@phdthesis{Mueller2012, author = {M{\"u}ller, Gesine}, title = {Die Koloniale Karibik}, pages = {351}, year = {2012}, abstract = {Werden nicht in der Karibik des 19. Jahrhunderts Ph{\"a}nomene und Prozesse vorweg-genommen, die heute erst ins Bewusstsein gelangen? Der Blick auf die kaleidoskopartige Welt der Karibik {\"u}ber literarische und kulturelle Transprozesse in jener Epoche erlaubt v{\"o}llig neue Einsichten in die fr{\"u}hen Prozesse der kulturellen Globalisierung. Rassistische Diskurse, etablierte Modelle „weißer" Abolitionisten, Erinnerungspolitiken und die bisher kaum wahrgenommene Rolle der haitianischen Revolution verbinden sich zu einem Amalgam, das unser g{\"a}ngiges Konzept einer genuin westlichen Moderne in Frage stellt.}, language = {de} } @article{Apelojg2012, author = {Apelojg, Benjamin}, title = {Recruiting - Lass den Bauch sprechen}, series = {Personalwirtschaft : Magazin f{\"u}r Human Resources}, volume = {39}, journal = {Personalwirtschaft : Magazin f{\"u}r Human Resources}, number = {5}, publisher = {F.A.Z.Buisness Media}, address = {Frankfurt am Main}, issn = {0341-4698}, pages = {59 -- 62}, year = {2012}, abstract = {Personal auszuw{\"a}hlen ist eine verantwortungsvolle Aufgabe. Dabei ist es eigentlich ganz einfach: Bei der Entscheidung lohnt es sich, seinen Gef{\"u}hlen zu vertrauen.}, language = {de} } @book{ThimGronauRoechertVoigtetal.2012, author = {Thim, Christof and Gronau, Norbert and R{\"o}chert-Voigt, Tanja and Proske, Niels and Heine, Moreen}, title = {Organisation des Schutzes der kritischen Infrastruktur Wasserversorgung}, publisher = {Gito Verlag GmbH}, address = {Berlin}, isbn = {978-3-942183-78-9}, pages = {16}, year = {2012}, abstract = {Die Erf{\"u}llung sicherheitsrelevanter Aufgaben, gerade im Bereich der Wasserversorgung, erfolgt immer vor dem Hintergrund des Schutzes der Kritischen Infrastruktur selbst und eines effektiven Bev{\"o}lkerungsschutzes. Daher erfordert die Organisation des Schutzes eine {\"u}ber die betriebsbezogene Sichtweise hinausgehende {\"u}berorganisatorische Betrachtung im Gesamtkontext zunehmender Verflechtung und Abh{\"a}ngigkeiten der Organisationen. Die vorliegende Brosch{\"u}re richtet sich daher insbesondere an kleine und mittlere Betreiber Kritischer Infrastrukturen, insbesondere im Bereich der Wasserversorgung. Diese sollen in die Lage versetzt werden, eine anforderungsgerechte, skalierbare und vor allem ressourceneffiziente Schutzkonzepterstellung durchf{\"u}hren zu k{\"o}nnen.}, language = {de} } @misc{LinKhajooeiEngeletal.2012, author = {Lin, Chiao-I and Khajooei, Mina and Engel, Tilman and Nair, Alexandra and Heikkila, Mika and Kaplick, Hannes and Mayer, Frank}, title = {The effect of chronic ankle instability on muscle activations in lower extremities}, series = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Humanwissenschaftliche Reihe}, issn = {1866-8364}, doi = {10.25932/publishup-51563}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-515632}, pages = {17}, year = {2012}, abstract = {Background/Purpose Muscular reflex responses of the lower extremities to sudden gait disturbances are related to postural stability and injury risk. Chronic ankle instability (CAI) has shown to affect activities related to the distal leg muscles while walking. Its effects on proximal muscle activities of the leg, both for the injured- (IN) and uninjured-side (NON), remain unclear. Therefore, the aim was to compare the difference of the motor control strategy in ipsilateral and contralateral proximal joints while unperturbed walking and perturbed walking between individuals with CAI and matched controls. Materials and methods In a cross-sectional study, 13 participants with unilateral CAI and 13 controls (CON) walked on a split-belt treadmill with and without random left- and right-sided perturbations. EMG amplitudes of muscles at lower extremities were analyzed 200 ms after perturbations, 200 ms before, and 100 ms after (Post100) heel contact while walking. Onset latencies were analyzed at heel contacts and after perturbations. Statistical significance was set at alpha≤0.05 and 95\% confidence intervals were applied to determine group differences. Cohen's d effect sizes were calculated to evaluate the extent of differences. Results Participants with CAI showed increased EMG amplitudes for NON-rectus abdominus at Post100 and shorter latencies for IN-gluteus maximus after heel contact compared to CON (p<0.05). Overall, leg muscles (rectus femoris, biceps femoris, and gluteus medius) activated earlier and less bilaterally (d = 0.30-0.88) and trunk muscles (bilateral rectus abdominus and NON-erector spinae) activated earlier and more for the CAI group than CON group (d = 0.33-1.09). Conclusion Unilateral CAI alters the pattern of the motor control strategy around proximal joints bilaterally. Neuromuscular training for the muscles, which alters motor control strategy because of CAI, could be taken into consideration when planning rehabilitation for CAI.}, language = {en} } @misc{EbertLamprechtSteffenetal.2012, author = {Ebert, Birgitta E. and Lamprecht, Anna-Lena and Steffen, Bernhard and Blank, Lars M.}, title = {Flux-P}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {1054}, issn = {1866-8372}, doi = {10.25932/publishup-47669}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-476696}, pages = {872 -- 890}, year = {2012}, abstract = {Quantitative knowledge of intracellular fluxes in metabolic networks is invaluable for inferring metabolic system behavior and the design principles of biological systems. However, intracellular reaction rates can not often be calculated directly but have to be estimated; for instance, via 13C-based metabolic flux analysis, a model-based interpretation of stable carbon isotope patterns in intermediates of metabolism. Existing software such as FiatFlux, OpenFLUX or 13CFLUX supports experts in this complex analysis, but requires several steps that have to be carried out manually, hence restricting the use of this software for data interpretation to a rather small number of experiments. In this paper, we present Flux-P as an approach to automate and standardize 13C-based metabolic flux analysis, using the Bio-jETI workflow framework. Exemplarily based on the FiatFlux software, it demonstrates how services can be created that carry out the different analysis steps autonomously and how these can subsequently be assembled into software workflows that perform automated, high-throughput intracellular flux analysis of high quality and reproducibility. Besides significant acceleration and standardization of the data analysis, the agile workflow-based realization supports flexible changes of the analysis workflows on the user level, making it easy to perform custom analyses.}, language = {en} } @article{Saupe2012, author = {Saupe, Achim}, title = {Zur Kritik des Zeugen in der Konstitutionsphase der modernen Geschichtswissenschaft}, series = {Die Geburt des Zeitzeugen nach 1945}, journal = {Die Geburt des Zeitzeugen nach 1945}, publisher = {Wallstein}, address = {G{\"o}ttingen}, isbn = {978-3-8353-1036-0}, pages = {71 -- 92}, year = {2012}, language = {de} } @book{OPUS4-47722, title = {Die Geburt des Zeitzeugen nach 1945}, series = {Geschichte der Gegenwart / Beitr{\"a}ge zur Geschichte des 20. Jahrhunderts ; 414}, journal = {Geschichte der Gegenwart / Beitr{\"a}ge zur Geschichte des 20. Jahrhunderts ; 414}, editor = {Sabrow, Martin and Frei, Norbert}, publisher = {Wallstein}, address = {G{\"o}ttingen}, isbn = {978-3-8353-1036-0}, pages = {376}, year = {2012}, language = {de} } @article{Sabrow2012, author = {Sabrow, Martin}, title = {Der Zeitzeuge als Wanderer zwischen zwei Welten}, series = {Die Geburt des Zeitzeugen nach 1945}, journal = {Die Geburt des Zeitzeugen nach 1945}, editor = {Sabrow, Martin and Frei, Norbert}, publisher = {Wallstein}, address = {G{\"o}ttingen}, isbn = {978-3-8353-1036-0}, pages = {13 -- 32}, year = {2012}, language = {de} } @misc{CaliendoHogenacker2012, author = {Caliendo, Marco and Hogenacker, Jens}, title = {The German labor market after the Great Recession}, series = {Postprints der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe}, number = {129}, issn = {1867-5808}, doi = {10.25932/publishup-43519}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-435195}, pages = {26}, year = {2012}, abstract = {The reaction of the German labor market to the Great Recession 2008/09 was relatively mild - especially compared to other countries. The reason lies not only in the specific type of the recession - which was favorable for the German economy structure - but also in a series of labor market reforms initiated between 2002 and 2005 altering, inter alia, labor supply incentives. However, irrespective of the mild response to the Great Recession, there are a number of substantial future challenges the German labor market will soon have to face. Female labor supply still lies well below that of other countries and a massive demographic change over the next 50 years will have substantial effects on labor supply as well as the pension system. In addition, due to a skill-biased technological change over the next decades, firms will face problems of finding employees with adequate skills. The aim of this paper is threefold. First, we outline why the German labor market reacted in such a mild fashion, describe current economic trends of the labor market in light of general trends in the European Union, and reveal some of the main associated challenges. Thereafter, the paper analyzes recent reforms of the main institutional settings of the labor market which influence labor supply. Finally, based on the status quo of these institutional settings, the paper gives a brief overview of strategies to combat adequately the challenges in terms of labor supply and to ensure economic growth in the future.}, language = {en} } @misc{KrippendorffOyarzunHuisinga2012, author = {Krippendorff, Ben-Fillippo and Oyarz{\´u}n, Diego A. and Huisinga, Wilhelm}, title = {Predicting the F(ab)-mediated effect of monoclonal antibodies in vivo by combining cell-level kinetic and pharmacokinetic modelling}, series = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, journal = {Postprints der Universit{\"a}t Potsdam : Mathematisch-Naturwissenschaftliche Reihe}, number = {958}, issn = {1866-8372}, doi = {10.25932/publishup-43105}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:517-opus4-431051}, pages = {125 -- 139}, year = {2012}, abstract = {Cell-level kinetic models for therapeutically relevant processes increasingly benefit the early stages of drug development. Later stages of the drug development processes, however, rely on pharmacokinetic compartment models while cell-level dynamics are typically neglected. We here present a systematic approach to integrate cell-level kinetic models and pharmacokinetic compartment models. Incorporating target dynamics into pharmacokinetic models is especially useful for the development of therapeutic antibodies because their effect and pharmacokinetics are inherently interdependent. The approach is illustrated by analysing the F(ab)-mediated inhibitory effect of therapeutic antibodies targeting the epidermal growth factor receptor. We build a multi-level model for anti-EGFR antibodies by combining a systems biology model with in vitro determined parameters and a pharmacokinetic model based on in vivo pharmacokinetic data. Using this model, we investigated in silico the impact of biochemical properties of anti-EGFR antibodies on their F(ab)-mediated inhibitory effect. The multi-level model suggests that the F(ab)-mediated inhibitory effect saturates with increasing drug-receptor affinity, thereby limiting the impact of increasing antibody affinity on improving the effect. This indicates that observed differences in the therapeutic effects of high affinity antibodies in the market and in clinical development may result mainly from Fc-mediated indirect mechanisms such as antibody-dependent cell cytotoxicity.}, language = {en} }