC transcription factors in response to nitrogen Supply in Arabidopsis thaliana},
  school      = {Universit{\"a}t Potsdam},
  pages     = {126},
  year      = {2023},
  language  = {en}
}
@phdthesis{RomeroPrada2023,
  author    = {Romero Prada, Lorena Margarita},
  title     = {Crop improvement towards oxidative stress},
  school      = {Universit{\"a}t Potsdam},
  pages     = {155},
  year      = {2023},
  language  = {en}
}
@phdthesis{Sharma2023,
  author    = {Sharma, Anjali},
  title     = {Optical manipulation of multi-responsive microgels},
  school      = {Universit{\"a}t Potsdam},
  pages     = {207},
  year      = {2023},
  abstract  = {This dissertation focuses on the understanding of the optical manipulation of microgels dispersed in aqueous solution of azobenzene containing surfactant. The work consists of three parts where each part is a systematic investigation of the (1) photo-isomerization kinetics of the surfactant in complex with the microgel polymer matrix, (2) light driven diffusiosmosis (LDDO) in microgels and (3) photo-responsivity of microgel on complexation with spiropyran. The first part comprises three publications where the first one [P1] investigates the photo-isomerization kinetics and corresponding isomer composition at a photo-stationary state of the photo-sensitive surfactant conjugated with charged polymers or micro sized polymer networks to understand the structural response of such photo-sensitive complexes. We report that the photo-isomerization of the azobenzene-containing cationic surfactant is slower in a polymer complex compared to being purely dissolved in an aqueous solution. The surfactant aggregates near the polyelectrolyte chains at concentrations much lower than the bulk critical micelle concentration. This, along with the inhibition of the photo-isomerization kinetics due to steric hindrance within the densely packed aggregates, pushes the isomer-ratio to a higher trans-isomer concentration for all irradiation wavelengths. The second publication [P2] combines experimental results and non-adiabatic dynamic simulations for the same surfactant molecules embedded in the micelles with absorption spectroscopy measurements of micellar solutions to uncover the reasons responsible for the slowdown in photo induced trans → cis azobenzene isomerization at concentrations higher than the critical micelle concentration (CMC). The simulations reveal a decrease of isomerization quantum yields for molecules inside the micelles and observes a reduction of extinction coefficients upon micellization. These findings explain the deceleration of the trans → cis switching in micelles of the azobenzene-containing surfactants. Finally, the third publication [P3] focusses on the kinetics of adsorption and desorption of the same surfactant within anionic microgels in the dark and under continuous irradiation. Experimental data demonstrate, that microgels can serve as a selective absorber of the trans isomers. The interaction of the isomers with the gel matrix induces a remotely controllable collapse or swelling on appropriate irradiation wavelengths. Measuring the kinetics of the microgel size response and knowing the exact isomer composition under light exposure, we calculate the adsorption rate of the trans-isomers. The second part comprises two publications. The first publication [P4] reports on the phenomenon of light-driven diffusioosmotic (DO) long-range attractive and repulsive interactions between micro-sized objects, whose range extends several times the size of microparticles and can be adjusted to point towards or away from the particle by varying irradiation parameters such as intensity or wavelength of light. The phenomenon is fueled by the aforementioned photosensitive surfactant. The complex interaction of dynamic exchange of isomers and photo-isomerization rate yields to relative concentrations gradients of the isomers in the vicinity of micro-sized object inducing a local diffusioosmotic (DO) flow thereby making a surface act as a micropump. The second publication [P5] exclusively aims the visualization and investigation of the DO flows generated from microgels by using small tracer particles. Similar to micro sized objects, the flow is able to push adjacent tracers over distances several times larger than microgel size. Here we report that the direction and the strength of the l-LDDO depends on the intensity, irradiation wavelength and the amount of surfactant adsorbed by the microgel. For example, the flow pattern around a microgel is directed radially outward and can be maintained quasi-indefinitely under exposure at 455 nm when the trans:cis ratio is 2:1, whereas irradiation at 365 nm, generates a radially transient flow pattern, which inverts at lower intensities. Lastly, the third part consists of one publication [P6] which, unlike the previous works, reports on the study of the kinetics of photo- and thermo-switching of a new surfactant namely, spiropyran, upon exposure with light of different wavelengths and its interaction with p(NIPAM-AA) microgels. The surfactant being an amphiphile, switches between its ring closed spiropyran (SP) form and ring open merocyanine (MC) form which results in a change in the hydrophilic-hydrophobic balance of the surfactant as MC being a zwitterionic form along with the charged head group, generates three charges on the molecule. Therefore, the MC form of the surfactant is more hydrophilic than in the case of the neutral SP state. Here, we investigate the initial shrinkage of the gel particles via charge compensation on first exposure to SP molecules which results from the complex formation of the molecules with the gel matrix, triggering them to become photo responsive. The size and VPTT of the microgels during irradiation is shown to be a combination of heating up of the solution during light absorption by the surfactant (more pronounced in the case of UV irradiation) and the change in the hydrophobicity of the surfactant.},
  language  = {en}
}
@phdthesis{Agarwal2023,
  author    = {Agarwal, Pallavi},
  title     = {Functional characterization of ROS-responsive genes, ANAC085 and ATR7, in Arabidopsis thaliana},
  school      = {Universit{\"a}t Potsdam},
  pages     = {XVII, 169},
  year      = {2023},
  language  = {en}
}
@phdthesis{Peng2023,
  author    = {Peng, Maolin},
  title     = {The role of prion-like domains in plant temperatur sensing},
  school      = {Universit{\"a}t Potsdam},
  pages     = {XVI, 121},
  year      = {2023},
  language  = {en}
}
@phdthesis{Stephan2023,
  author    = {Stephan, Mareike Sophia},
  title     = {A bacterial mimetic system to study bacterial inactivation and infection},
  school      = {Universit{\"a}t Potsdam},
  pages     = {150},
  year      = {2023},
  abstract  = {The emerging threat of antibiotic-resistant bacteria has become a global challenge in the last decades, leading to a rising demand for alternative treatments for bacterial infections. One approach is to target the bacterial cell envelope, making understanding its biophysical properties crucial. Specifically, bacteriophages use the bacterial envelope as an entry point to initiate infection, and they are considered important building blocks of new antibiotic strategies against drug-resistant bacteria.. Depending on the structure of the cell wall, bacteria are classified as Gram-negative and Gram-positive. Gram-negative bacteria are equipped with a complex cell envelope composed of two lipid membranes enclosing a rigid peptidoglycan layer. The synthesis machinery of the Gram-negative cell envelope is the target of antimicrobial agents, including new physical sanitizing procedures addressing the outer membrane (OM). It is therefore very important to study the biophysical properties of the Gram-negative bacterial cell envelope. The high complexity of the Gram-negative OM sets the demand for a model system in which the contribution of individual components can be evaluated separately. In this respect, giant unilamellar vesicles (GUVs) are promising membrane systems to study membrane properties while controlling parameters such as membrane composition and surrounding medium conditions. The aim of this work was to develop methods and approaches for the preparation and characterization of a GUV-based membrane model that mimics the OM of the Gram-negative cell envelope. A major component of the OM is the lipopolysaccharide (LPS) on the outside of the OM heterobilayer. The vesicle model was designed to contain LPS in the outer leaflet and lipids in the inner leaflet. Furthermore, the interaction of the prepared LPS-GUVs with bacteriophages was tested. LPS containing GUVs were prepared by adapting the inverted emulsion technique to meet the challenging properties of LPS, namely their high self-aggregation rate in aqueous solutions. Notably, an additional emulsification step together with the adaption of solution conditions was employed to asymmetrically incorporate LPS containing long polysaccharide chains into the artificial membranes. GUV membrane asymmetry was verified with a fluorescence quenching assay. Since the necessary precautions for handling the quenching agent sodium dithionite are often underestimated and poorly described, important parameters were tested and identified to obtain a stable and reproducible assay. In the context of varied LPS incorporation, a microscopy-based technique was introduced to determine the LPS content on individual GUVs and to directly compare vesicle properties and LPS coverage. Diffusion coefficient measurements in the obtained GUVs showed that increasing LPS concentrations in the membranes resulted in decreased diffusivity. Employing LPS-GUVs we could demonstrate that a Salmonella bacteriophage bound with high specificity to its LPS receptor when presented at the GUV surface, and that the number of bound bacteriophages scaled with the amount of presented LPS receptor. In addition to binding, the bacteriophages were able to eject their DNA into the vesicle lumen. LPS-GUVs thus provide a starting platform for bottom-up approaches for the generation of more complex membranes, in which the effects of individual components on the membrane properties and the interaction with antimicrobial agents such as bacteriophages could be explored.},
  language  = {en}
}
@phdthesis{Li2023,
  author    = {Li, Xiaoping},
  title     = {Regulation of starch granule number and morphology in arabidopsis thaliana},
  school      = {Universit{\"a}t Potsdam},
  pages     = {116},
  year      = {2023},
  language  = {en}
}
@phdthesis{Koelman2023,
  author    = {Koelman, Liselot A.},
  title     = {The role of diet in immune health and ageing},
  school      = {Universit{\"a}t Potsdam},
  year      = {2023},
  language  = {en}
}
@phdthesis{RuoffnerUnterrainer2023,
  author    = {Ruoffner-Unterrainer, Simone},
  title     = {Zwischen Verein, Korporation und Gesinnungsgemeinschaft},
  series = {Abhandlungen zum Studenten- und Hochschulwesen},
  volume    = {22},
  journal   = {Abhandlungen zum Studenten- und Hochschulwesen},
  publisher = {B{\"o}hlau},
  address   = {Wien ; K{\"o}ln},
  isbn      = {978-3-412-52837-9},
  school      = {Universit{\"a}t Potsdam},
  pages     = {455},
  year      = {2023},
  language  = {de}
}
@phdthesis{Klein2023,
  author    = {Klein, Jonas},
  title     = {Der Prophet des Staatsgedankens},
  series = {Schriftenreihe der Historischen Kommission bei der Bayerischen Akademie der Wissenschaften},
  volume    = {111},
  journal   = {Schriftenreihe der Historischen Kommission bei der Bayerischen Akademie der Wissenschaften},
  publisher = {Vandenhoeck \& Ruprecht},
  address   = {G{\"o}ttingen},
  isbn      = {978-3-525-30238-5},
  issn      = {0568-4323},
  pages     = {471},
  year      = {2023},
  abstract  = {Kaum eine Studie zum Deutschen Kaiserreich kommt ohne einen Verweis auf die »Preußischen Jahrb{\"u}cher« als einflussreicher Stimme der Zeit aus, deren Herausgeber Hans Delbr{\"u}ck keine Kontroverse scheute. Jonas Kleins systematische Beziehungsgeschichte untersucht, woher das Vertrauen resultierte, das Hans Delbr{\"u}ck als politischer Intellektueller partei{\"u}bergreifend genoss. Indem die wichtigsten innen- und außenpolitischen Krisenherde des Kaiserreichs in den Blick genommen werden, kristallisieren sich die politischen Grundlinien heraus, auf die Delbr{\"u}ck die »Preußischen Jahrb{\"u}cher« verpflichtete: f{\"u}r einen starken Staat, kulturellen Liberalismus, progressive Sozialpolitik und nationale Integration. Sein unerm{\"u}dlicher, keineswegs solit{\"a}rer Kampf f{\"u}r einen »aufgekl{\"a}rten Konservatismus« zeugt von alternativen Entwicklungsoptionen des Hohenzollernstaates.},
  language  = {de}
}
@phdthesis{Batti2023,
  author    = {Batti, Anil Dominic},
  title     = {Schopenhauer's doctrine of salvation in relation to his critique of religion and philosophical teachings},
  publisher = {Logos},
  address   = {Berlin},
  isbn      = {978-3-83255-735-5},
  school      = {Universit{\"a}t Potsdam},
  pages     = {319},
  year      = {2023},
  abstract  = {Arthur Schopenhauer (1788-1860) was perhaps the last polymath among the great Germanic philosophers. Switching with ease and elegance between epistemic positions and fields as diverse as idealism and empiricism, fideism and rationalism, realism and nominalism, art and religion, jurisprudence and politics, psychology and occultism, Schopenhauer erected an imposing edifice bearing testimony to his universal learning. This study is an investigation into the very conclusion of Schopenhauer's philosophy and endeavours to answer the following question: did Schopenhauer's doctrine of salvation issue forth organically from his intellectual output or was it annexed to his philosophy as a result of his critical engagement with religion? The labyrinthine paths through which Schopenhauer arrives at the soteriological culmination of his philosophy are subjected to critical assessment; the picture that emerges is of a philosopher who seemed convinced that he had solved some of the most pressing cosmic riddles to have tormented mankind through the ages.},
  language  = {en}
}
@phdthesis{Khawaja2023,
  author    = {Khawaja, Muhammad Asim},
  title     = {Improving earthquake forecast modeling and testing using the multi-resolution grids},
  school      = {Universit{\"a}t Potsdam},
  pages     = {107},
  year      = {2023},
  language  = {en}
}
@phdthesis{Sajedi2023,
  author    = {Sajedi, Maryam},
  title     = {Investigation of metal-halide-perovskites by state-of-the-art synchrotron-radiation methods},
  school      = {Universit{\"a}t Potsdam},
  pages     = {xviii, 149},
  year      = {2023},
  abstract  = {My thesis chiefly aims to shed light on the favourable properties of LHP semiconductors from the point of view of their electronic structure. Currently, various hypotheses are circulating to explain the exceptionally favourable transport properties of LHPs. Seeking an explanation for the low non-radiative recombination rates and long carrier lifetimes is particularly interesting to the halide perovskites research community. The first part of this work investigates the two main hypotheses that are believed to play a significant role: the existence of a giant Rashba effect and large polarons. The experimental method of ARPES is mainly applied to verify their credibility. The first hypothesis presumes that a giant Rashba effect restricts the recombination losses of the charge carriers by making the band gap slightly indirect. The Rashba effect is based on a strong SOC that could appear in LHPs thanks to incorporating the heavy element Pb in their structure. Earlier experimental work had pointed out this effect at the VBM of a hybrid LHP as a viable explanation for the long lifetimes of the charge carriers. My systematic ARPES studies on hybrid MAPbBr3 and spin-resolved ARPES studies on the inorganic CsPbBr3 disprove the presence of any Rashba effect in the VBM of the reported order of magnitude. Therefore, neither the spin texture nor an indirect band gap character at the VBM in the bulk or at the surface can explain the high efficiency of LHP. In case of existence, this effect is in terms of the Rashba parameter at least a factor of a hundred smaller than previously assumed. The second hypothesis proposes large polaron formation in the electronic structure of LHPs and attributes it to their high defect tolerance and low non-radiative recombination rate. Because the perovskite structure consists of negative and positive ions, polarons of this kind can be expected due to the Coulomb interaction between carriers and the polar lattice at intermediate electron-phonon coupling strength. Their existence is proposed to screen the carriers and defects to avoid recombination and trapping, thus leading to long carrier lifetimes. ARPES results by one group supported this assumption, reporting a 50\% effective mass enhancement over the theoretical effective mass for CsPbBr3 in the orthorhombic structure. The current thesis examines this hypothesis experimentally by photon-energy-dependent ARPES spectra and theoretically by GW band calculations of CsPbBr3 perovskites. The investigation is based on the fact that a polaron contribution in charge transport can become evident by an increase of the effective mass as measured by ARPES over the calculated one without polaron effects. However, my experiments on crystalline CsPbBr3 did not imply a larger effective mass for which one could postulate large polarons. In fact, the effective masses determined from ARPES agree with that of theoretical predictions. The second part of my thesis thoroughly investigates the possibility of spontaneously magnetizing LHPs by introducing Mn2+ ions. Mn doping was reported to cause ferromagnetism in one of the most common LHPs, MAPbI3, mediated by super-exchange. The current work investigates the magnetic properties of a wide concentration range of Mn-doped MAPbI3 and triple-cation films by XAS, XMCD, and SQUID measurements. Based on the XAS line shape and a sum-rule analysis of the XMCD spectra, a pure Mn2+ configuration has been confirmed. Negative Curie temperatures are extracted from fitting the magnetization with a Curie-Weiss law. However, a remanent magnetization, which would be an indication of the absence of ferromagnetism down to 2K. As far as the double exchange is concerned, the element-specific XAS excludes a sufficient amount of Mn3+ as a prerequisite for this mechanism. All the findings show no evidence of significant double exchange or ferromagnetism in Mn-doped LHPs. The magnetic behavior is paramagnetic rather than ferromagnetic. In the dissertation's last chapter, orthorhombic features of CsPbBr3 are revealed by ARPES, including an extra VBM at the Γ-point. The VBM of CsPbBr3 shows a temperature-dependent splitting, which decreases by 190 meV between 38K and 300K and tracks a shift of a saddle point at the cubic M-point. It is possible to reproduce the energy shift using an atomic model with a larger unit cell for room temperature, allowing local inversion symmetry breaking. This indicates the importance of electric dipoles for the inorganic LHPs, which may contribute to their high efficiency by breaking inversion symmetry and a Berry-phase effect.},
  language  = {en}
}
@phdthesis{Pietrek2023,
  author    = {Pietrek, Anou F.},
  title     = {Basic psychological needs and depression in the context of health and exercise},
  school      = {Universit{\"a}t Potsdam},
  year      = {2023},
  abstract  = {Depressive Erkrankungen gehen mit verminderter Lebenszufriedenheit und reduzierter Arbeitsf{\"a}higkeit einher. Die Wartezeit f{\"u}r eine Psychotherapie betr{\"a}gt in Deutschland derzeit zwischen drei und sechs Monaten. Demnach besteht Bedarf an alternativen, gleichwertigen evidenzbasierten Behandlungsm{\"o}glichkeiten, die den Betroffenen niedrigschwellig zug{\"a}nglich gemacht werden. Eine Vielzahl an empirischen Studien belegt die Wirksamkeit von Sport bei leichten und mittelschweren Depressionen. Zur weiterf{\"u}hrenden Konzeption und Qualit{\"a}tssicherung von Sport als Behandlungsoption ist es notwendig die konkreten Wirkmechanismen zu verstehen. Neben physiologischen spielen auch psychologische Faktoren eine Rolle im Wirkungsgeschehen. Als Metatheorie menschlichen Erlebens und Verhaltens bietet die Selbstbestimmungstheorie (engl.: Self-Determination Theory; SDT) einen n{\"u}tzlichen Bezugsrahmen zum Verst{\"a}ndnis psychologischer Wirkmechanismen mit konkreten Ableitungen f{\"u}r die Behandlungspraktik. Die konzeptionelle Erweiterung der SDT um die Frustration psychologischer Grundbed{\"u}rfnisse erweist sich neben der Bed{\"u}rfnisbefriedigung zunehmend als hilfreich bei der Untersuchung von psychischen Erkrankungen. Der erste Teil dieser Dissertation besteht aus zwei Publikationen, die relevante Messinstrumente in dem genannten Kontext validieren. Der erste Fragebogen misst das Ausmaß an allgemein erlebter Befriedigung und Frustration der psychologischen Grundbed{\"u}rfnisse nach Autonomie, Kompetenz und sozialer Eingebundenheit. Der zweite Fragebogen erhebt die erlebte Bed{\"u}rfnisbefriedigung durch die anleitende Person (hier: Sporttherapeut*in). Der zweite Teil der Dissertation umfasst zwei Publikationen, welche die Befriedigung und Frustration der psychologischen Grundbed{\"u}rfnisse bei depressiven Symptomen untersuchen und einordnen. Es werden die Unterschiede im Ausmaß an Bed{\"u}rfnisbefriedigung und Bed{\"u}rfnisfrustration zwischen einer Stichprobe mit Depression mit einer Stichprobe ohne depressive Symptome untersucht. Der Zusammenhang zwischen Bed{\"u}rfnisfrustration und depressiven Symptomen wird im Kontext etablierter pathologischer Prozesse (Emotionsdysregulation, Rumination) eingeordnet. Die Hauptergebnisse dieser Arbeiten zeigen, dass die SDT durch die Erweiterung der Basic Psychological Needs Theory um die Dimension der Bed{\"u}rfnisfrustration ein nun breiteres Spektrum auf dem Gesundheit-Krankheit-Kontinuum abbildet. Dabei fokussiert die SDT auf die psychologische Wirkung von sozialen Umwelten. Neben der Nichterf{\"u}llung der psychologischen Grundbed{\"u}rfnisse ist es vor allem die Bed{\"u}rfnisfrustration, die einen allgemeinen Vulnerabilit{\"a}tsfaktor f{\"u}r das Vorkommen psychologischer Erkrankungen darstellt. Zudem weist die unausgewogene Befriedigung der psychologischen Grundbed{\"u}rfnisse m{\"o}glicherweise auf ein konflikthaftes Erleben zwischen den Bed{\"u}rfnissen hin. F{\"u}r die Behandlungspraktik abzuleiten ist, dass eine autonomieunterst{\"u}tzende Atmosph{\"a}re, die die ausgewogene Befriedigung aller drei Bed{\"u}rfnisse erm{\"o}glicht, zentral f{\"u}r den Behandlungserfolg ist.},
  language  = {en}
}
@phdthesis{Baryzewska2023,
  author    = {Baryzewska, Agata W.},
  title     = {Reconfigurable Janus emulsions as signal transducers for biosensing applications},
  school      = {Universit{\"a}t Potsdam},
  pages     = {133},
  year      = {2023},
  language  = {en}
}
@phdthesis{Vassilevski2023,
  author    = {Vassilevski, Ekaterina},
  title     = {Hegels Phantasie},
  series = {Edition Medienwissenschaft},
  volume    = {107},
  journal   = {Edition Medienwissenschaft},
  publisher = {Transcript},
  address   = {Bielefeld},
  isbn      = {978-3-8394-6959-0},
  school      = {Universit{\"a}t Potsdam},
  pages     = {175},
  year      = {2023},
  abstract  = {Als »Zwischenreich«, »Drittes« oder »Mitte« bezeichnet, kommt der Imagination seit ihren Anf{\"a}ngen in der Antike die Rolle eines Mediums zu. Gleichzeitig bleibt ihr medialer Aspekt durchgehend ambivalent und prek{\"a}r. Es ist Georg Wilhelm Friedrich Hegel, der die Imagination nicht mehr als subjektives Verm{\"o}gen versteht, sondern als Kraft der »Ent{\"a}ußerung« und sie somit medial denkt. In einer bislang wenig beachteten Passage aus Hegels dritter Enzyklop{\"a}die von 1830 legt Ekaterina Vassilevski nicht nur die implizite Medialit{\"a}t der Imagination frei, sondern auch den in Hegels Denken verborgenen Begriff des Medialen.},
  language  = {de}
}
@phdthesis{Lian2023,
  author    = {Lian, Tingting},
  title     = {Efficient activation of peroxymonosulfate by carbon-based catalysts for water purification},
  school      = {Universit{\"a}t Potsdam},
  pages     = {167},
  year      = {2023},
  abstract  = {The increasing global population has led to a growing demand for cost-effective and eco-friendly methods of water purification. This demand has reached a peak due to the increasing presence of impurities and pollutants in water and a growing awareness of waterborne diseases. Advanced oxidation processes (AOPs) are effective methods to address these challenges, due to the generation of highly reactive radicals, such as sulfate radical (SO4•-), hydroxyl radical (•OH), and/or superoxide radical (•O2-) in oxidation reactions. Relative to conventional hydrogen peroxide (H2O2)-based AOPs for wastewater treatment, the persulfate-related AOPs are receiving increasing attention over the past decades, due to their stronger oxidizing capability and a wider pH working window. Further deployment of the seemingly plausible technology as an alternative for the well-established one in industry, however, necessitates a careful evaluation of compounding factors, such as water matrix effects, toxicological consequences, costs, and engineering challenges, etc. To this end, rational design of efficient and environmentally friendly catalysts constitutes an indispensable pathway to advance persulfate activation efficacy and to elucidate the mechanisms in AOPs, the combined endeavors are expected to provide insightful understanding and guidelines for future studies in wastewater treatment. A dozens of transition metal-based catalysts have been developed for persulfate-related AOPs, while the undesirable metal leaching and poor stability in acidic conditions have been identified as major obstacles. Comparatively, the carbonaceous materials are emerging as alternative candidates, which are characterized by metal-free nature, wide availability, and exceptional resistance to acid and alkali, as well as tunable physicochemical and electronic properties, the combined merits make them an attractive option to overcome the aforementioned limitations in metal-based catalytic systems. This dissertation aims at developing novel carbonaceous materials to boost the activity in peroxymonosulfate (PMS) activation processes. Functionalized carbon materials with metal particles or heteroatoms were constructed and further evaluated in terms of their ability to activate PMS for AOPs. The main contents of this thesis are summarized as follows: (1) Iron oxide-loaded biochar: improving stability and alleviating metal leakage Metal leaching constitutes one of the main drawbacks in using transition metals as PMS activators, which is accompanied by the generation of metal-containing sludge, potentially leading to secondary pollution. Meanwhile, the metal nanoparticles are prone to aggregate, causing rapid decay of catalytic performance. The use of carbons as supports for transition metals could mitigate these deficiencies, because the interaction between metals and carbons could in turn disperse and stabilize metal nanoparticles, thus suppressing the metal leaching. In this work, the environmentally benign lignin with its abundant phenolic groups, which is well known to serve as carbon source with high yields and flexibility, was utilized to load Fe ions. The facile low-temperature pre-treatment pyrolytic strategy was employed to construct a green catalyst with iron oxides embedded in Kraft-lignin-derived biochar (termed as γ-Fe2O3@KC). The γ-Fe2O3@KC was capable of activating PMS to generate stable non-radical species (1O2 and Fe (V)=O) and to enhance electron transfer efficiency. A surface-bound reactive complex (catalyst-PMS*) was identified by electrochemical characterizations and discussed with primary surface-bound radical pairs to explain the contradictions between quenching and EPR detection results. The system also showed encouraging reusability for at least 5 times and high stability at pH 3-9. The low concentration of iron in γ-Fe2O3@KC/PMS system implied that the carbon scaffold of biochar substantially alleviated metal leakage. (2) MOF-derived nanocarbon: new carbon crystals Traditional carbon materials are of rather moderate performance in activation PMS, due to the poor electron transfer capacity within the amorphous structure and limited active sites for PMS adsorption. Herein, we established crystalline nanocarbon materials via a simple NaCl-templated strategy using the monoclinic zeolitic imidazolate framework-8 (ZIF-8) sealed with NaCl crystals as the precursors. Specifically, NaCl captured dual advantages in serving as structure-directing agent during hydrolysis and protective salt reactor to facilitate phase transformation during carbonization. The structure-directing agent NaCl provided a protective and confined space for the evolution of MOF upon carbonization, which led to high doping amounts of nitrogen (N) and oxygen elements (O) in carbon framework (N: 14.16 wt\%, O: 9.6 wt\%) after calcination at a high temperature of 950 oC. We found that N-O co-doping can activate the chemically inert carbon network and the nearby sp2-hybridized carbon atoms served as active sites for adsorption and activation. Besides, the highly crystallized structure with well-established carbon channels around activated carbon atoms could significantly accelerate electron transfer process after initial adsorption of PMS. As such, this crystalline nanocarbon exhibited excellent catalytic kinetics for various pollutants. (3) MOF-derived 2D carbon layers: enhanced mass/electron transfer The two-dimensional (2D) configuration of carbon-based nanosheets with inherent nanochannels and abundant active sites residing on the layer edges or in between the layers, allowed the accessible interaction and close contact between the substrates and reactants, as well as the dramatically improved electron- and mass-transfer kinetics. In this regard, we developed dual-templating strategy to afford 2D assembly of the crystalline carbons, which found efficiency in reinforcing the interactions between the catalyst surface and foreign pollutants. Specifically, we found that the ice crystals and NaCl promoted the evolution of MOF in a 2D fashion during the freezing casting stage, while the later further allowed the formation of a graphitic surface at high calcination temperature, by virtue of the templating effect of molten salt. Due to the highly retained co-doping amounts, N and O heteroatoms created abundant active sites for PMS activation, the 2D configuration of carbon-based nanosheets enable efficient interaction of PMS and pollutants on the surface, which further boosted the kinetics of degradation.},
  language  = {en}
}
@phdthesis{Konopka2023,
  author    = {Konopka, Torsten},
  title     = {Deutsche Blauhelme in Afrika},
  series = {Bundeswehr im Einsatz},
  volume    = {5},
  journal   = {Bundeswehr im Einsatz},
  publisher = {Vandenhoeck \& Ruprecht},
  address   = {G{\"o}ttingen},
  isbn      = {978-3-525-30239-2},
  school      = {Universit{\"a}t Potsdam},
  pages     = {780},
  year      = {2023},
  abstract  = {Warum trat die Bundesregierung ab Ende der 1980er Jahre weltweit als sicherheitspolitischer Akteur in Erscheinung? Warum engagierte sie sich in multinationalen Missionen der Vereinten Nationen etwa in Somalia, Namibia und Ruanda mit Soldaten oder Polizisten - und in anderen Missionen in Afrika im gleichen Zeitraum nicht? Gest{\"u}tzt auf ministerielle Archivquellen untersucht Torsten Konopka die Prozesse der nationalen Entscheidungsfindung, die zu einer Beteiligung oder Nichtbeteiligung an VN-Missionen in Afrika f{\"u}hrten. Das Buch leistet einen politik- sowie milit{\"a}rgeschichtlichen Beitrag zur Genese der fr{\"u}hen Auslandsverwendungen der Bundeswehr.},
  language  = {de}
}
@phdthesis{LopesFernando2023,
  author    = {Lopes Fernando, Raquel Sofia},
  title     = {The impact of aging on proteolytic systems, transcriptome and metabolome of slow and fast muscle fiber types},
  doi       = {10.25932/publishup-60579},
  school      = {Universit{\"a}t Potsdam},
  pages     = {XI, 125},
  year      = {2023},
  abstract  = {Aging is a complex process characterized by several factors, including loss of genetic and epigenetic information, accumulation of chronic oxidative stress, protein damage and aggregates and it is becoming an emergent drug target. Therefore, it is the utmost importance to study aging and agerelated diseases, to provide treatments to develop a healthy aging process. Skeletal muscle is one of the earliest tissues affected by age-related changes with progressive loss of muscle mass and function from 30 years old, effect known as sarcopenia. Several studies have shown the accumulation of protein aggregates in different animal models, as well as in humans, suggesting impaired proteostasis, a hallmark of aging, especially regarding degradation systems. Thus, different publications have explored the role of the main proteolytic systems in skeletal muscle from rodents and humans, like ubiquitin proteasomal system (UPS) and autophagy lysosomal system (ALS), however with contradictory results. Yet, most of the published studies are performed in muscles that comprise more than one fiber type, that means, muscles composed by slow and fast fibers. These fiber types, exhibit different metabolism and contraction speed; the slow fibers or type I display an oxidative metabolism, while fast fibers function towards a glycolytic metabolism ranging from fast oxidative to fast glycolytic fibers. To this extent, the aim of this thesis sought to understand on how aging impacts both fiber types not only regarding proteostasis but also at a metabolome and transcriptome network levels. Therefore, the first part of this thesis, presents the differences between slow oxidative (from Soleus muscle) and fast glycolytic fibers (Extensor digitorum longus, EDL) in terms of degradation systems and how they cope with oxidative stress during aging, while the second part explores the differences between young and old EDL muscle transcriptome and metabolome, unraveling molecular features. More specifically, the results from the present work show that slow oxidative muscle performs better at maintaining the function of UPS and ALS during aging than EDL muscle, which is clearly affected, accounting for the decline in the catalytic activity rates and accumulation of autophagy-related proteins. Strinkingly, transcriptome and metabolome analyses reveal that fast glycolytic muscle evidences significant downregulation of mitochondrial related processes and damaged mitochondria morphology during aging, despite of having a lower oxidative metabolism compared to oxidative fibers. Moreover, predictive analyses reveal a negative association between aged EDL gene signature and lifespan extending interventions such as caloric restriction (CR). Although, CR intervention does not alter the levels of mitochondrial markers in aged EDL muscle, it can reverse the higher mRNA levels of muscle damage markers. Together, the results from this thesis give new insights about how different metabolic muscle fibers cope with age-related changes and why fast glycolytic fibers are more susceptible to aging than slow oxidative fibers.},
  language  = {en}
}