@article{StadionSchuermann2020, author = {Stadion, Mandy and Sch{\"u}rmann, Annette}, title = {Intermittent fasting}, series = {Psychotherapeut}, volume = {66}, journal = {Psychotherapeut}, number = {1}, publisher = {Springer}, address = {New York}, issn = {0935-6185}, doi = {10.1007/s00278-020-00471-5}, pages = {23 -- 27}, year = {2020}, abstract = {A long-term positive energy balance leads to overweight and obesity. Adiposity is the main risk factor for cardiovascular diseases, type 2 diabetes and cancer and is often accompanied by depression. The increasing prevalence creates a major problem for the healthcare system. The conservative management of obesity strives for weight loss by reducing the daily caloric intake and increasing physical activity as well as an improvement in the quality of life supported by psychological interventions. For reducing body weight, intermittent fasting represents an alternative to continuous calorie restriction as it can be easily integrated into daily life. In this form of diet calorie intake is limited in time, i.e. on 2 days in the week or 6-10 h per day. Animal and human studies provide evidence that intermittent fasting over a longer time period is a suitable method to decrease body fat and to improve many metabolic parameters. Fasting alters metabolism and activates specific cellular pathways. These have not only cardioprotective effects but also neuroprotective and antidepressive effects. In this article the currently discussed mechanisms induced by intermittent fasting are highlighted and the essential observations from randomized controlled human trials are presented.}, language = {de} } @article{StadionSchuermann2020, author = {Stadion, Mandy and Sch{\"u}rmann, Annette}, title = {Intermittierendes Fasten}, series = {Der Diabetologe}, volume = {16}, journal = {Der Diabetologe}, number = {7}, publisher = {Springer Medizin}, address = {Berlin}, issn = {1860-9716}, doi = {10.1007/s11428-020-00666-z}, pages = {641 -- 646}, year = {2020}, abstract = {Obesity increases the risk of metabolic disorders and can lead to type 2 diabetes. Therefore, the treatment and prevention of obesity represent important medical challenges. Increased physical activity and a reduction in daily caloric intake of 25-30\% are often recommended. Another possibility is intermittent fasting, by limiting dietary caloric content over certain times, i.e. one or more days a week or for more than 14 h a day. Animal and human studies provide evidence that intermittent fasting in obesity leads to a reduction in body fat mass as well as to improvements of metabolic parameters and insulin sensitivity. These positive effects are mediated not only by the decrease in body mass, but also by the activation of metabolic pathways and cellular processes that are specific for fasting conditions. In this article, we describe the current knowledge about the mechanisms induced by intermittent fasting and present results from randomized controlled human trials.}, language = {de} }