@inproceedings{GundlachKoesterKrasnovaetal.2020,
  author    = {Gundlach, Jana and K{\"o}ster, Antonia and Krasnova, Hanna and Tarafdar, Monideepa},
  title     = {How messy is your news feed},
  series = {Proceedings of the 28th European Conference on Information Systems (ECIS) : ECIS 2020 Research Papers},
  booktitle = {Proceedings of the 28th European Conference on Information Systems (ECIS) : ECIS 2020 Research Papers},
  publisher = {AIS Electronic Library (AISeL)},
  address   = {[Erscheinungsort nicht ermittelbar]},
  year      = {2020},
  abstract  = {Social Networking Sites (SNSs) are pervasive in our daily lives. However, emerging reports suggest that people are increasingly dissatisfied with their experience of SNSs News Feeds. Motivated by the cognitive load theory, the paper postulates that arrangement and presentation of information are important constituents of one's Facebook News Feed experience. Integrating these factors into the novel concept of 'perceived disorder', this paper hypothesizes that the perception of disorder elicited by the Facebook News Feed plays an important role in causing discontinuance intentions. Drawing on the Stressor-Strain-Outcome Model, we suggest that perceived disorder leads to SNS discontinuance intention and is partially mediated by SNS fatigue. The paper uses the responses of 268 Facebook users to investigate these relationships and introduces perceived disorder as a novel stressor. Besides adding to the existing body of literature, these insights are of relevance to internet service providers, policy makers and SNS users.},
  language  = {en}
}
@inproceedings{KoesterBaumannKrasnovaetal.2020,
  author    = {K{\"o}ster, Antonia and Baumann, Annika and Krasnova, Hanna and Avital, Michel and Lyytinen, Kalle and Rossi, Matti},
  title     = {Panel 1: to share or not to share},
  series = {Proceedings of the 28th European Conference on Information Systems (ECIS): ECIS 2020 Panels},
  booktitle = {Proceedings of the 28th European Conference on Information Systems (ECIS): ECIS 2020 Panels},
  publisher = {AIS Electronic Library (AISeL)},
  address   = {[Erscheinungsort nicht ermittelbar]},
  year      = {2020},
  abstract  = {Data sharing requires researchers to publish their (primary) data and any supporting research materials. With increased attention on reproducibility and more transparent research requiring sharing of data, the issues surrounding data sharing are moving beyond whether data sharing is beneficial, to what kind of research data should be shared and how. However, despite its benefits, data sharing still is not common practice in Information Systems (IS) research. The panel seeks to discuss the controversies related to data sharing in research, specifically focusing on the IS discipline. It remains unclear how the positive effects of data sharing that are often framed as extending beyond the individual researcher (e.g., openness for innovation) can be utilized while reducing the downsides often associated with negative consequences for the individual researcher (e.g., losing a competitive advantage). To foster data sharing practices in IS, the panel will address this dilemma by drawing on the panelists' expertise.},
  language  = {en}
}
@inproceedings{Kosta2020,
  author    = {Kosta, Peter},
  title     = {On extraction and clitic climbing out of subject-/object-control clauses and causative clauses in romance and czech},
  series = {Current developments in Slavic linguistics - twenty years after},
  booktitle = {Current developments in Slavic linguistics - twenty years after},
  publisher = {Peter Lang},
  address   = {Berlin},
  isbn      = {978-3-631-67673-8},
  pages     = {185 -- 202},
  year      = {2020},
  language  = {en}
}
@inproceedings{DemarisGrišićHuisingaetal.2020,
  author    = {D{\´e}maris, Alise and Grišić, Ana-Marija and Huisinga, Wilhelm and Walter, Reinisch and Kloft, Charlotte},
  title     = {Evaluation of dosing strategies of anti-TNF alpha monoclonal antibodies using pharmacokinetic modelling and simulation},
  series = {Journal of Crohn's and Colitis},
  volume    = {14},
  booktitle = {Journal of Crohn's and Colitis},
  number    = {Supp. 1},
  publisher = {Oxford Univ. Press},
  address   = {Oxford},
  issn      = {1873-9946},
  doi       = {10.1093/ecco-jcc/jjz203.201},
  pages     = {S171 -- S172},
  year      = {2020},
  abstract  = {Background: Anti-TNFα monoclonal antibodies (mAbs) are a well-established treatment for patients with Crohn's disease (CD). However, subtherapeutic concentrations of mAbs have been related to a loss of response during the first year of therapy1. Therefore, an appropriate dosing strategy is crucial to prevent the underexposure of mAbs for those patients. The aim of our study was to assess the impact of different dosing strategies (fixed dose or body size descriptor adapted) on drug exposure and the target concentration attainment for two different anti-TNFα mAbs: infliximab (IFX, body weight (BW)-based dosing) and certolizumab pegol (CZP, fixed dosing). For this purpose, a comprehensive pharmacokinetic (PK) simulation study was performed. Methods: A virtual population of 1000 clinically representative CD patients was generated based on the distribution of CD patient characteristics from an in-house clinical database (n = 116). Seven dosing regimens were investigated: fixed dose and per BW, lean BW (LBW), body surface area, height, body mass index and fat-free mass. The individual body size-adjusted doses were calculated from patient generated body size descriptor values. Then, using published PK models for IFX and CZP in CD patients2,3, for each patient, 1000 concentration-time profiles were simulated to consider the typical profile of a specific patient as well as the range of possible individual profiles due to unexplained PK variability across patients. For each dosing strategy, the variability in maximum and minimum mAb concentrations (Cmax and Cmin, respectively), area under the concentration-time curve (AUC) and the per cent of patients reaching target concentration were assessed during maintenance therapy. Results: For IFX and CZP, Cmin showed the highest variability between patients (CV ≈110\% and CV ≈80\%, respectively) with a similar extent across all dosing strategies. For IFX, the per cent of patients reaching the target (Cmin = 5 µg/ml) was similar across all dosing strategies (~15\%). For CZP, the per cent of patients reaching the target average concentration of 17 µg/ml ranged substantially (52-71\%), being the highest for LBW-adjusted dosing. Conclusion: By using a PK simulation approach, different dosing regimen of IFX and CZP revealed the highest variability for Cmin, the most commonly used PK parameter guiding treatment decisions, independent upon dosing regimen. Our results demonstrate similar target attainment with fixed dosing of IFX compared with currently recommended BW-based dosing. For CZP, the current fixed dosing strategy leads to comparable percentage of patients reaching target as the best performing body size-adjusted dosing (66\% vs. 71\%, respectively).},
  language  = {en}
}
@inproceedings{RischBashfordKuligetal.2020,
  author    = {Risch, Lucie and Bashford, Greg and Kulig, Kornelia and Kaplick, Hannes and Mayer, Frank and Cassel, Michael},
  title     = {Spatial frequency analysis identifies altered local Micromorphology in adolescent athletes with Achilles tendinopathy},
  series = {Medicine and science in sports and exercise : MSSE ; official journal of the American College of Sports Medicine},
  volume    = {52},
  booktitle = {Medicine and science in sports and exercise : MSSE ; official journal of the American College of Sports Medicine},
  publisher = {Lippincott Williams \& Wilkins},
  address   = {Philadelphia},
  issn      = {0195-9131},
  doi       = {10.1249/01.mss.0000670932.99564.57},
  pages     = {82 -- 82},
  year      = {2020},
  language  = {en}
}